Disease table of LEBER OPTIC ATROPHY OMIM ID: 535000

Gene-disease associations table

Gene	Associated with LEBER OPTIC ATROPHY in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MT-ND1	HUMSAVAR	HGNC link	MT	6	500008, 535000, 540000, 500001, 502500, 252010
MT-ND2	HUMSAVAR	HGNC link	MT	2	535000, 502500
MT-CO3	HUMSAVAR	HGNC link	MT	4	540000, 550500, 535000, 256000
MT-ND4	HUMSAVAR	HGNC link	MT	3	540000, 500001, 535000
MT-ND5	HUMSAVAR	HGNC link	MT	6	535000, 256000, 520100, 540000, 545000, 252010
MT-ND6	HUMSAVAR	HGNC link	MT	5	535000, 553000, 540000, 252010, 500001
MT-CYB	HUMSAVAR	HGNC link	MT	4	550500, 500000, 520100, 535000
MT-ND4L	HUMSAVAR	HGNC link	MT	2	520100, 535000
MT-ATP6	HUMSAVAR	HGNC link	MT	5	535000, 256000, 551500, 500003, 500011

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND2	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	MT-CO3	No	-	1	NDUFA4
MT-ND1	MT-ND4	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND5	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND1	MT-CYB	No	-	1	NDUFA4
MT-ND1	MT-ND4L	Yes	binding	43	NDUFS8, NDUFV2, NDUFB11, MT-ND2, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND2	MT-CO3	No	-	1	NDUFA4
MT-ND2	MT-ND4	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFB2, MT-ND5, NDUFS4, NDUFA4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND2	MT-ND5	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND2	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFA8, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND2	MT-CYB	No	-	1	NDUFA4
MT-ND2	MT-ND4L	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFB2, MT-ND5, NDUFS4, MT-ND4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-CO3	MT-ND4	No	-	1	NDUFA4
MT-CO3	MT-ND5	No	-	1	NDUFA4
MT-CO3	MT-ND6	No	-	1	NDUFA4
MT-CO3	MT-CYB	Yes	activation, binding	22	MT-CO1, CYCS, UQCRQ, CYC1, COX6A1, BCS1L, COX6C, COX5A, COX4I2, UQCRC1, UQCRB, COX6A2, COX7C, MT-CO2, UQCRC2, UQCRH, COX5B, UQCR10, NDUFA4, COX4I1, COX6B1, UQCRFS1
MT-CO3	MT-ND4L	No	-	1	NDUFA4
MT-CO3	MT-ATP6	Yes	binding	2	MT-CO1, OXA1L
MT-ND4	MT-ND5	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-CYB	No	-	1	NDUFA4
MT-ND4	MT-ND4L	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFB2, MT-ND5, NDUFS4, NDUFA4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND5	MT-ND6	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND5	MT-CYB	No	-	1	NDUFA4
MT-ND5	MT-ND4L	Yes	binding	43	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-ND6	MT-CYB	No	-	1	NDUFA4
MT-ND6	MT-ND4L	Yes	binding	40	NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA5, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA9, NDUFA12, MT-ND3, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFS6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2
MT-CYB	MT-ND4L	No	-	1	NDUFA4
MT-CYB	MT-ATP6	No	-	2	MT-CO1, MT-CO3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND2	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (incomplete intermediate ND1, ND2, ND3, CIA30 assembly), mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	43	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFAF1, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND4	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND1	MT-ND5	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND6	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND1	MT-ND4L	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, NDUFB11, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND2	MT-ND4	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND2	MT-ND5	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, NDUFA8, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND2	MT-ND6	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFA8, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND2	MT-ND4L	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, NDUFA8, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND4	MT-ND5	Yes	Respiratory chain complex I (beta subunit) mitochondrial	14	NDUFAB1, NDUFB10, NDUFB6, NDUFB2, NDUFA4, NDUFB4, NDUFB11, NDUFB1, NDUFB9, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND4	MT-ND6	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND4	MT-ND4L	No	-	15	NDUFAB1, NDUFB10, NDUFB6, MT-ND5, NDUFA4, NDUFB4, NDUFB2, NDUFB1, NDUFB9, NDUFB11, NDUFB7, NDUFB3, NDUFB8, NDUFB5, NDUFC2
