Disease table of MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES OMIM ID: 540000

Gene-disease associations table

Gene	Associated with MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MT-ND1	OMIM, HUMSAVAR	HGNC link	MT	6	500008, 535000, 540000, 500001, 502500, 252010
MT-TS1	OMIM	HGNC link	MT	3	500008, 540000, 545000
MT-CO3	HUMSAVAR	HGNC link	MT	4	540000, 550500, 535000, 256000
MT-ND4	HUMSAVAR	HGNC link	MT	3	540000, 500001, 535000
MT-ND5	OMIM, HUMSAVAR	HGNC link	MT	6	535000, 256000, 520100, 540000, 545000, 252010
MT-ND6	OMIM, HUMSAVAR	HGNC link	MT	5	535000, 553000, 540000, 252010, 500001
MT-TL1	OMIM	HGNC link	MT	4	545000, 500007, 540000, 520000
MT-TQ	OMIM	HGNC link	MT	1	540000
NDUFS1	ClinVar	HGNC link	2q33.3	2	540000, 252010
MT-TH	OMIM	HGNC link	MT	3	500008, 540000, 545000
MT-TK	OMIM	HGNC link	MT	3	545000, 540000, 520000
MT-TD	OMIM	HGNC link	MT	1	540000
MT-TS2	OMIM	HGNC link	MT	3	545000, 540000, 500004

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-CO3	No	-	1	NDUFA4
MT-ND1	MT-ND4	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND5	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	NDUFS1	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-CO3	MT-ND4	No	-	1	NDUFA4
MT-CO3	MT-ND5	No	-	1	NDUFA4
MT-CO3	MT-ND6	No	-	1	NDUFA4
MT-CO3	NDUFS1	No	-	2	NDUFA4, UQCRC2
MT-ND4	MT-ND5	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	NDUFS1	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFB2, MT-ND5, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND5	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND5	NDUFS1	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND6	NDUFS1	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND4	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND1	MT-ND5	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND6	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	NDUFS1	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-ND5	Yes	Respiratory chain complex I (beta subunit) mitochondrial	14	NDUFAB1, NDUFB10, NDUFB6, NDUFB2, NDUFA4, NDUFB4, NDUFB11, NDUFB1, NDUFB9, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND4	MT-ND6	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND4	NDUFS1	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND5	MT-ND6	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND5	NDUFS1	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND6	NDUFS1	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND5	Yes	10	NDUFS2, NDUFS1, NDUFV2, NDUFS8, SLC25A3, NDUFA5, NDUFS7, MPV17, NDUFV1, NDUFS3
MT-ND1	NDUFS1	Yes	7	NDUFS2, NDUFV2, MT-ND5, NDUFS8, NDUFS7, RHOT2, NDUFV1
MT-ND5	NDUFS1	Yes	6	NDUFS2, NDUFV2, NDUFS8, NDUFS7, MT-ND1, NDUFV1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Parkinson's disease	hsa05012	5.59	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Oxidative phosphorylation	hsa00190	5.69	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Huntington's disease	hsa05016	5.17	2	MT-CO3, NDUFS1
Alzheimer's disease	hsa05010	5.34	2	MT-CO3, NDUFS1
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	2	MT-CO3, NDUFS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.026	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Neurodegenerative diseases	NEW	4.27	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Global and overview maps	NEW	2.47	0.008	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Metabolism	NEW	2.06	0.036	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Oxidative phosphorylation (hsa00190)	-	5.69	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Metabolic pathways (hsa01100)	-	2.49	0.008	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Energy metabolism	NEW	5.42	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Huntington's disease (hsa05016)	-	5.17	0.015	MT-ND4, MT-CO3, NDUFS1
Alzheimer's disease (hsa05010)	-	5.34	0.0	MT-ND4, MT-ND1, MT-CO3, NDUFS1
Parkinson's disease (hsa05012)	-	5.59	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Respiratory electron transport	R-HSA-611105	6.44	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Metabolism (R-HSA-1430728)	-	2.34	0.001	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517)	-	5.71	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Respiratory electron transport (R-HSA-611105)	-	6.44	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200)	-	6.12	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
catalytic activity (GO:0003824)	1.05	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
oxidoreductase activity (GO:0016491)	3.12	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	5.93	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	5.13	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	5.66	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
NADH dehydrogenase activity (GO:0003954)	5.93	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
