Disease table of BLADDER CANCER OMIM ID: 109800

Gene-disease associations table

GeneAssociated with BLADDER CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HRASOMIMHGNC link11p15.56218040, 137550, 185500, 109800, 163200, 162900
FGFR3OMIM, HUMSAVARHGNC link4p16.316603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482
RB1OMIMHGNC link13q14.24109800, 180200, 259500, 182280
KRASOMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
RB1YES29CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F31RB1
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12RB1, KRAS
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12FGFR3, HRAS
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING12HRAS, RB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HRASYES3SP1, MAZ, TP530
FGFR3YES5SP1, SP3, SP4, STAT1, SHOX0
RB1YES19KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX51RB1
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HRASRB1No3RAF1, TP53, DGKZ
HRASKRASNo10RALGDS, RASSF5, RGL2, IL24, PIK3CA, BTRC, RAF1, PIK3CG, RAP1GDS1, SHOC2
FGFR3RB1No1GRB2
RB1KRASNo3PHB, PML, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RB1KRASNo1TAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
HRASFGFR3Yesactivation, binding18INS, ANGPT1, KITLG, HGF, CBL, SOS2, SHC2, SHC1, SH3KBP1, SHC3, IRS1, IGF1, SOS1, EGF, PDGFB, VEGFA, GRB2, CSF1
HRASRB1No-19SP1, INS, AR, RAF1, MET, MAPK1, CCND1, ABL1, SOCS1, MAP3K5, TP53, UBC, JUN, GNB2L1, AKT1, NPM1, SRC, MAPK14, MDM4
HRASKRASYesbinding111RASA1, AKT1, RASSF4, TP53, MAP3K2, PIK3CA, EGFR, GAST, NCAM1, YWHAB, SPTAN1, PPARD, PTK2, MAPK14, RET, CALM1, SLC3A2, MAPK13, RPS6KB1, JUN, ETS2, ABL1, SPTBN5, CCR5, TNS4, MAPK3, BTRC, MTOR, FRS2, MAZ, MAP3K3, ARAF, KSR2, IL8, LGALS3, JUND, RASGRP3, SPTBN1, DDX43, TEK, KSR1, CNKSR3, SHC3, RGL4, NPM1, GRB2, RASGRF2, MAP3K19, RALGDS, SPTA1, RASA2, CDX1, SPRY2, UBC, MLLT4, MAP2K2, BMP4, NT5E, SPTBN4, HBEGF, FYN, RGL1, RASSF2, MAPK11, CCND1, SHC2, ERBB3, ETS1, RAF1, SHOC2, KIT, LGALS1, PTPRA, VEGFA, MAPK12, YES1, MGMT, SPTB, MEN1, RASGRP1, RASA3, PIK3CD, MDM4, PTPN11, PIK3CG, IGF2BP1, ANGPT1, ITSN1, MAP2K1, SOS1, EPHA2, ERBB2, MECOM, SHC1, MAPK7, NCL, AKT2, CDX2, SPTBN2, EGF, RASSF7, SRC, BCL2L11, NOTCH1, BCL2, MAPK1, PIK3CB, IRS1, IRS2, BRAF, ERBB4
FGFR3RB1No-4INS, STAT3, MDM2, HSP90AA1
FGFR3KRASNo-12HSP90AA1, ANGPT1, HRAS, PRMT5, IRS1, SHC3, SHC2, SOS1, EGF, SHC1, VEGFA, GRB2
RB1KRASNo-15HSP90AA1, ABL1, CCND1, MAPK1, TP53, PPP2CA, UBC, JUN, RAF1, CEBPD, NPM1, AKT1, SRC, MAPK14, MDM4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
HRASKRASYesRAF1-RAS complex, EGF induced2NRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
HRASKRASNo
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Bladder cancerhsa052197.384FGFR3, HRAS, RB1, KRAS
Pathways in cancerhsa052003.984FGFR3, HRAS, RB1, KRAS
Melanomahsa052186.563HRAS, RB1, KRAS
MAPK signaling pathwayhsa040104.633FGFR3, HRAS, KRAS
MicroRNAs in cancerhsa052065.383FGFR3, HRAS, KRAS
Signaling pathways regulating pluripotency of stem cellshsa045505.63FGFR3, HRAS, KRAS
Gliomahsa052146.663HRAS, RB1, KRAS
Prostate cancerhsa052156.113HRAS, RB1, KRAS
Rap1 signaling pathwayhsa040154.973FGFR3, HRAS, KRAS
Ras signaling pathwayhsa040144.93FGFR3, HRAS, KRAS
Central carbon metabolism in cancerhsa052306.73FGFR3, HRAS, KRAS
Viral carcinogenesishsa052035.083HRAS, RB1, KRAS
Chronic myeloid leukemiahsa052206.483HRAS, RB1, KRAS
Non-small cell lung cancerhsa052236.883HRAS, RB1, KRAS
HTLV-I infectionhsa051664.593HRAS, RB1, KRAS
Regulation of actin cytoskeletonhsa048104.93FGFR3, HRAS, KRAS
Hepatitis Bhsa051615.523HRAS, RB1, KRAS
PI3K-Akt signaling pathwayhsa041514.213FGFR3, HRAS, KRAS
Pancreatic cancerhsa052126.562RB1, KRAS
Natural killer cell mediated cytotoxicityhsa046505.532HRAS, KRAS
Renal cell carcinomahsa052116.62HRAS, KRAS
Thyroid cancerhsa052167.482HRAS, KRAS
Tight junctionhsa045305.532HRAS, KRAS
Long-term potentiationhsa047206.642HRAS, KRAS
Neurotrophin signaling pathwayhsa047225.782HRAS, KRAS
Cholinergic synapsehsa047255.882HRAS, KRAS
Endocytosishsa041444.922FGFR3, HRAS
FoxO signaling pathwayhsa040685.632HRAS, KRAS
Serotonergic synapsehsa047265.842HRAS, KRAS
Chemokine signaling pathwayhsa040625.192HRAS, KRAS
Oxytocin signaling pathwayhsa049215.42HRAS, KRAS
ErbB signaling pathwayhsa040126.152HRAS, KRAS
Endometrial cancerhsa052136.812HRAS, KRAS
Hepatitis Chsa051605.682HRAS, KRAS
Gap junctionhsa045406.242HRAS, KRAS
VEGF signaling pathwayhsa043706.772HRAS, KRAS
Proteoglycans in cancerhsa052055.022HRAS, KRAS
T cell receptor signaling pathwayhsa046606.012HRAS, KRAS
B cell receptor signaling pathwayhsa046626.522HRAS, KRAS
Melanogenesishsa049165.972HRAS, KRAS
Prolactin signaling pathwayhsa049176.62HRAS, KRAS
Acute myeloid leukemiahsa052216.742HRAS, KRAS
Estrogen signaling pathwayhsa049156.112HRAS, KRAS
Thyroid hormone signaling pathwayhsa049195.822HRAS, KRAS
Long-term depressionhsa047306.742HRAS, KRAS
GnRH signaling pathwayhsa049126.182HRAS, KRAS
Insulin signaling pathwayhsa049105.552HRAS, KRAS
Alcoholismhsa050345.592HRAS, KRAS
Axon guidancehsa043605.632HRAS, KRAS
Fc epsilon RI signaling pathwayhsa046646.62HRAS, KRAS
Choline metabolism in cancerhsa052316.092HRAS, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.0FGFR3, HRAS, RB1, KRAS
Bladder cancer (hsa05219) -7.380.0FGFR3, HRAS, RB1, KRAS
Acute myeloid leukemia (hsa05221) -6.740.001HRAS, RB1, KRAS
Pancreatic cancer (hsa05212) -6.560.001HRAS, RB1, KRAS
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.014HRAS, RB1, KRAS
Chronic myeloid leukemia (hsa05220) -6.480.0HRAS, RB1, KRAS
Thyroid cancer (hsa05216) -7.480.014HRAS, KRAS
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.003FGFR3, HRAS, RB1, KRAS
