Disease table of CONOTRUNCAL HEART MALFORMATIONS OMIM ID: 217095

Gene-disease associations table

GeneAssociated with CONOTRUNCAL HEART MALFORMATIONS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ZFPM2HUMSAVARHGNC link8q22.34187500, 610187, PS400044, 217095
GDF1OMIM, HUMSAVARHGNC link19p13.114187500, 208530, PS608808, 217095
TBX1OMIM, HUMSAVARHGNC link22q11.214187500, 188400, 192430, 217095
GATA6OMIM, HUMSAVARHGNC link18q11.25600001, PS108800, 217095, PS606215, 187500
NKX2-6OMIM, HUMSAVARHGNC link8p21.21217095
NKX2-5OMIMHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
82ZFPM2, NKX2-6
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
GATA6YES9DKK1, PLAU, CYP17A1, APOA1, CAV1, CYP11A1, VWF, SULT2A1, DAB20
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GATA6YES4HEY2, HEY1, NANOG, POU5F10
NKX2-5YES1GATA40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ZFPM2NKX2-5No2HDAC1, GATA4
GATA6NKX2-5No1EWSR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ZFPM2GATA6Yesbinding3GATA3, ZFPM1, GATA4
ZFPM2NKX2-5No-1GATA4
GATA6NKX2-5No-5BMP2, CALR, MYOCD, SMAD2, GATA4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882GATA6, ZFPM2
HemostasisR-HSA-1095823.982GATA6, ZFPM2

NET-GE enrichment

Term New enriched termICP valueGenes
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) -5.880.013GATA6, ZFPM2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
protein binding (GO:0005515) 0.465ZFPM2, GDF1, GATA6, TBX1, NKX2-5
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.655NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
organic cyclic compound binding (GO:0097159) 1.055NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nucleic acid binding transcription factor activity (GO:0001071) 2.655NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
nucleic acid binding (GO:0003676) 1.445NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
DNA binding (GO:0003677) 1.925NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
heterocyclic compound binding (GO:1901363) 1.065NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
sequence-specific DNA binding (GO:0043565) 2.794GATA6, TBX1, NKX2-6, NKX2-5
transcription factor binding (GO:0008134) 3.463GATA6, ZFPM2, NKX2-5
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.293GATA6, ZFPM2, NKX2-5
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362GATA6, NKX2-5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982GATA6, NKX2-5
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076) 4.842ZFPM2, NKX2-5
macromolecular complex binding (GO:0044877) 2.612GATA6, NKX2-5
zinc ion binding (GO:0008270) 2.662GATA6, ZFPM2
cation binding (GO:0043169) 1.42ZFPM2, GATA6
transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) 5.282ZFPM2, NKX2-5
sequence-specific double-stranded DNA binding (GO:1990837) 3.22GATA6, NKX2-5
transition metal ion binding (GO:0046914) 2.482GATA6, ZFPM2
transcription cofactor activity (GO:0003712) 3.442ZFPM2, NKX2-5
ion binding (GO:0043167) 1.362GATA6, ZFPM2
transcription factor activity, transcription factor binding (GO:0000989) 3.362ZFPM2, NKX2-5
transcription factor activity, protein binding (GO:0000988) 3.352ZFPM2, NKX2-5
double-stranded DNA binding (GO:0003690) 3.092GATA6, NKX2-5
metal ion binding (GO:0046872) 1.412GATA6, ZFPM2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942ZFPM2, NKX2-5
identical protein binding (GO:0042802) 2.632TBX1, NKX2-5
protein homodimerization activity (GO:0042803) 3.162TBX1, NKX2-5
regulatory region nucleic acid binding (GO:0001067) 3.032GATA6, NKX2-5
RNA polymerase II transcription cofactor activity (GO:0001104) 5.222ZFPM2, NKX2-5
transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190) 5.772ZFPM2, NKX2-5
RNA polymerase II transcription factor binding (GO:0001085) 5.082GATA6, ZFPM2
transcription regulatory region DNA binding (GO:0044212) 3.032GATA6, NKX2-5
transcriptional repressor activity, RNA polymerase II activating transcription factor binding (GO:0098811) 5.772ZFPM2, NKX2-5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232GATA6, NKX2-5
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242GATA6, NKX2-5
