Disease table of TETRALOGY OF FALLOT OMIM ID: 187500

Gene-disease associations table

GeneAssociated with TETRALOGY OF FALLOT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ZFPM2ClinVar, OMIM, HUMSAVARHGNC link8q22.34187500, 610187, PS400044, 217095
GDF1ClinVar, OMIM, HUMSAVARHGNC link19p13.114187500, 208530, PS608808, 217095
TBX1ClinVar, OMIMHGNC link22q11.214187500, 188400, 192430, 217095
GATA6ClinVar, OMIM, HUMSAVARHGNC link18q11.25600001, PS108800, 217095, PS606215, 187500
GATA4ClinVar, OMIM, HUMSAVARHGNC link8p23.15PS614429, PS108800, 615542, PS606215, 187500
JAG1ClinVar, OMIM, HUMSAVARHGNC link20p12.22187500, PS118450
NKX2-5ClinVar, OMIM, HUMSAVARHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
82ZFPM2, GATA4
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
GATA6YES9DKK1, PLAU, CYP17A1, APOA1, CAV1, CYP11A1, VWF, SULT2A1, DAB20
GATA4YES22NKX2-5, FGF10, HDAC9, CYP17A1, NOS3, CCND2, BMP4, HESX1, HAMP, FCGR3B, STAR, ERBB2, FABP2, IAPP, NPPA, AMH, SUMO1, NPPB, IL5, SGPL1, FCGR2B, MEF2C1NKX2-5
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL11GATA4
NANOGNO23GATA4, GATA2, FGF4, CGB, GDF3, AFP, POU5F1, GATA6, CGA, KDR, LAMB1, L1TD1, MTF2, DKK1, CDC25A, SEMA6A, SOX1, YES1, LXN, CDK6, CDX2, CCND1, KLF22GATA6, GATA4
HEY1NO9GATA6, PROX1, ACTA2, GATA4, CCL2, BMP2, KDR, TNFRSF12A, OCLN2GATA6, GATA4
HEY2NO3GATA6, GATA4, ACTA22GATA6, GATA4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GATA6YES4HEY2, HEY1, NANOG, POU5F10
GATA4YES4HEY2, HEY1, NKX2-5, NANOG1NKX2-5
JAG1YES4RUNX3, KDM4C, PPARG, SNAI20
NKX2-5YES1GATA41GATA4
CYP17A1NO12SP1, NR5A1, PIAS1, GATA4, GATA6, NFIC, NR2F1, NR4A1, CREB1, NR0B1, SP3, SMAD32GATA6, GATA4
NPPBNO7XBP1, NKX2-5, GATA4, TEF, SHOX, RELA, NFKB12NKX2-5, GATA4
MEF2CNO5NKX2-5, GFI1B, GATA4, ISL1, HDAC72NKX2-5, GATA4
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ZFPM2GATA4Yes1HDAC2
ZFPM2NKX2-5No2HDAC1, GATA4
GATA6GATA4No2SP1, EP300
GATA6NKX2-5No1EWSR1
GATA4NKX2-5Yes7JARID2, FOXE1, ID3, TBX5, ID2, KDM6A, ID1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ZFPM2GATA6Yesbinding3GATA3, ZFPM1, GATA4
ZFPM2GATA4Yesactivation, binding5AMH, SRY, GATA6, ZFPM1, GATA3
ZFPM2NKX2-5No-1GATA4
GATA6GATA4Yesactivation, binding15SP1, ZFPM2, ZFPM1, NKX2-1, KLF13, HEY2, HEY1, STAR, CYP17A1, CDK9, MYOCD, SMAD2, BMP2, GATA3, EP300
GATA6JAG1No-1SHH
GATA6NKX2-5No-5BMP2, CALR, MYOCD, SMAD2, GATA4
GATA4NKX2-5Yesactivation, binding29BMPR1A, BMP4, SMAD4, ATF2, BMP7, BMP5, SRF, SUMO1, SMAD6, MAP3K7, SMAD3, HAND2, SMARCD3, SMAD5, CHRD, BMPR2, MEF2A, SMAD2, ID2, NFATC1, NOG, JARID2, BCL2, MYL2, TBX5, BMP10, MYOCD, BMP2, MEF2C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
GATA4NKX2-5yes, they interact but maybe not in complexGATA4 acts as a transcriptional activator of ANF in cooperation with NKX2-5. [UniProt]
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
MicroRNAs in cancer (hsa05206) NEW5.380.046GATA6, ZFPM2, GATA4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.883GATA6, ZFPM2, GATA4
HemostasisR-HSA-1095823.983GATA6, ZFPM2, GATA4
Generic Transcription PathwayR-HSA-2124363.862NKX2-5, GATA4
Gene ExpressionR-HSA-741602.722NKX2-5, GATA4
YAP1- and WWTR1 (TAZ)-stimulated gene expressionR-HSA-20327858.122NKX2-5, GATA4

NET-GE enrichment

Term New enriched termICP valueGenes
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) -5.880.003GATA6, ZFPM2, GATA4
Developmental Biology (R-HSA-1266738) NEW3.480.022GDF1, GATA4, NKX2-5, JAG1, GATA6, TBX1
YAP1- and WWTR1 (TAZ)-stimulated gene expression (R-HSA-2032785) -8.120.006NKX2-5, GATA4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
protein binding (GO:0005515) 0.467JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.655GATA6, TBX1, ZFPM2, GATA4, NKX2-5
organic cyclic compound binding (GO:0097159) 1.055ZFPM2, TBX1, GATA6, GATA4, NKX2-5
nucleic acid binding transcription factor activity (GO:0001071) 2.655GATA6, TBX1, ZFPM2, GATA4, NKX2-5
nucleic acid binding (GO:0003676) 1.445GATA6, TBX1, ZFPM2, GATA4, NKX2-5
DNA binding (GO:0003677) 1.925GATA6, TBX1, ZFPM2, GATA4, NKX2-5
heterocyclic compound binding (GO:1901363) 1.065ZFPM2, TBX1, GATA6, GATA4, NKX2-5
sequence-specific DNA binding (GO:0043565) 2.794GATA6, TBX1, GATA4, NKX2-5
cation binding (GO:0043169) 1.44ZFPM2, GATA6, GATA4, JAG1
transcription factor binding (GO:0008134) 3.464ZFPM2, GATA6, GATA4, NKX2-5
ion binding (GO:0043167) 1.364GATA6, ZFPM2, GATA4, JAG1
metal ion binding (GO:0046872) 1.414GATA6, ZFPM2, GATA4, JAG1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.294ZFPM2, GATA6, GATA4, NKX2-5
RNA polymerase II transcription factor binding (GO:0001085) 5.083ZFPM2, GATA6, GATA4
transcription regulatory region DNA binding (GO:0044212) 3.033GATA6, NKX2-5, GATA4
sequence-specific double-stranded DNA binding (GO:1990837) 3.23GATA6, NKX2-5, GATA4
transition metal ion binding (GO:0046914) 2.483GATA6, ZFPM2, GATA4
regulatory region nucleic acid binding (GO:0001067) 3.033GATA6, NKX2-5, GATA4
regulatory region DNA binding (GO:0000975) 3.033GATA6, NKX2-5, GATA4
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.363GATA6, NKX2-5, GATA4
transcription cofactor activity (GO:0003712) 3.443ZFPM2, NKX2-5, GATA4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.983GATA6, NKX2-5, GATA4
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076) 4.843ZFPM2, NKX2-5, GATA4
macromolecular complex binding (GO:0044877) 2.613GATA6, NKX2-5, GATA4
