Disease table of ATRIAL SEPTAL DEFECT OMIM ID: PS108800

Gene-disease associations table

GeneAssociated with ATRIAL SEPTAL DEFECT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TLL1ClinVar, OMIM, HUMSAVARHGNC link4q32.31PS108800
MYH6ClinVar, OMIM, HUMSAVARHGNC link14q11.26PS192600, 234750, PS108800, PS115200, 140500, PS608567
ACTC1ClinVar, OMIM, HUMSAVARHGNC link15q144PS108800, PS192600, PS115200, PS604169
TBX20ClinVar, OMIM, HUMSAVARHGNC link7p14.21PS108800
GATA6ClinVar, OMIM, HUMSAVARHGNC link18q11.25600001, PS108800, 217095, PS606215, 187500
CITED2OMIMHGNC link6q24.12PS108800, PS614429
GATA4ClinVar, OMIM, HUMSAVARHGNC link8p23.15PS614429, PS108800, 615542, PS606215, 187500
NKX2-5ClinVar, OMIM, HUMSAVARHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TBX20YES1FGF100
GATA6YES9DKK1, PLAU, CYP17A1, APOA1, CAV1, CYP11A1, VWF, SULT2A1, DAB20
CITED2YES3MMP1, MMP13, HIF1A0
GATA4YES22NKX2-5, FGF10, HDAC9, CYP17A1, NOS3, CCND2, BMP4, HESX1, HAMP, FCGR3B, STAR, ERBB2, FABP2, IAPP, NPPA, AMH, SUMO1, NPPB, IL5, SGPL1, FCGR2B, MEF2C1NKX2-5
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL11GATA4
NANOGNO23GATA4, GATA2, FGF4, CGB, GDF3, AFP, POU5F1, GATA6, CGA, KDR, LAMB1, L1TD1, MTF2, DKK1, CDC25A, SEMA6A, SOX1, YES1, LXN, CDK6, CDX2, CCND1, KLF22GATA6, GATA4
HEY2NO3GATA6, GATA4, ACTA22GATA6, GATA4
HEY1NO9GATA6, PROX1, ACTA2, GATA4, CCL2, BMP2, KDR, TNFRSF12A, OCLN2GATA6, GATA4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
MYH6YES3JARID2, TBX5, ELK30
ACTC1YES1YY10
GATA6YES4HEY2, HEY1, NANOG, POU5F10
CITED2YES2HDAC9, NR5A10
GATA4YES4HEY2, HEY1, NKX2-5, NANOG1NKX2-5
NKX2-5YES1GATA41GATA4
CYP17A1NO12SP1, NR5A1, PIAS1, GATA4, GATA6, NFIC, NR2F1, NR4A1, CREB1, NR0B1, SP3, SMAD32GATA6, GATA4
NPPBNO7XBP1, NKX2-5, GATA4, TEF, SHOX, RELA, NFKB12NKX2-5, GATA4
FGF10NO3TBX20, GATA4, ISL12TBX20, GATA4
MEF2CNO5NKX2-5, GFI1B, GATA4, ISL1, HDAC72NKX2-5, GATA4
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MYH6ACTC1No3MCM2, TPM1, HSPB2
ACTC1GATA6No1SP1
ACTC1GATA4No1SP1
TBX20NKX2-5No1TLE1
GATA6CITED2No1EP300
GATA6GATA4No2SP1, EP300
GATA6NKX2-5No1EWSR1
CITED2GATA4No2MAPK1, EP300
GATA4NKX2-5Yes7JARID2, FOXE1, ID3, TBX5, ID2, KDM6A, ID1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TLL1GATA4No-1CHRD
TLL1NKX2-5No-1CHRD
MYH6ACTC1Yesbinding21TPM4, TPM1, MYH11, MYH7, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, UBC, MYH10, MYH4, MYL2, MYL3
MYH6GATA6No-1MYH11
MYH6GATA4No-3JARID2, ACTA1, MYL2
MYH6NKX2-5No-2JARID2, MYL2
ACTC1GATA6No-1MYH11
ACTC1GATA4No-2MYL2, SRF
ACTC1NKX2-5No-2MYL2, SRF
GATA6CITED2No-2MED1, EP300
GATA6GATA4Yesactivation, binding15SP1, ZFPM2, ZFPM1, NKX2-1, KLF13, HEY2, HEY1, STAR, CYP17A1, CDK9, MYOCD, SMAD2, BMP2, GATA3, EP300
GATA6NKX2-5No-5BMP2, CALR, MYOCD, SMAD2, GATA4
CITED2GATA4No-3WT1, EPO, EP300
GATA4NKX2-5Yesactivation, binding29BMPR1A, BMP4, SMAD4, ATF2, BMP7, BMP5, SRF, SUMO1, SMAD6, MAP3K7, SMAD3, HAND2, SMARCD3, SMAD5, CHRD, BMPR2, MEF2A, SMAD2, ID2, NFATC1, NOG, JARID2, BCL2, MYL2, TBX5, BMP10, MYOCD, BMP2, MEF2C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
GATA4NKX2-5yes, they interact but maybe not in complexGATA4 acts as a transcriptional activator of ANF in cooperation with NKX2-5. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Hypertrophic cardiomyopathy (HCM)hsa054106.212ACTC1, MYH6
Dilated cardiomyopathyhsa054146.082ACTC1, MYH6
Thyroid hormone signaling pathwayhsa049195.822MYH6, GATA4
Cardiac muscle contractionhsa042606.342ACTC1, MYH6
Adrenergic signaling in cardiomyocyteshsa042615.442ACTC1, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
Cardiovascular diseasesNEW5.060.047ACTC1, MYH6
Cardiac muscle contraction (hsa04260) -6.340.008ACTC1, MYH6
Hypertrophic cardiomyopathy (HCM) (hsa05410) -6.210.01ACTC1, MYH6
Thyroid hormone signaling pathway (hsa04919) -5.820.016MYH6, GATA4
Dilated cardiomyopathy (hsa05414) -6.080.012ACTC1, MYH6
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.028ACTC1, MYH6
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Generic Transcription PathwayR-HSA-2124363.862NKX2-5, GATA4
Gene ExpressionR-HSA-741602.722NKX2-5, GATA4
Muscle contractionR-HSA-3970146.962ACTC1, MYH6
Striated Muscle ContractionR-HSA-3905227.812ACTC1, MYH6
YAP1- and WWTR1 (TAZ)-stimulated gene expressionR-HSA-20327858.122NKX2-5, GATA4
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882GATA6, GATA4
HemostasisR-HSA-1095823.982GATA6, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
Muscle contraction (R-HSA-397014) -6.960.021ACTC1, MYH6
Striated Muscle Contraction (R-HSA-390522) -7.810.006ACTC1, MYH6
YAP1- and WWTR1 (TAZ)-stimulated gene expression (R-HSA-2032785) -8.120.004NKX2-5, GATA4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
protein binding (GO:0005515) 0.467GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
organic cyclic compound binding (GO:0097159) 1.056GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
heterocyclic compound binding (GO:1901363) 1.066GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.655GATA6, TBX20, CITED2, GATA4, NKX2-5
transcription factor binding (GO:0008134) 3.465GATA6, TBX20, CITED2, GATA4, NKX2-5
nucleic acid binding transcription factor activity (GO:0001071) 2.655GATA6, TBX20, NKX2-5, GATA4, CITED2
RNA polymerase II transcription factor binding (GO:0001085) 5.084GATA6, TBX20, CITED2, GATA4
transcription regulatory region DNA binding (GO:0044212) 3.034GATA6, TBX20, NKX2-5, GATA4
sequence-specific double-stranded DNA binding (GO:1990837) 3.24GATA6, TBX20, NKX2-5, GATA4
transcription factor activity, transcription factor binding (GO:0000989) 3.364CITED2, TBX20, NKX2-5, GATA4
sequence-specific DNA binding (GO:0043565) 2.794GATA6, TBX20, NKX2-5, GATA4
regulatory region nucleic acid binding (GO:0001067) 3.034GATA6, TBX20, NKX2-5, GATA4
transcription factor activity, protein binding (GO:0000988) 3.354CITED2, TBX20, NKX2-5, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.364GATA6, TBX20, NKX2-5, GATA4
transcription cofactor activity (GO:0003712) 3.444CITED2, TBX20, NKX2-5, GATA4
enzyme binding (GO:0019899) 2.274GATA6, CITED2, GATA4, MYH6
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.984GATA6, TBX20, NKX2-5, GATA4
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076) 4.844CITED2, TBX20, NKX2-5, GATA4
macromolecular complex binding (GO:0044877) 2.614GATA6, CITED2, GATA4, NKX2-5
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.374GATA6, TBX20, NKX2-5, GATA4
nucleic acid binding (GO:0003676) 1.444GATA6, TBX20, NKX2-5, GATA4