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372GATA6, NKX2-5
regulatory region DNA binding (GO:0000975) 3.032GATA6, NKX2-5
protein dimerization activity (GO:0046983) 2.722TBX1, NKX2-5
chromatin binding (GO:0003682) 3.642GATA6, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) -2.790.003NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190) -5.770.004ZFPM2, NKX2-5
sequence-specific DNA binding transcription factor activity (GO:0003700) -2.650.044NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
transcription factor binding (GO:0008134) -3.460.018ZFPM2, GATA6, TBX1, NKX2-5
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) -5.230.006GATA6, TBX1, NKX2-5
RNA polymerase II transcription cofactor activity (GO:0001104) -5.220.016ZFPM2, NKX2-5
RNA polymerase II transcription coactivator activity (GO:0001105) NEW6.150.013ZFPM2, NKX2-5
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) -4.840.033ZFPM2, NKX2-5
nucleic acid binding transcription factor activity (GO:0001071) -2.650.012NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
DNA binding (GO:0003677) -1.920.016NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
chromatin binding (GO:0003682) -3.640.022ZFPM2, GATA6, TBX1, NKX2-5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of RNA metabolic process (GO:0051252) 1.526ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of primary metabolic process (GO:0080090) 1.086ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of metabolic process (GO:0019222) 1.026ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of cellular biosynthetic process (GO:0031326) 1.386ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of cellular metabolic process (GO:0031323) 1.076ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of cell death (GO:0010941) 2.436ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of biological process (GO:0050789) 0.456ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
single-organism process (GO:0044699) 0.486ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
cellular developmental process (GO:0048869) 1.826ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.466ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of macromolecule metabolic process (GO:0060255) 1.086ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
biological regulation (GO:0065007) 0.396ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
positive regulation of biological process (GO:0048518) 1.26ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of gene expression (GO:0010468) 1.376ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
developmental process (GO:0032502) 1.366ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
cellular process (GO:0009987) 0.266ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of biosynthetic process (GO:0009889) 1.376ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of nucleic acid-templated transcription (GO:1903506) 1.556ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of cellular process (GO:0050794) 0.56ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
single-organism developmental process (GO:0044767) 1.496ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
single-organism cellular process (GO:0044763) 0.656ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of nitrogen compound metabolic process (GO:0051171) 1.366ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of RNA biosynthetic process (GO:2001141) 1.556ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
anatomical structure development (GO:0048856) 1.586ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of transcription, DNA-templated (GO:0006355) 1.566ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
regulation of macromolecule biosynthetic process (GO:0010556) 1.436ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
positive regulation of cellular process (GO:0048522) 1.36ZFPM2, GDF1, NKX2-5, GATA6, NKX2-6, TBX1
positive regulation of metabolic process (GO:0009893) 1.745GATA6, GDF1, ZFPM2, TBX1, NKX2-5
positive regulation of cellular metabolic process (GO:0031325) 1.815ZFPM2, GDF1, GATA6, TBX1, NKX2-5