Glioma (hsa05214) -6.660.0HRAS, RB1, KRAS
Prostate cancer (hsa05215) -6.110.003HRAS, RB1, KRAS
Nervous systemNEW3.770.042FGFR3, HRAS, RB1, KRAS
Excretory systemNEW5.450.025HRAS, RB1, KRAS
Neurotrophin signaling pathway (hsa04722) -5.780.012FGFR3, HRAS, KRAS
Central carbon metabolism in cancer (hsa05230) -6.70.0FGFR3, HRAS, KRAS
FoxO signaling pathway (hsa04068) -5.630.03HRAS, RB1, KRAS
DevelopmentNEW4.580.005FGFR3, HRAS, RB1, KRAS
Endometrial cancer (hsa05213) -6.810.036HRAS, KRAS
HTLV-I infection (hsa05166) -4.590.021HRAS, RB1, KRAS
PI3K-Akt signaling pathway (hsa04151) -4.210.012FGFR3, HRAS, RB1, KRAS
Hepatitis C (hsa05160) -5.680.015HRAS, RB1, KRAS
Hepatitis B (hsa05161) -5.520.003HRAS, RB1, KRAS
Cancers: OverviewNEW2.720.041FGFR3, HRAS, RB1, KRAS
Cancers: Specific typesNEW4.10.001FGFR3, HRAS, RB1, KRAS
VEGF signaling pathway (hsa04370) -6.770.038HRAS, KRAS
Estrogen signaling pathway (hsa04915) -6.110.006HRAS, RB1, KRAS
MicroRNAs in cancer (hsa05206) -5.380.004FGFR3, HRAS, RB1, KRAS
Pathways in cancer (hsa05200) -3.980.001FGFR3, HRAS, RB1, KRAS
Viral carcinogenesis (hsa05203) -5.080.008HRAS, RB1, KRAS
T cell receptor signaling pathway (hsa04660) -6.010.006HRAS, RB1, KRAS
Rap1 signaling pathway (hsa04015) -4.970.01FGFR3, HRAS, KRAS
Ras signaling pathway (hsa04014) -4.90.011FGFR3, HRAS, KRAS
Non-small cell lung cancer (hsa05223) -6.880.0HRAS, RB1, KRAS
Prolactin signaling pathway (hsa04917) -6.60.049HRAS, KRAS
Progesterone-mediated oocyte maturation (hsa04914) NEW6.180.004HRAS, RB1, KRAS
MAPK signaling pathway (hsa04010) -4.630.02FGFR3, HRAS, KRAS
Thyroid hormone signaling pathway (hsa04919) -5.820.009HRAS, RB1, KRAS
Cell motilityNEW4.90.011FGFR3, HRAS, KRAS
Long-term depression (hsa04730) -6.740.04HRAS, KRAS
Regulation of actin cytoskeleton (hsa04810) -4.90.011FGFR3, HRAS, KRAS
Long-term potentiation (hsa04720) -6.640.046HRAS, KRAS
Renal cell carcinoma (hsa05211) -6.60.049HRAS, KRAS
Glycosphingolipid biosynthesis - lacto and neolacto series (hsa00601) NEW7.860.039HRAS, KRAS
Alcoholism (hsa05034) -5.590.021HRAS, RB1, KRAS
Cholinergic synapse (hsa04725) -5.880.008HRAS, RB1, KRAS
Fc epsilon RI signaling pathway (hsa04664) -6.60.049HRAS, KRAS
Adrenergic signaling in cardiomyocytes (hsa04261) NEW5.440.026HRAS, RB1, KRAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.853FGFR3, HRAS, KRAS
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263FGFR3, HRAS, KRAS
NCAM signaling for neurite out-growthR-HSA-3751654.93FGFR3, HRAS, KRAS
Signaling by FGFR3 in diseaseR-HSA-56553328.523FGFR3, HRAS, KRAS
Signaling by InterleukinsR-HSA-4491474.713FGFR3, HRAS, KRAS
Immune SystemR-HSA-1682562.373FGFR3, HRAS, KRAS
Frs2-mediated activationR-HSA-1709685.123FGFR3, HRAS, KRAS
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.623FGFR3, HRAS, KRAS
Cytokine Signaling in Immune systemR-HSA-12802153.743FGFR3, HRAS, KRAS
SOS-mediated signallingR-HSA-1124125.153FGFR3, HRAS, KRAS
IGF1R signaling cascadeR-HSA-24289244.853FGFR3, HRAS, KRAS
Downstream signal transductionR-HSA-1867634.653FGFR3, HRAS, KRAS
IRS-related events triggered by IGF1RR-HSA-24289284.853FGFR3, HRAS, KRAS
Signaling by ERBB4R-HSA-12363944.73FGFR3, HRAS, KRAS
Signaling by Insulin receptorR-HSA-747524.733FGFR3, HRAS, KRAS
Adaptive Immune SystemR-HSA-12802183.193FGFR3, HRAS, KRAS
Developmental BiologyR-HSA-12667383.483FGFR3, HRAS, KRAS
RAF/MAP kinase cascadeR-HSA-56730015.153FGFR3, HRAS, KRAS
Downstream signaling of activated FGFR1R-HSA-56546874.713FGFR3, HRAS, KRAS
MAPK family signaling cascadesR-HSA-56830574.893FGFR3, HRAS, KRAS
Signaling by LeptinR-HSA-25865525.13FGFR3, HRAS, KRAS
Signaling by VEGFR-HSA-1941384.663FGFR3, HRAS, KRAS
Signalling to p38 via RIT and RINR-HSA-1877065.123FGFR3, HRAS, KRAS
FCERI mediated MAPK activationR-HSA-28717964.323FGFR3, HRAS, KRAS
IRS-mediated signallingR-HSA-1123994.873FGFR3, HRAS, KRAS
FRS-mediated FGFR2 signalingR-HSA-56547005.143FGFR3, HRAS, KRAS
FRS-mediated FGFR4 signalingR-HSA-56547125.143FGFR3, HRAS, KRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.143FGFR3, HRAS, KRAS
DiseaseR-HSA-16436853.333FGFR3, HRAS, KRAS
SHC-mediated cascade:FGFR3R-HSA-56547048.813FGFR3, HRAS, KRAS
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593FGFR3, HRAS, KRAS
Downstream signaling of activated FGFR3R-HSA-56547084.713FGFR3, HRAS, KRAS
Insulin receptor signalling cascadeR-HSA-747514.853FGFR3, HRAS, KRAS
Signaling by FGFR4R-HSA-56547434.693FGFR3, HRAS, KRAS
Signaling by FGFR in diseaseR-HSA-12260997.493FGFR3, HRAS, KRAS
Signaling by FGFR3R-HSA-56547414.693FGFR3, HRAS, KRAS
VEGFA-VEGFR2 PathwayR-HSA-44200974.73FGFR3, HRAS, KRAS
GRB2 events in ERBB2 signalingR-HSA-19636405.153FGFR3, HRAS, KRAS
Signaling by FGFRR-HSA-1902364.673FGFR3, HRAS, KRAS
Diseases of signal transductionR-HSA-56632024.893FGFR3, HRAS, KRAS
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.033FGFR3, HRAS, KRAS
Interleukin-2 signalingR-HSA-4519275.053FGFR3, HRAS, KRAS
MAPK1/MAPK3 signalingR-HSA-56849965.113FGFR3, HRAS, KRAS
Interleukin receptor SHC signalingR-HSA-9125265.093FGFR3, HRAS, KRAS
Innate Immune SystemR-HSA-1682493.173FGFR3, HRAS, KRAS
Signaling by SCF-KITR-HSA-14335574.733FGFR3, HRAS, KRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.153FGFR3, HRAS, KRAS
Signaling by PDGFR-HSA-1867974.533FGFR3, HRAS, KRAS
Signalling to RASR-HSA-1670445.083FGFR3, HRAS, KRAS
DAP12 signalingR-HSA-24244914.643FGFR3, HRAS, KRAS
SHC1 events in EGFR signalingR-HSA-1803365.153FGFR3, HRAS, KRAS
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993FGFR3, HRAS, KRAS
Downstream signaling of activated FGFR2R-HSA-56546964.713FGFR3, HRAS, KRAS
SHC1 events in ERBB4 signalingR-HSA-12503475.153FGFR3, HRAS, KRAS
Signaling by EGFRR-HSA-1779294.593FGFR3, HRAS, KRAS
