Disease table of LEBER OPTIC ATROPHY AND DYSTONIA OMIM ID: 500001

Gene-disease associations table

Gene	Associated with LEBER OPTIC ATROPHY AND DYSTONIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MT-ND1	OMIM	HGNC link	MT	6	500008, 535000, 540000, 500001, 502500, 252010
MT-ND3	OMIM	HGNC link	MT	3	256000, 252010, 500001
MT-ND4	OMIM, HUMSAVAR	HGNC link	MT	3	540000, 500001, 535000
MT-ND6	OMIM, HUMSAVAR	HGNC link	MT	5	535000, 553000, 540000, 252010, 500001

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND3	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	MT-ND4	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND3	MT-ND4	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFB2, MT-ND5, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND3	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND4	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND3	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	43	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, MT-ND2, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND4	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND1	MT-ND6	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND3	MT-ND4	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND3	MT-ND6	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-ND6	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Oxidative phosphorylation	hsa00190	5.69	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Parkinson's disease	hsa05012	5.59	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Neurodegenerative diseases	NEW	4.27	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Global and overview maps	NEW	2.47	0.01	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Metabolism	NEW	2.06	0.03	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Oxidative phosphorylation (hsa00190)	-	5.69	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Metabolic pathways (hsa01100)	-	2.49	0.009	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Energy metabolism	NEW	5.42	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Parkinson's disease (hsa05012)	-	5.59	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Respiratory electron transport	R-HSA-611105	6.44	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Metabolism	R-HSA-1430728	2.34	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Metabolism (R-HSA-1430728)	-	2.34	0.008	MT-ND6, MT-ND4, MT-ND3, MT-ND1
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517)	-	5.71	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Respiratory electron transport (R-HSA-611105)	-	6.44	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200)	-	6.12	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	5.66	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	5.93	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
catalytic activity (GO:0003824)	1.05	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	5.13	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase activity (GO:0016491)	3.12	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase activity (GO:0003954)	5.93	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase (quinone) activity (GO:0050136)	5.93	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
binding (GO:0005488)	0.18	2	MT-ND3, MT-ND1
protein binding (GO:0005515)	0.46	2	MT-ND3, MT-ND1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	-	5.66	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	-	5.13	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase activity (GO:0016491)	-	3.12	0.001	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase activity (GO:0003954)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase (quinone) activity (GO:0050136)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular component assembly (GO:0022607)	2.14	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
protein complex biogenesis (GO:0070271)	5.37	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
macromolecular complex subunit organization (GO:0043933)	2.14	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular macromolecular complex assembly (GO:0034622)	3.18	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
generation of precursor metabolites and energy (GO:0006091)	4.07	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to organic cyclic compound (GO:0014070)	3.07	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
single-organism metabolic process (GO:0044710)	1.63	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
protein complex subunit organization (GO:0071822)	2.6	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial respiratory chain complex I assembly (GO:0032981)	5.6	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase complex assembly (GO:0010257)	5.6	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular component organization (GO:0016043)	1.24	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
macromolecular complex assembly (GO:0065003)	2.55	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
electron transport chain (GO:0022900)	5.09	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular component organization or biogenesis (GO:0071840)	1.22	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
respiratory electron transport chain (GO:0022904)	5.11	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial respiratory chain complex assembly (GO:0033108)	5.31	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular process (GO:0009987)	0.26	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
protein complex assembly (GO:0006461)	2.78	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to stress (GO:0006950)	1.8	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
single-organism cellular process (GO:0044763)	0.65	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
