Disease table of BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1 OMIM ID: 605462

Gene-disease associations table

GeneAssociated with BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1 inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PTCH2OMIMHGNC link1p34.13605462, 109400, 155255
SMOOMIMHGNC link7q32.11605462
PTCH1OMIM, HUMSAVARHGNC link9q22.324605462, 109400, PS142623, PS236100
RASA1OMIMHGNC link5q14.33605462, 608354, 608355

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SMOYES1GLI30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTCH2SMOYes0
PTCH2PTCH1No1SMO
SMOPTCH1Yes1NEDD4
PTCH1RASA1No1EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTCH2SMOYesbinding5IHH, SHH, GLI3, GLI2, GLI1
PTCH2PTCH1No-9DHH, BMP2, BMP4, SMO, GLI2, GLI1, IHH, GLI3, SHH
SMOPTCH1Yesactivation6GLI1, IHH, GLI2, GLI3, SHH, NEDD4
PTCH1RASA1No-2UBC, CDK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
PTCH1PTCH2maybe, indirectThey are homologos, part ofthe patched gene family. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Hedgehog signaling pathwayhsa043407.013PTCH2, PTCH1, SMO
Pathways in cancerhsa052003.983PTCH2, PTCH1, SMO
Basal cell carcinomahsa052176.793PTCH2, PTCH1, SMO
Proteoglycans in cancerhsa052055.022SMO, PTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
Proteoglycans in cancer (hsa05205) -5.020.014RASA1, SMO, PTCH1
Hedgehog signaling pathway (hsa04340) -7.010.0PTCH2, PTCH1, SMO
Pathways in cancer (hsa05200) -3.980.005RASA1, SMO, PTCH1, PTCH2
Cancers: Specific typesNEW4.10.012RASA1, PTCH2, PTCH1, SMO
Basal cell carcinoma (hsa05217) -6.790.0PTCH2, PTCH1, SMO
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.784RASA1, PTCH2, PTCH1, SMO
Signaling by GPCRR-HSA-3727902.684RASA1, SMO, PTCH1, PTCH2
Class B/2 (Secretin family receptors)R-HSA-3730806.523SMO, PTCH1, PTCH2
GPCR ligand bindingR-HSA-5007924.193PTCH2, PTCH1, SMO
Hedgehog 'on' stateR-HSA-56326846.622SMO, PTCH1
Hedgehog 'off' stateR-HSA-56107876.192SMO, PTCH1
Signaling by HedgehogR-HSA-53583515.792SMO, PTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
Class B/2 (Secretin family receptors) (R-HSA-373080) -6.520.0PTCH2, PTCH1, SMO
Hedgehog 'on' state (R-HSA-5632684) -6.620.047SMO, PTCH1
GPCR ligand binding (R-HSA-500792) -4.190.048PTCH2, PTCH1, SMO
Signaling by GPCR (R-HSA-372790) -2.680.046RASA1, SMO, PTCH1, PTCH2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
receptor binding (GO:0005102) 2.434RASA1, SMO, PTCH1, PTCH2
binding (GO:0005488) 0.184RASA1, SMO, PTCH1, PTCH2
protein binding (GO:0005515) 0.464RASA1, PTCH2, PTCH1, SMO
signaling receptor activity (GO:0038023) 2.493PTCH2, PTCH1, SMO
molecular transducer activity (GO:0060089) 2.323SMO, PTCH1, PTCH2
transmembrane signaling receptor activity (GO:0004888) 2.573PTCH2, PTCH1, SMO
receptor activity (GO:0004872) 2.323PTCH2, PTCH1, SMO
signal transducer activity (GO:0004871) 2.283PTCH2, PTCH1, SMO
transmembrane receptor activity (GO:0099600) 2.533SMO, PTCH1, PTCH2
carbohydrate derivative binding (GO:0097367) 2.032RASA1, PTCH1
hedgehog receptor activity (GO:0008158) 8.642PTCH2, PTCH1
hedgehog family protein binding (GO:0097108) 8.642PTCH2, PTCH1
patched binding (GO:0005113) 7.662SMO, PTCH1
smoothened binding (GO:0005119) 8.642PTCH2, PTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
patched binding (GO:0005113) -7.660.0SMO, PTCH1
receptor binding (GO:0005102) -2.430.001RASA1, SMO, PTCH1, PTCH2
hedgehog family protein binding (GO:0097108) -8.640.0PTCH2, PTCH1
hedgehog receptor activity (GO:0008158) -8.640.0PTCH2, PTCH1
smoothened binding (GO:0005119) -8.640.0PTCH2, PTCH1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.364RASA1, PTCH2, PTCH1, SMO
single-organism process (GO:0044699) 0.484RASA1, SMO, PTCH1, PTCH2
