Disease table of NEVUS, EPIDERMAL OMIM ID: 162900

Gene-disease associations table

GeneAssociated with NEVUS, EPIDERMAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PIK3CAClinVar, OMIMHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
HRASClinVar, OMIMHGNC link11p15.56218040, 137550, 185500, 109800, 163200, 162900
NRASClinVar, OMIM, HUMSAVARHGNC link1p13.28137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
FGFR3ClinVar, OMIM, HUMSAVARHGNC link4p16.316603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482
KRASClinVarHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12FGFR3, HRAS
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PIK3CAYES1FOXO30
HRASYES3SP1, MAZ, TP530
NRASYES1AR0
FGFR3YES5SP1, SP3, SP4, STAT1, SHOX0
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PIK3CAHRASYes5ARHGEF1, CBL, PIK3R1, IL24, DGKZ
PIK3CANRASNo1RPS20
PIK3CAFGFR3No1GRB2
PIK3CAKRASYes4THRSP, TNFSF13, IL24, PIK3R2
HRASNRASNo7RAP1GDS1, RABGGTB, MLLT4, RAF1, PIK3CG, RGL2, TMEM185A
HRASKRASNo10RALGDS, RASSF5, RGL2, IL24, PIK3CA, BTRC, RAF1, PIK3CG, RAP1GDS1, SHOC2
NRASKRASNo6RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PIK3CAHRASYesactivation, binding101EFNB2, KITLG, RET, TP53, AGT, GNAQ, PDGFB, TEK, PDGFRB, PTK2, FGR, CSF2RA, FGFR2, GNGT1, EFNB1, RPS6KB1, AKT1, PDGFRA, IL2, PIK3R1, CBL, MTOR, INS, IL2RB, GNB1, IGF1, FRS2, RAC1, EGFR, RPS6KA3, AKT2, JAK2, SP1, RPS6KA1, ITGA6, PRKCD, RHOA, JAK1, PRKCA, HGF, NGFR, PIK3R3, ITGB4, GRB2, IGF1R, EGF, GAB1, FGFR1, PIK3R5, MAP2K2, PELP1, GNG2, AR, EPHB2, EPHB1, INSR, CCND1, KRAS, MET, ERBB3, RAF1, ARHGEF1, KIT, GDNF, LCK, GAB2, DOK1, VEGFA, YES1, ACTN2, RPS6KA2, GNAI3, NTF3, PIK3CD, CSF2RB, PTPN11, HCK, GNA15, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, MAP2K1, SOS1, EPHA2, ERBB2, SHC1, YWHAZ, CSF2, SDC2, VAV1, SRC, FYN, GFRA1, NOTCH1, RPS6KA6, PIK3CB, IRS1, IRS2, ERBB4
PIK3CAFGFR3No-25FIGF, IRS1, PGF, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, SOS1, CBLB, SHC1, PDGFA, HGF, HRAS, GRB2, VEGFA, VEGFC, STAT3, CBL, CBLC, INS, IGF1, EGF, EFNA1
PIK3CAKRASYesactivation, binding37BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
HRASFGFR3Yesactivation, binding18INS, ANGPT1, KITLG, HGF, CBL, SOS2, SHC2, SHC1, SH3KBP1, SHC3, IRS1, IGF1, SOS1, EGF, PDGFB, VEGFA, GRB2, CSF1
HRASKRASYesbinding111RASA1, AKT1, RASSF4, TP53, MAP3K2, PIK3CA, EGFR, GAST, NCAM1, YWHAB, SPTAN1, PPARD, PTK2, MAPK14, RET, CALM1, SLC3A2, MAPK13, RPS6KB1, JUN, ETS2, ABL1, SPTBN5, CCR5, TNS4, MAPK3, BTRC, MTOR, FRS2, MAZ, MAP3K3, ARAF, KSR2, IL8, LGALS3, JUND, RASGRP3, SPTBN1, DDX43, TEK, KSR1, CNKSR3, SHC3, RGL4, NPM1, GRB2, RASGRF2, MAP3K19, RALGDS, SPTA1, RASA2, CDX1, SPRY2, UBC, MLLT4, MAP2K2, BMP4, NT5E, SPTBN4, HBEGF, FYN, RGL1, RASSF2, MAPK11, CCND1, SHC2, ERBB3, ETS1, RAF1, SHOC2, KIT, LGALS1, PTPRA, VEGFA, MAPK12, YES1, MGMT, SPTB, MEN1, RASGRP1, RASA3, PIK3CD, MDM4, PTPN11, PIK3CG, IGF2BP1, ANGPT1, ITSN1, MAP2K1, SOS1, EPHA2, ERBB2, MECOM, SHC1, MAPK7, NCL, AKT2, CDX2, SPTBN2, EGF, RASSF7, SRC, BCL2L11, NOTCH1, BCL2, MAPK1, PIK3CB, IRS1, IRS2, BRAF, ERBB4
FGFR3KRASNo-12HSP90AA1, ANGPT1, HRAS, PRMT5, IRS1, SHC3, SHC2, SOS1, EGF, SHC1, VEGFA, GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
HRASNRASYesRAF1-RAS complex, EGF induced2KRAS, RAF1
HRASKRASYesRAF1-RAS complex, EGF induced2NRAS, RAF1
NRASKRASYesRAF1-RAS complex, EGF induced2HRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
HRASKRASNo
HRASNRASmaybe, indirectThey are member of the same protein family.
KRASNRASmaybe, indirectThey are members of the same protein family.
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.65FGFR3, HRAS, KRAS, NRAS, PIK3CA
MicroRNAs in cancerhsa052065.385FGFR3, HRAS, KRAS, NRAS, PIK3CA
Pathways in cancerhsa052003.985FGFR3, HRAS, KRAS, NRAS, PIK3CA
Rap1 signaling pathwayhsa040154.975FGFR3, HRAS, KRAS, NRAS, PIK3CA
Ras signaling pathwayhsa040144.95FGFR3, HRAS, KRAS, NRAS, PIK3CA
Central carbon metabolism in cancerhsa052306.75FGFR3, HRAS, KRAS, NRAS, PIK3CA
Regulation of actin cytoskeletonhsa048104.95FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI3K-Akt signaling pathwayhsa041514.215FGFR3, HRAS, KRAS, NRAS, PIK3CA
Melanomahsa052186.564HRAS, KRAS, NRAS, PIK3CA
Bladder cancerhsa052197.384FGFR3, HRAS, KRAS, NRAS
Natural killer cell mediated cytotoxicityhsa046505.534HRAS, KRAS, NRAS, PIK3CA
Renal cell carcinomahsa052116.64HRAS, KRAS, NRAS, PIK3CA
Gliomahsa052146.664HRAS, KRAS, NRAS, PIK3CA
Prostate cancerhsa052156.114HRAS, KRAS, NRAS, PIK3CA
Neurotrophin signaling pathwayhsa047225.784HRAS, KRAS, NRAS, PIK3CA
Cholinergic synapsehsa047255.884HRAS, KRAS, NRAS, PIK3CA
Choline metabolism in cancerhsa052316.094HRAS, KRAS, NRAS, PIK3CA
FoxO signaling pathwayhsa040685.634HRAS, KRAS, NRAS, PIK3CA
Chemokine signaling pathwayhsa040625.194HRAS, KRAS, NRAS, PIK3CA
Oxytocin signaling pathwayhsa049215.44HRAS, KRAS, NRAS, PIK3CA
Endometrial cancerhsa052136.814HRAS, KRAS, NRAS, PIK3CA
HTLV-I infectionhsa051664.594HRAS, KRAS, NRAS, PIK3CA
Hepatitis Chsa051605.684HRAS, KRAS, NRAS, PIK3CA
Hepatitis Bhsa051615.524HRAS, KRAS, NRAS, PIK3CA
VEGF signaling pathwayhsa043706.774HRAS, KRAS, NRAS, PIK3CA
Proteoglycans in cancerhsa052055.024HRAS, KRAS, NRAS, PIK3CA
Estrogen signaling pathwayhsa049156.114HRAS, KRAS, NRAS, PIK3CA
Viral carcinogenesishsa052035.084HRAS, KRAS, NRAS, PIK3CA
T cell receptor signaling pathwayhsa046606.014HRAS, KRAS, NRAS, PIK3CA
B cell receptor signaling pathwayhsa046626.524HRAS, KRAS, NRAS, PIK3CA
Non-small cell lung cancerhsa052236.884HRAS, KRAS, NRAS, PIK3CA
ErbB signaling pathwayhsa040126.154HRAS, KRAS, NRAS, PIK3CA
Acute myeloid leukemiahsa052216.744HRAS, KRAS, NRAS, PIK3CA
Chronic myeloid leukemiahsa052206.484HRAS, KRAS, NRAS, PIK3CA
Thyroid hormone signaling pathwayhsa049195.824HRAS, KRAS, NRAS, PIK3CA
MAPK signaling pathwayhsa040104.634FGFR3, HRAS, KRAS, NRAS
Insulin signaling pathwayhsa049105.554HRAS, KRAS, NRAS, PIK3CA
Fc epsilon RI signaling pathwayhsa046646.64HRAS, KRAS, NRAS, PIK3CA
Prolactin signaling pathwayhsa049176.64HRAS, KRAS, NRAS, PIK3CA
GnRH signaling pathwayhsa049126.183HRAS, KRAS, NRAS
Gap junctionhsa045406.243HRAS, KRAS, NRAS
Thyroid cancerhsa052167.483HRAS, KRAS, NRAS
Tight junctionhsa045305.533HRAS, KRAS, NRAS
Long-term potentiationhsa047206.643HRAS, KRAS, NRAS
Melanogenesishsa049165.973HRAS, KRAS, NRAS
Alcoholismhsa050345.593HRAS, KRAS, NRAS
Serotonergic synapsehsa047265.843HRAS, KRAS, NRAS
Axon guidancehsa043605.633HRAS, KRAS, NRAS
Long-term depressionhsa047306.743HRAS, KRAS, NRAS
Aldosterone-regulated sodium reabsorptionhsa049607.412KRAS, PIK3CA
Progesterone-mediated oocyte maturationhsa049146.182KRAS, PIK3CA
Pancreatic cancerhsa052126.562KRAS, PIK3CA
Colorectal cancerhsa052106.522KRAS, PIK3CA
Endocytosishsa041444.922FGFR3, HRAS
Focal adhesionhsa045104.922HRAS, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Bladder cancer (hsa05219) -7.380.0FGFR3, HRAS, KRAS, NRAS
Acute myeloid leukemia (hsa05221) -6.740.0HRAS, KRAS, NRAS, PIK3CA
Pancreatic cancer (hsa05212) -6.560.003HRAS, KRAS, PIK3CA
Endometrial cancer (hsa05213) -6.810.0HRAS, KRAS, NRAS, PIK3CA
Colorectal cancer (hsa05210) -6.520.003HRAS, KRAS, PIK3CA
Estrogen signaling pathway (hsa04915) -6.110.0HRAS, KRAS, NRAS, PIK3CA
Thyroid cancer (hsa05216) -7.480.0HRAS, KRAS, NRAS
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Glioma (hsa05214) -6.660.0HRAS, KRAS, NRAS, PIK3CA
Prostate cancer (hsa05215) -6.110.0HRAS, KRAS, NRAS, PIK3CA
Tight junction (hsa04530) -5.530.049HRAS, KRAS, NRAS
Nervous systemNEW3.770.006FGFR3, HRAS, KRAS, NRAS, PIK3CA
Neurotrophin signaling pathway (hsa04722) -5.780.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Cholinergic synapse (hsa04725) -5.880.0HRAS, KRAS, NRAS, PIK3CA
Endocytosis (hsa04144) -4.920.005FGFR3, HRAS, KRAS, PIK3CA
