Disease table of NEVUS, EPIDERMAL OMIM ID: 162900

Gene-disease associations table

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Gene	Associated with NEVUS, EPIDERMAL in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
FGFR3	ClinVar, OMIM, HUMSAVAR	HGNC link	4p16.3	16	603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482
HRAS	ClinVar, OMIM	HGNC link	11p15.5	6	218040, 137550, 185500, 109800, 163200, 162900
KRAS	ClinVar	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
NRAS	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.2	8	137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
PIK3CA	ClinVar, OMIM	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659

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Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

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TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	FGFR3, HRAS

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regulated gene	associated to this disease	# TFs	TFs
PIK3CA	YES	1	FOXO3
HRAS	YES	3	SP1, MAZ, TP53
NRAS	YES	1	AR
FGFR3	YES	5	SP1, SP3, SP4, STAT1, SHOX
KRAS	YES	1	MYC

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Interactions from BIOGRID - physical

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Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PIK3CA	HRAS	Yes	5	ARHGEF1, CBL, PIK3R1, IL24, DGKZ
PIK3CA	KRAS	Yes	4	THRSP, TNFSF13, IL24, PIK3R2
PIK3CA	NRAS	No	1	RPS20
PIK3CA	FGFR3	No	1	GRB2
HRAS	NRAS	No	7	RAP1GDS1, RABGGTB, MLLT4, RAF1, PIK3CG, RGL2, TMEM185A
HRAS	KRAS	No	10	RALGDS, RASSF5, RGL2, IL24, PIK3CA, BTRC, RAF1, PIK3CG, RAP1GDS1, SHOC2
NRAS	KRAS	No	6	RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1

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Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

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Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
PIK3CA	HRAS	Yes	activation, binding	101	EFNB2, KITLG, RET, TP53, AGT, GNAQ, PDGFB, TEK, PDGFRB, PTK2, FGR, CSF2RA, FGFR2, GNGT1, EFNB1, RPS6KB1, AKT1, PDGFRA, IL2, PIK3R1, CBL, MTOR, INS, IL2RB, GNB1, IGF1, FRS2, RAC1, EGFR, RPS6KA3, AKT2, JAK2, SP1, RPS6KA1, ITGA6, PRKCD, RHOA, JAK1, PRKCA, HGF, NGFR, PIK3R3, ITGB4, GRB2, IGF1R, EGF, GAB1, FGFR1, PIK3R5, MAP2K2, PELP1, GNG2, AR, EPHB2, EPHB1, INSR, CCND1, KRAS, MET, ERBB3, RAF1, ARHGEF1, KIT, GDNF, LCK, GAB2, DOK1, VEGFA, YES1, ACTN2, RPS6KA2, GNAI3, NTF3, PIK3CD, CSF2RB, PTPN11, HCK, GNA15, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, MAP2K1, SOS1, EPHA2, ERBB2, SHC1, YWHAZ, CSF2, SDC2, VAV1, SRC, FYN, GFRA1, NOTCH1, RPS6KA6, PIK3CB, IRS1, IRS2, ERBB4
PIK3CA	KRAS	Yes	activation, binding	37	BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
HRAS	FGFR3	Yes	activation, binding	18	INS, ANGPT1, KITLG, HGF, CBL, SOS2, SHC2, SHC1, SH3KBP1, SHC3, IRS1, IGF1, SOS1, EGF, PDGFB, VEGFA, GRB2, CSF1
HRAS	KRAS	Yes	binding	111	RASA1, AKT1, RASSF4, TP53, MAP3K2, PIK3CA, EGFR, GAST, NCAM1, YWHAB, SPTAN1, PPARD, PTK2, MAPK14, RET, CALM1, SLC3A2, MAPK13, RPS6KB1, JUN, ETS2, ABL1, SPTBN5, CCR5, TNS4, MAPK3, BTRC, MTOR, FRS2, MAZ, MAP3K3, ARAF, KSR2, IL8, LGALS3, JUND, RASGRP3, SPTBN1, DDX43, TEK, KSR1, CNKSR3, SHC3, RGL4, NPM1, GRB2, RASGRF2, MAP3K19, RALGDS, SPTA1, RASA2, CDX1, SPRY2, UBC, MLLT4, MAP2K2, BMP4, NT5E, SPTBN4, HBEGF, FYN, RGL1, RASSF2, MAPK11, CCND1, SHC2, ERBB3, ETS1, RAF1, SHOC2, KIT, LGALS1, PTPRA, VEGFA, MAPK12, YES1, MGMT, SPTB, MEN1, RASGRP1, RASA3, PIK3CD, MDM4, PTPN11, PIK3CG, IGF2BP1, ANGPT1, ITSN1, MAP2K1, SOS1, EPHA2, ERBB2, MECOM, SHC1, MAPK7, NCL, AKT2, CDX2, SPTBN2, EGF, RASSF7, SRC, BCL2L11, NOTCH1, BCL2, MAPK1, PIK3CB, IRS1, IRS2, BRAF, ERBB4
PIK3CA	FGFR3	No	-	25	FIGF, IRS1, PGF, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, SOS1, CBLB, SHC1, PDGFA, HGF, HRAS, GRB2, VEGFA, VEGFC, STAT3, CBL, CBLC, INS, IGF1, EGF, EFNA1
FGFR3	KRAS	No	-	12	HSP90AA1, ANGPT1, HRAS, PRMT5, IRS1, SHC3, SHC2, SOS1, EGF, SHC1, VEGFA, GRB2

