Disease table of SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME OMIM ID: 163200

Gene-disease associations table

GeneAssociated with SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HRASClinVar, OMIM, HUMSAVARHGNC link11p15.56218040, 137550, 185500, 109800, 163200, 162900
NRASClinVar, OMIMHGNC link1p13.28137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
KRASClinVar, OMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HRASYES3SP1, MAZ, TP530
NRASYES1AR0
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HRASNRASNo7RAP1GDS1, RABGGTB, MLLT4, RAF1, PIK3CG, RGL2, TMEM185A
HRASKRASNo10RALGDS, RASSF5, RGL2, IL24, PIK3CA, BTRC, RAF1, PIK3CG, RAP1GDS1, SHOC2
NRASKRASNo6RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
HRASKRASYesbinding111RASA1, AKT1, RASSF4, TP53, MAP3K2, PIK3CA, EGFR, GAST, NCAM1, YWHAB, SPTAN1, PPARD, PTK2, MAPK14, RET, CALM1, SLC3A2, MAPK13, RPS6KB1, JUN, ETS2, ABL1, SPTBN5, CCR5, TNS4, MAPK3, BTRC, MTOR, FRS2, MAZ, MAP3K3, ARAF, KSR2, IL8, LGALS3, JUND, RASGRP3, SPTBN1, DDX43, TEK, KSR1, CNKSR3, SHC3, RGL4, NPM1, GRB2, RASGRF2, MAP3K19, RALGDS, SPTA1, RASA2, CDX1, SPRY2, UBC, MLLT4, MAP2K2, BMP4, NT5E, SPTBN4, HBEGF, FYN, RGL1, RASSF2, MAPK11, CCND1, SHC2, ERBB3, ETS1, RAF1, SHOC2, KIT, LGALS1, PTPRA, VEGFA, MAPK12, YES1, MGMT, SPTB, MEN1, RASGRP1, RASA3, PIK3CD, MDM4, PTPN11, PIK3CG, IGF2BP1, ANGPT1, ITSN1, MAP2K1, SOS1, EPHA2, ERBB2, MECOM, SHC1, MAPK7, NCL, AKT2, CDX2, SPTBN2, EGF, RASSF7, SRC, BCL2L11, NOTCH1, BCL2, MAPK1, PIK3CB, IRS1, IRS2, BRAF, ERBB4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
HRASNRASYesRAF1-RAS complex, EGF induced2KRAS, RAF1
HRASKRASYesRAF1-RAS complex, EGF induced2NRAS, RAF1
NRASKRASYesRAF1-RAS complex, EGF induced2HRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
HRASKRASNo
HRASNRASmaybe, indirectThey are member of the same protein family.
KRASNRASmaybe, indirectThey are members of the same protein family.
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.63HRAS, KRAS, NRAS
Bladder cancerhsa052197.383HRAS, KRAS, NRAS
Endometrial cancerhsa052136.813HRAS, KRAS, NRAS
Renal cell carcinomahsa052116.63HRAS, KRAS, NRAS
Thyroid cancerhsa052167.483HRAS, KRAS, NRAS
Melanomahsa052186.563HRAS, KRAS, NRAS
Gliomahsa052146.663HRAS, KRAS, NRAS
Prostate cancerhsa052156.113HRAS, KRAS, NRAS
Tight junctionhsa045305.533HRAS, KRAS, NRAS
Long-term potentiationhsa047206.643HRAS, KRAS, NRAS
Neurotrophin signaling pathwayhsa047225.783HRAS, KRAS, NRAS
Cholinergic synapsehsa047255.883HRAS, KRAS, NRAS
Choline metabolism in cancerhsa052316.093HRAS, KRAS, NRAS
FoxO signaling pathwayhsa040685.633HRAS, KRAS, NRAS
Serotonergic synapsehsa047265.843HRAS, KRAS, NRAS
Chemokine signaling pathwayhsa040625.193HRAS, KRAS, NRAS
Oxytocin signaling pathwayhsa049215.43HRAS, KRAS, NRAS
Rap1 signaling pathwayhsa040154.973HRAS, KRAS, NRAS
Natural killer cell mediated cytotoxicityhsa046505.533HRAS, KRAS, NRAS
HTLV-I infectionhsa051664.593HRAS, KRAS, NRAS
PI3K-Akt signaling pathwayhsa041514.213HRAS, KRAS, NRAS
Hepatitis Chsa051605.683HRAS, KRAS, NRAS
Hepatitis Bhsa051615.523HRAS, KRAS, NRAS
Chronic myeloid leukemiahsa052206.483HRAS, KRAS, NRAS
Gap junctionhsa045406.243HRAS, KRAS, NRAS
VEGF signaling pathwayhsa043706.773HRAS, KRAS, NRAS
Proteoglycans in cancerhsa052055.023HRAS, KRAS, NRAS
MicroRNAs in cancerhsa052065.383HRAS, KRAS, NRAS
Pathways in cancerhsa052003.983HRAS, KRAS, NRAS
Viral carcinogenesishsa052035.083HRAS, KRAS, NRAS
GnRH signaling pathwayhsa049126.183HRAS, KRAS, NRAS
Insulin signaling pathwayhsa049105.553HRAS, KRAS, NRAS
Ras signaling pathwayhsa040144.93HRAS, KRAS, NRAS
Melanogenesishsa049165.973HRAS, KRAS, NRAS
ErbB signaling pathwayhsa040126.153HRAS, KRAS, NRAS
Acute myeloid leukemiahsa052216.743HRAS, KRAS, NRAS
Estrogen signaling pathwayhsa049156.113HRAS, KRAS, NRAS
Thyroid hormone signaling pathwayhsa049195.823HRAS, KRAS, NRAS
Long-term depressionhsa047306.743HRAS, KRAS, NRAS
Regulation of actin cytoskeletonhsa048104.93HRAS, KRAS, NRAS
T cell receptor signaling pathwayhsa046606.013HRAS, KRAS, NRAS
Non-small cell lung cancerhsa052236.883HRAS, KRAS, NRAS
MAPK signaling pathwayhsa040104.633HRAS, KRAS, NRAS
B cell receptor signaling pathwayhsa046626.523HRAS, KRAS, NRAS
Alcoholismhsa050345.593HRAS, KRAS, NRAS
Axon guidancehsa043605.633HRAS, KRAS, NRAS
Central carbon metabolism in cancerhsa052306.73HRAS, KRAS, NRAS
Fc epsilon RI signaling pathwayhsa046646.63HRAS, KRAS, NRAS
Prolactin signaling pathwayhsa049176.63HRAS, KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.006HRAS, KRAS, NRAS
Bladder cancer (hsa05219) -7.380.0HRAS, KRAS, NRAS
T cell receptor signaling pathway (hsa04660) -6.010.002HRAS, KRAS, NRAS
Endometrial cancer (hsa05213) -6.810.0HRAS, KRAS, NRAS
Renal cell carcinoma (hsa05211) -6.60.0HRAS, KRAS, NRAS
Thyroid cancer (hsa05216) -7.480.0HRAS, KRAS, NRAS
Melanoma (hsa05218) -6.560.0HRAS, KRAS, NRAS
Glioma (hsa05214) -6.660.0HRAS, KRAS, NRAS
Prostate cancer (hsa05215) -6.110.001HRAS, KRAS, NRAS
Serotonergic synapse (hsa04726) -5.840.003HRAS, KRAS, NRAS
Nervous systemNEW3.770.029HRAS, KRAS, NRAS
Neurotrophin signaling pathway (hsa04722) -5.780.003HRAS, KRAS, NRAS
Central carbon metabolism in cancer (hsa05230) -6.70.0HRAS, KRAS, NRAS
Choline metabolism in cancer (hsa05231) -6.090.002HRAS, KRAS, NRAS
FoxO signaling pathway (hsa04068) -5.630.007HRAS, KRAS, NRAS
Cellular communityNEW3.570.044HRAS, KRAS, NRAS
Chemokine signaling pathway (hsa04062) -5.190.001HRAS, KRAS, NRAS
Oxytocin signaling pathway (hsa04921) -5.40.001HRAS, KRAS, NRAS
DevelopmentNEW4.580.005HRAS, KRAS, NRAS
Substance dependenceNEW4.770.004HRAS, KRAS, NRAS
Cholinergic synapse (hsa04725) -5.880.002HRAS, KRAS, NRAS
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.001HRAS, KRAS, NRAS
