Disease table of ATRIOVENTRICULAR SEPTAL DEFECT OMIM ID: PS606215

Gene-disease associations table

GeneAssociated with ATRIOVENTRICULAR SEPTAL DEFECT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GATA6ClinVar, OMIM, HUMSAVARHGNC link18q11.25600001, PS108800, 217095, PS606215, 187500
GJA1ClinVar, OMIM, HUMSAVARHGNC link6q22.318257850, 186100, 164200, 133200, 104100, PS606215, 218400, PS241550
GATA4ClinVar, OMIM, HUMSAVARHGNC link8p23.15PS614429, PS108800, 615542, PS606215, 187500
CRELD1ClinVar, OMIM, HUMSAVARHGNC link3p25.31PS606215
FOXP1ClinVarHGNC link3p133PS606215, PS241550, 613670

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
3p2FOXP1, CRELD1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
32FOXP1, CRELD1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
GATA6YES9DKK1, PLAU, CYP17A1, APOA1, CAV1, CYP11A1, VWF, SULT2A1, DAB20
GATA4YES22NKX2-5, FGF10, HDAC9, CYP17A1, NOS3, CCND2, BMP4, HESX1, HAMP, FCGR3B, STAR, ERBB2, FABP2, IAPP, NPPA, AMH, SUMO1, NPPB, IL5, SGPL1, FCGR2B, MEF2C0
FOXP1YES2KLK3, RAG10
NANOGNO23GATA4, GATA2, FGF4, CGB, GDF3, AFP, POU5F1, GATA6, CGA, KDR, LAMB1, L1TD1, MTF2, DKK1, CDC25A, SEMA6A, SOX1, YES1, LXN, CDK6, CDX2, CCND1, KLF22GATA6, GATA4
HEY2NO3GATA6, GATA4, ACTA22GATA6, GATA4
HEY1NO9GATA6, PROX1, ACTA2, GATA4, CCL2, BMP2, KDR, TNFRSF12A, OCLN2GATA6, GATA4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GATA6YES4HEY2, HEY1, NANOG, POU5F10
GJA1YES2SP1, JUN0
GATA4YES4HEY2, HEY1, NKX2-5, NANOG0
FOXP1YES1ESR10
CYP17A1NO12SP1, NR5A1, PIAS1, GATA4, GATA6, NFIC, NR2F1, NR4A1, CREB1, NR0B1, SP3, SMAD32GATA6, GATA4
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
GATA6GATA4No2SP1, EP300

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GATA6GJA1No-1MYOCD
GATA6GATA4Yesactivation, binding15SP1, ZFPM2, ZFPM1, NKX2-1, KLF13, HEY2, HEY1, STAR, CYP17A1, CDK9, MYOCD, SMAD2, BMP2, GATA3, EP300
GJA1GATA4No-6GJA5, JUN, MYOCD, BMP7, FOS, EDN1
GATA4FOXP1No-1NFATC4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Proteoglycans in cancer (hsa05205) NEW5.020.042GATA6, GATA4, GJA1
MicroRNAs in cancer (hsa05206) NEW5.380.017GATA6, FOXP1, GATA4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882GATA6, GATA4
HemostasisR-HSA-1095823.982GATA6, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
Gap junction trafficking and regulation (R-HSA-157858) NEW7.520.031GATA4, GJA1
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) -5.880.019GATA6, GATA4
Gap junction trafficking (R-HSA-190828) NEW7.590.03GATA4, GJA1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185CRELD1, GATA6, FOXP1, GATA4, GJA1
cation binding (GO:0043169) 1.44GATA6, FOXP1, CRELD1, GATA4
metal ion binding (GO:0046872) 1.414GATA6, FOXP1, CRELD1, GATA4
protein binding (GO:0005515) 0.464GATA6, FOXP1, GATA4, GJA1
ion binding (GO:0043167) 1.364GATA6, FOXP1, CRELD1, GATA4
sequence-specific DNA binding (GO:0043565) 2.793GATA6, FOXP1, GATA4
sequence-specific double-stranded DNA binding (GO:1990837) 3.23GATA6, FOXP1, GATA4
transcription regulatory region DNA binding (GO:0044212) 3.033GATA6, FOXP1, GATA4
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653GATA6, FOXP1, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.363GATA6, FOXP1, GATA4
regulatory region DNA binding (GO:0000975) 3.033GATA6, FOXP1, GATA4
regulatory region nucleic acid binding (GO:0001067) 3.033GATA6, FOXP1, GATA4
macromolecular complex binding (GO:0044877) 2.613GATA6, FOXP1, GATA4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.373GATA6, FOXP1, GATA4
nucleic acid binding (GO:0003676) 1.443GATA6, FOXP1, GATA4
