cellular process (GO:0009987) | 0.26 | 14 | MPV17, TK2, SLC25A4, AGK, TYMP, SUCLG1, C10orf2, POLG, SUCLA2, FBXL4, OPA1, DGUOK, RRM2B, MGME1 |
organic substance metabolic process (GO:0071704) | 0.63 | 12 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, FBXL4, AGK, DGUOK, RRM2B, MGME1 |
metabolic process (GO:0008152) | 0.58 | 12 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, FBXL4, AGK, DGUOK, RRM2B, MGME1 |
cellular metabolic process (GO:0044237) | 0.69 | 12 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, FBXL4, AGK, DGUOK, RRM2B, MGME1 |
primary metabolic process (GO:0044238) | 0.69 | 12 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, FBXL4, AGK, DGUOK, RRM2B, MGME1 |
organic substance biosynthetic process (GO:1901576) | 1.34 | 11 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, DGUOK, AGK, RRM2B, MGME1 |
cellular nitrogen compound metabolic process (GO:0034641) | 1.22 | 11 | TK2, SLC25A4, SUCLG1, MGME1, C10orf2, POLG, SUCLA2, DGUOK, AGK, RRM2B, TYMP |
cellular biosynthetic process (GO:0044249) | 1.37 | 11 | TK2, SLC25A4, SUCLG1, MGME1, C10orf2, POLG, SUCLA2, DGUOK, AGK, RRM2B, TYMP |
biosynthetic process (GO:0009058) | 1.32 | 11 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, DGUOK, AGK, RRM2B, MGME1 |
nitrogen compound metabolic process (GO:0006807) | 1.13 | 11 | TK2, SLC25A4, SUCLG1, TYMP, C10orf2, POLG, SUCLA2, DGUOK, AGK, RRM2B, MGME1 |
single-organism process (GO:0044699) | 0.48 | 11 | MPV17, TK2, OPA1, SLC25A4, SUCLG1, TYMP, POLG, SUCLA2, DGUOK, AGK, RRM2B |
single-organism cellular process (GO:0044763) | 0.65 | 10 | MPV17, TK2, SUCLG1, TYMP, POLG, AGK, SUCLA2, DGUOK, OPA1, RRM2B |
cellular nitrogen compound biosynthetic process (GO:0044271) | 1.59 | 9 | TK2, SLC25A4, AGK, TYMP, POLG, SUCLA2, DGUOK, SUCLG1, RRM2B |
cellular macromolecule metabolic process (GO:0044260) | 0.93 | 9 | SLC25A4, TYMP, POLG, C10orf2, FBXL4, TK2, DGUOK, RRM2B, MGME1 |
cellular aromatic compound metabolic process (GO:0006725) | 1.3 | 9 | TK2, TYMP, C10orf2, POLG, SUCLA2, DGUOK, SUCLG1, RRM2B, MGME1 |
macromolecule metabolic process (GO:0043170) | 0.83 | 9 | SLC25A4, MGME1, POLG, C10orf2, FBXL4, TK2, DGUOK, RRM2B, TYMP |
organic cyclic compound metabolic process (GO:1901360) | 1.26 | 9 | TK2, TYMP, C10orf2, POLG, SUCLA2, DGUOK, SUCLG1, RRM2B, MGME1 |
heterocycle metabolic process (GO:0046483) | 1.31 | 9 | TK2, TYMP, C10orf2, POLG, SUCLA2, DGUOK, SUCLG1, RRM2B, MGME1 |
nucleobase-containing compound metabolic process (GO:0006139) | 1.35 | 8 | TK2, TYMP, POLG, C10orf2, DGUOK, SUCLG1, RRM2B, MGME1 |
single-organism metabolic process (GO:0044710) | 1.63 | 7 | TK2, AGK, TYMP, SUCLA2, DGUOK, SUCLG1, RRM2B |
macromolecule biosynthetic process (GO:0009059) | 1.61 | 7 | SLC25A4, TYMP, POLG, C10orf2, TK2, RRM2B, MGME1 |
cellular macromolecule biosynthetic process (GO:0034645) | 1.66 | 7 | SLC25A4, TYMP, POLG, C10orf2, TK2, RRM2B, MGME1 |
