Gene | Associated with DIAMOND-BLACKFAN ANEMIA 15 WITH MANDIBULOFACIAL DYSOSTOSIS in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
RPS26 | ClinVar | HGNC link | 12q13.2 | 2 | PS105650, 606164 |
TSR2 | ClinVar | HGNC link | Xp11.22 | 2 | PS105650, 606164 |
RPS28 | ClinVar, OMIM | HGNC link | 19p13.2 | 1 | 606164 |
Download the disease annotation in CSV format
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
RPS26 | TSR2 | Yes | 1 | BYSL |
RPS26 | RPS28 | Yes | 62 | RPL17, FN1, RPL36, RPL14, RPS19, RPS7, RPS18, RPS8, ILF3, RPS3, RPS12, RPS9, RPS6, RPL19, RPL38, RPS20, WIBG, UBL4A, RPL18, HIST1H3E, RPL21, RPL5, RPS21, RPS15A, MCM2, HNRNPM, RPL6, EED, RPSA, FAU, RPL9, RPS14, RPS15, RPLP0P6, RPL10L, TSR1, RPS16, RPS23, RPS25, RPL10A, RPL4, RPS29, RPL15, RPL23A, RPS17, RPL11, RPL7A, RPL37A, RPL24, RPL12, RPLP2, RPS27, RPS24, RPS10, RPS4X, RPS3A, RPS5, RPL7, RPS13, RPL13, RPL23, RPS2 |
TSR2 | RPS28 | No | 1 | RPS26 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Complexes | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
RPS26 | RPS28 | Yes | 40S ribosomal subunit, cytoplasmic;Ribosome, cytoplasmic | 80 | RPL17, RPL39, RPL18A, RPL14, RPS19, RPS11, RPS10, RPS8, RPS3, RPS12, RPL27, RPL35, RPS25, RPL13A, RPS6, RPL19, RPL38, RPS20, RPL41, RPS4X, RPL18, RPL36A, RPS7, RPL5, RPS21, RPS15A, RPL36, RPL6, RPL8, RPL27A, RPSA, RPL26, RPL3, RPL9, FAU, RPS4Y2, RPS14, UBA52, RPS15, RPL13, RPL37, RPL35A, RPL21, RPL10A, RPS16, RPS23, RPL32, RPL22, RPLP0, RPS27A, RPS17, RPS29, RPL15, RPL23A, RPS4Y1, RPL9; RPL9P7; RPL9P8; RPL9P9, RPL11, RPL7A, RPL37A, RPL23, RPL24, RPL12, RPL31, RPL29, RPL34, RPLP2, RPLP1, RPS27, RPS24, RPS18, RPS9, RPS3A, RPS5, RPL7, RPS13, RPL28, RPL10, RPL4, RPL30, RPS2 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
RPS26 | RPS28 | No | 41 | ILF3, RPS19, RPS8, RPS3, RPS12, RPS4X, RPS6, RPL19, RPS20, RPL18, RPL10A, RPL14, RPL5, RPS21, RPL23, RPL6, RPSA, RPL9, RPS15, RPLP0P6, RPL10L, RPL21, RPS16, RPS23, RPS25, RPS17, RPL15, RPL23A, RPL4, RPL9; RPL9P7; RPL9P8; RPL9P9, RPL11, RPL7A, RPL37A, RPL24, RPL12, RPLP2, RPL17, HNRNPM, RPL7, RPS13, RPS2 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Interaction | Number of common interactors | Common genes in interaction |
---|---|---|---|---|
RPS26 | RPS28 | Yes | 18 | RPL35A, RPS7, RPL21, RPS29, RPS24, RPL5, RPS10, RPS17, RPL15, RPSA, RPL26, RPS26, RPS19, RPL11, EEF2, RPL10, RPS14, RPS28 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct interaction | More information |
---|---|---|---|
RPS26 | TSR2 | yes, they interact | They are in interaction. [UniProt] |
KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Ribosome | hsa03010 | 5.69 | 2 | RPS28, RPS26 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Translation | NEW | 3.91 | 0.023 | RPS28, RPS26 |
Ribosome (hsa03010) | - | 5.69 | 0.001 | RPS28, RPS26 |
REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
SRP-dependent cotranslational protein targeting to membrane | R-HSA-1799339 | 6.24 | 2 | RPS28, RPS26 |
Influenza Infection | R-HSA-168254 | 5.86 | 2 | RPS28, RPS26 |