NADH dehydrogenase (quinone) activity (GO:0050136)	5.93	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
binding (GO:0005488)	0.18	3	NDUFS1, MT-CO3, MT-ND1
protein binding (GO:0005515)	0.46	3	NDUFS1, MT-CO3, MT-ND1
electron carrier activity (GO:0009055)	4.97	2	MT-CO3, NDUFS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	-	5.13	0.0	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	-	5.66	0.0	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
NADH dehydrogenase (quinone) activity (GO:0050136)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
oxidoreductase activity (GO:0016491)	-	3.12	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
NADH dehydrogenase activity (GO:0003954)	-	5.93	0.0	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
electron carrier activity (GO:0009055)	-	4.97	0.016	MT-CO3, NDUFS1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
protein complex assembly (GO:0006461)	2.78	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
single-organism metabolic process (GO:0044710)	1.63	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular component assembly (GO:0022607)	2.14	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
protein complex subunit organization (GO:0071822)	2.6	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
macromolecular complex subunit organization (GO:0043933)	2.14	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
single-organism process (GO:0044699)	0.48	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular process (GO:0009987)	0.26	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular component organization (GO:0016043)	1.24	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
macromolecular complex assembly (GO:0065003)	2.55	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
electron transport chain (GO:0022900)	5.09	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular macromolecular complex assembly (GO:0034622)	3.18	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular component organization or biogenesis (GO:0071840)	1.22	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
metabolic process (GO:0008152)	0.58	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
respiratory electron transport chain (GO:0022904)	5.11	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
single-organism cellular process (GO:0044763)	0.65	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular metabolic process (GO:0044237)	0.69	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular protein complex assembly (GO:0043623)	3.9	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
generation of precursor metabolites and energy (GO:0006091)	4.07	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
oxidation-reduction process (GO:0055114)	2.91	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial respiratory chain complex assembly (GO:0033108)	5.31	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial respiratory chain complex I assembly (GO:0032981)	5.6	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.6	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
protein complex biogenesis (GO:0070271)	5.37	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
NADH dehydrogenase complex assembly (GO:0010257)	5.6	5	MT-ND6, NDUFS1, MT-ND4, MT-ND5, MT-ND1
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.84	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
cellular component biogenesis (GO:0044085)	4.46	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
response to oxygen-containing compound (GO:1901700)	2.57	4	MT-ND6, MT-ND4, MT-ND5, MT-ND1
response to stimulus (GO:0050896)	1.22	4	MT-ND6, MT-ND4, MT-ND5, MT-ND1
response to stress (GO:0006950)	1.8	4	MT-ND6, MT-ND4, MT-ND5, MT-ND1
response to organic substance (GO:0010033)	2.2	4	MT-ND6, MT-ND4, MT-ND5, MT-ND1
response to chemical (GO:0042221)	1.98	4	MT-ND6, MT-ND4, MT-ND5, MT-ND1
response to endogenous stimulus (GO:0009719)	2.79	3	MT-ND4, MT-ND6, MT-ND5
response to nitrogen compound (GO:1901698)	3.12	3	MT-ND4, MT-ND6, MT-ND5
response to oxidative stress (GO:0006979)	3.9	3	MT-ND6, MT-ND5, MT-ND1
ATP synthesis coupled electron transport (GO:0042773)	7.65	3	MT-ND4, MT-ND5, NDUFS1
response to organonitrogen compound (GO:0010243)	3.2	3	MT-ND4, MT-ND6, MT-ND5
response to organic cyclic compound (GO:0014070)	3.07	3	MT-ND4, MT-ND6, MT-ND1
response to abiotic stimulus (GO:0009628)	2.8	2	MT-ND4, MT-ND5
response to inorganic substance (GO:0010035)	3.56	2	MT-ND6, MT-ND5
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	2	MT-CO3, NDUFS1
response to hydrogen peroxide (GO:0042542)	5.02	2	MT-ND6, MT-ND5
response to decreased oxygen levels (GO:0036293)	4.09	2	MT-ND4, MT-ND5
response to nicotine (GO:0035094)	5.78	2	MT-ND4, MT-ND6
response to reactive oxygen species (GO:0000302)	4.5	2	MT-ND6, MT-ND5
cellular respiration (GO:0045333)	5.9	2	MT-CO3, NDUFS1
response to alkaloid (GO:0043279)	4.83	2	MT-ND4, MT-ND6