aromatic compound biosynthetic process (GO:0019438) | 1.7 | 7 | SUCLG1, TYMP, POLG, SUCLA2, DGUOK, TK2, RRM2B |
organic cyclic compound biosynthetic process (GO:1901362) | 1.66 | 7 | TK2, TYMP, POLG, SUCLA2, DGUOK, SUCLG1, RRM2B |
heterocycle biosynthetic process (GO:0018130) | 1.7 | 7 | SUCLG1, TYMP, POLG, SUCLA2, DGUOK, TK2, RRM2B |
organelle organization (GO:0006996) | 2.02 | 6 | SLC25A4, MPV17, MGME1, C10orf2, OPA1, TYMP |
single-organism biosynthetic process (GO:0044711) | 2.8 | 6 | SUCLG1, TYMP, AGK, DGUOK, TK2, RRM2B |
organonitrogen compound metabolic process (GO:1901564) | 2.32 | 6 | SLC25A4, AGK, TYMP, SUCLA2, DGUOK, TK2 |
organonitrogen compound biosynthetic process (GO:1901566) | 2.85 | 6 | SLC25A4, AGK, TYMP, SUCLA2, DGUOK, TK2 |
cellular component organization (GO:0016043) | 1.24 | 6 | SLC25A4, MPV17, TYMP, C10orf2, OPA1, MGME1 |
nucleic acid metabolic process (GO:0090304) | 1.46 | 6 | MGME1, POLG, C10orf2, TK2, RRM2B, TYMP |
nucleobase-containing compound biosynthetic process (GO:0034654) | 1.72 | 6 | SUCLG1, TYMP, POLG, DGUOK, TK2, RRM2B |
phosphate-containing compound metabolic process (GO:0006796) | 2.16 | 6 | SUCLG1, TYMP, AGK, DGUOK, TK2, RRM2B |
biological regulation (GO:0065007) | 0.39 | 6 | SLC25A4, MPV17, POLG, DGUOK, OPA1, RRM2B |
small molecule metabolic process (GO:0044281) | 2.38 | 6 | SUCLG1, TYMP, SUCLA2, DGUOK, TK2, RRM2B |
phosphorus metabolic process (GO:0006793) | 2.15 | 6 | SUCLG1, TYMP, AGK, DGUOK, TK2, RRM2B |
DNA metabolic process (GO:0006259) | 3.09 | 6 | MGME1, POLG, C10orf2, TK2, RRM2B, TYMP |
cellular component organization or biogenesis (GO:0071840) | 1.22 | 6 | SLC25A4, MPV17, MGME1, C10orf2, OPA1, TYMP |
developmental process (GO:0032502) | 1.36 | 5 | MPV17, TYMP, OPA1, RRM2B, POLG |
cellular response to stimulus (GO:0051716) | 1.97 | 5 | MGME1, RRM2B, OPA1, MPV17, POLG |
mitochondrial genome maintenance (GO:0000002) | 7.16 | 5 | TYMP, MGME1, SLC25A4, OPA1, MPV17 |
response to stimulus (GO:0050896) | 1.22 | 5 | MPV17, MGME1, OPA1, RRM2B, POLG |
regulation of cellular process (GO:0050794) | 0.5 | 5 | DGUOK, RRM2B, SLC25A4, OPA1, MPV17 |
single-organism developmental process (GO:0044767) | 1.49 | 5 | TYMP, RRM2B, OPA1, MPV17, POLG |
response to stress (GO:0006950) | 1.8 | 5 | MPV17, MGME1, OPA1, RRM2B, POLG |
DNA replication (GO:0006260) | 4.51 | 5 | MGME1, RRM2B, TYMP, POLG, C10orf2 |
nucleobase-containing small molecule metabolic process (GO:0055086) | 3.59 | 5 | RRM2B, TYMP, DGUOK, SUCLG1, TK2 |
organophosphate metabolic process (GO:0019637) | 3.04 | 5 | RRM2B, TK2, DGUOK, TYMP, SUCLG1 |
nucleoside phosphate metabolic process (GO:0006753) | 3.71 | 5 | RRM2B, TYMP, DGUOK, SUCLG1, TK2 |
regulation of biological process (GO:0050789) | 0.45 | 5 | SLC25A4, RRM2B, DGUOK, OPA1, MPV17 |