cell differentiation (GO:0030154) 2.145NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nucleic acid metabolic process (GO:0090304) 1.465NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
cellular biosynthetic process (GO:0044249) 1.375NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
cellular nitrogen compound metabolic process (GO:0034641) 1.225NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nitrogen compound metabolic process (GO:0006807) 1.135NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
cellular macromolecule biosynthetic process (GO:0034645) 1.665NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
regulation of apoptotic process (GO:0042981) 2.55NKX2-5, GATA6, GDF1, TBX1, NKX2-6
multicellular organism development (GO:0007275) 2.545NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
nucleic acid-templated transcription (GO:0097659) 1.915NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
RNA biosynthetic process (GO:0032774) 1.845NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nucleobase-containing compound metabolic process (GO:0006139) 1.355NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
positive regulation of macromolecule metabolic process (GO:0010604) 1.815ZFPM2, GDF1, GATA6, TBX1, NKX2-5
cellular macromolecule metabolic process (GO:0044260) 0.935NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
organic cyclic compound biosynthetic process (GO:1901362) 1.665NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
organic substance metabolic process (GO:0071704) 0.635NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
regulation of programmed cell death (GO:0043067) 2.495NKX2-5, GATA6, GDF1, TBX1, NKX2-6
animal organ development (GO:0048513) 2.535NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
organic cyclic compound metabolic process (GO:1901360) 1.265NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
negative regulation of biological process (GO:0048519) 1.335NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
heterocycle biosynthetic process (GO:0018130) 1.75NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
multicellular organismal process (GO:0032501) 1.455NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
organic substance biosynthetic process (GO:1901576) 1.345NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
negative regulation of cell death (GO:0060548) 2.955NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
cellular aromatic compound metabolic process (GO:0006725) 1.35NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
tissue development (GO:0009888) 3.275NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
biosynthetic process (GO:0009058) 1.325NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
macromolecule biosynthetic process (GO:0009059) 1.615NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
metabolic process (GO:0008152) 0.585NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nucleobase-containing compound biosynthetic process (GO:0034654) 1.725NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
heterocycle metabolic process (GO:0046483) 1.315NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
RNA metabolic process (GO:0016070) 1.595NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
primary metabolic process (GO:0044238) 0.695NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
single-multicellular organism process (GO:0044707) 1.785NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
cellular metabolic process (GO:0044237) 0.695NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
macromolecule metabolic process (GO:0043170) 0.835NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.245GATA6, GDF1, ZFPM2, TBX1, NKX2-5
transcription, DNA-templated (GO:0006351) 1.915NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
aromatic compound biosynthetic process (GO:0019438) 1.75NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
negative regulation of cellular process (GO:0048523) 1.415NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
regulation of cell proliferation (GO:0042127) 2.414GATA6, TBX1, NKX2-6, NKX2-5