MT-ND5	MT-ND6	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, MT-ND4L, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND5	MT-ND4L	Yes	Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2
MT-ND6	MT-ND4L	Yes	Respiratory chain complex I (gamma subunit) mitochondrial;Respiratory chain complex I (holoenzyme), mitochondrial	42	NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, NDUFC1, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, MT-ND5, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MT-ND1	MT-ND5	Yes	10	NDUFS2, NDUFS1, NDUFV2, NDUFS8, SLC25A3, NDUFA5, NDUFS7, MPV17, NDUFV1, NDUFS3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
MT-CO3	MT-CYB	yes, maybe indirect	Subunits MT-CO 1-3 form the functional core of the enzyme complex; component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex. [Uniprot]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Parkinson's disease	hsa05012	5.59	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Oxidative phosphorylation	hsa00190	5.69	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Huntington's disease	hsa05016	5.17	3	MT-ATP6, MT-CO3, MT-CYB
Alzheimer's disease	hsa05010	5.34	3	MT-ATP6, MT-CO3, MT-CYB
Cardiac muscle contraction	hsa04260	6.34	2	MT-CO3, MT-CYB
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	2	MT-CO3, MT-CYB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.001	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Neurodegenerative diseases	NEW	4.27	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Global and overview maps	NEW	2.47	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Metabolism	NEW	2.06	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Oxidative phosphorylation (hsa00190)	-	5.69	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Metabolic pathways (hsa01100)	-	2.49	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Energy metabolism	NEW	5.42	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.049	MT-ND2, MT-CO3, MT-CYB
Huntington's disease (hsa05016)	-	5.17	0.0	MT-ND4, MT-ND2, MT-CO3, MT-CYB, MT-ATP6
Alzheimer's disease (hsa05010)	-	5.34	0.0	MT-CO3, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND2
Parkinson's disease (hsa05012)	-	5.59	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Metabolism	R-HSA-1430728	2.34	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Respiratory electron transport	R-HSA-611105	6.44	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517)	-	5.71	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Respiratory electron transport (R-HSA-611105)	-	6.44	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200)	-	6.12	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
Metabolism (R-HSA-1430728)	-	2.34	0.001	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
catalytic activity (GO:0003824)	1.05	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
oxidoreductase activity (GO:0016491)	3.12	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	5.93	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	5.13	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	5.66	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
NADH dehydrogenase activity (GO:0003954)	5.93	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
NADH dehydrogenase (quinone) activity (GO:0050136)	5.93	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
binding (GO:0005488)	0.18	4	MT-ND2, MT-CO3, MT-ND1, MT-CYB
protein binding (GO:0005515)	0.46	4	MT-ND2, MT-CO3, MT-ND1, MT-CYB
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	3	MT-ATP6, MT-CO3, MT-CYB
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	3	MT-ATP6, MT-CO3, MT-CYB
substrate-specific transporter activity (GO:0022892)	2.72	3	MT-ATP6, MT-CO3, MT-CYB
transporter activity (GO:0005215)	2.57	3	MT-ATP6, MT-CO3, MT-CYB
cation transmembrane transporter activity (GO:0008324)	3.32	3	MT-ATP6, MT-CO3, MT-CYB
transmembrane transporter activity (GO:0022857)	2.82	3	MT-ATP6, MT-CO3, MT-CYB
ion transmembrane transporter activity (GO:0015075)	3.04	3	MT-ATP6, MT-CO3, MT-CYB
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	3	MT-ATP6, MT-CO3, MT-CYB
hydrogen ion transmembrane transporter activity (GO:0015078)	5.01	3	MT-ATP6, MT-CO3, MT-CYB
electron carrier activity (GO:0009055)	4.97	2	MT-CO3, MT-CYB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
catalytic activity (GO:0003824)	-	1.05	0.039	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
