Disease table of MEDULLOBLASTOMA OMIM ID: 155255

Gene-disease associations table

GeneAssociated with MEDULLOBLASTOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CTNNB1ClinVar, HUMSAVARHGNC link3p22.16114550, 155255, 167000, PS156200, 114500, 132600
APCHUMSAVARHGNC link5q22.26114550, PS175100, 155255, 135290, 114500, 613659
BRCA2ClinVar, OMIMHGNC link13q13.18PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
PTCH2OMIMHGNC link1p34.13605462, 109400, 155255
SUFUClinVar, OMIMHGNC link10q24.323607174, 155255, 109400

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
CTNNB1YES20PTGS2, BIRC5, PPARD, CHGA, TCF7, CLDN2, CCND1, GLCE, CD44, GLI2, NRCAM, RB1, MMP14, JUN, SPP1, VIM, MYC, PLD1, MMP7, STARD70
APCYES11PTGS2, NOS2, KLF4, BIRC5, SPP1, DNMT1, AKT1, MYC, AMHR2, ODC1, SGK10
USF2NO42PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC2APC, BRCA2
USF1NO58PF4, FCER1A, CEACAM5, FMO3, ID4, SCN9A, ASCL2, CEACAM1, MYH9, AGT, APOA2, SERPINE1, TBX21, TOP3A, PTGS2, CYP19A1, ISG20, GCK, CTSB, CXCR4, EXT1, TCN2, SLC22A2, TGFB1, PKLR, FMR1, SLC19A1, APC, SLC16A1, TYMS, CCNB1, TGFB2, PIGR, CYP1A1, CTSD, HOXB7, TRAP, IFNG, PTPN6, NPHS2, GATA5, FBP1, S100A6, BRCA2, HOXB4, ABCA1, SERBP1, TERT, ASPH, APOA5, B2M, HMOX1, CD2, CIITA, APEX1, PTGDS, SLC1A3, LIPC2APC, BRCA2
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING12BRCA2, CTNNB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CTNNB1YES8AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT10
APCYES6YY1, USF2, CEBPZ, EZH2, CDX2, USF10
BRCA2YES11ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF10
PTGS2NO41AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF12APC, CTNNB1
BIRC5NO25ILF3, E2F4, TP53, TCF7L2, SP1, TCF4, NFKB1, KLF4, DNMT1, CTNNB1, FOXO3, APC, LEF1, HDAC1, RELA, EP300, E2F1, STAT3, SP4, EHMT2, RB1, SP3, TP73, KLF5, MYCN2APC, CTNNB1
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A2APC, CTNNB1
SPP1NO23POU2F1, ETS2, TFCP2, TBX21, POU5F1, SP1, ETV4, CEBPA, FOXD3, ETS1, CTNNB1, HTATIP2, ESRRA, APC, LEF1, VDR, HDAC1, ERG, JUN, ING4, EP300, POU2F2, NR3C12APC, CTNNB1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CTNNB1APCYes32LATS2, DLGAP1, STRN3, XPO1, SIAH1, BTRC, CTBP1, MUC1, ERBB2IP, NHSL1, CEP128, MAPRE1, AXIN1, COPS5, CTNNA1, NUP153, FBXW11, APC, SFN, APC2, JUP, AXIN2, TFAP2A, AP2M1, EPAS1, GSK3B, AMER1, CREBBP, DVL2, HNRNPM, NUP98, RANBP2
CTNNB1BRCA2No9SP1, KAT2B, CDK2, SMAD2, FANCG, SMAD3, PLK1, BRCA1, CCNA2
APCBRCA2No4FLNA, BUB1B, SMC3, PCNA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CTNNB1APCNo1KCTD1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CTNNB1BRCA2No-7AR, HIST3H3, CDK2, PLK1, SNAI2, SMAD3, BRCA1
CTNNB1PTCH2No-2GLI1, BMP4
CTNNB1SUFUNo-3HDAC1, HDAC2, GLI1
BRCA2SUFUNo-1TP53
PTCH2SUFUNo-4SMO, GLI3, GLI2, GLI1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
CTNNB1APCYesAXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex2AXIN1, GSK3B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CTNNB1APCYes2APC, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
PTCH2SUFUmaybe, indirectSUFU ia negative regulator in the hedgehog signaling pathway, in which PTCH2 has a role. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.985APC, PTCH2, BRCA2, SUFU, CTNNB1
Basal cell carcinomahsa052176.794APC, PTCH2, SUFU, CTNNB1
Signaling pathways regulating pluripotency of stem cellshsa045505.62APC, CTNNB1
Hedgehog signaling pathwayhsa043407.012PTCH2, SUFU
Endometrial cancerhsa052136.812APC, CTNNB1
Colorectal cancerhsa052106.522APC, CTNNB1
Hippo signaling pathwayhsa043905.372APC, CTNNB1
HTLV-I infectionhsa051664.592APC, CTNNB1
Wnt signaling pathwayhsa043105.492APC, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
Cancers: OverviewNEW2.720.004APC, PTCH2, BRCA2, SUFU, CTNNB1
Hedgehog signaling pathway (hsa04340) -7.010.026PTCH2, SUFU, CTNNB1
Endometrial cancer (hsa05213) -6.810.034APC, CTNNB1
Pathways in cancer (hsa05200) -3.980.0APC, PTCH2, BRCA2, SUFU, CTNNB1
Basal cell carcinoma (hsa05217) -6.790.0APC, PTCH2, SUFU, CTNNB1
