Disease table of SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME OMIM ID: 163200

Gene-disease associations table

Gene	Associated with SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
HRAS	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.5	6	218040, 137550, 185500, 109800, 163200, 162900
NRAS	ClinVar, OMIM	HGNC link	1p13.2	8	137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
KRAS	ClinVar, OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs
HRAS	YES	3	SP1, MAZ, TP53
NRAS	YES	1	AR
KRAS	YES	1	MYC

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
HRAS	NRAS	No	7	RAP1GDS1, RABGGTB, MLLT4, RAF1, PIK3CG, RGL2, TMEM185A
HRAS	KRAS	No	10	RALGDS, RASSF5, RGL2, IL24, PIK3CA, BTRC, RAF1, PIK3CG, RAP1GDS1, SHOC2
NRAS	KRAS	No	6	RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
HRAS	KRAS	Yes	binding	111	RASA1, AKT1, RASSF4, TP53, MAP3K2, PIK3CA, EGFR, GAST, NCAM1, YWHAB, SPTAN1, PPARD, PTK2, MAPK14, RET, CALM1, SLC3A2, MAPK13, RPS6KB1, JUN, ETS2, ABL1, SPTBN5, CCR5, TNS4, MAPK3, BTRC, MTOR, FRS2, MAZ, MAP3K3, ARAF, KSR2, IL8, LGALS3, JUND, RASGRP3, SPTBN1, DDX43, TEK, KSR1, CNKSR3, SHC3, RGL4, NPM1, GRB2, RASGRF2, MAP3K19, RALGDS, SPTA1, RASA2, CDX1, SPRY2, UBC, MLLT4, MAP2K2, BMP4, NT5E, SPTBN4, HBEGF, FYN, RGL1, RASSF2, MAPK11, CCND1, SHC2, ERBB3, ETS1, RAF1, SHOC2, KIT, LGALS1, PTPRA, VEGFA, MAPK12, YES1, MGMT, SPTB, MEN1, RASGRP1, RASA3, PIK3CD, MDM4, PTPN11, PIK3CG, IGF2BP1, ANGPT1, ITSN1, MAP2K1, SOS1, EPHA2, ERBB2, MECOM, SHC1, MAPK7, NCL, AKT2, CDX2, SPTBN2, EGF, RASSF7, SRC, BCL2L11, NOTCH1, BCL2, MAPK1, PIK3CB, IRS1, IRS2, BRAF, ERBB4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
HRAS	NRAS	Yes	RAF1-RAS complex, EGF induced	2	KRAS, RAF1
HRAS	KRAS	Yes	RAF1-RAS complex, EGF induced	2	NRAS, RAF1
NRAS	KRAS	Yes	RAF1-RAS complex, EGF induced	2	HRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
HRAS	KRAS	No
HRAS	NRAS	maybe, indirect	They are member of the same protein family.
KRAS	NRAS	maybe, indirect	They are members of the same protein family.

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	3	HRAS, KRAS, NRAS
Bladder cancer	hsa05219	7.38	3	HRAS, KRAS, NRAS
Endometrial cancer	hsa05213	6.81	3	HRAS, KRAS, NRAS
Renal cell carcinoma	hsa05211	6.6	3	HRAS, KRAS, NRAS
Thyroid cancer	hsa05216	7.48	3	HRAS, KRAS, NRAS
Melanoma	hsa05218	6.56	3	HRAS, KRAS, NRAS
Glioma	hsa05214	6.66	3	HRAS, KRAS, NRAS
Prostate cancer	hsa05215	6.11	3	HRAS, KRAS, NRAS
Tight junction	hsa04530	5.53	3	HRAS, KRAS, NRAS
Long-term potentiation	hsa04720	6.64	3	HRAS, KRAS, NRAS
Neurotrophin signaling pathway	hsa04722	5.78	3	HRAS, KRAS, NRAS
Cholinergic synapse	hsa04725	5.88	3	HRAS, KRAS, NRAS
Choline metabolism in cancer	hsa05231	6.09	3	HRAS, KRAS, NRAS
FoxO signaling pathway	hsa04068	5.63	3	HRAS, KRAS, NRAS
Serotonergic synapse	hsa04726	5.84	3	HRAS, KRAS, NRAS
Chemokine signaling pathway	hsa04062	5.19	3	HRAS, KRAS, NRAS
Oxytocin signaling pathway	hsa04921	5.4	3	HRAS, KRAS, NRAS
Rap1 signaling pathway	hsa04015	4.97	3	HRAS, KRAS, NRAS
Natural killer cell mediated cytotoxicity	hsa04650	5.53	3	HRAS, KRAS, NRAS
HTLV-I infection	hsa05166	4.59	3	HRAS, KRAS, NRAS
PI3K-Akt signaling pathway	hsa04151	4.21	3	HRAS, KRAS, NRAS
Hepatitis C	hsa05160	5.68	3	HRAS, KRAS, NRAS
Hepatitis B	hsa05161	5.52	3	HRAS, KRAS, NRAS
Chronic myeloid leukemia	hsa05220	6.48	3	HRAS, KRAS, NRAS
Gap junction	hsa04540	6.24	3	HRAS, KRAS, NRAS
VEGF signaling pathway	hsa04370	6.77	3	HRAS, KRAS, NRAS
Proteoglycans in cancer	hsa05205	5.02	3	HRAS, KRAS, NRAS
MicroRNAs in cancer	hsa05206	5.38	3	HRAS, KRAS, NRAS
Pathways in cancer	hsa05200	3.98	3	HRAS, KRAS, NRAS
Viral carcinogenesis	hsa05203	5.08	3	HRAS, KRAS, NRAS
GnRH signaling pathway	hsa04912	6.18	3	HRAS, KRAS, NRAS
Insulin signaling pathway	hsa04910	5.55	3	HRAS, KRAS, NRAS
Ras signaling pathway	hsa04014	4.9	3	HRAS, KRAS, NRAS
Melanogenesis	hsa04916	5.97	3	HRAS, KRAS, NRAS
ErbB signaling pathway	hsa04012	6.15	3	HRAS, KRAS, NRAS
Acute myeloid leukemia	hsa05221	6.74	3	HRAS, KRAS, NRAS
Estrogen signaling pathway	hsa04915	6.11	3	HRAS, KRAS, NRAS
Thyroid hormone signaling pathway	hsa04919	5.82	3	HRAS, KRAS, NRAS
Long-term depression	hsa04730	6.74	3	HRAS, KRAS, NRAS
Regulation of actin cytoskeleton	hsa04810	4.9	3	HRAS, KRAS, NRAS
T cell receptor signaling pathway	hsa04660	6.01	3	HRAS, KRAS, NRAS
Non-small cell lung cancer	hsa05223	6.88	3	HRAS, KRAS, NRAS
MAPK signaling pathway	hsa04010	4.63	3	HRAS, KRAS, NRAS
B cell receptor signaling pathway	hsa04662	6.52	3	HRAS, KRAS, NRAS
Alcoholism	hsa05034	5.59	3	HRAS, KRAS, NRAS
Axon guidance	hsa04360	5.63	3	HRAS, KRAS, NRAS
Central carbon metabolism in cancer	hsa05230	6.7	3	HRAS, KRAS, NRAS
Fc epsilon RI signaling pathway	hsa04664	6.6	3	HRAS, KRAS, NRAS
Prolactin signaling pathway	hsa04917	6.6	3	HRAS, KRAS, NRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.006	HRAS, KRAS, NRAS
Bladder cancer (hsa05219)	-	7.38	0.0	HRAS, KRAS, NRAS
T cell receptor signaling pathway (hsa04660)	-	6.01	0.002	HRAS, KRAS, NRAS
Endometrial cancer (hsa05213)	-	6.81	0.0	HRAS, KRAS, NRAS
Renal cell carcinoma (hsa05211)	-	6.6	0.0	HRAS, KRAS, NRAS
Thyroid cancer (hsa05216)	-	7.48	0.0	HRAS, KRAS, NRAS
Melanoma (hsa05218)	-	6.56	0.0	HRAS, KRAS, NRAS
Glioma (hsa05214)	-	6.66	0.0	HRAS, KRAS, NRAS
Prostate cancer (hsa05215)	-	6.11	0.001	HRAS, KRAS, NRAS
Serotonergic synapse (hsa04726)	-	5.84	0.003	HRAS, KRAS, NRAS
Nervous system	NEW	3.77	0.029	HRAS, KRAS, NRAS
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.003	HRAS, KRAS, NRAS
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.0	HRAS, KRAS, NRAS
Choline metabolism in cancer (hsa05231)	-	6.09	0.002	HRAS, KRAS, NRAS
FoxO signaling pathway (hsa04068)	-	5.63	0.007	HRAS, KRAS, NRAS
Cellular community	NEW	3.57	0.044	HRAS, KRAS, NRAS
Chemokine signaling pathway (hsa04062)	-	5.19	0.001	HRAS, KRAS, NRAS
Oxytocin signaling pathway (hsa04921)	-	5.4	0.001	HRAS, KRAS, NRAS