DNA binding (GO:0003677) 1.924GATA6, TBX20, NKX2-5, GATA4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.244GATA6, TBX20, NKX2-5, GATA4
double-stranded DNA binding (GO:0003690) 3.094GATA6, TBX20, NKX2-5, GATA4
chromatin binding (GO:0003682) 3.644GATA6, CITED2, GATA4, NKX2-5
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.294GATA6, TBX20, NKX2-5, GATA4
regulatory region DNA binding (GO:0000975) 3.034GATA6, TBX20, NKX2-5, GATA4
RNA polymerase II transcription cofactor activity (GO:0001104) 5.223CITED2, TBX20, NKX2-5
hydrolase activity (GO:0016787) 1.93TLL1, ACTC1, MYH6
transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) 5.283CITED2, TBX20, NKX2-5
transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190) 5.773CITED2, TBX20, NKX2-5
activating transcription factor binding (GO:0033613) 5.683CITED2, TBX20, GATA4
transition metal ion binding (GO:0046914) 2.483GATA6, TLL1, GATA4
catalytic activity (GO:0003824) 1.053TLL1, ACTC1, MYH6
transcriptional repressor activity, RNA polymerase II activating transcription factor binding (GO:0098811) 5.773CITED2, TBX20, NKX2-5
transcription coactivator activity (GO:0003713) 4.043CITED2, TBX20, GATA4
cation binding (GO:0043169) 1.43GATA6, TLL1, GATA4
ion binding (GO:0043167) 1.363GATA6, TLL1, GATA4
protein kinase binding (GO:0019901) 3.443GATA6, MYH6, GATA4
kinase binding (GO:0019900) 3.323GATA6, MYH6, GATA4
zinc ion binding (GO:0008270) 2.663GATA6, TLL1, GATA4
metal ion binding (GO:0046872) 1.413GATA6, TLL1, GATA4
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ACTC1, MYH6
core promoter proximal region DNA binding (GO:0001159) 3.822TBX20, NKX2-5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232GATA6, NKX2-5
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) 4.312TBX20, NKX2-5
ATPase activity (GO:0016887) 3.652ACTC1, MYH6
nucleoside phosphate binding (GO:1901265) 1.962ACTC1, MYH6
nucleoside binding (GO:0001882) 2.212ACTC1, MYH6
nucleotide binding (GO:0000166) 1.962ACTC1, MYH6
purine nucleoside binding (GO:0001883) 2.222ACTC1, MYH6
ribonucleoside binding (GO:0032549) 2.222ACTC1, MYH6
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832TBX20, NKX2-5
purine nucleotide binding (GO:0017076) 2.192ACTC1, MYH6
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942TBX20, NKX2-5
ATP binding (GO:0005524) 2.432ACTC1, MYH6
nucleoside-triphosphatase activity (GO:0017111) 3.092ACTC1, MYH6
small molecule binding (GO:0036094) 1.892ACTC1, MYH6
RNA polymerase II transcription coactivator activity (GO:0001105) 6.152CITED2, TBX20
RNA polymerase II activating transcription factor binding (GO:0001102) 6.132CITED2, TBX20
SMAD binding (GO:0046332) 5.452CITED2, GATA4
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032ACTC1, MYH6
cytoskeletal protein binding (GO:0008092) 3.022ACTC1, MYH6
carbohydrate derivative binding (GO:0097367) 2.032ACTC1, MYH6
adenyl nucleotide binding (GO:0030554) 2.42ACTC1, MYH6
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032ACTC1, MYH6
pyrophosphatase activity (GO:0016462) 3.042ACTC1, MYH6
adenyl ribonucleotide binding (GO:0032559) 2.412ACTC1, MYH6
purine ribonucleotide binding (GO:0032555) 2.22ACTC1, MYH6
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882TBX20, NKX2-5
purine ribonucleoside binding (GO:0032550) 2.222ACTC1, MYH6
ribonucleotide binding (GO:0032553) 2.192ACTC1, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
activating transcription factor binding (GO:0033613) -5.680.0CITED2, TBX20, NKX2-5, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) -5.230.036GATA6, NKX2-5, GATA4
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) -4.840.0CITED2, TBX20, NKX2-5, GATA4
nucleic acid binding transcription factor activity (GO:0001071) -2.650.005GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
sequence-specific DNA binding (GO:0043565) -2.790.0GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190) -5.770.0CITED2, TBX20, NKX2-5
microfilament motor activity (GO:0000146) NEW6.650.015ACTC1, MYH6
transcription coactivator activity (GO:0003713) -4.040.002CITED2, TBX20, MYH6, GATA4, NKX2-5
transcription cofactor activity (GO:0003712) -3.440.004TBX20, CITED2, ACTC1, NKX2-5, GATA4
transcription factor binding transcription factor activity (GO:0000989) -3.360.049TBX20, CITED2, ACTC1, NKX2-5, GATA4
protein binding transcription factor activity (GO:0000988) -3.350.05ACTC1, CITED2, TBX20, NKX2-5, GATA4
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.0GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
transcription regulatory region DNA binding (GO:0044212) -3.030.001GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
transcription factor binding (GO:0008134) -3.460.0GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulatory region nucleic acid binding (GO:0001067) -3.030.001GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
actin-dependent ATPase activity (GO:0030898) NEW7.170.004ACTC1, MYH6
SMAD binding (GO:0046332) -5.450.041CITED2, NKX2-5, GATA4
RNA polymerase II transcription coactivator activity (GO:0001105) -6.150.004CITED2, TBX20, NKX2-5
enhancer binding (GO:0035326) NEW5.210.018MYH6, GATA4, NKX2-5
RNA polymerase II activating transcription factor binding (GO:0001102) -6.130.011CITED2, TBX20, NKX2-5
RNA polymerase II transcription factor binding (GO:0001085) -5.080.001GATA6, TBX20, CITED2, GATA4, NKX2-5
RNA polymerase II transcription cofactor activity (GO:0001104) -5.220.0CITED2, TBX20, NKX2-5, GATA4
sequence-specific DNA binding transcription factor activity (GO:0003700) -2.650.005GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.02GATA6, MYH6, GATA4, NKX2-5
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
regulatory region DNA binding (GO:0000975) -3.030.001GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
chromatin binding (GO:0003682) -3.640.011NKX2-5, GATA6, CITED2, GATA4, MYH6
zinc ion binding (GO:0008270) -2.660.018GATA6, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.368GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
multicellular organismal process (GO:0032501) 1.458GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
single-multicellular organism process (GO:0044707) 1.788GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
cellular process (GO:0009987) 0.268GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
single-organism developmental process (GO:0044767) 1.498GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
single-organism cellular process (GO:0044763) 0.658GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
