Disease table of NEPHROTIC SYNDROME OMIM ID: PS256300

Gene-disease associations table

GeneAssociated with NEPHROTIC SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
WT1ClinVar, OMIM, HUMSAVARHGNC link11p136194080, PS194070, PS256300, 608978, 156240, 136680
PLCE1ClinVar, OMIM, HUMSAVARHGNC link10q23.331PS256300
NUP107ClinVar, OMIMHGNC link12q151PS256300
ADCK4ClinVar, OMIM, HUMSAVARHGNC link19q13.21PS256300
ARHGDIAClinVar, OMIMHGNC link17q25.31PS256300
NUP93ClinVar, OMIMHGNC link16q131PS256300
NPHS2ClinVar, OMIM, HUMSAVARHGNC link1q25.21PS256300
NPHS1ClinVar, OMIM, HUMSAVARHGNC link19q13.121PS256300
PTPROClinVar, OMIMHGNC link12p12.31PS256300
EMP2ClinVar, OMIM, HUMSAVARHGNC link16p13.131PS256300
OPA1ClinVarHGNC link3q296PS256300, 210000, PS165500, PS603041, 125250, 606657
LAMB2ClinVar, OMIM, HUMSAVARHGNC link3p21.312PS256300, 609049
NUP205ClinVar, OMIMHGNC link7q331PS256300
DGKEClinVar, OMIM, HUMSAVARHGNC link17q222PS235400, PS256300

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
19q132ADCK4, NPHS1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22DGKE, ARHGDIA
19q12ADCK4, NPHS1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
19q2ADCK4, NPHS1
17q2DGKE, ARHGDIA
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122PTPRO, NUP107
172DGKE, ARHGDIA
162NUP93, EMP2
192ADCK4, NPHS1
32OPA1, LAMB2
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
WT1YES51MYC, NR5A1, CTGF, AR, CD97, TBXA2R, MYB, EGFR, HBEGF, DNMT3A, ITGAX, CCNE1, ABCB1, EREG, THBS1, CIAO1, NOV, NDRG2, SMAD3, CD14, SNAI2, NPHS1, CDKN1A, PDGFA, TERT, IRF8, VDR, PODXL, CDH1, STIM1, JUN, CKM, AMH, CYP19A1, VEGFA, VEGFB, ODC1, ETS1, KLK3, JUNB, BCL2, IGF1R, PAX2, IGF2, IL2RB, MYCN, IGF1, SRY, UBE2I, CX3CL1, CAMP1NPHS1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
WT1YES10ZHX3, EP300, IFI16, PAX2, TFCP2, GATA1, RELA, PAX8, NFKB1, GATA20
NPHS2YES2LMX1B, USF10
NPHS1YES1WT11WT1
PTPROYES1E2F10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
WT1NUP107No2UBE2I, SUZ12
WT1NUP93No2UBE2I, SUZ12
WT1NUP205No1UBE2I
NUP107ARHGDIANo4NTRK1, CUL3, SIRT7, CUL7
NUP107NUP93Yes27RCC1, SUZ12, NUP214, NXF1, NUP205, CDC5L, SIRT7, RAE1, NUP153, NUPL1, KPNB1, IFI16, OBSL1, EED, NUP107, TPR, NUP35, SEH1L, NUP188, NUP62, KIFC1, NUP98, CUL7, RANBP2, NTRK1, UBE2I, CUL3
NUP107PTPRONo1VCP
NUP107OPA1No2NTRK1, CUL3
NUP107NUP205Yes26VCP, FOXL1, NUP35, NUP214, NXF1, NUP93, RCC1, SIRT7, NUP153, TPR, KPNB1, IFI16, OBSL1, EED, NUP107, NUPL1, NUP155, SEH1L, FOXQ1, FOXI2, NUP98, CUL3, RANBP2, NTRK1, UBE2I, CUL7
ARHGDIANUP93No7ADRB2, CCDC8, UCHL3, SIRT7, NTRK1, CUL3, CUL7
ARHGDIAPTPRONo1SH3GL3
ARHGDIAOPA1No2NTRK1, CUL3
ARHGDIALAMB2No1CCDC8
ARHGDIANUP205No5NTRK1, CUL3, SIRT7, CUL7, CCDC8
NUP93OPA1No6EGFR, ELAVL1, XRCC3, NTRK1, MYC, CUL3
NUP93LAMB2No2FBXO6, CCDC8
NUP93NUP205Yes30RCC1, NUP35, NXF1, TAT, NUP214, VCAM1, SIRT7, FBXO6, NUPL1, KPNB1, NUP107, ITGA4, OBSL1, NUP153, EED, IFI16, CLN3, TPR, PHLDA3, RNF2, SEH1L, UBE2I, CCDC8, NUP98, PHB2, RANBP2, NTRK1, MYC, CUL3, CUL7
NPHS2NPHS1Yes4SH3KBP1, NPHS1, NPHS2, CD2AP
PTPROOPA1No1APP
PTPRONUP205No1VCP
OPA1NUP205No3NTRK1, MYC, CUL3
LAMB2NUP205No2FBXO6, CCDC8
NUP205DGKENo1TCTN3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NUP93NUP205No1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
WT1PLCE1No-1TP53
WT1NUP107No-1U2AF2
WT1ARHGDIANo-1AKT1
WT1NUP93No-1U2AF2
WT1NPHS2No-1NPHS1
WT1NPHS1Yesactivation, binding0
WT1EMP2No-1VEGFA
WT1NUP205No-1U2AF2
PLCE1ARHGDIANo-1RHOA
NUP107ARHGDIANo-1UBC
NUP107NUP93Yesbinding80SRRM1, CDC40, GEMIN5, NUP214, NXF2B, NUP37, SRSF2, NUP133, NFX1, DHX38, AAAS, GEMIN7, GEMIN2, NXF1, NUP85, UPF3B, NUP205, MAGOH, SRSF7, GCK, RNPS1, SNRPE, NCBP2, SRSF6, SRSF1, NUP88, SRSF9, NUP35, RAE1, CPSF2, CPSF3, TPR, NUP54, NCOA5, U2AF1, RPTN, U2AF2, NUP62CL, NEK9, SNRPG, RANBP2, SAC3D1, NUP153, ALYREF, PHAX, NUP210, GLE1, UBC, GCKR, NXF2, SEH1L, NPM1, SRSF5, SNRPB, SNRPF, NUP188, DDX20, SRSF11, AHCTF1, NUP155, NUP43, NUP62, NEK6, SLBP, MCM3AP, NCBP1, GEMIN6, SNRPD1, NUP98, SNUPN, EIF4E, NUP50, SNRPD3, SRSF3, NUP160, KPNB1, SRSF4, GEMIN4, NUPL2, SNRPD2
NUP107NPHS1No-1UBC
NUP107LAMB2No-1UBC
NUP107NUP205Yesbinding73SRRM1, CDC40, GEMIN5, NUP214, SNRPE, NUP37, SRSF2, NUP133, NFX1, DHX38, NUP88, GEMIN7, GEMIN2, NXF1, NUP85, UPF3B, NUP93, MAGOH, NEK6, GCK, RNPS1, NCBP2, SRSF6, SRSF1, AAAS, SRSF9, NUP35, RAE1, CPSF2, CPSF3, TPR, NUP54, NUP43, U2AF1, NUP62CL, NEK9, SNRPG, RANBP2, SRSF7, NUP153, PHAX, NUP210, GCKR, ALYREF, SEH1L, NPM1, SRSF5, SNRPB, SNRPF, NUP188, DDX20, GLE1, SRSF11, NUP155, KPNB1, NUP62, U2AF2, SLBP, SRSF3, NCBP1, GEMIN6, SNRPD1, NUP98, SNUPN, EIF4E, NUP50, UBC, SNRPD3, NUP160, SRSF4, GEMIN4, NUPL2, SNRPD2
ARHGDIANUP93No-1UBC
ARHGDIANPHS1No-5SRC, UBC, NGFR, SNAI1, PRKCA
ARHGDIALAMB2No-6RAC1, UBC, PAK2, CDC42, SRC, PAK1
ARHGDIANUP205No-1UBC
NUP93NPHS1No-1UBC
NUP93LAMB2No-1UBC
NUP93NUP205Yesbinding73SRRM1, CDC40, GEMIN5, NUP214, NUP107, SNRPE, NUP37, SRSF2, NUP133, NFX1, DHX38, NUP88, GEMIN7, GEMIN2, NXF1, NUP85, UPF3B, MAGOH, SRSF7, GCK, RNPS1, NCBP2, SRSF6, SRSF1, AAAS, SRSF9, NUP35, RAE1, CPSF2, CPSF3, TPR, NUP54, NUP43, U2AF1, NUP62CL, NEK9, SNRPG, RANBP2, NEK6, NUP153, PHAX, NUP210, GCKR, ALYREF, SEH1L, NPM1, SRSF5, SNRPB, SNRPF, NUP188, DDX20, GLE1, SRSF11, NUP155, KPNB1, NUP62, U2AF2, SLBP, SRSF3, NCBP1, GEMIN6, SNRPD1, NUP98, SNUPN, EIF4E, NUP50, UBC, SNRPD3, NUP160, SRSF4, GEMIN4, NUPL2, SNRPD2
NPHS2NPHS1Yesbinding10PLCG1, CD2AP, NCK2, TRPC6, SH3KBP1, NCK1, FYN, WASL, GRB2, KIRREL
NPHS1LAMB2No-2SRC, UBC
NPHS1NUP205No-1UBC
LAMB2NUP205No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
NUP107NUP93No1NUP155
NUP107NUP205No1NUP155
NUP93NUP205Yes4NUP155, NUP62, NUP93, NUP205

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
RNA transporthsa030135.373NUP107, NUP93, NUP205
Phosphatidylinositol signaling systemhsa040706.382DGKE, PLCE1