Circulatory systemNEW4.630.038HRAS, KRAS, NRAS
Regulation of actin cytoskeleton (hsa04810) -4.90.022HRAS, KRAS, NRAS
Hepatitis C (hsa05160) -5.680.001HRAS, KRAS, NRAS
Hepatitis B (hsa05161) -5.520.001HRAS, KRAS, NRAS
Chronic myeloid leukemia (hsa05220) -6.480.0HRAS, KRAS, NRAS
Cancers: Specific typesNEW4.10.015HRAS, KRAS, NRAS
Gap junction (hsa04540) -6.240.001HRAS, KRAS, NRAS
VEGF signaling pathway (hsa04370) -6.770.0HRAS, KRAS, NRAS
Proteoglycans in cancer (hsa05205) -5.020.002HRAS, KRAS, NRAS
Estrogen signaling pathway (hsa04915) -6.110.001HRAS, KRAS, NRAS
MicroRNAs in cancer (hsa05206) -5.380.007HRAS, KRAS, NRAS
Pathways in cancer (hsa05200) -3.980.019HRAS, KRAS, NRAS
Rap1 signaling pathway (hsa04015) -4.970.027HRAS, KRAS, NRAS
GnRH signaling pathway (hsa04912) -6.180.0HRAS, KRAS, NRAS
B cell receptor signaling pathway (hsa04662) -6.520.0HRAS, KRAS, NRAS
Ras signaling pathway (hsa04014) -4.90.003HRAS, KRAS, NRAS
Melanogenesis (hsa04916) -5.970.002HRAS, KRAS, NRAS
ErbB signaling pathway (hsa04012) -6.150.0HRAS, KRAS, NRAS
Acute myeloid leukemia (hsa05221) -6.740.0HRAS, KRAS, NRAS
MAPK signaling pathway (hsa04010) -4.630.039HRAS, KRAS, NRAS
Viral carcinogenesis (hsa05203) -5.080.002HRAS, KRAS, NRAS
Thyroid hormone signaling pathway (hsa04919) -5.820.0HRAS, KRAS, NRAS
Cell motilityNEW4.90.022HRAS, KRAS, NRAS
HTLV-I infection (hsa05166) -4.590.005HRAS, KRAS, NRAS
Long-term depression (hsa04730) -6.740.0HRAS, KRAS, NRAS
PI3K-Akt signaling pathway (hsa04151) -4.210.012HRAS, KRAS, NRAS
Tight junction (hsa04530) -5.530.001HRAS, KRAS, NRAS
Long-term potentiation (hsa04720) -6.640.0HRAS, KRAS, NRAS
Non-small cell lung cancer (hsa05223) -6.880.0HRAS, KRAS, NRAS
Insulin signaling pathway (hsa04910) -5.550.001HRAS, KRAS, NRAS
Glycosphingolipid biosynthesis - lacto and neolacto series (hsa00601) NEW7.860.018HRAS, KRAS
Alcoholism (hsa05034) -5.590.001HRAS, KRAS, NRAS
Axon guidance (hsa04360) -5.630.001HRAS, KRAS, NRAS
Fc epsilon RI signaling pathway (hsa04664) -6.60.0HRAS, KRAS, NRAS
Prolactin signaling pathway (hsa04917) -6.60.0HRAS, KRAS, NRAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Interleukin-2 signalingR-HSA-4519275.053HRAS, KRAS, NRAS
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.623HRAS, KRAS, NRAS
Developmental BiologyR-HSA-12667383.483HRAS, KRAS, NRAS
Signaling by VEGFR-HSA-1941384.663HRAS, KRAS, NRAS
FCERI mediated MAPK activationR-HSA-28717964.323HRAS, KRAS, NRAS
IRS-mediated signallingR-HSA-1123994.873HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.733HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.083HRAS, KRAS, NRAS
Signaling by EGFRvIII in CancerR-HSA-56378129.083HRAS, KRAS, NRAS
VEGFA-VEGFR2 PathwayR-HSA-44200974.73HRAS, KRAS, NRAS
Signaling by FGFR1 in diseaseR-HSA-56553027.813HRAS, KRAS, NRAS
Downstream signaling of activated FGFR3R-HSA-56547084.713HRAS, KRAS, NRAS
SOS-mediated signallingR-HSA-1124125.153HRAS, KRAS, NRAS
Tie2 SignalingR-HSA-2109938.813HRAS, KRAS, NRAS
Downstream signaling of activated FGFR4R-HSA-56547164.713HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR4R-HSA-56547198.463HRAS, KRAS, NRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.073HRAS, KRAS, NRAS
Immune SystemR-HSA-1682562.373HRAS, KRAS, NRAS
Frs2-mediated activationR-HSA-1709685.123HRAS, KRAS, NRAS
Downstream signal transductionR-HSA-1867634.653HRAS, KRAS, NRAS
RAF activationR-HSA-56730008.343HRAS, KRAS, NRAS
RAF/MAP kinase cascadeR-HSA-56730015.153HRAS, KRAS, NRAS
Signalling to p38 via RIT and RINR-HSA-1877065.123HRAS, KRAS, NRAS
FRS-mediated FGFR2 signalingR-HSA-56547005.143HRAS, KRAS, NRAS
FRS-mediated FGFR4 signalingR-HSA-56547125.143HRAS, KRAS, NRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.143HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR3R-HSA-56547048.813HRAS, KRAS, NRAS
Activation of RAS in B cellsR-HSA-116909210.663HRAS, KRAS, NRAS
Signaling by EGFR in CancerR-HSA-16437138.733HRAS, KRAS, NRAS
Signaling by FGFR in diseaseR-HSA-12260997.493HRAS, KRAS, NRAS
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.033HRAS, KRAS, NRAS
Interleukin receptor SHC signalingR-HSA-9125265.093HRAS, KRAS, NRAS
Innate Immune SystemR-HSA-1682493.173HRAS, KRAS, NRAS
Signaling by ERBB2R-HSA-12279864.663HRAS, KRAS, NRAS
SHC-related events triggered by IGF1RR-HSA-24289339.813HRAS, KRAS, NRAS
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.513HRAS, KRAS, NRAS
Prolonged ERK activation eventsR-HSA-1698935.113HRAS, KRAS, NRAS
Signaling by FGFR2R-HSA-56547384.683HRAS, KRAS, NRAS
GRB2 events in EGFR signalingR-HSA-1798125.153HRAS, KRAS, NRAS
Signaling by FGFR1R-HSA-56547364.693HRAS, KRAS, NRAS
DAP12 interactionsR-HSA-21721274.563HRAS, KRAS, NRAS
EGFR Transactivation by GastrinR-HSA-21793929.813HRAS, KRAS, NRAS
Axon guidanceR-HSA-4224753.933HRAS, KRAS, NRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.233HRAS, KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263HRAS, KRAS, NRAS
Signaling by FGFR3 in diseaseR-HSA-56553328.523HRAS, KRAS, NRAS
Signaling by LeptinR-HSA-25865525.13HRAS, KRAS, NRAS
MAP2K and MAPK activationR-HSA-56741357.663HRAS, KRAS, NRAS
IGF1R signaling cascadeR-HSA-24289244.853HRAS, KRAS, NRAS
IRS-related events triggered by IGF1RR-HSA-24289284.853HRAS, KRAS, NRAS
Signaling by Insulin receptorR-HSA-747524.733HRAS, KRAS, NRAS
DiseaseR-HSA-16436853.333HRAS, KRAS, NRAS
Insulin receptor signalling cascadeR-HSA-747514.853HRAS, KRAS, NRAS
Downstream signaling of activated FGFR1R-HSA-56546874.713HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR1R-HSA-56546888.593HRAS, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593HRAS, KRAS, NRAS
C-type lectin receptors (CLRs)R-HSA-56214816.063HRAS, KRAS, NRAS