FoxO signaling pathway (hsa04068) -5.630.0HRAS, KRAS, NRAS, PIK3CA
Serotonergic synapse (hsa04726) -5.840.029HRAS, KRAS, NRAS
Chemokine signaling pathway (hsa04062) -5.190.0HRAS, KRAS, NRAS, PIK3CA
Oxytocin signaling pathway (hsa04921) -5.40.0HRAS, KRAS, NRAS, PIK3CA
DevelopmentNEW4.580.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Cellular communityNEW3.570.014FGFR3, HRAS, KRAS, NRAS, PIK3CA
Aldosterone-regulated sodium reabsorption (hsa04960) -7.410.037KRAS, PIK3CA
Substance dependenceNEW4.770.011HRAS, KRAS, NRAS, PIK3CA
Central carbon metabolism in cancer (hsa05230) -6.70.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.0HRAS, KRAS, NRAS, PIK3CA
Fc gamma R-mediated phagocytosis (hsa04666) NEW6.210.008HRAS, KRAS, PIK3CA
HTLV-I infection (hsa05166) -4.590.002HRAS, KRAS, NRAS, PIK3CA
PI3K-Akt signaling pathway (hsa04151) -4.210.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Hepatitis C (hsa05160) -5.680.001HRAS, KRAS, NRAS, PIK3CA
Hepatitis B (hsa05161) -5.520.001HRAS, KRAS, NRAS, PIK3CA
B cell receptor signaling pathway (hsa04662) -6.520.0HRAS, KRAS, NRAS, PIK3CA
Cancers: OverviewNEW2.720.009FGFR3, HRAS, KRAS, NRAS, PIK3CA
Renal cell carcinoma (hsa05211) -6.60.0HRAS, KRAS, NRAS, PIK3CA
Gap junction (hsa04540) -6.240.002HRAS, KRAS, NRAS
VEGF signaling pathway (hsa04370) -6.770.0HRAS, KRAS, NRAS, PIK3CA
Proteoglycans in cancer (hsa05205) -5.020.004HRAS, KRAS, NRAS, PIK3CA
MicroRNAs in cancer (hsa05206) -5.380.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Pathways in cancer (hsa05200) -3.980.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
Viral carcinogenesis (hsa05203) -5.080.005HRAS, KRAS, NRAS, PIK3CA
GnRH signaling pathway (hsa04912) -6.180.003HRAS, KRAS, NRAS
Rap1 signaling pathway (hsa04015) -4.970.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Ras signaling pathway (hsa04014) -4.90.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Melanogenesis (hsa04916) -5.970.017HRAS, KRAS, NRAS
ErbB signaling pathway (hsa04012) -6.150.0HRAS, KRAS, NRAS, PIK3CA
Progesterone-mediated oocyte maturation (hsa04914) -6.180.01HRAS, KRAS, PIK3CA
Chronic myeloid leukemia (hsa05220) -6.480.0HRAS, KRAS, NRAS, PIK3CA
Thyroid hormone signaling pathway (hsa04919) -5.820.0HRAS, KRAS, NRAS, PIK3CA
Cell motilityNEW4.90.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Prolactin signaling pathway (hsa04917) -6.60.0HRAS, KRAS, NRAS, PIK3CA
Long-term depression (hsa04730) -6.740.001HRAS, KRAS, NRAS
Regulation of actin cytoskeleton (hsa04810) -4.90.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
T cell receptor signaling pathway (hsa04660) -6.010.0HRAS, KRAS, NRAS, PIK3CA
Long-term potentiation (hsa04720) -6.640.001HRAS, KRAS, NRAS
Non-small cell lung cancer (hsa05223) -6.880.0HRAS, KRAS, NRAS, PIK3CA
MAPK signaling pathway (hsa04010) -4.630.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Insulin signaling pathway (hsa04910) -5.550.0HRAS, KRAS, NRAS, PIK3CA
Cancers: Specific typesNEW4.10.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Alcoholism (hsa05034) -5.590.001HRAS, KRAS, NRAS, PIK3CA
Axon guidance (hsa04360) -5.630.009HRAS, KRAS, NRAS
Circulatory systemNEW4.630.013HRAS, KRAS, NRAS, PIK3CA
Fc epsilon RI signaling pathway (hsa04664) -6.60.0HRAS, KRAS, NRAS, PIK3CA
Choline metabolism in cancer (hsa05231) -6.090.0HRAS, KRAS, NRAS, PIK3CA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.855FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR3 in diseaseR-HSA-56553328.525FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by InterleukinsR-HSA-4491474.715FGFR3, HRAS, KRAS, NRAS, PIK3CA
Immune SystemR-HSA-1682562.375FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.625FGFR3, HRAS, KRAS, NRAS, PIK3CA
Cytokine Signaling in Immune systemR-HSA-12802153.745FGFR3, HRAS, KRAS, NRAS, PIK3CA
IGF1R signaling cascadeR-HSA-24289244.855FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signal transductionR-HSA-1867634.655FGFR3, HRAS, KRAS, NRAS, PIK3CA
IRS-related events triggered by IGF1RR-HSA-24289284.855FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by ERBB4R-HSA-12363944.75FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by Insulin receptorR-HSA-747524.735FGFR3, HRAS, KRAS, NRAS, PIK3CA
Adaptive Immune SystemR-HSA-12802183.195FGFR3, HRAS, KRAS, NRAS, PIK3CA
DiseaseR-HSA-16436853.335FGFR3, HRAS, KRAS, NRAS, PIK3CA
Insulin receptor signalling cascadeR-HSA-747514.855FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR1R-HSA-56546874.715FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signalling by NGFR-HSA-1665204.235FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by VEGFR-HSA-1941384.665FGFR3, HRAS, KRAS, NRAS, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.265FGFR3, HRAS, KRAS, NRAS, PIK3CA
IRS-mediated signallingR-HSA-1123994.875FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.595FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR3R-HSA-56547084.715FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR4R-HSA-56547434.695FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR in diseaseR-HSA-12260997.495FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR3R-HSA-56547414.695FGFR3, HRAS, KRAS, NRAS, PIK3CA
VEGFA-VEGFR2 PathwayR-HSA-44200974.75FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFRR-HSA-1902364.675FGFR3, HRAS, KRAS, NRAS, PIK3CA
Diseases of signal transductionR-HSA-56632024.895FGFR3, HRAS, KRAS, NRAS, PIK3CA
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.035FGFR3, HRAS, KRAS, NRAS, PIK3CA
Interleukin-2 signalingR-HSA-4519275.055FGFR3, HRAS, KRAS, NRAS, PIK3CA
Interleukin receptor SHC signalingR-HSA-9125265.095FGFR3, HRAS, KRAS, NRAS, PIK3CA
Innate Immune SystemR-HSA-1682493.175FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by SCF-KITR-HSA-14335574.735FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by PDGFR-HSA-1867974.535FGFR3, HRAS, KRAS, NRAS, PIK3CA
DAP12 signalingR-HSA-24244914.645FGFR3, HRAS, KRAS, NRAS, PIK3CA
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.995FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR2R-HSA-56546964.715FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFRR-HSA-1779294.595FGFR3, HRAS, KRAS, NRAS, PIK3CA
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.515FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by GPCRR-HSA-3727902.685FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR2R-HSA-56547384.685FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR1R-HSA-56547364.695FGFR3, HRAS, KRAS, NRAS, PIK3CA
DAP12 interactionsR-HSA-21721274.565FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR4R-HSA-56547164.715FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by ERBB2R-HSA-12279864.665FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signal TransductionR-HSA-1625821.785FGFR3, HRAS, KRAS, NRAS, PIK3CA
GRB2 events in ERBB2 signalingR-HSA-19636405.154FGFR3, HRAS, KRAS, NRAS
Frs2-mediated activationR-HSA-1709685.124FGFR3, HRAS, KRAS, NRAS
Cell surface interactions at the vascular wallR-HSA-2027336.324HRAS, KRAS, NRAS, PIK3CA
MAPK1/MAPK3 signalingR-HSA-56849965.114FGFR3, HRAS, KRAS, NRAS
Developmental BiologyR-HSA-12667383.484FGFR3, HRAS, KRAS, NRAS
RAF/MAP kinase cascadeR-HSA-56730015.154FGFR3, HRAS, KRAS, NRAS
MAPK family signaling cascadesR-HSA-56830574.894FGFR3, HRAS, KRAS, NRAS
Signalling to p38 via RIT and RINR-HSA-1877065.124FGFR3, HRAS, KRAS, NRAS
FCERI mediated MAPK activationR-HSA-28717964.324FGFR3, HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.734HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR2 signalingR-HSA-56547005.144FGFR3, HRAS, KRAS, NRAS
SOS-mediated signallingR-HSA-1124125.154FGFR3, HRAS, KRAS, NRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.144FGFR3, HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.084HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR3R-HSA-56547048.814FGFR3, HRAS, KRAS, NRAS