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.513FGFR3, HRAS, KRAS
FRS-mediated FGFR1 signalingR-HSA-56546935.143FGFR3, HRAS, KRAS
Prolonged ERK activation eventsR-HSA-1698935.113FGFR3, HRAS, KRAS
Signalling to ERKsR-HSA-1876875.043FGFR3, HRAS, KRAS
Signalling by NGFR-HSA-1665204.233FGFR3, HRAS, KRAS
Signaling by GPCRR-HSA-3727902.683FGFR3, HRAS, KRAS
Signaling by FGFR2R-HSA-56547384.683FGFR3, HRAS, KRAS
GRB2 events in EGFR signalingR-HSA-1798125.153FGFR3, HRAS, KRAS
Signaling by FGFR1R-HSA-56547364.693FGFR3, HRAS, KRAS
ARMS-mediated activationR-HSA-1709845.123FGFR3, HRAS, KRAS
DAP12 interactionsR-HSA-21721274.563FGFR3, HRAS, KRAS
Downstream signaling of activated FGFR4R-HSA-56547164.713FGFR3, HRAS, KRAS
Signaling by ERBB2R-HSA-12279864.663FGFR3, HRAS, KRAS
Axon guidanceR-HSA-4224753.933FGFR3, HRAS, KRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.073FGFR3, HRAS, KRAS
Signal TransductionR-HSA-1625821.783FGFR3, HRAS, KRAS
p38MAPK eventsR-HSA-1710079.282HRAS, KRAS
MAP2K and MAPK activationR-HSA-56741357.662HRAS, KRAS
Cell surface interactions at the vascular wallR-HSA-2027336.322HRAS, KRAS
RAF activationR-HSA-56730008.342HRAS, KRAS
SHC-mediated cascade:FGFR1R-HSA-56546888.592HRAS, KRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.732HRAS, KRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.082HRAS, KRAS
Signaling by EGFRvIII in CancerR-HSA-56378129.082HRAS, KRAS
Activation of RAS in B cellsR-HSA-116909210.662HRAS, KRAS
Signaling by EGFR in CancerR-HSA-16437138.732HRAS, KRAS
C-type lectin receptors (CLRs)R-HSA-56214816.062HRAS, KRAS
Signaling by FGFR1 in diseaseR-HSA-56553027.812HRAS, KRAS
SHC-mediated cascade:FGFR4R-HSA-56547198.462HRAS, KRAS
SHC-related events triggered by IGF1RR-HSA-24289339.812HRAS, KRAS
SHC-mediated cascade:FGFR2R-HSA-56546998.282HRAS, KRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.732HRAS, KRAS
Negative regulation of MAPK pathwayR-HSA-56752217.662HRAS, KRAS
Regulation of RAS by GAPsR-HSA-56584426.922HRAS, KRAS
CD209 (DC-SIGN) signalingR-HSA-56215758.592HRAS, KRAS
Signaling by FGFR4 in diseaseR-HSA-56552919.522HRAS, KRAS
Tie2 SignalingR-HSA-2109938.812HRAS, KRAS
EGFR Transactivation by GastrinR-HSA-21793929.812HRAS, KRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.232HRAS, KRAS
HemostasisR-HSA-1095823.982HRAS, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.0FGFR3, HRAS, RB1, KRAS
p38MAPK events (R-HSA-171007) -9.280.004HRAS, KRAS
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.018FGFR3, HRAS, RB1, KRAS
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.0FGFR3, HRAS, KRAS
Signaling by Interleukins (R-HSA-449147) -4.710.005FGFR3, HRAS, RB1, KRAS
Signaling by PDGF (R-HSA-186797) -4.530.047FGFR3, HRAS, RB1, KRAS
Interleukin-2 signaling (R-HSA-451927) -5.050.016FGFR3, HRAS, RB1, KRAS
Frs2-mediated activation (R-HSA-170968) -5.120.014FGFR3, HRAS, KRAS
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.002FGFR3, HRAS, RB1, KRAS
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.013FGFR3, HRAS, KRAS
IGF1R signaling cascade (R-HSA-2428924) -4.850.024FGFR3, HRAS, KRAS
Downstream signal transduction (R-HSA-186763) -4.650.006FGFR3, HRAS, RB1, KRAS
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.024FGFR3, HRAS, KRAS
Signaling by ERBB4 (R-HSA-1236394) -4.70.006FGFR3, HRAS, RB1, KRAS
IRS-mediated signalling (R-HSA-112399) -4.870.023FGFR3, HRAS, KRAS
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.014FGFR3, HRAS, KRAS
RAF activation (R-HSA-5673000) -8.340.008HRAS, KRAS
Insulin receptor signalling cascade (R-HSA-74751) -4.850.024FGFR3, HRAS, KRAS
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.033FGFR3, HRAS, RB1, KRAS
MAPK family signaling cascades (R-HSA-5683057) -4.890.022FGFR3, HRAS, KRAS
Signalling by NGF (R-HSA-166520) -4.230.028FGFR3, HRAS, RB1, KRAS
Transport to the Golgi and subsequent modification (R-HSA-948021) NEW7.810.048HRAS, KRAS
Signaling by VEGF (R-HSA-194138) -4.660.036FGFR3, HRAS, KRAS
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.014FGFR3, HRAS, KRAS
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.013FGFR3, HRAS, KRAS
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.0FGFR3, HRAS, KRAS
EGFR Transactivation by Gastrin (R-HSA-2179392) -9.810.001HRAS, KRAS
Signaling by EGFR (R-HSA-177929) -4.590.007FGFR3, HRAS, RB1, KRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.005HRAS, KRAS
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.013FGFR3, HRAS, KRAS
DAP12 interactions (R-HSA-2172127) -4.560.044FGFR3, HRAS, RB1, KRAS
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.013FGFR3, HRAS, KRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.003HRAS, KRAS
SHC-mediated cascade:FGFR3 (R-HSA-5654704) -8.810.0FGFR3, HRAS, KRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.003HRAS, KRAS
Activation of RAS in B cells (R-HSA-1169092) -10.660.0HRAS, KRAS
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.005HRAS, KRAS
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.013FGFR3, HRAS, KRAS
DAP12 signaling (R-HSA-2424491) -4.640.038FGFR3, HRAS, RB1, KRAS
Signaling by FGFR4 (R-HSA-5654743) -4.690.034FGFR3, HRAS, RB1, KRAS
Signaling by FGFR in disease (R-HSA-1226099) -7.490.0FGFR3, HRAS, KRAS
Signaling by FGFR3 (R-HSA-5654741) -4.690.034FGFR3, HRAS, RB1, KRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.024FGFR3, HRAS, KRAS
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.033FGFR3, HRAS, KRAS
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.013FGFR3, HRAS, KRAS
Signaling by FGFR (R-HSA-190236) -4.670.006FGFR3, HRAS, RB1, KRAS
Diseases of signal transduction (R-HSA-5663202) -4.890.004FGFR3, HRAS, RB1, KRAS
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.017FGFR3, HRAS, RB1, KRAS
