Disease table of SICK SINUS SYNDROME OMIM ID: PS608567

Gene-disease associations table

GeneAssociated with SICK SINUS SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SCN5AClinVar, OMIM, HUMSAVARHGNC link3p22.211272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
MYH6ClinVar, OMIM, HUMSAVARHGNC link14q11.26PS192600, 234750, PS108800, PS115200, 140500, PS608567
HCN4ClinVar, OMIM, HUMSAVARHGNC link15q24.13PS601144, PS608567, 115000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
MYH6YES3JARID2, TBX5, ELK30
HCN4YES1SP10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Adrenergic signaling in cardiomyocyteshsa042615.442SCN5A, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.028SCN5A, MYH6
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183SCN5A, HCN4, MYH6
protein binding (GO:0005515) 0.463SCN5A, HCN4, MYH6
cation channel activity (GO:0005261) 4.042SCN5A, HCN4
enzyme binding (GO:0019899) 2.272SCN5A, MYH6
small molecule binding (GO:0036094) 1.892HCN4, MYH6
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) 6.742SCN5A, HCN4
substrate-specific channel activity (GO:0022838) 3.672SCN5A, HCN4
heterocyclic compound binding (GO:1901363) 1.062HCN4, MYH6
nucleoside phosphate binding (GO:1901265) 1.962HCN4, MYH6
sodium ion transmembrane transporter activity (GO:0015081) 4.832SCN5A, HCN4
transmembrane transporter activity (GO:0022857) 2.822SCN5A, HCN4
nucleotide binding (GO:0000166) 1.962HCN4, MYH6
purine nucleotide binding (GO:0017076) 2.192HCN4, MYH6
metal ion transmembrane transporter activity (GO:0046873) 3.712SCN5A, HCN4
calmodulin binding (GO:0005516) 4.552SCN5A, MYH6
sodium channel activity (GO:0005272) 6.132SCN5A, HCN4
transporter activity (GO:0005215) 2.572SCN5A, HCN4
ion channel activity (GO:0005216) 3.712SCN5A, HCN4
cation transmembrane transporter activity (GO:0008324) 3.322SCN5A, HCN4
protein kinase binding (GO:0019901) 3.442SCN5A, MYH6
kinase binding (GO:0019900) 3.322SCN5A, MYH6
passive transmembrane transporter activity (GO:0022803) 3.62SCN5A, HCN4
substrate-specific transmembrane transporter activity (GO:0022891) 2.92SCN5A, HCN4
inorganic cation transmembrane transporter activity (GO:0022890) 3.492SCN5A, HCN4
substrate-specific transporter activity (GO:0022892) 2.722SCN5A, HCN4
cytoskeletal protein binding (GO:0008092) 3.022SCN5A, MYH6
carbohydrate derivative binding (GO:0097367) 2.032HCN4, MYH6
organic cyclic compound binding (GO:0097159) 1.052HCN4, MYH6
adenyl nucleotide binding (GO:0030554) 2.42HCN4, MYH6
ion transmembrane transporter activity (GO:0015075) 3.042SCN5A, HCN4
voltage-gated channel activity (GO:0022832) 4.492SCN5A, HCN4
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.872SCN5A, HCN4
channel activity (GO:0015267) 3.62SCN5A, HCN4
adenyl ribonucleotide binding (GO:0032559) 2.412HCN4, MYH6
gated channel activity (GO:0022836) 3.962SCN5A, HCN4
voltage-gated sodium channel activity (GO:0005248) 6.742SCN5A, HCN4
purine ribonucleotide binding (GO:0032555) 2.22HCN4, MYH6
voltage-gated ion channel activity (GO:0005244) 4.492SCN5A, HCN4