mitochondrion organization (GO:0007005) | 3.69 | 5 | MGME1, OPA1, SLC25A4, TYMP, MPV17 |
carbohydrate derivative metabolic process (GO:1901135) | 3.07 | 4 | RRM2B, DGUOK, TYMP, TK2 |
nucleotide metabolic process (GO:0009117) | 3.73 | 4 | TYMP, DGUOK, RRM2B, TK2 |
nucleoside phosphate biosynthetic process (GO:1901293) | 4.47 | 4 | RRM2B, DGUOK, TK2, SUCLG1 |
cellular response to stress (GO:0033554) | 2.51 | 4 | RRM2B, OPA1, MGME1, MPV17 |
negative regulation of biological process (GO:0048519) | 1.33 | 4 | SLC25A4, RRM2B, DGUOK, OPA1 |
organophosphate biosynthetic process (GO:0090407) | 3.67 | 4 | RRM2B, DGUOK, TK2, SUCLG1 |
negative regulation of cellular process (GO:0048523) | 1.41 | 4 | DGUOK, RRM2B, SLC25A4, OPA1 |
mitochondrial DNA metabolic process (GO:0032042) | 7.09 | 3 | MGME1, RRM2B, POLG |
acyl-CoA metabolic process (GO:0006637) | 5.31 | 3 | SUCLA2, AGK, SUCLG1 |
coenzyme metabolic process (GO:0006732) | 4.14 | 3 | SUCLA2, AGK, SUCLG1 |
phosphorylation (GO:0016310) | 2.63 | 3 | DGUOK, TK2, AGK |
carbohydrate derivative biosynthetic process (GO:1901137) | 3.73 | 3 | RRM2B, TYMP, TK2 |
nucleotide biosynthetic process (GO:0009165) | 4.49 | 3 | RRM2B, DGUOK, TK2 |
regulation of signaling (GO:0023051) | 1.72 | 3 | RRM2B, SLC25A4, OPA1 |
regulation of cell communication (GO:0010646) | 1.73 | 3 | RRM2B, SLC25A4, OPA1 |
cellular protein metabolic process (GO:0044267) | 1.63 | 3 | SLC25A4, FBXL4, DGUOK |
regulation of cell death (GO:0010941) | 2.43 | 3 | RRM2B, SLC25A4, OPA1 |
mitochondrial DNA replication (GO:0006264) | 7.53 | 3 | MGME1, RRM2B, POLG |
regulation of programmed cell death (GO:0043067) | 2.49 | 3 | RRM2B, SLC25A4, OPA1 |
DNA-dependent DNA replication (GO:0006261) | 6.29 | 3 | MGME1, RRM2B, POLG |
nucleoside triphosphate metabolic process (GO:0009141) | 4.61 | 3 | RRM2B, DGUOK, SUCLG1 |
regulation of biological quality (GO:0065008) | 1.68 | 3 | SLC25A4, MPV17, POLG |
negative regulation of programmed cell death (GO:0043069) | 3.02 | 3 | RRM2B, SLC25A4, OPA1 |
thioester metabolic process (GO:0035383) | 5.31 | 3 | SUCLA2, AGK, SUCLG1 |
multicellular organismal process (GO:0032501) | 1.45 | 3 | TYMP, RRM2B, OPA1 |
negative regulation of cell death (GO:0060548) | 2.95 | 3 | RRM2B, SLC25A4, OPA1 |
cofactor metabolic process (GO:0051186) | 3.91 | 3 | SUCLA2, AGK, SUCLG1 |
nucleoside metabolic process (GO:0009116) | 4.12 | 3 | TYMP, DGUOK, TK2 |
response to chemical (GO:0042221) | 1.98 | 3 | RRM2B, MPV17, POLG |
cellular metabolic compound salvage (GO:0043094) | 6.07 | 3 | TYMP, DGUOK, TK2 |
protein metabolic process (GO:0019538) | 1.45 | 3 | SLC25A4, FBXL4, DGUOK |
anatomical structure development (GO:0048856) | 1.58 | 3 | TYMP, RRM2B, MPV17 |
glycosyl compound metabolic process (GO:1901657) | 4.04 | 3 | TYMP, DGUOK, TK2 |
sulfur compound metabolic process (GO:0006790) | 3.87 | 3 | SUCLA2, AGK, SUCLG1 |
