Disease table of VENTRICULAR SEPTAL DEFECT OMIM ID: PS614429

Gene-disease associations table

GeneAssociated with VENTRICULAR SEPTAL DEFECT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CITED2OMIMHGNC link6q24.12PS108800, PS614429
GATA4ClinVar, OMIM, HUMSAVARHGNC link8p23.15PS614429, PS108800, 615542, PS606215, 187500
NKX2-5ClinVar, OMIM, HUMSAVARHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
CITED2YES3MMP1, MMP13, HIF1A0
GATA4YES22NKX2-5, FGF10, HDAC9, CYP17A1, NOS3, CCND2, BMP4, HESX1, HAMP, FCGR3B, STAR, ERBB2, FABP2, IAPP, NPPA, AMH, SUMO1, NPPB, IL5, SGPL1, FCGR2B, MEF2C1NKX2-5
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL11GATA4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CITED2YES2HDAC9, NR5A10
GATA4YES4HEY2, HEY1, NKX2-5, NANOG1NKX2-5
NKX2-5YES1GATA41GATA4
NPPBNO7XBP1, NKX2-5, GATA4, TEF, SHOX, RELA, NFKB12NKX2-5, GATA4
MEF2CNO5NKX2-5, GFI1B, GATA4, ISL1, HDAC72NKX2-5, GATA4
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CITED2GATA4No2MAPK1, EP300
GATA4NKX2-5Yes7JARID2, FOXE1, ID3, TBX5, ID2, KDM6A, ID1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CITED2GATA4No-3WT1, EPO, EP300
GATA4NKX2-5Yesactivation, binding29BMPR1A, BMP4, SMAD4, ATF2, BMP7, BMP5, SRF, SUMO1, SMAD6, MAP3K7, SMAD3, HAND2, SMARCD3, SMAD5, CHRD, BMPR2, MEF2A, SMAD2, ID2, NFATC1, NOG, JARID2, BCL2, MYL2, TBX5, BMP10, MYOCD, BMP2, MEF2C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
GATA4NKX2-5yes, they interact but maybe not in complexGATA4 acts as a transcriptional activator of ANF in cooperation with NKX2-5. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Generic Transcription PathwayR-HSA-2124363.862NKX2-5, GATA4
Gene ExpressionR-HSA-741602.722NKX2-5, GATA4
YAP1- and WWTR1 (TAZ)-stimulated gene expressionR-HSA-20327858.122NKX2-5, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
Generic Transcription Pathway (R-HSA-212436) -3.860.047NKX2-5, GATA4
YAP1- and WWTR1 (TAZ)-stimulated gene expression (R-HSA-2032785) -8.120.005NKX2-5, GATA4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein binding (GO:0005515) 0.463CITED2, NKX2-5, GATA4
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653CITED2, NKX2-5, GATA4
transcription factor binding (GO:0008134) 3.463CITED2, NKX2-5, GATA4
transcription cofactor activity (GO:0003712) 3.443CITED2, NKX2-5, GATA4
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076) 4.843CITED2, NKX2-5, GATA4
macromolecular complex binding (GO:0044877) 2.613CITED2, NKX2-5, GATA4
binding (GO:0005488) 0.183CITED2, NKX2-5, GATA4
transcription factor activity, transcription factor binding (GO:0000989) 3.363CITED2, NKX2-5, GATA4
transcription factor activity, protein binding (GO:0000988) 3.353CITED2, NKX2-5, GATA4
chromatin binding (GO:0003682) 3.643CITED2, NKX2-5, GATA4
nucleic acid binding transcription factor activity (GO:0001071) 2.653CITED2, NKX2-5, GATA4
activating transcription factor binding (GO:0033613) 5.682CITED2, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362NKX2-5, GATA4
enzyme binding (GO:0019899) 2.272CITED2, GATA4
nucleic acid binding (GO:0003676) 1.442NKX2-5, GATA4
DNA binding (GO:0003677) 1.922NKX2-5, GATA4
heterocyclic compound binding (GO:1901363) 1.062NKX2-5, GATA4
RNA polymerase II transcription cofactor activity (GO:0001104) 5.222CITED2, NKX2-5
sequence-specific DNA binding (GO:0043565) 2.792NKX2-5, GATA4
transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) 5.282CITED2, NKX2-5