Metabolic pathwayshsa011002.492DGKE, PLCE1

NET-GE enrichment

Term New enriched termICP valueGenes
Signal transductionNEW2.060.046WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP205, LAMB2, OPA1, NPHS1, DGKE
RNA transport (hsa03013) -5.370.031NUP107, NUP93, NUP205
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.344NUP107, NUP93, NUP205, PLCE1
Nuclear import of Rev proteinR-HSA-1807468.033NUP107, NUP93, NUP205
Transmembrane transport of small moleculesR-HSA-3825513.793NUP107, NUP93, NUP205
Immune SystemR-HSA-1682562.373NUP107, NUP93, NUP205
Influenza InfectionR-HSA-1682545.863NUP107, NUP93, NUP205
Influenza Viral RNA Transcription and ReplicationR-HSA-1682735.993NUP107, NUP93, NUP205
Cytokine Signaling in Immune systemR-HSA-12802153.743NUP107, NUP93, NUP205
Nuclear Pore Complex (NPC) DisassemblyR-HSA-33018547.943NUP107, NUP93, NUP205
Cell CycleR-HSA-16401703.893NUP107, NUP93, NUP205
Post-translational protein modificationR-HSA-5975924.543NUP107, NUP93, NUP205
ISG15 antiviral mechanismR-HSA-11694086.833NUP107, NUP93, NUP205
DiseaseR-HSA-16436853.333NUP107, NUP93, NUP205
Host Interactions of HIV factorsR-HSA-1629095.993NUP107, NUP93, NUP205
Metabolism of carbohydratesR-HSA-713874.933NUP107, NUP93, NUP205
Gene ExpressionR-HSA-741602.723NUP107, NUP93, NUP205
Cellular responses to stressR-HSA-22627524.563NUP107, NUP93, NUP205
HIV InfectionR-HSA-1629065.223NUP107, NUP93, NUP205
Cell Cycle, MitoticR-HSA-692784.163NUP107, NUP93, NUP205
SUMOylationR-HSA-29908466.683NUP107, NUP93, NUP205
Late Phase of HIV Life CycleR-HSA-1625996.023NUP107, NUP93, NUP205
Interferon SignalingR-HSA-9135314.953NUP107, NUP93, NUP205
Regulatory RNA pathwaysR-HSA-2110006.353NUP107, NUP93, NUP205
Viral Messenger RNA SynthesisR-HSA-1683257.623NUP107, NUP93, NUP205
Infectious diseaseR-HSA-56632054.473NUP107, NUP93, NUP205
Metabolism of proteinsR-HSA-3924993.413NUP107, NUP93, NUP205
Vpr-mediated nuclear import of PICsR-HSA-1809108.033NUP107, NUP93, NUP205
M PhaseR-HSA-688864.873NUP107, NUP93, NUP205
Regulation of Glucokinase by Glucokinase Regulatory ProteinR-HSA-1708228.123NUP107, NUP93, NUP205
SLC-mediated transmembrane transportR-HSA-4254074.953NUP107, NUP93, NUP205
Glucose transportR-HSA-701537.623NUP107, NUP93, NUP205
Influenza Life CycleR-HSA-1682555.923NUP107, NUP93, NUP205
Antiviral mechanism by IFN-stimulated genesR-HSA-11694106.833NUP107, NUP93, NUP205
Hexose transportR-HSA-1892007.433NUP107, NUP93, NUP205
Interactions of Vpr with host cellular proteinsR-HSA-1760337.893NUP107, NUP93, NUP205
SUMO E3 ligases SUMOylate target proteinsR-HSA-31082326.773NUP107, NUP93, NUP205
Interactions of Rev with host cellular proteinsR-HSA-1772437.893NUP107, NUP93, NUP205
Rev-mediated nuclear export of HIV RNAR-HSA-1650547.983NUP107, NUP93, NUP205
Cellular response to heat stressR-HSA-33715566.593NUP107, NUP93, NUP205
SUMOylation of DNA damage response and repair proteinsR-HSA-31082146.773NUP107, NUP93, NUP205
Transcriptional regulation by small RNAsR-HSA-55787496.853NUP107, NUP93, NUP205
Regulation of HSF1-mediated heat shock responseR-HSA-33714536.943NUP107, NUP93, NUP205
HIV Life CycleR-HSA-1625875.893NUP107, NUP93, NUP205
Nuclear Envelope BreakdownR-HSA-29807667.343NUP107, NUP93, NUP205
Signal TransductionR-HSA-1625821.783ARHGDIA, NUP107, DGKE
Mitotic ProphaseR-HSA-688756.273NUP107, NUP93, NUP205
Cell-Cell communicationR-HSA-15009315.872NPHS2, NPHS1
Signaling by Rho GTPasesR-HSA-1943154.432ARHGDIA, NUP107
Nephrin interactionsR-HSA-3737538.462NPHS2, NPHS1

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of Glucokinase by Glucokinase Regulatory Protein (R-HSA-170822) -8.120.0NUP107, NUP93, NUP205
Influenza Viral RNA Transcription and Replication (R-HSA-168273) -5.990.022NUP107, NUP93, NUP205
ISG15 antiviral mechanism (R-HSA-1169408) -6.830.004NUP107, NUP93, NUP205
Nuclear Pore Complex (NPC) Disassembly (R-HSA-3301854) -7.940.0NUP107, NUP93, NUP205
Host Interactions of HIV factors (R-HSA-162909) -5.990.022NUP107, NUP93, NUP205
SUMOylation (R-HSA-2990846) -6.680.022NUP107, NUP93, NUP205
Late Phase of HIV Life Cycle (R-HSA-162599) -6.020.021NUP107, NUP93, NUP205
Regulatory RNA pathways (R-HSA-211000) -6.350.011NUP107, NUP93, NUP205
Viral Messenger RNA Synthesis (R-HSA-168325) -7.620.001NUP107, NUP93, NUP205
Nuclear import of Rev protein (R-HSA-180746) -8.030.0NUP107, NUP93, NUP205
Vpr-mediated nuclear import of PICs (R-HSA-180910) -8.030.0NUP107, NUP93, NUP205
Influenza Infection (R-HSA-168254) -5.860.029NUP107, NUP93, NUP205
Glucose transport (R-HSA-70153) -7.620.001NUP107, NUP93, NUP205
Influenza Life Cycle (R-HSA-168255) -5.920.026NUP107, NUP93, NUP205
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410) -6.830.004NUP107, NUP93, NUP205
Hexose transport (R-HSA-189200) -7.430.001NUP107, NUP93, NUP205
Interactions of Vpr with host cellular proteins (R-HSA-176033) -7.890.0NUP107, NUP93, NUP205
SUMO E3 ligases SUMOylate target proteins (R-HSA-3108232) -6.770.018NUP107, NUP93, NUP205
Interactions of Rev with host cellular proteins (R-HSA-177243) -7.890.0NUP107, NUP93, NUP205
Rev-mediated nuclear export of HIV RNA (R-HSA-165054) -7.980.0NUP107, NUP93, NUP205
Cellular response to heat stress (R-HSA-3371556) -6.590.006NUP107, NUP93, NUP205
SUMOylation of DNA damage response and repair proteins (R-HSA-3108214) -6.770.018NUP107, NUP93, NUP205
Transcriptional regulation by small RNAs (R-HSA-5578749) -6.850.013NUP107, NUP93, NUP205
Regulation of HSF1-mediated heat shock response (R-HSA-3371453) -6.940.011NUP107, NUP93, NUP205
HIV Life Cycle (R-HSA-162587) -5.890.027NUP107, NUP93, NUP205
Nuclear Envelope Breakdown (R-HSA-2980766) -7.340.001NUP107, NUP93, NUP205
Nephrin interactions (R-HSA-373753) -8.460.021NPHS2, NPHS1
Mitotic Prophase (R-HSA-68875) -6.270.013NUP107, NUP93, NUP205