Diseases of signal transductionR-HSA-56632024.893HRAS, KRAS, NRAS
GRB2 events in ERBB2 signalingR-HSA-19636405.153HRAS, KRAS, NRAS
Signalling to RASR-HSA-1670445.083HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR2R-HSA-56546998.283HRAS, KRAS, NRAS
Downstream signaling of activated FGFR2R-HSA-56546964.713HRAS, KRAS, NRAS
SHC1 events in EGFR signalingR-HSA-1803365.153HRAS, KRAS, NRAS
FRS-mediated FGFR1 signalingR-HSA-56546935.143HRAS, KRAS, NRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.153HRAS, KRAS, NRAS
Signaling by EGFRR-HSA-1779294.593HRAS, KRAS, NRAS
ARMS-mediated activationR-HSA-1709845.123HRAS, KRAS, NRAS
CD209 (DC-SIGN) signalingR-HSA-56215758.593HRAS, KRAS, NRAS
SHC1 events in ERBB4 signalingR-HSA-12503475.153HRAS, KRAS, NRAS
Signaling by PDGFR-HSA-1867974.533HRAS, KRAS, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.853HRAS, KRAS, NRAS
p38MAPK eventsR-HSA-1710079.283HRAS, KRAS, NRAS
Signaling by InterleukinsR-HSA-4491474.713HRAS, KRAS, NRAS
Cell surface interactions at the vascular wallR-HSA-2027336.323HRAS, KRAS, NRAS
Cytokine Signaling in Immune systemR-HSA-12802153.743HRAS, KRAS, NRAS
Signaling by ERBB4R-HSA-12363944.73HRAS, KRAS, NRAS
MAPK1/MAPK3 signalingR-HSA-56849965.113HRAS, KRAS, NRAS
Adaptive Immune SystemR-HSA-12802183.193HRAS, KRAS, NRAS
MAPK family signaling cascadesR-HSA-56830574.893HRAS, KRAS, NRAS
Signalling by NGFR-HSA-1665204.233HRAS, KRAS, NRAS
Signaling by FGFR4R-HSA-56547434.693HRAS, KRAS, NRAS
Signaling by FGFR3R-HSA-56547414.693HRAS, KRAS, NRAS
Signaling by FGFRR-HSA-1902364.673HRAS, KRAS, NRAS
Signaling by SCF-KITR-HSA-14335574.733HRAS, KRAS, NRAS
NCAM signaling for neurite out-growthR-HSA-3751654.93HRAS, KRAS, NRAS
DAP12 signalingR-HSA-24244914.643HRAS, KRAS, NRAS
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993HRAS, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.733HRAS, KRAS, NRAS
Negative regulation of MAPK pathwayR-HSA-56752217.663HRAS, KRAS, NRAS
Regulation of RAS by GAPsR-HSA-56584426.923HRAS, KRAS, NRAS
Signaling by GPCRR-HSA-3727902.683HRAS, KRAS, NRAS
Signalling to ERKsR-HSA-1876875.043HRAS, KRAS, NRAS
Signaling by FGFR4 in diseaseR-HSA-56552919.523HRAS, KRAS, NRAS
HemostasisR-HSA-1095823.983HRAS, KRAS, NRAS
Signal TransductionR-HSA-1625821.783HRAS, KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Interleukin-2 signaling (R-HSA-451927) -5.050.024HRAS, KRAS, NRAS
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.007HRAS, KRAS, NRAS
Signaling by VEGF (R-HSA-194138) -4.660.006HRAS, KRAS, NRAS
FCERI mediated MAPK activation (R-HSA-2871796) -4.320.013HRAS, KRAS, NRAS
IRS-mediated signalling (R-HSA-112399) -4.870.004HRAS, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.0HRAS, KRAS, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.0HRAS, KRAS, NRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.0HRAS, KRAS, NRAS
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.006HRAS, KRAS, NRAS
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.0HRAS, KRAS, NRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.006HRAS, KRAS, NRAS
DAP12 interactions (R-HSA-2172127) -4.560.008HRAS, KRAS, NRAS
Tie2 Signaling (R-HSA-210993) -8.810.0HRAS, KRAS, NRAS
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.006HRAS, KRAS, NRAS
Signaling by ERBB2 (R-HSA-1227986) -4.660.006HRAS, KRAS, NRAS
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.003HRAS, KRAS, NRAS
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.02HRAS, KRAS, NRAS
Frs2-mediated activation (R-HSA-170968) -5.120.02HRAS, KRAS, NRAS
Downstream signal transduction (R-HSA-186763) -4.650.007HRAS, KRAS, NRAS
RAF activation (R-HSA-5673000) -8.340.0HRAS, KRAS, NRAS
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.02HRAS, KRAS, NRAS
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.021HRAS, KRAS, NRAS
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.02HRAS, KRAS, NRAS
SOS-mediated signalling (R-HSA-112412) -5.150.02HRAS, KRAS, NRAS
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.02HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR3 (R-HSA-5654704) -8.810.0HRAS, KRAS, NRAS
Activation of RAS in B cells (R-HSA-1169092) -10.660.0HRAS, KRAS, NRAS
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.0HRAS, KRAS, NRAS
Signaling by FGFR in disease (R-HSA-1226099) -7.490.0HRAS, KRAS, NRAS
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.024HRAS, KRAS, NRAS
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.003HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.0HRAS, KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933) -9.810.0HRAS, KRAS, NRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.009HRAS, KRAS, NRAS
Prolonged ERK activation events (R-HSA-169893) -5.110.021HRAS, KRAS, NRAS
Signaling by FGFR2 (R-HSA-5654738) -4.680.006HRAS, KRAS, NRAS
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.02HRAS, KRAS, NRAS
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.02HRAS, KRAS, NRAS
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.02HRAS, KRAS, NRAS
EGFR Transactivation by Gastrin (R-HSA-2179392) -9.810.0HRAS, KRAS, NRAS
Axon guidance (R-HSA-422475) -3.930.029HRAS, KRAS, NRAS
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.0HRAS, KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.015HRAS, KRAS, NRAS
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.0HRAS, KRAS, NRAS
Signaling by Leptin (R-HSA-2586552) -5.10.022HRAS, KRAS, NRAS
MAP2K and MAPK activation (R-HSA-5674135) -7.660.0HRAS, KRAS, NRAS
IGF1R signaling cascade (R-HSA-2428924) -4.850.004HRAS, KRAS, NRAS
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.004HRAS, KRAS, NRAS
Signaling by Insulin receptor (R-HSA-74752) -4.730.006HRAS, KRAS, NRAS