single-organism process (GO:0044699) 0.488GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
primary metabolic process (GO:0044238) 0.697GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
macromolecule metabolic process (GO:0043170) 0.837GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
regulation of metabolic process (GO:0019222) 1.027GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
regulation of macromolecule metabolic process (GO:0060255) 1.087GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
cellular developmental process (GO:0048869) 1.827GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
anatomical structure development (GO:0048856) 1.587GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
regulation of cellular process (GO:0050794) 0.57GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
organic substance metabolic process (GO:0071704) 0.637GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
biological regulation (GO:0065007) 0.397GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
metabolic process (GO:0008152) 0.587GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
regulation of gene expression (GO:0010468) 1.377GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
anatomical structure morphogenesis (GO:0009653) 2.537GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
regulation of biological process (GO:0050789) 0.457GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
anatomical structure formation involved in morphogenesis (GO:0048646) 3.017GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
positive regulation of metabolic process (GO:0009893) 1.746GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
regulation of cellular biosynthetic process (GO:0031326) 1.386GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
cell differentiation (GO:0030154) 2.146GATA6, TBX20, GATA4, NKX2-5, CITED2, TLL1
regulation of cellular metabolic process (GO:0031323) 1.076GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
cellular nitrogen compound metabolic process (GO:0034641) 1.226GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
nitrogen compound metabolic process (GO:0006807) 1.136GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
positive regulation of gene expression (GO:0010628) 2.356GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
multicellular organism development (GO:0007275) 2.546GATA6, TBX20, NKX2-5, CITED2, MYH6, TLL1
organic cyclic compound metabolic process (GO:1901360) 1.266GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of primary metabolic process (GO:0080090) 1.086GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
nucleobase-containing compound metabolic process (GO:0006139) 1.356GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
positive regulation of macromolecule metabolic process (GO:0010604) 1.816GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
cellular macromolecule metabolic process (GO:0044260) 0.936GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.466GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of developmental process (GO:0050793) 2.16GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of macromolecule biosynthetic process (GO:0010556) 1.436GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
tissue morphogenesis (GO:0048729) 3.876TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
positive regulation of biological process (GO:0048518) 1.26GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
negative regulation of biological process (GO:0048519) 1.336GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
cellular aromatic compound metabolic process (GO:0006725) 1.36GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of biosynthetic process (GO:0009889) 1.376GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of nucleic acid-templated transcription (GO:1903506) 1.556GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of nitrogen compound metabolic process (GO:0051171) 1.366GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of multicellular organismal process (GO:0051239) 1.876GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of RNA biosynthetic process (GO:2001141) 1.556GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
heterocycle metabolic process (GO:0046483) 1.316GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of RNA metabolic process (GO:0051252) 1.526GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
cellular metabolic process (GO:0044237) 0.696GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of transcription, DNA-templated (GO:0006355) 1.566GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.246GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of multicellular organismal development (GO:2000026) 2.316GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
negative regulation of cellular process (GO:0048523) 1.416GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
RNA biosynthetic process (GO:0032774) 1.845GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of biosynthetic process (GO:0009891) 2.295GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of cellular metabolic process (GO:0031325) 1.815GATA6, TBX20, CITED2, GATA4, NKX2-5
regulation of response to stimulus (GO:0048583) 1.545GATA6, TBX20, CITED2, GATA4, NKX2-5
nucleic acid metabolic process (GO:0090304) 1.465GATA6, TBX20, CITED2, GATA4, NKX2-5
cellular biosynthetic process (GO:0044249) 1.375GATA6, TBX20, CITED2, GATA4, NKX2-5
muscle system process (GO:0003012) 4.185TBX20, GATA6, ACTC1, MYH6, NKX2-5
cellular macromolecule biosynthetic process (GO:0034645) 1.665GATA6, TBX20, CITED2, GATA4, NKX2-5
regulation of signaling (GO:0023051) 1.725GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.355GATA6, TBX20, CITED2, GATA4, NKX2-5
regulation of cell communication (GO:0010646) 1.735GATA6, TBX20, CITED2, GATA4, NKX2-5
organic cyclic compound biosynthetic process (GO:1901362) 1.665GATA6, TBX20, CITED2, GATA4, NKX2-5
nucleic acid-templated transcription (GO:0097659) 1.915GATA6, TBX20, CITED2, GATA4, NKX2-5
organic substance biosynthetic process (GO:1901576) 1.345GATA6, TBX20, CITED2, GATA4, NKX2-5
regulation of signal transduction (GO:0009966) 1.845GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of multicellular organismal process (GO:0051240) 2.495GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of cellular biosynthetic process (GO:0031328) 2.35GATA6, TBX20, CITED2, GATA4, NKX2-5