sequence-specific double-stranded DNA binding (GO:1990837) 3.22NKX2-5, GATA4
transcription coactivator activity (GO:0003713) 4.042CITED2, GATA4
double-stranded DNA binding (GO:0003690) 3.092NKX2-5, GATA4
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292NKX2-5, GATA4
regulatory region DNA binding (GO:0000975) 3.032NKX2-5, GATA4
regulatory region nucleic acid binding (GO:0001067) 3.032NKX2-5, GATA4
SMAD binding (GO:0046332) 5.452CITED2, GATA4
transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190) 5.772CITED2, NKX2-5
RNA polymerase II transcription factor binding (GO:0001085) 5.082CITED2, GATA4
transcription regulatory region DNA binding (GO:0044212) 3.032NKX2-5, GATA4
transcriptional repressor activity, RNA polymerase II activating transcription factor binding (GO:0098811) 5.772CITED2, NKX2-5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982NKX2-5, GATA4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242NKX2-5, GATA4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372NKX2-5, GATA4
organic cyclic compound binding (GO:0097159) 1.052NKX2-5, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
activating transcription factor binding (GO:0033613) -5.680.001CITED2, NKX2-5, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.04NKX2-5, GATA4
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.035NKX2-5, GATA4
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) -4.840.0CITED2, NKX2-5, GATA4
nucleic acid binding transcription factor activity (GO:0001071) -2.650.014CITED2, NKX2-5, GATA4
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (GO:0001191) -5.280.008CITED2, GATA4
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190) -5.770.01CITED2, NKX2-5
transcription corepressor activity (GO:0003714) NEW4.330.006CITED2, NKX2-5, GATA4
transcription coactivator activity (GO:0003713) -4.040.044CITED2, NKX2-5, GATA4
transcription cofactor activity (GO:0003712) -3.440.001CITED2, NKX2-5, GATA4
transcription factor binding transcription factor activity (GO:0000989) -3.360.002CITED2, NKX2-5, GATA4
protein binding transcription factor activity (GO:0000988) -3.350.002CITED2, NKX2-5, GATA4
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.034CITED2, NKX2-5, GATA4
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) NEW5.580.018NKX2-5, GATA4
transcription factor binding (GO:0008134) -3.460.001CITED2, NKX2-5, GATA4
SMAD binding (GO:0046332) -5.450.0CITED2, NKX2-5, GATA4
RNA polymerase II transcription coactivator activity (GO:0001105) NEW6.150.003CITED2, NKX2-5
RNA polymerase II transcription corepressor activity (GO:0001106) NEW6.480.004CITED2, GATA4
RNA polymerase II activating transcription factor binding (GO:0001102) NEW6.130.008CITED2, NKX2-5
RNA polymerase II transcription factor binding (GO:0001085) -5.080.0CITED2, NKX2-5, GATA4
RNA polymerase II transcription cofactor activity (GO:0001104) -5.220.003CITED2, NKX2-5, GATA4
sequence-specific DNA binding transcription factor activity (GO:0003700) -2.650.014CITED2, NKX2-5, GATA4
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) NEW5.230.004NKX2-5, GATA4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.038NKX2-5, GATA4
chromatin binding (GO:0003682) -3.640.034CITED2, NKX2-5, GATA4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.083CITED2, NKX2-5, GATA4
regulation of metabolic process (GO:0019222) 1.023CITED2, NKX2-5, GATA4