Development	NEW	4.58	0.005	HRAS, KRAS, NRAS
Substance dependence	NEW	4.77	0.004	HRAS, KRAS, NRAS
Cholinergic synapse (hsa04725)	-	5.88	0.002	HRAS, KRAS, NRAS
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.001	HRAS, KRAS, NRAS
Circulatory system	NEW	4.63	0.038	HRAS, KRAS, NRAS
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.022	HRAS, KRAS, NRAS
Hepatitis C (hsa05160)	-	5.68	0.001	HRAS, KRAS, NRAS
Hepatitis B (hsa05161)	-	5.52	0.001	HRAS, KRAS, NRAS
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	HRAS, KRAS, NRAS
Cancers: Specific types	NEW	4.1	0.015	HRAS, KRAS, NRAS
Gap junction (hsa04540)	-	6.24	0.001	HRAS, KRAS, NRAS
VEGF signaling pathway (hsa04370)	-	6.77	0.0	HRAS, KRAS, NRAS
Proteoglycans in cancer (hsa05205)	-	5.02	0.002	HRAS, KRAS, NRAS
Estrogen signaling pathway (hsa04915)	-	6.11	0.001	HRAS, KRAS, NRAS
MicroRNAs in cancer (hsa05206)	-	5.38	0.007	HRAS, KRAS, NRAS
Pathways in cancer (hsa05200)	-	3.98	0.019	HRAS, KRAS, NRAS
Rap1 signaling pathway (hsa04015)	-	4.97	0.027	HRAS, KRAS, NRAS
GnRH signaling pathway (hsa04912)	-	6.18	0.0	HRAS, KRAS, NRAS
B cell receptor signaling pathway (hsa04662)	-	6.52	0.0	HRAS, KRAS, NRAS
Ras signaling pathway (hsa04014)	-	4.9	0.003	HRAS, KRAS, NRAS
Melanogenesis (hsa04916)	-	5.97	0.002	HRAS, KRAS, NRAS
ErbB signaling pathway (hsa04012)	-	6.15	0.0	HRAS, KRAS, NRAS
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	HRAS, KRAS, NRAS
MAPK signaling pathway (hsa04010)	-	4.63	0.039	HRAS, KRAS, NRAS
Viral carcinogenesis (hsa05203)	-	5.08	0.002	HRAS, KRAS, NRAS
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.0	HRAS, KRAS, NRAS
Cell motility	NEW	4.9	0.022	HRAS, KRAS, NRAS
HTLV-I infection (hsa05166)	-	4.59	0.005	HRAS, KRAS, NRAS
Long-term depression (hsa04730)	-	6.74	0.0	HRAS, KRAS, NRAS
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.012	HRAS, KRAS, NRAS
Tight junction (hsa04530)	-	5.53	0.001	HRAS, KRAS, NRAS
Long-term potentiation (hsa04720)	-	6.64	0.0	HRAS, KRAS, NRAS
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	HRAS, KRAS, NRAS
Insulin signaling pathway (hsa04910)	-	5.55	0.001	HRAS, KRAS, NRAS
Glycosphingolipid biosynthesis - lacto and neolacto series (hsa00601)	NEW	7.86	0.018	HRAS, KRAS
Alcoholism (hsa05034)	-	5.59	0.001	HRAS, KRAS, NRAS
Axon guidance (hsa04360)	-	5.63	0.001	HRAS, KRAS, NRAS
Fc epsilon RI signaling pathway (hsa04664)	-	6.6	0.0	HRAS, KRAS, NRAS
Prolactin signaling pathway (hsa04917)	-	6.6	0.0	HRAS, KRAS, NRAS

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Interleukin-2 signaling	R-HSA-451927	5.05	3	HRAS, KRAS, NRAS
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	3	HRAS, KRAS, NRAS
Developmental Biology	R-HSA-1266738	3.48	3	HRAS, KRAS, NRAS
Signaling by VEGF	R-HSA-194138	4.66	3	HRAS, KRAS, NRAS
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	HRAS, KRAS, NRAS
IRS-mediated signalling	R-HSA-112399	4.87	3	HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	3	HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	3	HRAS, KRAS, NRAS
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	3	HRAS, KRAS, NRAS
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	HRAS, KRAS, NRAS
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	3	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	HRAS, KRAS, NRAS
SOS-mediated signalling	R-HSA-112412	5.15	3	HRAS, KRAS, NRAS
Tie2 Signaling	R-HSA-210993	8.81	3	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.46	3	HRAS, KRAS, NRAS
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	HRAS, KRAS, NRAS
Immune System	R-HSA-168256	2.37	3	HRAS, KRAS, NRAS
Frs2-mediated activation	R-HSA-170968	5.12	3	HRAS, KRAS, NRAS
Downstream signal transduction	R-HSA-186763	4.65	3	HRAS, KRAS, NRAS
RAF activation	R-HSA-5673000	8.34	3	HRAS, KRAS, NRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	HRAS, KRAS, NRAS
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	HRAS, KRAS, NRAS
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	HRAS, KRAS, NRAS
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	HRAS, KRAS, NRAS
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.81	3	HRAS, KRAS, NRAS
Activation of RAS in B cells	R-HSA-1169092	10.66	3	HRAS, KRAS, NRAS
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	3	HRAS, KRAS, NRAS
Signaling by FGFR in disease	R-HSA-1226099	7.49	3	HRAS, KRAS, NRAS
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	HRAS, KRAS, NRAS
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	HRAS, KRAS, NRAS
Innate Immune System	R-HSA-168249	3.17	3	HRAS, KRAS, NRAS
Signaling by ERBB2	R-HSA-1227986	4.66	3	HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R	R-HSA-2428933	9.81	3	HRAS, KRAS, NRAS
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	HRAS, KRAS, NRAS
Prolonged ERK activation events	R-HSA-169893	5.11	3	HRAS, KRAS, NRAS
Signaling by FGFR2	R-HSA-5654738	4.68	3	HRAS, KRAS, NRAS
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	HRAS, KRAS, NRAS
Signaling by FGFR1	R-HSA-5654736	4.69	3	HRAS, KRAS, NRAS
DAP12 interactions	R-HSA-2172127	4.56	3	HRAS, KRAS, NRAS
EGFR Transactivation by Gastrin	R-HSA-2179392	9.81	3	HRAS, KRAS, NRAS
Axon guidance	R-HSA-422475	3.93	3	HRAS, KRAS, NRAS
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	3	HRAS, KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	HRAS, KRAS, NRAS
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	3	HRAS, KRAS, NRAS
Signaling by Leptin	R-HSA-2586552	5.1	3	HRAS, KRAS, NRAS
MAP2K and MAPK activation	R-HSA-5674135	7.66	3	HRAS, KRAS, NRAS
IGF1R signaling cascade	R-HSA-2428924	4.85	3	HRAS, KRAS, NRAS
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	HRAS, KRAS, NRAS
Signaling by Insulin receptor	R-HSA-74752	4.73	3	HRAS, KRAS, NRAS
Disease	R-HSA-1643685	3.33	3	HRAS, KRAS, NRAS
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.59	3	HRAS, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	HRAS, KRAS, NRAS