Cancers: Specific typesNEW4.10.0APC, PTCH2, BRCA2, SUFU, CTNNB1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.784APC, PTCH2, SUFU, CTNNB1
T41 mutants of beta-catenin aren't phosphorylatedR-HSA-53587529.082APC, CTNNB1
S45 mutants of beta-catenin aren't phosphorylatedR-HSA-53587519.082APC, CTNNB1
misspliced GSK3beta mutants stabilize beta-cateninR-HSA-53397169.082APC, CTNNB1
S33 mutants of beta-catenin aren't phosphorylatedR-HSA-53587479.082APC, CTNNB1
Diseases of signal transductionR-HSA-56632024.892APC, CTNNB1
Apoptotic cleavage of cellular proteinsR-HSA-1114657.732APC, CTNNB1
Degradation of beta-catenin by the destruction complexR-HSA-1952536.642APC, CTNNB1
Signaling by WNT in cancerR-HSA-47912757.892APC, CTNNB1
Beta-catenin phosphorylation cascadeR-HSA-1962998.892APC, CTNNB1
Apoptotic execution phaseR-HSA-751537.282APC, CTNNB1
S37 mutants of beta-catenin aren't phosphorylatedR-HSA-53587499.082APC, CTNNB1
Programmed Cell DeathR-HSA-53578015.652APC, CTNNB1
Signaling by WntR-HSA-1957214.792APC, CTNNB1
ApoptosisR-HSA-1095815.682APC, CTNNB1
deactivation of the beta-catenin transactivating complexR-HSA-37694027.592APC, CTNNB1
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexR-HSA-48397439.082APC, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.032APC, CTNNB1
TCF dependent signaling in response to WNTR-HSA-2016815.362APC, CTNNB1
DiseaseR-HSA-16436853.332APC, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
T41 mutants of beta-catenin aren't phosphorylated (R-HSA-5358752) -9.080.002APC, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262) -8.030.01APC, CTNNB1
S45 mutants of beta-catenin aren't phosphorylated (R-HSA-5358751) -9.080.002APC, CTNNB1
misspliced GSK3beta mutants stabilize beta-catenin (R-HSA-5339716) -9.080.002APC, CTNNB1
S33 mutants of beta-catenin aren't phosphorylated (R-HSA-5358747) -9.080.002APC, CTNNB1
Apoptotic cleavage of cellular proteins (R-HSA-111465) -7.730.016APC, CTNNB1
Signaling by WNT in cancer (R-HSA-4791275) -7.890.023APC, CTNNB1
Beta-catenin phosphorylation cascade (R-HSA-196299) -8.890.003APC, CTNNB1
Apoptotic execution phase (R-HSA-75153) -7.280.03APC, CTNNB1
S37 mutants of beta-catenin aren't phosphorylated (R-HSA-5358749) -9.080.002APC, CTNNB1
deactivation of the beta-catenin transactivating complex (R-HSA-3769402) -7.590.019APC, CTNNB1
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex (R-HSA-4839743) -9.080.002APC, CTNNB1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185APC, PTCH2, BRCA2, SUFU, CTNNB1
protein binding (GO:0005515) 0.465APC, PTCH2, BRCA2, SUFU, CTNNB1
enzyme binding (GO:0019899) 2.274APC, SUFU, BRCA2, CTNNB1
protein kinase binding (GO:0019901) 3.443APC, SUFU, CTNNB1
kinase binding (GO:0019900) 3.323APC, SUFU, CTNNB1
signal transducer activity (GO:0004871) 2.283PTCH2, SUFU, CTNNB1
tubulin binding (GO:0015631) 4.12APC, BRCA2
transcription factor activity, transcription factor binding (GO:0000989) 3.362SUFU, CTNNB1
cytoskeletal protein binding (GO:0008092) 3.022APC, BRCA2
organic cyclic compound binding (GO:0097159) 1.052BRCA2, CTNNB1
transcription factor binding (GO:0008134) 3.462SUFU, CTNNB1
transcription factor activity, protein binding (GO:0000988) 3.352SUFU, CTNNB1
transcription cofactor activity (GO:0003712) 3.442SUFU, CTNNB1
beta-catenin binding (GO:0008013) 5.32APC, SUFU
macromolecular complex binding (GO:0044877) 2.612APC, CTNNB1
cadherin binding (GO:0045296) 6.412APC, CTNNB1
nucleic acid binding (GO:0003676) 1.442BRCA2, CTNNB1
DNA binding (GO:0003677) 1.922BRCA2, CTNNB1
protein complex binding (GO:0032403) 3.092APC, CTNNB1
receptor binding (GO:0005102) 2.432PTCH2, CTNNB1
cell adhesion molecule binding (GO:0050839) 4.52APC, CTNNB1
heterocyclic compound binding (GO:1901363) 1.062BRCA2, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
gamma-catenin binding (GO:0045295) NEW7.170.003APC, CTNNB1
enzyme binding (GO:0019899) -2.270.012APC, SUFU, BRCA2, CTNNB1
protein kinase binding (GO:0019901) -3.440.01APC, SUFU, CTNNB1
kinase binding (GO:0019900) -3.320.014APC, SUFU, CTNNB1