cell development (GO:0048468) 3.283CITED2, NKX2-5, GATA4
organic cyclic compound biosynthetic process (GO:1901362) 1.663CITED2, NKX2-5, GATA4
organic cyclic compound metabolic process (GO:1901360) 1.263CITED2, NKX2-5, GATA4
morphogenesis of an epithelium (GO:0002009) 4.083CITED2, NKX2-5, GATA4
positive regulation of macromolecule metabolic process (GO:0010604) 1.813CITED2, NKX2-5, GATA4
regulation of signal transduction (GO:0009966) 1.843CITED2, NKX2-5, GATA4
cellular developmental process (GO:0048869) 1.823CITED2, NKX2-5, GATA4
animal organ development (GO:0048513) 2.533CITED2, NKX2-5, GATA4
positive regulation of biological process (GO:0048518) 1.23CITED2, NKX2-5, GATA4
negative regulation of biological process (GO:0048519) 1.333CITED2, NKX2-5, GATA4
regulation of macromolecule metabolic process (GO:0060255) 1.083CITED2, NKX2-5, GATA4
regulation of response to stimulus (GO:0048583) 1.543CITED2, NKX2-5, GATA4
regionalization (GO:0003002) 4.243CITED2, NKX2-5, GATA4
regulation of RNA biosynthetic process (GO:2001141) 1.553CITED2, NKX2-5, GATA4
heterocycle metabolic process (GO:0046483) 1.313CITED2, NKX2-5, GATA4
single-multicellular organism process (GO:0044707) 1.783CITED2, NKX2-5, GATA4
aromatic compound biosynthetic process (GO:0019438) 1.73CITED2, NKX2-5, GATA4
cardiac septum morphogenesis (GO:0060411) 5.93CITED2, NKX2-5, GATA4
positive regulation of metabolic process (GO:0009893) 1.743CITED2, NKX2-5, GATA4
positive regulation of biosynthetic process (GO:0009891) 2.293CITED2, NKX2-5, GATA4
nitrogen compound metabolic process (GO:0006807) 1.133CITED2, NKX2-5, GATA4
regulation of biological process (GO:0050789) 0.453CITED2, NKX2-5, GATA4
nucleic acid-templated transcription (GO:0097659) 1.913CITED2, NKX2-5, GATA4
positive regulation of RNA biosynthetic process (GO:1902680) 2.543CITED2, NKX2-5, GATA4
regulation of cell communication (GO:0010646) 1.733CITED2, NKX2-5, GATA4
cellular macromolecule metabolic process (GO:0044260) 0.933CITED2, NKX2-5, GATA4
biological regulation (GO:0065007) 0.393CITED2, NKX2-5, GATA4
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013CITED2, NKX2-5, GATA4
heterocycle biosynthetic process (GO:0018130) 1.73CITED2, NKX2-5, GATA4
regulation of developmental process (GO:0050793) 2.13CITED2, NKX2-5, GATA4
regulation of biosynthetic process (GO:0009889) 1.373CITED2, NKX2-5, GATA4
tissue development (GO:0009888) 3.273CITED2, NKX2-5, GATA4
regulation of cellular process (GO:0050794) 0.53CITED2, NKX2-5, GATA4
metabolic process (GO:0008152) 0.583CITED2, NKX2-5, GATA4
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723CITED2, NKX2-5, GATA4
RNA metabolic process (GO:0016070) 1.593CITED2, NKX2-5, GATA4
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593CITED2, NKX2-5, GATA4
regulation of transcription, DNA-templated (GO:0006355) 1.563CITED2, NKX2-5, GATA4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393CITED2, NKX2-5, GATA4
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243CITED2, NKX2-5, GATA4
transcription, DNA-templated (GO:0006351) 1.913CITED2, NKX2-5, GATA4
RNA biosynthetic process (GO:0032774) 1.843CITED2, NKX2-5, GATA4
cell differentiation (GO:0030154) 2.143CITED2, NKX2-5, GATA4
cellular biosynthetic process (GO:0044249) 1.373CITED2, NKX2-5, GATA4
cellular nitrogen compound metabolic process (GO:0034641) 1.223CITED2, NKX2-5, GATA4
cellular macromolecule biosynthetic process (GO:0034645) 1.663CITED2, NKX2-5, GATA4