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	3	HRAS, KRAS, NRAS
Diseases of signal transduction	R-HSA-5663202	4.89	3	HRAS, KRAS, NRAS
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	HRAS, KRAS, NRAS
Signalling to RAS	R-HSA-167044	5.08	3	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.28	3	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	HRAS, KRAS, NRAS
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	HRAS, KRAS, NRAS
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	HRAS, KRAS, NRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	HRAS, KRAS, NRAS
Signaling by EGFR	R-HSA-177929	4.59	3	HRAS, KRAS, NRAS
ARMS-mediated activation	R-HSA-170984	5.12	3	HRAS, KRAS, NRAS
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.59	3	HRAS, KRAS, NRAS
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	HRAS, KRAS, NRAS
Signaling by PDGF	R-HSA-186797	4.53	3	HRAS, KRAS, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	HRAS, KRAS, NRAS
p38MAPK events	R-HSA-171007	9.28	3	HRAS, KRAS, NRAS
Signaling by Interleukins	R-HSA-449147	4.71	3	HRAS, KRAS, NRAS
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	3	HRAS, KRAS, NRAS
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	HRAS, KRAS, NRAS
Signaling by ERBB4	R-HSA-1236394	4.7	3	HRAS, KRAS, NRAS
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	HRAS, KRAS, NRAS
Adaptive Immune System	R-HSA-1280218	3.19	3	HRAS, KRAS, NRAS
MAPK family signaling cascades	R-HSA-5683057	4.89	3	HRAS, KRAS, NRAS
Signalling by NGF	R-HSA-166520	4.23	3	HRAS, KRAS, NRAS
Signaling by FGFR4	R-HSA-5654743	4.69	3	HRAS, KRAS, NRAS
Signaling by FGFR3	R-HSA-5654741	4.69	3	HRAS, KRAS, NRAS
Signaling by FGFR	R-HSA-190236	4.67	3	HRAS, KRAS, NRAS
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	HRAS, KRAS, NRAS
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	HRAS, KRAS, NRAS
DAP12 signaling	R-HSA-2424491	4.64	3	HRAS, KRAS, NRAS
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	HRAS, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	3	HRAS, KRAS, NRAS
Negative regulation of MAPK pathway	R-HSA-5675221	7.66	3	HRAS, KRAS, NRAS
Regulation of RAS by GAPs	R-HSA-5658442	6.92	3	HRAS, KRAS, NRAS
Signaling by GPCR	R-HSA-372790	2.68	3	HRAS, KRAS, NRAS
Signalling to ERKs	R-HSA-187687	5.04	3	HRAS, KRAS, NRAS
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	3	HRAS, KRAS, NRAS
Hemostasis	R-HSA-109582	3.98	3	HRAS, KRAS, NRAS
Signal Transduction	R-HSA-162582	1.78	3	HRAS, KRAS, NRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.024	HRAS, KRAS, NRAS
Signaling by the B Cell Receptor (BCR) (R-HSA-983705)	-	4.62	0.007	HRAS, KRAS, NRAS
Signaling by VEGF (R-HSA-194138)	-	4.66	0.006	HRAS, KRAS, NRAS
FCERI mediated MAPK activation (R-HSA-2871796)	-	4.32	0.013	HRAS, KRAS, NRAS
IRS-mediated signalling (R-HSA-112399)	-	4.87	0.004	HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815)	-	8.73	0.0	HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810)	-	9.08	0.0	HRAS, KRAS, NRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812)	-	9.08	0.0	HRAS, KRAS, NRAS
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.006	HRAS, KRAS, NRAS
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.0	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.006	HRAS, KRAS, NRAS
DAP12 interactions (R-HSA-2172127)	-	4.56	0.008	HRAS, KRAS, NRAS
Tie2 Signaling (R-HSA-210993)	-	8.81	0.0	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.006	HRAS, KRAS, NRAS
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.006	HRAS, KRAS, NRAS
VEGFR2 mediated cell proliferation (R-HSA-5218921)	-	5.07	0.003	HRAS, KRAS, NRAS
GRB2 events in ERBB2 signaling (R-HSA-1963640)	-	5.15	0.02	HRAS, KRAS, NRAS
Frs2-mediated activation (R-HSA-170968)	-	5.12	0.02	HRAS, KRAS, NRAS
Downstream signal transduction (R-HSA-186763)	-	4.65	0.007	HRAS, KRAS, NRAS
RAF activation (R-HSA-5673000)	-	8.34	0.0	HRAS, KRAS, NRAS
RAF/MAP kinase cascade (R-HSA-5673001)	-	5.15	0.02	HRAS, KRAS, NRAS
Signalling to p38 via RIT and RIN (R-HSA-187706)	-	5.12	0.021	HRAS, KRAS, NRAS
FRS-mediated FGFR2 signaling (R-HSA-5654700)	-	5.14	0.02	HRAS, KRAS, NRAS
SOS-mediated signalling (R-HSA-112412)	-	5.15	0.02	HRAS, KRAS, NRAS
FRS-mediated FGFR3 signaling (R-HSA-5654706)	-	5.14	0.02	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR3 (R-HSA-5654704)	-	8.81	0.0	HRAS, KRAS, NRAS
Activation of RAS in B cells (R-HSA-1169092)	-	10.66	0.0	HRAS, KRAS, NRAS
Signaling by EGFR in Cancer (R-HSA-1643713)	-	8.73	0.0	HRAS, KRAS, NRAS
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.0	HRAS, KRAS, NRAS
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.024	HRAS, KRAS, NRAS
Interleukin receptor SHC signaling (R-HSA-912526)	-	5.09	0.003	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR4 (R-HSA-5654719)	-	8.46	0.0	HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933)	-	9.81	0.0	HRAS, KRAS, NRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.009	HRAS, KRAS, NRAS
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.021	HRAS, KRAS, NRAS
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.006	HRAS, KRAS, NRAS
GRB2 events in EGFR signaling (R-HSA-179812)	-	5.15	0.02	HRAS, KRAS, NRAS
SHC1 events in ERBB4 signaling (R-HSA-1250347)	-	5.15	0.02	HRAS, KRAS, NRAS
FRS-mediated FGFR4 signaling (R-HSA-5654712)	-	5.14	0.02	HRAS, KRAS, NRAS
EGFR Transactivation by Gastrin (R-HSA-2179392)	-	9.81	0.0	HRAS, KRAS, NRAS
Axon guidance (R-HSA-422475)	-	3.93	0.029	HRAS, KRAS, NRAS
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.0	HRAS, KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.015	HRAS, KRAS, NRAS
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.0	HRAS, KRAS, NRAS
Signaling by Leptin (R-HSA-2586552)	-	5.1	0.022	HRAS, KRAS, NRAS
MAP2K and MAPK activation (R-HSA-5674135)	-	7.66	0.0	HRAS, KRAS, NRAS
IGF1R signaling cascade (R-HSA-2428924)	-	4.85	0.004	HRAS, KRAS, NRAS