beta-catenin binding (GO:0008013) -5.30.012APC, SUFU, CTNNB1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.365APC, PTCH2, BRCA2, SUFU, CTNNB1
multicellular organismal process (GO:0032501) 1.455APC, PTCH2, BRCA2, SUFU, CTNNB1
single-multicellular organism process (GO:0044707) 1.785APC, PTCH2, BRCA2, SUFU, CTNNB1
anatomical structure development (GO:0048856) 1.585APC, PTCH2, BRCA2, SUFU, CTNNB1
regulation of cellular process (GO:0050794) 0.55APC, PTCH2, BRCA2, SUFU, CTNNB1
biological regulation (GO:0065007) 0.395APC, PTCH2, BRCA2, SUFU, CTNNB1
animal organ development (GO:0048513) 2.535APC, PTCH2, BRCA2, SUFU, CTNNB1
single-organism cellular process (GO:0044763) 0.655APC, PTCH2, BRCA2, SUFU, CTNNB1
negative regulation of cellular process (GO:0048523) 1.415APC, PTCH2, BRCA2, SUFU, CTNNB1
negative regulation of biological process (GO:0048519) 1.335APC, PTCH2, BRCA2, SUFU, CTNNB1
cellular process (GO:0009987) 0.265APC, PTCH2, BRCA2, SUFU, CTNNB1
regulation of biological process (GO:0050789) 0.455APC, PTCH2, BRCA2, SUFU, CTNNB1
single-organism process (GO:0044699) 0.485APC, PTCH2, BRCA2, SUFU, CTNNB1
signal transduction (GO:0007165) 1.285APC, PTCH2, BRCA2, SUFU, CTNNB1
negative regulation of metabolic process (GO:0009892) 1.934APC, SUFU, BRCA2, CTNNB1
metabolic process (GO:0008152) 0.584APC, SUFU, BRCA2, CTNNB1
regulation of metabolic process (GO:0019222) 1.024APC, SUFU, BRCA2, CTNNB1
negative regulation of response to stimulus (GO:0048585) 2.524APC, PTCH2, SUFU, CTNNB1
negative regulation of cellular metabolic process (GO:0031324) 2.014APC, SUFU, BRCA2, CTNNB1
regulation of response to stimulus (GO:0048583) 1.544APC, PTCH2, SUFU, CTNNB1
negative regulation of signaling (GO:0023057) 2.654APC, PTCH2, SUFU, CTNNB1
negative regulation of cell communication (GO:0010648) 2.664APC, PTCH2, SUFU, CTNNB1
regulation of signaling (GO:0023051) 1.724APC, PTCH2, SUFU, CTNNB1
regulation of cell communication (GO:0010646) 1.734APC, PTCH2, SUFU, CTNNB1
regulation of primary metabolic process (GO:0080090) 1.084APC, SUFU, BRCA2, CTNNB1
negative regulation of macromolecule metabolic process (GO:0010605) 2.014APC, SUFU, BRCA2, CTNNB1
negative regulation of signal transduction (GO:0009968) 2.754APC, PTCH2, SUFU, CTNNB1
regulation of signal transduction (GO:0009966) 1.844APC, PTCH2, SUFU, CTNNB1
cellular developmental process (GO:0048869) 1.824APC, PTCH2, BRCA2, CTNNB1
organic substance metabolic process (GO:0071704) 0.634APC, SUFU, BRCA2, CTNNB1
positive regulation of biological process (GO:0048518) 1.24APC, PTCH2, BRCA2, CTNNB1
regulation of macromolecule metabolic process (GO:0060255) 1.084APC, SUFU, BRCA2, CTNNB1
regulation of cellular metabolic process (GO:0031323) 1.074APC, SUFU, BRCA2, CTNNB1
single-organism developmental process (GO:0044767) 1.494APC, SUFU, BRCA2, CTNNB1
regulation of cell differentiation (GO:0045595) 2.424APC, PTCH2, SUFU, CTNNB1
regulation of nitrogen compound metabolic process (GO:0051171) 1.364APC, SUFU, BRCA2, CTNNB1
regulation of multicellular organismal process (GO:0051239) 1.874PTCH2, BRCA2, SUFU, CTNNB1
primary metabolic process (GO:0044238) 0.694APC, SUFU, BRCA2, CTNNB1
protein metabolic process (GO:0019538) 1.454APC, SUFU, BRCA2, CTNNB1
regulation of developmental process (GO:0050793) 2.14PTCH2, BRCA2, SUFU, CTNNB1
macromolecule metabolic process (GO:0043170) 0.834APC, SUFU, BRCA2, CTNNB1
regulation of multicellular organismal development (GO:2000026) 2.314PTCH2, BRCA2, SUFU, CTNNB1
positive regulation of cellular process (GO:0048522) 1.34APC, PTCH2, BRCA2, CTNNB1
positive regulation of metabolic process (GO:0009893) 1.743APC, BRCA2, CTNNB1
negative regulation of biosynthetic process (GO:0009890) 2.473SUFU, BRCA2, CTNNB1
regulation of cell cycle process (GO:0010564) 3.53APC, BRCA2, CTNNB1
macromolecular complex subunit organization (GO:0043933) 2.143APC, BRCA2, CTNNB1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463SUFU, BRCA2, CTNNB1
cell surface receptor signaling pathway (GO:0007166) 2.093APC, SUFU, CTNNB1
