Disease table of HYPOPLASTIC LEFT HEART SYNDROME OMIM ID: PS241550

Gene-disease associations table

GeneAssociated with HYPOPLASTIC LEFT HEART SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GJA1ClinVar, OMIM, HUMSAVARHGNC link6q22.318257850, 186100, 164200, 133200, 104100, PS606215, 218400, PS241550
FOXP1ClinVarHGNC link3p133PS606215, PS241550, 613670
NKX2-5ClinVar, OMIMHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
FOXP1YES2KLK3, RAG10
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GJA1YES2SP1, JUN0
FOXP1YES1ESR10
NKX2-5YES1GATA40
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GJA1NKX2-5No-3MYOCD, TBX2, BMP7
FOXP1NKX2-5No-1YY1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183FOXP1, NKX2-5, GJA1
protein binding (GO:0005515) 0.463FOXP1, NKX2-5, GJA1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372FOXP1, NKX2-5
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362FOXP1, NKX2-5
core promoter proximal region DNA binding (GO:0001159) 3.822FOXP1, NKX2-5
macromolecular complex binding (GO:0044877) 2.612FOXP1, NKX2-5
nucleic acid binding transcription factor activity (GO:0001071) 2.652FOXP1, NKX2-5
nucleic acid binding (GO:0003676) 1.442FOXP1, NKX2-5
DNA binding (GO:0003677) 1.922FOXP1, NKX2-5
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882FOXP1, NKX2-5
heterocyclic compound binding (GO:1901363) 1.062FOXP1, NKX2-5
sequence-specific DNA binding (GO:0043565) 2.792FOXP1, NKX2-5
sequence-specific double-stranded DNA binding (GO:1990837) 3.22FOXP1, NKX2-5
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832FOXP1, NKX2-5
double-stranded DNA binding (GO:0003690) 3.092FOXP1, NKX2-5
identical protein binding (GO:0042802) 2.632FOXP1, NKX2-5
protein homodimerization activity (GO:0042803) 3.162FOXP1, NKX2-5
regulatory region nucleic acid binding (GO:0001067) 3.032FOXP1, NKX2-5
receptor binding (GO:0005102) 2.432FOXP1, GJA1
transcription regulatory region DNA binding (GO:0044212) 3.032FOXP1, NKX2-5
protein heterodimerization activity (GO:0046982) 3.642FOXP1, NKX2-5
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652FOXP1, NKX2-5
organic cyclic compound binding (GO:0097159) 1.052FOXP1, NKX2-5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232FOXP1, NKX2-5
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242FOXP1, NKX2-5
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292FOXP1, NKX2-5
regulatory region DNA binding (GO:0000975) 3.032FOXP1, NKX2-5
protein dimerization activity (GO:0046983) 2.722FOXP1, NKX2-5
chromatin binding (GO:0003682) 3.642FOXP1, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) -5.230.004FOXP1, NKX2-5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of developmental growth (GO:0048638) 4.043FOXP1, NKX2-5, GJA1
negative regulation of metabolic process (GO:0009892) 1.933FOXP1, NKX2-5, GJA1
positive regulation of metabolic process (GO:0009893) 1.743FOXP1, NKX2-5, GJA1
negative regulation of biosynthetic process (GO:0009890) 2.473FOXP1, NKX2-5, GJA1
negative regulation of cellular biosynthetic process (GO:0031327) 2.493FOXP1, NKX2-5, GJA1
regulation of transport (GO:0051049) 2.243FOXP1, NKX2-5, GJA1
negative regulation of response to stimulus (GO:0048585) 2.523FOXP1, NKX2-5, GJA1
cell differentiation (GO:0030154) 2.143FOXP1, NKX2-5, GJA1
regulation of response to stimulus (GO:0048583) 1.543FOXP1, NKX2-5, GJA1