positive regulation of biosynthetic process (GO:0009891) 2.294GATA6, ZFPM2, TBX1, NKX2-5
cell development (GO:0048468) 3.284GATA6, GDF1, NKX2-6, NKX2-5
positive regulation of gene expression (GO:0010628) 2.354GATA6, ZFPM2, TBX1, NKX2-5
regulation of signaling (GO:0023051) 1.724GATA6, GDF1, TBX1, NKX2-5
anatomical structure morphogenesis (GO:0009653) 2.534ZFPM2, GATA6, TBX1, NKX2-5
regulation of cell communication (GO:0010646) 1.734GATA6, GDF1, TBX1, NKX2-5
regulation of signal transduction (GO:0009966) 1.844GATA6, GDF1, TBX1, NKX2-5
positive regulation of multicellular organismal process (GO:0051240) 2.494ZFPM2, GATA6, TBX1, NKX2-5
positive regulation of cellular biosynthetic process (GO:0031328) 2.34GATA6, ZFPM2, TBX1, NKX2-5
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564ZFPM2, GATA6, TBX1, NKX2-5
negative regulation of apoptotic process (GO:0043066) 3.044GATA6, TBX1, NKX2-6, NKX2-5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814GATA6, ZFPM2, TBX1, NKX2-5
negative regulation of programmed cell death (GO:0043069) 3.024GATA6, TBX1, NKX2-6, NKX2-5
positive regulation of cell proliferation (GO:0008284) 3.014GATA6, TBX1, NKX2-6, NKX2-5
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354ZFPM2, GATA6, TBX1, NKX2-5
regulation of developmental process (GO:0050793) 2.14GATA6, ZFPM2, TBX1, NKX2-5
regulation of response to stimulus (GO:0048583) 1.544GATA6, GDF1, TBX1, NKX2-5
regulation of cell differentiation (GO:0045595) 2.424GATA6, ZFPM2, TBX1, NKX2-5
positive regulation of transcription, DNA-templated (GO:0045893) 2.564GATA6, ZFPM2, TBX1, NKX2-5
regulation of multicellular organismal process (GO:0051239) 1.874ZFPM2, GATA6, TBX1, NKX2-5
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294GATA6, ZFPM2, TBX1, NKX2-5
heart development (GO:0007507) 4.244ZFPM2, TBX1, NKX2-6, NKX2-5
positive regulation of developmental process (GO:0051094) 2.774ZFPM2, GATA6, TBX1, NKX2-5
outflow tract septum morphogenesis (GO:0003148) 7.094ZFPM2, GATA6, TBX1, NKX2-5
positive regulation of RNA metabolic process (GO:0051254) 2.514GATA6, ZFPM2, TBX1, NKX2-5
positive regulation of RNA biosynthetic process (GO:1902680) 2.544ZFPM2, GATA6, TBX1, NKX2-5
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394GATA6, ZFPM2, TBX1, NKX2-5
regulation of multicellular organismal development (GO:2000026) 2.314GATA6, ZFPM2, TBX1, NKX2-5
cardiac septum morphogenesis (GO:0060411) 5.94ZFPM2, GATA6, TBX1, NKX2-5
negative regulation of metabolic process (GO:0009892) 1.933ZFPM2, GATA6, NKX2-5
negative regulation of biosynthetic process (GO:0009890) 2.473ZFPM2, GATA6, NKX2-5
negative regulation of cellular biosynthetic process (GO:0031327) 2.493GATA6, ZFPM2, NKX2-5
positive regulation of response to stimulus (GO:0048584) 2.183GATA6, GDF1, TBX1
regulation of muscle organ development (GO:0048634) 5.073GATA6, TBX1, NKX2-5
positive regulation of signaling (GO:0023056) 2.413GATA6, GDF1, TBX1
negative regulation of gene expression (GO:0010629) 2.483ZFPM2, GATA6, NKX2-5
signal transduction (GO:0007165) 1.283GDF1, TBX1, NKX2-5
positive regulation of cell communication (GO:0010647) 2.413GATA6, GDF1, TBX1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013GATA6, ZFPM2, NKX2-5
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123GATA6, ZFPM2, NKX2-5
positive regulation of signal transduction (GO:0009967) 2.53GATA6, GDF1, TBX1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63GATA6, ZFPM2, NKX2-5
tissue morphogenesis (GO:0048729) 3.873ZFPM2, TBX1, NKX2-5
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013GATA6, TBX1, NKX2-5
regulation of muscle tissue development (GO:1901861) 5.073GATA6, TBX1, NKX2-5
regulation of striated muscle tissue development (GO:0016202) 5.093GATA6, TBX1, NKX2-5
negative regulation of cellular metabolic process (GO:0031324) 2.013GATA6, ZFPM2, NKX2-5
tube morphogenesis (GO:0035239) 4.353GATA6, TBX1, NKX2-5
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553ZFPM2, GATA6, NKX2-5
pharyngeal system development (GO:0060037) 6.963TBX1, NKX2-5, NKX2-6
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713ZFPM2, GATA6, NKX2-5
negative regulation of RNA biosynthetic process (GO:1902679) 2.73ZFPM2, GATA6, NKX2-5