Signaling by Leptin (R-HSA-2586552) -5.10.014FGFR3, HRAS, KRAS
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.015FGFR3, HRAS, RB1, KRAS
Signaling by SCF-KIT (R-HSA-1433557) -4.730.005FGFR3, HRAS, RB1, KRAS
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.0FGFR3, HRAS, KRAS
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.022FGFR3, HRAS, KRAS
Signalling to RAS (R-HSA-167044) -5.080.015FGFR3, HRAS, KRAS
SHC-related events triggered by IGF1R (R-HSA-2428933) -9.810.001HRAS, KRAS
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.0FGFR3, HRAS, KRAS
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.013FGFR3, HRAS, KRAS
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.002FGFR3, HRAS, RB1, KRAS
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.005FGFR3, HRAS, RB1, KRAS
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.033FGFR3, HRAS, RB1, KRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.005HRAS, KRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.033FGFR3, HRAS, RB1, KRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.049FGFR3, HRAS, RB1, KRAS
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.013FGFR3, HRAS, KRAS
Prolonged ERK activation events (R-HSA-169893) -5.110.014FGFR3, HRAS, KRAS
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.021HRAS, KRAS
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.013FGFR3, HRAS, KRAS
Signaling by FGFR2 (R-HSA-5654738) -4.680.006FGFR3, HRAS, RB1, KRAS
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.013FGFR3, HRAS, KRAS
Signaling by FGFR1 (R-HSA-5654736) -4.690.006FGFR3, HRAS, RB1, KRAS
Signaling by Insulin receptor (R-HSA-74752) -4.730.031FGFR3, HRAS, KRAS
ARMS-mediated activation (R-HSA-170984) -5.120.014FGFR3, HRAS, KRAS
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.014HRAS, KRAS
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.002HRAS, KRAS
SOS-mediated signalling (R-HSA-112412) -5.150.013FGFR3, HRAS, KRAS
Tie2 Signaling (R-HSA-210993) -8.810.004HRAS, KRAS
Signalling to ERKs (R-HSA-187687) -5.040.016FGFR3, HRAS, KRAS
Signaling by ERBB2 (R-HSA-1227986) -4.660.036FGFR3, HRAS, RB1, KRAS
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.007FGFR3, HRAS, KRAS
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.015FGFR3, HRAS, KRAS
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.01FGFR3, HRAS, KRAS
MAP2K and MAPK activation (R-HSA-5674135) -7.660.021HRAS, KRAS
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.054FGFR3, HRAS, RB1, KRAS
heterocyclic compound binding (GO:1901363) 1.064FGFR3, HRAS, RB1, KRAS
protein binding (GO:0005515) 0.464FGFR3, HRAS, RB1, KRAS
binding (GO:0005488) 0.184FGFR3, HRAS, RB1, KRAS
carbohydrate derivative binding (GO:0097367) 2.033FGFR3, HRAS, KRAS
purine ribonucleoside triphosphate binding (GO:0035639) 2.223FGFR3, HRAS, KRAS
nucleotide binding (GO:0000166) 1.963FGFR3, HRAS, KRAS
small molecule binding (GO:0036094) 1.893FGFR3, HRAS, KRAS
catalytic activity (GO:0003824) 1.053FGFR3, HRAS, KRAS
ribonucleotide binding (GO:0032553) 2.193FGFR3, HRAS, KRAS
purine nucleoside binding (GO:0001883) 2.223FGFR3, HRAS, KRAS
ribonucleoside binding (GO:0032549) 2.223FGFR3, HRAS, KRAS
purine ribonucleotide binding (GO:0032555) 2.23FGFR3, HRAS, KRAS
purine nucleotide binding (GO:0017076) 2.193FGFR3, HRAS, KRAS
purine ribonucleoside binding (GO:0032550) 2.223FGFR3, HRAS, KRAS
nucleoside phosphate binding (GO:1901265) 1.963FGFR3, HRAS, KRAS
nucleoside binding (GO:0001882) 2.213FGFR3, HRAS, KRAS
hydrolase activity (GO:0016787) 1.92HRAS, KRAS
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032HRAS, KRAS
guanyl ribonucleotide binding (GO:0032561) 3.732HRAS, KRAS
GTPase activity (GO:0003924) 4.312HRAS, KRAS
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032HRAS, KRAS
nucleoside-triphosphatase activity (GO:0017111) 3.092HRAS, KRAS
pyrophosphatase activity (GO:0016462) 3.042HRAS, KRAS
guanyl nucleotide binding (GO:0019001) 3.732HRAS, KRAS
GTP binding (GO:0005525) 3.782HRAS, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) NEW2.790.041FGFR3, HRAS, RB1, KRAS
diacylglycerol kinase activity (GO:0004143) NEW7.340.007HRAS, KRAS
phosphotransferase activity, alcohol group as acceptor (GO:0016773) NEW3.080.048FGFR3, HRAS, RB1, KRAS
receptor signaling protein activity (GO:0005057) NEW4.760.007FGFR3, HRAS, RB1
NF-kappaB binding (GO:0051059) NEW6.340.01HRAS, KRAS
protein tyrosine kinase activity (GO:0004713) NEW4.540.008FGFR3, HRAS, RB1
protein kinase activity (GO:0004672) NEW3.270.026FGFR3, HRAS, RB1, KRAS
NAD+ kinase activity (GO:0003951) NEW9.050.009HRAS, KRAS
acetylglucosaminyltransferase activity (GO:0008375) NEW5.850.037HRAS, KRAS
transmembrane receptor protein kinase activity (GO:0019199) NEW5.320.001FGFR3, HRAS, RB1
phosphatidylserine binding (GO:0001786) NEW6.240.017HRAS, KRAS
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.364FGFR3, HRAS, RB1, KRAS
regulation of phosphate metabolic process (GO:0019220) 2.354FGFR3, HRAS, RB1, KRAS
positive regulation of metabolic process (GO:0009893) 1.744FGFR3, HRAS, RB1, KRAS
regulation of metabolic process (GO:0019222) 1.024FGFR3, HRAS, RB1, KRAS
positive regulation of cellular metabolic process (GO:0031325) 1.814FGFR3, HRAS, RB1, KRAS
regulation of response to stimulus (GO:0048583) 1.544FGFR3, HRAS, RB1, KRAS
regulation of transferase activity (GO:0051338) 2.884FGFR3, HRAS, RB1, KRAS
regulation of signaling (GO:0023051) 1.724FGFR3, HRAS, RB1, KRAS
intracellular signal transduction (GO:0035556) 2.394FGFR3, HRAS, RB1, KRAS
anatomical structure morphogenesis (GO:0009653) 2.534FGFR3, HRAS, RB1, KRAS
regulation of biological process (GO:0050789) 0.454FGFR3, HRAS, RB1, KRAS
