Disease table of MUSCULAR DYSTROPHY, LIMB-GIRDLE, AUTOSOMAL RECESSIVE OMIM ID: PS253600

Gene-disease associations table

Gene	Associated with MUSCULAR DYSTROPHY, LIMB-GIRDLE, AUTOSOMAL RECESSIVE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TRIM32	ClinVar, OMIM, HUMSAVAR	HGNC link	9q33.1	2	PS209900, PS253600
DES	ClinVar, OMIM	HGNC link	2q35	5	181400, PS253600, PS601419, 142340, PS115200
LIMS2	ClinVar, OMIM	HGNC link	2q14.3	1	PS253600
FKTN	ClinVar, OMIM, HUMSAVAR	HGNC link	9q31.2	4	PS236670, PS613155, PS115200, PS253600
FKRP	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.32	3	PS613155, PS253600, PS236670
SGCG	ClinVar, OMIM, HUMSAVAR	HGNC link	13q12.12	1	PS253600
SGCD	ClinVar, OMIM, HUMSAVAR	HGNC link	5q33.2	2	PS115200, PS253600
SGCB	ClinVar, OMIM, HUMSAVAR	HGNC link	4q12	1	PS253600
SGCA	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.33	1	PS253600
TRAPPC11	ClinVar, OMIM, HUMSAVAR	HGNC link	4q35.1	1	PS253600
TTN	ClinVar, OMIM	HGNC link	2q31.2	8	PS192600, PS253600, 600334, PS115200, 603689, 603829, 611705, PS160150
ANO5	ClinVar, OMIM, HUMSAVAR	HGNC link	11p14.3	3	PS254130, PS253600, 166260
CAPN3	ClinVar, OMIM, HUMSAVAR	HGNC link	15q15.1	1	PS253600
DYSF	ClinVar, OMIM, HUMSAVAR	HGNC link	2p13.2	3	PS254130, PS253600, 606768
BVES	ClinVar, OMIM	HGNC link	6q21	1	PS253600
GMPPB	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	3	PS613155, PS253600, PS236670
PLEC	OMIM	HGNC link	8q24.3	5	612138, 131950, PS253600, 616487, 226670
DAG1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	2	PS236670, PS253600
ISPD	ClinVar, OMIM, HUMSAVAR	HGNC link	7p21.2	2	PS236670, PS253600
POMK	ClinVar, OMIM	HGNC link	8p11.21	2	PS236670, PS253600
TCAP	ClinVar, OMIM	HGNC link	17q12	2	PS192600, PS253600
POMGNT1	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.1	3	PS613155, PS253600, PS236670
POMT1	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.13	3	PS613155, PS253600, PS236670
POMT2	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.3	3	PS613155, PS253600, PS236670

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
3p21.31	2	GMPPB, DAG1

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
3p21	2	GMPPB, DAG1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
2q3	2	DES, TTN
3p2	2	GMPPB, DAG1
9q3	3	FKTN, POMT1, TRIM32

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	3	DES, LIMS2, TTN
3p	2	GMPPB, DAG1
4q	2	TRAPPC11, SGCB
9q	3	FKTN, POMT1, TRIM32
17q	2	SGCA, TCAP

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	2	SGCA, TCAP
3	2	GMPPB, DAG1
2	4	DYSF, DES, LIMS2, TTN
4	2	TRAPPC11, SGCB
9	3	FKTN, POMT1, TRIM32
8	2	PLEC, POMK

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
DES	YES	1	TRIM16	0
POMGNT1	YES	1	ZNF202	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TRIM32	DES	No	1	YWHAQ
TRIM32	TRAPPC11	No	2	TP73, TP53
TRIM32	TTN	No	3	MCM2, YWHAQ, CUL3
TRIM32	GMPPB	No	1	UBE2V1
TRIM32	PLEC	No	3	MCM2, CUL3, SFN
TRIM32	TCAP	No	1	ATXN1
DES	TTN	No	5	SP1, TRIM55, YWHAQ, CRYAB, TRIM63
DES	BVES	No	1	HSPB1
DES	GMPPB	No	1	JUP
DES	PLEC	No	4	PLEKHA5, SP1, JUP, SPTAN1
DES	TCAP	No	2	TRIM55, TRIM63
DES	POMGNT1	No	1	BRCA1
LIMS2	SGCG	No	1	APP
FKTN	FKRP	No	1	HLA-DPA1
FKTN	DAG1	No	1	HLA-DPA1
FKRP	DAG1	No	1	HLA-DPA1
FKRP	POMGNT1	No	2	HAUS7, SLC39A4
FKRP	POMT1	No	1	SYNE4
FKRP	POMT2	No	1	CD1B
SGCG	SGCD	No	1	FLNC
SGCG	CAPN3	No	1	FLNC
SGCD	SGCB	Yes	0
SGCD	CAPN3	No	1	FLNC
SGCB	POMT1	No	1	ZACN
TRAPPC11	TTN	No	2	NTRK1, ALB
TTN	CAPN3	Yes	0
TTN	PLEC	No	7	SP1, CDK2, MCM2, RAPGEF2, GAN, CUL3, CUL7
TTN	DAG1	No	1	ACTN1
TTN	TCAP	Yes	4	ANKRD2, TRIM55, HSPB2, TRIM63
CAPN3	TCAP	No	1	TTN
DYSF	DAG1	No	1	CAV3
GMPPB	PLEC	No	1	JUP
PLEC	DAG1	No	3	GRB2, PPP1CB, MAP2
DAG1	TCAP	No	1	FYN
DAG1	POMT1	No	1	HTR3C
DAG1	POMT2	No	1	HTR3C
POMK	POMGNT1	Yes	2	B4GALT3, FAM134C
POMK	POMT1	Yes	0
POMGNT1	POMT1	No	1	POMK
POMT1	POMT2	No	4	HTR3C, TMEM92, ATP1B4, CD244

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
GMPPB	DAG1	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
DES	FKRP	No	-	0
DES	TRAPPC11	No	-	1	UBC
DES	TTN	Yes	binding	27	TPM1, TMOD1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, UBC, TPM4
DES	CAPN3	No	-	1	TTN
DES	GMPPB	No	-	1	UBC
DES	DAG1	No	-	1	UBC
FKTN	POMGNT1	Yes	binding	0
FKRP	TTN	No	-	0
FKRP	DAG1	Yes	binding	0
TRAPPC11	TTN	No	-	1	UBC
TRAPPC11	GMPPB	No	-	1	UBC
TRAPPC11	DAG1	No	-	1	UBC
TTN	CAPN3	Yes	binding	0
TTN	GMPPB	No	-	1	UBC
TTN	DAG1	No	-	1	UBC
DYSF	DAG1	No	-	0
GMPPB	DAG1	No	-	1	UBC
PLEC	DAG1	No	-	3	LAMB3, LAMA3, LAMC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
SGCG	SGCD	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCB, SGCA, SSPN
SGCG	SGCB	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCD, SGCA, SSPN
SGCG	SGCA	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCD, SGCB, SSPN
SGCD	SGCB	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCA, SSPN, SGCG
SGCD	SGCA	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCB, SSPN, SGCG
SGCB	SGCA	Yes	Sarcoglycan-sarcospan complex SG-SPN	3	SGCD, SSPN, SGCG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
DES	PLEC	No	1	JUP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TTN	TCAP	Yes	2	TTN, TCAP
DAG1	POMGNT1	Yes	2	POMGNT1, DAG1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	7	SGCD, TTN, DES, SGCB, SGCA, SGCG, DAG1