DNA binding (GO:0003677) 1.923GATA6, FOXP1, GATA4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.243GATA6, FOXP1, GATA4
double-stranded DNA binding (GO:0003690) 3.093GATA6, FOXP1, GATA4
chromatin binding (GO:0003682) 3.643GATA6, FOXP1, GATA4
organic cyclic compound binding (GO:0097159) 1.053GATA6, FOXP1, GATA4
heterocyclic compound binding (GO:1901363) 1.063GATA6, FOXP1, GATA4
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.293GATA6, FOXP1, GATA4
nucleic acid binding transcription factor activity (GO:0001071) 2.653GATA6, FOXP1, GATA4
RNA polymerase II transcription factor binding (GO:0001085) 5.082GATA6, GATA4
transition metal ion binding (GO:0046914) 2.482GATA6, GATA4
transcription factor binding (GO:0008134) 3.462GATA6, GATA4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982GATA6, GATA4
enzyme binding (GO:0019899) 2.272GATA6, GATA4
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232GATA6, FOXP1
protein kinase binding (GO:0019901) 3.442GATA6, GATA4
kinase binding (GO:0019900) 3.322GATA6, GATA4
zinc ion binding (GO:0008270) 2.662GATA6, GATA4
receptor binding (GO:0005102) 2.432FOXP1, GJA1

NET-GE enrichment

Term New enriched termICP valueGenes
kinase regulator activity (GO:0019207) NEW4.50.027GATA6, GATA4, GJA1
protein kinase regulator activity (GO:0019887) NEW4.60.016GATA6, GATA4, GJA1
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) -5.230.007GATA6, FOXP1, GATA4
iron ion binding (GO:0005506) NEW4.650.033GATA6, FOXP1, GATA4
chromatin binding (GO:0003682) -3.640.008GATA6, FOXP1, GATA4
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.007GATA6, FOXP1, GATA4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism developmental process (GO:0044767) 1.495CRELD1, GATA6, FOXP1, GATA4, GJA1
developmental process (GO:0032502) 1.365CRELD1, GATA6, FOXP1, GATA4, GJA1
anatomical structure development (GO:0048856) 1.585CRELD1, GATA6, FOXP1, GATA4, GJA1
tissue development (GO:0009888) 3.275CRELD1, GATA6, FOXP1, GATA4, GJA1
single-organism process (GO:0044699) 0.485CRELD1, GATA6, FOXP1, GATA4, GJA1
positive regulation of metabolic process (GO:0009893) 1.744GATA6, FOXP1, GATA4, GJA1
regulation of metabolic process (GO:0019222) 1.024GATA6, FOXP1, GATA4, GJA1
regulation of cellular biosynthetic process (GO:0031326) 1.384GATA6, FOXP1, GATA4, GJA1
cell differentiation (GO:0030154) 2.144GATA6, FOXP1, GATA4, GJA1
regulation of response to stimulus (GO:0048583) 1.544GATA6, FOXP1, GATA4, GJA1
positive regulation of gene expression (GO:0010628) 2.354GATA6, FOXP1, GATA4, GJA1
regulation of signaling (GO:0023051) 1.724GATA6, FOXP1, GATA4, GJA1
regulation of cell communication (GO:0010646) 1.734GATA6, FOXP1, GATA4, GJA1
regulation of biological process (GO:0050789) 0.454GATA6, FOXP1, GATA4, GJA1
regulation of primary metabolic process (GO:0080090) 1.084GATA6, FOXP1, GATA4, GJA1
positive regulation of macromolecule metabolic process (GO:0010604) 1.814GATA6, FOXP1, GATA4, GJA1
regulation of signal transduction (GO:0009966) 1.844GATA6, FOXP1, GATA4, GJA1
cellular developmental process (GO:0048869) 1.824GATA6, FOXP1, GATA4, GJA1
positive regulation of multicellular organismal process (GO:0051240) 2.494GATA6, FOXP1, GATA4, GJA1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464GATA6, FOXP1, GATA4, GJA1
regulation of developmental process (GO:0050793) 2.14GATA6, FOXP1, GATA4, GJA1
animal organ development (GO:0048513) 2.534GATA6, FOXP1, GATA4, GJA1
biological regulation (GO:0065007) 0.394GATA6, FOXP1, GATA4, GJA1
positive regulation of biological process (GO:0048518) 1.24GATA6, FOXP1, GATA4, GJA1