Insulin receptor signalling cascade (R-HSA-74751) -4.850.004HRAS, KRAS, NRAS
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.006HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.0HRAS, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.008HRAS, KRAS, NRAS
C-type lectin receptors (CLRs) (R-HSA-5621481) -6.060.001HRAS, KRAS, NRAS
Diseases of signal transduction (R-HSA-5663202) -4.890.004HRAS, KRAS, NRAS
Signalling to RAS (R-HSA-167044) -5.080.023HRAS, KRAS, NRAS
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.0HRAS, KRAS, NRAS
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.006HRAS, KRAS, NRAS
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.02HRAS, KRAS, NRAS
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.02HRAS, KRAS, NRAS
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.02HRAS, KRAS, NRAS
Signaling by EGFR (R-HSA-177929) -4.590.007HRAS, KRAS, NRAS
ARMS-mediated activation (R-HSA-170984) -5.120.021HRAS, KRAS, NRAS
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.0HRAS, KRAS, NRAS
Signaling by FGFR1 (R-HSA-5654736) -4.690.006HRAS, KRAS, NRAS
Signaling by PDGF (R-HSA-186797) -4.530.008HRAS, KRAS, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.004HRAS, KRAS, NRAS
p38MAPK events (R-HSA-171007) -9.280.0HRAS, KRAS, NRAS
Signaling by Interleukins (R-HSA-449147) -4.710.006HRAS, KRAS, NRAS
Cell surface interactions at the vascular wall (R-HSA-202733) -6.320.0HRAS, KRAS, NRAS
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.044HRAS, KRAS, NRAS
Signaling by ERBB4 (R-HSA-1236394) -4.70.006HRAS, KRAS, NRAS
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.021HRAS, KRAS, NRAS
MAPK family signaling cascades (R-HSA-5683057) -4.890.037HRAS, KRAS, NRAS
Signalling by NGF (R-HSA-166520) -4.230.016HRAS, KRAS, NRAS
Transport to the Golgi and subsequent modification (R-HSA-948021) NEW7.810.019HRAS, KRAS
Signaling by FGFR4 (R-HSA-5654743) -4.690.006HRAS, KRAS, NRAS
Signaling by FGFR3 (R-HSA-5654741) -4.690.006HRAS, KRAS, NRAS
Signaling by FGFR (R-HSA-190236) -4.670.006HRAS, KRAS, NRAS
Signaling by SCF-KIT (R-HSA-1433557) -4.730.006HRAS, KRAS, NRAS
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.004HRAS, KRAS, NRAS
DAP12 signaling (R-HSA-2424491) -4.640.007HRAS, KRAS, NRAS
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.025HRAS, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.0HRAS, KRAS, NRAS
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.0HRAS, KRAS, NRAS
Regulation of RAS by GAPs (R-HSA-5658442) -6.920.0HRAS, KRAS, NRAS
Signalling to ERKs (R-HSA-187687) -5.040.026HRAS, KRAS, NRAS
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.0HRAS, KRAS, NRAS
Hemostasis (R-HSA-109582) -3.980.027HRAS, KRAS, NRAS
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein binding (GO:0005515) 0.463HRAS, KRAS, NRAS
guanyl nucleotide binding (GO:0019001) 3.733HRAS, KRAS, NRAS
purine ribonucleoside triphosphate binding (GO:0035639) 2.223HRAS, KRAS, NRAS
carbohydrate derivative binding (GO:0097367) 2.033HRAS, KRAS, NRAS
organic cyclic compound binding (GO:0097159) 1.053HRAS, KRAS, NRAS
nucleotide binding (GO:0000166) 1.963HRAS, KRAS, NRAS
small molecule binding (GO:0036094) 1.893HRAS, KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561) 3.733HRAS, KRAS, NRAS
purine ribonucleoside binding (GO:0032550) 2.223HRAS, KRAS, NRAS
ribonucleotide binding (GO:0032553) 2.193HRAS, KRAS, NRAS
binding (GO:0005488) 0.183HRAS, KRAS, NRAS
purine nucleoside binding (GO:0001883) 2.223HRAS, KRAS, NRAS
ribonucleoside binding (GO:0032549) 2.223HRAS, KRAS, NRAS
purine ribonucleotide binding (GO:0032555) 2.23HRAS, KRAS, NRAS
purine nucleotide binding (GO:0017076) 2.193HRAS, KRAS, NRAS
GTP binding (GO:0005525) 3.783HRAS, KRAS, NRAS
heterocyclic compound binding (GO:1901363) 1.063HRAS, KRAS, NRAS
nucleoside phosphate binding (GO:1901265) 1.963HRAS, KRAS, NRAS
nucleoside binding (GO:0001882) 2.213HRAS, KRAS, NRAS
hydrolase activity (GO:0016787) 1.92HRAS, KRAS
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032HRAS, KRAS
catalytic activity (GO:0003824) 1.052HRAS, KRAS
GTPase activity (GO:0003924) 4.312HRAS, KRAS
nucleoside-triphosphatase activity (GO:0017111) 3.092HRAS, KRAS
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032HRAS, KRAS
pyrophosphatase activity (GO:0016462) 3.042HRAS, KRAS
macromolecular complex binding (GO:0044877) 2.612KRAS, NRAS
protein complex binding (GO:0032403) 3.092KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
calcium-dependent protein binding (GO:0048306) NEW5.680.038HRAS, KRAS
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.043HRAS, KRAS, NRAS
NAD+ kinase activity (GO:0003951) NEW9.050.003HRAS, KRAS
acetylglucosaminyltransferase activity (GO:0008375) NEW5.850.014HRAS, KRAS
purine nucleoside binding (GO:0001883) -2.220.043HRAS, KRAS, NRAS
nucleoside binding (GO:0001882) -2.210.044HRAS, KRAS, NRAS
SH3/SH2 adaptor activity (GO:0005070) NEW5.790.028KRAS, NRAS
guanyl nucleotide binding (GO:0019001) -3.730.05HRAS, KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561) -3.730.0HRAS, KRAS, NRAS
ribonucleoside binding (GO:0032549) -2.220.044HRAS, KRAS, NRAS
purine nucleotide binding (GO:0017076) -2.190.047HRAS, KRAS, NRAS
phosphatidylserine binding (GO:0001786) NEW6.240.006HRAS, KRAS
GTP binding (GO:0005525) -3.780.0HRAS, KRAS, NRAS
NF-kappaB binding (GO:0051059) NEW6.340.004HRAS, KRAS
binding, bridging (GO:0060090) NEW4.570.003HRAS, KRAS, NRAS
protein binding, bridging (GO:0030674) NEW4.680.002HRAS, KRAS, NRAS
diacylglycerol kinase activity (GO:0004143) NEW7.340.003HRAS, KRAS
signaling adaptor activity (GO:0035591) NEW5.430.045KRAS, NRAS
GDP binding (GO:0019003) NEW5.810.019HRAS, KRAS
purine ribonucleotide binding (GO:0032555) -2.20.045HRAS, KRAS, NRAS