negative regulation of apoptotic signaling pathway (GO:2001234) | 4.42 | 2 | RRM2B, OPA1 |
regulation of neuron projection development (GO:0010975) | 3.69 | 2 | DGUOK, OPA1 |
regulation of apoptotic signaling pathway (GO:2001233) | 3.83 | 2 | RRM2B, OPA1 |
negative regulation of response to stimulus (GO:0048585) | 2.52 | 2 | RRM2B, OPA1 |
regulation of response to stimulus (GO:0048583) | 1.54 | 2 | RRM2B, OPA1 |
negative regulation of cellular component organization (GO:0051129) | 3.35 | 2 | DGUOK, OPA1 |
regulation of cellular component organization (GO:0051128) | 2.01 | 2 | DGUOK, OPA1 |
homeostatic process (GO:0042592) | 2.61 | 2 | MPV17, POLG |
negative regulation of signaling (GO:0023057) | 2.65 | 2 | RRM2B, OPA1 |
tricarboxylic acid cycle (GO:0006099) | 6.33 | 2 | SUCLA2, SUCLG1 |
deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 7.43 | 2 | DGUOK, TK2 |
nucleoside biosynthetic process (GO:0009163) | 4.97 | 2 | TYMP, TK2 |
cellular response to chemical stimulus (GO:0070887) | 2.57 | 2 | MPV17, POLG |
dicarboxylic acid metabolic process (GO:0043648) | 5.3 | 2 | SUCLA2, SUCLG1 |
pyrimidine nucleoside biosynthetic process (GO:0046134) | 6.26 | 2 | TYMP, TK2 |
nucleoside monophosphate metabolic process (GO:0009123) | 4.54 | 2 | DGUOK, TK2 |
localization (GO:0051179) | 1.4 | 2 | SLC25A4, OPA1 |
regulation of apoptotic process (GO:0042981) | 2.5 | 2 | RRM2B, OPA1 |
regulation of cell projection organization (GO:0031344) | 3.38 | 2 | DGUOK, OPA1 |
nucleoside monophosphate biosynthetic process (GO:0009124) | 5.26 | 2 | DGUOK, TK2 |
pyrimidine-containing compound metabolic process (GO:0072527) | 5.36 | 2 | TYMP, TK2 |
negative regulation of cell communication (GO:0010648) | 2.66 | 2 | RRM2B, OPA1 |
regulation of neurogenesis (GO:0050767) | 3.21 | 2 | DGUOK, OPA1 |
organic substance catabolic process (GO:1901575) | 2.45 | 2 | TYMP, FBXL4 |
regulation of intracellular signal transduction (GO:1902531) | 2.31 | 2 | RRM2B, OPA1 |
negative regulation of signal transduction (GO:0009968) | 2.75 | 2 | RRM2B, OPA1 |
regulation of signal transduction (GO:0009966) | 1.84 | 2 | RRM2B, OPA1 |
cellular developmental process (GO:0048869) | 1.82 | 2 | TYMP, OPA1 |
deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 6.78 | 2 | RRM2B, DGUOK |
cofactor biosynthetic process (GO:0051188) | 4.62 | 2 | SUCLA2, AGK |
regulation of cell development (GO:0060284) | 3.01 | 2 | DGUOK, OPA1 |
response to organic substance (GO:0010033) | 2.2 | 2 | RRM2B, POLG |
regulation of neuron differentiation (GO:0045664) | 3.39 | 2 | DGUOK, OPA1 |
deoxyribonucleoside metabolic process (GO:0009120) | 7.78 | 2 | DGUOK, TK2 |
negative regulation of apoptotic process (GO:0043066) | 3.04 | 2 | RRM2B, OPA1 |
single-organism localization (GO:1902578) | 2.09 | 2 | SLC25A4, OPA1 |
protein modification process (GO:0036211) | 1.79 | 2 | DGUOK, FBXL4 |