single-organism process (GO:0044699) 0.484FGFR3, HRAS, RB1, KRAS
regulation of primary metabolic process (GO:0080090) 1.084FGFR3, HRAS, RB1, KRAS
regulation of cell communication (GO:0010646) 1.734FGFR3, HRAS, RB1, KRAS
positive regulation of macromolecule metabolic process (GO:0010604) 1.814FGFR3, HRAS, RB1, KRAS
cellular macromolecule metabolic process (GO:0044260) 0.934FGFR3, HRAS, RB1, KRAS
regulation of signal transduction (GO:0009966) 1.844FGFR3, HRAS, RB1, KRAS
cellular developmental process (GO:0048869) 1.824FGFR3, HRAS, RB1, KRAS
regulation of kinase activity (GO:0043549) 3.074FGFR3, HRAS, RB1, KRAS
regulation of protein metabolic process (GO:0051246) 1.934FGFR3, HRAS, RB1, KRAS
organic substance metabolic process (GO:0071704) 0.634FGFR3, HRAS, RB1, KRAS
biological regulation (GO:0065007) 0.394FGFR3, HRAS, RB1, KRAS
positive regulation of molecular function (GO:0044093) 2.234FGFR3, HRAS, RB1, KRAS
regulation of protein modification process (GO:0031399) 2.324FGFR3, HRAS, RB1, KRAS
positive regulation of biological process (GO:0048518) 1.24FGFR3, HRAS, RB1, KRAS
negative regulation of biological process (GO:0048519) 1.334FGFR3, HRAS, RB1, KRAS
regulation of molecular function (GO:0065009) 1.784FGFR3, HRAS, RB1, KRAS
regulation of cell proliferation (GO:0042127) 2.414FGFR3, HRAS, RB1, KRAS
cellular process (GO:0009987) 0.264FGFR3, HRAS, RB1, KRAS
primary metabolic process (GO:0044238) 0.694FGFR3, HRAS, RB1, KRAS
regulation of macromolecule metabolic process (GO:0060255) 1.084FGFR3, HRAS, RB1, KRAS
regulation of cellular metabolic process (GO:0031323) 1.074FGFR3, HRAS, RB1, KRAS
regulation of catalytic activity (GO:0050790) 1.974FGFR3, HRAS, RB1, KRAS
regulation of cellular process (GO:0050794) 0.54FGFR3, HRAS, RB1, KRAS
single-organism developmental process (GO:0044767) 1.494FGFR3, HRAS, RB1, KRAS
single-organism cellular process (GO:0044763) 0.654FGFR3, HRAS, RB1, KRAS
metabolic process (GO:0008152) 0.584FGFR3, HRAS, RB1, KRAS
regulation of protein phosphorylation (GO:0001932) 2.574FGFR3, HRAS, RB1, KRAS
regulation of phosphorylation (GO:0042325) 2.54FGFR3, HRAS, RB1, KRAS
regulation of phosphorus metabolic process (GO:0051174) 2.354FGFR3, HRAS, RB1, KRAS
regulation of cellular protein metabolic process (GO:0032268) 1.994FGFR3, HRAS, RB1, KRAS
cellular metabolic process (GO:0044237) 0.694FGFR3, HRAS, RB1, KRAS
macromolecule metabolic process (GO:0043170) 0.834FGFR3, HRAS, RB1, KRAS
positive regulation of cellular process (GO:0048522) 1.34FGFR3, HRAS, RB1, KRAS
signal transduction (GO:0007165) 1.284FGFR3, HRAS, RB1, KRAS
positive regulation of protein modification process (GO:0031401) 2.73FGFR3, HRAS, KRAS
positive regulation of catalytic activity (GO:0043085) 2.43FGFR3, HRAS, KRAS
positive regulation of kinase activity (GO:0033674) 3.543FGFR3, HRAS, KRAS
MAPK cascade (GO:0000165) 3.913FGFR3, HRAS, KRAS
positive regulation of response to stimulus (GO:0048584) 2.183FGFR3, HRAS, KRAS
regulation of cellular biosynthetic process (GO:0031326) 1.383HRAS, RB1, KRAS
positive regulation of signaling (GO:0023056) 2.413FGFR3, HRAS, KRAS
positive regulation of gene expression (GO:0010628) 2.353HRAS, RB1, KRAS
cell surface receptor signaling pathway (GO:0007166) 2.093FGFR3, HRAS, KRAS
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243FGFR3, HRAS, KRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.543FGFR3, HRAS, KRAS
cell death (GO:0008219) 3.053FGFR3, HRAS, RB1
positive regulation of cell communication (GO:0010647) 2.413FGFR3, HRAS, KRAS
cellular component organization or biogenesis (GO:0071840) 1.223HRAS, RB1, KRAS
regulation of MAPK cascade (GO:0043408) 3.223FGFR3, HRAS, KRAS
cellular protein metabolic process (GO:0044267) 1.633FGFR3, HRAS, KRAS
single-organism metabolic process (GO:0044710) 1.633FGFR3, HRAS, KRAS
regulation of intracellular signal transduction (GO:1902531) 2.313FGFR3, HRAS, KRAS
positive regulation of transferase activity (GO:0051347) 3.313FGFR3, HRAS, KRAS
positive regulation of signal transduction (GO:0009967) 2.53FGFR3, HRAS, KRAS
positive regulation of phosphorus metabolic process (GO:0010562) 2.783FGFR3, HRAS, KRAS
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463HRAS, RB1, KRAS
positive regulation of protein metabolic process (GO:0051247) 2.433FGFR3, HRAS, KRAS
cellular component organization (GO:0016043) 1.243HRAS, RB1, KRAS
positive regulation of immune system process (GO:0002684) 2.963HRAS, RB1, KRAS
regulation of immune system process (GO:0002682) 2.53HRAS, RB1, KRAS
signal transduction by protein phosphorylation (GO:0023014) 3.793FGFR3, HRAS, KRAS
phosphorylation (GO:0016310) 2.633FGFR3, HRAS, KRAS
positive regulation of cellular protein metabolic process (GO:0032270) 2.493FGFR3, HRAS, KRAS
regulation of gene expression (GO:0010468) 1.373HRAS, RB1, KRAS
positive regulation of cell proliferation (GO:0008284) 3.013FGFR3, HRAS, KRAS
protein phosphorylation (GO:0006468) 2.893FGFR3, HRAS, KRAS
apoptotic process (GO:0006915) 3.143FGFR3, HRAS, RB1
positive regulation of phosphate metabolic process (GO:0045937) 2.783FGFR3, HRAS, KRAS
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433HRAS, RB1, KRAS
regulation of protein kinase activity (GO:0045859) 3.153HRAS, RB1, KRAS
regulation of biosynthetic process (GO:0009889) 1.373HRAS, RB1, KRAS
cellular protein modification process (GO:0006464) 1.793FGFR3, HRAS, KRAS
positive regulation of MAPK cascade (GO:0043410) 3.573FGFR3, HRAS, KRAS
programmed cell death (GO:0012501) 3.13FGFR3, HRAS, RB1
macromolecule modification (GO:0043412) 1.733FGFR3, HRAS, KRAS
protein modification process (GO:0036211) 1.793FGFR3, HRAS, KRAS
regulation of nucleic acid-templated transcription (GO:1903506) 1.553HRAS, RB1, KRAS