response to hypoxia (GO:0001666)	4.13	2	MT-ND4, MT-ND5
response to oxygen levels (GO:0070482)	4.02	2	MT-ND4, MT-ND5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
single-organism metabolic process (GO:0044710)	-	1.63	0.029	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	-	5.84	0.0	MT-ND4, MT-ND1, MT-ND5, NDUFS1
electron transport chain (GO:0022900)	-	5.09	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cellular respiration (GO:0045333)	-	5.9	0.005	MT-CO3, NDUFS1
small molecule metabolic process (GO:0044281)	NEW	2.38	0.001	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
respiratory electron transport chain (GO:0022904)	-	5.11	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
generation of precursor metabolites and energy (GO:0006091)	-	4.07	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
oxidation-reduction process (GO:0055114)	-	2.91	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
organelle membrane (GO:0031090)	1.97	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
organelle inner membrane (GO:0019866)	3.56	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
membrane (GO:0016020)	0.68	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cell part (GO:0044464)	0.11	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
cytoplasmic part (GO:0044444)	0.82	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrion (GO:0005739)	2.42	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial membrane (GO:0031966)	3.31	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
intracellular organelle part (GO:0044446)	0.81	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial inner membrane (GO:0005743)	3.65	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
intracellular organelle (GO:0043229)	0.51	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial part (GO:0044429)	2.92	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
intracellular part (GO:0044424)	0.28	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
membrane part (GO:0044425)	0.95	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
membrane-bounded organelle (GO:0043227)	0.47	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
organelle (GO:0043226)	0.4	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
organelle part (GO:0044422)	0.79	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
protein complex (GO:0043234)	1.51	5	NDUFS1, MT-ND4, MT-ND5, MT-CO3, MT-ND1
macromolecular complex (GO:0032991)	1.35	5	NDUFS1, MT-ND4, MT-ND5, MT-CO3, MT-ND1
integral component of membrane (GO:0016021)	1.14	5	MT-ND6, MT-ND4, MT-ND5, MT-CO3, MT-ND1
respiratory chain complex (GO:0098803)	5.47	5	MT-ND4, MT-ND5, MT-ND1, MT-CO3, NDUFS1
membrane protein complex (GO:0098796)	2.84	5	MT-ND4, MT-ND5, MT-ND1, MT-CO3, NDUFS1
respiratory chain (GO:0070469)	5.51	5	MT-ND6, MT-ND4, MT-ND1, MT-ND5, NDUFS1
intrinsic component of membrane (GO:0031224)	1.13	5	MT-ND6, MT-ND4, MT-ND5, MT-CO3, MT-ND1
respiratory chain complex I (GO:0045271)	5.91	4	NDUFS1, MT-ND4, MT-ND5, MT-ND1
catalytic complex (GO:1902494)	2.9	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
NADH dehydrogenase complex (GO:0030964)	5.91	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
inner mitochondrial membrane protein complex (GO:0098800)	5.01	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial membrane part (GO:0044455)	4.54	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial respiratory chain complex I (GO:0005747)	5.91	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
oxidoreductase complex (GO:1990204)	5.19	4	MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial protein complex (GO:0098798)	4.78	4	NDUFS1, MT-ND4, MT-ND5, MT-ND1
neuron part (GO:0097458)	2.64	2	MT-ND5, MT-ND1
cell projection (GO:0042995)	2.47	2	MT-ND5, MT-ND1
neuron projection (GO:0043005)	3.12	2	MT-ND5, MT-ND1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
respiratory chain complex I (GO:0045271)	-	5.91	0.0	NDUFS1, MT-ND4, MT-ND5, MT-ND1
catalytic complex (GO:1902494)	-	2.9	0.001	MT-ND4, MT-ND1, MT-ND5, NDUFS1
NADH dehydrogenase complex (GO:0030964)	-	5.91	0.0	NDUFS1, MT-ND4, MT-ND5, MT-ND1
organelle inner membrane (GO:0019866)	-	3.56	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
organelle membrane (GO:0031090)	-	1.97	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
oxidoreductase complex (GO:1990204)	-	5.19	0.0	MT-ND4, MT-ND1, MT-ND5, NDUFS1
mitochondrial membrane part (GO:0044455)	-	4.54	0.0	MT-ND4, MT-ND5, MT-ND1, MT-CO3, NDUFS1
mitochondrial inner membrane (GO:0005743)	-	3.65	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial part (GO:0044429)	-	2.92	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
respiratory chain (GO:0070469)	-	5.51	0.002	MT-ND6, NDUFS1
mitochondrial membrane (GO:0031966)	-	3.31	0.0	MT-ND5, NDUFS1, MT-ND4, MT-CO3, MT-ND1, MT-ND6
mitochondrial respiratory chain complex I (GO:0005747)	-	5.91	0.0	NDUFS1, MT-ND4, MT-ND5, MT-ND1