Signaling by EGFRvIII in CancerR-HSA-56378129.084HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFR in CancerR-HSA-16437138.734HRAS, KRAS, NRAS, PIK3CA
Signaling by LeptinR-HSA-25865525.14FGFR3, HRAS, KRAS, NRAS
Signaling by FGFR1 in diseaseR-HSA-56553027.814HRAS, KRAS, NRAS, PIK3CA
NCAM signaling for neurite out-growthR-HSA-3751654.94FGFR3, HRAS, KRAS, NRAS
Signalling to RASR-HSA-1670445.084FGFR3, HRAS, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.734HRAS, KRAS, NRAS, PIK3CA
SHC1 events in EGFR signalingR-HSA-1803365.154FGFR3, HRAS, KRAS, NRAS
FRS-mediated FGFR1 signalingR-HSA-56546935.144FGFR3, HRAS, KRAS, NRAS
Prolonged ERK activation eventsR-HSA-1698935.114FGFR3, HRAS, KRAS, NRAS
Signalling to ERKsR-HSA-1876875.044FGFR3, HRAS, KRAS, NRAS
GRB2 events in EGFR signalingR-HSA-1798125.154FGFR3, HRAS, KRAS, NRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.154FGFR3, HRAS, KRAS, NRAS
ARMS-mediated activationR-HSA-1709845.124FGFR3, HRAS, KRAS, NRAS
Signaling by FGFR4 in diseaseR-HSA-56552919.524HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR4 signalingR-HSA-56547125.144FGFR3, HRAS, KRAS, NRAS
Tie2 SignalingR-HSA-2109938.814HRAS, KRAS, NRAS, PIK3CA
SHC1 events in ERBB4 signalingR-HSA-12503475.154FGFR3, HRAS, KRAS, NRAS
Axon guidanceR-HSA-4224753.934FGFR3, HRAS, KRAS, NRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.074FGFR3, HRAS, KRAS, NRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.234HRAS, KRAS, NRAS, PIK3CA
HemostasisR-HSA-1095823.984HRAS, KRAS, NRAS, PIK3CA
C-type lectin receptors (CLRs)R-HSA-56214816.063HRAS, KRAS, NRAS
Negative regulation of MAPK pathwayR-HSA-56752217.663HRAS, KRAS, NRAS
p38MAPK eventsR-HSA-1710079.283HRAS, KRAS, NRAS
Regulation of RAS by GAPsR-HSA-56584426.923HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR1R-HSA-56546888.593HRAS, KRAS, NRAS
MAP2K and MAPK activationR-HSA-56741357.663HRAS, KRAS, NRAS
CD209 (DC-SIGN) signalingR-HSA-56215758.593HRAS, KRAS, NRAS
EGFR Transactivation by GastrinR-HSA-21793929.813HRAS, KRAS, NRAS
SHC-related events triggered by IGF1RR-HSA-24289339.813HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR2R-HSA-56546998.283HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR4R-HSA-56547198.463HRAS, KRAS, NRAS
Activation of RAS in B cellsR-HSA-116909210.663HRAS, KRAS, NRAS
RAF activationR-HSA-56730008.343HRAS, KRAS, NRAS
PI3K/AKT activationR-HSA-1982036.322FGFR3, PIK3CA
PI3K/AKT Signaling in CancerR-HSA-22195286.562FGFR3, PIK3CA
PI3K CascadeR-HSA-1097046.682FGFR3, PIK3CA
PI-3K cascade:FGFR4R-HSA-56547206.372FGFR3, PIK3CA
PI-3K cascade:FGFR1R-HSA-56546896.372FGFR3, PIK3CA
PI3K events in ERBB4 signalingR-HSA-12503426.372FGFR3, PIK3CA
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.052FGFR3, PIK3CA
PI3K events in ERBB2 signalingR-HSA-19636426.372FGFR3, PIK3CA
PI-3K cascade:FGFR3R-HSA-56547106.372FGFR3, PIK3CA
GAB1 signalosomeR-HSA-1802926.312FGFR3, PIK3CA
PIP3 activates AKT signalingR-HSA-12576046.372FGFR3, PIK3CA
PI-3K cascade:FGFR2R-HSA-56546956.372FGFR3, PIK3CA
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
Interleukin-2 signaling (R-HSA-451927) -5.050.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
GAB1 signalosome (R-HSA-180292) -6.310.016FGFR3, HRAS, PIK3CA
Developmental Biology (R-HSA-1266738) -3.480.044FGFR3, HRAS, KRAS, NRAS
Signaling by VEGF (R-HSA-194138) -4.660.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
FCERI mediated MAPK activation (R-HSA-2871796) -4.320.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
IRS-mediated signalling (R-HSA-112399) -4.870.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.0HRAS, KRAS, NRAS, PIK3CA
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.0HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.0HRAS, KRAS, NRAS, PIK3CA
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFR (R-HSA-177929) -4.590.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.013FGFR3, HRAS, PIK3CA
SOS-mediated signalling (R-HSA-112412) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Tie2 Signaling (R-HSA-210993) -8.810.0HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by ERBB2 (R-HSA-1227986) -4.660.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI3K/AKT activation (R-HSA-198203) -6.320.015FGFR3, HRAS, PIK3CA
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Frs2-mediated activation (R-HSA-170968) -5.120.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.013FGFR3, HRAS, PIK3CA
Downstream signal transduction (R-HSA-186763) -4.650.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
RAF activation (R-HSA-5673000) -8.340.0HRAS, KRAS, NRAS
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR3 (R-HSA-5654704) -8.810.0FGFR3, HRAS, KRAS, NRAS
Activation of RAS in B cells (R-HSA-1169092) -10.660.0HRAS, KRAS, NRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR in disease (R-HSA-1226099) -7.490.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Innate Immune System (R-HSA-168249) -3.170.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.0FGFR3, HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933) -9.810.0HRAS, KRAS, NRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Prolonged ERK activation events (R-HSA-169893) -5.110.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR2 (R-HSA-5654738) -4.680.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.013FGFR3, HRAS, PIK3CA
PI3K Cascade (R-HSA-109704) -6.680.007FGFR3, HRAS, PIK3CA
DAP12 interactions (R-HSA-2172127) -4.560.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
EGFR Transactivation by Gastrin (R-HSA-2179392) -9.810.0HRAS, KRAS, NRAS
Axon guidance (R-HSA-422475) -3.930.013FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by Leptin (R-HSA-2586552) -5.10.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.002FGFR3, HRAS, PIK3CA
MAP2K and MAPK activation (R-HSA-5674135) -7.660.0HRAS, KRAS, NRAS
IGF1R signaling cascade (R-HSA-2428924) -4.850.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.0HRAS, KRAS, NRAS, PIK3CA
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by Insulin receptor (R-HSA-74752) -4.730.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Disease (R-HSA-1643685) -3.330.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Insulin receptor signalling cascade (R-HSA-74751) -4.850.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.013FGFR3, HRAS, PIK3CA
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.013FGFR3, HRAS, PIK3CA
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.0FGFR3, HRAS, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
C-type lectin receptors (CLRs) (R-HSA-5621481) -6.060.011HRAS, KRAS, NRAS
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.008FGFR3, HRAS, PIK3CA
Diseases of signal transduction (R-HSA-5663202) -4.890.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Immune System (R-HSA-168256) -2.370.04FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signalling to RAS (R-HSA-167044) -5.080.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.0FGFR3, HRAS, KRAS, NRAS
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.013FGFR3, HRAS, PIK3CA
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
ARMS-mediated activation (R-HSA-170984) -5.120.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.0HRAS, KRAS, NRAS
Signaling by FGFR1 (R-HSA-5654736) -4.690.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by PDGF (R-HSA-186797) -4.530.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
p38MAPK events (R-HSA-171007) -9.280.0HRAS, KRAS, NRAS
Signaling by Interleukins (R-HSA-449147) -4.710.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Cell surface interactions at the vascular wall (R-HSA-202733) -6.320.0HRAS, KRAS, NRAS, PIK3CA