regulation of signaling (GO:0023051) 1.723CITED2, NKX2-5, GATA4
anatomical structure morphogenesis (GO:0009653) 2.533CITED2, NKX2-5, GATA4
single-organism process (GO:0044699) 0.483CITED2, NKX2-5, GATA4
nucleobase-containing compound metabolic process (GO:0006139) 1.353CITED2, NKX2-5, GATA4
positive regulation of multicellular organismal process (GO:0051240) 2.493CITED2, NKX2-5, GATA4
heart looping (GO:0001947) 5.653CITED2, NKX2-5, GATA4
epithelial tube morphogenesis (GO:0060562) 5.123CITED2, NKX2-5, GATA4
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563CITED2, NKX2-5, GATA4
multicellular organismal process (GO:0032501) 1.453CITED2, NKX2-5, GATA4
tube morphogenesis (GO:0035239) 4.353CITED2, NKX2-5, GATA4
embryonic heart tube morphogenesis (GO:0003143) 5.573CITED2, NKX2-5, GATA4
cellular process (GO:0009987) 0.263CITED2, NKX2-5, GATA4
cellular aromatic compound metabolic process (GO:0006725) 1.33CITED2, NKX2-5, GATA4
regulation of nucleic acid-templated transcription (GO:1903506) 1.553CITED2, NKX2-5, GATA4
positive regulation of transcription, DNA-templated (GO:0045893) 2.563CITED2, NKX2-5, GATA4
regulation of localization (GO:0032879) 1.943CITED2, NKX2-5, GATA4
positive regulation of developmental process (GO:0051094) 2.773CITED2, NKX2-5, GATA4
regulation of RNA metabolic process (GO:0051252) 1.523CITED2, NKX2-5, GATA4
positive regulation of RNA metabolic process (GO:0051254) 2.513CITED2, NKX2-5, GATA4
macromolecule metabolic process (GO:0043170) 0.833CITED2, NKX2-5, GATA4
regulation of multicellular organismal process (GO:0051239) 1.873CITED2, NKX2-5, GATA4
positive regulation of gene expression (GO:0010628) 2.353CITED2, NKX2-5, GATA4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813CITED2, NKX2-5, GATA4
developmental process (GO:0032502) 1.363CITED2, NKX2-5, GATA4
positive regulation of cellular biosynthetic process (GO:0031328) 2.33CITED2, NKX2-5, GATA4
regulation of cellular biosynthetic process (GO:0031326) 1.383CITED2, NKX2-5, GATA4
positive regulation of cellular metabolic process (GO:0031325) 1.813CITED2, NKX2-5, GATA4
regulation of cellular metabolic process (GO:0031323) 1.073CITED2, NKX2-5, GATA4
nucleic acid metabolic process (GO:0090304) 1.463CITED2, NKX2-5, GATA4
pattern specification process (GO:0007389) 3.793CITED2, NKX2-5, GATA4
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463CITED2, NKX2-5, GATA4
organic substance metabolic process (GO:0071704) 0.633CITED2, NKX2-5, GATA4
regulation of macromolecule biosynthetic process (GO:0010556) 1.433CITED2, NKX2-5, GATA4
tissue morphogenesis (GO:0048729) 3.873CITED2, NKX2-5, GATA4
regulation of gene expression (GO:0010468) 1.373CITED2, NKX2-5, GATA4
embryonic morphogenesis (GO:0048598) 3.723CITED2, NKX2-5, GATA4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353CITED2, NKX2-5, GATA4
organic substance biosynthetic process (GO:1901576) 1.343CITED2, NKX2-5, GATA4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433CITED2, NKX2-5, GATA4
single-organism developmental process (GO:0044767) 1.493CITED2, NKX2-5, GATA4
biosynthetic process (GO:0009058) 1.323CITED2, NKX2-5, GATA4
macromolecule biosynthetic process (GO:0009059) 1.613CITED2, NKX2-5, GATA4
single-organism cellular process (GO:0044763) 0.653CITED2, NKX2-5, GATA4
regulation of nitrogen compound metabolic process (GO:0051171) 1.363CITED2, NKX2-5, GATA4
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293CITED2, NKX2-5, GATA4