IRS-related events triggered by IGF1R (R-HSA-2428928)	-	4.85	0.004	HRAS, KRAS, NRAS
Signaling by Insulin receptor (R-HSA-74752)	-	4.73	0.006	HRAS, KRAS, NRAS
Insulin receptor signalling cascade (R-HSA-74751)	-	4.85	0.004	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.006	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR1 (R-HSA-5654688)	-	8.59	0.0	HRAS, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.008	HRAS, KRAS, NRAS
C-type lectin receptors (CLRs) (R-HSA-5621481)	-	6.06	0.001	HRAS, KRAS, NRAS
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.004	HRAS, KRAS, NRAS
Signalling to RAS (R-HSA-167044)	-	5.08	0.023	HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR2 (R-HSA-5654699)	-	8.28	0.0	HRAS, KRAS, NRAS
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.006	HRAS, KRAS, NRAS
SHC1 events in EGFR signaling (R-HSA-180336)	-	5.15	0.02	HRAS, KRAS, NRAS
FRS-mediated FGFR1 signaling (R-HSA-5654693)	-	5.14	0.02	HRAS, KRAS, NRAS
SHC1 events in ERBB2 signaling (R-HSA-1250196)	-	5.15	0.02	HRAS, KRAS, NRAS
Signaling by EGFR (R-HSA-177929)	-	4.59	0.007	HRAS, KRAS, NRAS
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.021	HRAS, KRAS, NRAS
CD209 (DC-SIGN) signaling (R-HSA-5621575)	-	8.59	0.0	HRAS, KRAS, NRAS
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.006	HRAS, KRAS, NRAS
Signaling by PDGF (R-HSA-186797)	-	4.53	0.008	HRAS, KRAS, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192)	-	4.85	0.004	HRAS, KRAS, NRAS
p38MAPK events (R-HSA-171007)	-	9.28	0.0	HRAS, KRAS, NRAS
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.006	HRAS, KRAS, NRAS
Cell surface interactions at the vascular wall (R-HSA-202733)	-	6.32	0.0	HRAS, KRAS, NRAS
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.044	HRAS, KRAS, NRAS
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.006	HRAS, KRAS, NRAS
MAPK1/MAPK3 signaling (R-HSA-5684996)	-	5.11	0.021	HRAS, KRAS, NRAS
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.037	HRAS, KRAS, NRAS
Signalling by NGF (R-HSA-166520)	-	4.23	0.016	HRAS, KRAS, NRAS
Transport to the Golgi and subsequent modification (R-HSA-948021)	NEW	7.81	0.019	HRAS, KRAS
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.006	HRAS, KRAS, NRAS
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.006	HRAS, KRAS, NRAS
Signaling by FGFR (R-HSA-190236)	-	4.67	0.006	HRAS, KRAS, NRAS
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.006	HRAS, KRAS, NRAS
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.004	HRAS, KRAS, NRAS
DAP12 signaling (R-HSA-2424491)	-	4.64	0.007	HRAS, KRAS, NRAS
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.025	HRAS, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382)	-	8.73	0.0	HRAS, KRAS, NRAS
Negative regulation of MAPK pathway (R-HSA-5675221)	-	7.66	0.0	HRAS, KRAS, NRAS
Regulation of RAS by GAPs (R-HSA-5658442)	-	6.92	0.0	HRAS, KRAS, NRAS
Signalling to ERKs (R-HSA-187687)	-	5.04	0.026	HRAS, KRAS, NRAS
Signaling by FGFR4 in disease (R-HSA-5655291)	-	9.52	0.0	HRAS, KRAS, NRAS
Hemostasis (R-HSA-109582)	-	3.98	0.027	HRAS, KRAS, NRAS

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
protein binding (GO:0005515)	0.46	3	HRAS, KRAS, NRAS
guanyl nucleotide binding (GO:0019001)	3.73	3	HRAS, KRAS, NRAS
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	HRAS, KRAS, NRAS
carbohydrate derivative binding (GO:0097367)	2.03	3	HRAS, KRAS, NRAS
organic cyclic compound binding (GO:0097159)	1.05	3	HRAS, KRAS, NRAS
nucleotide binding (GO:0000166)	1.96	3	HRAS, KRAS, NRAS
small molecule binding (GO:0036094)	1.89	3	HRAS, KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561)	3.73	3	HRAS, KRAS, NRAS
purine ribonucleoside binding (GO:0032550)	2.22	3	HRAS, KRAS, NRAS
ribonucleotide binding (GO:0032553)	2.19	3	HRAS, KRAS, NRAS
binding (GO:0005488)	0.18	3	HRAS, KRAS, NRAS
purine nucleoside binding (GO:0001883)	2.22	3	HRAS, KRAS, NRAS
ribonucleoside binding (GO:0032549)	2.22	3	HRAS, KRAS, NRAS
purine ribonucleotide binding (GO:0032555)	2.2	3	HRAS, KRAS, NRAS
purine nucleotide binding (GO:0017076)	2.19	3	HRAS, KRAS, NRAS
GTP binding (GO:0005525)	3.78	3	HRAS, KRAS, NRAS
heterocyclic compound binding (GO:1901363)	1.06	3	HRAS, KRAS, NRAS
nucleoside phosphate binding (GO:1901265)	1.96	3	HRAS, KRAS, NRAS
nucleoside binding (GO:0001882)	2.21	3	HRAS, KRAS, NRAS
hydrolase activity (GO:0016787)	1.9	2	HRAS, KRAS
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	HRAS, KRAS
catalytic activity (GO:0003824)	1.05	2	HRAS, KRAS
GTPase activity (GO:0003924)	4.31	2	HRAS, KRAS
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	HRAS, KRAS
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	HRAS, KRAS
pyrophosphatase activity (GO:0016462)	3.04	2	HRAS, KRAS
macromolecular complex binding (GO:0044877)	2.61	2	KRAS, NRAS
protein complex binding (GO:0032403)	3.09	2	KRAS, NRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
calcium-dependent protein binding (GO:0048306)	NEW	5.68	0.038	HRAS, KRAS
purine ribonucleoside triphosphate binding (GO:0035639)	-	2.22	0.043	HRAS, KRAS, NRAS
NAD+ kinase activity (GO:0003951)	NEW	9.05	0.003	HRAS, KRAS
acetylglucosaminyltransferase activity (GO:0008375)	NEW	5.85	0.014	HRAS, KRAS
purine nucleoside binding (GO:0001883)	-	2.22	0.043	HRAS, KRAS, NRAS
nucleoside binding (GO:0001882)	-	2.21	0.044	HRAS, KRAS, NRAS
SH3/SH2 adaptor activity (GO:0005070)	NEW	5.79	0.028	KRAS, NRAS
guanyl nucleotide binding (GO:0019001)	-	3.73	0.05	HRAS, KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561)	-	3.73	0.0	HRAS, KRAS, NRAS
ribonucleoside binding (GO:0032549)	-	2.22	0.044	HRAS, KRAS, NRAS
purine nucleotide binding (GO:0017076)	-	2.19	0.047	HRAS, KRAS, NRAS
phosphatidylserine binding (GO:0001786)	NEW	6.24	0.006	HRAS, KRAS
GTP binding (GO:0005525)	-	3.78	0.0	HRAS, KRAS, NRAS
NF-kappaB binding (GO:0051059)	NEW	6.34	0.004	HRAS, KRAS
binding, bridging (GO:0060090)	NEW	4.57	0.003	HRAS, KRAS, NRAS