animal organ development (GO:0048513) 2.535NKX2-5, GATA6, CITED2, GATA4, MYH6
heterocycle biosynthetic process (GO:0018130) 1.75GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.565GATA6, TBX20, CITED2, GATA4, NKX2-5
tube morphogenesis (GO:0035239) 4.355GATA6, TBX20, CITED2, GATA4, NKX2-5
cell development (GO:0048468) 3.285NKX2-5, GATA6, CITED2, GATA4, MYH6
tissue development (GO:0009888) 3.275GATA6, TBX20, CITED2, GATA4, NKX2-5
biosynthetic process (GO:0009058) 1.325GATA6, TBX20, CITED2, GATA4, NKX2-5
macromolecule biosynthetic process (GO:0009059) 1.615GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of transcription, DNA-templated (GO:0045893) 2.565GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.295GATA6, TBX20, CITED2, GATA4, NKX2-5
nucleobase-containing compound biosynthetic process (GO:0034654) 1.725GATA6, TBX20, CITED2, GATA4, NKX2-5
system process (GO:0003008) 2.35ACTC1, GATA6, TBX20, MYH6, NKX2-5
RNA metabolic process (GO:0016070) 1.595GATA6, TBX20, CITED2, GATA4, NKX2-5
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of developmental process (GO:0051094) 2.775GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of RNA metabolic process (GO:0051254) 2.515GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of RNA biosynthetic process (GO:1902680) 2.545GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.395GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.815GATA6, TBX20, CITED2, GATA4, NKX2-5
transcription, DNA-templated (GO:0006351) 1.915GATA6, TBX20, CITED2, GATA4, NKX2-5
aromatic compound biosynthetic process (GO:0019438) 1.75GATA6, TBX20, CITED2, GATA4, NKX2-5
cardiac septum morphogenesis (GO:0060411) 5.95GATA6, TBX20, CITED2, GATA4, NKX2-5
positive regulation of cellular process (GO:0048522) 1.35GATA6, TBX20, CITED2, GATA4, NKX2-5
regulation of developmental growth (GO:0048638) 4.044GATA6, TBX20, NKX2-5, MYH6
negative regulation of metabolic process (GO:0009892) 1.934GATA6, TBX20, CITED2, NKX2-5
negative regulation of biosynthetic process (GO:0009890) 2.474GATA6, TBX20, CITED2, NKX2-5
negative regulation of cellular biosynthetic process (GO:0031327) 2.494GATA6, TBX20, CITED2, NKX2-5
negative regulation of cellular metabolic process (GO:0031324) 2.014GATA6, TBX20, CITED2, NKX2-5
regulation of heart growth (GO:0060420) 5.974GATA6, TBX20, NKX2-5, MYH6
negative regulation of gene expression (GO:0010629) 2.484GATA6, TBX20, CITED2, NKX2-5
regulation of cell death (GO:0010941) 2.434GATA6, ACTC1, CITED2, NKX2-5
regulation of apoptotic process (GO:0042981) 2.54GATA6, ACTC1, CITED2, NKX2-5
cellular component organization or biogenesis (GO:0071840) 1.224TLL1, ACTC1, MYH6, NKX2-5
pattern specification process (GO:0007389) 3.794CITED2, TBX20, NKX2-5, GATA4
negative regulation of macromolecule metabolic process (GO:0010605) 2.014GATA6, TBX20, CITED2, NKX2-5
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.124GATA6, TBX20, CITED2, NKX2-5
regulation of growth (GO:0040008) 3.264GATA6, TBX20, NKX2-5, MYH6
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64GATA6, TBX20, CITED2, NKX2-5
cellular component organization (GO:0016043) 1.244TLL1, ACTC1, NKX2-5, MYH6
heart looping (GO:0001947) 5.654CITED2, TBX20, NKX2-5, GATA4
regulation of organ growth (GO:0046620) 5.414GATA6, TBX20, NKX2-5, MYH6
regulation of programmed cell death (GO:0043067) 2.494GATA6, ACTC1, CITED2, NKX2-5
negative regulation of apoptotic process (GO:0043066) 3.044GATA6, ACTC1, CITED2, NKX2-5
transcription from RNA polymerase II promoter (GO:0006366) 3.384GATA6, TBX20, NKX2-5, GATA4
epithelial tube morphogenesis (GO:0060562) 5.124CITED2, TBX20, NKX2-5, GATA4
negative regulation of programmed cell death (GO:0043069) 3.024GATA6, ACTC1, CITED2, NKX2-5
embryonic morphogenesis (GO:0048598) 3.724CITED2, TBX20, NKX2-5, GATA4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.394GATA6, TBX20, CITED2, GATA4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554GATA6, TBX20, CITED2, NKX2-5
muscle contraction (GO:0006936) 4.374ACTC1, TBX20, NKX2-5, MYH6
morphogenesis of an epithelium (GO:0002009) 4.084CITED2, TBX20, NKX2-5, GATA4
cardiac muscle tissue morphogenesis (GO:0055008) 5.84ACTC1, TBX20, NKX2-5, MYH6
negative regulation of cell death (GO:0060548) 2.954GATA6, ACTC1, CITED2, NKX2-5
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.714GATA6, TBX20, CITED2, NKX2-5
negative regulation of RNA biosynthetic process (GO:1902679) 2.74GATA6, TBX20, CITED2, NKX2-5
negative regulation of transcription, DNA-templated (GO:0045892) 2.754GATA6, TBX20, CITED2, NKX2-5
regionalization (GO:0003002) 4.244CITED2, TBX20, NKX2-5, GATA4
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474GATA6, TBX20, CITED2, NKX2-5
response to chemical (GO:0042221) 1.984GATA6, ACTC1, CITED2, GATA4
negative regulation of RNA metabolic process (GO:0051253) 2.664GATA6, TBX20, CITED2, NKX2-5
response to organic substance (GO:0010033) 2.24GATA6, ACTC1, CITED2, GATA4
embryonic heart tube morphogenesis (GO:0003143) 5.574CITED2, TBX20, NKX2-5, GATA4
cardiac septum development (GO:0003279) 5.944CITED2, TBX20, NKX2-5, GATA4
response to stimulus (GO:0050896) 1.224GATA6, ACTC1, CITED2, GATA4
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.534GATA6, TBX20, CITED2, NKX2-5
muscle tissue morphogenesis (GO:0060415) 5.624TBX20, ACTC1, MYH6, NKX2-5
positive regulation of cell proliferation (GO:0008284) 3.013GATA6, TBX20, NKX2-5
cellular component assembly (GO:0022607) 2.143ACTC1, NKX2-5, MYH6
regulation of stem cell differentiation (GO:2000736) 6.263GATA6, NKX2-5, GATA4
actomyosin structure organization (GO:0031032) 5.43ACTC1, NKX2-5, MYH6
regulation of anatomical structure morphogenesis (GO:0022603) 2.793GATA6, CITED2, GATA4
atrial septum morphogenesis (GO:0060413) 7.093TBX20, NKX2-5, GATA4
positive regulation of stem cell differentiation (GO:2000738) 7.023GATA6, NKX2-5, GATA4
positive regulation of response to stimulus (GO:0048584) 2.183GATA6, CITED2, GATA4
regulation of muscle organ development (GO:0048634) 5.073GATA6, TBX20, NKX2-5
actin cytoskeleton organization (GO:0030036) 4.13ACTC1, NKX2-5, MYH6
movement of cell or subcellular component (GO:0006928) 2.613TBX20, ACTC1, MYH6
striated muscle contraction (GO:0006941) 5.373ACTC1, NKX2-5, MYH6
embryo development (GO:0009790) 4.23GATA6, CITED2, MYH6
circulatory system process (GO:0003013) 4.383TBX20, ACTC1, NKX2-5
signal transduction (GO:0007165) 1.283CITED2, NKX2-5, MYH6
cell surface receptor signaling pathway (GO:0007166) 2.093CITED2, NKX2-5, MYH6