purine ribonucleoside binding (GO:0032550) -2.220.043HRAS, KRAS, NRAS
ribonucleotide binding (GO:0032553) -2.190.046HRAS, KRAS, NRAS
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
phosphorylation (GO:0016310) 2.633HRAS, KRAS, NRAS
positive regulation of response to stimulus (GO:0048584) 2.183HRAS, KRAS, NRAS
regulation of response to stimulus (GO:0048583) 1.543HRAS, KRAS, NRAS
axon guidance (GO:0007411) 4.443HRAS, KRAS, NRAS
movement of cell or subcellular component (GO:0006928) 2.613HRAS, KRAS, NRAS
positive regulation of defense response (GO:0031349) 3.833HRAS, KRAS, NRAS
leukocyte migration (GO:0050900) 4.193HRAS, KRAS, NRAS
signal transduction (GO:0007165) 1.283HRAS, KRAS, NRAS
cell surface receptor signaling pathway (GO:0007166) 2.093HRAS, KRAS, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243HRAS, KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.543HRAS, KRAS, NRAS
intracellular signal transduction (GO:0035556) 2.393HRAS, KRAS, NRAS
regulation of biological process (GO:0050789) 0.453HRAS, KRAS, NRAS
regulation of defense response (GO:0031347) 3.113HRAS, KRAS, NRAS
cellular protein metabolic process (GO:0044267) 1.633HRAS, KRAS, NRAS
single-organism metabolic process (GO:0044710) 1.633HRAS, KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264) 3.853HRAS, KRAS, NRAS
immune response-regulating signaling pathway (GO:0002764) 3.723HRAS, KRAS, NRAS
cellular macromolecule metabolic process (GO:0044260) 0.933HRAS, KRAS, NRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.963HRAS, KRAS, NRAS
MAPK cascade (GO:0000165) 3.913HRAS, KRAS, NRAS
Ras protein signal transduction (GO:0007265) 4.763HRAS, KRAS, NRAS
organic substance metabolic process (GO:0071704) 0.633HRAS, KRAS, NRAS
positive regulation of immune system process (GO:0002684) 2.963HRAS, KRAS, NRAS
regulation of immune system process (GO:0002682) 2.53HRAS, KRAS, NRAS
single-organism process (GO:0044699) 0.483HRAS, KRAS, NRAS
positive regulation of biological process (GO:0048518) 1.23HRAS, KRAS, NRAS
biological regulation (GO:0065007) 0.393HRAS, KRAS, NRAS
signal transduction by protein phosphorylation (GO:0023014) 3.793HRAS, KRAS, NRAS
cell migration (GO:0016477) 3.123HRAS, KRAS, NRAS
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.073HRAS, KRAS, NRAS
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.093HRAS, KRAS, NRAS
protein phosphorylation (GO:0006468) 2.893HRAS, KRAS, NRAS
cellular process (GO:0009987) 0.263HRAS, KRAS, NRAS
positive regulation of innate immune response (GO:0045089) 4.223HRAS, KRAS, NRAS
regulation of innate immune response (GO:0045088) 3.863HRAS, KRAS, NRAS
regulation of immune response (GO:0050776) 2.983HRAS, KRAS, NRAS
cellular protein modification process (GO:0006464) 1.793HRAS, KRAS, NRAS
regulation of cellular process (GO:0050794) 0.53HRAS, KRAS, NRAS
macromolecule modification (GO:0043412) 1.733HRAS, KRAS, NRAS
immune response-activating signal transduction (GO:0002757) 3.83HRAS, KRAS, NRAS
single-organism cellular process (GO:0044763) 0.653HRAS, KRAS, NRAS
metabolic process (GO:0008152) 0.583HRAS, KRAS, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095) 4.843HRAS, KRAS, NRAS
ERBB2 signaling pathway (GO:0038128) 6.093HRAS, KRAS, NRAS
neuron projection guidance (GO:0097485) 4.433HRAS, KRAS, NRAS
locomotion (GO:0040011) 2.913HRAS, KRAS, NRAS
primary metabolic process (GO:0044238) 0.693HRAS, KRAS, NRAS
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.063HRAS, KRAS, NRAS
Fc receptor signaling pathway (GO:0038093) 4.453HRAS, KRAS, NRAS
cell motility (GO:0048870) 3.023HRAS, KRAS, NRAS
protein metabolic process (GO:0019538) 1.453HRAS, KRAS, NRAS
regulation of response to stress (GO:0080134) 2.533HRAS, KRAS, NRAS
innate immune response-activating signal transduction (GO:0002758) 4.453HRAS, KRAS, NRAS
positive regulation of immune response (GO:0050778) 3.43HRAS, KRAS, NRAS
cellular metabolic process (GO:0044237) 0.693HRAS, KRAS, NRAS
macromolecule metabolic process (GO:0043170) 0.833HRAS, KRAS, NRAS
immune system process (GO:0002376) 2.293HRAS, KRAS, NRAS
activation of innate immune response (GO:0002218) 4.413HRAS, KRAS, NRAS
phosphate-containing compound metabolic process (GO:0006796) 2.163HRAS, KRAS, NRAS
protein modification process (GO:0036211) 1.793HRAS, KRAS, NRAS
activation of immune response (GO:0002253) 3.673HRAS, KRAS, NRAS
phosphorus metabolic process (GO:0006793) 2.153HRAS, KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173) 5.723HRAS, KRAS, NRAS
ERBB signaling pathway (GO:0038127) 5.363HRAS, KRAS, NRAS
regulation of phosphate metabolic process (GO:0019220) 2.352HRAS, KRAS
regulation of primary metabolic process (GO:0080090) 1.082HRAS, KRAS
regulation of metabolic process (GO:0019222) 1.022HRAS, KRAS
behavior (GO:0007610) 3.472HRAS, KRAS
regulation of neuron apoptotic process (GO:0043523) 4.472HRAS, KRAS
negative regulation of neuron apoptotic process (GO:0043524) 4.822HRAS, KRAS
cellular component organization or biogenesis (GO:0071840) 1.222HRAS, KRAS
positive regulation of macromolecule metabolic process (GO:0010604) 1.812HRAS, KRAS
regulation of signal transduction (GO:0009966) 1.842HRAS, KRAS
cellular developmental process (GO:0048869) 1.822HRAS, KRAS
positive regulation of molecular function (GO:0044093) 2.232HRAS, KRAS
negative regulation of biological process (GO:0048519) 1.332HRAS, KRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057) 6.042HRAS, KRAS
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082HRAS, KRAS
social behavior (GO:0035176) 5.92HRAS, KRAS
negative regulation of cell death (GO:0060548) 2.952HRAS, KRAS
regulation of protein kinase activity (GO:0045859) 3.152HRAS, KRAS
regulation of RNA biosynthetic process (GO:2001141) 1.552HRAS, KRAS