negative regulation of biological process (GO:0048519) 1.334GATA6, FOXP1, GATA4, GJA1
regulation of gene expression (GO:0010468) 1.374GATA6, FOXP1, GATA4, GJA1
multicellular organismal process (GO:0032501) 1.454GATA6, FOXP1, GATA4, GJA1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434GATA6, FOXP1, GATA4, GJA1
regulation of cellular metabolic process (GO:0031323) 1.074GATA6, FOXP1, GATA4, GJA1
cellular process (GO:0009987) 0.264GATA6, FOXP1, GATA4, GJA1
regulation of biosynthetic process (GO:0009889) 1.374GATA6, FOXP1, GATA4, GJA1
regulation of cellular process (GO:0050794) 0.54GATA6, FOXP1, GATA4, GJA1
positive regulation of cell differentiation (GO:0045597) 3.014GATA6, FOXP1, GATA4, GJA1
regulation of cell differentiation (GO:0045595) 2.424GATA6, FOXP1, GATA4, GJA1
single-organism cellular process (GO:0044763) 0.654GATA6, FOXP1, GATA4, GJA1
regulation of nitrogen compound metabolic process (GO:0051171) 1.364GATA6, FOXP1, GATA4, GJA1
regulation of multicellular organismal process (GO:0051239) 1.874GATA6, FOXP1, GATA4, GJA1
response to chemical (GO:0042221) 1.984GATA6, FOXP1, GATA4, GJA1
response to organic substance (GO:0010033) 2.24GATA6, FOXP1, GATA4, GJA1
single-multicellular organism process (GO:0044707) 1.784GATA6, FOXP1, GATA4, GJA1
positive regulation of developmental process (GO:0051094) 2.774GATA6, FOXP1, GATA4, GJA1
regulation of macromolecule metabolic process (GO:0060255) 1.084GATA6, FOXP1, GATA4, GJA1
response to stimulus (GO:0050896) 1.224GATA6, FOXP1, GATA4, GJA1
regulation of macromolecule biosynthetic process (GO:0010556) 1.434GATA6, FOXP1, GATA4, GJA1
regulation of multicellular organismal development (GO:2000026) 2.314GATA6, FOXP1, GATA4, GJA1
negative regulation of cellular process (GO:0048523) 1.414GATA6, FOXP1, GATA4, GJA1
positive regulation of cellular process (GO:0048522) 1.34GATA6, FOXP1, GATA4, GJA1
response to abiotic stimulus (GO:0009628) 2.83GATA6, GATA4, GJA1
positive regulation of response to stimulus (GO:0048584) 2.183GATA6, GATA4, GJA1
cell development (GO:0048468) 3.283GATA6, FOXP1, GATA4
organic cyclic compound biosynthetic process (GO:1901362) 1.663GATA6, FOXP1, GATA4
organic cyclic compound metabolic process (GO:1901360) 1.263GATA6, FOXP1, GATA4
cellular response to stimulus (GO:0051716) 1.973GATA6, GATA4, GJA1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013GATA6, FOXP1, GJA1
positive regulation of signal transduction (GO:0009967) 2.53GATA6, GATA4, GJA1
epithelial cell differentiation (GO:0030855) 3.983GATA6, FOXP1, GATA4
regulation of cell proliferation (GO:0042127) 2.413GATA6, FOXP1, GJA1
regulation of striated muscle tissue development (GO:0016202) 5.093GATA6, FOXP1, GJA1
(GO:1905207) 6.43GATA6, FOXP1, GATA4
(GO:1905209) 6.733GATA6, FOXP1, GATA4
regulation of RNA biosynthetic process (GO:2001141) 1.553GATA6, FOXP1, GATA4
heterocycle metabolic process (GO:0046483) 1.313GATA6, FOXP1, GATA4
response to external stimulus (GO:0009605) 2.553FOXP1, GATA4, GJA1
embryo development (GO:0009790) 4.23GATA6, FOXP1, GJA1
aromatic compound biosynthetic process (GO:0019438) 1.73GATA6, FOXP1, GATA4
muscle cell differentiation (GO:0042692) 5.093GATA6, FOXP1, GATA4
negative regulation of metabolic process (GO:0009892) 1.933GATA6, FOXP1, GJA1
positive regulation of striated muscle tissue development (GO:0045844) 5.693GATA6, FOXP1, GJA1
negative regulation of biosynthetic process (GO:0009890) 2.473GATA6, FOXP1, GJA1
positive regulation of biosynthetic process (GO:0009891) 2.293GATA6, FOXP1, GATA4
negative regulation of gene expression (GO:0010629) 2.483GATA6, FOXP1, GJA1