NADH dehydrogenase (ubiquinone) activity (GO:0008137)	-	5.93	0.0	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
hydrogen ion transmembrane transporter activity (GO:0015078)	-	5.01	0.001	MT-ATP6, MT-CO3, MT-CYB
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)	-	5.66	0.0	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.019	MT-ATP6, MT-CO3, MT-CYB
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	-	5.13	0.0	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
NADH dehydrogenase (quinone) activity (GO:0050136)	-	5.93	0.0	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
electron carrier activity (GO:0009055)	-	4.97	0.038	MT-CO3, MT-CYB
NADH dehydrogenase activity (GO:0003954)	-	5.93	0.0	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
oxidoreductase activity (GO:0016491)	-	3.12	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism metabolic process (GO:0044710)	1.63	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
cellular process (GO:0009987)	0.26	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
cellular metabolic process (GO:0044237)	0.69	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
single-organism cellular process (GO:0044763)	0.65	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
metabolic process (GO:0008152)	0.58	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
single-organism process (GO:0044699)	0.48	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
generation of precursor metabolites and energy (GO:0006091)	4.07	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
electron transport chain (GO:0022900)	5.09	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
oxidation-reduction process (GO:0055114)	2.91	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
respiratory electron transport chain (GO:0022904)	5.11	8	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
cellular component assembly (GO:0022607)	2.14	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
protein complex subunit organization (GO:0071822)	2.6	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
macromolecular complex subunit organization (GO:0043933)	2.14	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
response to stimulus (GO:0050896)	1.22	6	MT-ND5, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND6
protein complex assembly (GO:0006461)	2.78	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
cellular component organization (GO:0016043)	1.24	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.84	6	MT-ND4L, MT-ND5, MT-ND4, MT-ND2, MT-ND1, MT-ND6
macromolecular complex assembly (GO:0065003)	2.55	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
response to stress (GO:0006950)	1.8	6	MT-ND5, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND6
cellular macromolecular complex assembly (GO:0034622)	3.18	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
cellular protein complex assembly (GO:0043623)	3.9	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
cellular component organization or biogenesis (GO:0071840)	1.22	6	MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2
response to oxygen-containing compound (GO:1901700)	2.57	5	MT-ND6, MT-ND4, MT-ND5, MT-ND1, MT-CYB
mitochondrial respiratory chain complex assembly (GO:0033108)	5.31	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
mitochondrial respiratory chain complex I assembly (GO:0032981)	5.6	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.6	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
protein complex biogenesis (GO:0070271)	5.37	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
NADH dehydrogenase complex assembly (GO:0010257)	5.6	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
cellular component biogenesis (GO:0044085)	4.46	5	MT-ND6, MT-ND2, MT-ND5, MT-ND4, MT-ND1
response to chemical (GO:0042221)	1.98	5	MT-ND6, MT-ND4, MT-ND5, MT-ND1, MT-CYB
response to organic substance (GO:0010033)	2.2	5	MT-ND6, MT-ND4, MT-ND5, MT-ND1, MT-CYB
response to endogenous stimulus (GO:0009719)	2.79	4	MT-ND6, MT-ND4, MT-ND5, MT-CYB
response to abiotic stimulus (GO:0009628)	2.8	4	MT-ATP6, MT-ND5, MT-ND4, MT-CYB
response to organonitrogen compound (GO:0010243)	3.2	4	MT-ND6, MT-ND4, MT-ND5, MT-CYB
response to nitrogen compound (GO:1901698)	3.12	4	MT-ND6, MT-ND4, MT-ND5, MT-CYB
response to organic cyclic compound (GO:0014070)	3.07	4	MT-ND6, MT-ND4, MT-ND1, MT-CYB