negative regulation of protein modification process (GO:0031400) 3.43APC, SUFU, CTNNB1
multicellular organism development (GO:0007275) 2.543SUFU, BRCA2, CTNNB1
cellular component organization or biogenesis (GO:0071840) 1.223APC, BRCA2, CTNNB1
pattern specification process (GO:0007389) 3.793APC, SUFU, CTNNB1
cellular response to stimulus (GO:0051716) 1.973APC, BRCA2, CTNNB1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813APC, BRCA2, CTNNB1
cellular macromolecule metabolic process (GO:0044260) 0.933APC, BRCA2, CTNNB1
cell fate specification (GO:0001708) 5.573APC, PTCH2, CTNNB1
negative regulation of multicellular organismal process (GO:0051241) 2.843SUFU, BRCA2, CTNNB1
regulation of protein metabolic process (GO:0051246) 1.933APC, SUFU, CTNNB1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63SUFU, BRCA2, CTNNB1
cellular component organization (GO:0016043) 1.243APC, BRCA2, CTNNB1
localization (GO:0051179) 1.43SUFU, BRCA2, CTNNB1
negative regulation of developmental process (GO:0051093) 3.173SUFU, BRCA2, CTNNB1
negative regulation of cellular biosynthetic process (GO:0031327) 2.493SUFU, BRCA2, CTNNB1
regulation of protein modification process (GO:0031399) 2.323APC, SUFU, CTNNB1
proteolysis (GO:0006508) 2.733APC, SUFU, CTNNB1
regulation of molecular function (GO:0065009) 1.783APC, SUFU, CTNNB1
regulation of biological quality (GO:0065008) 1.683SUFU, BRCA2, CTNNB1
regulation of gene expression (GO:0010468) 1.373SUFU, BRCA2, CTNNB1
skin development (GO:0043588) 5.843PTCH2, SUFU, CTNNB1
regulation of cell proliferation (GO:0042127) 2.413APC, BRCA2, CTNNB1
negative regulation of cell proliferation (GO:0008285) 3.263APC, BRCA2, CTNNB1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553SUFU, BRCA2, CTNNB1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433SUFU, BRCA2, CTNNB1
regulation of biosynthetic process (GO:0009889) 1.373SUFU, BRCA2, CTNNB1
regulation of mitotic cell cycle (GO:0007346) 3.713APC, BRCA2, CTNNB1
regulation of nucleic acid-templated transcription (GO:1903506) 1.553SUFU, BRCA2, CTNNB1
regulation of cellular biosynthetic process (GO:0031326) 1.383SUFU, BRCA2, CTNNB1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473SUFU, BRCA2, CTNNB1
regulation of RNA biosynthetic process (GO:2001141) 1.553SUFU, BRCA2, CTNNB1
response to chemical (GO:0042221) 1.983APC, BRCA2, CTNNB1
regulation of localization (GO:0032879) 1.943APC, SUFU, CTNNB1
response to organic substance (GO:0010033) 2.23APC, BRCA2, CTNNB1
response to oxygen-containing compound (GO:1901700) 2.573APC, BRCA2, CTNNB1
negative regulation of cellular protein metabolic process (GO:0032269) 2.883APC, SUFU, CTNNB1
regulation of cellular protein metabolic process (GO:0032268) 1.993APC, SUFU, CTNNB1
regulation of cell cycle (GO:0051726) 2.933APC, BRCA2, CTNNB1
response to stimulus (GO:0050896) 1.223APC, BRCA2, CTNNB1
regulation of RNA metabolic process (GO:0051252) 1.523SUFU, BRCA2, CTNNB1
cellular metabolic process (GO:0044237) 0.693APC, BRCA2, CTNNB1
regulation of transcription, DNA-templated (GO:0006355) 1.563SUFU, BRCA2, CTNNB1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433SUFU, BRCA2, CTNNB1
negative regulation of protein metabolic process (GO:0051248) 2.823APC, SUFU, CTNNB1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533SUFU, BRCA2, CTNNB1
regulation of smoothened signaling pathway (GO:0008589) 5.622PTCH2, SUFU
regulation of phosphate metabolic process (GO:0019220) 2.352APC, CTNNB1
anatomical structure homeostasis (GO:0060249) 4.252BRCA2, CTNNB1
regulation of transport (GO:0051049) 2.242SUFU, CTNNB1
cell maturation (GO:0048469) 4.982BRCA2, CTNNB1
skeletal system development (GO:0001501) 4.492SUFU, CTNNB1
organic cyclic compound biosynthetic process (GO:1901362) 1.662BRCA2, CTNNB1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792APC, CTNNB1
organic cyclic compound metabolic process (GO:1901360) 1.262BRCA2, CTNNB1
negative regulation of cell cycle (GO:0045786) 3.672APC, CTNNB1
regulation of cytoskeleton organization (GO:0051493) 3.722APC, CTNNB1