regulation of RNA biosynthetic process (GO:2001141) 1.553HRAS, RB1, KRAS
positive regulation of intracellular signal transduction (GO:1902533) 2.953FGFR3, HRAS, KRAS
Ras protein signal transduction (GO:0007265) 4.763HRAS, RB1, KRAS
small GTPase mediated signal transduction (GO:0007264) 3.853HRAS, RB1, KRAS
multi-organism process (GO:0051704) 2.653HRAS, RB1, KRAS
positive regulation of phosphorylation (GO:0042327) 2.93FGFR3, HRAS, KRAS
protein metabolic process (GO:0019538) 1.453FGFR3, HRAS, KRAS
response to stimulus (GO:0050896) 1.223HRAS, RB1, KRAS
anatomical structure development (GO:0048856) 1.583FGFR3, RB1, KRAS
regulation of transcription, DNA-templated (GO:0006355) 1.563HRAS, RB1, KRAS
phosphate-containing compound metabolic process (GO:0006796) 2.163FGFR3, HRAS, KRAS
regulation of macromolecule biosynthetic process (GO:0010556) 1.433HRAS, RB1, KRAS
phosphorus metabolic process (GO:0006793) 2.153FGFR3, HRAS, KRAS
cell differentiation (GO:0030154) 2.143FGFR3, RB1, KRAS
regulation of RNA metabolic process (GO:0051252) 1.523HRAS, RB1, KRAS
positive regulation of protein phosphorylation (GO:0001934) 2.953FGFR3, HRAS, KRAS
negative regulation of cellular process (GO:0048523) 1.413HRAS, RB1, KRAS
regulation of nitrogen compound metabolic process (GO:0051171) 1.363HRAS, RB1, KRAS
modulation of synaptic transmission (GO:0050804) 4.092HRAS, KRAS
behavior (GO:0007610) 3.472HRAS, KRAS
positive regulation of defense response (GO:0031349) 3.832HRAS, KRAS
regulation of neuron apoptotic process (GO:0043523) 4.472HRAS, KRAS
negative regulation of neuron apoptotic process (GO:0043524) 4.822HRAS, KRAS
regulation of defense response (GO:0031347) 3.112HRAS, KRAS
cellular response to stimulus (GO:0051716) 1.972HRAS, RB1
negative regulation of cell cycle (GO:0045786) 3.672HRAS, RB1
negative regulation of molecular function (GO:0044092) 2.742HRAS, RB1
positive regulation of small GTPase mediated signal transduction (GO:0051057) 6.042HRAS, KRAS
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082HRAS, KRAS
social behavior (GO:0035176) 5.92HRAS, KRAS
negative regulation of cell death (GO:0060548) 2.952HRAS, KRAS
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832RB1, KRAS
epidermal growth factor receptor signaling pathway (GO:0007173) 5.722HRAS, KRAS
intraspecies interaction between organisms (GO:0051703) 5.92HRAS, KRAS
neuron projection guidance (GO:0097485) 4.432HRAS, KRAS
multi-organism behavior (GO:0051705) 5.62HRAS, KRAS
single organism signaling (GO:0044700) 3.252FGFR3, KRAS
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062HRAS, KRAS
single-multicellular organism process (GO:0044707) 1.782FGFR3, KRAS
cell motility (GO:0048870) 3.022HRAS, KRAS
positive regulation of organelle organization (GO:0010638) 3.382HRAS, RB1
immune system process (GO:0002376) 2.292HRAS, KRAS
positive regulation of immune response (GO:0050778) 3.42HRAS, KRAS
muscle cell differentiation (GO:0042692) 5.092RB1, KRAS
negative regulation of metabolic process (GO:0009892) 1.932HRAS, RB1
positive regulation of biosynthetic process (GO:0009891) 2.292HRAS, RB1
movement of cell or subcellular component (GO:0006928) 2.612HRAS, KRAS
regulation of synaptic plasticity (GO:0048167) 4.782HRAS, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062HRAS, KRAS
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582HRAS, KRAS
regulation of apoptotic process (GO:0042981) 2.52HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168) 5.842HRAS, KRAS
organic substance biosynthetic process (GO:1901576) 1.342FGFR3, RB1
regulation of mitotic cell cycle (GO:0007346) 3.712HRAS, RB1
immune response-regulating signaling pathway (GO:0002764) 3.722HRAS, KRAS
positive regulation of hydrolase activity (GO:0051345) 2.912FGFR3, HRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962HRAS, KRAS
positive regulation of RNA metabolic process (GO:0051254) 2.512HRAS, RB1
cell migration (GO:0016477) 3.122HRAS, KRAS
positive regulation of cellular component organization (GO:0051130) 2.682HRAS, RB1
organ morphogenesis (GO:0009887) 3.552FGFR3, HRAS
regulation of developmental process (GO:0050793) 2.12FGFR3, RB1
cell cycle arrest (GO:0007050) 4.692HRAS, RB1
regulation of multicellular organismal process (GO:0051239) 1.872HRAS, RB1
negative regulation of macromolecule metabolic process (GO:0010605) 2.012HRAS, RB1
regulation of neuron death (GO:1901214) 4.192HRAS, KRAS
negative regulation of neuron death (GO:1901215) 4.572HRAS, KRAS
regulation of hydrolase activity (GO:0051336) 2.532FGFR3, HRAS
regulation of lipid kinase activity (GO:0043550) 5.842FGFR3, RB1
immune response-activating signal transduction (GO:0002757) 3.82HRAS, KRAS
Fc receptor signaling pathway (GO:0038093) 4.452HRAS, KRAS
regulation of response to stress (GO:0080134) 2.532HRAS, KRAS
innate immune response-activating signal transduction (GO:0002758) 4.452HRAS, KRAS
activation of innate immune response (GO:0002218) 4.412HRAS, KRAS
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392HRAS, RB1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242HRAS, RB1
regulation of organelle organization (GO:0033043) 2.722HRAS, RB1
regulation of synapse structure or activity (GO:0050803) 4.772HRAS, KRAS
regulation of Ras protein signal transduction (GO:0046578) 4.492HRAS, KRAS
positive regulation of Ras protein signal transduction (GO:0046579) 6.22HRAS, KRAS
regulation of cellular component organization (GO:0051128) 2.012HRAS, RB1
positive regulation of MAP kinase activity (GO:0043406) 4.392HRAS, KRAS
regulation of MAP kinase activity (GO:0043405) 3.952HRAS, KRAS
signaling (GO:0023052) 3.252FGFR3, KRAS
ERBB signaling pathway (GO:0038127) 5.362HRAS, KRAS
cell communication (GO:0007154) 3.042FGFR3, KRAS