multicellular organismal process (GO:0032501) 1.454RASA1, SMO, PTCH1, PTCH2
single-multicellular organism process (GO:0044707) 1.784RASA1, PTCH2, PTCH1, SMO
regulation of developmental process (GO:0050793) 2.14RASA1, PTCH2, PTCH1, SMO
cellular developmental process (GO:0048869) 1.824RASA1, SMO, PTCH1, PTCH2
anatomical structure development (GO:0048856) 1.584RASA1, SMO, PTCH1, PTCH2
regulation of response to stimulus (GO:0048583) 1.544RASA1, SMO, PTCH1, PTCH2
regulation of cellular process (GO:0050794) 0.54RASA1, SMO, PTCH1, PTCH2
regulation of signal transduction (GO:0009966) 1.844RASA1, PTCH2, PTCH1, SMO
biological regulation (GO:0065007) 0.394RASA1, SMO, PTCH1, PTCH2
single-organism cellular process (GO:0044763) 0.654RASA1, PTCH2, PTCH1, SMO
signal transduction (GO:0007165) 1.284RASA1, PTCH2, PTCH1, SMO
regulation of signaling (GO:0023051) 1.724RASA1, PTCH2, PTCH1, SMO
negative regulation of biological process (GO:0048519) 1.334RASA1, PTCH2, PTCH1, SMO
cellular process (GO:0009987) 0.264RASA1, SMO, PTCH1, PTCH2
regulation of cell communication (GO:0010646) 1.734RASA1, PTCH2, PTCH1, SMO
regulation of biological process (GO:0050789) 0.454RASA1, PTCH2, PTCH1, SMO
negative regulation of cellular process (GO:0048523) 1.414RASA1, SMO, PTCH1, PTCH2
regulation of smoothened signaling pathway (GO:0008589) 5.623SMO, PTCH1, PTCH2
regulation of primary metabolic process (GO:0080090) 1.083RASA1, SMO, PTCH1
regulation of metabolic process (GO:0019222) 1.023RASA1, SMO, PTCH1
negative regulation of response to stimulus (GO:0048585) 2.523RASA1, PTCH2, PTCH1
cell differentiation (GO:0030154) 2.143RASA1, SMO, PTCH1
regulation of cellular metabolic process (GO:0031323) 1.073RASA1, SMO, PTCH1
negative regulation of signaling (GO:0023057) 2.653RASA1, PTCH2, PTCH1
positive regulation of developmental process (GO:0051094) 2.773PTCH2, PTCH1, SMO
negative regulation of cell communication (GO:0010648) 2.663RASA1, PTCH2, PTCH1
cell surface receptor signaling pathway (GO:0007166) 2.093RASA1, SMO, PTCH1
regulation of epidermis development (GO:0045682) 5.573SMO, PTCH1, PTCH2
anatomical structure morphogenesis (GO:0009653) 2.533RASA1, SMO, PTCH1
multicellular organism development (GO:0007275) 2.543RASA1, SMO, PTCH1
cellular component organization or biogenesis (GO:0071840) 1.223RASA1, SMO, PTCH1
negative regulation of signal transduction (GO:0009968) 2.753RASA1, PTCH2, PTCH1
cell fate specification (GO:0001708) 5.573PTCH2, PTCH1, SMO
cellular component organization (GO:0016043) 1.243RASA1, SMO, PTCH1
regulation of macromolecule metabolic process (GO:0060255) 1.083RASA1, SMO, PTCH1
animal organ development (GO:0048513) 2.533PTCH2, PTCH1, SMO
regulation of epithelial cell differentiation (GO:0030856) 4.963PTCH2, PTCH1, SMO
positive regulation of biological process (GO:0048518) 1.23SMO, PTCH1, PTCH2
regulation of molecular function (GO:0065009) 1.783RASA1, SMO, PTCH1
regulation of biological quality (GO:0065008) 1.683RASA1, SMO, PTCH1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433RASA1, SMO, PTCH1
tissue development (GO:0009888) 3.273PTCH2, PTCH1, SMO
single-organism developmental process (GO:0044767) 1.493RASA1, SMO, PTCH1
regulation of cell differentiation (GO:0045595) 2.423PTCH2, PTCH1, SMO
regulation of nitrogen compound metabolic process (GO:0051171) 1.363RASA1, SMO, PTCH1
regulation of multicellular organismal process (GO:0051239) 1.873SMO, PTCH1, PTCH2
positive regulation of cell differentiation (GO:0045597) 3.013SMO, PTCH1, PTCH2
embryo development (GO:0009790) 4.23RASA1, SMO, PTCH1
regulation of RNA metabolic process (GO:0051252) 1.523RASA1, SMO, PTCH1
regulation of multicellular organismal development (GO:2000026) 2.313PTCH2, PTCH1, SMO
positive regulation of cellular process (GO:0048522) 1.33SMO, PTCH1, PTCH2