response to growth factor (GO:0070848) 4.142APC, CTNNB1
regulation of osteoblast differentiation (GO:0045667) 4.992SUFU, CTNNB1
regulation of epithelial cell differentiation (GO:0030856) 4.962PTCH2, CTNNB1
negative regulation of molecular function (GO:0044092) 2.742APC, SUFU
positive regulation of epithelial cell differentiation (GO:0030858) 5.762PTCH2, CTNNB1
cytokinesis (GO:0000910) 5.222APC, BRCA2
regulation of DNA metabolic process (GO:0051052) 3.872BRCA2, CTNNB1
establishment of protein localization (GO:0045184) 2.532BRCA2, CTNNB1
developmental process involved in reproduction (GO:0003006) 3.362BRCA2, CTNNB1
regionalization (GO:0003002) 4.242SUFU, CTNNB1
regulation of embryonic development (GO:0045995) 4.982SUFU, CTNNB1
cellular response to growth factor stimulus (GO:0071363) 4.272APC, CTNNB1
tube formation (GO:0035148) 4.982SUFU, CTNNB1
heterocycle metabolic process (GO:0046483) 1.312BRCA2, CTNNB1
regulation of phosphorylation (GO:0042325) 2.52APC, CTNNB1
cellular catabolic process (GO:0044248) 2.622APC, CTNNB1
single organism reproductive process (GO:0044702) 2.732BRCA2, CTNNB1
response to external stimulus (GO:0009605) 2.552BRCA2, CTNNB1
cell motility (GO:0048870) 3.022APC, CTNNB1
Wnt signaling pathway (GO:0016055) 3.882APC, CTNNB1
cellular nitrogen compound metabolic process (GO:0034641) 1.222BRCA2, CTNNB1
cellular response to stress (GO:0033554) 2.512APC, BRCA2
aromatic compound biosynthetic process (GO:0019438) 1.72BRCA2, CTNNB1
regulation of microtubule cytoskeleton organization (GO:0070507) 4.982APC, CTNNB1
regulation of catabolic process (GO:0009894) 3.522APC, SUFU
cellular component assembly (GO:0022607) 2.142APC, CTNNB1
cellular macromolecule biosynthetic process (GO:0034645) 1.662BRCA2, CTNNB1
positive regulation of biosynthetic process (GO:0009891) 2.292BRCA2, CTNNB1
movement of cell or subcellular component (GO:0006928) 2.612APC, CTNNB1
negative regulation of gene expression (GO:0010629) 2.482SUFU, CTNNB1
positive regulation of gene expression (GO:0010628) 2.352BRCA2, CTNNB1
negative regulation of RNA biosynthetic process (GO:1902679) 2.72SUFU, CTNNB1
regulation of apoptotic process (GO:0042981) 2.52APC, CTNNB1
organic substance biosynthetic process (GO:1901576) 1.342BRCA2, CTNNB1
organic substance catabolic process (GO:1901575) 2.452APC, CTNNB1
cellular macromolecule catabolic process (GO:0044265) 3.192APC, CTNNB1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242SUFU, CTNNB1
macromolecular complex assembly (GO:0065003) 2.552APC, CTNNB1
cell migration (GO:0016477) 3.122APC, CTNNB1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012SUFU, CTNNB1
heterocycle biosynthetic process (GO:0018130) 1.72BRCA2, CTNNB1
positive regulation of cellular component organization (GO:0051130) 2.682APC, CTNNB1
beta-catenin destruction complex disassembly (GO:1904886) 6.642APC, CTNNB1
regulation of catalytic activity (GO:0050790) 1.972APC, CTNNB1
tissue development (GO:0009888) 3.272PTCH2, CTNNB1
negative regulation of smoothened signaling pathway (GO:0045879) 6.552PTCH2, SUFU
canonical Wnt signaling pathway (GO:0060070) 5.262APC, CTNNB1
response to stress (GO:0006950) 1.82APC, BRCA2
hemopoiesis (GO:0030097) 5.072BRCA2, CTNNB1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722BRCA2, CTNNB1
regulation of ossification (GO:0030278) 4.532SUFU, CTNNB1
establishment of localization (GO:0051234) 1.482BRCA2, CTNNB1
positive regulation of cell differentiation (GO:0045597) 3.012PTCH2, CTNNB1
proteolysis involved in cellular protein catabolic process (GO:0051603) 3.592APC, CTNNB1
dorsal/ventral pattern formation (GO:0009953) 5.62SUFU, CTNNB1
proteasomal protein catabolic process (GO:0010498) 4.122APC, CTNNB1
regulation of transferase activity (GO:0051338) 2.882APC, CTNNB1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392BRCA2, CTNNB1
regulation of nervous system development (GO:0051960) 3.12SUFU, CTNNB1
response to alcohol (GO:0097305) 4.582APC, CTNNB1
regulation of chromosome organization (GO:0033044) 4.112APC, CTNNB1
regulation of sister chromatid segregation (GO:0033045) 5.632APC, CTNNB1