response to oxygen levels (GO:0070482)	4.02	4	MT-ATP6, MT-ND5, MT-ND4, MT-CYB
hydrogen ion transmembrane transport (GO:1902600)	4.97	3	MT-ATP6, MT-CO3, MT-CYB
localization (GO:0051179)	1.4	3	MT-ATP6, MT-CO3, MT-CYB
response to hypoxia (GO:0001666)	4.13	3	MT-ND4, MT-ND5, MT-CYB
response to inorganic substance (GO:0010035)	3.56	3	MT-ND6, MT-ND5, MT-CYB
proton transport (GO:0015992)	4.73	3	MT-ATP6, MT-CO3, MT-CYB
ATP synthesis coupled electron transport (GO:0042773)	7.65	3	MT-ND4L, MT-ND4, MT-ND5
inorganic cation transmembrane transport (GO:0098662)	3.55	3	MT-ATP6, MT-CO3, MT-CYB
inorganic ion transmembrane transport (GO:0098660)	3.38	3	MT-ATP6, MT-CO3, MT-CYB
monovalent inorganic cation transport (GO:0015672)	3.74	3	MT-ATP6, MT-CO3, MT-CYB
developmental process (GO:0032502)	1.36	3	MT-ATP6, MT-ND4, MT-CYB
hydrogen transport (GO:0006818)	4.72	3	MT-ATP6, MT-CO3, MT-CYB
cation transport (GO:0006812)	3.11	3	MT-ATP6, MT-CO3, MT-CYB
ion transport (GO:0006811)	2.66	3	MT-ATP6, MT-CO3, MT-CYB
transport (GO:0006810)	1.51	3	MT-ATP6, MT-CO3, MT-CYB
single-organism developmental process (GO:0044767)	1.49	3	MT-ATP6, MT-ND4, MT-CYB
ion transmembrane transport (GO:0034220)	3.08	3	MT-ATP6, MT-CO3, MT-CYB
single-organism transport (GO:0044765)	2.18	3	MT-ATP6, MT-CO3, MT-CYB
establishment of localization (GO:0051234)	1.48	3	MT-ATP6, MT-CO3, MT-CYB
transmembrane transport (GO:0055085)	2.72	3	MT-ATP6, MT-CO3, MT-CYB
single-organism localization (GO:1902578)	2.09	3	MT-ATP6, MT-CO3, MT-CYB
response to decreased oxygen levels (GO:0036293)	4.09	3	MT-ND4, MT-ND5, MT-CYB
response to oxidative stress (GO:0006979)	3.9	3	MT-ND6, MT-ND5, MT-ND1
cation transmembrane transport (GO:0098655)	3.43	3	MT-ATP6, MT-CO3, MT-CYB
aging (GO:0007568)	4.16	2	MT-ATP6, MT-ND4
response to hydrogen peroxide (GO:0042542)	5.02	2	MT-ND6, MT-ND5
response to increased oxygen levels (GO:0036296)	6.4	2	MT-ATP6, MT-CYB
anatomical structure development (GO:0048856)	1.58	2	MT-ND4, MT-CYB
response to drug (GO:0042493)	3.71	2	MT-ND1, MT-CYB
response to nicotine (GO:0035094)	5.78	2	MT-ND4, MT-ND6
response to reactive oxygen species (GO:0000302)	4.5	2	MT-ND6, MT-ND5
response to ethanol (GO:0045471)	4.83	2	MT-ND4, MT-CYB
response to alkaloid (GO:0043279)	4.83	2	MT-ND4, MT-ND6
response to hyperoxia (GO:0055093)	6.4	2	MT-ATP6, MT-CYB
response to alcohol (GO:0097305)	4.58	2	MT-ND4, MT-CYB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
single-organism metabolic process (GO:0044710)	-	1.63	0.001	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
hydrogen transport (GO:0006818)	-	4.72	0.006	MT-ATP6, MT-CO3, MT-CYB
proton transport (GO:0015992)	-	4.73	0.006	MT-ATP6, MT-CO3, MT-CYB
hydrogen ion transmembrane transport (GO:1902600)	-	4.97	0.017	MT-ATP6, MT-CO3, MT-CYB
mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	-	5.84	0.0	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
electron transport chain (GO:0022900)	-	5.09	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
small molecule metabolic process (GO:0044281)	NEW	2.38	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
respiratory electron transport chain (GO:0022904)	-	5.11	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
generation of precursor metabolites and energy (GO:0006091)	-	4.07	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
oxidation-reduction process (GO:0055114)	-	2.91	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
organelle membrane (GO:0031090)	1.97	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
integral component of membrane (GO:0016021)	1.14	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
membrane (GO:0016020)	0.68	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
cell part (GO:0044464)	0.11	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
cytoplasmic part (GO:0044444)	0.82	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrion (GO:0005739)	2.42	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial membrane (GO:0031966)	3.31	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intracellular organelle part (GO:0044446)	0.81	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intracellular organelle (GO:0043229)	0.51	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
organelle part (GO:0044422)	0.79	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial part (GO:0044429)	2.92	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intracellular part (GO:0044424)	0.28	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