regulation of muscle organ development (GO:0048634) 5.073FOXP1, NKX2-5, GJA1
regulation of cell proliferation (GO:0042127) 2.413FOXP1, NKX2-5, GJA1
negative regulation of gene expression (GO:0010629) 2.483FOXP1, NKX2-5, GJA1
positive regulation of gene expression (GO:0010628) 2.353FOXP1, NKX2-5, GJA1
regulation of organ growth (GO:0046620) 5.413FOXP1, NKX2-5, GJA1
regulation of cell communication (GO:0010646) 1.733FOXP1, NKX2-5, GJA1
multicellular organism development (GO:0007275) 2.543FOXP1, NKX2-5, GJA1
single-organism process (GO:0044699) 0.483FOXP1, NKX2-5, GJA1
regulation of primary metabolic process (GO:0080090) 1.083FOXP1, NKX2-5, GJA1
regulation of localization (GO:0032879) 1.943FOXP1, NKX2-5, GJA1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013FOXP1, NKX2-5, GJA1
regulation of metabolic process (GO:0019222) 1.023FOXP1, NKX2-5, GJA1
regulation of signal transduction (GO:0009966) 1.843FOXP1, NKX2-5, GJA1
cellular developmental process (GO:0048869) 1.823FOXP1, NKX2-5, GJA1
positive regulation of multicellular organismal process (GO:0051240) 2.493FOXP1, NKX2-5, GJA1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463FOXP1, NKX2-5, GJA1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63FOXP1, NKX2-5, GJA1
cellular component organization (GO:0016043) 1.243FOXP1, NKX2-5, GJA1
regulation of biological process (GO:0050789) 0.453FOXP1, NKX2-5, GJA1
regulation of signaling (GO:0023051) 1.723FOXP1, NKX2-5, GJA1
regulation of developmental process (GO:0050793) 2.13FOXP1, NKX2-5, GJA1
animal organ development (GO:0048513) 2.533FOXP1, NKX2-5, GJA1
biological regulation (GO:0065007) 0.393FOXP1, NKX2-5, GJA1
cellular component organization or biogenesis (GO:0071840) 1.223FOXP1, NKX2-5, GJA1
regulation of cellular biosynthetic process (GO:0031326) 1.383FOXP1, NKX2-5, GJA1
positive regulation of biological process (GO:0048518) 1.23FOXP1, NKX2-5, GJA1
negative regulation of biological process (GO:0048519) 1.333FOXP1, NKX2-5, GJA1
negative regulation of cellular metabolic process (GO:0031324) 2.013FOXP1, NKX2-5, GJA1
regulation of gene expression (GO:0010468) 1.373FOXP1, NKX2-5, GJA1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473FOXP1, NKX2-5, GJA1
regulation of muscle tissue development (GO:1901861) 5.073FOXP1, NKX2-5, GJA1
regulation of striated muscle tissue development (GO:0016202) 5.093FOXP1, NKX2-5, GJA1
regulation of heart growth (GO:0060420) 5.973FOXP1, NKX2-5, GJA1
multicellular organismal process (GO:0032501) 1.453FOXP1, NKX2-5, GJA1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553FOXP1, NKX2-5, GJA1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433FOXP1, NKX2-5, GJA1
regulation of cellular metabolic process (GO:0031323) 1.073FOXP1, NKX2-5, GJA1
regulation of cardiac muscle tissue development (GO:0055024) 5.863FOXP1, NKX2-5, GJA1
cellular process (GO:0009987) 0.263FOXP1, NKX2-5, GJA1
regulation of biosynthetic process (GO:0009889) 1.373FOXP1, NKX2-5, GJA1
tissue development (GO:0009888) 3.273FOXP1, NKX2-5, GJA1
regulation of cellular process (GO:0050794) 0.53FOXP1, NKX2-5, GJA1
single-organism developmental process (GO:0044767) 1.493FOXP1, NKX2-5, GJA1
regulation of cell differentiation (GO:0045595) 2.423FOXP1, NKX2-5, GJA1
single-organism cellular process (GO:0044763) 0.653FOXP1, NKX2-5, GJA1
regulation of nitrogen compound metabolic process (GO:0051171) 1.363FOXP1, NKX2-5, GJA1