axon guidance (GO:0007411) 4.442HRAS, KRAS
ERBB2 signaling pathway (GO:0038128) 6.092HRAS, KRAS
regulation of GTPase activity (GO:0043087) 3.212FGFR3, HRAS
negative regulation of catalytic activity (GO:0043086) 3.02HRAS, RB1
positive regulation of multicellular organismal process (GO:0051240) 2.492HRAS, RB1
regulation of long-term neuronal synaptic plasticity (GO:0048169) 6.552HRAS, KRAS
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.072HRAS, KRAS
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.092HRAS, KRAS
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562HRAS, RB1
negative regulation of cell proliferation (GO:0008285) 3.262HRAS, RB1
multicellular organismal process (GO:0032501) 1.452FGFR3, KRAS
cell proliferation (GO:0008283) 3.232FGFR3, HRAS
regulation of cell differentiation (GO:0045595) 2.422RB1, KRAS
Fc-epsilon receptor signaling pathway (GO:0038095) 4.842HRAS, KRAS
positive regulation of transcription, DNA-templated (GO:0045893) 2.562HRAS, RB1
regulation of localization (GO:0032879) 1.942HRAS, RB1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352HRAS, RB1
regulation of immune response (GO:0050776) 2.982HRAS, KRAS
regulation of epithelial cell proliferation (GO:0050678) 4.062HRAS, RB1
regulation of biological quality (GO:0065008) 1.682HRAS, KRAS
negative regulation of gene expression (GO:0010629) 2.482HRAS, RB1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542HRAS, RB1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812HRAS, RB1
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562FGFR3, HRAS
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232FGFR3, HRAS
positive regulation of cellular biosynthetic process (GO:0031328) 2.32HRAS, RB1
macromolecular complex subunit organization (GO:0043933) 2.142HRAS, RB1
apoptotic signaling pathway (GO:0097190) 4.122FGFR3, HRAS
mitotic cell cycle process (GO:1903047) 3.122HRAS, RB1
leukocyte migration (GO:0050900) 4.192HRAS, KRAS
cell cycle process (GO:0022402) 2.752HRAS, RB1
striated muscle cell differentiation (GO:0051146) 5.692RB1, KRAS
regulation of cell death (GO:0010941) 2.432HRAS, KRAS
developmental maturation (GO:0021700) 4.72FGFR3, RB1
positive regulation of protein kinase activity (GO:0045860) 3.612HRAS, KRAS
regulation of programmed cell death (GO:0043067) 2.492HRAS, KRAS
negative regulation of apoptotic process (GO:0043066) 3.042HRAS, KRAS
negative regulation of programmed cell death (GO:0043069) 3.022HRAS, KRAS
negative regulation of mitotic cell cycle (GO:0045930) 4.452HRAS, RB1
positive regulation of innate immune response (GO:0045089) 4.222HRAS, KRAS
regulation of innate immune response (GO:0045088) 3.862HRAS, KRAS
regulation of lipid metabolic process (GO:0019216) 4.082FGFR3, RB1
biosynthetic process (GO:0009058) 1.322FGFR3, RB1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292HRAS, RB1
cell-cell signaling (GO:0007267) 3.352FGFR3, KRAS
response to chemical (GO:0042221) 1.982RB1, KRAS
localization (GO:0051179) 1.42HRAS, RB1
positive regulation of GTPase activity (GO:0043547) 3.282FGFR3, HRAS
locomotion (GO:0040011) 2.912HRAS, KRAS
cell cycle checkpoint (GO:0000075) 4.792HRAS, RB1
regulation of cell cycle (GO:0051726) 2.932HRAS, RB1
regulation of cellular component biogenesis (GO:0044087) 3.082HRAS, RB1
activation of immune response (GO:0002253) 3.672HRAS, KRAS
cellular biosynthetic process (GO:0044249) 1.372FGFR3, RB1
mitotic cell cycle checkpoint (GO:0007093) 5.312HRAS, RB1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of cell proliferation (GO:0042127) -2.410.02FGFR3, HRAS, RB1, KRAS
regulation of smoothened signaling pathway (GO:0008589) NEW5.620.047FGFR3, RB1
visual behavior (GO:0007632) NEW5.820.026HRAS, KRAS
positive regulation of kinase activity (GO:0033674) -3.540.046FGFR3, HRAS, KRAS
regulation of cell cycle process (GO:0010564) NEW3.50.047FGFR3, HRAS, RB1
cell differentiation (GO:0030154) -2.140.043FGFR3, HRAS, RB1, KRAS
apoptotic signaling pathway (GO:0097190) -4.120.013FGFR3, HRAS, RB1, KRAS
negative regulation of epithelial cell proliferation (GO:0050680) NEW4.980.0FGFR3, HRAS, RB1, KRAS
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.008FGFR3, HRAS, KRAS
negative regulation of cell cycle process (GO:0010948) NEW4.370.007FGFR3, HRAS, RB1
regulation of neuron apoptotic process (GO:0043523) -4.470.003FGFR3, HRAS, KRAS
regulation of Rac protein signal transduction (GO:0035020) NEW7.240.01HRAS, KRAS
ERBB signaling pathway (GO:0038127) -5.360.003FGFR3, HRAS, KRAS
positive regulation of Rac protein signal transduction (GO:0035022) NEW8.630.0HRAS, KRAS
striated muscle cell differentiation (GO:0051146) -5.690.004HRAS, RB1, KRAS
cellular response to insulin stimulus (GO:0032869) NEW5.290.001FGFR3, HRAS, RB1, KRAS
response to insulin (GO:0032868) NEW4.720.006FGFR3, HRAS, RB1, KRAS
intracellular signal transduction (GO:0035556) -2.390.033FGFR3, HRAS, RB1, KRAS
anatomical structure morphogenesis (GO:0009653) -2.530.016FGFR3, HRAS, RB1, KRAS
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.048FGFR3, HRAS, KRAS
regulation of neuronal synaptic plasticity (GO:0048168) -5.840.024HRAS, KRAS
signal transduction by phosphorylation (GO:0023014) -3.790.002FGFR3, HRAS, RB1, KRAS
morphogenesis of an epithelium (GO:0002009) NEW4.080.014FGFR3, HRAS, RB1, KRAS
regulation of mitotic cell cycle (GO:0007346) -3.710.025FGFR3, HRAS, RB1, KRAS
negative regulation of cell cycle (GO:0045786) -3.670.005FGFR3, HRAS, RB1, KRAS
cellular response to peptide hormone stimulus (GO:0071375) NEW4.630.007FGFR3, HRAS, RB1, KRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) -6.550.008HRAS, KRAS
cellular response to organonitrogen compound (GO:0071417) NEW3.870.048FGFR3, HRAS, RB1, KRAS
