| Disease ID | Disease name | Source of annotation with HDAC8 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS122470 | CORNELIA DE LANGE SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 7 | RAD21, TAF6, HDAC8, KMT2A, SMC1A, SMC3, NIPBL |
| PS309510 | MENTAL RETARDATION, X-LINKED SYNDROMIC | ClinVar, OMIM | link to OMIM | 27 | AP1S2, PRPS1, IGBP1, RBMX, HUWE1, RAB40AL, HSD17B10, ATP6AP2, PHF8, CLIC2, CASK, TAF1, FGD1, CUL4B, PQBP1, ZDHHC9, NONO, UPF3B, SMS, HDAC8, UBE2A, MECP2, KDM5C, ARX, SLC9A6, GRIA3, PHF6 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Viral carcinogenesis | hsa05203 | 5.08 |
| Alcoholism | hsa05034 | 5.59 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Separation of Sister Chromatids | R-HSA-2467813 | 5.55 |
| Signaling by NOTCH | R-HSA-157118 | 6.2 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Disease | R-HSA-1643685 | 3.33 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 6.18 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 5.45 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | R-HSA-2894862 | 7.15 |
| Diseases of signal transduction | R-HSA-5663202 | 4.89 |
| M Phase | R-HSA-68886 | 4.87 |
| NOTCH1 Intracellular Domain Regulates Transcription | R-HSA-2122947 | 7.43 |
| Mitotic Anaphase | R-HSA-68882 | 5.46 |
| Chromatin modifying enzymes | R-HSA-3247509 | 5.19 |
| Signaling by NOTCH1 | R-HSA-1980143 | 6.81 |
| Signaling by NOTCH1 in Cancer | R-HSA-2644603 | 7.15 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | R-HSA-2644602 | 7.15 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | R-HSA-2644606 | 7.15 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | R-HSA-2894858 | 7.15 |
| Chromatin organization | R-HSA-4839726 | 5.19 |
| HDACs deacetylate histones | R-HSA-3214815 | 7.08 |
| Mitotic Prometaphase | R-HSA-68877 | 6.08 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| deacetylase activity | GO:0019213 | 5.7 |
| histone deacetylase activity (H3-K14 specific) | GO:0031078 | 7.25 |
| cation binding | GO:0043169 | 1.4 |
| Hsp70 protein binding | GO:0030544 | 6.37 |
| heat shock protein binding | GO:0031072 | 5.24 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | GO:0016810 | 4.76 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | GO:0016811 | 5.28 |
| NAD-dependent histone deacetylase activity | GO:0017136 | 6.97 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | GO:0032041 | 7.25 |
| ion binding | GO:0043167 | 1.36 |
| NAD-dependent protein deacetylase activity | GO:0034979 | 6.85 |
| catalytic activity | GO:0003824 | 1.05 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| histone deacetylase activity | GO:0004407 | 6.0 |
| protein deacetylase activity | GO:0033558 | 5.95 |
| metal ion binding | GO:0046872 | 1.41 |
| Hsp90 protein binding | GO:0051879 | 6.37 |
| transcription factor binding | GO:0008134 | 3.46 |