Dilated cardiomyopathy	hsa05414	6.08	7	SGCD, TTN, DES, SGCB, SGCA, SGCG, DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	6	SGCD, DES, SGCB, SGCA, SGCG, DAG1
Viral myocarditis	hsa05416	6.45	5	SGCD, SGCA, DAG1, SGCB, SGCG
Other types of O-glycan biosynthesis	hsa00514	7.72	3	POMGNT1, POMT1, POMT2

NET-GE enrichment

Term	New enriched term	IC	Genes
Cardiovascular diseases	NEW	5.06	SGCD, TTN, DES, SGCB, SGCA, SGCG, CAPN3, DAG1
Other types of O-glycan biosynthesis (hsa00514)	-	7.72	POMGNT1, POMT1, POMT2
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	SGCD, TTN, DES, SGCB, SGCA, SGCG, CAPN3, DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)	-	6.32	SGCD, DES, SGCB, SGCA, SGCG, DAG1
Dilated cardiomyopathy (hsa05414)	-	6.08	SGCD, TTN, DES, SGCB, SGCA, SGCG, CAPN3, DAG1
Viral myocarditis (hsa05416)	-	6.45	SGCD, SGCA, DAG1, SGCB, SGCG

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Muscle contraction	R-HSA-397014	6.96	4	TTN, DYSF, DES, TCAP
Striated Muscle Contraction	R-HSA-390522	7.81	3	TTN, DES, TCAP
Cell-Cell communication	R-HSA-1500931	5.87	2	PLEC, LIMS2
Extracellular matrix organization	R-HSA-1474244	4.91	2	DAG1, PLEC
Cell junction organization	R-HSA-446728	6.51	2	PLEC, LIMS2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Muscle contraction (R-HSA-397014)	-	6.96	0.0	TTN, DYSF, DES, DAG1, TCAP
Striated Muscle Contraction (R-HSA-390522)	-	7.81	0.002	TTN, DES, TCAP

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	18	POMT1, PLEC, TRIM32, TCAP, TTN, POMT2, DYSF, DES, SGCG, POMGNT1, POMK, GMPPB, SGCA, ANO5, CAPN3, DAG1, BVES, LIMS2
protein binding (GO:0005515)	0.46	15	PLEC, TCAP, TTN, DYSF, DES, SGCG, POMGNT1, BVES, GMPPB, SGCA, ANO5, CAPN3, DAG1, TRIM32, LIMS2
catalytic activity (GO:0003824)	1.05	11	POMT1, ISPD, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, GMPPB, FKTN, CAPN3
transferase activity (GO:0016740)	1.95	10	POMT1, FKTN, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, GMPPB, ISPD
cation binding (GO:0043169)	1.4	9	POMT1, TTN, DYSF, POMT2, SGCA, CAPN3, DAG1, TRIM32, LIMS2
metal ion binding (GO:0046872)	1.41	9	POMT1, TTN, DYSF, POMT2, SGCA, CAPN3, DAG1, TRIM32, LIMS2
ion binding (GO:0043167)	1.36	9	POMT1, TTN, DYSF, POMT2, SGCA, CAPN3, DAG1, TRIM32, LIMS2
cytoskeletal protein binding (GO:0008092)	3.02	7	TCAP, TTN, TRIM32, DES, CAPN3, DAG1, PLEC
structural molecule activity (GO:0005198)	3.1	7	TCAP, TTN, DES, BVES, CAPN3, DAG1, PLEC
organic cyclic compound binding (GO:0097159)	1.05	6	TTN, TRIM32, BVES, POMK, GMPPB, PLEC
heterocyclic compound binding (GO:1901363)	1.06	6	TTN, TRIM32, BVES, POMK, GMPPB, PLEC
carbohydrate derivative binding (GO:0097367)	2.03	5	TTN, POMK, GMPPB, DAG1, BVES
structural constituent of muscle (GO:0008307)	6.02	5	TTN, CAPN3, DAG1, PLEC, TCAP
calcium ion binding (GO:0005509)	3.17	5	DYSF, TTN, CAPN3, DAG1, SGCA
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	4	TTN, POMK, GMPPB, ISPD
nucleotide binding (GO:0000166)	1.96	4	TTN, POMK, GMPPB, BVES
small molecule binding (GO:0036094)	1.89	4	TTN, POMK, GMPPB, BVES
nucleoside phosphate binding (GO:1901265)	1.96	4	TTN, POMK, GMPPB, BVES
purine ribonucleotide binding (GO:0032555)	2.2	4	TTN, POMK, GMPPB, BVES
purine nucleotide binding (GO:0017076)	2.19	4	TTN, POMK, GMPPB, BVES
ribonucleotide binding (GO:0032553)	2.19	4	TTN, POMK, GMPPB, BVES
adenyl nucleotide binding (GO:0030554)	2.4	3	TTN, POMK, BVES
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	TTN, POMK, GMPPB
actin binding (GO:0003779)	3.74	3	TTN, DAG1, PLEC
adenyl ribonucleotide binding (GO:0032559)	2.41	3	TTN, POMK, BVES
transferase activity, transferring glycosyl groups (GO:0016757)	4.08	3	POMGNT1, POMT1, POMT2
ribonucleoside binding (GO:0032549)	2.22	3	TTN, POMK, GMPPB
transferase activity, transferring hexosyl groups (GO:0016758)	4.43	3	POMGNT1, POMT1, POMT2
purine ribonucleoside binding (GO:0032550)	2.22	3	TTN, POMK, GMPPB
purine nucleoside binding (GO:0001883)	2.22	3	TTN, POMK, GMPPB
nucleoside binding (GO:0001882)	2.21	3	TTN, POMK, GMPPB
titin binding (GO:0031432)	7.25	2	CAPN3, TCAP
nucleotidyltransferase activity (GO:0016779)	4.81	2	GMPPB, ISPD
alpha-actinin binding (GO:0051393)	6.6	2	TTN, DAG1
transition metal ion binding (GO:0046914)	2.48	2	TRIM32, LIMS2
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	TTN, POMK
kinase activity (GO:0016301)	2.93	2	TTN, POMK
dolichyl-phosphate-mannose-protein mannosyltransferase activity (GO:0004169)	7.95	2	POMT1, POMT2
protein self-association (GO:0043621)	5.93	2	TTN, TRIM32
identical protein binding (GO:0042802)	2.63	2	TTN, DES
macromolecular complex binding (GO:0044877)	2.61	2	TTN, DAG1
zinc ion binding (GO:0008270)	2.66	2	TRIM32, LIMS2
nucleic acid binding (GO:0003676)	1.44	2	TRIM32, PLEC
RNA binding (GO:0003723)	2.36	2	TRIM32, PLEC
protein complex binding (GO:0032403)	3.09	2	TTN, DAG1
actinin binding (GO:0042805)	6.3	2	TTN, DAG1
protein kinase activity (GO:0004672)	3.27	2	TTN, POMK
mannosyltransferase activity (GO:0000030)	6.52	2	POMT1, POMT2
ATP binding (GO:0005524)	2.43	2	TTN, POMK
protein domain specific binding (GO:0019904)	3.32	2	DAG1, TCAP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
titin binding (GO:0031432)	-	7.25	0.011	CAPN3, TCAP
alpha-actinin binding (GO:0051393)	-	6.6	0.032	TTN, DAG1
cytoskeletal protein binding (GO:0008092)	-	3.02	0.003	TCAP, TTN, TRIM32, DES, CAPN3, DAG1, PLEC