striated muscle cell differentiation (GO:0051146) 5.693GATA6, NKX2-5, GATA4
regulation of localization (GO:0032879) 1.943CITED2, NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) 7.783GATA6, NKX2-5, GATA4
cardiac muscle contraction (GO:0060048) 5.883ACTC1, NKX2-5, MYH6
positive regulation of cardioblast differentiation (GO:0051891) 8.123GATA6, NKX2-5, GATA4
regulation of cardiac muscle cell proliferation (GO:0060043) 6.333GATA6, TBX20, NKX2-5
cell fate commitment (GO:0045165) 4.723GATA6, NKX2-5, GATA4
outflow tract morphogenesis (GO:0003151) 5.973CITED2, TBX20, NKX2-5
cellular response to stimulus (GO:0051716) 1.973GATA6, CITED2, GATA4
cardiac chamber morphogenesis (GO:0003206) 6.363TBX20, NKX2-5, GATA4
(GO:1905207) 6.43GATA6, NKX2-5, GATA4
regulation of system process (GO:0044057) 3.533MYH6, GATA4, NKX2-5
regulation of cell proliferation (GO:0042127) 2.413GATA6, TBX20, NKX2-5
positive regulation of signal transduction (GO:0009967) 2.53GATA6, CITED2, GATA4
cell proliferation (GO:0008283) 3.233CITED2, TBX20, NKX2-5
gonad development (GO:0008406) 4.923GATA6, CITED2, GATA4
cardiac ventricle morphogenesis (GO:0003208) 6.553TBX20, NKX2-5, GATA4
cellular response to organic substance (GO:0071310) 2.783GATA6, CITED2, GATA4
cellular response to chemical stimulus (GO:0070887) 2.573GATA6, CITED2, GATA4
reproductive process (GO:0022414) 2.553GATA6, CITED2, GATA4
positive regulation of cell communication (GO:0010647) 2.413GATA6, CITED2, GATA4
chordate embryonic development (GO:0043009) 4.383GATA6, CITED2, MYH6
regulation of biological quality (GO:0065008) 1.683GATA6, MYH6, GATA4
regulation of muscle tissue development (GO:1901861) 5.073GATA6, TBX20, NKX2-5
regulation of striated muscle tissue development (GO:0016202) 5.093GATA6, TBX20, NKX2-5
reproductive structure development (GO:0048608) 4.083GATA6, CITED2, GATA4
actin filament-based process (GO:0030029) 3.943ACTC1, NKX2-5, MYH6
cardiac muscle cell differentiation (GO:0055007) 6.293GATA6, NKX2-5, GATA4
(GO:1905209) 6.733GATA6, NKX2-5, GATA4
regulation of cardiac muscle tissue development (GO:0055024) 5.863GATA6, TBX20, NKX2-5
regulation of heart contraction (GO:0008016) 4.353MYH6, GATA4, NKX2-5
cardiocyte differentiation (GO:0035051) 6.023GATA6, NKX2-5, GATA4
regulation of cellular response to growth factor stimulus (GO:0090287) 4.293GATA6, CITED2, GATA4
regulation of cardiac muscle tissue growth (GO:0055021) 6.123GATA6, TBX20, NKX2-5
positive regulation of cell differentiation (GO:0045597) 3.013GATA6, NKX2-5, GATA4
developmental process involved in reproduction (GO:0003006) 3.363GATA6, CITED2, GATA4
regulation of cell differentiation (GO:0045595) 2.423GATA6, NKX2-5, GATA4
in utero embryonic development (GO:0001701) 4.43GATA6, CITED2, MYH6
regulation of blood circulation (GO:1903522) 4.053MYH6, GATA4, NKX2-5
positive regulation of signaling (GO:0023056) 2.413GATA6, CITED2, GATA4
mesenchyme development (GO:0060485) 5.73CITED2, NKX2-5, GATA4
cellular component assembly involved in morphogenesis (GO:0010927) 4.293ACTC1, NKX2-5, MYH6
response to abiotic stimulus (GO:0009628) 2.83GATA6, CITED2, GATA4
organelle assembly (GO:0070925) 3.753ACTC1, NKX2-5, MYH6
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.63CITED2, NKX2-5, MYH6
organelle organization (GO:0006996) 2.023ACTC1, NKX2-5, MYH6
myofibril assembly (GO:0030239) 6.433ACTC1, NKX2-5, MYH6
heart development (GO:0007507) 4.243CITED2, NKX2-5, MYH6
single organism reproductive process (GO:0044702) 2.733GATA6, CITED2, GATA4
cytoskeleton organization (GO:0007010) 3.223ACTC1, NKX2-5, MYH6
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.123GATA6, CITED2, GATA4
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243CITED2, NKX2-5, MYH6
protein metabolic process (GO:0019538) 1.453GATA6, TLL1, MYH6
outflow tract septum morphogenesis (GO:0003148) 7.093GATA6, TBX20, NKX2-5
response to drug (GO:0042493) 3.713GATA6, ACTC1, GATA4
single-organism organelle organization (GO:1902589) 2.683ACTC1, NKX2-5, MYH6
embryo development ending in birth or egg hatching (GO:0009792) 4.353GATA6, CITED2, MYH6
male gonad development (GO:0008584) 5.083GATA6, CITED2, GATA4
system development (GO:0048731) 2.923TLL1, CITED2, NKX2-5
gland development (GO:0048732) 4.153GATA6, CITED2, NKX2-5
muscle cell differentiation (GO:0042692) 5.093GATA6, NKX2-5, GATA4
hemostasis (GO:0007599) 4.52GATA6, GATA4
negative regulation of response to stimulus (GO:0048585) 2.522TBX20, NKX2-5
blood coagulation (GO:0007596) 4.522GATA6, GATA4
BMP signaling pathway (GO:0030509) 5.332NKX2-5, MYH6
heart process (GO:0003015) 7.022ACTC1, NKX2-5
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792NKX2-5, MYH6
single-organism metabolic process (GO:0044710) 1.632GATA6, MYH6
positive regulation of cell cycle (GO:0045787) 3.942GATA6, CITED2
negative regulation of signal transduction (GO:0009968) 2.752TBX20, NKX2-5
adult heart development (GO:0007512) 7.162NKX2-5, MYH6
response to growth factor (GO:0070848) 4.142GATA6, CITED2
response to mechanical stimulus (GO:0009612) 4.412CITED2, GATA4
blood vessel morphogenesis (GO:0048514) 5.322CITED2, TBX20
epithelial cell differentiation (GO:0030855) 3.982GATA6, GATA4
columnar/cuboidal epithelial cell differentiation (GO:0002065) 5.842GATA6, GATA4
regulation of muscle contraction (GO:0006937) 4.752NKX2-5, GATA4
muscle filament sliding (GO:0030049) 6.092ACTC1, MYH6
actin filament-based movement (GO:0030048) 5.542ACTC1, MYH6
regulation of cellular component organization (GO:0051128) 2.012TBX20, NKX2-5
positive regulation of BMP signaling pathway (GO:0030513) 6.262GATA6, GATA4
regulation of cardiac muscle contraction (GO:0055117) 5.572NKX2-5, GATA4
regulation of BMP signaling pathway (GO:0030510) 5.362GATA6, GATA4
cardiac right ventricle morphogenesis (GO:0003215) 7.432TBX20, GATA4
response to external stimulus (GO:0009605) 2.552CITED2, GATA4
negative regulation of signaling (GO:0023057) 2.652TBX20, NKX2-5
Wnt signaling pathway (GO:0016055) 3.882NKX2-5, MYH6
heart contraction (GO:0060047) 7.022ACTC1, NKX2-5
cellular response to stress (GO:0033554) 2.512GATA6, CITED2
organophosphate metabolic process (GO:0019637) 3.042GATA6, MYH6
ventricular septum morphogenesis (GO:0060412) 6.592CITED2, NKX2-5
intestinal epithelial cell differentiation (GO:0060575) 7.942GATA6, GATA4
positive regulation of striated muscle tissue development (GO:0045844) 5.692GATA6, TBX20
ventricular septum development (GO:0003281) 6.362CITED2, GATA4
organ morphogenesis (GO:0009887) 3.552CITED2, NKX2-5