intraspecies interaction between organisms (GO:0051703) 5.92HRAS, KRAS
multi-organism behavior (GO:0051705) 5.62HRAS, KRAS
multi-organism process (GO:0051704) 2.652HRAS, KRAS
regulation of phosphorylation (GO:0042325) 2.52HRAS, KRAS
positive regulation of phosphorylation (GO:0042327) 2.92HRAS, KRAS
positive regulation of metabolic process (GO:0009893) 1.742HRAS, KRAS
negative regulation of neuron death (GO:1901215) 4.572HRAS, KRAS
positive regulation of kinase activity (GO:0033674) 3.542HRAS, KRAS
regulation of synaptic plasticity (GO:0048167) 4.782HRAS, KRAS
positive regulation of gene expression (GO:0010628) 2.352HRAS, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062HRAS, KRAS
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582HRAS, KRAS
regulation of apoptotic process (GO:0042981) 2.52HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168) 5.842HRAS, KRAS
regulation of cell communication (GO:0010646) 1.732HRAS, KRAS
positive regulation of transferase activity (GO:0051347) 3.312HRAS, KRAS
regulation of kinase activity (GO:0043549) 3.072HRAS, KRAS
cellular component organization (GO:0016043) 1.242HRAS, KRAS
regulation of molecular function (GO:0065009) 1.782HRAS, KRAS
regulation of biological quality (GO:0065008) 1.682HRAS, KRAS
regulation of catalytic activity (GO:0050790) 1.972HRAS, KRAS
regulation of biosynthetic process (GO:0009889) 1.372HRAS, KRAS
positive regulation of MAPK cascade (GO:0043410) 3.572HRAS, KRAS
positive regulation of intracellular signal transduction (GO:1902533) 2.952HRAS, KRAS
regulation of neuron death (GO:1901214) 4.192HRAS, KRAS
establishment of localization (GO:0051234) 1.482HRAS, NRAS
single-organism developmental process (GO:0044767) 1.492HRAS, KRAS
response to stimulus (GO:0050896) 1.222HRAS, KRAS
positive regulation of protein modification process (GO:0031401) 2.72HRAS, KRAS
regulation of transferase activity (GO:0051338) 2.882HRAS, KRAS
developmental process (GO:0032502) 1.362HRAS, KRAS
regulation of transcription, DNA-templated (GO:0006355) 1.562HRAS, KRAS
regulation of macromolecule biosynthetic process (GO:0010556) 1.432HRAS, KRAS
positive regulation of signal transduction (GO:0009967) 2.52HRAS, KRAS
regulation of synapse structure or activity (GO:0050803) 4.772HRAS, KRAS
regulation of Ras protein signal transduction (GO:0046578) 4.492HRAS, KRAS
positive regulation of Ras protein signal transduction (GO:0046579) 6.22HRAS, KRAS
modulation of synaptic transmission (GO:0050804) 4.092HRAS, KRAS
positive regulation of signaling (GO:0023056) 2.412HRAS, KRAS
positive regulation of MAP kinase activity (GO:0043406) 4.392HRAS, KRAS
regulation of MAP kinase activity (GO:0043405) 3.952HRAS, KRAS
regulation of signaling (GO:0023051) 1.722HRAS, KRAS
positive regulation of cell communication (GO:0010647) 2.412HRAS, KRAS
anatomical structure morphogenesis (GO:0009653) 2.532HRAS, KRAS
positive regulation of catalytic activity (GO:0043085) 2.42HRAS, KRAS
regulation of MAPK cascade (GO:0043408) 3.222HRAS, KRAS
regulation of intracellular signal transduction (GO:1902531) 2.312HRAS, KRAS
positive regulation of phosphorus metabolic process (GO:0010562) 2.782HRAS, KRAS
regulation of protein metabolic process (GO:0051246) 1.932HRAS, KRAS
positive regulation of protein metabolic process (GO:0051247) 2.432HRAS, KRAS
positive regulation of cellular protein metabolic process (GO:0032270) 2.492HRAS, KRAS
regulation of protein modification process (GO:0031399) 2.322HRAS, KRAS
positive regulation of cell proliferation (GO:0008284) 3.012HRAS, KRAS
regulation of nucleic acid-templated transcription (GO:1903506) 1.552HRAS, KRAS
regulation of cellular protein metabolic process (GO:0032268) 1.992HRAS, KRAS
regulation of RNA metabolic process (GO:0051252) 1.522HRAS, KRAS
positive regulation of protein kinase activity (GO:0045860) 3.612HRAS, KRAS
regulation of cell proliferation (GO:0042127) 2.412HRAS, KRAS
regulation of cellular biosynthetic process (GO:0031326) 1.382HRAS, KRAS
positive regulation of cellular metabolic process (GO:0031325) 1.812HRAS, KRAS
regulation of cellular metabolic process (GO:0031323) 1.072HRAS, KRAS
regulation of cell death (GO:0010941) 2.432HRAS, KRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) 6.552HRAS, KRAS
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462HRAS, KRAS
regulation of macromolecule metabolic process (GO:0060255) 1.082HRAS, KRAS
regulation of programmed cell death (GO:0043067) 2.492HRAS, KRAS
negative regulation of apoptotic process (GO:0043066) 3.042HRAS, KRAS
negative regulation of programmed cell death (GO:0043069) 3.022HRAS, KRAS
regulation of gene expression (GO:0010468) 1.372HRAS, KRAS
positive regulation of phosphate metabolic process (GO:0045937) 2.782HRAS, KRAS
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432HRAS, KRAS
regulation of phosphorus metabolic process (GO:0051174) 2.352HRAS, KRAS
regulation of nitrogen compound metabolic process (GO:0051171) 1.362HRAS, KRAS
localization (GO:0051179) 1.42HRAS, NRAS
regulation of protein phosphorylation (GO:0001932) 2.572HRAS, KRAS
positive regulation of protein phosphorylation (GO:0001934) 2.952HRAS, KRAS
negative regulation of cellular process (GO:0048523) 1.412HRAS, KRAS
positive regulation of cellular process (GO:0048522) 1.32HRAS, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
hemostasis (GO:0007599) NEW4.50.007HRAS, KRAS, NRAS
organophosphate catabolic process (GO:0046434) NEW5.030.023HRAS, KRAS, NRAS
blood coagulation (GO:0007596) NEW4.520.007HRAS, KRAS, NRAS
learning (GO:0007612) NEW4.850.011HRAS, KRAS, NRAS
activation of protein kinase activity (GO:0032147) NEW4.080.001HRAS, KRAS, NRAS
behavior (GO:0007610) -3.470.008HRAS, KRAS, NRAS