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.009FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by ERBB4 (R-HSA-1236394) -4.70.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Adaptive Immune System (R-HSA-1280218) -3.190.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
MAPK family signaling cascades (R-HSA-5683057) -4.890.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signalling by NGF (R-HSA-166520) -4.230.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR4 (R-HSA-5654743) -4.690.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR3 (R-HSA-5654741) -4.690.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR (R-HSA-190236) -4.670.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by SCF-KIT (R-HSA-1433557) -4.730.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
DAP12 signaling (R-HSA-2424491) -4.640.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.0HRAS, KRAS, NRAS, PIK3CA
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.0HRAS, KRAS, NRAS
Regulation of RAS by GAPs (R-HSA-5658442) -6.920.001HRAS, KRAS, NRAS
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.013FGFR3, HRAS, PIK3CA
Signaling by GPCR (R-HSA-372790) -2.680.014FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signalling to ERKs (R-HSA-187687) -5.040.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.0HRAS, KRAS, NRAS, PIK3CA
Hemostasis (R-HSA-109582) -3.980.011HRAS, KRAS, NRAS, PIK3CA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.225FGFR3, HRAS, KRAS, NRAS, PIK3CA
organic cyclic compound binding (GO:0097159) 1.055FGFR3, HRAS, KRAS, NRAS, PIK3CA
nucleoside phosphate binding (GO:1901265) 1.965FGFR3, HRAS, KRAS, NRAS, PIK3CA
nucleotide binding (GO:0000166) 1.965FGFR3, HRAS, KRAS, NRAS, PIK3CA
small molecule binding (GO:0036094) 1.895FGFR3, HRAS, KRAS, NRAS, PIK3CA
carbohydrate derivative binding (GO:0097367) 2.035FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine ribonucleoside binding (GO:0032550) 2.225FGFR3, HRAS, KRAS, NRAS, PIK3CA
ribonucleotide binding (GO:0032553) 2.195FGFR3, HRAS, KRAS, NRAS, PIK3CA
binding (GO:0005488) 0.185FGFR3, HRAS, KRAS, NRAS, PIK3CA
protein binding (GO:0005515) 0.465FGFR3, HRAS, KRAS, NRAS, PIK3CA
ribonucleoside binding (GO:0032549) 2.225FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine ribonucleotide binding (GO:0032555) 2.25FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine nucleotide binding (GO:0017076) 2.195FGFR3, HRAS, KRAS, NRAS, PIK3CA
heterocyclic compound binding (GO:1901363) 1.065FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine nucleoside binding (GO:0001883) 2.225FGFR3, HRAS, KRAS, NRAS, PIK3CA
nucleoside binding (GO:0001882) 2.215FGFR3, HRAS, KRAS, NRAS, PIK3CA
catalytic activity (GO:0003824) 1.054FGFR3, HRAS, KRAS, PIK3CA
guanyl ribonucleotide binding (GO:0032561) 3.733HRAS, KRAS, NRAS
guanyl nucleotide binding (GO:0019001) 3.733HRAS, KRAS, NRAS
GTP binding (GO:0005525) 3.783HRAS, KRAS, NRAS
macromolecular complex binding (GO:0044877) 2.612KRAS, NRAS
phosphatidylinositol 3-kinase activity (GO:0035004) 5.492FGFR3, PIK3CA
molecular function regulator (GO:0098772) 2.512FGFR3, PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.612FGFR3, PIK3CA
pyrophosphatase activity (GO:0016462) 3.042HRAS, KRAS
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.562FGFR3, PIK3CA
transferase activity (GO:0016740) 1.952FGFR3, PIK3CA
protein kinase activity (GO:0004672) 3.272FGFR3, PIK3CA
protein complex binding (GO:0032403) 3.092KRAS, NRAS
ATP binding (GO:0005524) 2.432FGFR3, PIK3CA
hydrolase activity (GO:0016787) 1.92HRAS, KRAS
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.982FGFR3, PIK3CA
kinase activity (GO:0016301) 2.932FGFR3, PIK3CA
GTPase activity (GO:0003924) 4.312HRAS, KRAS
nucleoside-triphosphatase activity (GO:0017111) 3.092HRAS, KRAS
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032HRAS, KRAS
adenyl nucleotide binding (GO:0030554) 2.42FGFR3, PIK3CA
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082FGFR3, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772FGFR3, PIK3CA
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032HRAS, KRAS
phosphatidylinositol kinase activity (GO:0052742) 5.812FGFR3, PIK3CA
adenyl ribonucleotide binding (GO:0032559) 2.412FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
signaling receptor activity (GO:0038023) NEW2.490.026FGFR3, HRAS, KRAS, NRAS, PIK3CA
calcium-dependent protein binding (GO:0048306) NEW5.680.001HRAS, KRAS, PIK3CA
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
NAD+ kinase activity (GO:0003951) NEW9.050.012HRAS, KRAS
nucleoside phosphate binding (GO:1901265) -1.960.005FGFR3, HRAS, KRAS, NRAS, PIK3CA
nucleoside binding (GO:0001882) -2.210.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
anion binding (GO:0043168) NEW4.170.006FGFR3, HRAS, KRAS, NRAS, PIK3CA
receptor signaling protein activity (GO:0005057) NEW4.760.015FGFR3, HRAS, PIK3CA
nucleotide binding (GO:0000166) -1.960.005FGFR3, HRAS, KRAS, NRAS, PIK3CA
guanyl ribonucleotide binding (GO:0032561) -3.730.016HRAS, KRAS, NRAS, PIK3CA
purine nucleoside binding (GO:0001883) -2.220.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
ribonucleoside binding (GO:0032549) -2.220.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine nucleotide binding (GO:0017076) -2.190.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
diacylglycerol kinase activity (GO:0004143) NEW7.340.01HRAS, KRAS
GTP binding (GO:0005525) -3.780.012HRAS, KRAS, NRAS, PIK3CA
NF-kappaB binding (GO:0051059) NEW6.340.014HRAS, KRAS
small molecule binding (GO:0036094) -1.890.007FGFR3, HRAS, KRAS, NRAS, PIK3CA
phosphatase binding (GO:0019902) NEW4.630.022HRAS, KRAS, PIK3CA
binding, bridging (GO:0060090) NEW4.570.0HRAS, KRAS, NRAS, PIK3CA
protein binding, bridging (GO:0030674) NEW4.680.027HRAS, KRAS, NRAS
growth factor receptor binding (GO:0070851) NEW4.870.01FGFR3, HRAS, PIK3CA
carbohydrate derivative binding (GO:0097367) -2.030.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
phosphatidylserine binding (GO:0001786) NEW6.240.023HRAS, KRAS
guanyl nucleotide binding (GO:0019001) -3.730.016HRAS, KRAS, NRAS, PIK3CA
purine ribonucleotide binding (GO:0032555) -2.20.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
purine ribonucleoside binding (GO:0032550) -2.220.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
ribonucleotide binding (GO:0032553) -2.190.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
phosphorylation (GO:0016310) 2.635FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of response to stimulus (GO:0048584) 2.185FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of response to stimulus (GO:0048583) 1.545FGFR3, HRAS, KRAS, NRAS, PIK3CA
signal transduction (GO:0007165) 1.285FGFR3, HRAS, KRAS, NRAS, PIK3CA
cell surface receptor signaling pathway (GO:0007166) 2.095FGFR3, HRAS, KRAS, NRAS, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167) 3.245FGFR3, HRAS, KRAS, NRAS, PIK3CA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.545FGFR3, HRAS, KRAS, NRAS, PIK3CA
intracellular signal transduction (GO:0035556) 2.395FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of biological process (GO:0050789) 0.455FGFR3, HRAS, KRAS, NRAS, PIK3CA
single-organism process (GO:0044699) 0.485FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular protein metabolic process (GO:0044267) 1.635FGFR3, HRAS, KRAS, NRAS, PIK3CA
single-organism metabolic process (GO:0044710) 1.635FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular macromolecule metabolic process (GO:0044260) 0.935FGFR3, HRAS, KRAS, NRAS, PIK3CA
organic substance metabolic process (GO:0071704) 0.635FGFR3, HRAS, KRAS, NRAS, PIK3CA