nitrogen compound metabolic process (GO:0006807) 1.133GATA6, FOXP1, GATA4
nucleic acid-templated transcription (GO:0097659) 1.913GATA6, FOXP1, GATA4
organic substance biosynthetic process (GO:1901576) 1.343GATA6, FOXP1, GATA4
cellular macromolecule metabolic process (GO:0044260) 0.933GATA6, FOXP1, GATA4
regulation of biological quality (GO:0065008) 1.683GATA6, GATA4, GJA1
regulation of anatomical structure morphogenesis (GO:0022603) 2.793GATA6, FOXP1, GATA4
heterocycle biosynthetic process (GO:0018130) 1.73GATA6, FOXP1, GATA4
regulation of muscle tissue development (GO:1901861) 5.073GATA6, FOXP1, GJA1
positive regulation of muscle tissue development (GO:1901863) 5.673GATA6, FOXP1, GJA1
regulation of cardiac muscle tissue development (GO:0055024) 5.863GATA6, FOXP1, GJA1
regulation of cardiac muscle tissue growth (GO:0055021) 6.123GATA6, FOXP1, GJA1
metabolic process (GO:0008152) 0.583GATA6, FOXP1, GATA4
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723GATA6, FOXP1, GATA4
RNA metabolic process (GO:0016070) 1.593GATA6, FOXP1, GATA4
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593GATA6, FOXP1, GATA4
regulation of transcription, DNA-templated (GO:0006355) 1.563GATA6, FOXP1, GATA4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393GATA6, FOXP1, GATA4
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243GATA6, FOXP1, GATA4
transcription, DNA-templated (GO:0006351) 1.913GATA6, FOXP1, GATA4
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533GATA6, FOXP1, GJA1
regulation of developmental growth (GO:0048638) 4.043GATA6, FOXP1, GJA1
RNA biosynthetic process (GO:0032774) 1.843GATA6, FOXP1, GATA4
regulation of muscle organ development (GO:0048634) 5.073GATA6, FOXP1, GJA1
positive regulation of muscle organ development (GO:0048636) 5.693GATA6, FOXP1, GJA1
positive regulation of signaling (GO:0023056) 2.413GATA6, GATA4, GJA1
cellular biosynthetic process (GO:0044249) 1.373GATA6, FOXP1, GATA4
cellular nitrogen compound metabolic process (GO:0034641) 1.223GATA6, FOXP1, GATA4
embryo development ending in birth or egg hatching (GO:0009792) 4.353GATA6, FOXP1, GJA1
cellular macromolecule biosynthetic process (GO:0034645) 1.663GATA6, FOXP1, GATA4
regulation of cardiac muscle cell proliferation (GO:0060043) 6.333GATA6, FOXP1, GJA1
positive regulation of cell communication (GO:0010647) 2.413GATA6, GATA4, GJA1
anatomical structure morphogenesis (GO:0009653) 2.533GATA6, GATA4, GJA1
nucleobase-containing compound metabolic process (GO:0006139) 1.353GATA6, FOXP1, GATA4
in utero embryonic development (GO:0001701) 4.43GATA6, FOXP1, GJA1
negative regulation of multicellular organismal process (GO:0051241) 2.843GATA6, FOXP1, GJA1
chordate embryonic development (GO:0043009) 4.383GATA6, FOXP1, GJA1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563GATA6, FOXP1, GATA4
regulation of heart growth (GO:0060420) 5.973GATA6, FOXP1, GJA1
tube morphogenesis (GO:0035239) 4.353GATA6, GATA4, GJA1
cardiac muscle cell differentiation (GO:0055007) 6.293GATA6, FOXP1, GATA4
cellular aromatic compound metabolic process (GO:0006725) 1.33GATA6, FOXP1, GATA4
regulation of nucleic acid-templated transcription (GO:1903506) 1.553GATA6, FOXP1, GATA4
positive regulation of transcription, DNA-templated (GO:0045893) 2.563GATA6, FOXP1, GATA4
regulation of localization (GO:0032879) 1.943FOXP1, GATA4, GJA1
regulation of RNA metabolic process (GO:0051252) 1.523GATA6, FOXP1, GATA4
positive regulation of RNA metabolic process (GO:0051254) 2.513GATA6, FOXP1, GATA4
macromolecule metabolic process (GO:0043170) 0.833GATA6, FOXP1, GATA4