mesenchyme development (GO:0060485) 5.73CITED2, NKX2-5, GATA4
primary metabolic process (GO:0044238) 0.693CITED2, NKX2-5, GATA4
cardiac septum development (GO:0003279) 5.943CITED2, NKX2-5, GATA4
anatomical structure development (GO:0048856) 1.583CITED2, NKX2-5, GATA4
cellular metabolic process (GO:0044237) 0.693CITED2, NKX2-5, GATA4
regulation of multicellular organismal development (GO:2000026) 2.313CITED2, NKX2-5, GATA4
negative regulation of cellular process (GO:0048523) 1.413CITED2, NKX2-5, GATA4
positive regulation of cellular process (GO:0048522) 1.33CITED2, NKX2-5, GATA4
response to abiotic stimulus (GO:0009628) 2.82CITED2, GATA4
regulation of stem cell differentiation (GO:2000736) 6.262NKX2-5, GATA4
positive regulation of stem cell differentiation (GO:2000738) 7.022NKX2-5, GATA4
positive regulation of response to stimulus (GO:0048584) 2.182CITED2, GATA4
male gonad development (GO:0008584) 5.082CITED2, GATA4
signal transduction (GO:0007165) 1.282CITED2, NKX2-5
cell surface receptor signaling pathway (GO:0007166) 2.092CITED2, NKX2-5
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242CITED2, NKX2-5
positive regulation of cardioblast differentiation (GO:0051891) 8.122NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) 7.782NKX2-5, GATA4
outflow tract morphogenesis (GO:0003151) 5.972CITED2, NKX2-5
cellular response to stimulus (GO:0051716) 1.972CITED2, GATA4
negative regulation of macromolecule metabolic process (GO:0010605) 2.012CITED2, NKX2-5
positive regulation of signal transduction (GO:0009967) 2.52CITED2, GATA4
cellular response to organic substance (GO:0071310) 2.782CITED2, GATA4
response to mechanical stimulus (GO:0009612) 4.412CITED2, GATA4
response to organic substance (GO:0010033) 2.22CITED2, GATA4
(GO:1905207) 6.42NKX2-5, GATA4
regulation of muscle contraction (GO:0006937) 4.752NKX2-5, GATA4
(GO:1905209) 6.732NKX2-5, GATA4
negative regulation of cell death (GO:0060548) 2.952CITED2, NKX2-5
developmental process involved in reproduction (GO:0003006) 3.362CITED2, GATA4
regulation of cardiac muscle contraction (GO:0055117) 5.572NKX2-5, GATA4
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62CITED2, NKX2-5
single organism reproductive process (GO:0044702) 2.732CITED2, GATA4
response to external stimulus (GO:0009605) 2.552CITED2, GATA4
atrial septum morphogenesis (GO:0060413) 7.092NKX2-5, GATA4
ventricular septum morphogenesis (GO:0060412) 6.592CITED2, NKX2-5
muscle cell differentiation (GO:0042692) 5.092NKX2-5, GATA4
negative regulation of metabolic process (GO:0009892) 1.932CITED2, NKX2-5
negative regulation of biosynthetic process (GO:0009890) 2.472CITED2, NKX2-5
regulation of anatomical structure morphogenesis (GO:0022603) 2.792CITED2, GATA4
ventricular septum development (GO:0003281) 6.362CITED2, GATA4
negative regulation of gene expression (GO:0010629) 2.482CITED2, NKX2-5
regulation of apoptotic process (GO:0042981) 2.52CITED2, NKX2-5
cardiac chamber morphogenesis (GO:0003206) 6.362NKX2-5, GATA4
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122CITED2, GATA4
gonad development (GO:0008406) 4.922CITED2, GATA4
cardiac ventricle morphogenesis (GO:0003208) 6.552NKX2-5, GATA4
transcription from RNA polymerase II promoter (GO:0006366) 3.382NKX2-5, GATA4
organ morphogenesis (GO:0009887) 3.552CITED2, NKX2-5
regulation of heart contraction (GO:0008016) 4.352NKX2-5, GATA4
regulation of blood circulation (GO:1903522) 4.052NKX2-5, GATA4