negative regulation of cell differentiation (GO:0045596) 3.333ZFPM2, TBX1, NKX2-5
negative regulation of transcription, DNA-templated (GO:0045892) 2.753ZFPM2, GATA6, NKX2-5
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473ZFPM2, GATA6, NKX2-5
system process (GO:0003008) 2.33GATA6, TBX1, NKX2-5
positive regulation of cell differentiation (GO:0045597) 3.013GATA6, TBX1, NKX2-5
cell fate commitment (GO:0045165) 4.723GATA6, TBX1, NKX2-5
negative regulation of RNA metabolic process (GO:0051253) 2.663ZFPM2, GATA6, NKX2-5
striated muscle tissue development (GO:0014706) 5.233GATA6, ZFPM2, NKX2-5
cardiac muscle tissue development (GO:0048738) 6.333ZFPM2, GATA6, NKX2-5
muscle tissue development (GO:0060537) 5.13ZFPM2, GATA6, NKX2-5
system development (GO:0048731) 2.923TBX1, NKX2-5, NKX2-6
gland development (GO:0048732) 4.153GATA6, TBX1, NKX2-5
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533ZFPM2, GATA6, NKX2-5
muscle tissue morphogenesis (GO:0060415) 5.623ZFPM2, TBX1, NKX2-5
regulation of phosphate metabolic process (GO:0019220) 2.352GDF1, TBX1
positive regulation of stem cell differentiation (GO:2000738) 7.022GATA6, NKX2-5
blood coagulation (GO:0007596) 4.522GATA6, ZFPM2
BMP signaling pathway (GO:0030509) 5.332GDF1, NKX2-5
muscle system process (GO:0003012) 4.182GATA6, NKX2-5
cell surface receptor signaling pathway (GO:0007166) 2.092GDF1, NKX2-5
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242GDF1, NKX2-5
hemostasis (GO:0007599) 4.52GATA6, ZFPM2
positive regulation of cardioblast differentiation (GO:0051891) 8.122GATA6, NKX2-5
regulation of cardioblast differentiation (GO:0051890) 7.782GATA6, NKX2-5
outflow tract morphogenesis (GO:0003151) 5.972TBX1, NKX2-5
cellular response to stimulus (GO:0051716) 1.972GATA6, TBX1
response to growth factor (GO:0070848) 4.142GATA6, TBX1
epithelial cell differentiation (GO:0030855) 3.982GATA6, TBX1
(GO:1905207) 6.42GATA6, NKX2-5
(GO:1905209) 6.732GATA6, NKX2-5
heart morphogenesis (GO:0003007) 5.842TBX1, NKX2-5
developmental process involved in reproduction (GO:0003006) 3.362GATA6, ZFPM2
regionalization (GO:0003002) 4.242TBX1, NKX2-5
response to organic substance (GO:0010033) 2.22GATA6, TBX1
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62GDF1, NKX2-5
regulation of phosphorylation (GO:0042325) 2.52GDF1, TBX1
positive regulation of phosphorylation (GO:0042327) 2.92GDF1, TBX1
ventricular septum morphogenesis (GO:0060412) 6.592ZFPM2, NKX2-5
muscle cell fate commitment (GO:0042693) 7.332TBX1, NKX2-5
muscle cell differentiation (GO:0042692) 5.092GATA6, NKX2-5
positive regulation of striated muscle tissue development (GO:0045844) 5.692GATA6, TBX1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792GATA6, TBX1
regulation of cardiac muscle cell proliferation (GO:0060043) 6.332GATA6, NKX2-5
organ morphogenesis (GO:0009887) 3.552TBX1, NKX2-5
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122GATA6, GDF1
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) 9.042ZFPM2, NKX2-5
transcription from RNA polymerase II promoter (GO:0006366) 3.382GATA6, NKX2-5
regulation of biological quality (GO:0065008) 1.682GATA6, ZFPM2
thyroid gland development (GO:0030878) 6.472TBX1, NKX2-5
positive regulation of muscle tissue development (GO:1901863) 5.672GATA6, TBX1
regulation of cardiac muscle tissue development (GO:0055024) 5.862GATA6, NKX2-5
regulation of cardiac muscle tissue growth (GO:0055021) 6.122GATA6, NKX2-5
programmed cell death (GO:0012501) 3.12TBX1, NKX2-5
coagulation (GO:0050817) 4.512ZFPM2, GATA6
regulation of intracellular signal transduction (GO:1902531) 2.312GDF1, TBX1
vasculogenesis (GO:0001570) 5.652ZFPM2, NKX2-5
response to stimulus (GO:0050896) 1.222GATA6, TBX1
positive regulation of protein modification process (GO:0031401) 2.72GDF1, TBX1
regulation of developmental growth (GO:0048638) 4.042GATA6, NKX2-5
mesoderm development (GO:0007498) 5.722ZFPM2, TBX1
positive regulation of muscle organ development (GO:0048636) 5.692GATA6, TBX1
embryo development (GO:0009790) 4.22ZFPM2, GATA6
embryo development ending in birth or egg hatching (GO:0009792) 4.352ZFPM2, GATA6