protein localization (GO:0008104) 2.362SMO, PTCH1
regulation of transport (GO:0051049) 2.242SMO, PTCH1
cellular response to stimulus (GO:0051716) 1.972SMO, PTCH1
response to cholesterol (GO:0070723) 6.682SMO, PTCH1
negative regulation of macromolecule metabolic process (GO:0010605) 2.012SMO, PTCH1
positive regulation of macromolecule metabolic process (GO:0010604) 1.812SMO, PTCH1
cellular macromolecule localization (GO:0070727) 3.12SMO, PTCH1
cellular response to organic substance (GO:0071310) 2.782SMO, PTCH1
positive regulation of molecular function (GO:0044093) 2.232SMO, RASA1
epithelial cell differentiation (GO:0030855) 3.982SMO, PTCH1
positive regulation of epithelial cell differentiation (GO:0030858) 5.762PTCH2, PTCH1
macromolecule localization (GO:0033036) 2.342SMO, PTCH1
regulation of cell proliferation (GO:0042127) 2.412SMO, PTCH1
positive regulation of transport (GO:0051050) 2.92SMO, PTCH1
negative regulation of cell death (GO:0060548) 2.952SMO, RASA1
heart morphogenesis (GO:0003007) 5.842SMO, PTCH1
regionalization (GO:0003002) 4.242SMO, PTCH1
regulation of RNA biosynthetic process (GO:2001141) 1.552SMO, PTCH1
response to organic substance (GO:0010033) 2.22SMO, PTCH1
protein metabolic process (GO:0019538) 1.452RASA1, PTCH1
negative regulation of metabolic process (GO:0009892) 1.932SMO, PTCH1
positive regulation of metabolic process (GO:0009893) 1.742SMO, PTCH1
negative regulation of biosynthetic process (GO:0009890) 2.472SMO, PTCH1
positive regulation of biosynthetic process (GO:0009891) 2.292SMO, PTCH1
embryonic organ development (GO:0048568) 4.862SMO, PTCH1
negative regulation of gene expression (GO:0010629) 2.482SMO, PTCH1
positive regulation of gene expression (GO:0010628) 2.352SMO, PTCH1
regulation of apoptotic process (GO:0042981) 2.52SMO, RASA1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242SMO, PTCH1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792SMO, RASA1
organ morphogenesis (GO:0009887) 3.552SMO, PTCH1
regulation of biosynthetic process (GO:0009889) 1.372SMO, PTCH1
negative regulation of smoothened signaling pathway (GO:0045879) 6.552PTCH2, PTCH1
metabolic process (GO:0008152) 0.582RASA1, PTCH1
epidermal cell fate specification (GO:0009957) 8.632PTCH2, PTCH1
vasculogenesis (GO:0001570) 5.652SMO, RASA1
dorsal/ventral pattern formation (GO:0009953) 5.62SMO, PTCH1
smoothened signaling pathway (GO:0007224) 5.452SMO, PTCH1
response to stimulus (GO:0050896) 1.222SMO, PTCH1
regulation of transcription, DNA-templated (GO:0006355) 1.562SMO, PTCH1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392SMO, PTCH1
regulation of macromolecule biosynthetic process (GO:0010556) 1.432SMO, PTCH1
response to alcohol (GO:0097305) 4.582SMO, PTCH1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532SMO, PTCH1
cellular response to alcohol (GO:0097306) 6.072SMO, PTCH1
regulation of developmental growth (GO:0048638) 4.042SMO, PTCH1
cell fate determination (GO:0001709) 5.972PTCH2, PTCH1
embryo development ending in birth or egg hatching (GO:0009792) 4.352SMO, PTCH1
cellular response to chemical stimulus (GO:0070887) 2.572SMO, PTCH1
axis specification (GO:0009798) 5.422SMO, PTCH1
epidermis development (GO:0008544) 5.042PTCH2, PTCH1
response to organic cyclic compound (GO:0014070) 3.072SMO, PTCH1
regulation of protein localization (GO:0032880) 2.882SMO, PTCH1
in utero embryonic development (GO:0001701) 4.42SMO, PTCH1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122SMO, PTCH1
negative regulation of multicellular organismal process (GO:0051241) 2.842SMO, PTCH1
epithelial tube morphogenesis (GO:0060562) 5.122SMO, PTCH1
chordate embryonic development (GO:0043009) 4.382SMO, PTCH1
central nervous system neuron differentiation (GO:0021953) 5.172SMO, PTCH1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562SMO, PTCH1