regulation of kinase activity (GO:0043549) -3.070.002FGFR3, HRAS, RB1, KRAS
MAPK cascade (GO:0000165) -3.910.002FGFR3, HRAS, RB1, KRAS
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.003FGFR3, HRAS, KRAS
visual learning (GO:0008542) NEW5.920.021HRAS, KRAS
epithelial tube branching involved in lung morphogenesis (GO:0060441) NEW6.90.034HRAS, KRAS
positive regulation of protein modification by small protein conjugation or removal (GO:1903322) NEW4.480.026FGFR3, HRAS, KRAS
regulation of cellular protein metabolic process (GO:0032268) -1.990.035FGFR3, HRAS, RB1, KRAS
response to peptide hormone (GO:0043434) NEW4.060.02FGFR3, HRAS, RB1, KRAS
negative regulation of immune system process (GO:0002683) NEW3.850.007FGFR3, HRAS, RB1, KRAS
tissue morphogenesis (GO:0048729) NEW3.870.019FGFR3, HRAS, RB1, KRAS
regulation of protein modification process (GO:0031399) -2.320.014FGFR3, HRAS, RB1, KRAS
negative regulation of developmental growth (GO:0048640) NEW5.250.002FGFR3, HRAS, KRAS
regulation of immune system process (GO:0002682) -2.50.018FGFR3, HRAS, RB1, KRAS
endochondral bone growth (GO:0003416) NEW7.940.004FGFR3, RB1
regulation of mitosis (GO:0007088) NEW4.830.032FGFR3, HRAS, RB1
positive regulation of small GTPase mediated signal transduction (GO:0051057) -6.040.014HRAS, KRAS
activation of MAPKK activity (GO:0000186) NEW5.740.044HRAS, KRAS
neurotrophin signaling pathway (GO:0038179) NEW6.550.009FGFR3, HRAS, KRAS
positive regulation of protein ubiquitination (GO:0031398) NEW4.550.019FGFR3, HRAS, KRAS
social behavior (GO:0035176) -5.90.02HRAS, KRAS
epithelial cell differentiation (GO:0030855) NEW3.980.016FGFR3, HRAS, RB1, KRAS
insulin receptor signaling pathway (GO:0008286) NEW5.330.001FGFR3, HRAS, KRAS
negative regulation of smoothened signaling pathway (GO:0045879) NEW6.550.009FGFR3, RB1
positive regulation of Ras protein signal transduction (GO:0046579) -6.20.01HRAS, KRAS
positive regulation of MAPK cascade (GO:0043410) -3.570.02FGFR3, HRAS, KRAS
cellular response to hormone stimulus (GO:0032870) NEW3.990.042FGFR3, HRAS, KRAS
Fc-epsilon receptor signaling pathway (GO:0038095) -4.840.01FGFR3, HRAS, KRAS
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.003FGFR3, HRAS, KRAS
somatic stem cell maintenance (GO:0035019) NEW5.520.004FGFR3, RB1, KRAS
Ras protein signal transduction (GO:0007265) -4.760.001HRAS, RB1, KRAS
small GTPase mediated signal transduction (GO:0007264) -3.850.042HRAS, RB1, KRAS
developmental growth involved in morphogenesis (GO:0060560) NEW5.150.018FGFR3, HRAS, RB1
growth (GO:0040007) NEW3.80.042FGFR3, HRAS, RB1, KRAS
regulation of phosphorylation (GO:0042325) -2.50.011FGFR3, HRAS, RB1, KRAS
regulation of lipid kinase activity (GO:0043550) -5.840.021FGFR3, RB1
muscle cell differentiation (GO:0042692) -5.090.001HRAS, RB1, KRAS
regulation of epithelial cell proliferation (GO:0050678) -4.060.012FGFR3, HRAS, RB1, KRAS
Fc receptor signaling pathway (GO:0038093) -4.450.018FGFR3, HRAS, KRAS
regulation of cell size (GO:0008361) NEW5.420.0HRAS, RB1, KRAS
intraspecies interaction between organisms (GO:0051703) -5.90.02HRAS, KRAS
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) NEW5.260.011FGFR3, HRAS, RB1
cellular response to nitrogen compound (GO:1901699) NEW3.790.036FGFR3, HRAS, KRAS
regulation of cell differentiation (GO:0045595) -2.420.016FGFR3, HRAS, RB1, KRAS
regulation of transferase activity (GO:0051338) -2.880.003FGFR3, HRAS, RB1, KRAS
regulation of synaptic transmission, GABAergic (GO:0032228) NEW6.360.012HRAS, KRAS
associative learning (GO:0008306) NEW5.440.047HRAS, KRAS
response to peptide (GO:1901652) NEW3.940.03FGFR3, HRAS, RB1, KRAS
cellular response to peptide (GO:1901653) NEW4.520.009FGFR3, HRAS, RB1, KRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.039FGFR3, HRAS, KRAS
response to fibroblast growth factor (GO:0071774) NEW6.170.003FGFR3, HRAS, KRAS
regulation of protein phosphorylation (GO:0001932) -2.570.005FGFR3, HRAS, RB1, KRAS
positive regulation of myeloid cell differentiation (GO:0045639) NEW5.330.01HRAS, RB1, KRAS
regulation of neuron death (GO:1901214) -4.190.004FGFR3, HRAS, KRAS
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.64FGFR3, HRAS, RB1, KRAS
cell part (GO:0044464) 0.114FGFR3, HRAS, RB1, KRAS
intracellular organelle (GO:0043229) 0.514FGFR3, HRAS, RB1, KRAS
intracellular part (GO:0044424) 0.284FGFR3, HRAS, RB1, KRAS
membrane-bounded organelle (GO:0043227) 0.474FGFR3, HRAS, RB1, KRAS
organelle (GO:0043226) 0.44FGFR3, HRAS, RB1, KRAS
cytoplasm (GO:0005737) 1.013FGFR3, HRAS, KRAS
cytoplasmic part (GO:0044444) 0.823FGFR3, HRAS, KRAS
membrane (GO:0016020) 0.683FGFR3, HRAS, KRAS
nucleus (GO:0005634) 1.073FGFR3, HRAS, RB1
plasma membrane (GO:0005886) 1.393FGFR3, HRAS, KRAS
Golgi apparatus (GO:0005794) 2.72FGFR3, HRAS
cytosol (GO:0005829) 1.682HRAS, KRAS
anchoring junction (GO:0070161) 3.612FGFR3, KRAS
organelle part (GO:0044422) 0.792HRAS, RB1
intracellular (GO:0005622) 2.372HRAS, KRAS
intracellular organelle part (GO:0044446) 0.812HRAS, RB1
adherens junction (GO:0005912) 3.662FGFR3, KRAS
membrane part (GO:0044425) 0.952FGFR3, KRAS
cell-substrate adherens junction (GO:0005924) 3.832FGFR3, KRAS
focal adhesion (GO:0005925) 3.832FGFR3, KRAS
plasma membrane part (GO:0044459) 1.952FGFR3, KRAS
cell junction (GO:0030054) 2.752FGFR3, KRAS
cell-substrate junction (GO:0030055) 3.822FGFR3, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
cytoplasmic membrane-bounded vesicle (GO:0016023) NEW3.120.029FGFR3, HRAS, RB1, KRAS
perinuclear region of cytoplasm (GO:0048471) NEW3.350.023FGFR3, HRAS, RB1, KRAS
cytosolic part (GO:0044445) NEW4.340.004HRAS, RB1, KRAS
extracellular matrix (GO:0031012) NEW3.810.001FGFR3, HRAS, RB1, KRAS