dolichyl-phosphate-mannose-protein mannosyltransferase activity (GO:0004169)	-	7.95	0.001	POMT1, POMT2
transferase activity (GO:0016740)	-	1.95	0.016	POMT1, FKTN, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, GMPPB, ISPD
actin filament binding (GO:0051015)	NEW	4.93	0.017	TTN, TRIM32, CAPN3, PLEC
structural molecule activity (GO:0005198)	-	3.1	0.0	TCAP, TTN, DYSF, DES, SGCA, BVES, GMPPB, SGCG, DAG1, CAPN3, TRIM32, PLEC
actin binding (GO:0003779)	-	3.74	0.002	TCAP, TTN, DYSF, SGCG, CAPN3, DAG1, TRIM32, PLEC
structural constituent of muscle (GO:0008307)	-	6.02	0.0	TCAP, TTN, DES, CAPN3, DAG1, PLEC
calcium ion binding (GO:0005509)	-	3.17	0.012	TCAP, TTN, DYSF, DES, SGCA, GMPPB, SGCG, CAPN3, DAG1, TRIM32
ankyrin binding (GO:0030506)	NEW	6.74	0.036	TTN, PLEC
mannosyltransferase activity (GO:0000030)	-	6.52	0.026	POMT1, POMT2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	22	POMT1, TCAP, DES, SGCG, GMPPB, FKTN, DAG1, SGCB, SGCA, POMK, DYSF, LIMS2, SGCD, TRIM32, POMGNT1, ISPD, CAPN3, TTN, POMT2, BVES, FKRP, PLEC
single-organism process (GO:0044699)	0.48	21	SGCD, SGCA, PLEC, ISPD, TCAP, POMT1, POMT2, DYSF, DES, SGCB, SGCG, POMGNT1, TTN, FKRP, CAPN3, BVES, FKTN, DAG1, POMK, TRIM32, LIMS2
single-organism cellular process (GO:0044763)	0.65	20	SGCD, PLEC, ISPD, TCAP, POMT1, POMT2, DYSF, DES, SGCB, BVES, POMGNT1, TTN, POMK, SGCG, FKTN, FKRP, CAPN3, DAG1, TRIM32, LIMS2
cellular component organization (GO:0016043)	1.24	15	SGCD, PLEC, TCAP, TTN, TRIM32, DES, SGCB, SGCG, BVES, SGCA, POMT1, CAPN3, DAG1, DYSF, LIMS2
cellular component organization or biogenesis (GO:0071840)	1.22	15	SGCD, PLEC, TCAP, TTN, TRIM32, DES, SGCB, BVES, SGCA, POMT1, CAPN3, DAG1, DYSF, LIMS2, SGCG
single-organism developmental process (GO:0044767)	1.49	13	SGCD, TCAP, TTN, POMT1, POMT2, SGCB, BVES, POMK, SGCA, FKTN, DAG1, CAPN3, SGCG
developmental process (GO:0032502)	1.36	13	SGCD, TCAP, TTN, POMT1, POMT2, SGCB, BVES, POMK, SGCA, FKTN, DAG1, CAPN3, SGCG
anatomical structure development (GO:0048856)	1.58	13	SGCD, TCAP, TTN, POMT1, POMT2, SGCB, SGCA, POMK, BVES, FKTN, CAPN3, DAG1, SGCG
organic substance metabolic process (GO:0071704)	0.63	12	POMT1, FKTN, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, GMPPB, ISPD, DAG1, CAPN3
multicellular organismal process (GO:0032501)	1.45	12	SGCD, TCAP, TTN, POMT2, DYSF, DES, POMT1, SGCA, POMK, SGCG, DAG1, BVES
metabolic process (GO:0008152)	0.58	12	POMT1, FKTN, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, GMPPB, ISPD, DAG1, CAPN3
primary metabolic process (GO:0044238)	0.69	12	POMT1, FKTN, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, GMPPB, ISPD, DAG1, CAPN3
protein metabolic process (GO:0019538)	1.45	11	POMT1, FKTN, TTN, TRIM32, POMT2, POMK, POMGNT1, FKRP, ISPD, CAPN3, DAG1
cellular metabolic process (GO:0044237)	0.69	11	POMT1, FKTN, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, GMPPB, ISPD, DAG1
macromolecule metabolic process (GO:0043170)	0.83	11	POMT1, ISPD, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, FKTN, CAPN3, DAG1
cellular protein metabolic process (GO:0044267)	1.63	10	POMT1, ISPD, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
cellular macromolecule metabolic process (GO:0044260)	0.93	10	POMT1, ISPD, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
cellular protein modification process (GO:0006464)	1.79	10	POMT1, ISPD, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
macromolecule modification (GO:0043412)	1.73	10	POMT1, FKTN, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, ISPD, DAG1
protein modification process (GO:0036211)	1.79	10	POMT1, ISPD, TTN, TRIM32, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
biological regulation (GO:0065007)	0.39	10	POMT1, TTN, POMT2, TRIM32, DES, BVES, FKTN, CAPN3, DAG1, LIMS2
regulation of biological process (GO:0050789)	0.45	10	POMT1, TTN, POMT2, TRIM32, DES, BVES, FKTN, CAPN3, DAG1, LIMS2
single-organism metabolic process (GO:0044710)	1.63	9	POMT1, ISPD, TRIM32, POMT2, POMK, POMGNT1, FKRP, FKTN, DAG1
animal organ development (GO:0048513)	2.53	9	SGCD, TCAP, SGCB, BVES, POMK, SGCA, FKTN, CAPN3, SGCG
regulation of cellular process (GO:0050794)	0.5	9	POMT1, TTN, TRIM32, POMT2, BVES, FKTN, CAPN3, DAG1, LIMS2
carbohydrate metabolic process (GO:0005975)	3.26	8	POMT1, ISPD, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
protein glycosylation (GO:0006486)	4.2	8	POMT1, ISPD, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
cellular developmental process (GO:0048869)	1.82	8	SGCB, TCAP, TTN, TRIM32, SGCD, BVES, SGCG, DAG1
glycosylation (GO:0070085)	4.16	8	POMT1, ISPD, POMT2, POMK, POMGNT1, FKRP, FKTN, DAG1
macromolecule glycosylation (GO:0043413)	4.2	8	POMT1, ISPD, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
regulation of signaling (GO:0023051)	1.72	8	POMT1, TRIM32, POMT2, BVES, FKTN, DAG1, CAPN3, LIMS2
single-organism carbohydrate metabolic process (GO:0044723)	3.42	8	POMT1, ISPD, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
protein O-linked glycosylation (GO:0006493)	5.13	8	POMT1, ISPD, POMT2, FKRP, POMGNT1, POMK, FKTN, DAG1
system process (GO:0003008)	2.3	8	SGCD, TCAP, TTN, DYSF, DES, SGCA, POMK, SGCG
organelle organization (GO:0006996)	2.02	7	TCAP, TTN, DYSF, DES, CAPN3, DAG1, TRIM32