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1812WT1, ARHGDIA, NUP205, PTPRO, PLCE1, NUP107, EMP2, LAMB2, OPA1, NPHS2, NPHS1, DGKE
protein binding (GO:0005515) 0.4611WT1, ARHGDIA, NUP205, PTPRO, PLCE1, NUP107, EMP2, LAMB2, OPA1, NPHS2, NPHS1
catalytic activity (GO:0003824) 1.054OPA1, PLCE1, DGKE, PTPRO
structural molecule activity (GO:0005198) 3.14NUP107, NUP93, LAMB2, NUP205
ion binding (GO:0043167) 1.364WT1, ARHGDIA, DGKE, OPA1
cation binding (GO:0043169) 1.43WT1, OPA1, DGKE
structural constituent of nuclear pore (GO:0017056) 7.13NUP107, NUP93, NUP205
hydrolase activity (GO:0016787) 1.93OPA1, PLCE1, PTPRO
organic cyclic compound binding (GO:0097159) 1.053WT1, DGKE, OPA1
enzyme binding (GO:0019899) 2.273ARHGDIA, PLCE1, EMP2
metal ion binding (GO:0046872) 1.413WT1, DGKE, OPA1
heterocyclic compound binding (GO:1901363) 1.063WT1, OPA1, DGKE
purine ribonucleoside triphosphate binding (GO:0035639) 2.222DGKE, OPA1
phosphoric ester hydrolase activity (GO:0042578) 3.822PLCE1, PTPRO
small GTPase binding (GO:0031267) 4.132ARHGDIA, PLCE1
GTPase binding (GO:0051020) 4.052ARHGDIA, PLCE1
macromolecular complex binding (GO:0044877) 2.612LAMB2, EMP2
signal transducer activity (GO:0004871) 2.282PLCE1, PTPRO
molecular function regulator (GO:0098772) 2.512ARHGDIA, PLCE1
purine nucleoside binding (GO:0001883) 2.222DGKE, OPA1
nucleoside binding (GO:0001882) 2.212DGKE, OPA1
nucleotide binding (GO:0000166) 1.962OPA1, DGKE
nucleoside phosphate binding (GO:1901265) 1.962OPA1, DGKE
ribonucleoside binding (GO:0032549) 2.222DGKE, OPA1
protein complex binding (GO:0032403) 3.092LAMB2, EMP2
purine nucleotide binding (GO:0017076) 2.192DGKE, OPA1
integrin binding (GO:0005178) 5.072LAMB2, EMP2
hydrolase activity, acting on ester bonds (GO:0016788) 3.12PLCE1, PTPRO
Ras GTPase binding (GO:0017016) 4.22ARHGDIA, PLCE1
protein kinase binding (GO:0019901) 3.442ARHGDIA, EMP2
kinase binding (GO:0019900) 3.322ARHGDIA, EMP2
cell adhesion molecule binding (GO:0050839) 4.52LAMB2, EMP2
small molecule binding (GO:0036094) 1.892DGKE, OPA1
carbohydrate derivative binding (GO:0097367) 2.032DGKE, OPA1
purine ribonucleotide binding (GO:0032555) 2.22OPA1, DGKE
receptor binding (GO:0005102) 2.432LAMB2, EMP2
purine ribonucleoside binding (GO:0032550) 2.222DGKE, OPA1
ribonucleotide binding (GO:0032553) 2.192DGKE, OPA1

NET-GE enrichment

Term New enriched termICP valueGenes
structural constituent of nuclear pore (GO:0017056) -7.10.0NUP107, NUP93, NUP205
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2613WT1, ARHGDIA, NUP93, PLCE1, PTPRO, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1, DGKE
single-organism cellular process (GO:0044763) 0.6513WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1, DGKE
single-organism process (GO:0044699) 0.4813WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1, DGKE
cellular component organization (GO:0016043) 1.2411WT1, NUP93, PLCE1, PTPRO, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1
biological regulation (GO:0065007) 0.3911WT1, ARHGDIA, NUP93, PLCE1, PTPRO, NUP107, NUP205, EMP2, OPA1, NPHS1, DGKE
regulation of biological process (GO:0050789) 0.4511WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS1, DGKE
cellular component organization or biogenesis (GO:0071840) 1.2211WT1, NUP93, PLCE1, PTPRO, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1
regulation of cellular process (GO:0050794) 0.511WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS1, DGKE
organic substance metabolic process (GO:0071704) 0.638WT1, NUP93, PTPRO, PLCE1, NUP107, NUP205, NPHS1, DGKE
regulation of response to stimulus (GO:0048583) 1.548ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, OPA1
cellular metabolic process (GO:0044237) 0.698WT1, NUP93, PTPRO, PLCE1, NUP107, NUP205, NPHS1, DGKE
metabolic process (GO:0008152) 0.588WT1, NUP93, PTPRO, PLCE1, NUP107, NUP205, NPHS1, DGKE
primary metabolic process (GO:0044238) 0.698WT1, NUP93, PTPRO, PLCE1, NUP107, NUP205, NPHS1, DGKE
developmental process (GO:0032502) 1.367WT1, PTPRO, PLCE1, LAMB2, OPA1, NPHS2, NPHS1
multicellular organismal process (GO:0032501) 1.457WT1, PTPRO, EMP2, LAMB2, OPA1, NPHS2, NPHS1
single-organism developmental process (GO:0044767) 1.497WT1, PTPRO, PLCE1, LAMB2, OPA1, NPHS2, NPHS1
regulation of multicellular organismal process (GO:0051239) 1.877WT1, ARHGDIA, PLCE1, PTPRO, EMP2, OPA1, NPHS1
negative regulation of biological process (GO:0048519) 1.337WT1, ARHGDIA, NUP93, PTPRO, NUP107, NUP205, OPA1
regulation of localization (GO:0032879) 1.947ARHGDIA, NUP93, PTPRO, NUP107, NUP205, EMP2, NPHS1
organelle organization (GO:0006996) 2.026NUP93, PLCE1, NUP107, NUP205, OPA1, NPHS2
organic substance biosynthetic process (GO:1901576) 1.346WT1, NUP93, PLCE1, NUP107, NUP205, DGKE
macromolecule metabolic process (GO:0043170) 0.836WT1, NUP93, PTPRO, NUP107, NUP205, NPHS1
regulation of metabolic process (GO:0019222) 1.026WT1, NUP93, PLCE1, NUP107, NUP205, EMP2
cellular macromolecule metabolic process (GO:0044260) 0.936WT1, NUP93, PTPRO, NUP107, NUP205, NPHS1
regulation of macromolecule metabolic process (GO:0060255) 1.086WT1, NUP93, PLCE1, NUP107, NUP205, EMP2
cellular developmental process (GO:0048869) 1.826WT1, PTPRO, LAMB2, OPA1, NPHS2, NPHS1
anatomical structure development (GO:0048856) 1.586WT1, PTPRO, PLCE1, LAMB2, NPHS2, NPHS1
regulation of cellular component organization (GO:0051128) 2.016WT1, ARHGDIA, PTPRO, PLCE1, OPA1, NPHS1
cellular biosynthetic process (GO:0044249) 1.376WT1, NUP93, PLCE1, NUP107, NUP205, DGKE
biosynthetic process (GO:0009058) 1.326WT1, NUP93, PLCE1, NUP107, NUP205, DGKE
positive regulation of biological process (GO:0048518) 1.26WT1, ARHGDIA, PLCE1, EMP2, OPA1, NPHS1
system process (GO:0003008) 2.36PTPRO, EMP2, LAMB2, OPA1, NPHS2, NPHS1