zinc ion binding (GO:0008270) 2.663GATA6, ZFPM2, GATA4
transcription factor activity, transcription factor binding (GO:0000989) 3.363ZFPM2, NKX2-5, GATA4
transcription factor activity, protein binding (GO:0000988) 3.353ZFPM2, NKX2-5, GATA4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.243GATA6, NKX2-5, GATA4
double-stranded DNA binding (GO:0003690) 3.093GATA6, NKX2-5, GATA4
chromatin binding (GO:0003682) 3.643GATA6, NKX2-5, GATA4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.373GATA6, NKX2-5, GATA4
RNA polymerase II transcription cofactor activity (GO:0001104) 5.222ZFPM2, NKX2-5
transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) 5.282ZFPM2, NKX2-5
transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190) 5.772ZFPM2, NKX2-5
growth factor activity (GO:0008083) 4.662GDF1, JAG1
receptor binding (GO:0005102) 2.432GDF1, JAG1
transcriptional repressor activity, RNA polymerase II activating transcription factor binding (GO:0098811) 5.772ZFPM2, NKX2-5
transcription coactivator activity (GO:0003713) 4.042ZFPM2, GATA4
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232GATA6, NKX2-5
enzyme binding (GO:0019899) 2.272GATA6, GATA4
protein kinase binding (GO:0019901) 3.442GATA6, GATA4
kinase binding (GO:0019900) 3.322GATA6, GATA4
protein dimerization activity (GO:0046983) 2.722TBX1, NKX2-5
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942ZFPM2, NKX2-5
identical protein binding (GO:0042802) 2.632TBX1, NKX2-5
protein homodimerization activity (GO:0042803) 3.162TBX1, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
RNA polymerase II transcription factor binding (GO:0001085) -5.080.011GATA6, NKX2-5, GATA4
sequence-specific DNA binding (GO:0043565) -2.790.007GATA6, TBX1, ZFPM2, GATA4, NKX2-5
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190) -5.770.006ZFPM2, NKX2-5
transcription regulatory region DNA binding (GO:0044212) -3.030.042GATA6, NKX2-5, GATA4
regulatory region nucleic acid binding (GO:0001067) -3.030.044GATA6, NKX2-5, GATA4
transcription factor binding (GO:0008134) -3.460.005GATA6, TBX1, ZFPM2, GATA4, NKX2-5
transcription corepressor activity (GO:0003714) NEW4.330.008ZFPM2, TBX1, GATA4, NKX2-5
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.026GATA6, TBX1, GATA4, NKX2-5
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) -5.230.0GATA6, TBX1, GATA4, NKX2-5
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.008GATA6, TBX1, GATA4, NKX2-5
RNA polymerase II transcription cofactor activity (GO:0001104) -5.220.006ZFPM2, NKX2-5, GATA4
RNA polymerase II transcription coactivator activity (GO:0001105) NEW6.150.028ZFPM2, NKX2-5
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) -4.840.025ZFPM2, NKX2-5, GATA4
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.042GATA6, TBX1, GATA4, NKX2-5
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.025GATA6, TBX1, GATA4, NKX2-5
regulatory region DNA binding (GO:0000975) -3.030.044GATA6, NKX2-5, GATA4
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001205) NEW6.480.041TBX1, GATA4
chromatin binding (GO:0003682) -3.640.026GATA6, TBX1, ZFPM2, GATA4, NKX2-5
transcription cofactor activity (GO:0003712) -3.440.047ZFPM2, NKX2-5, GATA4
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.023GATA6, NKX2-5, GATA4
nucleic acid binding transcription factor activity (GO:0001071) -2.650.03GATA6, ZFPM2, GATA4, NKX2-5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of RNA metabolic process (GO:0051252) 1.527JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
positive regulation of metabolic process (GO:0009893) 1.747JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of metabolic process (GO:0019222) 1.027JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of cellular biosynthetic process (GO:0031326) 1.387JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
positive regulation of cellular metabolic process (GO:0031325) 1.817JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of cellular metabolic process (GO:0031323) 1.077JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of biological process (GO:0050789) 0.457JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
single-organism process (GO:0044699) 0.487JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of primary metabolic process (GO:0080090) 1.087JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
positive regulation of macromolecule metabolic process (GO:0010604) 1.817JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
cellular developmental process (GO:0048869) 1.827JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.467JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of macromolecule metabolic process (GO:0060255) 1.087JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of macromolecule biosynthetic process (GO:0010556) 1.437JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
biological regulation (GO:0065007) 0.397JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
positive regulation of biological process (GO:0048518) 1.27JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of gene expression (GO:0010468) 1.377JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
developmental process (GO:0032502) 1.367JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.437JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