biological regulation (GO:0065007) 0.395FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of biological process (GO:0048518) 1.25FGFR3, HRAS, KRAS, NRAS, PIK3CA
protein phosphorylation (GO:0006468) 2.895FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular process (GO:0009987) 0.265FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular protein modification process (GO:0006464) 1.795FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of cellular process (GO:0050794) 0.55FGFR3, HRAS, KRAS, NRAS, PIK3CA
macromolecule modification (GO:0043412) 1.735FGFR3, HRAS, KRAS, NRAS, PIK3CA
protein modification process (GO:0036211) 1.795FGFR3, HRAS, KRAS, NRAS, PIK3CA
single-organism cellular process (GO:0044763) 0.655FGFR3, HRAS, KRAS, NRAS, PIK3CA
metabolic process (GO:0008152) 0.585FGFR3, HRAS, KRAS, NRAS, PIK3CA
primary metabolic process (GO:0044238) 0.695FGFR3, HRAS, KRAS, NRAS, PIK3CA
protein metabolic process (GO:0019538) 1.455FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular metabolic process (GO:0044237) 0.695FGFR3, HRAS, KRAS, NRAS, PIK3CA
macromolecule metabolic process (GO:0043170) 0.835FGFR3, HRAS, KRAS, NRAS, PIK3CA
phosphate-containing compound metabolic process (GO:0006796) 2.165FGFR3, HRAS, KRAS, NRAS, PIK3CA
phosphorus metabolic process (GO:0006793) 2.155FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of phosphate metabolic process (GO:0019220) 2.354FGFR3, HRAS, KRAS, PIK3CA
positive regulation of metabolic process (GO:0009893) 1.744FGFR3, HRAS, KRAS, PIK3CA
regulation of metabolic process (GO:0019222) 1.024FGFR3, HRAS, KRAS, PIK3CA
positive regulation of kinase activity (GO:0033674) 3.544FGFR3, HRAS, KRAS, PIK3CA
MAPK cascade (GO:0000165) 3.914FGFR3, HRAS, KRAS, NRAS
positive regulation of cellular metabolic process (GO:0031325) 1.814FGFR3, HRAS, KRAS, PIK3CA
regulation of cellular metabolic process (GO:0031323) 1.074FGFR3, HRAS, KRAS, PIK3CA
movement of cell or subcellular component (GO:0006928) 2.614HRAS, KRAS, NRAS, PIK3CA
leukocyte migration (GO:0050900) 4.194HRAS, KRAS, NRAS, PIK3CA
ERBB signaling pathway (GO:0038127) 5.364HRAS, KRAS, NRAS, PIK3CA
regulation of signaling (GO:0023051) 1.724FGFR3, HRAS, KRAS, PIK3CA
ERBB2 signaling pathway (GO:0038128) 6.094HRAS, KRAS, NRAS, PIK3CA
regulation of cell communication (GO:0010646) 1.734FGFR3, HRAS, KRAS, PIK3CA
signal transduction by protein phosphorylation (GO:0023014) 3.794FGFR3, HRAS, KRAS, NRAS
regulation of primary metabolic process (GO:0080090) 1.084FGFR3, HRAS, KRAS, PIK3CA
positive regulation of transferase activity (GO:0051347) 3.314FGFR3, HRAS, KRAS, PIK3CA
immune response-regulating signaling pathway (GO:0002764) 3.724HRAS, KRAS, NRAS, PIK3CA
regulation of signal transduction (GO:0009966) 1.844FGFR3, HRAS, KRAS, PIK3CA
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.964HRAS, KRAS, NRAS, PIK3CA
positive regulation of phosphorus metabolic process (GO:0010562) 2.784FGFR3, HRAS, KRAS, PIK3CA
regulation of kinase activity (GO:0043549) 3.074FGFR3, HRAS, KRAS, PIK3CA
regulation of protein metabolic process (GO:0051246) 1.934FGFR3, HRAS, KRAS, PIK3CA
positive regulation of protein metabolic process (GO:0051247) 2.434FGFR3, HRAS, KRAS, PIK3CA
positive regulation of immune system process (GO:0002684) 2.964HRAS, KRAS, NRAS, PIK3CA
regulation of cellular protein metabolic process (GO:0032268) 1.994FGFR3, HRAS, KRAS, PIK3CA
regulation of immune system process (GO:0002682) 2.54HRAS, KRAS, NRAS, PIK3CA
positive regulation of catalytic activity (GO:0043085) 2.44FGFR3, HRAS, KRAS, PIK3CA
positive regulation of molecular function (GO:0044093) 2.234FGFR3, HRAS, KRAS, PIK3CA
regulation of protein modification process (GO:0031399) 2.324FGFR3, HRAS, KRAS, PIK3CA
negative regulation of biological process (GO:0048519) 1.334FGFR3, HRAS, KRAS, PIK3CA
regulation of molecular function (GO:0065009) 1.784FGFR3, HRAS, KRAS, PIK3CA
cell migration (GO:0016477) 3.124HRAS, KRAS, NRAS, PIK3CA
developmental process (GO:0032502) 1.364FGFR3, HRAS, KRAS, PIK3CA
locomotion (GO:0040011) 2.914HRAS, KRAS, NRAS, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270) 2.494FGFR3, HRAS, KRAS, PIK3CA
regulation of immune response (GO:0050776) 2.984HRAS, KRAS, NRAS, PIK3CA
positive regulation of phosphate metabolic process (GO:0045937) 2.784FGFR3, HRAS, KRAS, PIK3CA
regulation of macromolecule metabolic process (GO:0060255) 1.084FGFR3, HRAS, KRAS, PIK3CA
regulation of catalytic activity (GO:0050790) 1.974FGFR3, HRAS, KRAS, PIK3CA
single-organism developmental process (GO:0044767) 1.494FGFR3, HRAS, KRAS, PIK3CA
immune response-activating signal transduction (GO:0002757) 3.84HRAS, KRAS, NRAS, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173) 5.724HRAS, KRAS, NRAS, PIK3CA
Fc-epsilon receptor signaling pathway (GO:0038095) 4.844HRAS, KRAS, NRAS, PIK3CA
regulation of intracellular signal transduction (GO:1902531) 2.314FGFR3, HRAS, KRAS, PIK3CA
positive regulation of macromolecule metabolic process (GO:0010604) 1.814FGFR3, HRAS, KRAS, PIK3CA
regulation of phosphorylation (GO:0042325) 2.54FGFR3, HRAS, KRAS, PIK3CA
regulation of phosphorus metabolic process (GO:0051174) 2.354FGFR3, HRAS, KRAS, PIK3CA
positive regulation of phosphorylation (GO:0042327) 2.94FGFR3, HRAS, KRAS, PIK3CA
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.064HRAS, KRAS, NRAS, PIK3CA
Fc receptor signaling pathway (GO:0038093) 4.454HRAS, KRAS, NRAS, PIK3CA
cell motility (GO:0048870) 3.024HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein modification process (GO:0031401) 2.74FGFR3, HRAS, KRAS, PIK3CA
positive regulation of immune response (GO:0050778) 3.44HRAS, KRAS, NRAS, PIK3CA
regulation of transferase activity (GO:0051338) 2.884FGFR3, HRAS, KRAS, PIK3CA
immune system process (GO:0002376) 2.294HRAS, KRAS, NRAS, PIK3CA
activation of immune response (GO:0002253) 3.674HRAS, KRAS, NRAS, PIK3CA
regulation of protein phosphorylation (GO:0001932) 2.574FGFR3, HRAS, KRAS, PIK3CA
positive regulation of protein phosphorylation (GO:0001934) 2.954FGFR3, HRAS, KRAS, PIK3CA
positive regulation of cellular process (GO:0048522) 1.34FGFR3, HRAS, KRAS, PIK3CA
regulation of cell proliferation (GO:0042127) 2.413FGFR3, HRAS, KRAS
positive regulation of defense response (GO:0031349) 3.833HRAS, KRAS, NRAS
regulation of neuron apoptotic process (GO:0043523) 4.473HRAS, KRAS, PIK3CA
negative regulation of neuron apoptotic process (GO:0043524) 4.823HRAS, KRAS, PIK3CA
axon guidance (GO:0007411) 4.443HRAS, KRAS, NRAS
positive regulation of cell communication (GO:0010647) 2.413FGFR3, HRAS, KRAS
anatomical structure morphogenesis (GO:0009653) 2.533FGFR3, HRAS, KRAS
regulation of apoptotic process (GO:0042981) 2.53HRAS, KRAS, PIK3CA
Ras protein signal transduction (GO:0007265) 4.763HRAS, KRAS, NRAS
cellular component organization or biogenesis (GO:0071840) 1.223HRAS, KRAS, PIK3CA
regulation of MAPK cascade (GO:0043408) 3.223FGFR3, HRAS, KRAS
negative regulation of neuron death (GO:1901215) 4.573HRAS, KRAS, PIK3CA
cellular developmental process (GO:0048869) 1.823FGFR3, HRAS, KRAS
cellular component organization (GO:0016043) 1.243HRAS, KRAS, PIK3CA
neuron projection guidance (GO:0097485) 4.433HRAS, KRAS, NRAS
regulation of programmed cell death (GO:0043067) 2.493HRAS, KRAS, PIK3CA
negative regulation of apoptotic process (GO:0043066) 3.043HRAS, KRAS, PIK3CA
regulation of defense response (GO:0031347) 3.113HRAS, KRAS, NRAS
regulation of biological quality (GO:0065008) 1.683HRAS, KRAS, PIK3CA
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.073HRAS, KRAS, NRAS
regulation of gene expression (GO:0010468) 1.373HRAS, KRAS, PIK3CA
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.093HRAS, KRAS, NRAS
positive regulation of cell proliferation (GO:0008284) 3.013FGFR3, HRAS, KRAS