tube morphogenesis (GO:0035239) 4.352SMO, PTCH1
cellular response to oxygen-containing compound (GO:1901701) 3.222SMO, PTCH1
negative regulation of molecular function (GO:0044092) 2.742SMO, PTCH1
cellular response to lipid (GO:0071396) 3.962SMO, PTCH1
cellular response to cholesterol (GO:0071397) 7.242SMO, PTCH1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552SMO, PTCH1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712SMO, PTCH1
negative regulation of cell differentiation (GO:0045596) 3.332SMO, PTCH1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752SMO, PTCH1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562SMO, PTCH1
renal system development (GO:0072001) 6.732SMO, PTCH1
regulation of localization (GO:0032879) 1.942SMO, PTCH1
somite development (GO:0061053) 7.022SMO, PTCH1
negative regulation of developmental process (GO:0051093) 3.172SMO, PTCH1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832SMO, PTCH1
regulation of epithelial cell proliferation (GO:0050678) 4.062SMO, PTCH1
cellular response to organic cyclic compound (GO:0071407) 3.932SMO, PTCH1
negative regulation of RNA metabolic process (GO:0051253) 2.662SMO, PTCH1
positive regulation of RNA metabolic process (GO:0051254) 2.512SMO, PTCH1
macromolecule metabolic process (GO:0043170) 0.832RASA1, PTCH1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542SMO, PTCH1
system development (GO:0048731) 2.922SMO, PTCH1
dorsal/ventral neural tube patterning (GO:0021904) 7.092SMO, PTCH1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32SMO, PTCH1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492SMO, PTCH1
regulation of cellular biosynthetic process (GO:0031326) 1.382SMO, PTCH1
positive regulation of cellular metabolic process (GO:0031325) 1.812SMO, PTCH1
negative regulation of cellular metabolic process (GO:0031324) 2.012SMO, PTCH1
homeostatic process (GO:0042592) 2.612SMO, PTCH1
regulation of cell death (GO:0010941) 2.432SMO, RASA1
positive regulation of epidermis development (GO:0045684) 6.262PTCH2, PTCH1
pattern specification process (GO:0007389) 3.792SMO, PTCH1
response to lipid (GO:0033993) 3.112SMO, PTCH1
regulation of growth (GO:0040008) 3.262SMO, PTCH1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462SMO, PTCH1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62SMO, PTCH1
organic substance metabolic process (GO:0071704) 0.632RASA1, PTCH1
regulation of programmed cell death (GO:0043067) 2.492SMO, RASA1
negative regulation of apoptotic process (GO:0043066) 3.042SMO, RASA1
positive regulation of epidermal cell differentiation (GO:0045606) 6.732PTCH2, PTCH1
tissue morphogenesis (GO:0048729) 3.872SMO, PTCH1
regulation of epidermal cell differentiation (GO:0045604) 5.922PTCH2, PTCH1
negative regulation of programmed cell death (GO:0043069) 3.022SMO, RASA1
regulation of gene expression (GO:0010468) 1.372SMO, PTCH1
embryonic morphogenesis (GO:0048598) 3.722SMO, PTCH1
epithelium development (GO:0060429) 4.572SMO, PTCH1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352SMO, PTCH1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552SMO, PTCH1
neuron differentiation (GO:0030182) 4.172SMO, PTCH1
morphogenesis of an epithelium (GO:0002009) 4.082SMO, PTCH1
cellular protein localization (GO:0034613) 3.112SMO, PTCH1
negative regulation of RNA biosynthetic process (GO:1902679) 2.72SMO, PTCH1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472SMO, PTCH1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292SMO, PTCH1
response to chemical (GO:0042221) 1.982SMO, PTCH1
cellular response to sterol (GO:0036315) 7.022SMO, PTCH1
response to sterol (GO:0036314) 6.552SMO, PTCH1
localization (GO:0051179) 1.42SMO, PTCH1