regulation of multicellular organismal process (GO:0051239) 1.873FOXP1, NKX2-5, GJA1
regulation of cardiac muscle tissue growth (GO:0055021) 6.123FOXP1, NKX2-5, GJA1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813FOXP1, NKX2-5, GJA1
regulation of cardiac muscle cell proliferation (GO:0060043) 6.333FOXP1, NKX2-5, GJA1
heart development (GO:0007507) 4.243FOXP1, NKX2-5, GJA1
negative regulation of developmental process (GO:0051093) 3.173FOXP1, NKX2-5, GJA1
single-multicellular organism process (GO:0044707) 1.783FOXP1, NKX2-5, GJA1
positive regulation of developmental process (GO:0051094) 2.773FOXP1, NKX2-5, GJA1
regulation of macromolecule metabolic process (GO:0060255) 1.083FOXP1, NKX2-5, GJA1
anatomical structure development (GO:0048856) 1.583FOXP1, NKX2-5, GJA1
positive regulation of cell differentiation (GO:0045597) 3.013FOXP1, NKX2-5, GJA1
regulation of growth (GO:0040008) 3.263FOXP1, NKX2-5, GJA1
developmental process (GO:0032502) 1.363FOXP1, NKX2-5, GJA1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433FOXP1, NKX2-5, GJA1
regulation of multicellular organismal development (GO:2000026) 2.313FOXP1, NKX2-5, GJA1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533FOXP1, NKX2-5, GJA1
negative regulation of cellular process (GO:0048523) 1.413FOXP1, NKX2-5, GJA1
positive regulation of cellular process (GO:0048522) 1.33FOXP1, NKX2-5, GJA1
primary metabolic process (GO:0044238) 0.692FOXP1, NKX2-5
regulation of secretion (GO:0051046) 3.22FOXP1, GJA1
cell development (GO:0048468) 3.282FOXP1, NKX2-5
muscle system process (GO:0003012) 4.182NKX2-5, GJA1
circulatory system process (GO:0003013) 4.382NKX2-5, GJA1
signal transduction (GO:0007165) 1.282NKX2-5, GJA1
organic cyclic compound biosynthetic process (GO:1901362) 1.662FOXP1, NKX2-5
organic cyclic compound metabolic process (GO:1901360) 1.262FOXP1, NKX2-5
negative regulation of signal transduction (GO:0009968) 2.752FOXP1, NKX2-5
adult heart development (GO:0007512) 7.162NKX2-5, GJA1
heterocycle metabolic process (GO:0046483) 1.312FOXP1, NKX2-5
muscle contraction (GO:0006936) 4.372NKX2-5, GJA1
positive regulation of transport (GO:0051050) 2.92NKX2-5, GJA1
(GO:1905209) 6.732FOXP1, NKX2-5
negative regulation of cell death (GO:0060548) 2.952FOXP1, NKX2-5
regulation of RNA biosynthetic process (GO:2001141) 1.552FOXP1, NKX2-5
positive regulation of muscle organ development (GO:0048636) 5.692FOXP1, GJA1
response to organic substance (GO:0010033) 2.22FOXP1, GJA1
system process (GO:0003008) 2.32NKX2-5, GJA1
response to external stimulus (GO:0009605) 2.552FOXP1, GJA1
negative regulation of signaling (GO:0023057) 2.652FOXP1, NKX2-5
cardiovascular system development (GO:0072358) 7.242FOXP1, NKX2-5
aromatic compound biosynthetic process (GO:0019438) 1.72FOXP1, NKX2-5
muscle cell differentiation (GO:0042692) 5.092FOXP1, NKX2-5
negative regulation of cell communication (GO:0010648) 2.662FOXP1, NKX2-5
cellular component assembly (GO:0022607) 2.142NKX2-5, GJA1
positive regulation of striated muscle tissue development (GO:0045844) 5.692FOXP1, GJA1
positive regulation of biosynthetic process (GO:0009891) 2.292FOXP1, NKX2-5
positive regulation of muscle tissue development (GO:1901863) 5.672FOXP1, GJA1
movement of cell or subcellular component (GO:0006928) 2.612FOXP1, GJA1
nitrogen compound metabolic process (GO:0006807) 1.132FOXP1, NKX2-5