multicellular organismal process (GO:0032501) 1.453FGFR3, KRAS, PIK3CA
positive regulation of innate immune response (GO:0045089) 4.223HRAS, KRAS, NRAS
regulation of innate immune response (GO:0045088) 3.863HRAS, KRAS, NRAS
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433HRAS, KRAS, PIK3CA
negative regulation of cell death (GO:0060548) 2.953HRAS, KRAS, PIK3CA
regulation of protein kinase activity (GO:0045859) 3.153HRAS, KRAS, PIK3CA
small GTPase mediated signal transduction (GO:0007264) 3.853HRAS, KRAS, NRAS
positive regulation of MAPK cascade (GO:0043410) 3.573FGFR3, HRAS, KRAS
regulation of nitrogen compound metabolic process (GO:0051171) 1.363HRAS, KRAS, PIK3CA
positive regulation of intracellular signal transduction (GO:1902533) 2.953FGFR3, HRAS, KRAS
regulation of neuron death (GO:1901214) 4.193HRAS, KRAS, PIK3CA
establishment of localization (GO:0051234) 1.483HRAS, NRAS, PIK3CA
localization (GO:0051179) 1.43HRAS, NRAS, PIK3CA
positive regulation of signaling (GO:0023056) 2.413FGFR3, HRAS, KRAS
single-multicellular organism process (GO:0044707) 1.783FGFR3, KRAS, PIK3CA
negative regulation of programmed cell death (GO:0043069) 3.023HRAS, KRAS, PIK3CA
response to stimulus (GO:0050896) 1.223HRAS, KRAS, PIK3CA
anatomical structure development (GO:0048856) 1.583FGFR3, KRAS, PIK3CA
innate immune response-activating signal transduction (GO:0002758) 4.453HRAS, KRAS, NRAS
activation of innate immune response (GO:0002218) 4.413HRAS, KRAS, NRAS
positive regulation of signal transduction (GO:0009967) 2.53FGFR3, HRAS, KRAS
regulation of cell death (GO:0010941) 2.433HRAS, KRAS, PIK3CA
positive regulation of protein kinase activity (GO:0045860) 3.613HRAS, KRAS, PIK3CA
regulation of response to stress (GO:0080134) 2.533HRAS, KRAS, NRAS
negative regulation of cellular process (GO:0048523) 1.413HRAS, KRAS, PIK3CA
behavior (GO:0007610) 3.472HRAS, KRAS
cellular response to stimulus (GO:0051716) 1.972HRAS, PIK3CA
single-organism biosynthetic process (GO:0044711) 2.82FGFR3, PIK3CA
phosphatidylinositol biosynthetic process (GO:0006661) 4.942FGFR3, PIK3CA
multi-organism process (GO:0051704) 2.652HRAS, KRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057) 6.042HRAS, KRAS
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082HRAS, KRAS
regulation of DNA metabolic process (GO:0051052) 3.872HRAS, PIK3CA
social behavior (GO:0035176) 5.92HRAS, KRAS
phosphatidylinositol metabolic process (GO:0046488) 4.462FGFR3, PIK3CA
regulation of RNA biosynthetic process (GO:2001141) 1.552HRAS, KRAS
intraspecies interaction between organisms (GO:0051703) 5.92HRAS, KRAS
glycerolipid metabolic process (GO:0046486) 3.912FGFR3, PIK3CA
response to organic substance (GO:0010033) 2.22KRAS, PIK3CA
multi-organism behavior (GO:0051705) 5.62HRAS, KRAS
system process (GO:0003008) 2.32KRAS, PIK3CA
single organism signaling (GO:0044700) 3.252FGFR3, KRAS
vesicle-mediated transport (GO:0016192) 2.722HRAS, PIK3CA
cellular biosynthetic process (GO:0044249) 1.372FGFR3, PIK3CA
organophosphate metabolic process (GO:0019637) 3.042FGFR3, PIK3CA
regulation of synaptic plasticity (GO:0048167) 4.782HRAS, KRAS
positive regulation of gene expression (GO:0010628) 2.352HRAS, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062HRAS, KRAS
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582HRAS, KRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) 6.552HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168) 5.842HRAS, KRAS
organic substance biosynthetic process (GO:1901576) 1.342FGFR3, PIK3CA
positive regulation of GTPase activity (GO:0043547) 3.282FGFR3, HRAS
positive regulation of hydrolase activity (GO:0051345) 2.912FGFR3, HRAS
phosphatidylinositol phosphorylation (GO:0046854) 5.192FGFR3, PIK3CA
organ morphogenesis (GO:0009887) 3.552FGFR3, HRAS
lipid metabolic process (GO:0006629) 2.682FGFR3, PIK3CA
regulation of developmental process (GO:0050793) 2.12FGFR3, PIK3CA
transport (GO:0006810) 1.512HRAS, PIK3CA
regulation of biosynthetic process (GO:0009889) 1.372HRAS, KRAS
tissue development (GO:0009888) 3.272FGFR3, PIK3CA
programmed cell death (GO:0012501) 3.12FGFR3, HRAS
regulation of multicellular organismal process (GO:0051239) 1.872HRAS, PIK3CA
glycerophospholipid biosynthetic process (GO:0046474) 4.622FGFR3, PIK3CA
organophosphate biosynthetic process (GO:0090407) 3.672FGFR3, PIK3CA
inositol lipid-mediated signaling (GO:0048017) 4.912FGFR3, PIK3CA
regulation of hydrolase activity (GO:0051336) 2.532FGFR3, HRAS
endocytosis (GO:0006897) 3.692HRAS, PIK3CA
phospholipid biosynthetic process (GO:0008654) 4.392FGFR3, PIK3CA
regulation of transcription, DNA-templated (GO:0006355) 1.562HRAS, KRAS
regulation of macromolecule biosynthetic process (GO:0010556) 1.432HRAS, KRAS
regulation of developmental growth (GO:0048638) 4.042FGFR3, PIK3CA
regulation of synapse structure or activity (GO:0050803) 4.772HRAS, KRAS
cell differentiation (GO:0030154) 2.142FGFR3, KRAS
regulation of Ras protein signal transduction (GO:0046578) 4.492HRAS, KRAS
positive regulation of Ras protein signal transduction (GO:0046579) 6.22HRAS, KRAS
modulation of synaptic transmission (GO:0050804) 4.092HRAS, KRAS
positive regulation of MAP kinase activity (GO:0043406) 4.392HRAS, KRAS
regulation of MAP kinase activity (GO:0043405) 3.952HRAS, KRAS
signaling (GO:0023052) 3.252FGFR3, KRAS
cell communication (GO:0007154) 3.042FGFR3, KRAS
regulation of GTPase activity (GO:0043087) 3.212FGFR3, HRAS
phosphatidylinositol-mediated signaling (GO:0048015) 4.932FGFR3, PIK3CA
lipid phosphorylation (GO:0046834) 5.132FGFR3, PIK3CA
phospholipid metabolic process (GO:0006644) 3.882FGFR3, PIK3CA
cell proliferation (GO:0008283) 3.232FGFR3, HRAS
regulation of nucleic acid-templated transcription (GO:1903506) 1.552HRAS, KRAS
cellular lipid metabolic process (GO:0044255) 2.922FGFR3, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792FGFR3, PIK3CA
lipid modification (GO:0030258) 4.372FGFR3, PIK3CA
regulation of RNA metabolic process (GO:0051252) 1.522HRAS, KRAS
system development (GO:0048731) 2.922FGFR3, PIK3CA
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562FGFR3, HRAS
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232FGFR3, HRAS
glycerophospholipid metabolic process (GO:0006650) 4.132FGFR3, PIK3CA
regulation of cellular biosynthetic process (GO:0031326) 1.382HRAS, KRAS
apoptotic signaling pathway (GO:0097190) 4.122FGFR3, HRAS
homeostatic process (GO:0042592) 2.612KRAS, PIK3CA
cell death (GO:0008219) 3.052FGFR3, HRAS
glycerolipid biosynthetic process (GO:0045017) 4.532FGFR3, PIK3CA
regulation of growth (GO:0040008) 3.262FGFR3, PIK3CA
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462HRAS, KRAS
antigen receptor-mediated signaling pathway (GO:0050851) 4.432HRAS, PIK3CA
T cell receptor signaling pathway (GO:0050852) 4.712HRAS, PIK3CA
apoptotic process (GO:0006915) 3.142FGFR3, HRAS
biosynthetic process (GO:0009058) 1.322FGFR3, PIK3CA
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.842FGFR3, PIK3CA
cell-cell signaling (GO:0007267) 3.352FGFR3, KRAS
response to chemical (GO:0042221) 1.982KRAS, PIK3CA
lipid biosynthetic process (GO:0008610) 3.492FGFR3, PIK3CA
organelle organization (GO:0006996) 2.022KRAS, PIK3CA
single-organism organelle organization (GO:1902589) 2.682KRAS, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
hemostasis (GO:0007599) NEW4.50.001HRAS, KRAS, NRAS, PIK3CA
blood coagulation (GO:0007596) NEW4.520.001HRAS, KRAS, NRAS, PIK3CA
learning (GO:0007612) NEW4.850.002HRAS, KRAS, NRAS
activation of protein kinase activity (GO:0032147) NEW4.080.016HRAS, KRAS, NRAS, PIK3CA
learning or memory (GO:0007611) NEW4.330.008HRAS, KRAS, NRAS
skeletal system development (GO:0001501) NEW4.490.008FGFR3, HRAS, KRAS, PIK3CA
regulation of Wnt signaling pathway (GO:0030111) NEW3.980.019FGFR3, HRAS, NRAS, PIK3CA