ribonucleotide binding (GO:0032553) 2.192HCN4, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
sodium channel activity (GO:0005272) -6.130.001SCN5A, HCN4
sodium ion transmembrane transporter activity (GO:0015081) -4.830.014SCN5A, HCN4
voltage-gated channel activity (GO:0022832) -4.490.027SCN5A, HCN4
voltage-gated cation channel activity (GO:0022843) NEW4.830.017SCN5A, HCN4
voltage-gated sodium channel activity (GO:0005248) -6.740.0SCN5A, HCN4
voltage-gated ion channel activity (GO:0005244) -4.490.027SCN5A, HCN4
calmodulin binding (GO:0005516) -4.550.022SCN5A, MYH6
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
multicellular organismal process (GO:0032501) 1.453SCN5A, HCN4, MYH6
muscle contraction (GO:0006936) 4.373SCN5A, HCN4, MYH6
single-multicellular organism process (GO:0044707) 1.783SCN5A, HCN4, MYH6
regulation of heart contraction (GO:0008016) 4.353SCN5A, HCN4, MYH6
single-organism cellular process (GO:0044763) 0.653SCN5A, HCN4, MYH6
regulation of cellular process (GO:0050794) 0.53SCN5A, HCN4, MYH6
regulation of heart rate (GO:0002027) 5.293SCN5A, HCN4, MYH6
muscle system process (GO:0003012) 4.183SCN5A, HCN4, MYH6
regulation of system process (GO:0044057) 3.533SCN5A, HCN4, MYH6
biological regulation (GO:0065007) 0.393SCN5A, HCN4, MYH6
regulation of multicellular organismal process (GO:0051239) 1.873SCN5A, HCN4, MYH6
regulation of blood circulation (GO:1903522) 4.053SCN5A, HCN4, MYH6
cellular process (GO:0009987) 0.263SCN5A, HCN4, MYH6
regulation of biological quality (GO:0065008) 1.683SCN5A, HCN4, MYH6
regulation of biological process (GO:0050789) 0.453SCN5A, HCN4, MYH6
single-organism process (GO:0044699) 0.483SCN5A, HCN4, MYH6
system process (GO:0003008) 2.33SCN5A, HCN4, MYH6
regulation of membrane potential (GO:0042391) 3.892SCN5A, HCN4
multicellular organismal signaling (GO:0035637) 5.362SCN5A, HCN4
regulation of transport (GO:0051049) 2.242SCN5A, HCN4
regulation of homeostatic process (GO:0032844) 3.652SCN5A, HCN4
striated muscle contraction (GO:0006941) 5.372SCN5A, MYH6
regulation of striated muscle contraction (GO:0006942) 5.382SCN5A, HCN4
signaling (GO:0023052) 3.252SCN5A, HCN4
cellular response to chemical stimulus (GO:0070887) 2.572SCN5A, HCN4
response to chemical (GO:0042221) 1.982SCN5A, HCN4
action potential (GO:0001508) 5.422SCN5A, HCN4
regulation of ion transmembrane transport (GO:0034765) 3.772SCN5A, HCN4
localization (GO:0051179) 1.42SCN5A, HCN4
anatomical structure morphogenesis (GO:0009653) 2.532SCN5A, MYH6
cardiac muscle contraction (GO:0060048) 5.882SCN5A, MYH6
regulation of transmembrane transport (GO:0034762) 3.742SCN5A, HCN4
cellular response to stimulus (GO:0051716) 1.972SCN5A, HCN4
regulation of localization (GO:0032879) 1.942SCN5A, HCN4
cardiac muscle cell action potential (GO:0086001) 6.332SCN5A, HCN4
transmembrane transport (GO:0055085) 2.722SCN5A, HCN4
sodium ion transmembrane transport (GO:0035725) 5.232SCN5A, HCN4
inorganic cation transmembrane transport (GO:0098662) 3.552SCN5A, HCN4
inorganic ion transmembrane transport (GO:0098660) 3.382SCN5A, HCN4
