Disease table of ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL OMIM ID: 502500

Gene-disease associations table

GeneAssociated with ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MT-ND1HUMSAVARHGNC linkMT6500008, 535000, 540000, 500001, 502500, 252010
MT-ND2HUMSAVARHGNC linkMT2535000, 502500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MT-ND1MT-ND2Yesbinding43NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MT-ND1MT-ND2YesRespiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial43NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.492MT-ND2, MT-ND1
Oxidative phosphorylationhsa001905.692MT-ND2, MT-ND1
Parkinson's diseasehsa050125.592MT-ND2, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
Alzheimer's disease (hsa05010) NEW5.340.012MT-ND2, MT-ND1
Neurodegenerative diseasesNEW4.270.024MT-ND2, MT-ND1
Energy metabolismNEW5.420.007MT-ND2, MT-ND1
Parkinson's disease (hsa05012) -5.590.007MT-ND2, MT-ND1
Oxidative phosphorylation (hsa00190) -5.690.003MT-ND2, MT-ND1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.342MT-ND2, MT-ND1
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.712MT-ND2, MT-ND1
Respiratory electron transportR-HSA-6111056.442MT-ND2, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.122MT-ND2, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.002MT-ND2, MT-ND1
Respiratory electron transport (R-HSA-611105) -6.440.001MT-ND2, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.001MT-ND2, MT-ND1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
oxidoreductase activity, acting on NAD(P)H (GO:0016651) 5.132MT-ND2, MT-ND1
NADH dehydrogenase (ubiquinone) activity (GO:0008137) 5.932MT-ND2, MT-ND1
catalytic activity (GO:0003824) 1.052MT-ND2, MT-ND1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) 5.662MT-ND2, MT-ND1
binding (GO:0005488) 0.182MT-ND2, MT-ND1
protein binding (GO:0005515) 0.462MT-ND2, MT-ND1
oxidoreductase activity (GO:0016491) 3.122MT-ND2, MT-ND1
NADH dehydrogenase activity (GO:0003954) 5.932MT-ND2, MT-ND1
NADH dehydrogenase (quinone) activity (GO:0050136) 5.932MT-ND2, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity, acting on NAD(P)H (GO:0016651) -5.130.001MT-ND2, MT-ND1
NADH dehydrogenase (ubiquinone) activity (GO:0008137) -5.930.0MT-ND2, MT-ND1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) -5.660.0MT-ND2, MT-ND1
NADH dehydrogenase (quinone) activity (GO:0050136) -5.930.0MT-ND2, MT-ND1
NADH dehydrogenase activity (GO:0003954) -5.930.0MT-ND2, MT-ND1
oxidoreductase activity (GO:0016491) -3.120.02MT-ND2, MT-ND1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular component assembly (GO:0022607) 2.142MT-ND2, MT-ND1
protein complex biogenesis (GO:0070271) 5.372MT-ND2, MT-ND1
macromolecular complex subunit organization (GO:0043933) 2.142MT-ND2, MT-ND1
cellular macromolecular complex assembly (GO:0034622) 3.182MT-ND2, MT-ND1
generation of precursor metabolites and energy (GO:0006091) 4.072MT-ND2, MT-ND1
single-organism process (GO:0044699) 0.482MT-ND2, MT-ND1
single-organism metabolic process (GO:0044710) 1.632MT-ND2, MT-ND1
protein complex subunit organization (GO:0071822) 2.62MT-ND2, MT-ND1
mitochondrial respiratory chain complex I assembly (GO:0032981) 5.62MT-ND2, MT-ND1
NADH dehydrogenase complex assembly (GO:0010257) 5.62MT-ND2, MT-ND1
cellular component organization (GO:0016043) 1.242MT-ND2, MT-ND1
macromolecular complex assembly (GO:0065003) 2.552MT-ND2, MT-ND1
electron transport chain (GO:0022900) 5.092MT-ND2, MT-ND1
cellular component organization or biogenesis (GO:0071840) 1.222MT-ND2, MT-ND1
respiratory electron transport chain (GO:0022904) 5.112MT-ND2, MT-ND1
mitochondrial respiratory chain complex assembly (GO:0033108) 5.312MT-ND2, MT-ND1