mammary gland epithelial cell differentiation (GO:0060644) 6.92SMO, PTCH1
cellular localization (GO:0051641) 2.322SMO, PTCH1
response to oxygen-containing compound (GO:1901700) 2.572SMO, PTCH1
primary metabolic process (GO:0044238) 0.692RASA1, PTCH1
regulation of multicellular organism growth (GO:0040014) 5.482SMO, PTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
vasculogenesis (GO:0001570) -5.650.035SMO, RASA1
regulation of smoothened signaling pathway (GO:0008589) -5.620.002PTCH2, PTCH1, SMO
response to cholesterol (GO:0070723) -6.680.003SMO, PTCH1
dorsal/ventral pattern formation (GO:0009953) -5.60.037SMO, PTCH1
smoothened signaling pathway (GO:0007224) -5.450.045SMO, PTCH1
single-organism cellular localization (GO:1902580) NEW3.160.023RASA1, SMO, PTCH1
epithelium development (GO:0060429) -4.570.005SMO, PTCH1, PTCH2
negative regulation of smoothened signaling pathway (GO:0045879) -6.550.006PTCH2, PTCH1, SMO
cellular response to cholesterol (GO:0071397) -7.240.001SMO, PTCH1
heart morphogenesis (GO:0003007) -5.840.012SMO, PTCH1
embryo development (GO:0009790) -4.20.007RASA1, SMO, PTCH1
embryonic digestive tract morphogenesis (GO:0048557) NEW6.90.03SMO, PTCH1
somite development (GO:0061053) -7.020.007SMO, PTCH1
protein localization to membrane (GO:0072657) NEW3.950.012RASA1, SMO, PTCH1
single-organism localization (GO:1902578) NEW2.090.023RASA1, SMO, PTCH1
cellular response to sterol (GO:0036315) -7.020.013SMO, PTCH1
response to sterol (GO:0036314) -6.550.036SMO, PTCH1
renal system development (GO:0072001) -6.730.001SMO, PTCH1
mammary gland epithelial cell differentiation (GO:0060644) -6.90.013SMO, PTCH1
cellular response to alcohol (GO:0097306) -6.070.04SMO, PTCH1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane part (GO:0044425) 0.954RASA1, SMO, PTCH1, PTCH2
membrane (GO:0016020) 0.684RASA1, PTCH2, PTCH1, SMO
intrinsic component of membrane (GO:0031224) 1.134RASA1, PTCH2, PTCH1, SMO
integral component of membrane (GO:0016021) 1.143SMO, PTCH1, PTCH2
cell part (GO:0044464) 0.113RASA1, SMO, PTCH1
cytoplasmic part (GO:0044444) 0.823RASA1, SMO, PTCH1
plasma membrane (GO:0005886) 1.393RASA1, SMO, PTCH1
intracellular part (GO:0044424) 0.283RASA1, SMO, PTCH1
cell projection (GO:0042995) 2.473RASA1, SMO, PTCH1
plasma membrane part (GO:0044459) 1.953RASA1, SMO, PTCH1
plasma membrane region (GO:0098590) 2.972SMO, PTCH1
cell projection part (GO:0044463) 2.972SMO, PTCH1
ciliary membrane (GO:0060170) 5.432SMO, PTCH1
caveola (GO:0005901) 5.552SMO, PTCH1
intracellular organelle (GO:0043229) 0.512SMO, PTCH1
cilium (GO:0005929) 3.892SMO, PTCH1
plasma membrane raft (GO:0044853) 5.422SMO, PTCH1
membrane-bounded organelle (GO:0043227) 0.472SMO, PTCH1
organelle (GO:0043226) 0.42SMO, PTCH1
cytoplasm (GO:0005737) 1.012SMO, RASA1
primary cilium (GO:0072372) 4.642SMO, PTCH1
organelle membrane (GO:0031090) 1.972SMO, PTCH1
whole membrane (GO:0098805) 2.852SMO, PTCH1
cytoplasmic vesicle part (GO:0044433) 3.412SMO, PTCH1
Golgi apparatus (GO:0005794) 2.72SMO, PTCH1
bounding membrane of organelle (GO:0098588) 2.392SMO, PTCH1
membrane region (GO:0098589) 3.952SMO, PTCH1
cell projection membrane (GO:0031253) 4.112SMO, PTCH1
cytoplasmic vesicle membrane (GO:0030659) 3.672SMO, PTCH1
endocytic vesicle membrane (GO:0030666) 4.822SMO, PTCH1
vesicle membrane (GO:0012506) 3.632SMO, PTCH1
intracellular membrane-bounded organelle (GO:0043231) 0.62SMO, PTCH1
membrane raft (GO:0045121) 4.182SMO, PTCH1
intracellular organelle part (GO:0044446) 0.812SMO, PTCH1
ciliary part (GO:0044441) 4.052SMO, PTCH1
membrane microdomain (GO:0098857) 4.172SMO, PTCH1
organelle part (GO:0044422) 0.792SMO, PTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
cell projection (GO:0042995) -2.470.042RASA1, SMO, PTCH1
primary cilium (GO:0072372) -4.640.009SMO, PTCH1