Gene table of NFKBIA : NFKB inhibitor alpha

Gene-disease associations table

Disease IDDisease nameSource of annotation with NFKBIAOMIM linkNumber of associated genesgenes
612132ECTODERMAL DYSPLASIA, ANHIDROTIC, WITH T-CELL IMMUNODEFICIENCY, AUTOSOMAL DOMINANTOMIM, HUMSAVAR link to OMIM 1NFKBIA

Download the gene annotation in CSV format

Annotation of the gene NFKBIA

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Shigellosishsa051316.74
Legionellosishsa051346.88
cAMP signaling pathwayhsa040245.05
Prostate cancerhsa052156.11
Neurotrophin signaling pathwayhsa047225.78
Osteoclast differentiationhsa043805.64
NF-kappa B signaling pathwayhsa040646.21
Chemokine signaling pathwayhsa040625.19
Adipocytokine signaling pathwayhsa049206.6
Chagas disease (American trypanosomiasis)hsa051425.99
Leishmaniasishsa051406.32
Herpes simplex infectionhsa051685.08
Epstein-Barr virus infectionhsa051694.97
Toxoplasmosishsa051455.71
Influenza Ahsa051645.21
Apoptosishsa042106.23
HTLV-I infectionhsa051664.59
Hepatitis Chsa051605.68
Hepatitis Bhsa051615.52
Measleshsa051625.6
Epithelial cell signaling in Helicobacter pylori infectionhsa051206.58
Toll-like receptor signaling pathwayhsa046206.0
NOD-like receptor signaling pathwayhsa046216.88
Viral carcinogenesishsa052035.08
Pathways in cancerhsa052003.98
T cell receptor signaling pathwayhsa046606.01
B cell receptor signaling pathwayhsa046626.52
RIG-I-like receptor signaling pathwayhsa046226.62
Chronic myeloid leukemiahsa052206.48
TNF signaling pathwayhsa046685.96
Cytosolic DNA-sensing pathwayhsa046236.79
Small cell lung cancerhsa052226.17
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
C-type lectin receptors (CLRs)R-HSA-56214816.06
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Immune SystemR-HSA-1682562.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
Diseases associated with the TLR signaling cascadeR-HSA-56023588.34
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Adaptive Immune SystemR-HSA-12802183.19
DiseaseR-HSA-16436853.33
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Signalling by NGFR-HSA-1665204.23
IkBA variant leads to EDA-IDR-HSA-560302910.18
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Toll-Like Receptors CascadesR-HSA-1688985.91
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
NF-kB is activated and signals survivalR-HSA-2095609.28
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.28
Activation of NF-kappaB in B cellsR-HSA-11690916.94
TCR signalingR-HSA-2024036.64
TRAF6 mediated NF-kB activationR-HSA-9335428.4
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Downstream TCR signalingR-HSA-2024247.01
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Innate Immune SystemR-HSA-1682493.17
p75NTR signals via NF-kBR-HSA-1936398.98
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.59
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
Diseases of Immune SystemR-HSA-52602718.34
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)R-HSA-56030279.98
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Activated TLR4 signallingR-HSA-1660546.27
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Signal TransductionR-HSA-1625821.78
FCERI mediated NF-kB activationR-HSA-28718375.11
Associated GO terms for Molecular function
GO termGO IDGO IC
enzyme bindingGO:00198992.27
ubiquitin protein ligase bindingGO:00316254.17
ubiquitin-like protein ligase bindingGO:00443894.15
signal sequence bindingGO:00050486.07
nuclear localization sequence bindingGO:00081396.69
amide bindingGO:00332184.14
transcription factor bindingGO:00081343.46
NF-kappaB bindingGO:00510596.34
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
protein bindingGO:00055150.46
heat shock protein bindingGO:00310725.24
protein complex bindingGO:00324033.09
peptide bindingGO:00422774.22
identical protein bindingGO:00428022.63