Disease table of DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL OMIM ID: 500008

Gene-disease associations table

GeneAssociated with DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MT-CO1OMIMHGNC linkMT4550500, 500008, 220110, 114500
MT-ND1OMIMHGNC linkMT6500008, 535000, 540000, 500001, 502500, 252010
MT-RNR1OMIMHGNC linkMT1500008
MT-TIOMIMHGNC linkMT2500008, 500005
MT-THOMIMHGNC linkMT3500008, 540000, 545000
MT-TS1OMIMHGNC linkMT3500008, 540000, 545000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MT-CO1MT-ND1No-2NDUFA4, NDUFB8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.492MT-CO1, MT-ND1
Parkinson's diseasehsa050125.592MT-CO1, MT-ND1
Oxidative phosphorylationhsa001905.692MT-CO1, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.043MT-CO1, MT-ND1
Oxidative phosphorylation (hsa00190) -5.690.006MT-CO1, MT-ND1
Energy metabolismNEW5.420.01MT-CO1, MT-ND1
Alzheimer's disease (hsa05010) NEW5.340.019MT-CO1, MT-ND1
Parkinson's disease (hsa05012) -5.590.012MT-CO1, MT-ND1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.342MT-CO1, MT-ND1
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.712MT-CO1, MT-ND1
Respiratory electron transportR-HSA-6111056.442MT-CO1, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.122MT-CO1, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.006MT-CO1, MT-ND1
Respiratory electron transport (R-HSA-611105) -6.440.001MT-CO1, MT-ND1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.003MT-CO1, MT-ND1
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.052MT-CO1, MT-ND1
binding (GO:0005488) 0.182MT-CO1, MT-ND1
protein binding (GO:0005515) 0.462MT-CO1, MT-ND1
oxidoreductase activity (GO:0016491) 3.122MT-CO1, MT-ND1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism metabolic process (GO:0044710) 1.632MT-CO1, MT-ND1
response to stimulus (GO:0050896) 1.222MT-CO1, MT-ND1
cellular process (GO:0009987) 0.262MT-CO1, MT-ND1
cellular metabolic process (GO:0044237) 0.692MT-CO1, MT-ND1
response to stress (GO:0006950) 1.82MT-CO1, MT-ND1
electron transport chain (GO:0022900) 5.092MT-CO1, MT-ND1
single-organism cellular process (GO:0044763) 0.652MT-CO1, MT-ND1
single-organism process (GO:0044699) 0.482MT-CO1, MT-ND1
metabolic process (GO:0008152) 0.582MT-CO1, MT-ND1
respiratory electron transport chain (GO:0022904) 5.112MT-CO1, MT-ND1
response to chemical (GO:0042221) 1.982MT-CO1, MT-ND1
generation of precursor metabolites and energy (GO:0006091) 4.072MT-CO1, MT-ND1
response to oxidative stress (GO:0006979) 3.92MT-CO1, MT-ND1
oxidation-reduction process (GO:0055114) 2.912MT-CO1, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
generation of precursor metabolites and energy (GO:0006091) -4.070.029MT-CO1, MT-ND1
electron transport chain (GO:0022900) -5.090.01MT-CO1, MT-ND1
respiratory electron transport chain (GO:0022904) -5.110.003MT-CO1, MT-ND1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.112MT-CO1, MT-ND1
intracellular organelle (GO:0043229) 0.512MT-CO1, MT-ND1
membrane-bounded organelle (GO:0043227) 0.472MT-CO1, MT-ND1
organelle (GO:0043226) 0.42MT-CO1, MT-ND1
intrinsic component of membrane (GO:0031224) 1.132MT-CO1, MT-ND1
organelle membrane (GO:0031090) 1.972MT-CO1, MT-ND1
mitochondrial inner membrane (GO:0005743) 3.652MT-CO1, MT-ND1
integral component of membrane (GO:0016021) 1.142MT-CO1, MT-ND1
membrane (GO:0016020) 0.682MT-CO1, MT-ND1
respiratory chain complex (GO:0098803) 5.472MT-CO1, MT-ND1
mitochondrion (GO:0005739) 2.422MT-CO1, MT-ND1
inner mitochondrial membrane protein complex (GO:0098800) 5.012MT-CO1, MT-ND1
mitochondrial membrane part (GO:0044455) 4.542MT-CO1, MT-ND1
mitochondrial membrane (GO:0031966) 3.312MT-CO1, MT-ND1
protein complex (GO:0043234) 1.512MT-CO1, MT-ND1
macromolecular complex (GO:0032991) 1.352MT-CO1, MT-ND1
intracellular membrane-bounded organelle (GO:0043231) 0.62MT-CO1, MT-ND1
organelle inner membrane (GO:0019866) 3.562MT-CO1, MT-ND1
intracellular organelle part (GO:0044446) 0.812MT-CO1, MT-ND1
membrane protein complex (GO:0098796) 2.842MT-CO1, MT-ND1
cytoplasmic part (GO:0044444) 0.822MT-CO1, MT-ND1
mitochondrial part (GO:0044429) 2.922MT-CO1, MT-ND1
intracellular part (GO:0044424) 0.282MT-CO1, MT-ND1
membrane part (GO:0044425) 0.952MT-CO1, MT-ND1
respiratory chain (GO:0070469) 5.512MT-CO1, MT-ND1
organelle part (GO:0044422) 0.792MT-CO1, MT-ND1
mitochondrial protein complex (GO:0098798) 4.782MT-CO1, MT-ND1

NET-GE enrichment

Term New enriched termICP valueGenes
organelle inner membrane (GO:0019866) -3.560.043MT-CO1, MT-ND1
mitochondrial membrane (GO:0031966) -3.310.016MT-CO1, MT-ND1
mitochondrial membrane part (GO:0044455) -4.540.004MT-CO1, MT-ND1
mitochondrial inner membrane (GO:0005743) -3.650.034MT-CO1, MT-ND1
mitochondrial part (GO:0044429) -2.920.048MT-CO1, MT-ND1