muscle organ development (GO:0007517)	4.98	7	SGCD, SGCB, BVES, SGCA, FKTN, CAPN3, SGCG
regulation of signal transduction (GO:0009966)	1.84	7	POMT1, TRIM32, POMT2, FKTN, DAG1, CAPN3, LIMS2
regulation of response to stimulus (GO:0048583)	1.54	7	POMT1, TRIM32, POMT2, FKTN, DAG1, CAPN3, LIMS2
cell development (GO:0048468)	3.28	7	SGCD, TCAP, TTN, SGCB, BVES, SGCG, DAG1
movement of cell or subcellular component (GO:0006928)	2.61	7	TCAP, TTN, DES, BVES, POMK, ISPD, DAG1
single-organism organelle organization (GO:1902589)	2.68	7	TCAP, TTN, DYSF, DES, CAPN3, DAG1, TRIM32
muscle structure development (GO:0061061)	4.96	7	SGCD, SGCB, BVES, SGCA, FKTN, CAPN3, SGCG
regulation of cell communication (GO:0010646)	1.73	7	POMT1, TRIM32, POMT2, FKTN, DAG1, CAPN3, LIMS2
muscle cell development (GO:0055001)	5.29	6	SGCD, TCAP, TTN, SGCB, BVES, SGCG
cytoskeleton organization (GO:0007010)	3.22	6	TCAP, TTN, TRIM32, DES, DAG1, CAPN3
regulation of metabolic process (GO:0019222)	1.02	6	TTN, TRIM32, BVES, FKTN, DAG1, CAPN3
single-multicellular organism process (GO:0044707)	1.78	6	POMT1, TCAP, POMT2, BVES, POMK, DAG1
regulation of macromolecule metabolic process (GO:0060255)	1.08	6	TTN, TRIM32, BVES, FKTN, DAG1, CAPN3
response to stimulus (GO:0050896)	1.22	6	TCAP, TTN, TRIM32, BVES, DAG1, CAPN3
regulation of cellular metabolic process (GO:0031323)	1.07	6	TTN, TRIM32, BVES, FKTN, DAG1, CAPN3
membrane organization (GO:0061024)	3.04	6	SGCB, DYSF, SGCD, SGCA, SGCG, CAPN3
regulation of multicellular organismal process (GO:0051239)	1.87	6	TRIM32, DES, BVES, CAPN3, DAG1, LIMS2
localization (GO:0051179)	1.4	6	ANO5, TTN, BVES, TRAPPC11, CAPN3, DAG1
protein O-linked mannosylation (GO:0035269)	7.09	5	FKTN, POMT1, POMT2, FKRP, ISPD
organic substance biosynthetic process (GO:1901576)	1.34	5	POMT2, POMT1, GMPPB, FKRP, ISPD
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	TTN, TRIM32, DAG1, CAPN3, FKTN
actin filament-based process (GO:0030029)	3.94	5	TTN, TRIM32, DES, CAPN3, TCAP
muscle contraction (GO:0006936)	4.37	5	TTN, DYSF, DES, SGCA, TCAP
cellular biosynthetic process (GO:0044249)	1.37	5	POMT2, POMT1, GMPPB, FKRP, ISPD
regulation of developmental process (GO:0050793)	2.1	5	TRIM32, CAPN3, DAG1, BVES, LIMS2
regulation of response to stress (GO:0080134)	2.53	5	CAPN3, POMT1, POMT2, TRIM32, FKTN
transport (GO:0006810)	1.51	5	TTN, DAG1, TRAPPC11, ANO5, BVES
regulation of protein metabolic process (GO:0051246)	1.93	5	TTN, TRIM32, CAPN3, DAG1, FKTN
mannosylation (GO:0097502)	6.26	5	FKTN, POMT1, POMT2, FKRP, ISPD
biosynthetic process (GO:0009058)	1.32	5	POMT2, POMT1, GMPPB, FKRP, ISPD
regulation of primary metabolic process (GO:0080090)	1.08	5	TTN, TRIM32, DAG1, CAPN3, FKTN
muscle system process (GO:0003012)	4.18	5	TTN, DYSF, DES, SGCA, TCAP
cellular component assembly (GO:0022607)	2.14	5	TTN, CAPN3, TCAP, PLEC, LIMS2
positive regulation of biological process (GO:0048518)	1.2	5	TRIM32, CAPN3, DAG1, LIMS2, BVES
negative regulation of biological process (GO:0048519)	1.33	5	FKTN, TRIM32, DAG1, CAPN3, LIMS2
protein mannosylation (GO:0035268)	6.73	5	FKRP, POMT1, POMT2, FKTN, ISPD
establishment of localization (GO:0051234)	1.48	5	TTN, DAG1, TRAPPC11, ANO5, BVES
negative regulation of cellular process (GO:0048523)	1.41	5	FKTN, TRIM32, DAG1, CAPN3, LIMS2
positive regulation of cellular process (GO:0048522)	1.3	5	TRIM32, CAPN3, DAG1, BVES, LIMS2
response to abiotic stimulus (GO:0009628)	2.8	4	TTN, TRIM32, CAPN3, TCAP
striated muscle cell development (GO:0055002)	5.42	4	TTN, SGCB, TCAP, BVES
regulation of localization (GO:0032879)	1.94	4	TRIM32, DAG1, CAPN3, BVES
negative regulation of metabolic process (GO:0009892)	1.93	4	TRIM32, DAG1, CAPN3, FKTN
regulation of biological quality (GO:0065008)	1.68	4	TRIM32, DAG1, CAPN3, BVES
cardiac cell development (GO:0055006)	6.33	4	TTN, SGCB, BVES, TCAP
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	4	POMT2, POMT1, GMPPB, FKRP
carbohydrate derivative metabolic process (GO:1901135)	3.07	4	GMPPB, POMT1, POMT2, FKRP
regulation of cellular response to stress (GO:0080135)	3.4	4	POMT1, POMT2, TRIM32, FKTN
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	TRIM32, DAG1, CAPN3, FKTN
actin cytoskeleton organization (GO:0030036)	4.1	4	TTN, TRIM32, CAPN3, TCAP
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	TRIM32, DAG1, CAPN3, FKTN
response to stress (GO:0006950)	1.8	4	BVES, TRIM32, CAPN3, TCAP
anatomical structure morphogenesis (GO:0009653)	2.53	4	TTN, DAG1, BVES, TCAP
regulation of multicellular organismal development (GO:2000026)	2.31	4	TRIM32, DAG1, CAPN3, LIMS2
regulation of protein modification process (GO:0031399)	2.32	4	TTN, DAG1, CAPN3, FKTN
response to chemical (GO:0042221)	1.98	4	TTN, TRIM32, DAG1, CAPN3
cardiac muscle cell development (GO:0055013)	6.4	4	TTN, SGCB, BVES, TCAP
regulation of intracellular signal transduction (GO:1902531)	2.31	4	TRIM32, DAG1, CAPN3, FKTN
regulation of molecular function (GO:0065009)	1.78	4	TTN, TRIM32, CAPN3, BVES
regulation of phosphate metabolic process (GO:0019220)	2.35	3	TTN, DAG1, FKTN
positive regulation of metabolic process (GO:0009893)	1.74	3	TRIM32, CAPN3, BVES
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	DAG1, BVES, LIMS2