metabolic process (GO:0008152)	0.58	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to chemical (GO:0042221)	1.98	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular protein complex assembly (GO:0043623)	3.9	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to organic substance (GO:0010033)	2.2	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidation-reduction process (GO:0055114)	2.91	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
single-organism process (GO:0044699)	0.48	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to stimulus (GO:0050896)	1.22	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular metabolic process (GO:0044237)	0.69	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.84	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cellular component biogenesis (GO:0044085)	4.46	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.6	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
response to endogenous stimulus (GO:0009719)	2.79	3	MT-ND4, MT-ND6, MT-ND3
response to oxygen-containing compound (GO:1901700)	2.57	3	MT-ND4, MT-ND6, MT-ND1
response to oxidative stress (GO:0006979)	3.9	3	MT-ND6, MT-ND3, MT-ND1
response to alkaloid (GO:0043279)	4.83	2	MT-ND4, MT-ND6
response to nitrogen compound (GO:1901698)	3.12	2	MT-ND4, MT-ND6
response to abiotic stimulus (GO:0009628)	2.8	2	MT-ND4, MT-ND3
response to nicotine (GO:0035094)	5.78	2	MT-ND4, MT-ND6
response to organonitrogen compound (GO:0010243)	3.2	2	MT-ND4, MT-ND6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	-	5.84	0.0	MT-ND4, MT-ND3, MT-ND1
electron transport chain (GO:0022900)	-	5.09	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
small molecule metabolic process (GO:0044281)	NEW	2.38	0.007	MT-ND6, MT-ND4, MT-ND3, MT-ND1
respiratory electron transport chain (GO:0022904)	-	5.11	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
generation of precursor metabolites and energy (GO:0006091)	-	4.07	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidation-reduction process (GO:0055114)	-	2.91	0.014	MT-ND6, MT-ND4, MT-ND3, MT-ND1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
organelle membrane (GO:0031090)	1.97	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cell part (GO:0044464)	0.11	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
integral component of membrane (GO:0016021)	1.14	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
membrane (GO:0016020)	0.68	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
organelle inner membrane (GO:0019866)	3.56	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
cytoplasmic part (GO:0044444)	0.82	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrion (GO:0005739)	2.42	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial membrane (GO:0031966)	3.31	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
intracellular organelle part (GO:0044446)	0.81	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial inner membrane (GO:0005743)	3.65	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
intracellular organelle (GO:0043229)	0.51	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
organelle part (GO:0044422)	0.79	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial part (GO:0044429)	2.92	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
intracellular part (GO:0044424)	0.28	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
membrane part (GO:0044425)	0.95	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
respiratory chain (GO:0070469)	5.51	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
membrane-bounded organelle (GO:0043227)	0.47	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
organelle (GO:0043226)	0.4	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
intrinsic component of membrane (GO:0031224)	1.13	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
intracellular membrane-bounded organelle (GO:0043231)	0.6	4	MT-ND6, MT-ND4, MT-ND3, MT-ND1
protein complex (GO:0043234)	1.51	3	MT-ND4, MT-ND3, MT-ND1
respiratory chain complex I (GO:0045271)	5.91	3	MT-ND4, MT-ND3, MT-ND1
macromolecular complex (GO:0032991)	1.35	3	MT-ND4, MT-ND3, MT-ND1
catalytic complex (GO:1902494)	2.9	3	MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase complex (GO:0030964)	5.91	3	MT-ND4, MT-ND3, MT-ND1
respiratory chain complex (GO:0098803)	5.47	3	MT-ND4, MT-ND3, MT-ND1
inner mitochondrial membrane protein complex (GO:0098800)	5.01	3	MT-ND4, MT-ND3, MT-ND1
mitochondrial membrane part (GO:0044455)	4.54	3	MT-ND4, MT-ND3, MT-ND1
membrane protein complex (GO:0098796)	2.84	3	MT-ND4, MT-ND3, MT-ND1
mitochondrial respiratory chain complex I (GO:0005747)	5.91	3	MT-ND4, MT-ND3, MT-ND1
oxidoreductase complex (GO:1990204)	5.19	3	MT-ND4, MT-ND3, MT-ND1
mitochondrial protein complex (GO:0098798)	4.78	3	MT-ND4, MT-ND3, MT-ND1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
respiratory chain complex I (GO:0045271)	-	5.91	0.0	MT-ND4, MT-ND3, MT-ND1
catalytic complex (GO:1902494)	-	2.9	0.006	MT-ND4, MT-ND3, MT-ND1
NADH dehydrogenase complex (GO:0030964)	-	5.91	0.0	MT-ND4, MT-ND3, MT-ND1
organelle inner membrane (GO:0019866)	-	3.56	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
organelle membrane (GO:0031090)	-	1.97	0.008	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial membrane (GO:0031966)	-	3.31	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial membrane part (GO:0044455)	-	4.54	0.0	MT-ND4, MT-ND3, MT-ND1
mitochondrial inner membrane (GO:0005743)	-	3.65	0.0	MT-ND6, MT-ND4, MT-ND3, MT-ND1
mitochondrial part (GO:0044429)	-	2.92	0.002	MT-ND6, MT-ND4, MT-ND3, MT-ND1
oxidoreductase complex (GO:1990204)	-	5.19	0.0	MT-ND4, MT-ND3, MT-ND1
mitochondrial respiratory chain complex I (GO:0005747)	-	5.91	0.0	MT-ND4, MT-ND3, MT-ND1