positive regulation of RNA biosynthetic process (GO:1902680) 2.543GATA6, FOXP1, GATA4
regulation of cytokine production (GO:0001817) 3.43GATA6, FOXP1, GATA4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813GATA6, FOXP1, GATA4
positive regulation of cellular biosynthetic process (GO:0031328) 2.33GATA6, FOXP1, GATA4
negative regulation of cellular biosynthetic process (GO:0031327) 2.493GATA6, FOXP1, GJA1
positive regulation of cellular metabolic process (GO:0031325) 1.813GATA6, FOXP1, GATA4
negative regulation of cellular metabolic process (GO:0031324) 2.013GATA6, FOXP1, GJA1
nucleic acid metabolic process (GO:0090304) 1.463GATA6, FOXP1, GATA4
striated muscle cell differentiation (GO:0051146) 5.693GATA6, FOXP1, GATA4
multicellular organism development (GO:0007275) 2.543GATA6, FOXP1, GJA1
regulation of growth (GO:0040008) 3.263GATA6, FOXP1, GJA1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63GATA6, FOXP1, GJA1
organic substance metabolic process (GO:0071704) 0.633GATA6, FOXP1, GATA4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353GATA6, FOXP1, GATA4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553GATA6, FOXP1, GJA1
regulation of organ growth (GO:0046620) 5.413GATA6, FOXP1, GJA1
cardiocyte differentiation (GO:0035051) 6.023GATA6, FOXP1, GATA4
biosynthetic process (GO:0009058) 1.323GATA6, FOXP1, GATA4
macromolecule biosynthetic process (GO:0009059) 1.613GATA6, FOXP1, GATA4
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473GATA6, FOXP1, GJA1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293GATA6, FOXP1, GATA4
response to oxygen-containing compound (GO:1901700) 2.573FOXP1, GATA4, GJA1
primary metabolic process (GO:0044238) 0.693GATA6, FOXP1, GATA4
cellular metabolic process (GO:0044237) 0.693GATA6, FOXP1, GATA4
hemostasis (GO:0007599) 4.52GATA6, GATA4
regulation of secretion (GO:0051046) 3.22FOXP1, GJA1
regulation of transport (GO:0051049) 2.242FOXP1, GJA1
positive regulation of stem cell differentiation (GO:2000738) 7.022GATA6, GATA4
blood coagulation (GO:0007596) 4.522GATA6, GATA4
male gonad development (GO:0008584) 5.082GATA6, GATA4
muscle system process (GO:0003012) 4.182GATA6, GJA1
regulation of stem cell differentiation (GO:2000736) 6.262GATA6, GATA4
lung secretory cell differentiation (GO:0061140) 7.432GATA6, FOXP1
regulation of cardioblast differentiation (GO:0051890) 7.782GATA6, GATA4
regulation of defense response (GO:0031347) 3.112FOXP1, GJA1
developmental growth (GO:0048589) 4.052GATA4, GJA1
cellular response to organic substance (GO:0071310) 2.782GATA6, GATA4
response to mechanical stimulus (GO:0009612) 4.412GATA4, GJA1
regulation of BMP signaling pathway (GO:0030510) 5.362GATA6, GATA4
negative regulation of response to stimulus (GO:0048585) 2.522FOXP1, GJA1
columnar/cuboidal epithelial cell differentiation (GO:0002065) 5.842GATA6, GATA4
cellular homeostasis (GO:0019725) 3.232GATA4, GJA1
negative regulation of cell death (GO:0060548) 2.952GATA6, FOXP1
developmental process involved in reproduction (GO:0003006) 3.362GATA6, GATA4
positive regulation of BMP signaling pathway (GO:0030513) 6.262GATA6, GATA4
system process (GO:0003008) 2.32GATA6, GJA1
single organism signaling (GO:0044700) 3.252GATA4, GJA1
single organism reproductive process (GO:0044702) 2.732GATA6, GATA4
response to monosaccharide (GO:0034284) 4.772GATA4, GJA1
chemical homeostasis (GO:0048878) 2.972GATA4, GJA1
cardiac septum morphogenesis (GO:0060411) 5.92GATA6, GATA4
intestinal epithelial cell differentiation (GO:0060575) 7.942GATA6, GATA4
movement of cell or subcellular component (GO:0006928) 2.612FOXP1, GJA1