cellular process (GO:0009987) 0.267JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of biosynthetic process (GO:0009889) 1.377JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of nucleic acid-templated transcription (GO:1903506) 1.557JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of cellular process (GO:0050794) 0.57JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
single-organism developmental process (GO:0044767) 1.497JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
single-organism cellular process (GO:0044763) 0.657JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of nitrogen compound metabolic process (GO:0051171) 1.367JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of RNA biosynthetic process (GO:2001141) 1.557JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
anatomical structure development (GO:0048856) 1.587JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of transcription, DNA-templated (GO:0006355) 1.567JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.247JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
positive regulation of cellular process (GO:0048522) 1.37JAG1, GDF1, NKX2-5, GATA4, ZFPM2, TBX1, GATA6
metabolic process (GO:0008152) 0.586ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of biosynthetic process (GO:0009891) 2.296ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cell differentiation (GO:0030154) 2.146ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of response to stimulus (GO:0048583) 1.546GDF1, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of gene expression (GO:0010628) 2.356ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of signaling (GO:0023051) 1.726GDF1, GATA4, NKX2-5, JAG1, GATA6, TBX1
anatomical structure morphogenesis (GO:0009653) 2.536ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cell communication (GO:0010646) 1.736GDF1, GATA4, NKX2-5, JAG1, GATA6, TBX1
cellular macromolecule metabolic process (GO:0044260) 0.936ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of signal transduction (GO:0009966) 1.846GDF1, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of multicellular organismal process (GO:0051240) 2.496ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of cellular biosynthetic process (GO:0031328) 2.36ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
organic substance metabolic process (GO:0071704) 0.636ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
animal organ development (GO:0048513) 2.536ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
negative regulation of biological process (GO:0048519) 1.336ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.566ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
multicellular organismal process (GO:0032501) 1.456ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.356ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of developmental process (GO:0050793) 2.16ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
tissue development (GO:0009888) 3.276ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cell differentiation (GO:0045595) 2.426ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of transcription, DNA-templated (GO:0045893) 2.566ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of multicellular organismal process (GO:0051239) 1.876ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.296ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.816ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
primary metabolic process (GO:0044238) 0.696ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
single-multicellular organism process (GO:0044707) 1.786ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of developmental process (GO:0051094) 2.776ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of RNA metabolic process (GO:0051254) 2.516ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cellular metabolic process (GO:0044237) 0.696ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
macromolecule metabolic process (GO:0043170) 0.836ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of RNA biosynthetic process (GO:1902680) 2.546ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.396ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of multicellular organismal development (GO:2000026) 2.316ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cardiac septum morphogenesis (GO:0060411) 5.96ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
negative regulation of cellular process (GO:0048523) 1.416ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
RNA biosynthetic process (GO:0032774) 1.845GATA6, TBX1, ZFPM2, GATA4, NKX2-5
positive regulation of response to stimulus (GO:0048584) 2.185TBX1, GATA6, GDF1, JAG1, GATA4
cell development (GO:0048468) 3.285NKX2-5, GATA6, GDF1, GATA4, JAG1
positive regulation of signaling (GO:0023056) 2.415GATA6, GDF1, TBX1, GATA4, JAG1
cellular biosynthetic process (GO:0044249) 1.375ZFPM2, TBX1, GATA6, GATA4, NKX2-5
cellular nitrogen compound metabolic process (GO:0034641) 1.225GATA6, TBX1, ZFPM2, GATA4, NKX2-5
nitrogen compound metabolic process (GO:0006807) 1.135ZFPM2, TBX1, GATA6, GATA4, NKX2-5
cellular macromolecule biosynthetic process (GO:0034645) 1.665GATA6, TBX1, ZFPM2, GATA4, NKX2-5
positive regulation of cell communication (GO:0010647) 2.415JAG1, GATA6, GDF1, TBX1, GATA4
regulation of cell death (GO:0010941) 2.435GATA6, GDF1, ZFPM2, TBX1, NKX2-5
organic cyclic compound biosynthetic process (GO:1901362) 1.665ZFPM2, TBX1, GATA6, GATA4, NKX2-5