localization (GO:0051179) 1.46NUP93, NUP107, NUP205, EMP2, OPA1, NPHS1
positive regulation of cellular process (GO:0048522) 1.36WT1, ARHGDIA, PLCE1, EMP2, OPA1, NPHS1
protein localization (GO:0008104) 2.365NUP107, NPHS1, NUP93, EMP2, NUP205
regulation of anatomical structure morphogenesis (GO:0022603) 2.795WT1, EMP2, ARHGDIA, OPA1, PTPRO
movement of cell or subcellular component (GO:0006928) 2.615ARHGDIA, EMP2, LAMB2, OPA1, PTPRO
membrane organization (GO:0061024) 3.045NUP107, NUP93, EMP2, OPA1, NUP205
cellular component assembly (GO:0022607) 2.145NUP107, NUP93, EMP2, PTPRO, NUP205
regulation of signaling (GO:0023051) 1.725ARHGDIA, EMP2, OPA1, PLCE1, PTPRO
regulation of cell communication (GO:0010646) 1.735ARHGDIA, EMP2, OPA1, PLCE1, PTPRO
cellular protein metabolic process (GO:0044267) 1.635NUP107, NPHS1, NUP93, PTPRO, NUP205
regulation of signal transduction (GO:0009966) 1.845ARHGDIA, EMP2, OPA1, PLCE1, PTPRO
macromolecule localization (GO:0033036) 2.345NUP93, NPHS1, NUP107, EMP2, NUP205
regulation of developmental process (GO:0050793) 2.15WT1, ARHGDIA, OPA1, EMP2, PTPRO
transport (GO:0006810) 1.515NUP107, NUP93, OPA1, EMP2, NUP205
cellular protein modification process (GO:0006464) 1.795NUP107, NPHS1, NUP93, PTPRO, NUP205
macromolecule modification (GO:0043412) 1.735NUP107, NPHS1, NUP93, PTPRO, NUP205
protein modification process (GO:0036211) 1.795NUP107, NPHS1, NUP93, PTPRO, NUP205
single-organism membrane organization (GO:0044802) 3.195NUP107, NUP93, EMP2, OPA1, NUP205
establishment of localization in cell (GO:0051649) 2.475NUP93, OPA1, NUP107, EMP2, NUP205
establishment of localization (GO:0051234) 1.485NUP107, NUP93, OPA1, EMP2, NUP205
single-organism localization (GO:1902578) 2.095NUP93, OPA1, NUP107, EMP2, NUP205
cellular localization (GO:0051641) 2.325NUP107, NUP93, OPA1, EMP2, NUP205
intracellular transport (GO:0046907) 2.675NUP107, OPA1, NUP93, EMP2, NUP205
protein metabolic process (GO:0019538) 1.455NUP107, NPHS1, NUP93, PTPRO, NUP205
response to stimulus (GO:0050896) 1.225WT1, ARHGDIA, NPHS1, OPA1, EMP2
regulation of multicellular organismal development (GO:2000026) 2.315WT1, EMP2, ARHGDIA, OPA1, PTPRO
single-organism cellular localization (GO:1902580) 3.165NUP93, OPA1, NUP107, EMP2, NUP205
negative regulation of metabolic process (GO:0009892) 1.934WT1, NUP93, NUP205, NUP107
regulation of primary metabolic process (GO:0080090) 1.084WT1, NUP107, EMP2, PLCE1
regulation of transport (GO:0051049) 2.244NUP107, NPHS1, NUP93, NUP205
cell development (GO:0048468) 3.284WT1, NPHS1, NPHS2, LAMB2
nucleic acid metabolic process (GO:0090304) 1.464WT1, NUP93, NUP205, NUP107
negative regulation of gene expression (GO:0010629) 2.484WT1, NUP93, NUP205, NUP107
nitrogen compound metabolic process (GO:0006807) 1.134WT1, NUP93, NUP205, NUP107
signal transduction (GO:0007165) 1.284ARHGDIA, NPHS1, DGKE, PLCE1
regulation of cell differentiation (GO:0045595) 2.424ARHGDIA, OPA1, EMP2, PTPRO
intracellular signal transduction (GO:0035556) 2.394ARHGDIA, NPHS1, DGKE, PLCE1
organic cyclic compound biosynthetic process (GO:1901362) 1.664WT1, NUP93, NUP205, NUP107
organic cyclic compound metabolic process (GO:1901360) 1.264WT1, NUP93, NUP205, NUP107
RNA biosynthetic process (GO:0032774) 1.844WT1, NUP93, NUP205, NUP107
nucleobase-containing compound metabolic process (GO:0006139) 1.354WT1, NUP93, NUP205, NUP107
cellular response to stimulus (GO:0051716) 1.974WT1, ARHGDIA, NPHS1, OPA1
negative regulation of macromolecule metabolic process (GO:0010605) 2.014WT1, NUP93, NUP205, NUP107
regulation of system process (GO:0044057) 3.534PLCE1, NPHS1, EMP2, PTPRO
regulation of gene expression (GO:0010468) 1.374WT1, NUP93, NUP205, NUP107
heterocycle biosynthetic process (GO:0018130) 1.74WT1, NUP93, NUP205, NUP107
regulation of cellular metabolic process (GO:0031323) 1.074WT1, NUP107, PLCE1, EMP2
cellular aromatic compound metabolic process (GO:0006725) 1.34WT1, NUP93, NUP205, NUP107
single-organism transport (GO:0044765) 2.184NUP107, NUP93, OPA1, NUP205
macromolecule biosynthetic process (GO:0009059) 1.614WT1, NUP93, NUP205, NUP107
aromatic compound biosynthetic process (GO:0019438) 1.74WT1, NUP93, NUP205, NUP107
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724WT1, NUP93, NUP205, NUP107
heterocycle metabolic process (GO:0046483) 1.314WT1, NUP93, NUP205, NUP107
RNA metabolic process (GO:0016070) 1.594WT1, NUP93, NUP205, NUP107
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594WT1, NUP93, NUP205, NUP107
regulation of response to stress (GO:0080134) 2.534NUP107, NUP93, NUP205, OPA1
regulation of cellular response to stress (GO:0080135) 3.44NUP107, NUP93, OPA1, NUP205
cellular nitrogen compound metabolic process (GO:0034641) 1.224WT1, NUP93, NUP205, NUP107
phosphate-containing compound metabolic process (GO:0006796) 2.164DGKE, NPHS1, PLCE1, PTPRO
phosphorus metabolic process (GO:0006793) 2.154DGKE, NPHS1, PLCE1, PTPRO
single-organism intracellular transport (GO:1902582) 3.594NUP107, NUP93, NUP205, OPA1
negative regulation of cellular process (GO:0048523) 1.414WT1, ARHGDIA, OPA1, PTPRO
nuclear transport (GO:0051169) 4.23NUP107, NUP93, NUP205
nuclear export (GO:0051168) 4.743NUP107, NUP93, NUP205
regulation of cell projection organization (GO:0031344) 3.383ARHGDIA, OPA1, PTPRO
single-organism metabolic process (GO:0044710) 1.633NPHS1, PLCE1, DGKE
positive regulation of macromolecule metabolic process (GO:0010604) 1.813WT1, PLCE1, EMP2
cellular macromolecule localization (GO:0070727) 3.13NUP93, NUP107, EMP2
protein modification by small protein conjugation or removal (GO:0070647) 2.953NUP107, NUP93, NUP205
peptidyl-amino acid modification (GO:0018193) 2.983NUP107, NUP93, NUP205
intracellular transport of virus (GO:0075733) 5.573NUP107, NUP93, NUP205