regulation of vasculature development (GO:1901342) 4.262GATA6, GATA4
phosphorus metabolic process (GO:0006793) 2.152GATA6, MYH6
cellular protein metabolic process (GO:0044267) 1.632GATA6, MYH6
cardiac chamber formation (GO:0003207) 7.332TBX20, NKX2-5
positive regulation of muscle tissue development (GO:1901863) 5.672GATA6, TBX20
positive regulation of cardiac muscle tissue development (GO:0055025) 6.332GATA6, TBX20
positive regulation of cardiac muscle tissue growth (GO:0055023) 6.592GATA6, TBX20
programmed cell death (GO:0012501) 3.12ACTC1, NKX2-5
response to stress (GO:0006950) 1.82GATA6, CITED2
coagulation (GO:0050817) 4.512GATA6, GATA4
regulation of protein complex assembly (GO:0043254) 3.832TBX20, NKX2-5
vasculogenesis (GO:0001570) 5.652CITED2, NKX2-5
canonical Wnt signaling pathway (GO:0060070) 5.262NKX2-5, MYH6
response to decreased oxygen levels (GO:0036293) 4.092GATA6, CITED2
positive regulation of developmental growth (GO:0048639) 4.672GATA6, TBX20
positive regulation of muscle organ development (GO:0048636) 5.692GATA6, TBX20
positive regulation of cardiac muscle cell proliferation (GO:0060045) 6.782GATA6, TBX20
regulation of striated muscle contraction (GO:0006942) 5.382NKX2-5, GATA4
negative regulation of cell communication (GO:0010648) 2.662TBX20, NKX2-5
response to hypoxia (GO:0001666) 4.132GATA6, CITED2
positive regulation of vasculature development (GO:1904018) 4.832GATA6, GATA4
actin-myosin filament sliding (GO:0033275) 6.092ACTC1, MYH6
endocardial cushion development (GO:0003197) 7.332CITED2, GATA4
muscle cell development (GO:0055001) 5.292NKX2-5, MYH6
striated muscle cell development (GO:0055002) 5.422NKX2-5, MYH6
cardiac myofibril assembly (GO:0055003) 7.022ACTC1, NKX2-5
cardiac cell development (GO:0055006) 6.332NKX2-5, MYH6
epithelium development (GO:0060429) 4.572TBX20, NKX2-5
sarcomere organization (GO:0045214) 6.42NKX2-5, MYH6
cellular response to growth factor stimulus (GO:0071363) 4.272GATA6, CITED2
striated muscle tissue development (GO:0014706) 5.232GATA6, NKX2-5
cardiac muscle tissue development (GO:0048738) 6.332GATA6, NKX2-5
regulation of cytokine production (GO:0001817) 3.42GATA6, GATA4
cardiac muscle cell development (GO:0055013) 6.42NKX2-5, MYH6
positive regulation of growth (GO:0045927) 4.252GATA6, TBX20
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.072NKX2-5, MYH6
embryonic heart tube left/right pattern formation (GO:0060971) 8.342CITED2, NKX2-5
left/right pattern formation (GO:0060972) 7.532CITED2, NKX2-5
positive regulation of heart growth (GO:0060421) 6.432GATA6, TBX20
liver development (GO:0001889) 4.982GATA6, CITED2
cell death (GO:0008219) 3.052ACTC1, NKX2-5
regulation of body fluid levels (GO:0050878) 3.762GATA6, GATA4
regulation of angiogenesis (GO:0045765) 4.362GATA6, GATA4
positive regulation of angiogenesis (GO:0045766) 4.932GATA6, GATA4
spleen development (GO:0048536) 6.072CITED2, NKX2-5
hematopoietic or lymphoid organ development (GO:0048534) 4.492CITED2, NKX2-5
positive regulation of organ growth (GO:0046622) 6.092GATA6, TBX20
apoptotic process (GO:0006915) 3.142ACTC1, NKX2-5
embryonic heart tube development (GO:0035050) 6.732TBX20, NKX2-5
regulation of muscle system process (GO:0090257) 4.512NKX2-5, GATA4
response to estrogen (GO:0043627) 5.252GATA6, CITED2
tube development (GO:0035295) 4.412TBX20, NKX2-5
response to oxygen levels (GO:0070482) 4.022GATA6, CITED2
response to oxygen-containing compound (GO:1901700) 2.572ACTC1, GATA4
regulation of cellular component movement (GO:0051270) 3.082CITED2, GATA4
regulation of cell cycle (GO:0051726) 2.932GATA6, CITED2
regulation of cellular component biogenesis (GO:0044087) 3.082TBX20, NKX2-5
phosphate-containing compound metabolic process (GO:0006796) 2.162GATA6, MYH6
muscle tissue development (GO:0060537) 5.12GATA6, NKX2-5
actin-mediated cell contraction (GO:0070252) 5.882ACTC1, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
limb morphogenesis (GO:0035108) NEW5.050.006TBX20, MYH6, GATA4, NKX2-5
regulation of stem cell differentiation (GO:2000736) -6.260.005GATA6, NKX2-5, GATA4
positive regulation of stem cell differentiation (GO:2000738) -7.020.0GATA6, NKX2-5, GATA4
appendage morphogenesis (GO:0035107) NEW5.050.006TBX20, MYH6, GATA4, NKX2-5
male gonad development (GO:0008584) -5.080.003GATA6, CITED2, GATA4
BMP signaling pathway (GO:0030509) -5.330.046MYH6, GATA4, NKX2-5
muscle system process (GO:0003012) -4.180.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
positive regulation of cardioblast differentiation (GO:0051891) -8.120.0GATA6, NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) -7.780.0GATA6, NKX2-5, GATA4
outflow tract morphogenesis (GO:0003151) -5.970.0GATA6, CITED2, GATA4, NKX2-5
negative regulation of signal transduction (GO:0009968) -2.750.021GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6, TLL1
adult heart development (GO:0007512) -7.160.014TLL1, MYH6, GATA4, NKX2-5
positive regulation of signal transduction (GO:0009967) -2.50.001GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
organ development (GO:0048513) -2.530.03NKX2-5, GATA6, CITED2, GATA4, MYH6
blood vessel morphogenesis (GO:0048514) -5.320.004CITED2, TBX20, NKX2-5, GATA4
epithelial cell differentiation (GO:0030855) -3.980.035TBX20, GATA6, ACTC1, MYH6, GATA4
response to gonadotropin (GO:0034698) NEW6.40.04GATA6, GATA4
system process (GO:0003008) -2.30.001GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
regulation of striated muscle tissue development (GO:0016202) -5.090.0GATA6, TBX20, NKX2-5, GATA4
muscle contraction (GO:0006936) -4.370.001ACTC1, TBX20, MYH6, GATA4, NKX2-5
muscle hypertrophy in response to stress (GO:0003299) NEW7.330.012GATA6, GATA4
regionalization (GO:0003002) -4.240.001GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) -4.60.001CITED2, MYH6, GATA4, NKX2-5
cardiac right ventricle morphogenesis (GO:0003215) -7.430.005GATA6, TBX20, GATA4
single-multicellular organism process (GO:0044707) -1.780.017GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
negative regulation of signaling (GO:0023057) -2.650.028GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6, TLL1
cardiac ventricle formation (GO:0003211) NEW7.430.0MYH6, GATA4, NKX2-5
embryo development ending in birth or egg hatching (GO:0009792) -4.350.007GATA6, TBX20, MYH6, GATA4, NKX2-5
atrial septum morphogenesis (GO:0060413) -7.090.0TBX20, NKX2-5, GATA4
ventricular septum morphogenesis (GO:0060412) -6.590.001CITED2, NKX2-5, GATA4