protein binding, bridging (GO:0030674)	NEW	4.68	0.002	HRAS, KRAS, NRAS
diacylglycerol kinase activity (GO:0004143)	NEW	7.34	0.003	HRAS, KRAS
signaling adaptor activity (GO:0035591)	NEW	5.43	0.045	KRAS, NRAS
GDP binding (GO:0019003)	NEW	5.81	0.019	HRAS, KRAS
purine ribonucleotide binding (GO:0032555)	-	2.2	0.045	HRAS, KRAS, NRAS
purine ribonucleoside binding (GO:0032550)	-	2.22	0.043	HRAS, KRAS, NRAS
ribonucleotide binding (GO:0032553)	-	2.19	0.046	HRAS, KRAS, NRAS

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
phosphorylation (GO:0016310)	2.63	3	HRAS, KRAS, NRAS
positive regulation of response to stimulus (GO:0048584)	2.18	3	HRAS, KRAS, NRAS
regulation of response to stimulus (GO:0048583)	1.54	3	HRAS, KRAS, NRAS
axon guidance (GO:0007411)	4.44	3	HRAS, KRAS, NRAS
movement of cell or subcellular component (GO:0006928)	2.61	3	HRAS, KRAS, NRAS
positive regulation of defense response (GO:0031349)	3.83	3	HRAS, KRAS, NRAS
leukocyte migration (GO:0050900)	4.19	3	HRAS, KRAS, NRAS
signal transduction (GO:0007165)	1.28	3	HRAS, KRAS, NRAS
cell surface receptor signaling pathway (GO:0007166)	2.09	3	HRAS, KRAS, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	HRAS, KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	HRAS, KRAS, NRAS
intracellular signal transduction (GO:0035556)	2.39	3	HRAS, KRAS, NRAS
regulation of biological process (GO:0050789)	0.45	3	HRAS, KRAS, NRAS
regulation of defense response (GO:0031347)	3.11	3	HRAS, KRAS, NRAS
cellular protein metabolic process (GO:0044267)	1.63	3	HRAS, KRAS, NRAS
single-organism metabolic process (GO:0044710)	1.63	3	HRAS, KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264)	3.85	3	HRAS, KRAS, NRAS
immune response-regulating signaling pathway (GO:0002764)	3.72	3	HRAS, KRAS, NRAS
cellular macromolecule metabolic process (GO:0044260)	0.93	3	HRAS, KRAS, NRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	3	HRAS, KRAS, NRAS
MAPK cascade (GO:0000165)	3.91	3	HRAS, KRAS, NRAS
Ras protein signal transduction (GO:0007265)	4.76	3	HRAS, KRAS, NRAS
organic substance metabolic process (GO:0071704)	0.63	3	HRAS, KRAS, NRAS
positive regulation of immune system process (GO:0002684)	2.96	3	HRAS, KRAS, NRAS
regulation of immune system process (GO:0002682)	2.5	3	HRAS, KRAS, NRAS
single-organism process (GO:0044699)	0.48	3	HRAS, KRAS, NRAS
positive regulation of biological process (GO:0048518)	1.2	3	HRAS, KRAS, NRAS
biological regulation (GO:0065007)	0.39	3	HRAS, KRAS, NRAS
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	HRAS, KRAS, NRAS
cell migration (GO:0016477)	3.12	3	HRAS, KRAS, NRAS
innate immune response activating cell surface receptor signaling pathway (GO:0002220)	5.07	3	HRAS, KRAS, NRAS
stimulatory C-type lectin receptor signaling pathway (GO:0002223)	5.09	3	HRAS, KRAS, NRAS
protein phosphorylation (GO:0006468)	2.89	3	HRAS, KRAS, NRAS
cellular process (GO:0009987)	0.26	3	HRAS, KRAS, NRAS
positive regulation of innate immune response (GO:0045089)	4.22	3	HRAS, KRAS, NRAS
regulation of innate immune response (GO:0045088)	3.86	3	HRAS, KRAS, NRAS
regulation of immune response (GO:0050776)	2.98	3	HRAS, KRAS, NRAS
cellular protein modification process (GO:0006464)	1.79	3	HRAS, KRAS, NRAS
regulation of cellular process (GO:0050794)	0.5	3	HRAS, KRAS, NRAS
macromolecule modification (GO:0043412)	1.73	3	HRAS, KRAS, NRAS
immune response-activating signal transduction (GO:0002757)	3.8	3	HRAS, KRAS, NRAS
single-organism cellular process (GO:0044763)	0.65	3	HRAS, KRAS, NRAS
metabolic process (GO:0008152)	0.58	3	HRAS, KRAS, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095)	4.84	3	HRAS, KRAS, NRAS
ERBB2 signaling pathway (GO:0038128)	6.09	3	HRAS, KRAS, NRAS
neuron projection guidance (GO:0097485)	4.43	3	HRAS, KRAS, NRAS
locomotion (GO:0040011)	2.91	3	HRAS, KRAS, NRAS
primary metabolic process (GO:0044238)	0.69	3	HRAS, KRAS, NRAS
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	3	HRAS, KRAS, NRAS
Fc receptor signaling pathway (GO:0038093)	4.45	3	HRAS, KRAS, NRAS
cell motility (GO:0048870)	3.02	3	HRAS, KRAS, NRAS
protein metabolic process (GO:0019538)	1.45	3	HRAS, KRAS, NRAS
regulation of response to stress (GO:0080134)	2.53	3	HRAS, KRAS, NRAS
innate immune response-activating signal transduction (GO:0002758)	4.45	3	HRAS, KRAS, NRAS
positive regulation of immune response (GO:0050778)	3.4	3	HRAS, KRAS, NRAS
cellular metabolic process (GO:0044237)	0.69	3	HRAS, KRAS, NRAS
macromolecule metabolic process (GO:0043170)	0.83	3	HRAS, KRAS, NRAS
immune system process (GO:0002376)	2.29	3	HRAS, KRAS, NRAS
activation of innate immune response (GO:0002218)	4.41	3	HRAS, KRAS, NRAS
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	HRAS, KRAS, NRAS
protein modification process (GO:0036211)	1.79	3	HRAS, KRAS, NRAS
activation of immune response (GO:0002253)	3.67	3	HRAS, KRAS, NRAS
phosphorus metabolic process (GO:0006793)	2.15	3	HRAS, KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	3	HRAS, KRAS, NRAS
ERBB signaling pathway (GO:0038127)	5.36	3	HRAS, KRAS, NRAS
regulation of phosphate metabolic process (GO:0019220)	2.35	2	HRAS, KRAS
regulation of primary metabolic process (GO:0080090)	1.08	2	HRAS, KRAS
regulation of metabolic process (GO:0019222)	1.02	2	HRAS, KRAS
behavior (GO:0007610)	3.47	2	HRAS, KRAS
regulation of neuron apoptotic process (GO:0043523)	4.47	2	HRAS, KRAS
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	HRAS, KRAS
cellular component organization or biogenesis (GO:0071840)	1.22	2	HRAS, KRAS
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	2	HRAS, KRAS
regulation of signal transduction (GO:0009966)	1.84	2	HRAS, KRAS
cellular developmental process (GO:0048869)	1.82	2	HRAS, KRAS
positive regulation of molecular function (GO:0044093)	2.23	2	HRAS, KRAS
negative regulation of biological process (GO:0048519)	1.33	2	HRAS, KRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057)	6.04	2	HRAS, KRAS