interspecies interaction between organisms (GO:0044419) 3.083NUP107, NUP93, NUP205
protein modification by small protein conjugation (GO:0032446) 3.13NUP107, NUP93, NUP205
gene silencing (GO:0016458) 4.63NUP107, NUP93, NUP205
animal organ development (GO:0048513) 2.533WT1, NPHS1, PLCE1
positive regulation of molecular function (GO:0044093) 2.233ARHGDIA, EMP2, PLCE1
epithelial cell development (GO:0002064) 4.923NPHS1, NPHS2, LAMB2
glomerular basement membrane development (GO:0032836) 7.433WT1, NPHS1, LAMB2
negative regulation of cell death (GO:0060548) 2.953WT1, ARHGDIA, OPA1
glomerulus development (GO:0032835) 7.333WT1, PLCE1, PTPRO
nuclear pore complex assembly (GO:0051292) 7.333NUP107, NUP93, NUP205
establishment of protein localization (GO:0045184) 2.533NUP107, NUP93, NUP205
regulation of neuron projection development (GO:0010975) 3.693ARHGDIA, OPA1, PTPRO
mitotic nuclear envelope disassembly (GO:0007077) 5.943NUP107, NUP93, NUP205
multi-organism process (GO:0051704) 2.653NUP107, NUP93, NUP205
peptidyl-lysine modification (GO:0018205) 3.983NUP107, NUP93, NUP205
extracellular matrix organization (GO:0030198) 4.013WT1, NPHS1, LAMB2
positive regulation of metabolic process (GO:0009893) 1.743WT1, PLCE1, EMP2
viral transcription (GO:0019083) 4.983NUP107, NUP93, NUP205
mRNA transport (GO:0051028) 4.743NUP107, NUP93, NUP205
regulation of apoptotic process (GO:0042981) 2.53WT1, ARHGDIA, OPA1
cell morphogenesis (GO:0000902) 4.353WT1, LAMB2, PTPRO
macromolecular complex assembly (GO:0065003) 2.553NUP107, NUP93, NUP205
regulation of molecular function (GO:0065009) 1.783ARHGDIA, PLCE1, EMP2
regulation of biological quality (GO:0065008) 1.683ARHGDIA, NPHS1, PLCE1
positive regulation of cellular component organization (GO:0051130) 2.683ARHGDIA, NPHS1, OPA1
cellular protein localization (GO:0034613) 3.113NUP93, NUP107, EMP2
regulation of neurogenesis (GO:0050767) 3.213ARHGDIA, OPA1, PTPRO
regulation of catalytic activity (GO:0050790) 1.973ARHGDIA, PLCE1, EMP2
tRNA transport (GO:0051031) 6.23NUP107, NUP93, NUP205
establishment of RNA localization (GO:0051236) 4.583NUP107, NUP93, NUP205
regulation of intracellular signal transduction (GO:1902531) 2.313ARHGDIA, PLCE1, OPA1
RNA transport (GO:0050658) 4.593NUP107, NUP93, NUP205
organic substance transport (GO:0071702) 2.153NUP107, NUP93, NUP205
nucleic acid transport (GO:0050657) 4.593NUP107, NUP93, NUP205
regulation of nervous system development (GO:0051960) 3.13ARHGDIA, OPA1, PTPRO
transport of virus (GO:0046794) 5.523NUP107, NUP93, NUP205
nucleobase-containing compound transport (GO:0015931) 4.423NUP107, NUP93, NUP205
regulation of organelle organization (GO:0033043) 2.723ARHGDIA, NPHS1, OPA1
regulation of cell adhesion (GO:0030155) 3.273ARHGDIA, EMP2, PTPRO
negative regulation of cellular component organization (GO:0051129) 3.353ARHGDIA, OPA1, PTPRO
glomerular epithelial cell development (GO:0072310) 7.433NPHS1, NPHS2, LAMB2
anatomical structure morphogenesis (GO:0009653) 2.533WT1, LAMB2, PTPRO
positive regulation of catalytic activity (GO:0043085) 2.43ARHGDIA, EMP2, PLCE1
glomerular visceral epithelial cell development (GO:0072015) 7.533NPHS1, NPHS2, LAMB2
pore complex assembly (GO:0046931) 6.963NUP107, NUP93, NUP205
regulation of neuron differentiation (GO:0045664) 3.393ARHGDIA, OPA1, PTPRO
positive regulation of multicellular organismal process (GO:0051240) 2.493WT1, ARHGDIA, OPA1
negative regulation of multicellular organismal process (GO:0051241) 2.843WT1, ARHGDIA, PTPRO
regulation of protein metabolic process (GO:0051246) 1.933WT1, PLCE1, EMP2
nuclear envelope disassembly (GO:0051081) 5.883NUP107, NUP93, NUP205
regulation of cell development (GO:0060284) 3.013ARHGDIA, OPA1, PTPRO
macromolecular complex subunit organization (GO:0043933) 2.143NUP107, NUP93, NUP205
biological adhesion (GO:0022610) 2.813NPHS1, LAMB2, EMP2
regulation of cellular component movement (GO:0051270) 3.083ARHGDIA, EMP2, PTPRO
protein sumoylation (GO:0016925) 4.983NUP107, NUP93, NUP205
negative regulation of developmental process (GO:0051093) 3.173WT1, ARHGDIA, PTPRO
membrane disassembly (GO:0030397) 5.883NUP107, NUP93, NUP205
regulation of cellular protein metabolic process (GO:0032268) 1.993WT1, PLCE1, EMP2
positive regulation of developmental process (GO:0051094) 2.773WT1, ARHGDIA, OPA1
regulation of cellular response to heat (GO:1900034) 5.413NUP107, NUP93, NUP205
cell projection organization (GO:0030030) 3.143LAMB2, EMP2, PTPRO
positive regulation of cellular metabolic process (GO:0031325) 1.813WT1, EMP2, PLCE1
mitotic cell cycle process (GO:1903047) 3.123NUP107, NUP93, NUP205
regulation of glucose transport (GO:0010827) 5.123NUP107, NUP93, NUP205
cell cycle process (GO:0022402) 2.753NUP107, NUP93, NUP205
protein transport (GO:0015031) 2.623NUP107, NUP93, NUP205
cellular macromolecular complex assembly (GO:0034622) 3.183NUP107, NUP93, NUP205
regulation of cell death (GO:0010941) 2.433WT1, ARHGDIA, OPA1
protein complex subunit organization (GO:0071822) 2.63NUP107, NUP93, NUP205
cellular component morphogenesis (GO:0032989) 3.53WT1, LAMB2, PTPRO
nitrogen compound transport (GO:0071705) 3.543NUP107, NUP93, NUP205
tRNA export from nucleus (GO:0006409) 6.263NUP107, NUP93, NUP205
regulation of programmed cell death (GO:0043067) 2.493WT1, ARHGDIA, OPA1
negative regulation of apoptotic process (GO:0043066) 3.043WT1, ARHGDIA, OPA1
extracellular structure organization (GO:0043062) 4.03WT1, NPHS1, LAMB2
negative regulation of programmed cell death (GO:0043069) 3.023WT1, ARHGDIA, OPA1
RNA export from nucleus (GO:0006405) 5.013NUP107, NUP93, NUP205
mRNA export from nucleus (GO:0006406) 5.113NUP107, NUP93, NUP205
protein complex assembly (GO:0006461) 2.783NUP107, NUP93, NUP205
nucleocytoplasmic transport (GO:0006913) 4.233NUP107, NUP93, NUP205