membrane part (GO:0044425)	0.95	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
membrane-bounded organelle (GO:0043227)	0.47	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
organelle (GO:0043226)	0.4	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intrinsic component of membrane (GO:0031224)	1.13	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intracellular membrane-bounded organelle (GO:0043231)	0.6	9	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
protein complex (GO:0043234)	1.51	8	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
membrane protein complex (GO:0098796)	2.84	8	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
organelle inner membrane (GO:0019866)	3.56	8	MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
macromolecular complex (GO:0032991)	1.35	8	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
mitochondrial inner membrane (GO:0005743)	3.65	8	MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial membrane part (GO:0044455)	4.54	7	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND2
respiratory chain (GO:0070469)	5.51	7	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ND2, MT-ND1, MT-ND6
mitochondrial protein complex (GO:0098798)	4.78	7	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND2
respiratory chain complex (GO:0098803)	5.47	7	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ND1, MT-ND2
inner mitochondrial membrane protein complex (GO:0098800)	5.01	7	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ATP6, MT-ND1, MT-ND2
catalytic complex (GO:1902494)	2.9	6	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ND1, MT-ND2
oxidoreductase complex (GO:1990204)	5.19	6	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ND1, MT-ND2
NADH dehydrogenase complex (GO:0030964)	5.91	5	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
respiratory chain complex I (GO:0045271)	5.91	5	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
mitochondrial respiratory chain complex I (GO:0005747)	5.91	5	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
neuron part (GO:0097458)	2.64	3	MT-ND2, MT-ND5, MT-ND1
cell projection (GO:0042995)	2.47	2	MT-ND5, MT-ND1
neuron projection (GO:0043005)	3.12	2	MT-ND5, MT-ND1
cytochrome complex (GO:0070069)	6.51	2	MT-CO3, MT-CYB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.001	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
mitochondrial membrane part (GO:0044455)	-	4.54	0.0	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
respiratory chain complex I (GO:0045271)	-	5.91	0.0	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
macromolecular complex (GO:0032991)	-	1.35	0.005	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-CO3, MT-ATP6, MT-ND1, MT-ND2
organelle membrane (GO:0031090)	-	1.97	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
NADH dehydrogenase complex (GO:0030964)	-	5.91	0.0	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1
membrane (GO:0016020)	-	0.68	0.007	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
organelle inner membrane (GO:0019866)	-	3.56	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
catalytic complex (GO:1902494)	-	2.9	0.004	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ND1, MT-ND2
cytochrome complex (GO:0070069)	-	6.51	0.002	MT-CO3, MT-CYB
mitochondrial membrane (GO:0031966)	-	3.31	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
intracellular organelle part (GO:0044446)	-	0.81	0.005	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial inner membrane (GO:0005743)	-	3.65	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
cytoplasmic part (GO:0044444)	-	0.82	0.01	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial part (GO:0044429)	-	2.92	0.0	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
membrane part (GO:0044425)	-	0.95	0.004	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
oxidoreductase complex (GO:1990204)	-	5.19	0.0	MT-ND4L, MT-ND5, MT-CYB, MT-ND4, MT-ND1, MT-ND2
integral component of membrane (GO:0016021)	-	1.14	0.013	MT-ND4L, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
organelle part (GO:0044422)	-	0.79	0.006	MT-ND4L, MT-CYB, MT-CO3, MT-ND5, MT-ND4, MT-ND6, MT-ND1, MT-ND2, MT-ATP6
mitochondrial respiratory chain complex I (GO:0005747)	-	5.91	0.0	MT-ND4L, MT-ND2, MT-ND5, MT-ND4, MT-ND1