multicellular organism development (GO:0007275) 2.545NKX2-5, GATA6, ZFPM2, TBX1, JAG1
nucleic acid-templated transcription (GO:0097659) 1.915GATA6, TBX1, ZFPM2, GATA4, NKX2-5
nucleobase-containing compound metabolic process (GO:0006139) 1.355GATA6, TBX1, ZFPM2, GATA4, NKX2-5
positive regulation of signal transduction (GO:0009967) 2.55JAG1, GATA6, GDF1, TBX1, GATA4
organic cyclic compound metabolic process (GO:1901360) 1.265GATA6, TBX1, ZFPM2, GATA4, NKX2-5
tissue morphogenesis (GO:0048729) 3.875NKX2-5, ZFPM2, TBX1, GATA4, JAG1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.015NKX2-5, GATA6, TBX1, GATA4, JAG1
heterocycle biosynthetic process (GO:0018130) 1.75ZFPM2, TBX1, GATA6, GATA4, NKX2-5
organic substance biosynthetic process (GO:1901576) 1.345GATA6, TBX1, ZFPM2, GATA4, NKX2-5
cellular aromatic compound metabolic process (GO:0006725) 1.35GATA6, TBX1, ZFPM2, GATA4, NKX2-5
positive regulation of cell differentiation (GO:0045597) 3.015NKX2-5, GATA6, TBX1, GATA4, JAG1
biosynthetic process (GO:0009058) 1.325GATA6, TBX1, ZFPM2, GATA4, NKX2-5
macromolecule biosynthetic process (GO:0009059) 1.615ZFPM2, TBX1, GATA6, GATA4, NKX2-5
nucleobase-containing compound biosynthetic process (GO:0034654) 1.725ZFPM2, TBX1, GATA6, GATA4, NKX2-5
heterocycle metabolic process (GO:0046483) 1.315ZFPM2, TBX1, GATA6, GATA4, NKX2-5
RNA metabolic process (GO:0016070) 1.595GATA6, TBX1, ZFPM2, GATA4, NKX2-5
nucleic acid metabolic process (GO:0090304) 1.465ZFPM2, TBX1, GATA6, GATA4, NKX2-5
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595ZFPM2, TBX1, GATA6, GATA4, NKX2-5
transcription, DNA-templated (GO:0006351) 1.915ZFPM2, TBX1, GATA6, GATA4, NKX2-5
aromatic compound biosynthetic process (GO:0019438) 1.75ZFPM2, TBX1, GATA6, GATA4, NKX2-5
regulation of cell proliferation (GO:0042127) 2.414GATA6, TBX1, NKX2-5, JAG1
outflow tract septum morphogenesis (GO:0003148) 7.094ZFPM2, GATA6, TBX1, NKX2-5
cell fate commitment (GO:0045165) 4.724GATA6, TBX1, GATA4, NKX2-5
tube morphogenesis (GO:0035239) 4.354GATA6, TBX1, GATA4, NKX2-5
negative regulation of cell death (GO:0060548) 2.954ZFPM2, GATA6, TBX1, NKX2-5
response to stimulus (GO:0050896) 1.224GATA6, TBX1, JAG1, GATA4
negative regulation of cell differentiation (GO:0045596) 3.334TBX1, ZFPM2, NKX2-5, JAG1
regulation of programmed cell death (GO:0043067) 2.494GATA6, GDF1, TBX1, NKX2-5
signal transduction (GO:0007165) 1.284TBX1, GDF1, NKX2-5, JAG1
epithelial cell differentiation (GO:0030855) 3.984GATA6, TBX1, JAG1, GATA4
response to chemical (GO:0042221) 1.984GATA6, TBX1, JAG1, GATA4
muscle cell differentiation (GO:0042692) 5.094GATA6, JAG1, GATA4, NKX2-5
regulation of apoptotic process (GO:0042981) 2.54GATA6, GDF1, TBX1, NKX2-5
response to organic substance (GO:0010033) 2.24GATA6, TBX1, GATA4, JAG1
regulation of stem cell differentiation (GO:2000736) 6.264GATA6, JAG1, GATA4, NKX2-5
regulation of muscle tissue development (GO:1901861) 5.073GATA6, TBX1, NKX2-5
negative regulation of metabolic process (GO:0009892) 1.933ZFPM2, GATA6, NKX2-5
cellular response to chemical stimulus (GO:0070887) 2.573GATA6, TBX1, GATA4
negative regulation of biosynthetic process (GO:0009890) 2.473ZFPM2, GATA6, NKX2-5
regulation of anatomical structure morphogenesis (GO:0022603) 2.793GATA6, TBX1, GATA4
negative regulation of cellular biosynthetic process (GO:0031327) 2.493GATA6, ZFPM2, NKX2-5
positive regulation of stem cell differentiation (GO:2000738) 7.023GATA6, NKX2-5, GATA4
blood coagulation (GO:0007596) 4.523GATA6, ZFPM2, GATA4
regulation of muscle organ development (GO:0048634) 5.073GATA6, TBX1, NKX2-5
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63GATA6, ZFPM2, NKX2-5
positive regulation of cell proliferation (GO:0008284) 3.013GATA6, TBX1, NKX2-5
negative regulation of gene expression (GO:0010629) 2.483ZFPM2, GATA6, NKX2-5
cell surface receptor signaling pathway (GO:0007166) 2.093GDF1, JAG1, NKX2-5
striated muscle cell differentiation (GO:0051146) 5.693GATA6, NKX2-5, GATA4
hemostasis (GO:0007599) 4.53GATA6, ZFPM2, GATA4
positive regulation of cardioblast differentiation (GO:0051891) 8.123GATA6, NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) 7.783GATA6, NKX2-5, GATA4
response to endogenous stimulus (GO:0009719) 2.793GATA6, JAG1, TBX1
pattern specification process (GO:0007389) 3.793TBX1, NKX2-5, GATA4
cellular response to stimulus (GO:0051716) 1.973GATA6, TBX1, GATA4
cardiac chamber morphogenesis (GO:0003206) 6.363JAG1, NKX2-5, GATA4
negative regulation of macromolecule metabolic process (GO:0010605) 2.013ZFPM2, GATA6, NKX2-5
regulation of body fluid levels (GO:0050878) 3.763GATA6, ZFPM2, GATA4
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.123GATA6, GDF1, GATA4
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123GATA6, ZFPM2, NKX2-5
negative regulation of multicellular organismal process (GO:0051241) 2.843GATA6, ZFPM2, JAG1
cardiac ventricle morphogenesis (GO:0003208) 6.553JAG1, NKX2-5, GATA4
negative regulation of developmental process (GO:0051093) 3.173ZFPM2, JAG1, NKX2-5
cellular response to organic substance (GO:0071310) 2.783GATA6, TBX1, GATA4
negative regulation of apoptotic process (GO:0043066) 3.043GATA6, TBX1, NKX2-5
transcription from RNA polymerase II promoter (GO:0006366) 3.383GATA6, NKX2-5, GATA4
hematopoietic or lymphoid organ development (GO:0048534) 4.493TBX1, JAG1, NKX2-5
regulation of biological quality (GO:0065008) 1.683GATA6, ZFPM2, GATA4