multi-organism transport (GO:0044766) 5.513NUP107, NUP93, NUP205
multi-organism cellular process (GO:0044764) 3.143NUP107, NUP93, NUP205
cellular component disassembly (GO:0022411) 3.523NUP107, NUP93, NUP205
gene silencing by RNA (GO:0031047) 5.073NUP107, NUP93, NUP205
cell adhesion (GO:0007155) 2.823NPHS1, LAMB2, EMP2
cellular protein complex assembly (GO:0043623) 3.93NUP107, NUP93, NUP205
multi-organism localization (GO:1902579) 5.513NUP107, NUP93, NUP205
nucleus organization (GO:0006997) 5.493NUP107, NUP93, NUP205
regulation of locomotion (GO:0040012) 3.123ARHGDIA, EMP2, PTPRO
nuclear envelope organization (GO:0006998) 5.453NUP107, NUP93, NUP205
nuclear pore organization (GO:0006999) 7.023NUP107, NUP93, NUP205
single-organism organelle organization (GO:1902589) 2.683NPHS2, NUP93, OPA1
viral process (GO:0016032) 3.153NUP107, NUP93, NUP205
multi-organism intracellular transport (GO:1902583) 5.573NUP107, NUP93, NUP205
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.153NUP107, NUP93, NUP205
(GO:1902581) 5.573NUP107, NUP93, NUP205
regulation of phosphate metabolic process (GO:0019220) 2.352EMP2, PLCE1
negative regulation of response to stimulus (GO:0048585) 2.522OPA1, PTPRO
positive regulation of response to stimulus (GO:0048584) 2.182PLCE1, EMP2
activation of protein kinase activity (GO:0032147) 4.082PLCE1, EMP2
negative regulation of cell adhesion (GO:0007162) 4.332ARHGDIA, PTPRO
renal system process (GO:0003014) 5.172EMP2, PTPRO
cell surface receptor signaling pathway (GO:0007166) 2.092ARHGDIA, PLCE1
negative regulation of cell projection organization (GO:0031345) 4.722ARHGDIA, PTPRO
mitochondrion organization (GO:0007005) 3.692NUP93, OPA1
positive regulation of cell projection organization (GO:0031346) 3.992ARHGDIA, OPA1
muscle organ development (GO:0007517) 4.982WT1, NPHS1
single-organism biosynthetic process (GO:0044711) 2.82DGKE, PLCE1
negative regulation of signal transduction (GO:0009968) 2.752OPA1, PTPRO
positive regulation of signal transduction (GO:0009967) 2.52PLCE1, EMP2
regulation of glomerular filtration (GO:0003093) 7.332EMP2, PTPRO
regulation of cytoskeleton organization (GO:0051493) 3.722ARHGDIA, NPHS1
negative regulation of neuron differentiation (GO:0045665) 4.452ARHGDIA, PTPRO
positive regulation of neuron differentiation (GO:0045666) 3.982ARHGDIA, OPA1
positive regulation of cell development (GO:0010720) 3.572ARHGDIA, OPA1
epithelial cell differentiation (GO:0030855) 3.982WT1, PTPRO
regulation of cell proliferation (GO:0042127) 2.412WT1, EMP2
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082ARHGDIA, PLCE1
regulation of protein kinase activity (GO:0045859) 3.152EMP2, PLCE1
visual perception (GO:0007601) 4.412LAMB2, OPA1
sensory perception (GO:0007600) 2.932LAMB2, OPA1
negative regulation of neuron projection development (GO:0010977) 4.882ARHGDIA, PTPRO
positive regulation of neuron projection development (GO:0010976) 4.262ARHGDIA, OPA1
regulation of RNA biosynthetic process (GO:2001141) 1.552WT1, NUP107
neuron projection guidance (GO:0097485) 4.432LAMB2, PTPRO
response to organic substance (GO:0010033) 2.22WT1, ARHGDIA
regulation of phosphorylation (GO:0042325) 2.52EMP2, PLCE1
positive regulation of phosphorylation (GO:0042327) 2.92PLCE1, EMP2
single organism reproductive process (GO:0044702) 2.732WT1, EMP2
single-multicellular organism process (GO:0044707) 1.782WT1, NPHS1
cell motility (GO:0048870) 3.022EMP2, PTPRO
positive regulation of organelle organization (GO:0010638) 3.382NPHS1, OPA1
immune system process (GO:0002376) 2.292EMP2, PTPRO
cellular response to stress (GO:0033554) 2.512NPHS1, OPA1
organophosphate metabolic process (GO:0019637) 3.042DGKE, PLCE1
regulation of cell morphogenesis (GO:0022604) 3.42ARHGDIA, PTPRO
glomerular epithelial cell differentiation (GO:0072311) 7.782WT1, PTPRO
positive regulation of kinase activity (GO:0033674) 3.542PLCE1, EMP2
protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205) 6.262DGKE, PLCE1
cell differentiation involved in kidney development (GO:0061005) 6.642WT1, PTPRO
regulation of vasculature development (GO:1901342) 4.262WT1, EMP2
regulation of cell migration (GO:0030334) 3.232ARHGDIA, EMP2
actin filament-based process (GO:0030029) 3.942NPHS2, EMP2
cell morphogenesis involved in differentiation (GO:0000904) 4.672WT1, LAMB2
positive regulation of transferase activity (GO:0051347) 3.312EMP2, PLCE1
positive regulation of GTPase activity (GO:0043547) 3.282ARHGDIA, PLCE1
positive regulation of hydrolase activity (GO:0051345) 2.912ARHGDIA, PLCE1
intracellular protein transport (GO:0006886) 3.22NUP93, NUP107
regulation of kinase activity (GO:0043549) 3.072PLCE1, EMP2
metanephric glomerular visceral epithelial cell development (GO:0072249) 9.042NPHS2, LAMB2
regulation of cell-substrate adhesion (GO:0010810) 4.562EMP2, PTPRO
renal filtration cell differentiation (GO:0061318) 7.782WT1, PTPRO
epithelial cell differentiation involved in kidney development (GO:0035850) 7.432WT1, PTPRO
cell migration (GO:0016477) 3.122EMP2, PTPRO
G-protein coupled receptor signaling pathway (GO:0007186) 2.642DGKE, PLCE1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012WT1, NPHS1
lipid metabolic process (GO:0006629) 2.682DGKE, PLCE1
regulation of biosynthetic process (GO:0009889) 1.372WT1, NUP107
tissue development (GO:0009888) 3.272WT1, NPHS1
sensory perception of light stimulus (GO:0050953) 4.42LAMB2, OPA1
negative regulation of cell morphogenesis involved in differentiation (GO:0010771) 4.962ARHGDIA, PTPRO
response to stress (GO:0006950) 1.82NPHS1, OPA1
glomerular visceral epithelial cell differentiation (GO:0072112) 7.782WT1, PTPRO
regulation of actin cytoskeleton organization (GO:0032956) 4.092ARHGDIA, NPHS1
regulation of hydrolase activity (GO:0051336) 2.532ARHGDIA, PLCE1