monovalent inorganic cation transport (GO:0015672) 3.742SCN5A, HCN4
developmental process (GO:0032502) 1.362SCN5A, MYH6
cardiac conduction (GO:0061337) 5.542SCN5A, HCN4
regulation of muscle contraction (GO:0006937) 4.752SCN5A, HCN4
cation transport (GO:0006812) 3.112SCN5A, HCN4
ion transport (GO:0006811) 2.662SCN5A, HCN4
transport (GO:0006810) 1.512SCN5A, HCN4
sodium ion transport (GO:0006814) 4.752SCN5A, HCN4
single-organism developmental process (GO:0044767) 1.492SCN5A, MYH6
ion transmembrane transport (GO:0034220) 3.082SCN5A, HCN4
metal ion transport (GO:0030001) 3.362SCN5A, HCN4
regulation of muscle system process (GO:0090257) 4.512SCN5A, HCN4
regulation of postsynaptic membrane potential (GO:0060078) 5.722SCN5A, HCN4
establishment of localization (GO:0051234) 1.482SCN5A, HCN4
regulation of cardiac muscle contraction (GO:0055117) 5.572SCN5A, HCN4
SA node cell action potential (GO:0086015) 7.942SCN5A, HCN4
single organism signaling (GO:0044700) 3.252SCN5A, HCN4
response to stimulus (GO:0050896) 1.222SCN5A, HCN4
anatomical structure development (GO:0048856) 1.582SCN5A, MYH6
regulation of membrane depolarization (GO:0003254) 6.042SCN5A, HCN4
regulation of heart rate by cardiac conduction (GO:0086091) 6.332SCN5A, HCN4
regulation of ion homeostasis (GO:2000021) 4.442SCN5A, HCN4
regulation of ion transport (GO:0043269) 3.42SCN5A, HCN4
cation transmembrane transport (GO:0098655) 3.432SCN5A, HCN4

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.035SCN5A, HCN4, MYH6
regulation of actin filament-based movement (GO:1903115) NEW6.330.004SCN5A, MYH6
muscle contraction (GO:0006936) -4.370.017SCN5A, HCN4, MYH6
regulation of system process (GO:0044057) -3.530.003SCN5A, HCN4, MYH6
regulation of heart contraction (GO:0008016) -4.350.0SCN5A, HCN4, MYH6
sodium ion transmembrane transport (GO:0035725) -5.230.019SCN5A, HCN4
striated muscle contraction (GO:0006941) -5.370.012SCN5A, MYH6
regulation of heart rate (GO:0002027) -5.290.0SCN5A, HCN4, MYH6
muscle system process (GO:0003012) -4.180.035SCN5A, HCN4, MYH6
cardiac muscle contraction (GO:0060048) -5.880.035SCN5A, MYH6
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.283SCN5A, HCN4, MYH6
cytoplasmic part (GO:0044444) 0.823SCN5A, HCN4, MYH6
cell part (GO:0044464) 0.113SCN5A, HCN4, MYH6
protein complex (GO:0043234) 1.512SCN5A, MYH6
macromolecular complex (GO:0032991) 1.352SCN5A, MYH6
integral component of membrane (GO:0016021) 1.142SCN5A, HCN4
membrane (GO:0016020) 0.682SCN5A, HCN4
organelle part (GO:0044422) 0.792SCN5A, MYH6
intracellular organelle (GO:0043229) 0.512SCN5A, MYH6
intrinsic component of membrane (GO:0031224) 1.132SCN5A, HCN4
plasma membrane (GO:0005886) 1.392SCN5A, HCN4
membrane part (GO:0044425) 0.952SCN5A, HCN4
plasma membrane part (GO:0044459) 1.952SCN5A, HCN4
organelle (GO:0043226) 0.42SCN5A, MYH6
Z disc (GO:0030018) 5.112SCN5A, MYH6
contractile fiber part (GO:0044449) 4.532SCN5A, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
intrinsic component of plasma membrane (GO:0031226) NEW2.530.005SCN5A, HCN4
intrinsic component of membrane (GO:0031224) -1.130.025SCN5A, HCN4