vasculogenesis (GO:0001570) 5.652CITED2, NKX2-5
cell fate commitment (GO:0045165) 4.722NKX2-5, GATA4
response to stimulus (GO:0050896) 1.222CITED2, GATA4
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532CITED2, NKX2-5
positive regulation of signaling (GO:0023056) 2.412CITED2, GATA4
regulation of striated muscle contraction (GO:0006942) 5.382NKX2-5, GATA4
cellular response to chemical stimulus (GO:0070887) 2.572CITED2, GATA4
positive regulation of cell communication (GO:0010647) 2.412CITED2, GATA4
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292CITED2, GATA4
regulation of system process (GO:0044057) 3.532NKX2-5, GATA4
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122CITED2, NKX2-5
endocardial cushion development (GO:0003197) 7.332CITED2, GATA4
reproductive structure development (GO:0048608) 4.082CITED2, GATA4
cell proliferation (GO:0008283) 3.232CITED2, NKX2-5
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712CITED2, NKX2-5
positive regulation of cell differentiation (GO:0045597) 3.012NKX2-5, GATA4
regulation of cell differentiation (GO:0045595) 2.422NKX2-5, GATA4
negative regulation of transcription, DNA-templated (GO:0045892) 2.752CITED2, NKX2-5
negative regulation of RNA metabolic process (GO:0051253) 2.662CITED2, NKX2-5
system development (GO:0048731) 2.922CITED2, NKX2-5
gland development (GO:0048732) 4.152CITED2, NKX2-5
negative regulation of cellular biosynthetic process (GO:0031327) 2.492CITED2, NKX2-5
negative regulation of cellular metabolic process (GO:0031324) 2.012CITED2, NKX2-5
embryonic heart tube left/right pattern formation (GO:0060971) 8.342CITED2, NKX2-5
left/right pattern formation (GO:0060972) 7.532CITED2, NKX2-5
striated muscle cell differentiation (GO:0051146) 5.692NKX2-5, GATA4
regulation of cell death (GO:0010941) 2.432CITED2, NKX2-5
multicellular organism development (GO:0007275) 2.542CITED2, NKX2-5
cardiac muscle cell differentiation (GO:0055007) 6.292NKX2-5, GATA4
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62CITED2, NKX2-5
regulation of programmed cell death (GO:0043067) 2.492CITED2, NKX2-5
negative regulation of apoptotic process (GO:0043066) 3.042CITED2, NKX2-5
spleen development (GO:0048536) 6.072CITED2, NKX2-5
hematopoietic or lymphoid organ development (GO:0048534) 4.492CITED2, NKX2-5
negative regulation of programmed cell death (GO:0043069) 3.022CITED2, NKX2-5
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392CITED2, GATA4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552CITED2, NKX2-5
cardiocyte differentiation (GO:0035051) 6.022NKX2-5, GATA4
negative regulation of RNA biosynthetic process (GO:1902679) 2.72CITED2, NKX2-5
reproductive process (GO:0022414) 2.552CITED2, GATA4
regulation of muscle system process (GO:0090257) 4.512NKX2-5, GATA4
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472CITED2, NKX2-5
response to chemical (GO:0042221) 1.982CITED2, GATA4
heart development (GO:0007507) 4.242CITED2, NKX2-5
regulation of cellular component movement (GO:0051270) 3.082CITED2, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
heart trabecula formation (GO:0060347) NEW7.090.014NKX2-5, GATA4
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) NEW6.590.012NKX2-5, GATA4
ventricular cardiac muscle cell development (GO:0055015) NEW7.330.005NKX2-5, GATA4
vasculogenesis (GO:0001570) -5.650.001CITED2, NKX2-5, GATA4
regulation of stem cell differentiation (GO:2000736) -6.260.038NKX2-5, GATA4