regulation of protein transport (GO:0051223) 3.122FOXP1, GJA1
regulation of apoptotic process (GO:0042981) 2.52FOXP1, NKX2-5
nucleic acid-templated transcription (GO:0097659) 1.912FOXP1, NKX2-5
organic substance biosynthetic process (GO:1901576) 1.342FOXP1, NKX2-5
regulation of protein secretion (GO:0050708) 3.772FOXP1, GJA1
cellular macromolecule metabolic process (GO:0044260) 0.932FOXP1, NKX2-5
regulation of defense response (GO:0031347) 3.112FOXP1, GJA1
heterocycle biosynthetic process (GO:0018130) 1.72FOXP1, NKX2-5
regulation of establishment of protein localization (GO:0070201) 3.022FOXP1, GJA1
regulation of heart contraction (GO:0008016) 4.352NKX2-5, GJA1
transport (GO:0006810) 1.512FOXP1, GJA1
programmed cell death (GO:0012501) 3.12NKX2-5, GJA1
positive regulation of blood circulation (GO:1903524) 5.162NKX2-5, GJA1
regulation of blood circulation (GO:1903522) 4.052NKX2-5, GJA1
metabolic process (GO:0008152) 0.582FOXP1, NKX2-5
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722FOXP1, NKX2-5
establishment of localization (GO:0051234) 1.482FOXP1, GJA1
RNA metabolic process (GO:0016070) 1.592FOXP1, NKX2-5
negative regulation of RNA biosynthetic process (GO:1902679) 2.72FOXP1, NKX2-5
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592FOXP1, NKX2-5
regulation of response to stress (GO:0080134) 2.532FOXP1, GJA1
biosynthetic process (GO:0009058) 1.322FOXP1, NKX2-5
regulation of transcription, DNA-templated (GO:0006355) 1.562FOXP1, NKX2-5
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FOXP1, NKX2-5
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242FOXP1, NKX2-5
transcription, DNA-templated (GO:0006351) 1.912FOXP1, NKX2-5
RNA biosynthetic process (GO:0032774) 1.842FOXP1, NKX2-5
regulation of response to external stimulus (GO:0032101) 3.062FOXP1, GJA1
regulation of cellular component organization (GO:0051128) 2.012NKX2-5, GJA1
embryo development (GO:0009790) 4.22FOXP1, GJA1
cellular nitrogen compound metabolic process (GO:0034641) 1.222FOXP1, NKX2-5
embryo development ending in birth or egg hatching (GO:0009792) 4.352FOXP1, GJA1
regulation of secretion by cell (GO:1903530) 3.282FOXP1, GJA1
cellular macromolecule biosynthetic process (GO:0034645) 1.662FOXP1, NKX2-5
anatomical structure morphogenesis (GO:0009653) 2.532NKX2-5, GJA1
regulation of protein localization (GO:0032880) 2.882FOXP1, GJA1
nucleobase-containing compound metabolic process (GO:0006139) 1.352FOXP1, NKX2-5
in utero embryonic development (GO:0001701) 4.42FOXP1, GJA1
regulation of system process (GO:0044057) 3.532NKX2-5, GJA1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122FOXP1, NKX2-5
negative regulation of multicellular organismal process (GO:0051241) 2.842FOXP1, GJA1
heart looping (GO:0001947) 5.652NKX2-5, GJA1
epithelial tube morphogenesis (GO:0060562) 5.122NKX2-5, GJA1
chordate embryonic development (GO:0043009) 4.382FOXP1, GJA1
positive regulation of cell proliferation (GO:0008284) 3.012FOXP1, NKX2-5
organelle organization (GO:0006996) 2.022FOXP1, NKX2-5
tube morphogenesis (GO:0035239) 4.352NKX2-5, GJA1
cardiac muscle cell differentiation (GO:0055007) 6.292FOXP1, NKX2-5
epithelium development (GO:0060429) 4.572NKX2-5, GJA1
cellular aromatic compound metabolic process (GO:0006725) 1.32FOXP1, NKX2-5
regulation of nucleic acid-templated transcription (GO:1903506) 1.552FOXP1, NKX2-5