Influenza Viral RNA Transcription and Replication | R-HSA-168273 | 5.99 | 2 | RPS28, RPS26 |
Formation of a pool of free 40S subunits | R-HSA-72689 | 6.43 | 2 | RPS28, RPS26 |
Disease | R-HSA-1643685 | 3.33 | 2 | RPS28, RPS26 |
Eukaryotic Translation Elongation | R-HSA-156842 | 6.52 | 2 | RPS28, RPS26 |
Translation initiation complex formation | R-HSA-72649 | 7.2 | 2 | RPS28, RPS26 |
Gene Expression | R-HSA-74160 | 2.72 | 2 | RPS28, RPS26 |
Eukaryotic Translation Termination | R-HSA-72764 | 6.59 | 2 | RPS28, RPS26 |
Translation | R-HSA-72766 | 5.8 | 2 | RPS28, RPS26 |
L13a-mediated translational silencing of Ceruloplasmin expression | R-HSA-156827 | 6.28 | 2 | RPS28, RPS26 |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | R-HSA-72662 | 7.18 | 2 | RPS28, RPS26 |
Ribosomal scanning and start codon recognition | R-HSA-72702 | 7.2 | 2 | RPS28, RPS26 |
GTP hydrolysis and joining of the 60S ribosomal subunit | R-HSA-72706 | 6.27 | 2 | RPS28, RPS26 |
Infectious disease | R-HSA-5663205 | 4.47 | 2 | RPS28, RPS26 |
Metabolism of proteins | R-HSA-392499 | 3.41 | 2 | RPS28, RPS26 |
Viral mRNA Translation | R-HSA-192823 | 6.59 | 2 | RPS28, RPS26 |
Influenza Life Cycle | R-HSA-168255 | 5.92 | 2 | RPS28, RPS26 |
Formation of the ternary complex, and subsequently, the 43S complex | R-HSA-72695 | 7.4 | 2 | RPS28, RPS26 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | R-HSA-975957 | 6.25 | 2 | RPS28, RPS26 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | R-HSA-975956 | 6.51 | 2 | RPS28, RPS26 |
Cap-dependent Translation Initiation | R-HSA-72737 | 6.18 | 2 | RPS28, RPS26 |
Peptide chain elongation | R-HSA-156902 | 6.59 | 2 | RPS28, RPS26 |
Nonsense-Mediated Decay (NMD) | R-HSA-927802 | 6.25 | 2 | RPS28, RPS26 |
Eukaryotic Translation Initiation | R-HSA-72613 | 6.18 | 2 | RPS28, RPS26 |
GO | IC | Number of genes with the same GO | Genes |
---|---|---|---|
binding (GO:0005488) | 0.18 | 3 | RPS28, TSR2, RPS26 |
protein binding (GO:0005515) | 0.46 | 3 | RPS28, TSR2, RPS26 |
organic cyclic compound binding (GO:0097159) | 1.05 | 2 | RPS28, RPS26 |
poly(A) RNA binding (GO:0044822) | 2.69 | 2 | RPS28, RPS26 |
structural molecule activity (GO:0005198) | 3.1 | 2 | RPS28, RPS26 |
structural constituent of ribosome (GO:0003735) | 4.32 | 2 | RPS28, RPS26 |
RNA binding (GO:0003723) | 2.36 | 2 | RPS28, RPS26 |
nucleic acid binding (GO:0003676) | 1.44 | 2 | RPS28, RPS26 |
heterocyclic compound binding (GO:1901363) | 1.06 | 2 | RPS28, RPS26 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
structural constituent of ribosome (GO:0003735) | - | 4.32 | 0.004 | RPS28, RPS26 |
structural molecule activity (GO:0005198) | - | 3.1 | 0.049 | RPS28, RPS26 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
cytosolic part (GO:0044445) | - | 4.34 | 0.025 | RPS28, RPS26 |
small ribosomal subunit (GO:0015935) | - | 5.57 | 0.0 | RPS28, RPS26 |
cytosolic small ribosomal subunit (GO:0022627) | - | 6.0 | 0.0 | RPS28, RPS26 |
ribonucleoprotein complex (GO:0030529) | - | 3.19 | 0.036 | RPS28, RPS26 |
ribosomal subunit (GO:0044391) | - | 4.67 | 0.008 | RPS28, RPS26 |