regulation of neuron apoptotic process (GO:0043523) -4.470.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of neuron apoptotic process (GO:0043524) -4.820.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.044FGFR3, HRAS, KRAS, NRAS, PIK3CA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
signal transduction by phosphorylation (GO:0023014) -3.790.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of cell cycle (GO:0045786) NEW3.670.024FGFR3, HRAS, KRAS, PIK3CA
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.015FGFR3, HRAS, KRAS, NRAS, PIK3CA
taxis (GO:0042330) NEW4.030.025FGFR3, HRAS, KRAS, PIK3CA
positive regulation of signal transduction (GO:0009967) -2.50.033FGFR3, HRAS, KRAS, NRAS
MAPK cascade (GO:0000165) -3.910.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to growth factor (GO:0070848) NEW4.140.016FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to insulin (GO:0032868) NEW4.720.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of molecular function (GO:0044093) -2.230.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of cell development (GO:0010721) NEW4.020.006FGFR3, HRAS, KRAS, PIK3CA
positive regulation of phosphate metabolic process (GO:0045937) -2.780.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of small GTPase mediated signal transduction (GO:0051057) -6.040.0HRAS, KRAS, NRAS
regulation of small GTPase mediated signal transduction (GO:0051056) -4.080.012HRAS, KRAS, NRAS, PIK3CA
leukocyte chemotaxis (GO:0030595) NEW4.960.044HRAS, KRAS, PIK3CA
positive regulation of response to stimulus (GO:0048584) -2.180.004FGFR3, HRAS, KRAS, NRAS, PIK3CA
neurotrophin signaling pathway (GO:0038179) NEW6.550.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
chemotaxis (GO:0006935) NEW4.040.025FGFR3, HRAS, KRAS, PIK3CA
social behavior (GO:0035176) -5.90.032HRAS, KRAS
negative regulation of cell death (GO:0060548) -2.950.008HRAS, KRAS, NRAS, PIK3CA
regulation of protein kinase activity (GO:0045859) -3.150.04FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of cellular protein metabolic process (GO:0032268) -1.990.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
intraspecies interaction between organisms (GO:0051703) -5.90.032HRAS, KRAS
response to peptide hormone (GO:0043434) NEW4.060.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
neuron projection guidance (GO:0097485) -4.430.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to organic substance (GO:0010033) -2.20.019FGFR3, HRAS, KRAS, NRAS, PIK3CA
system process (GO:0003008) -2.30.042HRAS, KRAS, NRAS, PIK3CA
regulation of phosphorylation (GO:0042325) -2.50.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of phosphorylation (GO:0042327) -2.90.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
cell motility (GO:0048870) -3.020.008HRAS, KRAS, NRAS, PIK3CA
single-organism behavior (GO:0044708) NEW3.790.046HRAS, KRAS, NRAS
response to organonitrogen compound (GO:0010243) NEW3.20.037FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of synaptic transmission, GABAergic (GO:0032228) NEW6.360.0HRAS, KRAS, NRAS
immune system process (GO:0002376) -2.290.007FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to light stimulus (GO:0009416) NEW4.080.033HRAS, KRAS, NRAS
muscle cell differentiation (GO:0042692) NEW5.090.002HRAS, KRAS, NRAS
visual behavior (GO:0007632) NEW5.820.008HRAS, KRAS, NRAS
positive regulation of metabolic process (GO:0009893) -1.740.026FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of kinase activity (GO:0033674) -3.540.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of synaptic plasticity (GO:0048167) -4.780.002HRAS, KRAS, NRAS
morphogenesis of a branching structure (GO:0001763) NEW4.710.005HRAS, KRAS, NRAS
intracellular signal transduction (GO:0035556) -2.390.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of apoptotic process (GO:0042981) -2.50.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of neuronal synaptic plasticity (GO:0048168) -5.840.0HRAS, KRAS, NRAS
positive regulation of transferase activity (GO:0051347) -3.310.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
immune response-regulating signaling pathway (GO:0002764) -3.720.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of kinase activity (GO:0043549) -3.070.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
guanosine-containing compound catabolic process (GO:1901069) NEW8.630.011HRAS, KRAS, NRAS, PIK3CA
guanosine-containing compound metabolic process (GO:1901068) NEW5.90.017HRAS, KRAS, NRAS, PIK3CA
cellular response to chemical stimulus (GO:0070887) NEW2.570.009FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of immune system process (GO:0002682) -2.50.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of immune system process (GO:0002683) NEW3.850.034FGFR3, HRAS, KRAS, PIK3CA
negative regulation of developmental growth (GO:0048640) NEW5.250.004FGFR3, HRAS, KRAS
regulation of molecular function (GO:0065009) -1.780.032FGFR3, HRAS, KRAS, NRAS, PIK3CA
cell migration (GO:0016477) -3.120.005HRAS, KRAS, NRAS, PIK3CA
regulation of catalytic activity (GO:0050790) -1.970.013FGFR3, HRAS, KRAS, NRAS, PIK3CA
defense response (GO:0006952) NEW2.780.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
associative learning (GO:0008306) NEW5.440.018HRAS, KRAS, NRAS
immune response (GO:0006955) NEW2.860.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of neuron death (GO:1901214) -4.190.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of neuron death (GO:1901215) -4.570.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of MAPK cascade (GO:0043410) -3.570.047FGFR3, HRAS, KRAS
Fc-epsilon receptor signaling pathway (GO:0038095) -4.840.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
Fc receptor signaling pathway (GO:0038093) -4.450.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to nitrogen compound (GO:1901698) NEW3.120.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein modification process (GO:0031401) -2.70.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
cognition (GO:0050890) NEW4.20.012HRAS, KRAS, NRAS
regulation of transferase activity (GO:0051338) -2.880.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
coagulation (GO:0050817) NEW4.510.001HRAS, KRAS, NRAS, PIK3CA
response to fibroblast growth factor (GO:0071774) NEW6.170.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of lipase activity (GO:0060193) NEW5.540.026FGFR3, HRAS, PIK3CA
phosphorylation (GO:0016310) -2.630.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of Ras protein signal transduction (GO:0046578) -4.490.001HRAS, KRAS, NRAS, PIK3CA
positive regulation of Ras protein signal transduction (GO:0046579) -6.20.001HRAS, KRAS, NRAS
regulation of synaptic transmission (GO:0050804) -4.090.013HRAS, KRAS, NRAS, PIK3CA
positive regulation of signaling (GO:0023056) -2.410.04FGFR3, HRAS, KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020) NEW7.240.0HRAS, KRAS, NRAS
ERBB signaling pathway (GO:0038127) -5.360.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of Rac protein signal transduction (GO:0035022) NEW8.630.0HRAS, KRAS, NRAS
positive regulation of intracellular signal transduction (GO:1902533) -2.950.038FGFR3, HRAS, KRAS, NRAS, PIK3CA
axon guidance (GO:0007411) -4.440.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of cell communication (GO:0010647) -2.410.041FGFR3, HRAS, KRAS, NRAS
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
visual learning (GO:0008542) NEW5.920.0HRAS, KRAS, NRAS