regulation of small GTPase mediated signal transduction (GO:0051056)	4.08	2	HRAS, KRAS
social behavior (GO:0035176)	5.9	2	HRAS, KRAS
negative regulation of cell death (GO:0060548)	2.95	2	HRAS, KRAS
regulation of protein kinase activity (GO:0045859)	3.15	2	HRAS, KRAS
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	HRAS, KRAS
intraspecies interaction between organisms (GO:0051703)	5.9	2	HRAS, KRAS
multi-organism behavior (GO:0051705)	5.6	2	HRAS, KRAS
multi-organism process (GO:0051704)	2.65	2	HRAS, KRAS
regulation of phosphorylation (GO:0042325)	2.5	2	HRAS, KRAS
positive regulation of phosphorylation (GO:0042327)	2.9	2	HRAS, KRAS
positive regulation of metabolic process (GO:0009893)	1.74	2	HRAS, KRAS
negative regulation of neuron death (GO:1901215)	4.57	2	HRAS, KRAS
positive regulation of kinase activity (GO:0033674)	3.54	2	HRAS, KRAS
regulation of synaptic plasticity (GO:0048167)	4.78	2	HRAS, KRAS
positive regulation of gene expression (GO:0010628)	2.35	2	HRAS, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	HRAS, KRAS
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	HRAS, KRAS
regulation of apoptotic process (GO:0042981)	2.5	2	HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168)	5.84	2	HRAS, KRAS
regulation of cell communication (GO:0010646)	1.73	2	HRAS, KRAS
positive regulation of transferase activity (GO:0051347)	3.31	2	HRAS, KRAS
regulation of kinase activity (GO:0043549)	3.07	2	HRAS, KRAS
cellular component organization (GO:0016043)	1.24	2	HRAS, KRAS
regulation of molecular function (GO:0065009)	1.78	2	HRAS, KRAS
regulation of biological quality (GO:0065008)	1.68	2	HRAS, KRAS
regulation of catalytic activity (GO:0050790)	1.97	2	HRAS, KRAS
regulation of biosynthetic process (GO:0009889)	1.37	2	HRAS, KRAS
positive regulation of MAPK cascade (GO:0043410)	3.57	2	HRAS, KRAS
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	HRAS, KRAS
regulation of neuron death (GO:1901214)	4.19	2	HRAS, KRAS
establishment of localization (GO:0051234)	1.48	2	HRAS, NRAS
single-organism developmental process (GO:0044767)	1.49	2	HRAS, KRAS
response to stimulus (GO:0050896)	1.22	2	HRAS, KRAS
positive regulation of protein modification process (GO:0031401)	2.7	2	HRAS, KRAS
regulation of transferase activity (GO:0051338)	2.88	2	HRAS, KRAS
developmental process (GO:0032502)	1.36	2	HRAS, KRAS
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	HRAS, KRAS
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	HRAS, KRAS
positive regulation of signal transduction (GO:0009967)	2.5	2	HRAS, KRAS
regulation of synapse structure or activity (GO:0050803)	4.77	2	HRAS, KRAS
regulation of Ras protein signal transduction (GO:0046578)	4.49	2	HRAS, KRAS
positive regulation of Ras protein signal transduction (GO:0046579)	6.2	2	HRAS, KRAS
modulation of synaptic transmission (GO:0050804)	4.09	2	HRAS, KRAS
positive regulation of signaling (GO:0023056)	2.41	2	HRAS, KRAS
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	HRAS, KRAS
regulation of MAP kinase activity (GO:0043405)	3.95	2	HRAS, KRAS
regulation of signaling (GO:0023051)	1.72	2	HRAS, KRAS
positive regulation of cell communication (GO:0010647)	2.41	2	HRAS, KRAS
anatomical structure morphogenesis (GO:0009653)	2.53	2	HRAS, KRAS
positive regulation of catalytic activity (GO:0043085)	2.4	2	HRAS, KRAS
regulation of MAPK cascade (GO:0043408)	3.22	2	HRAS, KRAS
regulation of intracellular signal transduction (GO:1902531)	2.31	2	HRAS, KRAS
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	HRAS, KRAS
regulation of protein metabolic process (GO:0051246)	1.93	2	HRAS, KRAS
positive regulation of protein metabolic process (GO:0051247)	2.43	2	HRAS, KRAS
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	HRAS, KRAS
regulation of protein modification process (GO:0031399)	2.32	2	HRAS, KRAS
positive regulation of cell proliferation (GO:0008284)	3.01	2	HRAS, KRAS
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	HRAS, KRAS
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	HRAS, KRAS
regulation of RNA metabolic process (GO:0051252)	1.52	2	HRAS, KRAS
positive regulation of protein kinase activity (GO:0045860)	3.61	2	HRAS, KRAS
regulation of cell proliferation (GO:0042127)	2.41	2	HRAS, KRAS
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	HRAS, KRAS
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	HRAS, KRAS
regulation of cellular metabolic process (GO:0031323)	1.07	2	HRAS, KRAS
regulation of cell death (GO:0010941)	2.43	2	HRAS, KRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169)	6.55	2	HRAS, KRAS
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	HRAS, KRAS
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	HRAS, KRAS
regulation of programmed cell death (GO:0043067)	2.49	2	HRAS, KRAS
negative regulation of apoptotic process (GO:0043066)	3.04	2	HRAS, KRAS
negative regulation of programmed cell death (GO:0043069)	3.02	2	HRAS, KRAS
regulation of gene expression (GO:0010468)	1.37	2	HRAS, KRAS
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	HRAS, KRAS
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	HRAS, KRAS
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	HRAS, KRAS
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	HRAS, KRAS
localization (GO:0051179)	1.4	2	HRAS, NRAS
regulation of protein phosphorylation (GO:0001932)	2.57	2	HRAS, KRAS
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	HRAS, KRAS
negative regulation of cellular process (GO:0048523)	1.41	2	HRAS, KRAS
positive regulation of cellular process (GO:0048522)	1.3	2	HRAS, KRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hemostasis (GO:0007599)	NEW	4.5	0.007	HRAS, KRAS, NRAS
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.023	HRAS, KRAS, NRAS
blood coagulation (GO:0007596)	NEW	4.52	0.007	HRAS, KRAS, NRAS
learning (GO:0007612)	NEW	4.85	0.011	HRAS, KRAS, NRAS