regulation of organelle organization (GO:0033043) 2.722APC, CTNNB1
pancreas development (GO:0031016) 6.472APC, CTNNB1
negative regulation of cellular component organization (GO:0051129) 3.352APC, CTNNB1
regulation of cellular component organization (GO:0051128) 2.012APC, CTNNB1
regulation of cellular protein localization (GO:1903827) 3.432SUFU, CTNNB1
embryo development (GO:0009790) 4.22BRCA2, CTNNB1
regulation of protein catabolic process (GO:0042176) 3.832APC, SUFU
embryo development ending in birth or egg hatching (GO:0009792) 4.352BRCA2, CTNNB1
cellular response to chemical stimulus (GO:0070887) 2.572APC, CTNNB1
regulation of microtubule-based process (GO:0032886) 4.792APC, CTNNB1
anatomical structure morphogenesis (GO:0009653) 2.532SUFU, CTNNB1
protein complex disassembly (GO:0043241) 4.582APC, CTNNB1
response to organic cyclic compound (GO:0014070) 3.072BRCA2, CTNNB1
regulation of protein localization (GO:0032880) 2.882SUFU, CTNNB1
response to endogenous stimulus (GO:0009719) 2.792APC, CTNNB1
nucleobase-containing compound metabolic process (GO:0006139) 1.352BRCA2, CTNNB1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122SUFU, CTNNB1
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 4.162APC, CTNNB1
cell fate determination (GO:0001709) 5.972PTCH2, CTNNB1
positive regulation of protein metabolic process (GO:0051247) 2.432APC, CTNNB1
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.142SUFU, CTNNB1
negative regulation of protein modification by small protein conjugation or removal (GO:1903321) 4.82SUFU, CTNNB1
epithelial tube morphogenesis (GO:0060562) 5.122SUFU, CTNNB1
chordate embryonic development (GO:0043009) 4.382BRCA2, CTNNB1
biological adhesion (GO:0022610) 2.812APC, CTNNB1
cellular response to endogenous stimulus (GO:0071495) 3.332APC, CTNNB1
reproductive structure development (GO:0048608) 4.082BRCA2, CTNNB1
cell proliferation (GO:0008283) 3.232BRCA2, CTNNB1
establishment of protein localization to organelle (GO:0072594) 3.922BRCA2, CTNNB1
modification-dependent protein catabolic process (GO:0019941) 3.712APC, CTNNB1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712SUFU, CTNNB1
cellular response to DNA damage stimulus (GO:0006974) 3.172APC, BRCA2
negative regulation of cell differentiation (GO:0045596) 3.332SUFU, CTNNB1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752SUFU, CTNNB1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562BRCA2, CTNNB1
cell-cell junction organization (GO:0045216) 4.662APC, CTNNB1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592BRCA2, CTNNB1
cell junction assembly (GO:0034329) 4.862APC, CTNNB1
regulation of chromosome segregation (GO:0051983) 5.382APC, CTNNB1
nucleic acid metabolic process (GO:0090304) 1.462BRCA2, CTNNB1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832SUFU, CTNNB1
regulation of epithelial cell proliferation (GO:0050678) 4.062BRCA2, CTNNB1
positive regulation of developmental process (GO:0051094) 2.772PTCH2, CTNNB1
negative regulation of RNA metabolic process (GO:0051253) 2.662SUFU, CTNNB1
response to drug (GO:0042493) 3.712APC, CTNNB1
positive regulation of RNA metabolic process (GO:0051254) 2.512BRCA2, CTNNB1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542BRCA2, CTNNB1
nitrogen compound metabolic process (GO:0006807) 1.132BRCA2, CTNNB1
system development (GO:0048731) 2.922SUFU, CTNNB1
gland development (GO:0048732) 4.152BRCA2, CTNNB1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562BRCA2, CTNNB1
regulation of cellular localization (GO:0060341) 3.032SUFU, CTNNB1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32BRCA2, CTNNB1
positive regulation of cellular metabolic process (GO:0031325) 1.812BRCA2, CTNNB1
cell junction organization (GO:0034330) 4.512APC, CTNNB1
homeostatic process (GO:0042592) 2.612BRCA2, CTNNB1
cell cycle process (GO:0022402) 2.752APC, BRCA2
positive regulation of cellular component biogenesis (GO:0044089) 3.712APC, CTNNB1
positive regulation of cell death (GO:0010942) 3.322APC, CTNNB1