negative regulation of programmed cell death (GO:0043069) 3.023GATA6, TBX1, NKX2-5
columnar/cuboidal epithelial cell differentiation (GO:0002065) 5.843GATA6, JAG1, GATA4
embryonic morphogenesis (GO:0048598) 3.723TBX1, NKX2-5, GATA4
regulation of striated muscle tissue development (GO:0016202) 5.093GATA6, TBX1, NKX2-5
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.393GATA6, GDF1, GATA4
negative regulation of cellular metabolic process (GO:0031324) 2.013GATA6, ZFPM2, NKX2-5
reproductive structure development (GO:0048608) 4.083ZFPM2, GATA6, GATA4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553ZFPM2, GATA6, NKX2-5
(GO:1905207) 6.43GATA6, NKX2-5, GATA4
cardiac muscle cell differentiation (GO:0055007) 6.293GATA6, NKX2-5, GATA4
(GO:1905209) 6.733GATA6, NKX2-5, GATA4
cardiocyte differentiation (GO:0035051) 6.023GATA6, NKX2-5, GATA4
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713ZFPM2, GATA6, NKX2-5
negative regulation of RNA biosynthetic process (GO:1902679) 2.73GATA6, ZFPM2, NKX2-5
reproductive process (GO:0022414) 2.553GATA6, ZFPM2, GATA4
coagulation (GO:0050817) 4.513ZFPM2, GATA6, GATA4
negative regulation of transcription, DNA-templated (GO:0045892) 2.753ZFPM2, GATA6, NKX2-5
regionalization (GO:0003002) 4.243TBX1, NKX2-5, GATA4
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473ZFPM2, GATA6, NKX2-5
organ morphogenesis (GO:0009887) 3.553TBX1, JAG1, NKX2-5
mesenchyme development (GO:0060485) 5.73ZFPM2, NKX2-5, GATA4
regulation of localization (GO:0032879) 1.943JAG1, NKX2-5, GATA4
system process (GO:0003008) 2.33GATA6, TBX1, NKX2-5
response to oxygen-containing compound (GO:1901700) 2.573TBX1, JAG1, GATA4
heart development (GO:0007507) 4.243ZFPM2, TBX1, NKX2-5
developmental process involved in reproduction (GO:0003006) 3.363ZFPM2, GATA6, GATA4
negative regulation of RNA metabolic process (GO:0051253) 2.663ZFPM2, GATA6, NKX2-5
striated muscle tissue development (GO:0014706) 5.233ZFPM2, GATA6, NKX2-5
cardiac muscle tissue development (GO:0048738) 6.333ZFPM2, GATA6, NKX2-5
muscle tissue development (GO:0060537) 5.13ZFPM2, GATA6, NKX2-5
system development (GO:0048731) 2.923TBX1, JAG1, NKX2-5
gland development (GO:0048732) 4.153GATA6, TBX1, NKX2-5
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533ZFPM2, GATA6, NKX2-5
muscle tissue morphogenesis (GO:0060415) 5.623ZFPM2, TBX1, NKX2-5
morphogenesis of an epithelium (GO:0002009) 4.083JAG1, NKX2-5, GATA4
regulation of phosphate metabolic process (GO:0019220) 2.352GDF1, TBX1
male gonad development (GO:0008584) 5.082GATA6, GATA4
BMP signaling pathway (GO:0030509) 5.332GDF1, NKX2-5
muscle system process (GO:0003012) 4.182GATA6, NKX2-5
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242GDF1, NKX2-5
outflow tract morphogenesis (GO:0003151) 5.972TBX1, NKX2-5
response to growth factor (GO:0070848) 4.142GATA6, TBX1
regulation of neuron differentiation (GO:0045664) 3.392JAG1, NKX2-5
blood vessel morphogenesis (GO:0048514) 5.322TBX1, JAG1
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62GDF1, NKX2-5
regulation of muscle contraction (GO:0006937) 4.752NKX2-5, GATA4
heart morphogenesis (GO:0003007) 5.842TBX1, NKX2-5
cardiac right ventricle morphogenesis (GO:0003215) 7.432JAG1, GATA4
positive regulation of BMP signaling pathway (GO:0030513) 6.262GATA6, GATA4
regulation of cardiac muscle contraction (GO:0055117) 5.572NKX2-5, GATA4
regulation of BMP signaling pathway (GO:0030510) 5.362GATA6, GATA4
regulation of phosphorylation (GO:0042325) 2.52GDF1, TBX1
positive regulation of phosphorylation (GO:0042327) 2.92GDF1, TBX1
single organism reproductive process (GO:0044702) 2.732GATA6, GATA4
protein metabolic process (GO:0019538) 1.452GATA6, JAG1
embryo development ending in birth or egg hatching (GO:0009792) 4.352ZFPM2, GATA6
atrial septum morphogenesis (GO:0060413) 7.092NKX2-5, GATA4
ventricular septum morphogenesis (GO:0060412) 6.592ZFPM2, NKX2-5
muscle cell fate commitment (GO:0042693) 7.332TBX1, NKX2-5
intestinal epithelial cell differentiation (GO:0060575) 7.942GATA6, GATA4
positive regulation of striated muscle tissue development (GO:0045844) 5.692GATA6, TBX1
regulation of vasculature development (GO:1901342) 4.262GATA6, GATA4
cellular protein metabolic process (GO:0044267) 1.632GATA6, JAG1
gonad development (GO:0008406) 4.922GATA6, GATA4
thyroid gland development (GO:0030878) 6.472TBX1, NKX2-5
positive regulation of muscle tissue development (GO:1901863) 5.672GATA6, TBX1
regulation of cardiac muscle tissue development (GO:0055024) 5.862GATA6, NKX2-5
regulation of heart contraction (GO:0008016) 4.352NKX2-5, GATA4
regulation of cardiac muscle tissue growth (GO:0055021) 6.122GATA6, NKX2-5
programmed cell death (GO:0012501) 3.12TBX1, NKX2-5
positive regulation of vasculature development (GO:1904018) 4.832GATA6, GATA4
regulation of blood circulation (GO:1903522) 4.052NKX2-5, GATA4
regulation of intracellular signal transduction (GO:1902531) 2.312GDF1, TBX1
vasculogenesis (GO:0001570) 5.652ZFPM2, NKX2-5
anterior/posterior pattern specification (GO:0009952) 4.712TBX1, GATA4
positive regulation of protein modification process (GO:0031401) 2.72GDF1, TBX1
regulation of nervous system development (GO:0051960) 3.12JAG1, NKX2-5
aorta morphogenesis (GO:0035909) 6.842TBX1, JAG1
regulation of developmental growth (GO:0048638) 4.042GATA6, NKX2-5
mesoderm development (GO:0007498) 5.722ZFPM2, TBX1