activation of protein kinase activity (GO:0032147)	NEW	4.08	0.001	HRAS, KRAS, NRAS
behavior (GO:0007610)	-	3.47	0.008	HRAS, KRAS, NRAS
learning or memory (GO:0007611)	NEW	4.33	0.001	HRAS, KRAS, NRAS
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.019	HRAS, KRAS, NRAS
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.017	HRAS, KRAS, NRAS
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.0	HRAS, KRAS, NRAS
negative regulation of neuron apoptotic process (GO:0043524)	-	4.82	0.013	HRAS, KRAS, NRAS
GTP metabolic process (GO:0046039)	NEW	6.59	0.001	HRAS, KRAS, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167)	-	3.24	0.029	HRAS, KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	-	3.54	0.012	HRAS, KRAS, NRAS
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.015	HRAS, KRAS, NRAS
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.001	HRAS, KRAS, NRAS
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.027	HRAS, KRAS, NRAS
MAPK cascade (GO:0000165)	-	3.91	0.0	HRAS, KRAS, NRAS
response to growth factor (GO:0070848)	NEW	4.14	0.013	HRAS, KRAS, NRAS
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.02	HRAS, KRAS, NRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057)	-	6.04	0.0	HRAS, KRAS, NRAS
regulation of small GTPase mediated signal transduction (GO:0051056)	-	4.08	0.001	HRAS, KRAS, NRAS
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.02	HRAS, KRAS, NRAS
neurotrophin signaling pathway (GO:0038179)	NEW	6.55	0.001	HRAS, KRAS, NRAS
social behavior (GO:0035176)	-	5.9	0.006	HRAS, KRAS
negative regulation of cell death (GO:0060548)	-	2.95	0.027	HRAS, KRAS, NRAS
regulation of protein kinase activity (GO:0045859)	-	3.15	0.023	HRAS, KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173)	-	5.72	0.0	HRAS, KRAS, NRAS
intraspecies interaction between organisms (GO:0051703)	-	5.9	0.006	HRAS, KRAS
response to peptide hormone (GO:0043434)	NEW	4.06	0.003	HRAS, KRAS, NRAS
neuron projection guidance (GO:0097485)	-	4.43	0.003	HRAS, KRAS, NRAS
multi-organism behavior (GO:0051705)	-	5.6	0.023	HRAS, KRAS
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.016	HRAS, KRAS, NRAS
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.031	HRAS, KRAS, NRAS
cell motility (GO:0048870)	-	3.02	0.027	HRAS, KRAS, NRAS
single-organism behavior (GO:0044708)	NEW	3.79	0.003	HRAS, KRAS, NRAS
response to organonitrogen compound (GO:0010243)	NEW	3.2	0.021	HRAS, KRAS, NRAS
regulation of synaptic transmission, GABAergic (GO:0032228)	NEW	6.36	0.0	HRAS, KRAS, NRAS
purine nucleotide metabolic process (GO:0006163)	NEW	4.09	0.034	HRAS, KRAS, NRAS
response to hormone (GO:0009725)	NEW	3.33	0.032	HRAS, KRAS, NRAS
response to light stimulus (GO:0009416)	NEW	4.08	0.002	HRAS, KRAS, NRAS
muscle cell differentiation (GO:0042692)	NEW	5.09	0.011	HRAS, KRAS, NRAS
visual behavior (GO:0007632)	NEW	5.82	0.001	HRAS, KRAS, NRAS
positive regulation of kinase activity (GO:0033674)	-	3.54	0.007	HRAS, KRAS, NRAS
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.022	HRAS, KRAS, NRAS
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.015	HRAS, KRAS, NRAS
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.02	HRAS, KRAS, NRAS
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.014	HRAS, KRAS, NRAS
positive regulation of cell proliferation (GO:0008284)	-	3.01	0.03	HRAS, KRAS, NRAS
regulation of synaptic plasticity (GO:0048167)	-	4.78	0.012	HRAS, KRAS, NRAS
morphogenesis of a branching structure (GO:0001763)	NEW	4.71	0.0	HRAS, KRAS, NRAS
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.017	HRAS, KRAS, NRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169)	-	6.55	0.0	HRAS, KRAS, NRAS
regulation of neuronal synaptic plasticity (GO:0048168)	-	5.84	0.0	HRAS, KRAS, NRAS
positive regulation of transferase activity (GO:0051347)	-	3.31	0.012	HRAS, KRAS, NRAS
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.044	HRAS, KRAS, NRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	-	3.96	0.006	HRAS, KRAS, NRAS
regulation of kinase activity (GO:0043549)	-	3.07	0.027	HRAS, KRAS, NRAS
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.023	HRAS, KRAS, NRAS
ribonucleotide metabolic process (GO:0009259)	NEW	4.11	0.033	HRAS, KRAS, NRAS
guanosine-containing compound catabolic process (GO:1901069)	NEW	8.63	0.001	HRAS, KRAS, NRAS
guanosine-containing compound metabolic process (GO:1901068)	NEW	5.9	0.001	HRAS, KRAS, NRAS
cell migration (GO:0016477)	-	3.12	0.02	HRAS, KRAS, NRAS
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.014	HRAS, KRAS, NRAS
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.016	HRAS, KRAS, NRAS
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.031	HRAS, KRAS, NRAS
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.016	HRAS, KRAS, NRAS
associative learning (GO:0008306)	NEW	5.44	0.0	HRAS, KRAS, NRAS
neurotrophin TRK receptor signaling pathway (GO:0048011)	NEW	6.96	0.001	HRAS, KRAS, NRAS
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.022	HRAS, KRAS, NRAS
regulation of neuron death (GO:1901214)	-	4.19	0.001	HRAS, KRAS, NRAS
negative regulation of neuron death (GO:1901215)	-	4.57	0.0	HRAS, KRAS, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095)	-	4.84	0.002	HRAS, KRAS, NRAS
Fc receptor signaling pathway (GO:0038093)	-	4.45	0.003	HRAS, KRAS, NRAS
response to nitrogen compound (GO:1901698)	NEW	3.12	0.027	HRAS, KRAS, NRAS
cellular response to nitrogen compound (GO:1901699)	NEW	3.79	0.006	HRAS, KRAS, NRAS
cognition (GO:0050890)	NEW	4.2	0.001	HRAS, KRAS, NRAS
regulation of transferase activity (GO:0051338)	-	2.88	0.041	HRAS, KRAS, NRAS
coagulation (GO:0050817)	NEW	4.51	0.007	HRAS, KRAS, NRAS
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.019	HRAS, KRAS, NRAS
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.0	HRAS, KRAS, NRAS
response to radiation (GO:0009314)	NEW	3.69	0.006	HRAS, KRAS, NRAS