excretion (GO:0007588) 6.042NPHS2, NPHS1
positive regulation of protein modification process (GO:0031401) 2.72EMP2, PLCE1
regulation of transferase activity (GO:0051338) 2.882EMP2, PLCE1
positive regulation of nervous system development (GO:0051962) 3.642ARHGDIA, OPA1
negative regulation of nervous system development (GO:0051961) 4.152ARHGDIA, PTPRO
regulation of macromolecule biosynthetic process (GO:0010556) 1.432WT1, NUP107
regulation of cell motility (GO:2000145) 3.162ARHGDIA, EMP2
regulation of response to external stimulus (GO:0032101) 3.062NUP93, PTPRO
phosphorylation (GO:0016310) 2.632NPHS1, DGKE
protein import (GO:0017038) 4.852NUP93, NUP107
cell differentiation (GO:0030154) 2.142WT1, PTPRO
regulation of Ras protein signal transduction (GO:0046578) 4.492ARHGDIA, PLCE1
regulation of cellular biosynthetic process (GO:0031326) 1.382WT1, NUP107
positive regulation of signaling (GO:0023056) 2.412EMP2, PLCE1
negative regulation of signaling (GO:0023057) 2.652OPA1, PTPRO
metanephric glomerular epithelial cell development (GO:0072313) 9.042NPHS2, LAMB2
negative regulation of cell communication (GO:0010648) 2.662OPA1, PTPRO
cellular response to chemical stimulus (GO:0070887) 2.572WT1, ARHGDIA
muscle structure development (GO:0061061) 4.962WT1, NPHS1
axon guidance (GO:0007411) 4.442LAMB2, PTPRO
positive regulation of cell communication (GO:0010647) 2.412EMP2, PLCE1
regulation of GTPase activity (GO:0043087) 3.212ARHGDIA, PLCE1
response to organic cyclic compound (GO:0014070) 3.072WT1, ARHGDIA
positive regulation of phosphorus metabolic process (GO:0010562) 2.782PLCE1, EMP2
positive regulation of protein metabolic process (GO:0051247) 2.432PLCE1, EMP2
negative regulation of neurogenesis (GO:0050768) 4.222ARHGDIA, PTPRO
positive regulation of neurogenesis (GO:0050769) 3.772ARHGDIA, OPA1
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912ARHGDIA, PTPRO
positive regulation of cellular protein metabolic process (GO:0032270) 2.492PLCE1, EMP2
regulation of protein modification process (GO:0031399) 2.322EMP2, PLCE1
phospholipid metabolic process (GO:0006644) 3.882DGKE, PLCE1
cell proliferation (GO:0008283) 3.232PLCE1, EMP2
establishment of protein localization to organelle (GO:0072594) 3.922NUP93, NUP107
negative regulation of cell development (GO:0010721) 4.022ARHGDIA, PTPRO
negative regulation of locomotion (GO:0040013) 4.222ARHGDIA, PTPRO
regulation of nucleic acid-templated transcription (GO:1903506) 1.552WT1, NUP107
positive regulation of cell differentiation (GO:0045597) 3.012ARHGDIA, OPA1
negative regulation of cell differentiation (GO:0045596) 3.332ARHGDIA, PTPRO
regulation of cell growth (GO:0001558) 3.752WT1, PLCE1
cellular lipid metabolic process (GO:0044255) 2.922DGKE, PLCE1
negative regulation of axonogenesis (GO:0050771) 5.522ARHGDIA, PTPRO
regulation of axonogenesis (GO:0050770) 4.592ARHGDIA, PTPRO
cellular response to organic cyclic compound (GO:0071407) 3.932WT1, ARHGDIA
regulation of RNA metabolic process (GO:0051252) 1.522WT1, NUP107
protein localization to organelle (GO:0033365) 3.572NUP93, NUP107
positive regulation of protein kinase activity (GO:0045860) 3.612PLCE1, EMP2
protein localization to nucleus (GO:0034504) 4.92NUP93, NUP107
cell projection assembly (GO:0030031) 4.192EMP2, PTPRO
cell death (GO:0008219) 3.052OPA1, EMP2
regulation of transcription, DNA-templated (GO:0006355) 1.562WT1, NUP107
regulation of growth (GO:0040008) 3.262WT1, PLCE1
single-organism nuclear import (GO:1902593) 5.242NUP93, NUP107
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462WT1, NUP107
renal system process involved in regulation of blood volume (GO:0001977) 6.962EMP2, PTPRO
regulation of renal system process (GO:0098801) 6.122EMP2, PTPRO
cellular response to organic substance (GO:0071310) 2.782WT1, ARHGDIA
neurological system process (GO:0050877) 2.642LAMB2, OPA1
regulation of actin filament-based process (GO:0032970) 3.972ARHGDIA, NPHS1
positive regulation of phosphate metabolic process (GO:0045937) 2.782EMP2, PLCE1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432WT1, NUP107
protein import into nucleus (GO:0006606) 5.242NUP93, NUP107
regulation of phosphorus metabolic process (GO:0051174) 2.352EMP2, PLCE1
reproductive process (GO:0022414) 2.552WT1, EMP2
renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) 6.682EMP2, PTPRO
nuclear import (GO:0051170) 5.062NUP93, NUP107
regulation of nitrogen compound metabolic process (GO:0051171) 1.362WT1, NUP107
response to chemical (GO:0042221) 1.982WT1, ARHGDIA
Ras protein signal transduction (GO:0007265) 4.762ARHGDIA, PLCE1
small GTPase mediated signal transduction (GO:0007264) 3.852ARHGDIA, PLCE1
lipid biosynthetic process (GO:0008610) 3.492DGKE, PLCE1
locomotion (GO:0040011) 2.912EMP2, PTPRO
heart development (GO:0007507) 4.242WT1, PLCE1
negative regulation of cellular component movement (GO:0051271) 4.222ARHGDIA, PTPRO
cytoskeleton organization (GO:0007010) 3.222NPHS2, PLCE1
regulation of protein phosphorylation (GO:0001932) 2.572PLCE1, EMP2
positive regulation of protein phosphorylation (GO:0001934) 2.952PLCE1, EMP2

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of glucose transport (GO:0010827) -5.120.026NUP107, NPHS1, NUP93, NUP205
metanephric glomerular epithelial cell development (GO:0072313) -9.040.0NPHS2, LAMB2
glomerular epithelial cell differentiation (GO:0072311) -7.780.008WT1, PTPRO
glomerular epithelial cell development (GO:0072310) -7.430.0NPHS1, NPHS2, LAMB2
glomerular visceral epithelial cell development (GO:0072015) -7.530.0NPHS1, NPHS2, LAMB2
glomerular visceral epithelial cell differentiation (GO:0072112) -7.780.008WT1, PTPRO
pore complex assembly (GO:0046931) -6.960.0NUP107, NUP93, NUP205
hexose transport (GO:0008645) NEW5.760.013NUP107, NUP93, NUP205