positive regulation of catalytic activity (GO:0043085) -2.40.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of MAPK cascade (GO:0043408) -3.220.002FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to endogenous stimulus (GO:0009719) NEW2.790.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to peptide hormone stimulus (GO:0071375) NEW4.630.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of protein metabolic process (GO:0051246) -1.930.009FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein metabolic process (GO:0051247) -2.430.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of neurogenesis (GO:0050768) NEW4.220.002FGFR3, HRAS, KRAS, PIK3CA
regulation of protein modification by small protein conjugation or removal (GO:1903320) NEW4.140.004FGFR3, HRAS, KRAS, PIK3CA
epithelial tube branching involved in lung morphogenesis (GO:0060441) NEW6.90.0HRAS, KRAS, NRAS
positive regulation of protein modification by small protein conjugation or removal (GO:1903322) NEW4.480.001FGFR3, HRAS, KRAS, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270) -2.490.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein ubiquitination (GO:0031398) NEW4.550.044FGFR3, HRAS, KRAS
regulation of protein modification process (GO:0031399) -2.320.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of protein ubiquitination (GO:0031396) NEW4.220.002FGFR3, HRAS, KRAS, PIK3CA
positive regulation of cell proliferation (GO:0008284) -3.010.009FGFR3, HRAS, KRAS, NRAS
locomotion (GO:0040011) -2.910.014HRAS, KRAS, NRAS, PIK3CA
insulin receptor signaling pathway (GO:0008286) NEW5.330.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of body fluid levels (GO:0050878) NEW3.760.003HRAS, KRAS, NRAS, PIK3CA
negative regulation of cell differentiation (GO:0045596) NEW3.330.024FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to hormone stimulus (GO:0032870) NEW3.990.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
branching morphogenesis of an epithelial tube (GO:0048754) NEW4.930.003HRAS, KRAS, NRAS
negative regulation of developmental process (GO:0051093) NEW3.170.005FGFR3, HRAS, KRAS, NRAS
regulation of immune response (GO:0050776) -2.980.042FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to growth factor stimulus (GO:0071363) NEW4.270.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to hormone (GO:0009725) NEW3.330.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein kinase activity (GO:0045860) -3.610.001HRAS, KRAS, NRAS, PIK3CA
myeloid leukocyte migration (GO:0097529) NEW5.130.022HRAS, KRAS, PIK3CA
activation of MAPKK activity (GO:0000186) NEW5.740.005HRAS, KRAS, NRAS
cellular response to nitrogen compound (GO:1901699) NEW3.790.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of cellular metabolic process (GO:0031325) -1.810.02FGFR3, HRAS, KRAS, NRAS, PIK3CA
extrinsic apoptotic signaling pathway (GO:0097191) NEW5.160.037FGFR3, HRAS, PIK3CA
actin cytoskeleton organization (GO:0030036) NEW4.10.018HRAS, KRAS, NRAS, PIK3CA
leukocyte migration (GO:0050900) -4.190.009HRAS, KRAS, NRAS, PIK3CA
striated muscle cell differentiation (GO:0051146) NEW5.690.0HRAS, KRAS, NRAS
cellular response to insulin stimulus (GO:0032869) NEW5.290.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
GTP metabolic process (GO:0046039) NEW6.590.014HRAS, KRAS, NRAS, PIK3CA
regulation of cell death (GO:0010941) -2.430.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of phosphate metabolic process (GO:0019220) -2.350.007FGFR3, HRAS, KRAS, NRAS, PIK3CA
morphogenesis of an epithelium (GO:0002009) NEW4.080.0FGFR3, HRAS, KRAS, NRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) -6.550.0HRAS, KRAS, NRAS
cellular response to organonitrogen compound (GO:0071417) NEW3.870.003FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of programmed cell death (GO:0043067) -2.490.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to organic substance (GO:0071310) NEW2.780.004FGFR3, HRAS, KRAS, NRAS, PIK3CA
negative regulation of apoptotic process (GO:0043066) -3.040.006FGFR3, HRAS, KRAS, NRAS, PIK3CA
tissue morphogenesis (GO:0048729) NEW3.870.0FGFR3, HRAS, KRAS, NRAS
hematopoietic or lymphoid organ development (GO:0048534) NEW4.490.009FGFR3, HRAS, KRAS, PIK3CA
negative regulation of programmed cell death (GO:0043069) -3.020.006FGFR3, HRAS, KRAS, NRAS, PIK3CA
actin filament-based process (GO:0030029) NEW3.940.037HRAS, KRAS, NRAS, PIK3CA
morphogenesis of a branching epithelium (GO:0061138) NEW4.770.004HRAS, KRAS, NRAS
innate immune response (GO:0045087) NEW3.550.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of phosphorus metabolic process (GO:0051174) -2.350.007FGFR3, HRAS, KRAS, NRAS, PIK3CA
Ras protein signal transduction (GO:0007265) -4.760.003HRAS, KRAS, NRAS, PIK3CA
response to oxygen-containing compound (GO:1901700) NEW2.570.001FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to oxygen-containing compound (GO:1901701) NEW3.220.043FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to endogenous stimulus (GO:0071495) NEW3.330.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of phospholipase activity (GO:0010518) NEW5.760.017FGFR3, HRAS, PIK3CA
phosphate-containing compound metabolic process (GO:0006796) -2.160.03FGFR3, HRAS, KRAS, NRAS, PIK3CA
response to peptide (GO:1901652) NEW3.940.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
cellular response to peptide (GO:1901653) NEW4.520.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
phosphorus metabolic process (GO:0006793) -2.150.033FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of protein phosphorylation (GO:0001932) -2.570.0FGFR3, HRAS, KRAS, NRAS, PIK3CA
positive regulation of protein phosphorylation (GO:0001934) -2.950.035FGFR3, HRAS, KRAS, NRAS, PIK3CA
regulation of phospholipase activity (GO:0010517) NEW5.570.027FGFR3, HRAS, PIK3CA
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.285FGFR3, HRAS, KRAS, NRAS, PIK3CA
cytoplasmic part (GO:0044444) 0.825FGFR3, HRAS, KRAS, NRAS, PIK3CA
membrane (GO:0016020) 0.685FGFR3, HRAS, KRAS, NRAS, PIK3CA
cell part (GO:0044464) 0.115FGFR3, HRAS, KRAS, NRAS, PIK3CA
plasma membrane (GO:0005886) 1.395FGFR3, HRAS, KRAS, NRAS, PIK3CA
intracellular membrane-bounded organelle (GO:0043231) 0.64FGFR3, HRAS, KRAS, NRAS
intracellular organelle (GO:0043229) 0.514FGFR3, HRAS, KRAS, NRAS
membrane-bounded organelle (GO:0043227) 0.474FGFR3, HRAS, KRAS, NRAS
organelle (GO:0043226) 0.44FGFR3, HRAS, KRAS, NRAS
intracellular (GO:0005622) 2.374HRAS, KRAS, NRAS, PIK3CA
cytoplasm (GO:0005737) 1.013FGFR3, HRAS, KRAS
Golgi apparatus (GO:0005794) 2.73FGFR3, HRAS, NRAS
cytosol (GO:0005829) 1.683HRAS, KRAS, PIK3CA
membrane part (GO:0044425) 0.953FGFR3, KRAS, PIK3CA
organelle membrane (GO:0031090) 1.972HRAS, NRAS
Golgi membrane (GO:0000139) 3.282HRAS, NRAS
nucleus (GO:0005634) 1.072FGFR3, HRAS
anchoring junction (GO:0070161) 3.612FGFR3, KRAS
vesicle (GO:0031982) 1.642FGFR3, NRAS
membrane-bounded vesicle (GO:0031988) 1.712FGFR3, NRAS
intracellular organelle part (GO:0044446) 0.812HRAS, NRAS
Golgi apparatus part (GO:0044431) 3.02HRAS, NRAS
organelle part (GO:0044422) 0.792HRAS, NRAS
adherens junction (GO:0005912) 3.662FGFR3, KRAS
cell-substrate adherens junction (GO:0005924) 3.832FGFR3, KRAS
focal adhesion (GO:0005925) 3.832FGFR3, KRAS
plasma membrane part (GO:0044459) 1.952FGFR3, KRAS
bounding membrane of organelle (GO:0098588) 2.392HRAS, NRAS
cell junction (GO:0030054) 2.752FGFR3, KRAS
cell-substrate junction (GO:0030055) 3.822FGFR3, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
endosomal part (GO:0044440) NEW3.730.011HRAS, KRAS, NRAS, PIK3CA
extracellular matrix (GO:0031012) NEW3.810.004FGFR3, HRAS, KRAS, PIK3CA
cytosolic part (GO:0044445) NEW4.340.009HRAS, KRAS, PIK3CA
integral component of plasma membrane (GO:0005887) NEW2.570.023FGFR3, HRAS, KRAS, NRAS, PIK3CA
plasma membrane (GO:0005886) -1.390.021FGFR3, HRAS, KRAS, NRAS, PIK3CA
Golgi membrane (GO:0000139) -3.280.032HRAS, KRAS, NRAS, PIK3CA
endosome membrane (GO:0010008) NEW3.830.009HRAS, KRAS, NRAS, PIK3CA