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712FOXP1, NKX2-5
regulation of striated muscle cell differentiation (GO:0051153) 5.262FOXP1, NKX2-5
negative regulation of transcription, DNA-templated (GO:0045892) 2.752FOXP1, NKX2-5
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FOXP1, NKX2-5
regulation of epithelial cell proliferation (GO:0050678) 4.062FOXP1, GJA1
negative regulation of RNA metabolic process (GO:0051253) 2.662FOXP1, NKX2-5
regulation of RNA metabolic process (GO:0051252) 1.522FOXP1, NKX2-5
positive regulation of RNA metabolic process (GO:0051254) 2.512FOXP1, NKX2-5
macromolecule metabolic process (GO:0043170) 0.832FOXP1, NKX2-5
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FOXP1, NKX2-5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812FOXP1, NKX2-5
system development (GO:0048731) 2.922FOXP1, NKX2-5
response to stimulus (GO:0050896) 1.222FOXP1, GJA1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FOXP1, NKX2-5
actomyosin structure organization (GO:0031032) 5.42FOXP1, NKX2-5
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FOXP1, NKX2-5
positive regulation of cellular metabolic process (GO:0031325) 1.812FOXP1, NKX2-5
actin cytoskeleton organization (GO:0030036) 4.12FOXP1, NKX2-5
nucleic acid metabolic process (GO:0090304) 1.462FOXP1, NKX2-5
striated muscle tissue development (GO:0014706) 5.232FOXP1, NKX2-5
regulation of muscle cell differentiation (GO:0051147) 4.682FOXP1, NKX2-5
striated muscle cell differentiation (GO:0051146) 5.692FOXP1, NKX2-5
cell death (GO:0008219) 3.052NKX2-5, GJA1
regulation of cell death (GO:0010941) 2.432FOXP1, NKX2-5
regulation of ion transport (GO:0043269) 3.42NKX2-5, GJA1
morphogenesis of an epithelium (GO:0002009) 4.082NKX2-5, GJA1
(GO:1905207) 6.42FOXP1, NKX2-5
organic substance metabolic process (GO:0071704) 0.632FOXP1, NKX2-5
regulation of programmed cell death (GO:0043067) 2.492FOXP1, NKX2-5
negative regulation of apoptotic process (GO:0043066) 3.042FOXP1, NKX2-5
tissue morphogenesis (GO:0048729) 3.872NKX2-5, GJA1
organic substance transport (GO:0071702) 2.152FOXP1, GJA1
negative regulation of programmed cell death (GO:0043069) 3.022FOXP1, NKX2-5
embryonic morphogenesis (GO:0048598) 3.722NKX2-5, GJA1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FOXP1, NKX2-5
actin filament-based process (GO:0030029) 3.942FOXP1, NKX2-5
apoptotic process (GO:0006915) 3.142NKX2-5, GJA1
cardiocyte differentiation (GO:0035051) 6.022FOXP1, NKX2-5
embryonic heart tube development (GO:0035050) 6.732NKX2-5, GJA1
regulation of metal ion transport (GO:0010959) 3.942NKX2-5, GJA1
single-organism transport (GO:0044765) 2.182FOXP1, GJA1
macromolecule biosynthetic process (GO:0009059) 1.612FOXP1, NKX2-5
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FOXP1, NKX2-5
response to chemical (GO:0042221) 1.982FOXP1, GJA1
tube development (GO:0035295) 4.412NKX2-5, GJA1
localization (GO:0051179) 1.42FOXP1, GJA1
single-organism localization (GO:1902578) 2.092FOXP1, GJA1
response to oxygen-containing compound (GO:1901700) 2.572FOXP1, GJA1
embryonic heart tube morphogenesis (GO:0003143) 5.572NKX2-5, GJA1
cytoskeleton organization (GO:0007010) 3.222FOXP1, NKX2-5
negative regulation of cell differentiation (GO:0045596) 3.332FOXP1, NKX2-5
cellular metabolic process (GO:0044237) 0.692FOXP1, NKX2-5
regulation of cellular component biogenesis (GO:0044087) 3.082NKX2-5, GJA1
