Gene table of HRAS : HRas proto-oncogene, GTPase

Gene-disease associations table

Disease IDDisease nameSource of annotation with HRASOMIM linkNumber of associated genesgenes
218040COSTELLO SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 2TNNT2, HRAS
109800BLADDER CANCEROMIM link to OMIM 4FGFR3, RB1, KRAS, HRAS
163200SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 3NRAS, KRAS, HRAS
185500SUPRAVALVULAR AORTIC STENOSISClinVar link to OMIM 2ELN, HRAS
162900NEVUS, EPIDERMALClinVar, OMIM link to OMIM 5FGFR3, PIK3CA, KRAS, NRAS, HRAS
137550MELANOCYTIC NEVUS SYNDROME, CONGENITALOMIM link to OMIM 2NRAS, HRAS

Download the gene annotation in CSV format

Annotation of the gene HRAS

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Bladder cancerhsa052197.38
Focal adhesionhsa045104.92
Natural killer cell mediated cytotoxicityhsa046505.53
MAPK signaling pathwayhsa040104.63
Thyroid cancerhsa052167.48
Signaling pathways regulating pluripotency of stem cellshsa045505.6
Gliomahsa052146.66
Prostate cancerhsa052156.11
Tight junctionhsa045305.53
Long-term potentiationhsa047206.64
Neurotrophin signaling pathwayhsa047225.78
Cholinergic synapsehsa047255.88
Choline metabolism in cancerhsa052316.09
FoxO signaling pathwayhsa040685.63
Serotonergic synapsehsa047265.84
Chemokine signaling pathwayhsa040625.19
Oxytocin signaling pathwayhsa049215.4
Central carbon metabolism in cancerhsa052306.7
ErbB signaling pathwayhsa040126.15
Endometrial cancerhsa052136.81
HTLV-I infectionhsa051664.59
PI3K-Akt signaling pathwayhsa041514.21
Hepatitis Chsa051605.68
Hepatitis Bhsa051615.52
B cell receptor signaling pathwayhsa046626.52
Renal cell carcinomahsa052116.6
Gap junctionhsa045406.24
VEGF signaling pathwayhsa043706.77
Proteoglycans in cancerhsa052055.02
Estrogen signaling pathwayhsa049156.11
MicroRNAs in cancerhsa052065.38
Pathways in cancerhsa052003.98
Viral carcinogenesishsa052035.08
GnRH signaling pathwayhsa049126.18
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
Melanogenesishsa049165.97
Prolactin signaling pathwayhsa049176.6
Acute myeloid leukemiahsa052216.74
Chronic myeloid leukemiahsa052206.48
Thyroid hormone signaling pathwayhsa049195.82
Long-term depressionhsa047306.74
Regulation of actin cytoskeletonhsa048104.9
T cell receptor signaling pathwayhsa046606.01
Non-small cell lung cancerhsa052236.88
Insulin signaling pathwayhsa049105.55
Alcoholismhsa050345.59
Axon guidancehsa043605.63
Fc epsilon RI signaling pathwayhsa046646.6
Endocytosishsa041444.92
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Post NMDA receptor activation eventsR-HSA-4380647.85
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.73
Constitutive Signaling by EGFRvIIIR-HSA-56378109.08
Signaling by EGFRvIII in CancerR-HSA-56378129.08
Neuronal SystemR-HSA-1123164.82
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.85
Transmission across Chemical SynapsesR-HSA-1123155.28
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by FGFR1 in diseaseR-HSA-56553027.81
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsR-HSA-4427557.7
Signaling by EGFRR-HSA-1779294.59
EPHB-mediated forward signalingR-HSA-39286627.62
DAP12 interactionsR-HSA-21721274.56
Tie2 SignalingR-HSA-2109938.81
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
Downstream signal transductionR-HSA-1867634.65
Ras activation uopn Ca2+ infux through NMDA receptorR-HSA-4429828.89
CREB phosphorylation through the activation of RasR-HSA-4427428.23
RAF activationR-HSA-56730008.34
RAF/MAP kinase cascadeR-HSA-56730015.15
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
SHC-mediated cascade:FGFR3R-HSA-56547048.81
Activation of RAS in B cellsR-HSA-116909210.66
Signaling by EGFR in CancerR-HSA-16437138.73
Signaling by FGFR in diseaseR-HSA-12260997.49
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
SHC-mediated cascade:FGFR4R-HSA-56547198.46
SHC-related events triggered by IGF1RR-HSA-24289339.81
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
EGFR Transactivation by GastrinR-HSA-21793929.81
Axon guidanceR-HSA-4224753.93
Signaling by FGFR2 in diseaseR-HSA-56552538.23
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Signaling by FGFR3 in diseaseR-HSA-56553328.52
Signaling by LeptinR-HSA-25865525.1
MAP2K and MAPK activationR-HSA-56741357.66
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
SHC-mediated cascade:FGFR1R-HSA-56546888.59
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
C-type lectin receptors (CLRs)R-HSA-56214816.06
Diseases of signal transductionR-HSA-56632024.89
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Signalling to RASR-HSA-1670445.08
SHC-mediated cascade:FGFR2R-HSA-56546998.28
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
CD209 (DC-SIGN) signalingR-HSA-56215758.59
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
p38MAPK eventsR-HSA-1710079.28
Signaling by InterleukinsR-HSA-4491474.71
Cell surface interactions at the vascular wallR-HSA-2027336.32
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
EPH-Ephrin signalingR-HSA-26823346.43
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.73
Negative regulation of MAPK pathwayR-HSA-56752217.66
Regulation of RAS by GAPsR-HSA-56584426.92
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signaling by FGFR4 in diseaseR-HSA-56552919.52
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
protein C-terminus bindingGO:00080224.5
purine ribonucleoside triphosphate bindingGO:00356392.22
bindingGO:00054880.18
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
pyrophosphatase activityGO:00164623.04
nucleotide bindingGO:00001661.96
guanyl ribonucleotide bindingGO:00325613.73
purine nucleoside bindingGO:00018832.22
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
GTP bindingGO:00055253.78
hydrolase activityGO:00167871.9
GTPase activityGO:00039244.31
nucleoside-triphosphatase activityGO:00171113.09
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesGO:00168183.03
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
hydrolase activity, acting on acid anhydridesGO:00168173.03
guanyl nucleotide bindingGO:00190013.73
protein bindingGO:00055150.46
purine ribonucleotide bindingGO:00325552.2
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19