cellular response to chemical stimulus (GO:0070887) 2.572GATA6, TBX1
mesenchyme development (GO:0060485) 5.72ZFPM2, NKX2-5
regulation of stem cell differentiation (GO:2000736) 6.262GATA6, NKX2-5
regulation of MAPK cascade (GO:0043408) 3.222GDF1, TBX1
response to endogenous stimulus (GO:0009719) 2.792GATA6, TBX1
in utero embryonic development (GO:0001701) 4.42ZFPM2, GATA6
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GDF1, TBX1
negative regulation of multicellular organismal process (GO:0051241) 2.842GATA6, ZFPM2
regulation of protein metabolic process (GO:0051246) 1.932GDF1, TBX1
positive regulation of protein metabolic process (GO:0051247) 2.432GDF1, TBX1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492GDF1, TBX1
regulation of protein modification process (GO:0031399) 2.322GDF1, TBX1
chordate embryonic development (GO:0043009) 4.382ZFPM2, GATA6
cellular response to endogenous stimulus (GO:0071495) 3.332GATA6, TBX1
muscle cell development (GO:0055001) 5.292NKX2-5, NKX2-6
striated muscle cell development (GO:0055002) 5.422NKX2-5, NKX2-6
reproductive structure development (GO:0048608) 4.082ZFPM2, GATA6
cardiac cell development (GO:0055006) 6.332NKX2-5, NKX2-6
cardiac muscle cell differentiation (GO:0055007) 6.292GATA6, NKX2-5
cardiac muscle tissue morphogenesis (GO:0055008) 5.82ZFPM2, NKX2-5
epithelium development (GO:0060429) 4.572NKX2-5, NKX2-6
regulation of striated muscle cell differentiation (GO:0051153) 5.262TBX1, NKX2-5
regulation of myotube differentiation (GO:0010830) 5.692TBX1, NKX2-5
negative regulation of developmental process (GO:0051093) 3.172ZFPM2, NKX2-5
regulation of cellular protein metabolic process (GO:0032268) 1.992GDF1, TBX1
cellular response to growth factor stimulus (GO:0071363) 4.272GATA6, TBX1
ventricular cardiac muscle cell development (GO:0055015) 7.332NKX2-5, NKX2-6
atrial cardiac muscle cell development (GO:0055014) 8.632NKX2-5, NKX2-6
cardiac muscle cell development (GO:0055013) 6.42NKX2-5, NKX2-6
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.072ZFPM2, NKX2-5
regulation of heart growth (GO:0060420) 5.972GATA6, NKX2-5
regulation of muscle cell differentiation (GO:0051147) 4.682TBX1, NKX2-5
striated muscle cell differentiation (GO:0051146) 5.692GATA6, NKX2-5
cell death (GO:0008219) 3.052TBX1, NKX2-5
pattern specification process (GO:0007389) 3.792TBX1, NKX2-5
regulation of body fluid levels (GO:0050878) 3.762GATA6, ZFPM2
regulation of growth (GO:0040008) 3.262GATA6, NKX2-5
cell proliferation (GO:0008283) 3.232TBX1, NKX2-5
cellular response to organic substance (GO:0071310) 2.782GATA6, TBX1
hematopoietic or lymphoid organ development (GO:0048534) 4.492TBX1, NKX2-5
embryonic morphogenesis (GO:0048598) 3.722TBX1, NKX2-5
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392GATA6, GDF1
positive regulation of phosphate metabolic process (GO:0045937) 2.782GDF1, TBX1
regulation of organ growth (GO:0046620) 5.412GATA6, NKX2-5
apoptotic process (GO:0006915) 3.142TBX1, NKX2-5
cardiocyte differentiation (GO:0035051) 6.022GATA6, NKX2-5
embryonic heart tube development (GO:0035050) 6.732NKX2-5, NKX2-6
regulation of phosphorus metabolic process (GO:0051174) 2.352GDF1, TBX1
reproductive process (GO:0022414) 2.552GATA6, ZFPM2
response to chemical (GO:0042221) 1.982GATA6, TBX1
tube development (GO:0035295) 4.412NKX2-5, NKX2-6
regulation of protein phosphorylation (GO:0001932) 2.572GDF1, TBX1
positive regulation of protein phosphorylation (GO:0001934) 2.952GDF1, TBX1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of muscle tissue development (GO:1901861) -5.070.003GATA6, TBX1, NKX2-5
ventricular cardiac muscle cell development (GO:0055015) -7.330.017NKX2-5, NKX2-6
atrial cardiac muscle cell development (GO:0055014) -8.630.0NKX2-5, NKX2-6
cardiac muscle cell development (GO:0055013) -6.40.023NKX2-5, NKX2-6
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.034ZFPM2, NKX2-5
mesoderm development (GO:0007498) -5.720.007ZFPM2, TBX1, NKX2-5
positive regulation of stem cell differentiation (GO:2000738) -7.020.004GATA6, NKX2-5
cell differentiation (GO:0030154) -2.140.017NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