tube morphogenesis (GO:0035239) 4.352SUFU, CTNNB1
modification-dependent macromolecule catabolic process (GO:0043632) 3.692APC, CTNNB1
regulation of cell death (GO:0010941) 2.432APC, CTNNB1
morphogenesis of an epithelium (GO:0002009) 4.082SUFU, CTNNB1
response to estradiol (GO:0032355) 4.732BRCA2, CTNNB1
protein complex subunit organization (GO:0071822) 2.62APC, CTNNB1
chromatin organization (GO:0006325) 3.282BRCA2, CTNNB1
response to lipid (GO:0033993) 3.112BRCA2, CTNNB1
negative regulation of nervous system development (GO:0051961) 4.152SUFU, CTNNB1
regulation of programmed cell death (GO:0043067) 2.492APC, CTNNB1
positive regulation of apoptotic process (GO:0043065) 3.382APC, CTNNB1
cellular response to organic substance (GO:0071310) 2.782APC, CTNNB1
ubiquitin-dependent protein catabolic process (GO:0006511) 3.722APC, CTNNB1
tissue morphogenesis (GO:0048729) 3.872SUFU, CTNNB1
hematopoietic or lymphoid organ development (GO:0048534) 4.492BRCA2, CTNNB1
positive regulation of programmed cell death (GO:0043068) 3.382APC, CTNNB1
embryonic morphogenesis (GO:0048598) 3.722SUFU, CTNNB1
negative regulation of mitotic cell cycle (GO:0045930) 4.452APC, CTNNB1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352BRCA2, CTNNB1
cellular aromatic compound metabolic process (GO:0006725) 1.32BRCA2, CTNNB1
protein complex assembly (GO:0006461) 2.782APC, CTNNB1
macromolecular complex disassembly (GO:0032984) 4.532APC, CTNNB1
regulation of phosphorus metabolic process (GO:0051174) 2.352APC, CTNNB1
reproductive process (GO:0022414) 2.552BRCA2, CTNNB1
biosynthetic process (GO:0009058) 1.322BRCA2, CTNNB1
macromolecule biosynthetic process (GO:0009059) 1.612BRCA2, CTNNB1
cellular component disassembly (GO:0022411) 3.522APC, CTNNB1
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32BRCA2, CTNNB1
cell adhesion (GO:0007155) 2.822APC, CTNNB1
catabolic process (GO:0009056) 2.382APC, CTNNB1
macromolecule catabolic process (GO:0009057) 3.02APC, CTNNB1
single-organism localization (GO:1902578) 2.092SUFU, CTNNB1
locomotion (GO:0040011) 2.912APC, CTNNB1
response to abiotic stimulus (GO:0009628) 2.82BRCA2, CTNNB1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292BRCA2, CTNNB1
negative regulation of embryonic development (GO:0045992) 6.472SUFU, CTNNB1
regulation of cellular component biogenesis (GO:0044087) 3.082APC, CTNNB1
developmental maturation (GO:0021700) 4.72BRCA2, CTNNB1
regulation of protein phosphorylation (GO:0001932) 2.572APC, CTNNB1
cellular biosynthetic process (GO:0044249) 1.372BRCA2, CTNNB1
protein catabolic process (GO:0030163) 3.932APC, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of smoothened signaling pathway (GO:0008589) -5.620.01PTCH2, SUFU, CTNNB1
negative regulation of response to stimulus (GO:0048585) -2.520.043APC, PTCH2, SUFU, CTNNB1
negative regulation of signaling (GO:0023057) -2.650.025APC, PTCH2, SUFU, CTNNB1
regulation of protein catabolic process (GO:0042176) -3.830.018APC, SUFU, BRCA2, CTNNB1
negative regulation of cell communication (GO:0010648) -2.660.025APC, PTCH2, SUFU, CTNNB1
regulation of sister chromatid cohesion (GO:0007063) NEW6.90.028APC, CTNNB1
negative regulation of signal transduction (GO:0009968) -2.750.021APC, PTCH2, SUFU, CTNNB1
negative regulation of protein modification by small protein conjugation or removal (GO:1903321) -4.80.014SUFU, BRCA2, CTNNB1
regulation of osteoblast differentiation (GO:0045667) -4.990.002APC, SUFU, CTNNB1
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336) NEW8.630.0APC, CTNNB1
thymus development (GO:0048538) NEW5.880.038APC, CTNNB1
positive regulation of epithelial cell differentiation (GO:0030858) -5.760.042APC, CTNNB1
T cell differentiation in thymus (GO:0033077) NEW6.330.026APC, CTNNB1
epithelium development (GO:0060429) NEW4.570.02APC, PTCH2, CTNNB1
negative regulation of smoothened signaling pathway (GO:0045879) -6.550.0PTCH2, SUFU, CTNNB1
regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) NEW7.530.002APC, CTNNB1
regulation of ossification (GO:0030278) -4.530.007APC, SUFU, CTNNB1