macromolecular complex subunit organization (GO:0043933)	2.14	3	TTN, CAPN3, TCAP
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	TRIM32, CAPN3, FKTN
negative regulation of response to stimulus (GO:0048585)	2.52	3	TRIM32, DAG1, FKTN
positive regulation of response to stimulus (GO:0048584)	2.18	3	TRIM32, CAPN3, LIMS2
regulation of cellular component organization (GO:0051128)	2.01	3	TRIM32, DAG1, BVES
positive regulation of signaling (GO:0023056)	2.41	3	TRIM32, BVES, LIMS2
negative regulation of signaling (GO:0023057)	2.65	3	TRIM32, DAG1, FKTN
striated muscle tissue development (GO:0014706)	5.23	3	SGCD, BVES, SGCG
negative regulation of cell communication (GO:0010648)	2.66	3	TRIM32, DAG1, FKTN
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	POMT1, POMT2, FKRP
cell adhesion (GO:0007155)	2.82	3	DAG1, LIMS2, BVES
regulation of cell death (GO:0010941)	2.43	3	TRIM32, CAPN3, LIMS2
glycoprotein metabolic process (GO:0009100)	5.23	3	POMT1, POMT2, FKRP
multicellular organism development (GO:0007275)	2.54	3	POMT1, POMT2, BVES
actomyosin structure organization (GO:0031032)	5.4	3	TTN, CAPN3, TCAP
negative regulation of protein metabolic process (GO:0051248)	2.82	3	CAPN3, DAG1, FKTN
organelle assembly (GO:0070925)	3.75	3	TTN, CAPN3, TCAP
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	TRIM32, CAPN3, BVES
negative regulation of signal transduction (GO:0009968)	2.75	3	TRIM32, DAG1, FKTN
regulation of apoptotic process (GO:0042981)	2.5	3	TRIM32, CAPN3, LIMS2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	TRIM32, CAPN3, FKTN
actin-myosin filament sliding (GO:0033275)	6.09	3	TTN, DES, TCAP
glycoprotein biosynthetic process (GO:0009101)	5.86	3	POMT1, POMT2, FKRP
macromolecular complex assembly (GO:0065003)	2.55	3	TTN, CAPN3, TCAP
regulation of programmed cell death (GO:0043067)	2.49	3	TRIM32, CAPN3, LIMS2
negative regulation of apoptotic process (GO:0043066)	3.04	3	TRIM32, CAPN3, LIMS2
tissue morphogenesis (GO:0048729)	3.87	3	TTN, DAG1, TCAP
proteolysis (GO:0006508)	2.73	3	FKRP, CAPN3, DAG1
biological adhesion (GO:0022610)	2.81	3	DAG1, BVES, LIMS2
negative regulation of programmed cell death (GO:0043069)	3.02	3	TRIM32, CAPN3, LIMS2
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	TRIM32, CAPN3, BVES
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	3	TTN, CAPN3, TCAP
regulation of cell proliferation (GO:0042127)	2.41	3	TRIM32, FKTN, LIMS2
negative regulation of cell proliferation (GO:0008285)	3.26	3	TRIM32, FKTN, LIMS2
protein complex assembly (GO:0006461)	2.78	3	TTN, CAPN3, TCAP
myofibril assembly (GO:0030239)	6.43	3	TTN, CAPN3, TCAP
negative regulation of cell death (GO:0060548)	2.95	3	TRIM32, CAPN3, LIMS2
regulation of catalytic activity (GO:0050790)	1.97	3	TTN, CAPN3, BVES
regulation of biosynthetic process (GO:0009889)	1.37	3	TRIM32, CAPN3, FKTN
tissue development (GO:0009888)	3.27	3	SGCD, BVES, SGCG
muscle fiber development (GO:0048747)	5.8	3	TTN, SGCB, TCAP
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	TTN, DAG1, FKTN
actin filament-based movement (GO:0030048)	5.54	3	TTN, DES, TCAP
regulation of cell differentiation (GO:0045595)	2.42	3	TRIM32, DAG1, CAPN3
macromolecule biosynthetic process (GO:0009059)	1.61	3	POMT1, POMT2, FKRP
sarcomere organization (GO:0045214)	6.4	3	TTN, CAPN3, TCAP
negative regulation of intracellular signal transduction (GO:1902532)	3.63	3	TRIM32, DAG1, FKTN
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	3	TTN, CAPN3, TCAP
protein complex subunit organization (GO:0071822)	2.6	3	TTN, CAPN3, TCAP
single-organism localization (GO:1902578)	2.09	3	TTN, CAPN3, DAG1
regulation of phosphorylation (GO:0042325)	2.5	3	TTN, DAG1, FKTN
muscle filament sliding (GO:0030049)	6.09	3	TTN, DES, TCAP
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	3	CAPN3, DAG1, FKTN
regulation of locomotion (GO:0040012)	3.12	3	TRIM32, DAG1, BVES
vesicle-mediated transport (GO:0016192)	2.72	3	TTN, TRAPPC11, BVES
positive regulation of developmental process (GO:0051094)	2.77	3	TRIM32, DAG1, CAPN3
negative regulation of protein modification process (GO:0031400)	3.4	3	CAPN3, DAG1, FKTN
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	TRIM32, CAPN3, FKTN
muscle tissue development (GO:0060537)	5.1	3	SGCD, SGCG, BVES
actin-mediated cell contraction (GO:0070252)	5.88	3	TTN, DES, TCAP
regulation of protein phosphorylation (GO:0001932)	2.57	3	TTN, DAG1, FKTN
protein localization (GO:0008104)	2.36	2	CAPN3, DAG1
anatomical structure homeostasis (GO:0060249)	4.25	2	TRIM32, CAPN3
regulation of transport (GO:0051049)	2.24	2	CAPN3, BVES
circulatory system process (GO:0003013)	4.38	2	SGCD, SGCG
heart process (GO:0003015)	7.02	2	SGCD, SGCG
neuron projection guidance (GO:0097485)	4.43	2	DAG1, ISPD
cellular macromolecule localization (GO:0070727)	3.1	2	CAPN3, DAG1
positive regulation of signal transduction (GO:0009967)	2.5	2	TRIM32, LIMS2
striated muscle myosin thick filament assembly (GO:0071688)	8.63	2	TTN, TCAP
response to mechanical stimulus (GO:0009612)	4.41	2	TTN, TCAP
positive regulation of molecular function (GO:0044093)	2.23	2	TRIM32, CAPN3
macromolecule localization (GO:0033036)	2.34	2	CAPN3, DAG1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	2	TRIM32, CAPN3
cellular homeostasis (GO:0019725)	3.23	2	TRIM32, CAPN3