regulation of Ras protein signal transduction (GO:0046578)	-	4.49	0.0	HRAS, KRAS, NRAS
positive regulation of Ras protein signal transduction (GO:0046579)	-	6.2	0.0	HRAS, KRAS, NRAS
regulation of synaptic transmission (GO:0050804)	-	4.09	0.001	HRAS, KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020)	NEW	7.24	0.0	HRAS, KRAS, NRAS
ERBB signaling pathway (GO:0038127)	-	5.36	0.0	HRAS, KRAS, NRAS
positive regulation of Rac protein signal transduction (GO:0035022)	NEW	8.63	0.0	HRAS, KRAS, NRAS
axon guidance (GO:0007411)	-	4.44	0.003	HRAS, KRAS, NRAS
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.0	HRAS, KRAS, NRAS
visual learning (GO:0008542)	NEW	5.92	0.0	HRAS, KRAS, NRAS
regulation of MAPK cascade (GO:0043408)	-	3.22	0.01	HRAS, KRAS, NRAS
cellular response to peptide hormone stimulus (GO:0071375)	NEW	4.63	0.001	HRAS, KRAS, NRAS
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.044	HRAS, KRAS, NRAS
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.028	HRAS, KRAS, NRAS
epithelial tube branching involved in lung morphogenesis (GO:0060441)	NEW	6.9	0.0	HRAS, KRAS, NRAS
cellular response to endogenous stimulus (GO:0071495)	NEW	3.33	0.044	HRAS, KRAS, NRAS
insulin receptor signaling pathway (GO:0008286)	NEW	5.33	0.009	HRAS, KRAS, NRAS
regulation of body fluid levels (GO:0050878)	NEW	3.76	0.014	HRAS, KRAS, NRAS
neurological system process (GO:0050877)	NEW	2.64	0.027	HRAS, KRAS, NRAS
negative regulation of cell differentiation (GO:0045596)	NEW	3.33	0.01	HRAS, KRAS, NRAS
cellular response to hormone stimulus (GO:0032870)	NEW	3.99	0.007	HRAS, KRAS, NRAS
actin cytoskeleton organization (GO:0030036)	NEW	4.1	0.001	HRAS, KRAS, NRAS
negative regulation of developmental process (GO:0051093)	NEW	3.17	0.02	HRAS, KRAS, NRAS
monocyte chemotaxis (GO:0002548)	NEW	6.04	0.024	HRAS, KRAS
cellular response to growth factor stimulus (GO:0071363)	NEW	4.27	0.012	HRAS, KRAS, NRAS
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.029	HRAS, KRAS, NRAS
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.014	HRAS, KRAS, NRAS
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.006	HRAS, KRAS, NRAS
activation of MAPKK activity (GO:0000186)	NEW	5.74	0.0	HRAS, KRAS, NRAS
positive regulation of protein modification process (GO:0031401)	-	2.7	0.041	HRAS, KRAS, NRAS
striated muscle cell differentiation (GO:0051146)	NEW	5.69	0.0	HRAS, KRAS, NRAS
branching morphogenesis of an epithelial tube (GO:0048754)	NEW	4.93	0.021	HRAS, KRAS, NRAS
leukocyte migration (GO:0050900)	-	4.19	0.001	HRAS, KRAS, NRAS
response to insulin (GO:0032868)	NEW	4.72	0.001	HRAS, KRAS, NRAS
cellular response to insulin stimulus (GO:0032869)	NEW	5.29	0.0	HRAS, KRAS, NRAS
purine-containing compound metabolic process (GO:0072521)	NEW	4.0	0.04	HRAS, KRAS, NRAS
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.018	HRAS, KRAS, NRAS
morphogenesis of an epithelium (GO:0002009)	NEW	4.08	0.002	HRAS, KRAS, NRAS
cellular response to organonitrogen compound (GO:0071417)	NEW	3.87	0.005	HRAS, KRAS, NRAS
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.021	HRAS, KRAS, NRAS
tissue morphogenesis (GO:0048729)	NEW	3.87	0.003	HRAS, KRAS, NRAS
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.015	HRAS, KRAS, NRAS
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.022	HRAS, KRAS, NRAS
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.03	HRAS, KRAS, NRAS
actin filament-based process (GO:0030029)	NEW	3.94	0.002	HRAS, KRAS, NRAS
morphogenesis of a branching epithelium (GO:0061138)	NEW	4.77	0.0	HRAS, KRAS, NRAS
innate immune response (GO:0045087)	NEW	3.55	0.033	HRAS, KRAS, NRAS
nucleoside metabolic process (GO:0009116)	NEW	4.12	0.034	HRAS, KRAS, NRAS
Ras protein signal transduction (GO:0007265)	-	4.76	0.016	HRAS, KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264)	-	3.85	0.007	HRAS, KRAS, NRAS
immune response-regulating signaling pathway (GO:0002764)	-	3.72	0.011	HRAS, KRAS, NRAS
locomotion (GO:0040011)	-	2.91	0.041	HRAS, KRAS, NRAS
cellular response to oxygen-containing compound (GO:1901701)	NEW	3.22	0.024	HRAS, KRAS, NRAS
cytoskeleton organization (GO:0007010)	NEW	3.22	0.017	HRAS, KRAS, NRAS
ribose phosphate metabolic process (GO:0019693)	NEW	4.06	0.034	HRAS, KRAS, NRAS
glycosyl compound metabolic process (GO:1901657)	NEW	4.04	0.036	HRAS, KRAS, NRAS
response to peptide (GO:1901652)	NEW	3.94	0.004	HRAS, KRAS, NRAS
cellular response to peptide (GO:1901653)	NEW	4.52	0.001	HRAS, KRAS, NRAS
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.019	HRAS, KRAS, NRAS
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.017	HRAS, KRAS, NRAS

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	HRAS, KRAS, NRAS
membrane (GO:0016020)	0.68	3	HRAS, KRAS, NRAS
cell part (GO:0044464)	0.11	3	HRAS, KRAS, NRAS
cytoplasmic part (GO:0044444)	0.82	3	HRAS, KRAS, NRAS
intracellular (GO:0005622)	2.37	3	HRAS, KRAS, NRAS
intracellular organelle (GO:0043229)	0.51	3	HRAS, KRAS, NRAS
plasma membrane (GO:0005886)	1.39	3	HRAS, KRAS, NRAS
intracellular part (GO:0044424)	0.28	3	HRAS, KRAS, NRAS
membrane-bounded organelle (GO:0043227)	0.47	3	HRAS, KRAS, NRAS
organelle (GO:0043226)	0.4	3	HRAS, KRAS, NRAS
cytoplasm (GO:0005737)	1.01	2	HRAS, KRAS
Golgi apparatus (GO:0005794)	2.7	2	HRAS, NRAS
organelle membrane (GO:0031090)	1.97	2	HRAS, NRAS
bounding membrane of organelle (GO:0098588)	2.39	2	HRAS, NRAS
Golgi membrane (GO:0000139)	3.28	2	HRAS, NRAS
intracellular organelle part (GO:0044446)	0.81	2	HRAS, NRAS
Golgi apparatus part (GO:0044431)	3.0	2	HRAS, NRAS
cytosol (GO:0005829)	1.68	2	HRAS, KRAS
organelle part (GO:0044422)	0.79	2	HRAS, NRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein kinase complex (GO:1902911)	NEW	5.31	0.035	HRAS, KRAS
Golgi cisterna membrane (GO:0032580)	NEW	5.5	0.048	HRAS, KRAS
endosomal part (GO:0044440)	NEW	3.73	0.034	HRAS, KRAS, NRAS
endosome membrane (GO:0010008)	NEW	3.83	0.03	HRAS, KRAS, NRAS