single-organism organelle organization (GO:1902589) 2.682FOXP1, NKX2-5
muscle tissue development (GO:0060537) 5.12FOXP1, NKX2-5
sarcomere organization (GO:0045214) 6.42FOXP1, NKX2-5
cellular biosynthetic process (GO:0044249) 1.372FOXP1, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of developmental growth (GO:0048638) -4.040.027FOXP1, NKX2-5, GJA1
actomyosin structure organization (GO:0031032) -5.40.016FOXP1, NKX2-5
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.0FOXP1, NKX2-5, GJA1
regulation of muscle organ development (GO:0048634) -5.070.011FOXP1, NKX2-5, GJA1
striated muscle tissue development (GO:0014706) -5.230.032FOXP1, NKX2-5, GJA1
regulation of muscle cell differentiation (GO:0051147) -4.680.008FOXP1, NKX2-5, GJA1
striated muscle cell differentiation (GO:0051146) -5.690.013FOXP1, NKX2-5
tube morphogenesis (GO:0035239) -4.350.047NKX2-5, GJA1
adult heart development (GO:0007512) -7.160.001NKX2-5, GJA1
regulation of growth (GO:0040008) -3.260.014FOXP1, NKX2-5, GJA1
heart looping (GO:0001947) -5.650.014NKX2-5, GJA1
epithelial tube morphogenesis (GO:0060562) -5.120.038NKX2-5, GJA1
regulation of muscle tissue development (GO:1901861) -5.070.0FOXP1, NKX2-5, GJA1
regulation of striated muscle tissue development (GO:0016202) -5.090.01FOXP1, NKX2-5, GJA1
regulation of heart growth (GO:0060420) -5.970.0FOXP1, NKX2-5, GJA1
regulation of cardiac muscle cell differentiation (GO:2000725) NEW6.780.024FOXP1, GJA1
cardiac muscle cell differentiation (GO:0055007) -6.290.004FOXP1, NKX2-5
regulation of organ growth (GO:0046620) -5.410.003FOXP1, NKX2-5, GJA1
regulation of cardiac muscle tissue development (GO:0055024) -5.860.001FOXP1, NKX2-5, GJA1
cardiocyte differentiation (GO:0035051) -6.020.007FOXP1, NKX2-5
tissue development (GO:0009888) -3.270.021FOXP1, NKX2-5, GJA1
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.0FOXP1, NKX2-5, GJA1
regulation of striated muscle cell differentiation (GO:0051153) -5.260.033FOXP1, NKX2-5, GJA1
sarcomere organization (GO:0045214) -6.40.044FOXP1, NKX2-5
negative regulation of striated muscle cell differentiation (GO:0051154) NEW6.510.018NKX2-5, GJA1
negative regulation of developmental process (GO:0051093) -3.170.024FOXP1, NKX2-5, GJA1
embryonic heart tube morphogenesis (GO:0003143) -5.570.018NKX2-5, GJA1
positive regulation of developmental process (GO:0051094) -2.770.047FOXP1, NKX2-5, GJA1
cardiac muscle tissue development (GO:0048738) NEW6.330.043NKX2-5, GJA1
muscle tissue development (GO:0060537) -5.10.006FOXP1, NKX2-5, GJA1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63FOXP1, NKX2-5, GJA1
cell part (GO:0044464) 0.113FOXP1, NKX2-5, GJA1
intracellular organelle part (GO:0044446) 0.813FOXP1, NKX2-5, GJA1
intracellular organelle (GO:0043229) 0.513FOXP1, NKX2-5, GJA1
intracellular part (GO:0044424) 0.283FOXP1, NKX2-5, GJA1
membrane-bounded organelle (GO:0043227) 0.473FOXP1, NKX2-5, GJA1
organelle (GO:0043226) 0.43FOXP1, NKX2-5, GJA1
organelle part (GO:0044422) 0.793FOXP1, NKX2-5, GJA1
cytoplasm (GO:0005737) 1.012NKX2-5, GJA1
protein complex (GO:0043234) 1.512NKX2-5, GJA1
nucleus (GO:0005634) 1.072FOXP1, NKX2-5
nuclear part (GO:0044428) 1.552FOXP1, NKX2-5
macromolecular complex (GO:0032991) 1.352NKX2-5, GJA1

NET-GE enrichment

Term New enriched termICP valueGenes
cell-cell contact zone (GO:0044291) NEW5.690.015NKX2-5, GJA1