negative regulation of intracellular signal transduction (GO:1902532) | 3.63 | 2 | RRM2B, OPA1 |
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) | 5.21 | 2 | RRM2B, OPA1 |
regulation of intrinsic apoptotic signaling pathway (GO:2001242) | 4.74 | 2 | RRM2B, OPA1 |
pyrimidine-containing compound biosynthetic process (GO:0072528) | 5.99 | 2 | TYMP, TK2 |
DNA repair (GO:0006281) | 3.59 | 2 | MGME1, RRM2B |
regulation of developmental process (GO:0050793) | 2.1 | 2 | DGUOK, OPA1 |
transport (GO:0006810) | 1.51 | 2 | SLC25A4, OPA1 |
carboxylic acid metabolic process (GO:0019752) | 3.12 | 2 | SUCLA2, SUCLG1 |
cellular protein modification process (GO:0006464) | 1.79 | 2 | DGUOK, FBXL4 |
cellular response to DNA damage stimulus (GO:0006974) | 3.17 | 2 | MGME1, RRM2B |
regulation of cell differentiation (GO:0045595) | 2.42 | 2 | DGUOK, OPA1 |
single-organism transport (GO:0044765) | 2.18 | 2 | SLC25A4, OPA1 |
deoxyribonucleotide metabolic process (GO:0009262) | 6.2 | 2 | RRM2B, DGUOK |
amide biosynthetic process (GO:0043604) | 3.6 | 2 | SLC25A4, AGK |
regulation of multicellular organismal process (GO:0051239) | 1.87 | 2 | DGUOK, OPA1 |
oxoacid metabolic process (GO:0043436) | 3.12 | 2 | SUCLA2, SUCLG1 |
establishment of localization (GO:0051234) | 1.48 | 2 | SLC25A4, OPA1 |
catabolic process (GO:0009056) | 2.38 | 2 | TYMP, FBXL4 |
response to oxidative stress (GO:0006979) | 3.9 | 2 | RRM2B, MPV17 |
cellular catabolic process (GO:0044248) | 2.62 | 2 | TYMP, FBXL4 |
system process (GO:0003008) | 2.3 | 2 | RRM2B, OPA1 |
response to oxygen-containing compound (GO:1901700) | 2.57 | 2 | MPV17, POLG |
cellular response to oxygen-containing compound (GO:1901701) | 3.22 | 2 | MPV17, POLG |
pyrimidine nucleoside salvage (GO:0043097) | 7.24 | 2 | TYMP, TK2 |
aging (GO:0007568) | 4.16 | 2 | OPA1, POLG |
organic acid metabolic process (GO:0006082) | 3.01 | 2 | SUCLA2, SUCLG1 |
pyrimidine-containing compound salvage (GO:0008655) | 7.24 | 2 | TYMP, TK2 |
nucleic acid phosphodiester bond hydrolysis (GO:0090305) | 4.12 | 2 | MGME1, POLG |
nucleoside salvage (GO:0043174) | 6.9 | 2 | TYMP, TK2 |
deoxyribonucleoside monophosphate biosynthetic process (GO:0009157) | 7.78 | 2 | DGUOK, TK2 |
macromolecule modification (GO:0043412) | 1.73 | 2 | DGUOK, FBXL4 |
pyrimidine nucleoside metabolic process (GO:0006213) | 5.8 | 2 | TYMP, TK2 |
succinate metabolic process (GO:0006105) | 7.43 | 2 | SUCLA2, SUCLG1 |
succinyl-CoA metabolic process (GO:0006104) | 8.12 | 2 | SUCLA2, SUCLG1 |
regulation of nervous system development (GO:0051960) | 3.1 | 2 | DGUOK, OPA1 |
regulation of multicellular organismal development (GO:2000026) | 2.31 | 2 | DGUOK, OPA1 |
cellular amide metabolic process (GO:0043603) | 3.23 | 2 | SLC25A4, AGK |
DNA biosynthetic process (GO:0071897) | 4.89 | 2 | TK2, POLG |
glycosyl compound biosynthetic process (GO:1901659) | 4.95 | 2 | TYMP, TK2 |