learning or memory (GO:0007611) NEW4.330.001HRAS, KRAS, NRAS
nucleotide catabolic process (GO:0009166) NEW5.670.019HRAS, KRAS, NRAS
nucleoside catabolic process (GO:0009164) NEW6.170.017HRAS, KRAS, NRAS
regulation of neuron apoptotic process (GO:0043523) -4.470.0HRAS, KRAS, NRAS
negative regulation of neuron apoptotic process (GO:0043524) -4.820.013HRAS, KRAS, NRAS
GTP metabolic process (GO:0046039) NEW6.590.001HRAS, KRAS, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.029HRAS, KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.012HRAS, KRAS, NRAS
purine ribonucleoside catabolic process (GO:0046130) NEW7.160.015HRAS, KRAS, NRAS
signal transduction by phosphorylation (GO:0023014) -3.790.001HRAS, KRAS, NRAS
purine ribonucleoside metabolic process (GO:0046128) NEW4.330.027HRAS, KRAS, NRAS
MAPK cascade (GO:0000165) -3.910.0HRAS, KRAS, NRAS
response to growth factor (GO:0070848) NEW4.140.013HRAS, KRAS, NRAS
ribonucleoside triphosphate metabolic process (GO:0009199) NEW4.770.02HRAS, KRAS, NRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057) -6.040.0HRAS, KRAS, NRAS
regulation of small GTPase mediated signal transduction (GO:0051056) -4.080.001HRAS, KRAS, NRAS
purine ribonucleoside triphosphate metabolic process (GO:0009205) NEW4.810.02HRAS, KRAS, NRAS
neurotrophin signaling pathway (GO:0038179) NEW6.550.001HRAS, KRAS, NRAS
social behavior (GO:0035176) -5.90.006HRAS, KRAS
negative regulation of cell death (GO:0060548) -2.950.027HRAS, KRAS, NRAS
regulation of protein kinase activity (GO:0045859) -3.150.023HRAS, KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.0HRAS, KRAS, NRAS
intraspecies interaction between organisms (GO:0051703) -5.90.006HRAS, KRAS
response to peptide hormone (GO:0043434) NEW4.060.003HRAS, KRAS, NRAS
neuron projection guidance (GO:0097485) -4.430.003HRAS, KRAS, NRAS
multi-organism behavior (GO:0051705) -5.60.023HRAS, KRAS
ribonucleoside catabolic process (GO:0042454) NEW6.550.016HRAS, KRAS, NRAS
positive regulation of phosphorylation (GO:0042327) -2.90.031HRAS, KRAS, NRAS
cell motility (GO:0048870) -3.020.027HRAS, KRAS, NRAS
single-organism behavior (GO:0044708) NEW3.790.003HRAS, KRAS, NRAS
response to organonitrogen compound (GO:0010243) NEW3.20.021HRAS, KRAS, NRAS
regulation of synaptic transmission, GABAergic (GO:0032228) NEW6.360.0HRAS, KRAS, NRAS
purine nucleotide metabolic process (GO:0006163) NEW4.090.034HRAS, KRAS, NRAS
response to hormone (GO:0009725) NEW3.330.032HRAS, KRAS, NRAS
response to light stimulus (GO:0009416) NEW4.080.002HRAS, KRAS, NRAS
muscle cell differentiation (GO:0042692) NEW5.090.011HRAS, KRAS, NRAS
visual behavior (GO:0007632) NEW5.820.001HRAS, KRAS, NRAS
positive regulation of kinase activity (GO:0033674) -3.540.007HRAS, KRAS, NRAS
nucleoside triphosphate metabolic process (GO:0009141) NEW4.610.022HRAS, KRAS, NRAS
nucleoside triphosphate catabolic process (GO:0009143) NEW7.240.015HRAS, KRAS, NRAS
purine nucleoside triphosphate metabolic process (GO:0009144) NEW4.760.02HRAS, KRAS, NRAS
purine nucleoside triphosphate catabolic process (GO:0009146) NEW7.940.014HRAS, KRAS, NRAS
positive regulation of cell proliferation (GO:0008284) -3.010.03HRAS, KRAS, NRAS
regulation of synaptic plasticity (GO:0048167) -4.780.012HRAS, KRAS, NRAS
morphogenesis of a branching structure (GO:0001763) NEW4.710.0HRAS, KRAS, NRAS
purine nucleotide catabolic process (GO:0006195) NEW6.070.017HRAS, KRAS, NRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) -6.550.0HRAS, KRAS, NRAS
regulation of neuronal synaptic plasticity (GO:0048168) -5.840.0HRAS, KRAS, NRAS
positive regulation of transferase activity (GO:0051347) -3.310.012HRAS, KRAS, NRAS
positive regulation of phosphate metabolic process (GO:0045937) -2.780.044HRAS, KRAS, NRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.006HRAS, KRAS, NRAS
regulation of kinase activity (GO:0043549) -3.070.027HRAS, KRAS, NRAS
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.023HRAS, KRAS, NRAS
ribonucleotide metabolic process (GO:0009259) NEW4.110.033HRAS, KRAS, NRAS
guanosine-containing compound catabolic process (GO:1901069) NEW8.630.001HRAS, KRAS, NRAS
guanosine-containing compound metabolic process (GO:1901068) NEW5.90.001HRAS, KRAS, NRAS
cell migration (GO:0016477) -3.120.02HRAS, KRAS, NRAS
purine ribonucleoside triphosphate catabolic process (GO:0009207) NEW9.730.014HRAS, KRAS, NRAS
purine ribonucleotide catabolic process (GO:0009154) NEW6.470.016HRAS, KRAS, NRAS
purine ribonucleotide metabolic process (GO:0009150) NEW4.160.031HRAS, KRAS, NRAS
ribonucleotide catabolic process (GO:0009261) NEW6.430.016HRAS, KRAS, NRAS
associative learning (GO:0008306) NEW5.440.0HRAS, KRAS, NRAS
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.001HRAS, KRAS, NRAS
positive regulation of intracellular signal transduction (GO:1902533) -2.950.022HRAS, KRAS, NRAS
regulation of neuron death (GO:1901214) -4.190.001HRAS, KRAS, NRAS
negative regulation of neuron death (GO:1901215) -4.570.0HRAS, KRAS, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095) -4.840.002HRAS, KRAS, NRAS
Fc receptor signaling pathway (GO:0038093) -4.450.003HRAS, KRAS, NRAS
response to nitrogen compound (GO:1901698) NEW3.120.027HRAS, KRAS, NRAS
cellular response to nitrogen compound (GO:1901699) NEW3.790.006HRAS, KRAS, NRAS
cognition (GO:0050890) NEW4.20.001HRAS, KRAS, NRAS
regulation of transferase activity (GO:0051338) -2.880.041HRAS, KRAS, NRAS
coagulation (GO:0050817) NEW4.510.007HRAS, KRAS, NRAS
nucleoside phosphate catabolic process (GO:1901292) NEW5.540.019HRAS, KRAS, NRAS
response to fibroblast growth factor (GO:0071774) NEW6.170.0HRAS, KRAS, NRAS
response to radiation (GO:0009314) NEW3.690.006HRAS, KRAS, NRAS
regulation of Ras protein signal transduction (GO:0046578) -4.490.0HRAS, KRAS, NRAS