regulation of vasculature development (GO:1901342) 4.262GATA6, GATA4
regulation of protein transport (GO:0051223) 3.122FOXP1, GJA1
regulation of apoptotic process (GO:0042981) 2.52GATA6, FOXP1
positive regulation of cardioblast differentiation (GO:0051891) 8.122GATA6, GATA4
regulation of protein secretion (GO:0050708) 3.772FOXP1, GJA1
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122GATA6, GATA4
gonad development (GO:0008406) 4.922GATA6, GATA4
cellular component organization (GO:0016043) 1.242FOXP1, GJA1
cellular component organization or biogenesis (GO:0071840) 1.222FOXP1, GJA1
transcription from RNA polymerase II promoter (GO:0006366) 3.382GATA6, GATA4
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012GATA6, GATA4
regulation of establishment of protein localization (GO:0070201) 3.022FOXP1, GJA1
positive regulation of cardiac muscle tissue development (GO:0055025) 6.332GATA6, FOXP1
regulation of heart contraction (GO:0008016) 4.352GATA4, GJA1
transport (GO:0006810) 1.512FOXP1, GJA1
response to stress (GO:0006950) 1.82GATA6, GJA1
coagulation (GO:0050817) 4.512GATA6, GATA4
regulation of blood circulation (GO:1903522) 4.052GATA4, GJA1
establishment of localization (GO:0051234) 1.482FOXP1, GJA1
cell fate commitment (GO:0045165) 4.722GATA6, GATA4
regulation of response to stress (GO:0080134) 2.532FOXP1, GJA1
lung cell differentiation (GO:0060479) 6.472GATA6, FOXP1
regulation of response to external stimulus (GO:0032101) 3.062FOXP1, GJA1
signaling (GO:0023052) 3.252GATA4, GJA1
regulation of secretion by cell (GO:1903530) 3.282FOXP1, GJA1
cellular response to chemical stimulus (GO:0070887) 2.572GATA6, GATA4
mesenchyme development (GO:0060485) 5.72CRELD1, GATA4
regulation of protein localization (GO:0032880) 2.882FOXP1, GJA1
response to endogenous stimulus (GO:0009719) 2.792GATA6, GJA1
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292GATA6, GATA4
positive regulation of vasculature development (GO:1904018) 4.832GATA6, GATA4
regulation of system process (GO:0044057) 3.532GATA4, GJA1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122GATA6, FOXP1
heart looping (GO:0001947) 5.652GATA4, GJA1
endocardial cushion development (GO:0003197) 7.332CRELD1, GATA4
epithelial tube morphogenesis (GO:0060562) 5.122GATA4, GJA1
positive regulation of cell proliferation (GO:0008284) 3.012GATA6, FOXP1
reproductive structure development (GO:0048608) 4.082GATA6, GATA4
regulation of body fluid levels (GO:0050878) 3.762GATA6, GATA4
heart development (GO:0007507) 4.242FOXP1, GJA1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712GATA6, FOXP1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752GATA6, FOXP1
cellular chemical homeostasis (GO:0055082) 3.42GATA4, GJA1
cardiac septum development (GO:0003279) 5.942CRELD1, GATA4
negative regulation of developmental process (GO:0051093) 3.172FOXP1, GJA1
regulation of epithelial cell proliferation (GO:0050678) 4.062FOXP1, GJA1
response to hormone (GO:0009725) 3.332GATA6, GJA1
negative regulation of RNA metabolic process (GO:0051253) 2.662GATA6, FOXP1
response to drug (GO:0042493) 3.712GATA6, GATA4
homeostatic process (GO:0042592) 2.612GATA4, GJA1
striated muscle tissue development (GO:0014706) 5.232GATA6, FOXP1
regulation of cell death (GO:0010941) 2.432GATA6, FOXP1
morphogenesis of an epithelium (GO:0002009) 4.082GATA4, GJA1
growth (GO:0040007) 3.82GATA4, GJA1
response to lipid (GO:0033993) 3.112FOXP1, GATA4
regulation of angiogenesis (GO:0045765) 4.362GATA6, GATA4
positive regulation of angiogenesis (GO:0045766) 4.932GATA6, GATA4