cell-substrate adhesion (GO:0031589)	4.75	2	DAG1, BVES
sarcomerogenesis (GO:0048769)	8.63	2	TTN, TCAP
response to calcium ion (GO:0051592)	4.98	2	TTN, CAPN3
regulation of cell shape (GO:0008360)	4.77	2	DAG1, BVES
regulation of proteolysis (GO:0030162)	3.2	2	TRIM32, CAPN3
response to metal ion (GO:0010038)	3.91	2	TTN, CAPN3
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	TRIM32, CAPN3
response to inorganic substance (GO:0010035)	3.56	2	TTN, CAPN3
response to organic substance (GO:0010033)	2.2	2	TRIM32, DAG1
negative regulation of phosphorylation (GO:0042326)	3.7	2	DAG1, FKTN
cell wall glycoprotein biosynthetic process (GO:0031506)	8.34	2	POMT1, POMT2
response to external stimulus (GO:0009605)	2.55	2	TTN, TCAP
cell motility (GO:0048870)	3.02	2	POMK, BVES
cellular component macromolecule biosynthetic process (GO:0070589)	8.34	2	POMT1, POMT2
extracellular matrix organization (GO:0030198)	4.01	2	POMT1, DAG1
muscle tissue morphogenesis (GO:0060415)	5.62	2	TTN, TCAP
regulation of cell morphogenesis (GO:0022604)	3.4	2	DAG1, BVES
negative regulation of biosynthetic process (GO:0009890)	2.47	2	TRIM32, CAPN3
detection of abiotic stimulus (GO:0009582)	4.96	2	TTN, TCAP
muscle cell cellular homeostasis (GO:0046716)	6.9	2	TRIM32, CAPN3
cell wall macromolecule metabolic process (GO:0044036)	7.65	2	POMT1, POMT2
negative regulation of gene expression (GO:0010629)	2.48	2	TRIM32, CAPN3
axon guidance (GO:0007411)	4.44	2	DAG1, ISPD
cell wall macromolecule biosynthetic process (GO:0044038)	8.34	2	POMT1, POMT2
response to muscle stretch (GO:0035994)	6.78	2	TTN, TCAP
detection of muscle stretch (GO:0035995)	8.34	2	TTN, TCAP
mannoprotein biosynthetic process (GO:0006057)	8.34	2	POMT1, POMT2
mannoprotein metabolic process (GO:0006056)	8.34	2	POMT1, POMT2
cell migration (GO:0016477)	3.12	2	POMK, BVES
single organism cell adhesion (GO:0098602)	3.63	2	BVES, LIMS2
cell-cell adhesion (GO:0098609)	3.34	2	LIMS2, BVES
regulation of heart contraction (GO:0008016)	4.35	2	DES, BVES
regulation of blood circulation (GO:1903522)	4.05	2	DES, BVES
cell wall mannoprotein biosynthetic process (GO:0000032)	8.34	2	POMT1, POMT2
detection of stimulus (GO:0051606)	3.22	2	TTN, TCAP
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	TRIM32, CAPN3
muscle hypertrophy (GO:0014896)	6.68	2	TTN, TCAP
striated muscle hypertrophy (GO:0014897)	6.78	2	TTN, TCAP
regulation of cell motility (GO:2000145)	3.16	2	TRIM32, DAG1
regulation of endoplasmic reticulum unfolded protein response (GO:1900101)	6.4	2	POMT1, POMT2
single-organism membrane organization (GO:0044802)	3.19	2	CAPN3, DYSF
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	TRIM32, CAPN3
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	DAG1, FKTN
phosphorylation (GO:0016310)	2.63	2	TTN, POMK
cell differentiation (GO:0030154)	2.14	2	TRIM32, BVES
striated muscle contraction (GO:0006941)	5.37	2	TTN, TCAP
heart contraction (GO:0060047)	7.02	2	SGCD, SGCG
single organismal cell-cell adhesion (GO:0016337)	3.69	2	BVES, LIMS2
positive regulation of cell communication (GO:0010647)	2.41	2	TRIM32, LIMS2
cardiac muscle contraction (GO:0060048)	5.88	2	TTN, TCAP
negative regulation of MAPK cascade (GO:0043409)	4.74	2	DAG1, FKTN
regulation of MAPK cascade (GO:0043408)	3.22	2	DAG1, FKTN
regulation of system process (GO:0044057)	3.53	2	DES, BVES
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	TRIM32, DAG1
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	CAPN3, LIMS2
cardiac muscle hypertrophy (GO:0003300)	6.84	2	TTN, TCAP
positive regulation of protein metabolic process (GO:0051247)	2.43	2	TRIM32, CAPN3
regulation of cell development (GO:0060284)	3.01	2	TRIM32, DAG1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	TRIM32, CAPN3
chain elongation of O-linked mannose residue (GO:0044845)	8.34	2	POMT1, POMT2
skeletal muscle thin filament assembly (GO:0030240)	8.12	2	TTN, TCAP
actin filament organization (GO:0007015)	4.54	2	TTN, TCAP
cardiac muscle tissue morphogenesis (GO:0055008)	5.8	2	TTN, TCAP
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	TRIM32, CAPN3
cell junction assembly (GO:0034329)	4.86	2	PLEC, LIMS2
negative regulation of developmental process (GO:0051093)	3.17	2	CAPN3, LIMS2
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	TRIM32, CAPN3
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	TRIM32, CAPN3
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	TRIM32, CAPN3
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	TRIM32, CAPN3
regulation of RNA metabolic process (GO:0051252)	1.52	2	TRIM32, CAPN3
cardiac muscle tissue development (GO:0048738)	6.33	2	SGCD, SGCG
cardiac muscle fiber development (GO:0048739)	7.65	2	TTN, TCAP
positive regulation of proteolysis (GO:0045862)	3.86	2	TRIM32, CAPN3
myosin filament assembly (GO:0031034)	8.63	2	TTN, TCAP
myosin filament organization (GO:0031033)	8.63	2	TTN, TCAP
positive regulation of growth (GO:0045927)	4.25	2	TRIM32, CAPN3
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	TRIM32, CAPN3
skeletal muscle myosin thick filament assembly (GO:0030241)	8.63	2	TTN, TCAP
cell junction organization (GO:0034330)	4.51	2	PLEC, LIMS2
homeostatic process (GO:0042592)	2.61	2	TRIM32, CAPN3
cardiac myofibril assembly (GO:0055003)	7.02	2	TTN, TCAP
cell cycle process (GO:0022402)	2.75	2	TTN, CAPN3