positive regulation of Ras protein signal transduction (GO:0046579) -6.20.0HRAS, KRAS, NRAS
regulation of synaptic transmission (GO:0050804) -4.090.001HRAS, KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020) NEW7.240.0HRAS, KRAS, NRAS
ERBB signaling pathway (GO:0038127) -5.360.0HRAS, KRAS, NRAS
positive regulation of Rac protein signal transduction (GO:0035022) NEW8.630.0HRAS, KRAS, NRAS
axon guidance (GO:0007411) -4.440.003HRAS, KRAS, NRAS
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.0HRAS, KRAS, NRAS
visual learning (GO:0008542) NEW5.920.0HRAS, KRAS, NRAS
regulation of MAPK cascade (GO:0043408) -3.220.01HRAS, KRAS, NRAS
cellular response to peptide hormone stimulus (GO:0071375) NEW4.630.001HRAS, KRAS, NRAS
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.044HRAS, KRAS, NRAS
purine nucleoside metabolic process (GO:0042278) NEW4.320.028HRAS, KRAS, NRAS
epithelial tube branching involved in lung morphogenesis (GO:0060441) NEW6.90.0HRAS, KRAS, NRAS
cellular response to endogenous stimulus (GO:0071495) NEW3.330.044HRAS, KRAS, NRAS
insulin receptor signaling pathway (GO:0008286) NEW5.330.009HRAS, KRAS, NRAS
regulation of body fluid levels (GO:0050878) NEW3.760.014HRAS, KRAS, NRAS
neurological system process (GO:0050877) NEW2.640.027HRAS, KRAS, NRAS
negative regulation of cell differentiation (GO:0045596) NEW3.330.01HRAS, KRAS, NRAS
cellular response to hormone stimulus (GO:0032870) NEW3.990.007HRAS, KRAS, NRAS
actin cytoskeleton organization (GO:0030036) NEW4.10.001HRAS, KRAS, NRAS
negative regulation of developmental process (GO:0051093) NEW3.170.02HRAS, KRAS, NRAS
monocyte chemotaxis (GO:0002548) NEW6.040.024HRAS, KRAS
cellular response to growth factor stimulus (GO:0071363) NEW4.270.012HRAS, KRAS, NRAS
carbohydrate derivative catabolic process (GO:1901136) NEW4.610.029HRAS, KRAS, NRAS
ribonucleoside triphosphate catabolic process (GO:0009203) NEW9.730.014HRAS, KRAS, NRAS
positive regulation of protein kinase activity (GO:0045860) -3.610.006HRAS, KRAS, NRAS
activation of MAPKK activity (GO:0000186) NEW5.740.0HRAS, KRAS, NRAS
positive regulation of protein modification process (GO:0031401) -2.70.041HRAS, KRAS, NRAS
striated muscle cell differentiation (GO:0051146) NEW5.690.0HRAS, KRAS, NRAS
branching morphogenesis of an epithelial tube (GO:0048754) NEW4.930.021HRAS, KRAS, NRAS
leukocyte migration (GO:0050900) -4.190.001HRAS, KRAS, NRAS
response to insulin (GO:0032868) NEW4.720.001HRAS, KRAS, NRAS
cellular response to insulin stimulus (GO:0032869) NEW5.290.0HRAS, KRAS, NRAS
purine-containing compound metabolic process (GO:0072521) NEW4.00.04HRAS, KRAS, NRAS
purine-containing compound catabolic process (GO:0072523) NEW5.920.018HRAS, KRAS, NRAS
morphogenesis of an epithelium (GO:0002009) NEW4.080.002HRAS, KRAS, NRAS
cellular response to organonitrogen compound (GO:0071417) NEW3.870.005HRAS, KRAS, NRAS
negative regulation of apoptotic process (GO:0043066) -3.040.021HRAS, KRAS, NRAS
tissue morphogenesis (GO:0048729) NEW3.870.003HRAS, KRAS, NRAS
purine nucleoside catabolic process (GO:0006152) NEW7.160.015HRAS, KRAS, NRAS
negative regulation of programmed cell death (GO:0043069) -3.020.022HRAS, KRAS, NRAS
ribonucleoside metabolic process (GO:0009119) NEW4.210.03HRAS, KRAS, NRAS
actin filament-based process (GO:0030029) NEW3.940.002HRAS, KRAS, NRAS
morphogenesis of a branching epithelium (GO:0061138) NEW4.770.0HRAS, KRAS, NRAS
innate immune response (GO:0045087) NEW3.550.033HRAS, KRAS, NRAS
nucleoside metabolic process (GO:0009116) NEW4.120.034HRAS, KRAS, NRAS
Ras protein signal transduction (GO:0007265) -4.760.016HRAS, KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264) -3.850.007HRAS, KRAS, NRAS
immune response-regulating signaling pathway (GO:0002764) -3.720.011HRAS, KRAS, NRAS
locomotion (GO:0040011) -2.910.041HRAS, KRAS, NRAS
cellular response to oxygen-containing compound (GO:1901701) NEW3.220.024HRAS, KRAS, NRAS
cytoskeleton organization (GO:0007010) NEW3.220.017HRAS, KRAS, NRAS
ribose phosphate metabolic process (GO:0019693) NEW4.060.034HRAS, KRAS, NRAS
glycosyl compound metabolic process (GO:1901657) NEW4.040.036HRAS, KRAS, NRAS
response to peptide (GO:1901652) NEW3.940.004HRAS, KRAS, NRAS
cellular response to peptide (GO:1901653) NEW4.520.001HRAS, KRAS, NRAS
positive regulation of protein phosphorylation (GO:0001934) -2.950.019HRAS, KRAS, NRAS
glycosyl compound catabolic process (GO:1901658) NEW6.020.017HRAS, KRAS, NRAS
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63HRAS, KRAS, NRAS
membrane (GO:0016020) 0.683HRAS, KRAS, NRAS
cell part (GO:0044464) 0.113HRAS, KRAS, NRAS
cytoplasmic part (GO:0044444) 0.823HRAS, KRAS, NRAS
intracellular (GO:0005622) 2.373HRAS, KRAS, NRAS
intracellular organelle (GO:0043229) 0.513HRAS, KRAS, NRAS
plasma membrane (GO:0005886) 1.393HRAS, KRAS, NRAS
intracellular part (GO:0044424) 0.283HRAS, KRAS, NRAS
membrane-bounded organelle (GO:0043227) 0.473HRAS, KRAS, NRAS
organelle (GO:0043226) 0.43HRAS, KRAS, NRAS
cytoplasm (GO:0005737) 1.012HRAS, KRAS
Golgi apparatus (GO:0005794) 2.72HRAS, NRAS
organelle membrane (GO:0031090) 1.972HRAS, NRAS
bounding membrane of organelle (GO:0098588) 2.392HRAS, NRAS
Golgi membrane (GO:0000139) 3.282HRAS, NRAS
intracellular organelle part (GO:0044446) 0.812HRAS, NRAS
Golgi apparatus part (GO:0044431) 3.02HRAS, NRAS
cytosol (GO:0005829) 1.682HRAS, KRAS
organelle part (GO:0044422) 0.792HRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
protein kinase complex (GO:1902911) NEW5.310.035HRAS, KRAS
Golgi cisterna membrane (GO:0032580) NEW5.50.048HRAS, KRAS
endosomal part (GO:0044440) NEW3.730.034HRAS, KRAS, NRAS
endosome membrane (GO:0010008) NEW3.830.03HRAS, KRAS, NRAS