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Interactions from CORUM

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Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
HRAS	NRAS	Yes	RAF1-RAS complex, EGF induced	2	KRAS, RAF1
HRAS	KRAS	Yes	RAF1-RAS complex, EGF induced	2	NRAS, RAF1
NRAS	KRAS	Yes	RAF1-RAS complex, EGF induced	2	HRAS, RAF1

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Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

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Gene1	Gene2	Direct interaction	More information
HRAS	KRAS	No
HRAS	NRAS	maybe, indirect	They are member of the same protein family.
KRAS	NRAS	maybe, indirect	They are members of the same protein family.

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KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

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KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Thyroid cancer	hsa05216	7.48	3	HRAS, KRAS, NRAS
Aldosterone-regulated sodium reabsorption	hsa04960	7.41	2	KRAS, PIK3CA
Bladder cancer	hsa05219	7.38	4	FGFR3, HRAS, KRAS, NRAS
Non-small cell lung cancer	hsa05223	6.88	4	HRAS, KRAS, NRAS, PIK3CA
Endometrial cancer	hsa05213	6.81	4	HRAS, KRAS, NRAS, PIK3CA
VEGF signaling pathway	hsa04370	6.77	4	HRAS, KRAS, NRAS, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	4	HRAS, KRAS, NRAS, PIK3CA
Long-term depression	hsa04730	6.74	3	HRAS, KRAS, NRAS
Central carbon metabolism in cancer	hsa05230	6.7	5	FGFR3, HRAS, KRAS, NRAS, PIK3CA
Glioma	hsa05214	6.66	4	HRAS, KRAS, NRAS, PIK3CA

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
Thyroid cancer (hsa05216)	-	7.48	0.0	HRAS, KRAS, NRAS
Aldosterone-regulated sodium reabsorption (hsa04960)	-	7.41	0.037	KRAS, PIK3CA
Bladder cancer (hsa05219)	-	7.38	0.0	FGFR3, HRAS, KRAS, NRAS
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	HRAS, KRAS, NRAS, PIK3CA
Endometrial cancer (hsa05213)	-	6.81	0.0	HRAS, KRAS, NRAS, PIK3CA
VEGF signaling pathway (hsa04370)	-	6.77	0.0	HRAS, KRAS, NRAS, PIK3CA
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	HRAS, KRAS, NRAS, PIK3CA
Long-term depression (hsa04730)	-	6.74	0.001	HRAS, KRAS, NRAS
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.0	FGFR3, HRAS, KRAS, NRAS, PIK3CA
Glioma (hsa05214)	-	6.66	0.0	HRAS, KRAS, NRAS, PIK3CA

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REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

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REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Activation of RAS in B cells	R-HSA-1169092	10.66	3	HRAS, KRAS, NRAS
EGFR Transactivation by Gastrin	R-HSA-2179392	9.81	3	HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R	R-HSA-2428933	9.81	3	HRAS, KRAS, NRAS
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	4	HRAS, KRAS, NRAS, PIK3CA
p38MAPK events	R-HSA-171007	9.28	3	HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	4	HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	4	HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.81	4	FGFR3, HRAS, KRAS, NRAS
Tie2 Signaling	R-HSA-210993	8.81	4	HRAS, KRAS, NRAS, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	4	HRAS, KRAS, NRAS, PIK3CA

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NET-GE enrichment

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Term	New enriched term	IC	Genes
Activation of RAS in B cells (R-HSA-1169092)	-	10.66	HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933)	-	9.81	HRAS, KRAS, NRAS
EGFR Transactivation by Gastrin (R-HSA-2179392)	-	9.81	HRAS, KRAS, NRAS
Signaling by FGFR4 in disease (R-HSA-5655291)	-	9.52	HRAS, KRAS, NRAS, PIK3CA
p38MAPK events (R-HSA-171007)	-	9.28	HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810)	-	9.08	HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFRvIII in Cancer (R-HSA-5637812)	-	9.08	HRAS, KRAS, NRAS, PIK3CA
Tie2 Signaling (R-HSA-210993)	-	8.81	HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR3 (R-HSA-5654704)	-	8.81	FGFR3, HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815)	-	8.73	HRAS, KRAS, NRAS, PIK3CA

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GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
1-phosphatidylinositol-3-kinase activity (GO:0016303)	5.98	2	FGFR3, PIK3CA
phosphatidylinositol kinase activity (GO:0052742)	5.81	2	FGFR3, PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	2	FGFR3, PIK3CA
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	2	FGFR3, PIK3CA
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	FGFR3, PIK3CA
GTPase activity (GO:0003924)	4.31	2	HRAS, KRAS
GTP binding (GO:0005525)	3.78	3	HRAS, KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561)	3.73	3	HRAS, KRAS, NRAS
guanyl nucleotide binding (GO:0019001)	3.73	3	HRAS, KRAS, NRAS
protein kinase activity (GO:0004672)	3.27	2	FGFR3, PIK3CA