regulation of muscle cell differentiation (GO:0051147)	4.68	2	TRIM32, CAPN3
cellular macromolecular complex assembly (GO:0034622)	3.18	2	TTN, TCAP
detection of mechanical stimulus (GO:0050982)	5.94	2	TTN, TCAP
regulation of growth (GO:0040008)	3.26	2	TRIM32, CAPN3
extracellular structure organization (GO:0043062)	4.0	2	POMT1, DAG1
regulation of gene expression (GO:0010468)	1.37	2	TRIM32, CAPN3
detection of external stimulus (GO:0009581)	4.98	2	TTN, TCAP
protein phosphorylation (GO:0006468)	2.89	2	TTN, POMK
regulation of cell migration (GO:0030334)	3.23	2	TRIM32, DAG1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	TRIM32, CAPN3
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	DAG1, FKTN
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	TRIM32, CAPN3
cellular protein localization (GO:0034613)	3.11	2	CAPN3, DAG1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	TRIM32, CAPN3
single-organism transport (GO:0044765)	2.18	2	TTN, DAG1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	TRIM32, CAPN3
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	TRIM32, CAPN3
cellular protein complex assembly (GO:0043623)	3.9	2	TTN, TCAP
cellular localization (GO:0051641)	2.32	2	CAPN3, DAG1
locomotion (GO:0040011)	2.91	2	POMK, BVES
heart development (GO:0007507)	4.24	2	TCAP, BVES
regulation of cellular component movement (GO:0051270)	3.08	2	TRIM32, DAG1
positive regulation of locomotion (GO:0040017)	3.71	2	TRIM32, BVES
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	TTN, POMK
phosphorus metabolic process (GO:0006793)	2.15	2	TTN, POMK
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	DAG1, FKTN
single-organism cellular localization (GO:1902580)	3.16	2	CAPN3, DAG1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
myosin filament assembly (GO:0031034)	-	8.63	0.01	TTN, TCAP
cardiac muscle cell development (GO:0055013)	-	6.4	0.004	TTN, SGCB, TCAP, BVES
actomyosin structure organization (GO:0031032)	-	5.4	0.039	TTN, CAPN3, TCAP
skeletal muscle myosin thick filament assembly (GO:0030241)	-	8.63	0.01	TTN, TCAP
skeletal muscle thin filament assembly (GO:0030240)	-	8.12	0.01	TTN, TCAP
muscle system process (GO:0003012)	-	4.18	0.038	TCAP, TTN, DYSF, DES, SGCA, CAPN3, DAG1
muscle structure development (GO:0061061)	-	4.96	0.0	SGCB, TCAP, DYSF, SGCD, SGCG, POMGNT1, SGCA, FKTN, CAPN3, DAG1, BVES
myosin filament organization (GO:0031033)	-	8.63	0.01	TTN, TCAP
protein mannosylation (GO:0035268)	-	6.73	0.0	POMT1, POMT2, ISPD
protein O-linked mannosylation (GO:0035269)	-	7.09	0.0	POMT1, POMT2, ISPD
response to muscle stretch (GO:0035994)	-	6.78	0.006	TTN, TCAP
detection of muscle stretch (GO:0035995)	-	8.34	0.016	TTN, TCAP
muscle organ development (GO:0007517)	-	4.98	0.0	SGCB, TCAP, DYSF, SGCD, SGCG, POMGNT1, SGCA, FKTN, CAPN3, DAG1, BVES
protein glycosylation (GO:0006486)	-	4.2	0.001	POMT1, POMT2, POMGNT1, POMK, GMPPB, ISPD
striated muscle myosin thick filament assembly (GO:0071688)	-	8.63	0.01	TTN, TCAP
actin-myosin filament sliding (GO:0033275)	-	6.09	0.01	TTN, DES, TCAP
organ development (GO:0048513)	-	2.53	0.0	SGCD, TCAP, TTN, SGCB, BVES, POMK, SGCA, FKTN, CAPN3, SGCG
muscle cell development (GO:0055001)	-	5.29	0.002	SGCB, TCAP, TTN, BVES, SGCG, DAG1
striated muscle cell development (GO:0055002)	-	5.42	0.001	TTN, SGCB, TCAP, BVES
cardiac cell development (GO:0055006)	-	6.33	0.005	TTN, SGCB, TCAP, BVES
myofibril assembly (GO:0030239)	-	6.43	0.002	TTN, CAPN3, TCAP
sarcomerogenesis (GO:0048769)	-	8.63	0.01	TTN, TCAP
glycosylation (GO:0070085)	-	4.16	0.001	POMT1, POMT2, POMGNT1, POMK, GMPPB, ISPD
muscle fiber development (GO:0048747)	-	5.8	0.011	TTN, SGCB, TCAP
muscle filament sliding (GO:0030049)	-	6.09	0.018	TTN, DES, TCAP
actin filament-based movement (GO:0030048)	-	5.54	0.043	TTN, TRIM32, DES, TCAP
macromolecule glycosylation (GO:0043413)	-	4.2	0.001	POMT1, POMT2, POMGNT1, POMK, GMPPB, ISPD
sarcomere organization (GO:0045214)	-	6.4	0.004	TTN, CAPN3, TCAP
protein O-linked glycosylation (GO:0006493)	-	5.13	0.0	POMGNT1, POMT1, POMT2, POMK, ISPD
mannosylation (GO:0097502)	-	6.26	0.007	POMT1, POMT2, ISPD
cardiac muscle fiber development (GO:0048739)	-	7.65	0.021	TTN, TCAP
actin-mediated cell contraction (GO:0070252)	-	5.88	0.019	TTN, DES, TCAP

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	23	POMT1, TRAPPC11, TCAP, POMT2, SGCG, GMPPB, FKTN, DAG1, SGCB, SGCA, POMK, DYSF, LIMS2, SGCD, TRIM32, POMGNT1, ANO5, CAPN3, TTN, DES, BVES, FKRP, PLEC
intracellular part (GO:0044424)	0.28	22	POMT1, TRAPPC11, TCAP, DES, SGCG, GMPPB, FKTN, DAG1, SGCB, SGCA, POMK, DYSF, LIMS2, SGCD, TRIM32, POMGNT1, ANO5, CAPN3, TTN, POMT2, FKRP, PLEC
intracellular organelle (GO:0043229)	0.51	21	SGCD, ANO5, TTN, POMT2, DYSF, DES, SGCB, SGCG, POMGNT1, CAPN3, POMK, GMPPB, SGCA, FKTN, POMT1, FKRP, TRIM32, TRAPPC11, DAG1, PLEC, LIMS2
organelle (GO:0043226)	0.4	21	SGCD, ANO5, TRAPPC11, TTN, POMT2, DYSF, DES, SGCB, SGCA, POMGNT1, FKRP, POMK, GMPPB, SGCG, FKTN, POMT1, PLEC, CAPN3, DAG1, TRIM32, LIMS2
cytoplasmic part (GO:0044444)	0.82	18	TRAPPC11, FKTN, TCAP, TTN, DES, DYSF, POMT2, POMT1, POMGNT1, FKRP, POMK, GMPPB, LIMS2, ANO5, DAG1, CAPN3, TRIM32, PLEC
membrane (GO:0016020)	0.68	18	SGCD, FKTN, POMT1, DES, DYSF, POMT2, SGCB, BVES, POMGNT1, FKRP, POMK, CAPN3, SGCA, ANO5, DAG1, PLEC, LIMS2, SGCG