regulation of programmed cell death (GO:0043067) 2.492GATA6, FOXP1
negative regulation of apoptotic process (GO:0043066) 3.042GATA6, FOXP1
tissue morphogenesis (GO:0048729) 3.872GATA4, GJA1
organic substance transport (GO:0071702) 2.152FOXP1, GJA1
negative regulation of programmed cell death (GO:0043069) 3.022GATA6, FOXP1
embryonic morphogenesis (GO:0048598) 3.722GATA4, GJA1
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392GATA6, GATA4
negative regulation of RNA biosynthetic process (GO:1902679) 2.72GATA6, FOXP1
reproductive process (GO:0022414) 2.552GATA6, GATA4
single-organism transport (GO:0044765) 2.182FOXP1, GJA1
cell-cell signaling (GO:0007267) 3.352GATA4, GJA1
cell communication (GO:0007154) 3.042GATA4, GJA1
lung epithelial cell differentiation (GO:0060487) 6.512GATA6, FOXP1
localization (GO:0051179) 1.42FOXP1, GJA1
single-organism localization (GO:1902578) 2.092FOXP1, GJA1
response to hexose (GO:0009746) 4.822GATA4, GJA1
embryonic heart tube morphogenesis (GO:0003143) 5.572GATA4, GJA1
regulation of cellular component movement (GO:0051270) 3.082FOXP1, GATA4
response to carbohydrate (GO:0009743) 4.622GATA4, GJA1
response to glucose (GO:0009749) 4.862GATA4, GJA1
muscle tissue development (GO:0060537) 5.12GATA6, FOXP1

NET-GE enrichment

Term New enriched termICP valueGenes
intestinal epithelial cell differentiation (GO:0060575) -7.940.002GATA6, GATA4
regulation of developmental growth (GO:0048638) -4.040.0GATA6, FOXP1, GATA4, GJA1
embryo development (GO:0009790) -4.20.043GATA6, FOXP1, GATA4, GJA1
in utero embryonic development (GO:0001701) -4.40.015GATA6, FOXP1, GATA4, GJA1
positive regulation of stem cell differentiation (GO:2000738) -7.020.032GATA6, GATA4
pancreatic A cell differentiation (GO:0003310) NEW8.630.001GATA6, GATA4
regulation of muscle organ development (GO:0048634) -5.070.0GATA6, FOXP1, GATA4, GJA1
actin cytoskeleton organization (GO:0030036) NEW4.10.019GATA6, FOXP1, GATA4, GJA1
negative regulation of cardiac muscle cell proliferation (GO:0060044) NEW7.530.01GATA4, GJA1
positive regulation of cardiac muscle cell proliferation (GO:0060045) NEW6.780.0GATA6, GATA4, GJA1
striated muscle tissue development (GO:0014706) -5.230.0GATA6, FOXP1, GATA4, GJA1
embryo development ending in birth or egg hatching (GO:0009792) -4.350.018GATA6, FOXP1, GATA4, GJA1
striated muscle cell differentiation (GO:0051146) -5.690.008GATA6, FOXP1, GATA4
lung secretory cell differentiation (GO:0061140) -7.430.037GATA6, FOXP1
regulation of cardioblast differentiation (GO:0051890) -7.780.001GATA6, GATA4
positive regulation of cardioblast differentiation (GO:0051891) -8.120.0GATA6, GATA4
muscle adaptation (GO:0043500) NEW6.430.014GATA6, GATA4
outflow tract morphogenesis (GO:0003151) NEW5.970.004GATA6, GATA4, GJA1
cellular response to gonadotropin stimulus (GO:0071371) NEW7.020.005GATA6, GATA4
regulation of male gonad development (GO:2000018) NEW7.530.02GATA6, GATA4
regulation of growth (GO:0040008) -3.260.002GATA6, FOXP1, GATA4, GJA1
muscle hypertrophy in response to stress (GO:0003299) NEW7.330.003GATA6, GATA4
cardiac muscle adaptation (GO:0014887) NEW7.330.003GATA6, GATA4
negative regulation of cellular response to growth factor stimulus (GO:0090288) NEW4.920.047GATA6, GATA4, GJA1
endocardial cushion development (GO:0003197) -7.330.001CRELD1, GATA4
epithelial cell differentiation (GO:0030855) -3.980.023GATA6, FOXP1, GATA4
response to gonadotropin (GO:0034698) NEW6.40.011GATA6, GATA4
chordate embryonic development (GO:0043009) -4.380.016GATA6, FOXP1, GATA4, GJA1
cardiac muscle hypertrophy (GO:0003300) NEW6.840.005GATA6, GATA4