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
NAD+ kinase activity (GO:0003951)	NEW	9.05	0.012	HRAS, KRAS
diacylglycerol kinase activity (GO:0004143)	NEW	7.34	0.01	HRAS, KRAS
NF-kappaB binding (GO:0051059)	NEW	6.34	0.014	HRAS, KRAS
phosphatidylserine binding (GO:0001786)	NEW	6.24	0.023	HRAS, KRAS
calcium-dependent protein binding (GO:0048306)	NEW	5.68	0.001	HRAS, KRAS, PIK3CA
growth factor receptor binding (GO:0070851)	NEW	4.87	0.01	FGFR3, HRAS, PIK3CA
receptor signaling protein activity (GO:0005057)	NEW	4.76	0.015	FGFR3, HRAS, PIK3CA
protein binding, bridging (GO:0030674)	NEW	4.68	0.027	HRAS, KRAS, NRAS
phosphatase binding (GO:0019902)	NEW	4.63	0.022	HRAS, KRAS, PIK3CA
binding, bridging (GO:0060090)	NEW	4.57	0.0	HRAS, KRAS, NRAS, PIK3CA

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GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
regulation of long-term neuronal synaptic plasticity (GO:0048169)	6.55	2	HRAS, KRAS
positive regulation of Ras protein signal transduction (GO:0046579)	6.2	2	HRAS, KRAS
ERBB2 signaling pathway (GO:0038128)	6.09	4	HRAS, KRAS, NRAS, PIK3CA
positive regulation of small GTPase mediated signal transduction (GO:0051057)	6.04	2	HRAS, KRAS
social behavior (GO:0035176)	5.9	2	HRAS, KRAS
intraspecies interaction between organisms (GO:0051703)	5.9	2	HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168)	5.84	2	HRAS, KRAS
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	5.84	2	FGFR3, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	4	HRAS, KRAS, NRAS, PIK3CA
multi-organism behavior (GO:0051705)	5.6	2	HRAS, KRAS

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
guanosine-containing compound catabolic process (GO:1901069)	NEW	8.63	0.011	HRAS, KRAS, NRAS, PIK3CA
positive regulation of Rac protein signal transduction (GO:0035022)	NEW	8.63	0.0	HRAS, KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020)	NEW	7.24	0.0	HRAS, KRAS, NRAS
neurotrophin TRK receptor signaling pathway (GO:0048011)	NEW	6.96	0.0	FGFR3, HRAS, KRAS, NRAS, PIK3CA
epithelial tube branching involved in lung morphogenesis (GO:0060441)	NEW	6.9	0.0	HRAS, KRAS, NRAS
GTP metabolic process (GO:0046039)	NEW	6.59	0.014	HRAS, KRAS, NRAS, PIK3CA
neurotrophin signaling pathway (GO:0038179)	NEW	6.55	0.0	FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of long-term neuronal synaptic plasticity (GO:0048169)	-	6.55	0.0	HRAS, KRAS, NRAS
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.0	FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of synaptic transmission, GABAergic (GO:0032228)	NEW	6.36	0.0	HRAS, KRAS, NRAS

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GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
cell-substrate adherens junction (GO:0005924)	3.83	2	FGFR3, KRAS
focal adhesion (GO:0005925)	3.83	2	FGFR3, KRAS
cell-substrate junction (GO:0030055)	3.82	2	FGFR3, KRAS
adherens junction (GO:0005912)	3.66	2	FGFR3, KRAS
anchoring junction (GO:0070161)	3.61	2	FGFR3, KRAS
Golgi membrane (GO:0000139)	3.28	2	HRAS, NRAS
Golgi apparatus part (GO:0044431)	3.0	2	HRAS, NRAS
cell junction (GO:0030054)	2.75	2	FGFR3, KRAS
Golgi apparatus (GO:0005794)	2.7	3	FGFR3, HRAS, NRAS
bounding membrane of organelle (GO:0098588)	2.39	2	HRAS, NRAS

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
cytosolic part (GO:0044445)	NEW	4.34	0.009	HRAS, KRAS, PIK3CA
endosome membrane (GO:0010008)	NEW	3.83	0.009	HRAS, KRAS, NRAS, PIK3CA
extracellular matrix (GO:0031012)	NEW	3.81	0.004	FGFR3, HRAS, KRAS, PIK3CA
endosomal part (GO:0044440)	NEW	3.73	0.011	HRAS, KRAS, NRAS, PIK3CA
Golgi membrane (GO:0000139)	-	3.28	0.032	HRAS, KRAS, NRAS, PIK3CA
integral component of plasma membrane (GO:0005887)	NEW	2.57	0.023	FGFR3, HRAS, KRAS, NRAS, PIK3CA
plasma membrane (GO:0005886)	-	1.39	0.021	FGFR3, HRAS, KRAS, NRAS, PIK3CA

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