positive regulation of muscle organ development (GO:0048636) 5.692GATA6, TBX1
embryo development (GO:0009790) 4.22ZFPM2, GATA6
regulation of striated muscle contraction (GO:0006942) 5.382NKX2-5, GATA4
regulation of cardiac muscle cell proliferation (GO:0060043) 6.332GATA6, NKX2-5
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) 9.042ZFPM2, NKX2-5
regulation of MAPK cascade (GO:0043408) 3.222GDF1, TBX1
regulation of neurogenesis (GO:0050767) 3.212JAG1, NKX2-5
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292GATA6, GATA4
in utero embryonic development (GO:0001701) 4.42GATA6, ZFPM2
regulation of system process (GO:0044057) 3.532NKX2-5, GATA4
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GDF1, TBX1
cell fate determination (GO:0001709) 5.972GATA6, JAG1
regulation of protein metabolic process (GO:0051246) 1.932GDF1, TBX1
positive regulation of protein metabolic process (GO:0051247) 2.432GDF1, TBX1
regulation of cell development (GO:0060284) 3.012JAG1, NKX2-5
heart looping (GO:0001947) 5.652NKX2-5, GATA4
positive regulation of cellular protein metabolic process (GO:0032270) 2.492GDF1, TBX1
regulation of protein modification process (GO:0031399) 2.322GDF1, TBX1
epithelial tube morphogenesis (GO:0060562) 5.122NKX2-5, GATA4
chordate embryonic development (GO:0043009) 4.382ZFPM2, GATA6
cellular response to endogenous stimulus (GO:0071495) 3.332GATA6, TBX1
regulation of heart growth (GO:0060420) 5.972GATA6, NKX2-5
cardiac cell development (GO:0055006) 6.332JAG1, NKX2-5
cellular response to oxygen-containing compound (GO:1901701) 3.222TBX1, GATA4
cardiac muscle tissue morphogenesis (GO:0055008) 5.82ZFPM2, NKX2-5
epithelium development (GO:0060429) 4.572JAG1, NKX2-5
regulation of striated muscle cell differentiation (GO:0051153) 5.262TBX1, NKX2-5
regulation of myotube differentiation (GO:0010830) 5.692TBX1, NKX2-5
negative regulation of fat cell differentiation (GO:0045599) 5.992ZFPM2, JAG1
regulation of fat cell differentiation (GO:0045598) 5.042ZFPM2, JAG1
regulation of cellular protein metabolic process (GO:0032268) 1.992GDF1, TBX1
cellular response to growth factor stimulus (GO:0071363) 4.272GATA6, TBX1
response to drug (GO:0042493) 3.712GATA6, GATA4
regulation of cytokine production (GO:0001817) 3.42GATA6, GATA4
hemopoiesis (GO:0030097) 5.072JAG1, NKX2-5
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.072ZFPM2, NKX2-5
regulation of muscle cell differentiation (GO:0051147) 4.682TBX1, NKX2-5
cell death (GO:0008219) 3.052TBX1, NKX2-5
angiogenesis (GO:0001525) 4.152TBX1, JAG1
response to lipid (GO:0033993) 3.112TBX1, GATA4
regulation of growth (GO:0040008) 3.262GATA6, NKX2-5
cell proliferation (GO:0008283) 3.232TBX1, NKX2-5
regulation of angiogenesis (GO:0045765) 4.362GATA6, GATA4
positive regulation of angiogenesis (GO:0045766) 4.932GATA6, GATA4
positive regulation of phosphate metabolic process (GO:0045937) 2.782GDF1, TBX1
regulation of organ growth (GO:0046620) 5.412GATA6, NKX2-5
pharyngeal system development (GO:0060037) 6.962TBX1, NKX2-5
apoptotic process (GO:0006915) 3.142TBX1, NKX2-5
regulation of phosphorus metabolic process (GO:0051174) 2.352GDF1, TBX1
regulation of muscle system process (GO:0090257) 4.512NKX2-5, GATA4
cell communication (GO:0007154) 3.042JAG1, GATA4
tube development (GO:0035295) 4.412JAG1, NKX2-5
response to abiotic stimulus (GO:0009628) 2.82GATA6, GATA4
regulation of cellular component movement (GO:0051270) 3.082JAG1, GATA4
cardiac septum development (GO:0003279) 5.942NKX2-5, GATA4
positive regulation of protein phosphorylation (GO:0001934) 2.952GDF1, TBX1
embryonic heart tube morphogenesis (GO:0003143) 5.572NKX2-5, GATA4
regulation of protein phosphorylation (GO:0001932) 2.572GDF1, TBX1
artery morphogenesis (GO:0048844) 5.882TBX1, JAG1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of stem cell differentiation (GO:2000736) -6.260.002GATA6, JAG1, GATA4, NKX2-5
negative regulation of reproductive process (GO:2000242) NEW5.760.006GATA6, ZFPM2, GATA4
positive regulation of stem cell differentiation (GO:2000738) -7.020.0GATA6, NKX2-5, GATA4
skeletal system development (GO:0001501) NEW4.490.043GATA6, JAG1, GATA4, NKX2-5
muscle system process (GO:0003012) -4.180.047GATA6, NKX2-5, GATA4
positive regulation of cardioblast differentiation (GO:0051891) -8.120.0GATA6, NKX2-5, GATA4
regulation of cardioblast differentiation (GO:0051890) -7.780.0GATA6, NKX2-5, GATA4
outflow tract morphogenesis (GO:0003151) -5.970.0GATA6, TBX1, GATA4, NKX2-5
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.012ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cellular developmental process (GO:0048869) -1.820.018ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
organ development (GO:0048513) -2.530.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
blood vessel morphogenesis (GO:0048514) -5.320.002TBX1, JAG1, GATA4, NKX2-5
epithelial cell differentiation (GO:0030855) -3.980.002GATA6, TBX1, JAG1, GATA4
response to gonadotropin (GO:0034698) NEW6.40.028GATA6, GATA4
regulation of cell proliferation (GO:0042127) -2.410.026GATA6, TBX1, JAG1, GATA4, NKX2-5
regulation of striated muscle tissue development (GO:0016202) -5.090.009GATA6, TBX1, GATA4, NKX2-5
muscle hypertrophy in response to stress (GO:0003299) NEW7.330.008GATA6, GATA4
negative regulation of cell death (GO:0060548) -2.950.032ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
heart morphogenesis (GO:0003007) -5.840.01TBX1, NKX2-5, GATA4