metanephric glomerular visceral epithelial cell development (GO:0072249) -9.040.0NPHS2, LAMB2
nuclear envelope disassembly (GO:0051081) -5.880.009NUP107, NUP93, NUP205
carbohydrate transport (GO:0008643) NEW5.160.041NUP107, NUP93, NUP205
glucose transport (GO:0015758) NEW5.80.012NUP107, NUP93, NUP205
renal filtration cell differentiation (GO:0061318) -7.780.008WT1, PTPRO
epithelial cell differentiation involved in kidney development (GO:0035850) -7.430.028WT1, PTPRO
epithelial cell development (GO:0002064) -4.920.043NPHS1, NPHS2, LAMB2
glomerular basement membrane development (GO:0032836) -7.430.0WT1, NPHS1, LAMB2
glomerulus development (GO:0032835) -7.330.002WT1, PLCE1, PTPRO
nuclear pore complex assembly (GO:0051292) -7.330.0NUP107, NUP93, NUP205
mitotic nuclear envelope disassembly (GO:0007077) -5.940.006NUP107, NUP93, NUP205
nucleus organization (GO:0006997) -5.490.003NUP107, NUP93, NUP205
membrane disassembly (GO:0030397) -5.880.009NUP107, NUP93, NUP205
nuclear envelope organization (GO:0006998) -5.450.005NUP107, NUP93, NUP205
nuclear pore organization (GO:0006999) -7.020.0NUP107, NUP93, NUP205
monosaccharide transport (GO:0015749) NEW5.760.014NUP107, NUP93, NUP205
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane-bounded organelle (GO:0043227) 0.4712WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1
cell part (GO:0044464) 0.1112WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS2, NPHS1, DGKE
organelle (GO:0043226) 0.412WT1, ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, LAMB2, OPA1, NPHS2, NPHS1
membrane (GO:0016020) 0.6811ARHGDIA, NUP93, PTPRO, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS2, NPHS1, DGKE
intracellular part (GO:0044424) 0.2810WT1, ARHGDIA, NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS2, DGKE
intracellular organelle (GO:0043229) 0.519WT1, ARHGDIA, NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS2
intracellular membrane-bounded organelle (GO:0043231) 0.69WT1, ARHGDIA, NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1, NPHS2
intracellular organelle part (GO:0044446) 0.817WT1, NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1
membrane part (GO:0044425) 0.957ARHGDIA, PTPRO, EMP2, OPA1, NPHS2, NPHS1, DGKE
organelle part (GO:0044422) 0.797WT1, NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1
cytoplasm (GO:0005737) 1.017WT1, ARHGDIA, NUP205, PLCE1, EMP2, OPA1, DGKE
vesicle (GO:0031982) 1.646ARHGDIA, PTPRO, EMP2, LAMB2, NPHS2, NPHS1
integral component of membrane (GO:0016021) 1.146PTPRO, EMP2, OPA1, NPHS2, NPHS1, DGKE
cytoplasmic part (GO:0044444) 0.826ARHGDIA, PLCE1, NUP107, EMP2, OPA1, NPHS2
plasma membrane (GO:0005886) 1.396PTPRO, PLCE1, EMP2, NPHS2, NPHS1, DGKE
nucleus (GO:0005634) 1.076WT1, ARHGDIA, NUP93, NUP107, NUP205, EMP2
intrinsic component of membrane (GO:0031224) 1.136PTPRO, EMP2, OPA1, NPHS2, NPHS1, DGKE
organelle membrane (GO:0031090) 1.976NUP93, PLCE1, NUP107, NUP205, EMP2, OPA1
protein complex (GO:0043234) 1.515NUP107, NUP93, LAMB2, NPHS2, NUP205
extracellular organelle (GO:0043230) 1.895ARHGDIA, NPHS1, NPHS2, LAMB2, PTPRO
extracellular exosome (GO:0070062) 1.895ARHGDIA, NPHS1, NPHS2, LAMB2, PTPRO
membrane-bounded vesicle (GO:0031988) 1.715ARHGDIA, NPHS1, NPHS2, LAMB2, PTPRO
nuclear part (GO:0044428) 1.555WT1, NUP107, NUP93, OPA1, NUP205
macromolecular complex (GO:0032991) 1.355NUP107, NUP93, LAMB2, NPHS2, NUP205
extracellular vesicle (GO:1903561) 1.895ARHGDIA, NPHS1, NPHS2, LAMB2, PTPRO
plasma membrane part (GO:0044459) 1.955ARHGDIA, NPHS2, NPHS1, EMP2, PTPRO
extracellular region part (GO:0044421) 1.575ARHGDIA, NPHS1, NPHS2, LAMB2, PTPRO
nucleoplasm (GO:0005654) 1.894WT1, NUP205, NUP107, OPA1
cytosol (GO:0005829) 1.684ARHGDIA, NUP107, EMP2, PLCE1
nuclear periphery (GO:0034399) 6.763NUP107, NUP93, NUP205
intracellular non-membrane-bounded organelle (GO:0043232) 1.763WT1, ARHGDIA, NUP107
nuclear pore (GO:0005643) 5.463NUP107, NUP93, NUP205
bounding membrane of organelle (GO:0098588) 2.393OPA1, PLCE1, EMP2
nuclear envelope (GO:0005635) 4.723NUP107, NUP93, NUP205
nuclear membrane (GO:0031965) 4.23NUP107, NUP93, NUP205
organelle envelope (GO:0031967) 4.633NUP107, NUP93, NUP205
envelope (GO:0031975) 4.623NUP107, NUP93, NUP205
non-membrane-bounded organelle (GO:0043228) 1.763WT1, ARHGDIA, NUP107
integral component of plasma membrane (GO:0005887) 2.573NPHS2, NPHS1, PTPRO
cell projection (GO:0042995) 2.473NPHS1, OPA1, PTPRO
intrinsic component of plasma membrane (GO:0031226) 2.533NPHS2, NPHS1, PTPRO
plasma membrane region (GO:0098590) 2.972EMP2, PTPRO
cell projection part (GO:0044463) 2.972OPA1, PTPRO
cell-cell junction (GO:0005911) 3.852NPHS2, NPHS1
Golgi apparatus (GO:0005794) 2.72EMP2, PLCE1
apical plasma membrane (GO:0016324) 4.132EMP2, PTPRO
membrane region (GO:0098589) 3.952NPHS2, EMP2
intracellular (GO:0005622) 2.372NPHS1, DGKE
Golgi membrane (GO:0000139) 3.282EMP2, PLCE1
neuron part (GO:0097458) 2.642OPA1, PTPRO
Golgi apparatus part (GO:0044431) 3.02EMP2, PLCE1
filtration diaphragm (GO:0036056) 7.722NPHS2, NPHS1
neuron projection (GO:0043005) 3.122OPA1, PTPRO
membrane raft (GO:0045121) 4.182NPHS2, EMP2
membrane microdomain (GO:0098857) 4.172NPHS2, EMP2
cell junction (GO:0030054) 2.752NPHS2, NPHS1
slit diaphragm (GO:0036057) 7.722NPHS2, NPHS1

NET-GE enrichment

Term New enriched termICP valueGenes
nuclear periphery (GO:0034399) -6.760.0NUP107, NUP93, NUP205
pore complex (GO:0046930) NEW6.970.014NUP107, NUP93, NUP205
nuclear pore (GO:0005643) -5.460.003NUP107, NUP93, NUP205
nuclear envelope (GO:0005635) -4.720.01NUP107, NUP93, NUP205
organelle envelope (GO:0031967) -4.630.013NUP107, NUP93, NUP205
envelope (GO:0031975) -4.620.013NUP107, NUP93, NUP205
filtration diaphragm (GO:0036056) -7.720.004NPHS2, NPHS1
slit diaphragm (GO:0036057) -7.720.004NPHS2, NPHS1