cardiac septum morphogenesis (GO:0060411) -5.90.0GATA6, TBX20, CITED2, GATA4, NKX2-5
muscle cell differentiation (GO:0042692) -5.090.015GATA6, TBX20, NKX2-5, GATA4
muscle tissue morphogenesis (GO:0060415) -5.620.0TBX20, ACTC1, NKX2-5, GATA4, MYH6
intestinal epithelial cell differentiation (GO:0060575) -7.940.006GATA6, GATA4
embryonic organ morphogenesis (GO:0048562) NEW4.920.024CITED2, TBX20, NKX2-5, GATA4
regulation of anatomical structure morphogenesis (GO:0022603) -2.790.009GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
atrial septum development (GO:0003283) NEW7.780.01NKX2-5, GATA4
positive regulation of RNA metabolic process (GO:0051254) -2.510.044GATA6, TBX20, CITED2, GATA4, NKX2-5
heart valve morphogenesis (GO:0003179) NEW6.550.037TBX20, GATA4
embryonic axis specification (GO:0000578) NEW6.360.0GATA6, MYH6, GATA4, NKX2-5
negative regulation of transcription by transcription factor localization (GO:0010621) NEW8.630.003GATA6, NKX2-5
cardiac muscle tissue development (GO:0048738) -6.330.034TBX20, MYH6, GATA4, NKX2-5
cardiac chamber formation (GO:0003207) -7.330.0TBX20, MYH6, GATA4, NKX2-5
cardiac chamber morphogenesis (GO:0003206) -6.360.0GATA6, TBX20, MYH6, GATA4
neuron differentiation (GO:0030182) NEW4.170.016GATA6, TBX20, CITED2, GATA4, NKX2-5
anterior/posterior axis specification (GO:0009948) NEW6.170.0GATA6, MYH6, GATA4, NKX2-5
myofibril assembly (GO:0030239) -6.430.002ACTC1, NKX2-5, MYH6
gonad development (GO:0008406) -4.920.008GATA6, CITED2, GATA4
cardiac ventricle morphogenesis (GO:0003208) -6.550.031GATA6, TBX20, GATA4
negative regulation of cell proliferation (GO:0008285) NEW3.260.003GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6, TLL1
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.011GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
regulation of muscle tissue development (GO:1901861) -5.070.0GATA6, TBX20, NKX2-5, GATA4
organ morphogenesis (GO:0009887) -3.550.0GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
embryonic pattern specification (GO:0009880) NEW5.80.0GATA6, MYH6, GATA4, NKX2-5
regulation of developmental process (GO:0050793) -2.10.013GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of cardiac muscle tissue development (GO:0055024) -5.860.0GATA6, TBX20, NKX2-5, GATA4
regulation of heart contraction (GO:0008016) -4.350.016TBX20, MYH6, GATA4, NKX2-5
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.0GATA6, TBX20, NKX2-5, GATA4
canonical Wnt signaling pathway (GO:0060070) -5.260.004GATA6, MYH6, GATA4, NKX2-5
cardiac myofibril assembly (GO:0055003) -7.020.014ACTC1, NKX2-5
regulation of multicellular organismal process (GO:0051239) -1.870.037GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
vasculogenesis (GO:0001570) -5.650.0GATA6, TBX20, CITED2, GATA4, NKX2-5
muscle hypertrophy (GO:0014896) NEW6.680.026GATA6, GATA4
striated muscle hypertrophy (GO:0014897) NEW6.780.021GATA6, GATA4
regulation of cell motility (GO:2000145) NEW3.160.035GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
cellular developmental process (GO:0048869) -1.820.003GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
cardiac muscle hypertrophy in response to stress (GO:0014898) NEW7.330.012GATA6, GATA4
heart valve formation (GO:0003188) NEW7.330.031TBX20, GATA4
regulation of developmental growth (GO:0048638) -4.040.0GATA6, TBX20, MYH6, GATA4, NKX2-5
mesoderm development (GO:0007498) NEW5.720.038MYH6, GATA4, NKX2-5
cardiac muscle adaptation (GO:0014887) NEW7.330.012GATA6, GATA4
cell differentiation (GO:0030154) -2.140.008GATA6, TBX20, GATA4, NKX2-5, CITED2, TLL1
regulation of muscle organ development (GO:0048634) -5.070.0GATA6, TBX20, NKX2-5, GATA4
cellular component assembly involved in morphogenesis (GO:0010927) -4.290.04ACTC1, NKX2-5, MYH6
striated muscle contraction (GO:0006941) -5.370.001ACTC1, MYH6, GATA4, NKX2-5
positive regulation of cardiac muscle cell proliferation (GO:0060045) -6.780.002GATA6, TBX20, GATA4
regulation of striated muscle contraction (GO:0006942) -5.380.041MYH6, GATA4, NKX2-5
negative regulation of cell communication (GO:0010648) -2.660.028GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6, TLL1
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.0GATA6, TBX20, NKX2-5, GATA4
axis specification (GO:0009798) NEW5.420.0NKX2-5, GATA6, CITED2, GATA4, MYH6
ameboidal cell migration (GO:0001667) NEW4.710.037GATA6, ACTC1, MYH6, GATA4
anatomical structure morphogenesis (GO:0009653) -2.530.0GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
cardiac muscle contraction (GO:0060048) -5.880.009ACTC1, NKX2-5, MYH6
ventricular trabecula myocardium morphogenesis (GO:0003222) NEW7.330.049NKX2-5, GATA4
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) NEW9.040.001NKX2-5, GATA4
cellular response to gonadotropin stimulus (GO:0071371) NEW7.020.017GATA6, GATA4
striated muscle adaptation (GO:0014888) NEW6.680.034GATA6, GATA4
endoderm formation (GO:0001706) NEW7.090.01TBX20, GATA4
positive regulation of multicellular organismal process (GO:0051240) -2.490.048GATA6, TBX20, NKX2-5, GATA4
cardiac muscle hypertrophy (GO:0003300) NEW6.840.019GATA6, GATA4
heart looping (GO:0001947) -5.650.0CITED2, TBX20, MYH6, GATA4, NKX2-5
endocardial cushion development (GO:0003197) -7.330.004CITED2, GATA4
epithelial tube morphogenesis (GO:0060562) -5.120.0CITED2, TBX20, MYH6, GATA4, NKX2-5
positive regulation of cell proliferation (GO:0008284) -3.010.01GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
muscle cell development (GO:0055001) -5.290.003TBX20, MYH6, GATA4, NKX2-5
striated muscle cell development (GO:0055002) -5.420.002TBX20, MYH6, GATA4, NKX2-5
multicellular organismal process (GO:0032501) -1.450.02GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
tube morphogenesis (GO:0035239) -4.350.0GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
multicellular organismal reproductive process (GO:0048609) NEW3.350.04GATA6, GATA4, NKX2-5, CITED2, ACTC1, MYH6
cardiac cell development (GO:0055006) -6.330.0TBX20, MYH6, GATA4, NKX2-5
cardiac muscle cell differentiation (GO:0055007) -6.290.049GATA6, TBX20, NKX2-5, GATA4
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.0ACTC1, TBX20, GATA4, MYH6, NKX2-5
atrial cardiac muscle tissue morphogenesis (GO:0055009) NEW8.120.028TBX20, MYH6
sarcomere organization (GO:0045214) -6.40.043NKX2-5, MYH6
positive regulation of transcription, DNA-templated (GO:0045893) -2.560.034GATA6, TBX20, CITED2, GATA4, NKX2-5
cardiac vascular smooth muscle cell differentiation (GO:0060947) NEW8.630.002GATA6, MYH6