positive regulation of stem cell differentiation (GO:2000738) -7.020.007NKX2-5, GATA4
regulation of cardiac muscle cell proliferation (GO:0060043) NEW6.330.005NKX2-5, GATA4
regulation of heart growth (GO:0060420) NEW5.970.008NKX2-5, GATA4
atrial septum development (GO:0003283) NEW7.780.001NKX2-5, GATA4
male gonad development (GO:0008584) -5.080.03CITED2, GATA4
negative regulation of cardiac muscle cell apoptotic process (GO:0010667) NEW7.160.002NKX2-5, GATA4
BMP signaling pathway (GO:0030509) NEW5.330.021NKX2-5, GATA4
striated muscle tissue development (GO:0014706) NEW5.230.033NKX2-5, GATA4
regulation of striated muscle contraction (GO:0006942) -5.380.013NKX2-5, GATA4
regulation of striated muscle cell apoptotic process (GO:0010662) NEW6.640.01NKX2-5, GATA4
embryonic axis specification (GO:0000578) NEW6.360.043NKX2-5, GATA4
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.036CITED2, NKX2-5, GATA4
axis specification (GO:0009798) NEW5.420.002CITED2, NKX2-5, GATA4
positive regulation of cardioblast differentiation (GO:0051891) -8.120.0NKX2-5, GATA4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.028CITED2, NKX2-5, GATA4
ventricular trabecula myocardium morphogenesis (GO:0003222) NEW7.330.004NKX2-5, GATA4
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) NEW9.040.0NKX2-5, GATA4
outflow tract morphogenesis (GO:0003151) -5.970.0CITED2, NKX2-5, GATA4
pattern specification process (GO:0007389) -3.790.005CITED2, NKX2-5, GATA4
regulation of cellular response to growth factor stimulus (GO:0090287) -4.290.022CITED2, NKX2-5, GATA4
regulation of male gonad development (GO:2000018) NEW7.530.005CITED2, GATA4
stem cell development (GO:0048864) NEW7.940.03CITED2, GATA4
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) -5.120.025CITED2, GATA4
adult heart development (GO:0007512) NEW7.160.015NKX2-5, GATA4
heart looping (GO:0001947) -5.650.001CITED2, NKX2-5, GATA4
endocardial cushion development (GO:0003197) -7.330.003CITED2, GATA4
regulation of cardiac muscle cell apoptotic process (GO:0010665) NEW6.780.007NKX2-5, GATA4
blood vessel morphogenesis (GO:0048514) NEW5.320.003CITED2, NKX2-5, GATA4
tissue morphogenesis (GO:0048729) -3.870.004CITED2, NKX2-5, GATA4
spleen development (GO:0048536) -6.070.005CITED2, NKX2-5, GATA4
epithelial tube morphogenesis (GO:0060562) -5.120.005CITED2, NKX2-5, GATA4
hematopoietic or lymphoid organ development (GO:0048534) -4.490.037CITED2, NKX2-5, GATA4
negative regulation of muscle cell apoptotic process (GO:0010656) NEW6.330.025NKX2-5, GATA4
response to transforming growth factor beta (GO:0071559) NEW5.620.016CITED2, NKX2-5, GATA4
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.031CITED2, NKX2-5, GATA4
tissue development (GO:0009888) -3.270.021CITED2, NKX2-5, GATA4
embryonic morphogenesis (GO:0048598) -3.720.006CITED2, NKX2-5, GATA4
negative regulation of cell migration (GO:0030336) NEW4.410.036CITED2, NKX2-5, GATA4
organ morphogenesis (GO:0009887) -3.550.006CITED2, NKX2-5, GATA4
tube morphogenesis (GO:0035239) -4.350.008CITED2, NKX2-5, GATA4
morphogenesis of an epithelium (GO:0002009) -4.080.002CITED2, NKX2-5, GATA4
regulation of organ growth (GO:0046620) NEW5.410.026NKX2-5, GATA4
embryonic heart tube anterior/posterior pattern specification (GO:0035054) NEW8.630.0NKX2-5, GATA4
regulation of cardiac muscle tissue development (GO:0055024) NEW5.860.012NKX2-5, GATA4