cardiac right ventricle morphogenesis (GO:0003215) -7.430.0GATA6, JAG1, GATA4
cardiac ventricle formation (GO:0003211) NEW7.430.034NKX2-5, GATA4
atrial septum morphogenesis (GO:0060413) -7.090.006NKX2-5, GATA4
ventricular septum morphogenesis (GO:0060412) -6.590.015ZFPM2, NKX2-5, GATA4
cardiac septum morphogenesis (GO:0060411) -5.90.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
muscle cell differentiation (GO:0042692) -5.090.007GATA6, JAG1, GATA4, NKX2-5
muscle tissue morphogenesis (GO:0060415) -5.620.001ZFPM2, TBX1, GATA4, NKX2-5
intestinal epithelial cell differentiation (GO:0060575) -7.940.005GATA6, GATA4
positive regulation of metabolic process (GO:0009893) -1.740.022ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of biosynthetic process (GO:0009891) -2.290.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
atrial septum development (GO:0003283) NEW7.780.007NKX2-5, GATA4
heart valve morphogenesis (GO:0003179) NEW6.550.026JAG1, GATA4
positive regulation of gene expression (GO:0010628) -2.350.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
embryonic axis specification (GO:0000578) NEW6.360.002GATA6, NKX2-5, GATA4
negative regulation of transcription by transcription factor localization (GO:0010621) NEW8.630.002GATA6, NKX2-5
positive regulation of RNA biosynthetic process (GO:1902680) -2.540.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cardiac chamber formation (GO:0003207) NEW7.330.041NKX2-5, GATA4
regulation of male gonad development (GO:2000018) NEW7.530.0ZFPM2, GATA6, GATA4
anterior/posterior axis specification (GO:0009948) NEW6.170.005GATA6, NKX2-5, GATA4
cardiac ventricle morphogenesis (GO:0003208) -6.550.022GATA6, JAG1, GATA4
thyroid gland development (GO:0030878) -6.470.014TBX1, NKX2-5
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.001GATA6, TBX1, JAG1, GATA4, NKX2-5
regulation of muscle tissue development (GO:1901861) -5.070.009GATA6, TBX1, GATA4, NKX2-5
embryonic pattern specification (GO:0009880) NEW5.80.022GATA6, NKX2-5, GATA4
regulation of developmental process (GO:0050793) -2.10.003ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cardiac muscle tissue development (GO:0055024) -5.860.026GATA6, NKX2-5, GATA4
tissue development (GO:0009888) -3.270.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.0GATA6, NKX2-5, GATA4
striated muscle adaptation (GO:0014888) NEW6.680.024GATA6, GATA4
regulation of multicellular organismal process (GO:0051239) -1.870.01ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of intracellular signal transduction (GO:1902533) NEW2.950.023ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of ossification (GO:0030278) NEW4.530.04GATA6, JAG1, GATA4, NKX2-5
muscle cell fate commitment (GO:0042693) -7.330.004TBX1, NKX2-5
vasculogenesis (GO:0001570) -5.650.001GATA6, ZFPM2, GATA4, NKX2-5
cell fate commitment (GO:0045165) -4.720.012GATA6, TBX1, GATA4, NKX2-5
anterior/posterior pattern specification (GO:0009952) -4.710.025GATA6, TBX1, GATA4, NKX2-5
positive regulation of macromolecule biosynthetic process (GO:0010557) -2.390.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
striated muscle hypertrophy (GO:0014897) NEW6.780.015GATA6, GATA4
aorta morphogenesis (GO:0035909) -6.840.012TBX1, JAG1
cardiac muscle hypertrophy in response to stress (GO:0014898) NEW7.330.008GATA6, GATA4
regulation of developmental growth (GO:0048638) -4.040.009GATA6, NKX2-5, GATA4
mesoderm development (GO:0007498) -5.720.0ZFPM2, TBX1, GATA4, NKX2-5
cardiac muscle adaptation (GO:0014887) NEW7.330.008GATA6, GATA4
cell differentiation (GO:0030154) -2.140.002ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of muscle organ development (GO:0048634) -5.070.0GATA6, TBX1, GATA4, NKX2-5
positive regulation of cardiac muscle cell proliferation (GO:0060045) NEW6.780.019GATA6, GATA4
embryo development ending in birth or egg hatching (GO:0009792) -4.350.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.0GATA6, NKX2-5, GATA4
anatomical structure morphogenesis (GO:0009653) -2.530.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
ventricular trabecula myocardium morphogenesis (GO:0003222) NEW7.330.034NKX2-5, GATA4
right ventricular cardiac muscle tissue morphogenesis (GO:0003221) -9.040.0ZFPM2, NKX2-5, GATA4
cellular response to gonadotropin stimulus (GO:0071371) NEW7.020.012GATA6, GATA4
regulation of cellular response to growth factor stimulus (GO:0090287) -4.290.024GATA6, JAG1, GATA4, NKX2-5
in utero embryonic development (GO:0001701) -4.40.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.008ZFPM2, NKX2-5, GATA4
cardiac muscle hypertrophy (GO:0003300) NEW6.840.014GATA6, GATA4
negative regulation of cellular response to growth factor stimulus (GO:0090288) NEW4.920.002GATA6, JAG1, GATA4, NKX2-5
chordate embryonic development (GO:0043009) -4.380.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of female gonad development (GO:2000194) NEW7.240.034ZFPM2, GATA4
negative regulation of female gonad development (GO:2000195) NEW8.340.001ZFPM2, GATA4
tube morphogenesis (GO:0035239) -4.350.007GATA6, TBX1, GATA4, NKX2-5
cardiac cell development (GO:0055006) -6.330.005JAG1, NKX2-5, GATA4
cardiac muscle cell differentiation (GO:0055007) -6.290.035GATA6, NKX2-5, GATA4
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.025ZFPM2, NKX2-5, GATA4
positive regulation of cell differentiation (GO:0045597) -3.010.001NKX2-5, GATA6, TBX1, GATA4, JAG1