cellular process (GO:0009987) 0.262MT-ND2, MT-ND1
protein complex assembly (GO:0006461) 2.782MT-ND2, MT-ND1
single-organism cellular process (GO:0044763) 0.652MT-ND2, MT-ND1
metabolic process (GO:0008152) 0.582MT-ND2, MT-ND1
cellular protein complex assembly (GO:0043623) 3.92MT-ND2, MT-ND1
oxidation-reduction process (GO:0055114) 2.912MT-ND2, MT-ND1
mitochondrial respiratory chain complex I biogenesis (GO:0097031) 5.62MT-ND2, MT-ND1
cellular metabolic process (GO:0044237) 0.692MT-ND2, MT-ND1
mitochondrial electron transport, NADH to ubiquinone (GO:0006120) 5.842MT-ND2, MT-ND1
cellular component biogenesis (GO:0044085) 4.462MT-ND2, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
mitochondrial electron transport, NADH to ubiquinone (GO:0006120) -5.840.0MT-ND2, MT-ND1
generation of precursor metabolites and energy (GO:0006091) -4.070.006MT-ND2, MT-ND1
electron transport chain (GO:0022900) -5.090.001MT-ND2, MT-ND1
oxidation-reduction process (GO:0055114) -2.910.047MT-ND2, MT-ND1
respiratory electron transport chain (GO:0022904) -5.110.004MT-ND2, MT-ND1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.112MT-ND2, MT-ND1
oxidoreductase complex (GO:1990204) 5.192MT-ND2, MT-ND1
intracellular organelle (GO:0043229) 0.512MT-ND2, MT-ND1
membrane-bounded organelle (GO:0043227) 0.472MT-ND2, MT-ND1
organelle (GO:0043226) 0.42MT-ND2, MT-ND1
intrinsic component of membrane (GO:0031224) 1.132MT-ND2, MT-ND1
organelle membrane (GO:0031090) 1.972MT-ND2, MT-ND1
mitochondrial inner membrane (GO:0005743) 3.652MT-ND2, MT-ND1
integral component of membrane (GO:0016021) 1.142MT-ND2, MT-ND1
membrane (GO:0016020) 0.682MT-ND2, MT-ND1
respiratory chain complex (GO:0098803) 5.472MT-ND2, MT-ND1
mitochondrion (GO:0005739) 2.422MT-ND2, MT-ND1
inner mitochondrial membrane protein complex (GO:0098800) 5.012MT-ND2, MT-ND1
mitochondrial membrane part (GO:0044455) 4.542MT-ND2, MT-ND1
neuron part (GO:0097458) 2.642MT-ND2, MT-ND1
mitochondrial respiratory chain complex I (GO:0005747) 5.912MT-ND2, MT-ND1
catalytic complex (GO:1902494) 2.92MT-ND2, MT-ND1
mitochondrial membrane (GO:0031966) 3.312MT-ND2, MT-ND1
protein complex (GO:0043234) 1.512MT-ND2, MT-ND1
respiratory chain complex I (GO:0045271) 5.912MT-ND2, MT-ND1
macromolecular complex (GO:0032991) 1.352MT-ND2, MT-ND1
intracellular membrane-bounded organelle (GO:0043231) 0.62MT-ND2, MT-ND1
NADH dehydrogenase complex (GO:0030964) 5.912MT-ND2, MT-ND1
organelle inner membrane (GO:0019866) 3.562MT-ND2, MT-ND1
intracellular organelle part (GO:0044446) 0.812MT-ND2, MT-ND1
membrane protein complex (GO:0098796) 2.842MT-ND2, MT-ND1
cytoplasmic part (GO:0044444) 0.822MT-ND2, MT-ND1
mitochondrial part (GO:0044429) 2.922MT-ND2, MT-ND1
intracellular part (GO:0044424) 0.282MT-ND2, MT-ND1
membrane part (GO:0044425) 0.952MT-ND2, MT-ND1
respiratory chain (GO:0070469) 5.512MT-ND2, MT-ND1
organelle part (GO:0044422) 0.792MT-ND2, MT-ND1
mitochondrial protein complex (GO:0098798) 4.782MT-ND2, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
respiratory chain complex I (GO:0045271) -5.910.0MT-ND2, MT-ND1
catalytic complex (GO:1902494) -2.90.037MT-ND2, MT-ND1
NADH dehydrogenase complex (GO:0030964) -5.910.0MT-ND2, MT-ND1
organelle inner membrane (GO:0019866) -3.560.035MT-ND2, MT-ND1
oxidoreductase complex (GO:1990204) -5.190.001MT-ND2, MT-ND1
mitochondrial membrane part (GO:0044455) -4.540.002MT-ND2, MT-ND1
mitochondrial inner membrane (GO:0005743) -3.650.007MT-ND2, MT-ND1
mitochondrial respiratory chain complex I (GO:0005747) -5.910.0MT-ND2, MT-ND1
mitochondrial membrane (GO:0031966) -3.310.014MT-ND2, MT-ND1
mitochondrial part (GO:0044429) -2.920.042MT-ND2, MT-ND1