negative regulation of cell motility (GO:2000146) NEW4.360.038CITED2, NKX2-5, GATA4
cardiac chamber formation (GO:0003207) NEW7.330.005NKX2-5, GATA4
regulation of cardiac muscle tissue growth (GO:0055021) NEW6.120.006NKX2-5, GATA4
canonical Wnt signaling pathway (GO:0060070) NEW5.260.033NKX2-5, GATA4
mesenchymal cell development (GO:0014031) NEW6.550.019CITED2, GATA4
regionalization (GO:0003002) -4.240.001CITED2, NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) -7.780.003NKX2-5, GATA4
heart development (GO:0007507) -4.240.03CITED2, NKX2-5, GATA4
mesenchyme development (GO:0060485) -5.70.0CITED2, NKX2-5, GATA4
negative regulation of striated muscle cell apoptotic process (GO:0010664) NEW6.90.004NKX2-5, GATA4
regulation of cardiac muscle contraction (GO:0055117) -5.570.008NKX2-5, GATA4
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) -4.60.001CITED2, NKX2-5, GATA4
embryonic heart tube morphogenesis (GO:0003143) -5.570.001CITED2, NKX2-5, GATA4
negative regulation of cellular component movement (GO:0051271) NEW4.220.042CITED2, NKX2-5, GATA4
embryonic organ morphogenesis (GO:0048562) NEW4.920.013CITED2, NKX2-5, GATA4
cardiac septum development (GO:0003279) -5.940.003NKX2-5, GATA4
embryonic heart tube left/right pattern formation (GO:0060971) -8.340.0CITED2, NKX2-5
cardiac ventricle formation (GO:0003211) NEW7.430.004NKX2-5, GATA4
positive regulation of developmental process (GO:0051094) -2.770.048CITED2, NKX2-5, GATA4
left/right pattern formation (GO:0060972) -7.530.006CITED2, NKX2-5
cardiac muscle tissue development (GO:0048738) NEW6.330.003NKX2-5, GATA4
cellular response to transforming growth factor beta stimulus (GO:0071560) NEW5.740.016CITED2, NKX2-5, GATA4
positive regulation of male gonad development (GO:2000020) NEW7.650.003CITED2, GATA4
regulation of DNA-templated transcription, initiation (GO:2000142) NEW6.290.015NKX2-5, GATA4
positive regulation of heart contraction (GO:0045823) NEW6.150.026NKX2-5, GATA4
regulation of organ morphogenesis (GO:2000027) NEW4.220.023CITED2, NKX2-5, GATA4
muscle tissue development (GO:0060537) NEW5.10.043NKX2-5, GATA4
atrial septum morphogenesis (GO:0060413) -7.090.011NKX2-5, GATA4
ventricular septum morphogenesis (GO:0060412) -6.590.0CITED2, NKX2-5, GATA4
cardiac septum morphogenesis (GO:0060411) -5.90.0CITED2, NKX2-5, GATA4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
macromolecular complex (GO:0032991) 1.353CITED2, NKX2-5, GATA4
intracellular membrane-bounded organelle (GO:0043231) 0.63CITED2, NKX2-5, GATA4
nucleus (GO:0005634) 1.073CITED2, NKX2-5, GATA4
cell part (GO:0044464) 0.113CITED2, NKX2-5, GATA4
intracellular organelle part (GO:0044446) 0.813CITED2, NKX2-5, GATA4
intracellular organelle (GO:0043229) 0.513CITED2, NKX2-5, GATA4
nuclear part (GO:0044428) 1.553CITED2, NKX2-5, GATA4
intracellular part (GO:0044424) 0.283CITED2, NKX2-5, GATA4
membrane-bounded organelle (GO:0043227) 0.473CITED2, NKX2-5, GATA4
organelle (GO:0043226) 0.43CITED2, NKX2-5, GATA4
organelle part (GO:0044422) 0.793CITED2, NKX2-5, GATA4
cytoplasm (GO:0005737) 1.012CITED2, NKX2-5
protein complex (GO:0043234) 1.512NKX2-5, GATA4
nuclear transcription factor complex (GO:0044798) 4.952NKX2-5, GATA4
RNA polymerase II transcription factor complex (GO:0090575) 5.182NKX2-5, GATA4
transcription factor complex (GO:0005667) 4.12NKX2-5, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
cell-cell contact zone (GO:0044291) NEW5.690.009NKX2-5, GATA4