Gene table of KDM5C : lysine demethylase 5C

Gene-disease associations table

Disease ID	Disease name	Source of annotation with KDM5C	OMIM link	Number of associated genes	genes
PS309510	MENTAL RETARDATION, X-LINKED SYNDROMIC	ClinVar, OMIM, HUMSAVAR	link to OMIM	27	AP1S2, PRPS1, IGBP1, RBMX, HUWE1, RAB40AL, HSD17B10, ATP6AP2, PHF8, CLIC2, CASK, TAF1, FGD1, CUL4B, PQBP1, ZDHHC9, NONO, UPF3B, SMS, HDAC8, UBE2A, MECP2, KDM5C, ARX, SLC9A6, GRIA3, PHF6

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Chromatin organization	R-HSA-4839726	5.19
HDMs demethylate histones	R-HSA-3214842	8.4
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cation binding	GO:0043169	1.4
metal ion binding	GO:0046872	1.41
transition metal ion binding	GO:0046914	2.48
dioxygenase activity	GO:0051213	5.25
catalytic activity	GO:0003824	1.05
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	GO:0016706	5.95
organic cyclic compound binding	GO:0097159	1.05
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	4.65
ion binding	GO:0043167	1.36
demethylase activity	GO:0032451	6.21
histone demethylase activity	GO:0032452	6.48
histone demethylase activity (H3-K4 specific)	GO:0032453	7.95
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
oxidoreductase activity	GO:0016491	3.12
heterocyclic compound binding	GO:1901363	1.06
zinc ion binding	GO:0008270	2.66