hematopoietic or lymphoid organ development (GO:0048534) -4.490.006APC, BRCA2, CTNNB1
regulation of chromosome segregation (GO:0051983) -5.380.023APC, CTNNB1
proximal/distal pattern formation (GO:0009954) NEW6.430.013APC, CTNNB1
regulation of epithelial cell proliferation (GO:0050678) -4.060.021APC, BRCA2, CTNNB1
anatomical structure development (GO:0048856) -1.580.05APC, PTCH2, BRCA2, SUFU, CTNNB1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.014APC, SUFU, BRCA2, CTNNB1
intracellular organelle part (GO:0044446) 0.814APC, SUFU, BRCA2, CTNNB1
intracellular membrane-bounded organelle (GO:0043231) 0.64APC, SUFU, BRCA2, CTNNB1
nucleus (GO:0005634) 1.074APC, SUFU, BRCA2, CTNNB1
membrane (GO:0016020) 0.684APC, PTCH2, BRCA2, CTNNB1
cell part (GO:0044464) 0.114APC, SUFU, BRCA2, CTNNB1
cytoplasmic part (GO:0044444) 0.824APC, SUFU, BRCA2, CTNNB1
nucleoplasm (GO:0005654) 1.894APC, SUFU, BRCA2, CTNNB1
intracellular organelle (GO:0043229) 0.514APC, SUFU, BRCA2, CTNNB1
nuclear part (GO:0044428) 1.554APC, SUFU, BRCA2, CTNNB1
intracellular part (GO:0044424) 0.284APC, SUFU, BRCA2, CTNNB1
membrane part (GO:0044425) 0.954APC, PTCH2, BRCA2, CTNNB1
membrane-bounded organelle (GO:0043227) 0.474APC, SUFU, BRCA2, CTNNB1
organelle (GO:0043226) 0.44APC, SUFU, BRCA2, CTNNB1
organelle part (GO:0044422) 0.794APC, SUFU, BRCA2, CTNNB1
protein complex (GO:0043234) 1.513APC, BRCA2, CTNNB1
cytoskeleton (GO:0005856) 2.553APC, BRCA2, CTNNB1
chromosomal part (GO:0044427) 3.183APC, BRCA2, CTNNB1
macromolecular complex (GO:0032991) 1.353APC, BRCA2, CTNNB1
intracellular non-membrane-bounded organelle (GO:0043232) 1.763APC, BRCA2, CTNNB1
centrosome (GO:0005813) 3.753APC, BRCA2, CTNNB1
cytosol (GO:0005829) 1.683APC, SUFU, CTNNB1
cell projection part (GO:0044463) 2.973APC, SUFU, CTNNB1
microtubule organizing center (GO:0005815) 3.423APC, BRCA2, CTNNB1
non-membrane-bounded organelle (GO:0043228) 1.763APC, BRCA2, CTNNB1
cytoskeletal part (GO:0044430) 2.493APC, BRCA2, CTNNB1
cell projection (GO:0042995) 2.473APC, SUFU, CTNNB1
plasma membrane region (GO:0098590) 2.972APC, CTNNB1
synapse (GO:0045202) 3.582APC, CTNNB1
catenin complex (GO:0016342) 7.612APC, CTNNB1
bicellular tight junction (GO:0005923) 5.092APC, CTNNB1
intrinsic component of membrane (GO:0031224) 1.132PTCH2, BRCA2
vesicle (GO:0031982) 1.642BRCA2, CTNNB1
nuclear chromosome part (GO:0044454) 3.672BRCA2, CTNNB1
integral component of membrane (GO:0016021) 1.142PTCH2, BRCA2
membrane-bounded vesicle (GO:0031988) 1.712BRCA2, CTNNB1
neuron part (GO:0097458) 2.642APC, CTNNB1
beta-catenin destruction complex (GO:0030877) 7.092APC, CTNNB1
cell junction (GO:0030054) 2.752APC, CTNNB1
neuron projection (GO:0043005) 3.122APC, CTNNB1
plasma membrane part (GO:0044459) 1.952APC, CTNNB1
cytoplasmic region (GO:0099568) 4.512APC, CTNNB1
lateral plasma membrane (GO:0016328) 5.892APC, CTNNB1
lamellipodium (GO:0030027) 4.732APC, CTNNB1
occluding junction (GO:0070160) 5.072APC, CTNNB1
anchoring junction (GO:0070161) 3.612APC, CTNNB1
cell projection membrane (GO:0031253) 4.112APC, CTNNB1
cell-cell adherens junction (GO:0005913) 5.812APC, CTNNB1
cell cortex (GO:0005938) 4.782APC, CTNNB1
cell-cell junction (GO:0005911) 3.852APC, CTNNB1
plasma membrane (GO:0005886) 1.392APC, CTNNB1
Wnt signalosome (GO:1990909) 7.42APC, CTNNB1
plasma membrane protein complex (GO:0098797) 3.552APC, CTNNB1
membrane protein complex (GO:0098796) 2.842APC, CTNNB1
adherens junction (GO:0005912) 3.662APC, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
mitotic spindle (GO:0072686) NEW6.090.01APC, CTNNB1
lateral plasma membrane (GO:0016328) -5.890.004APC, CTNNB1
lamellipodium (GO:0030027) -4.730.043APC, CTNNB1
centrosome (GO:0005813) -3.750.006APC, BRCA2, CTNNB1
occluding junction (GO:0070160) -5.070.03APC, CTNNB1
axonal growth cone (GO:0044295) NEW6.810.003APC, CTNNB1
microtubule organizing center (GO:0005815) -3.420.017APC, BRCA2, CTNNB1
beta-catenin destruction complex (GO:0030877) -7.090.0APC, CTNNB1
tight junction (GO:0005923) -5.090.03APC, CTNNB1