pancreatic A cell differentiation (GO:0003310) NEW8.630.003GATA6, GATA4
vascular smooth muscle cell differentiation (GO:0035886) NEW7.940.01GATA6, MYH6
positive regulation of developmental process (GO:0051094) -2.770.006GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
left/right pattern formation (GO:0060972) -7.530.006CITED2, NKX2-5
positive regulation of RNA biosynthetic process (GO:1902680) -2.540.04GATA6, TBX20, CITED2, GATA4, NKX2-5
cell migration involved in heart development (GO:0060973) NEW7.090.0TBX20, MYH6, GATA4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) -2.810.008GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
embryo development (GO:0009790) -4.20.022GATA6, TBX20, MYH6, GATA4, NKX2-5
developmental process (GO:0032502) -1.360.009GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
ventricular cardiac muscle cell development (GO:0055015) NEW7.330.0TBX20, NKX2-5, GATA4
heart development (GO:0007507) -4.240.027TBX20, GATA4, NKX2-5, CITED2, MYH6, TLL1
cardiac muscle cell development (GO:0055013) -6.40.0TBX20, MYH6, GATA4, NKX2-5
actomyosin structure organization (GO:0031032) -5.40.001ACTC1, NKX2-5, MYH6
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.0TBX20, MYH6, GATA4, NKX2-5
regulation of heart growth (GO:0060420) -5.970.0GATA6, TBX20, MYH6, GATA4, NKX2-5
actin cytoskeleton organization (GO:0030036) -4.10.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
negative regulation of cardiac muscle cell apoptotic process (GO:0010667) NEW7.160.028NKX2-5, GATA4
embryonic heart tube left/right pattern formation (GO:0060971) -8.340.001CITED2, NKX2-5
striated muscle tissue development (GO:0014706) -5.230.006GATA6, TBX20, NKX2-5, GATA4
negative regulation of striated muscle cell apoptotic process (GO:0010664) NEW6.90.049NKX2-5, GATA4
smooth muscle cell differentiation (GO:0051145) NEW6.680.005GATA6, MYH6, GATA4
regulation of muscle cell differentiation (GO:0051147) NEW4.680.013TBX20, MYH6, GATA4, NKX2-5
striated muscle cell differentiation (GO:0051146) -5.690.0GATA6, TBX20, NKX2-5, GATA4
muscle adaptation (GO:0043500) NEW6.430.049GATA6, GATA4
morphogenesis of an epithelium (GO:0002009) -4.080.001GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
growth (GO:0040007) NEW3.80.004GATA6, TBX20, GATA4, CITED2, MYH6, TLL1
regulation of growth (GO:0040008) -3.260.001GATA6, TBX20, MYH6, GATA4, NKX2-5
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) -2.60.044GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
regulation of transcription from RNA polymerase II promoter (GO:0006357) -2.240.005GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
tissue morphogenesis (GO:0048729) -3.870.0GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
spleen development (GO:0048536) -6.070.009CITED2, NKX2-5, GATA4
embryonic morphogenesis (GO:0048598) -3.720.006GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.0GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of cell migration (GO:0030334) NEW3.230.026GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
actin filament-based process (GO:0030029) -3.940.0GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
pattern specification process (GO:0007389) -3.790.008GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of organ growth (GO:0046620) -5.410.0GATA6, TBX20, MYH6, GATA4, NKX2-5
embryonic heart tube anterior/posterior pattern specification (GO:0035054) NEW8.630.001NKX2-5, GATA4
cardiocyte differentiation (GO:0035051) -6.020.0GATA6, TBX20, NKX2-5, GATA4
single-organism developmental process (GO:0044767) -1.490.004GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6, TLL1
regulation of male gonad development (GO:2000018) NEW7.530.0GATA6, CITED2, GATA4
response to estrogen (GO:0043627) -5.250.026GATA6, CITED2, GATA4
mesenchyme development (GO:0060485) -5.70.0NKX2-5, GATA6, CITED2, GATA4, MYH6
embryonic heart tube morphogenesis (GO:0003143) -5.570.0CITED2, TBX20, MYH6, GATA4, NKX2-5
cytoskeleton organization (GO:0007010) -3.220.033GATA6, TBX20, NKX2-5, GATA4, ACTC1, MYH6
cardiac septum development (GO:0003279) -5.940.005TBX20, NKX2-5, GATA4
outflow tract septum morphogenesis (GO:0003148) -7.090.0GATA6, TBX20, NKX2-5
anatomical structure development (GO:0048856) -1.580.006GATA6, TBX20, NKX2-5, GATA4, CITED2, MYH6, TLL1
positive regulation of male gonad development (GO:2000020) NEW7.650.035CITED2, GATA4
regulation of multicellular organismal development (GO:2000026) -2.310.003GATA6, TBX20, GATA4, NKX2-5, CITED2, MYH6
regulation of organ morphogenesis (GO:2000027) NEW4.220.001CITED2, TBX20, MYH6, GATA4, NKX2-5
muscle tissue development (GO:0060537) -5.10.011GATA6, TBX20, NKX2-5, GATA4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.287GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
intracellular organelle (GO:0043229) 0.517GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
cell part (GO:0044464) 0.117GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
organelle (GO:0043226) 0.47GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1, MYH6
intracellular organelle part (GO:0044446) 0.816GATA6, GATA4, NKX2-5, CITED2, ACTC1, MYH6
membrane-bounded organelle (GO:0043227) 0.476GATA6, TBX20, NKX2-5, GATA4, CITED2, ACTC1
organelle part (GO:0044422) 0.796GATA6, GATA4, NKX2-5, CITED2, ACTC1, MYH6
cytoplasm (GO:0005737) 1.015ACTC1, CITED2, TBX20, NKX2-5, MYH6
nucleus (GO:0005634) 1.075GATA6, TBX20, CITED2, GATA4, NKX2-5
macromolecular complex (GO:0032991) 1.355NKX2-5, GATA6, CITED2, GATA4, MYH6
intracellular membrane-bounded organelle (GO:0043231) 0.65GATA6, TBX20, CITED2, GATA4, NKX2-5
protein complex (GO:0043234) 1.514GATA6, MYH6, GATA4, NKX2-5
nuclear part (GO:0044428) 1.554GATA6, CITED2, GATA4, NKX2-5
transcription factor complex (GO:0005667) 4.13GATA6, NKX2-5, GATA4
intracellular non-membrane-bounded organelle (GO:0043232) 1.762ACTC1, MYH6
cytoplasmic part (GO:0044444) 0.822ACTC1, MYH6
cytosol (GO:0005829) 1.682ACTC1, MYH6
membrane (GO:0016020) 0.682TLL1, ACTC1
nuclear transcription factor complex (GO:0044798) 4.952NKX2-5, GATA4
nucleoplasm (GO:0005654) 1.892GATA6, GATA4
sarcomere (GO:0030017) 5.952ACTC1, MYH6
RNA polymerase II transcription factor complex (GO:0090575) 5.182NKX2-5, GATA4
non-membrane-bounded organelle (GO:0043228) 1.762ACTC1, MYH6
cytoskeletal part (GO:0044430) 2.492ACTC1, MYH6
contractile fiber part (GO:0044449) 4.532ACTC1, MYH6

NET-GE enrichment

Term New enriched termICP valueGenes
sarcomere (GO:0030017) -5.950.005ACTC1, MYH6