regulation of muscle organ development (GO:0048634) -5.070.003GATA6, TBX1, NKX2-5
embryo development ending in birth or egg hatching (GO:0009792) -4.350.027GATA6, ZFPM2, TBX1, NKX2-5
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.023GATA6, NKX2-5
negative regulation of transcription by transcription factor localization (GO:0010621) NEW8.630.001GATA6, NKX2-5
regulation of cardioblast differentiation (GO:0051890) -7.780.002GATA6, NKX2-5
positive regulation of cardioblast differentiation (GO:0051891) -8.120.0GATA6, NKX2-5
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) -9.040.0ZFPM2, NKX2-5
outflow tract morphogenesis (GO:0003151) -5.970.004GATA6, TBX1, NKX2-5
regulation of male gonad development (GO:2000018) NEW7.530.015GATA6, ZFPM2
organ development (GO:0048513) -2.530.003NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
chordate embryonic development (GO:0043009) -4.380.024GATA6, ZFPM2, TBX1, NKX2-5
negative regulation of programmed cell death (GO:0043069) -3.020.015GATA6, TBX1, NKX2-6, NKX2-5
positive regulation of cell proliferation (GO:0008284) -3.010.022GATA6, TBX1, NKX2-6, NKX2-5
regulation of striated muscle tissue development (GO:0016202) -5.090.003GATA6, TBX1, NKX2-5
regulation of heart growth (GO:0060420) -5.970.042GATA6, NKX2-5
tube morphogenesis (GO:0035239) -4.350.002GATA6, TBX1, NKX2-5
cardiac cell development (GO:0055006) -6.330.026NKX2-5, NKX2-6
cardiac muscle cell differentiation (GO:0055007) -6.290.02GATA6, NKX2-5
negative regulation of cell death (GO:0060548) -2.950.0NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
pharyngeal system development (GO:0060037) -6.960.0TBX1, NKX2-5, NKX2-6
cardiocyte differentiation (GO:0035051) -6.020.038GATA6, NKX2-5
tissue development (GO:0009888) -3.270.01ZFPM2, TBX1, NKX2-6, NKX2-5
embryonic heart tube development (GO:0035050) -6.730.04NKX2-5, NKX2-6
heart morphogenesis (GO:0003007) -5.840.033TBX1, NKX2-5
in utero embryonic development (GO:0001701) -4.40.022GATA6, ZFPM2, TBX1, NKX2-5
negative regulation of apoptotic process (GO:0043066) -3.040.014GATA6, TBX1, NKX2-6, NKX2-5
mesenchyme development (GO:0060485) -5.70.006ZFPM2, GATA6, NKX2-5
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.033GATA6, NKX2-5
cardiac septum morphogenesis (GO:0060411) -5.90.0ZFPM2, GATA6, TBX1, NKX2-5
vasculogenesis (GO:0001570) -5.650.019ZFPM2, GATA6, NKX2-5
positive regulation of developmental process (GO:0051094) -2.770.031ZFPM2, GATA6, TBX1, NKX2-5
thyroid gland development (GO:0030878) -6.470.008TBX1, NKX2-5
outflow tract septum morphogenesis (GO:0003148) -7.090.0ZFPM2, GATA6, TBX1, NKX2-5
regulation of cell death (GO:0010941) -2.430.007NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
gland development (GO:0048732) -4.150.017GATA6, TBX1, NKX2-5
cardiac muscle tissue development (GO:0048738) -6.330.014ZFPM2, NKX2-5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) -2.810.036GATA6, ZFPM2, TBX1, NKX2-5
ventricular septum morphogenesis (GO:0060412) -6.590.009ZFPM2, NKX2-5
muscle cell fate commitment (GO:0042693) -7.330.009TBX1, NKX2-5
muscle tissue morphogenesis (GO:0060415) -5.620.0ZFPM2, TBX1, NKX2-5
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.65NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
nucleus (GO:0005634) 1.075NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
cell part (GO:0044464) 0.115NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
intracellular organelle (GO:0043229) 0.515NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
intracellular part (GO:0044424) 0.285NKX2-5, ZFPM2, GATA6, TBX1, NKX2-6
membrane-bounded organelle (GO:0043227) 0.475NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
organelle (GO:0043226) 0.45NKX2-5, GATA6, ZFPM2, TBX1, NKX2-6
intracellular organelle part (GO:0044446) 0.813GATA6, ZFPM2, NKX2-5
nuclear part (GO:0044428) 1.553ZFPM2, GATA6, NKX2-5
organelle part (GO:0044422) 0.793ZFPM2, GATA6, NKX2-5
cytoplasm (GO:0005737) 1.012ZFPM2, NKX2-5
nucleoplasm (GO:0005654) 1.892ZFPM2, GATA6
protein complex (GO:0043234) 1.512GATA6, NKX2-5
macromolecular complex (GO:0032991) 1.352GATA6, NKX2-5
transcription factor complex (GO:0005667) 4.12GATA6, NKX2-5