negative regulation of cell differentiation (GO:0045596) -3.330.013ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of cell differentiation (GO:0045595) -2.420.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
response to acid chemical (GO:0001101) NEW4.050.013NKX2-5, GATA6, TBX1, GATA4, JAG1
negative regulation of developmental process (GO:0051093) -3.170.039ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
pancreatic A cell differentiation (GO:0003310) NEW8.630.002GATA6, GATA4
positive regulation of developmental process (GO:0051094) -2.770.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of RNA metabolic process (GO:0051254) -2.510.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
cardiac muscle tissue development (GO:0048738) -6.330.002ZFPM2, NKX2-5, GATA4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) -2.810.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
gland development (GO:0048732) -4.150.037GATA6, TBX1, NKX2-5
embryo development (GO:0009790) -4.20.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
ventricular cardiac muscle cell development (GO:0055015) NEW7.330.041NKX2-5, GATA4
positive regulation of cellular biosynthetic process (GO:0031328) -2.30.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of cellular metabolic process (GO:0031325) -1.810.016ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
regulation of heart growth (GO:0060420) -5.970.014GATA6, NKX2-5, GATA4
negative regulation of cardiac muscle cell apoptotic process (GO:0010667) NEW7.160.019NKX2-5, GATA4
striated muscle tissue development (GO:0014706) -5.230.002NKX2-5, GATA6, ZFPM2, GATA4, JAG1
negative regulation of striated muscle cell apoptotic process (GO:0010664) NEW6.90.034NKX2-5, GATA4
striated muscle cell differentiation (GO:0051146) -5.690.026GATA6, NKX2-5, GATA4
muscle adaptation (GO:0043500) NEW6.430.035GATA6, GATA4
morphogenesis of an epithelium (GO:0002009) -4.080.011NKX2-5, GATA6, TBX1, GATA4, JAG1
artery morphogenesis (GO:0048844) -5.880.025TBX1, JAG1, GATA4
muscle hypertrophy (GO:0014896) NEW6.680.019GATA6, GATA4
regulation of transcription from RNA polymerase II promoter (GO:0006357) -2.240.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
tissue morphogenesis (GO:0048729) -3.870.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
hematopoietic or lymphoid organ development (GO:0048534) -4.490.018TBX1, JAG1, GATA4, NKX2-5
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.033GATA6, JAG1, GATA4, NKX2-5
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) -2.350.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
neuron differentiation (GO:0030182) NEW4.170.006NKX2-5, GATA6, TBX1, GATA4, JAG1
pattern specification process (GO:0007389) -3.790.047GATA6, TBX1, JAG1, GATA4, NKX2-5
regulation of organ growth (GO:0046620) -5.410.002GATA6, NKX2-5, GATA4
embryonic heart tube anterior/posterior pattern specification (GO:0035054) NEW8.630.001NKX2-5, GATA4
pharyngeal system development (GO:0060037) -6.960.008TBX1, NKX2-5
cardiocyte differentiation (GO:0035051) -6.020.013GATA6, NKX2-5, GATA4
cardiac chamber morphogenesis (GO:0003206) -6.360.028GATA6, JAG1, GATA4
positive regulation of nitrogen compound metabolic process (GO:0051173) -2.290.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
mesenchyme development (GO:0060485) -5.70.0GATA6, ZFPM2, GATA4, NKX2-5
tube development (GO:0035295) -4.410.015GATA6, JAG1, GATA4, NKX2-5
gonadal mesoderm development (GO:0007506) NEW7.650.005ZFPM2, GATA4
heart development (GO:0007507) -4.240.035TBX1, JAG1, GATA4, NKX2-5
cardiac septum development (GO:0003279) -5.940.024NKX2-5, GATA4
outflow tract septum morphogenesis (GO:0003148) -7.090.0ZFPM2, GATA6, TBX1, NKX2-5
anatomical structure development (GO:0048856) -1.580.037ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
positive regulation of male gonad development (GO:2000020) NEW7.650.025ZFPM2, GATA4
regulation of multicellular organismal development (GO:2000026) -2.310.001ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
muscle tissue development (GO:0060537) -5.10.0NKX2-5, ZFPM2, GATA6, GATA4, JAG1
positive regulation of transcription, DNA-templated (GO:0045893) -2.560.0ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116ZFPM2, GATA4, NKX2-5, JAG1, GATA6, TBX1
intracellular membrane-bounded organelle (GO:0043231) 0.65ZFPM2, TBX1, GATA6, GATA4, NKX2-5
nucleus (GO:0005634) 1.075GATA6, TBX1, ZFPM2, GATA4, NKX2-5
intracellular organelle (GO:0043229) 0.515GATA6, TBX1, ZFPM2, GATA4, NKX2-5
intracellular part (GO:0044424) 0.285ZFPM2, TBX1, GATA6, GATA4, NKX2-5
membrane-bounded organelle (GO:0043227) 0.475GATA6, TBX1, ZFPM2, GATA4, NKX2-5
organelle (GO:0043226) 0.45GATA6, TBX1, ZFPM2, GATA4, NKX2-5
intracellular organelle part (GO:0044446) 0.814GATA6, ZFPM2, GATA4, NKX2-5
nuclear part (GO:0044428) 1.554ZFPM2, GATA6, GATA4, NKX2-5
organelle part (GO:0044422) 0.794ZFPM2, GATA6, GATA4, NKX2-5
nucleoplasm (GO:0005654) 1.893ZFPM2, GATA6, GATA4
protein complex (GO:0043234) 1.513GATA6, NKX2-5, GATA4
macromolecular complex (GO:0032991) 1.353GATA6, NKX2-5, GATA4
transcription factor complex (GO:0005667) 4.13GATA6, NKX2-5, GATA4
cytoplasm (GO:0005737) 1.012ZFPM2, NKX2-5
RNA polymerase II transcription factor complex (GO:0090575) 5.182NKX2-5, GATA4
extracellular region (GO:0005576) 2.182GDF1, JAG1
nuclear transcription factor complex (GO:0044798) 4.952NKX2-5, GATA4