columnar/cuboidal epithelial cell differentiation (GO:0002065) -5.840.044GATA6, GATA4
regulation of muscle tissue development (GO:1901861) -5.070.001GATA6, FOXP1, GATA4, GJA1
regulation of striated muscle tissue development (GO:0016202) -5.090.001GATA6, FOXP1, GATA4, GJA1
regulation of heart growth (GO:0060420) -5.970.0GATA6, FOXP1, GATA4, GJA1
tube morphogenesis (GO:0035239) -4.350.001GATA6, GATA4, GJA1
actin filament-based process (GO:0030029) NEW3.940.033GATA6, FOXP1, GATA4, GJA1
cardiac muscle cell differentiation (GO:0055007) -6.290.001GATA6, FOXP1, GATA4
regulation of organ growth (GO:0046620) -5.410.0GATA6, FOXP1, GATA4, GJA1
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) NEW5.130.033GATA6, GATA4, GJA1
regulation of cardiac muscle tissue development (GO:0055024) -5.860.0GATA6, FOXP1, GATA4, GJA1
cardiocyte differentiation (GO:0035051) -6.020.004GATA6, FOXP1, GATA4
tissue development (GO:0009888) -3.270.043CRELD1, GATA6, FOXP1, GATA4, GJA1
anatomical structure regression (GO:0060033) NEW7.240.037GATA6, GATA4
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.0GATA6, FOXP1, GATA4, GJA1
striated muscle adaptation (GO:0014888) NEW6.680.01GATA6, GATA4
mesenchyme development (GO:0060485) -5.70.006GATA6, CRELD1, GATA4
lung epithelial cell differentiation (GO:0060487) -6.510.013GATA6, FOXP1
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.0GATA6, FOXP1, GATA4, GJA1
cardiac right ventricle morphogenesis (GO:0003215) NEW7.430.021GATA6, GATA4
cardiac septum development (GO:0003279) -5.940.01CRELD1, GATA4
positive regulation of developmental process (GO:0051094) -2.770.011GATA6, FOXP1, GATA4, GJA1
anatomical structure development (GO:0048856) -1.580.035CRELD1, GATA6, FOXP1, GATA4, GJA1
muscle system process (GO:0003012) -4.180.011GATA6, GATA4, GJA1
muscle hypertrophy (GO:0014896) NEW6.680.007GATA6, GATA4
striated muscle hypertrophy (GO:0014897) NEW6.780.006GATA6, GATA4
lung cell differentiation (GO:0060479) -6.470.014GATA6, FOXP1
muscle tissue development (GO:0060537) -5.10.001GATA6, FOXP1, GATA4, GJA1
cardiac septum morphogenesis (GO:0060411) -5.90.03GATA6, GATA4
cardiac muscle hypertrophy in response to stress (GO:0014898) NEW7.330.003GATA6, GATA4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.64GATA6, FOXP1, GATA4, GJA1
cell part (GO:0044464) 0.114GATA6, FOXP1, GATA4, GJA1
intracellular organelle part (GO:0044446) 0.814GATA6, FOXP1, GATA4, GJA1
intracellular organelle (GO:0043229) 0.514GATA6, FOXP1, GATA4, GJA1
intracellular part (GO:0044424) 0.284GATA6, FOXP1, GATA4, GJA1
membrane-bounded organelle (GO:0043227) 0.474GATA6, FOXP1, GATA4, GJA1
organelle (GO:0043226) 0.44GATA6, FOXP1, GATA4, GJA1
organelle part (GO:0044422) 0.794GATA6, FOXP1, GATA4, GJA1
nucleoplasm (GO:0005654) 1.893GATA6, FOXP1, GATA4
protein complex (GO:0043234) 1.513GATA6, GATA4, GJA1
nucleus (GO:0005634) 1.073GATA6, FOXP1, GATA4
nuclear part (GO:0044428) 1.553GATA6, FOXP1, GATA4
macromolecular complex (GO:0032991) 1.353GATA6, GATA4, GJA1
membrane part (GO:0044425) 0.952CRELD1, GJA1
integral component of membrane (GO:0016021) 1.142CRELD1, GJA1
membrane (GO:0016020) 0.682CRELD1, GJA1
transcription factor complex (GO:0005667) 4.12GATA6, GATA4
intrinsic component of membrane (GO:0031224) 1.132CRELD1, GJA1

NET-GE enrichment

Term New enriched termICP valueGenes
intercalated disc (GO:0014704) NEW5.930.019GATA4, GJA1
cell-cell contact zone (GO:0044291) NEW5.690.033GATA4, GJA1
endoplasmic reticulum lumen (GO:0005788) NEW4.50.011GATA6, GATA4, GJA1
transcription factor complex (GO:0005667) -4.10.045GATA6, GATA4, GJA1