membrane-bounded organelle (GO:0043227)	0.47	17	TRAPPC11, ANO5, TTN, POMT2, DYSF, DES, POMT1, POMGNT1, FKRP, TRIM32, GMPPB, PLEC, FKTN, CAPN3, POMK, DAG1, LIMS2
membrane part (GO:0044425)	0.95	15	SGCB, FKTN, POMT1, DYSF, POMT2, SGCD, BVES, POMGNT1, FKRP, POMK, SGCA, ANO5, CAPN3, DAG1, SGCG
intracellular membrane-bounded organelle (GO:0043231)	0.6	15	POMT1, ANO5, TTN, DYSF, POMT2, POMK, POMGNT1, FKRP, DAG1, GMPPB, FKTN, TRAPPC11, CAPN3, TRIM32, LIMS2
organelle part (GO:0044422)	0.79	15	POMT1, ANO5, TCAP, TTN, POMT2, TRIM32, DES, POMK, POMGNT1, FKRP, CAPN3, FKTN, DAG1, DYSF, PLEC
integral component of membrane (GO:0016021)	1.14	14	SGCB, FKTN, POMT1, DYSF, POMT2, SGCD, BVES, POMGNT1, FKRP, POMK, SGCA, ANO5, DAG1, SGCG
intrinsic component of membrane (GO:0031224)	1.13	14	SGCD, FKTN, POMT1, DYSF, POMT2, SGCB, BVES, POMGNT1, FKRP, POMK, SGCA, ANO5, DAG1, SGCG
plasma membrane (GO:0005886)	1.39	13	SGCB, DYSF, DES, SGCD, BVES, FKRP, CAPN3, SGCA, ANO5, DAG1, PLEC, LIMS2, SGCG
intracellular organelle part (GO:0044446)	0.81	12	POMT1, FKTN, TTN, POMT2, TRIM32, DES, POMK, POMGNT1, FKRP, ANO5, DAG1, DYSF
cytoplasm (GO:0005737)	1.01	12	SGCD, TCAP, TTN, TRIM32, DES, SGCB, SGCG, GMPPB, SGCA, CAPN3, DAG1, PLEC
protein complex (GO:0043234)	1.51	11	SGCB, POMT1, TRIM32, POMT2, SGCD, SGCA, TTN, FKRP, SGCG, CAPN3, DAG1
macromolecular complex (GO:0032991)	1.35	11	SGCB, TTN, TRIM32, POMT2, SGCD, SGCA, FKRP, SGCG, POMT1, CAPN3, DAG1
sarcolemma (GO:0042383)	5.2	10	SGCD, DYSF, DES, SGCB, SGCA, FKRP, BVES, DAG1, PLEC, SGCG
non-membrane-bounded organelle (GO:0043228)	1.76	9	SGCD, TTN, DES, SGCB, SGCA, SGCG, CAPN3, DAG1, PLEC
plasma membrane part (GO:0044459)	1.95	9	SGCB, DYSF, SGCD, BVES, FKRP, SGCA, CAPN3, DAG1, SGCG
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	9	SGCD, TTN, DES, SGCB, SGCA, SGCG, CAPN3, DAG1, PLEC
membrane protein complex (GO:0098796)	2.84	8	POMT1, POMT2, SGCD, SGCA, FKRP, SGCB, SGCG, DAG1
cytosol (GO:0005829)	1.68	8	TCAP, TTN, TRIM32, DES, LIMS2, DAG1, CAPN3, PLEC
vesicle (GO:0031982)	1.64	8	POMT1, TTN, DYSF, DES, GMPPB, ANO5, DAG1, PLEC
extracellular region part (GO:0044421)	1.57	8	TTN, DYSF, DES, FKRP, GMPPB, FKTN, DAG1, PLEC
cytoskeleton (GO:0005856)	2.55	7	SGCD, DES, SGCB, SGCA, SGCG, DAG1, PLEC
contractile fiber part (GO:0044449)	4.53	7	TCAP, TTN, TRIM32, DES, CAPN3, DAG1, PLEC
membrane-bounded vesicle (GO:0031988)	1.71	7	POMT1, TTN, DYSF, DES, GMPPB, DAG1, PLEC
extracellular organelle (GO:0043230)	1.89	6	TTN, DYSF, DES, GMPPB, DAG1, PLEC
endoplasmic reticulum (GO:0005783)	2.56	6	POMT1, ANO5, POMT2, POMK, FKRP, FKTN
nucleus (GO:0005634)	1.07	6	TTN, TRIM32, FKTN, DAG1, CAPN3, LIMS2
plasma membrane protein complex (GO:0098797)	3.55	6	SGCD, SGCB, SGCA, FKRP, SGCG, DAG1
extracellular vesicle (GO:1903561)	1.89	6	TTN, DYSF, DES, GMPPB, DAG1, PLEC
cell junction (GO:0030054)	2.75	6	DES, SGCA, LIMS2, DAG1, BVES, PLEC
extracellular exosome (GO:0070062)	1.89	6	TTN, DYSF, DES, GMPPB, DAG1, PLEC
glycoprotein complex (GO:0090665)	7.03	5	SGCD, SGCB, DAG1, FKRP, SGCA
dystroglycan complex (GO:0016011)	8.19	5	SGCD, SGCA, SGCB, DAG1, SGCG
dystrophin-associated glycoprotein complex (GO:0016010)	7.03	5	FKRP, DAG1, SGCB, SGCD, SGCA
Golgi apparatus (GO:0005794)	2.7	4	POMGNT1, FKRP, FKTN, TRAPPC11
organelle membrane (GO:0031090)	1.97	4	POMGNT1, DYSF, FKRP, FKTN
anchoring junction (GO:0070161)	3.61	4	DAG1, DES, PLEC, LIMS2
endoplasmic reticulum membrane (GO:0005789)	2.95	4	POMT1, POMT2, POMK, ANO5
sarcoglycan complex (GO:0016012)	8.01	4	SGCD, SGCA, SGCB, SGCG
endoplasmic reticulum part (GO:0044432)	2.73	4	POMT1, POMT2, POMK, ANO5
adherens junction (GO:0005912)	3.66	4	DAG1, DES, PLEC, LIMS2
cell-cell junction (GO:0005911)	3.85	4	DAG1, DES, SGCA, BVES
intracellular (GO:0005622)	2.37	4	CAPN3, DES, TRIM32, ANO5
Z disc (GO:0030018)	5.11	4	TTN, CAPN3, DES, TCAP
membrane microdomain (GO:0098857)	4.17	3	DAG1, SGCA, BVES
extracellular space (GO:0005615)	2.63	3	DAG1, FKRP, FKTN
bounding membrane of organelle (GO:0098588)	2.39	3	POMGNT1, FKRP, FKTN
membrane region (GO:0098589)	3.95	3	DAG1, SGCA, BVES
Golgi membrane (GO:0000139)	3.28	3	POMGNT1, FKRP, FKTN
Golgi apparatus part (GO:0044431)	3.0	3	POMGNT1, FKRP, FKTN
cytoskeletal part (GO:0044430)	2.49	3	TTN, TRIM32, DES
extracellular region (GO:0005576)	2.18	3	TTN, FKRP, DAG1
contractile fiber (GO:0043292)	5.81	3	CAPN3, DES, PLEC
membrane raft (GO:0045121)	4.18	3	DAG1, SGCA, BVES
cell-substrate adherens junction (GO:0005924)	3.83	3	DAG1, PLEC, LIMS2
focal adhesion (GO:0005925)	3.83	3	DAG1, PLEC, LIMS2
cell-substrate junction (GO:0030055)	3.82	3	DAG1, PLEC, LIMS2
plasma membrane region (GO:0098590)	2.97	2	DAG1, BVES
synapse (GO:0045202)	3.58	2	DAG1, DES
intermediate filament cytoskeleton (GO:0045111)	5.79	2	DES, PLEC
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	POMT1, DYSF
cytoplasmic vesicle (GO:0031410)	2.87	2	POMT1, DYSF
I band (GO:0031674)	6.67	2	TTN, TCAP
muscle myosin complex (GO:0005859)	6.86	2	TTN, TRIM32
T-tubule (GO:0030315)	6.09	2	CAPN3, DYSF
myosin complex (GO:0016459)	5.55	2	TTN, TRIM32
catalytic complex (GO:1902494)	2.9	2	POMT1, POMT2
lamellipodium (GO:0030027)	4.73	2	DAG1, DYSF
cell-cell adherens junction (GO:0005913)	5.81	2	DAG1, DES
intracellular vesicle (GO:0097708)	2.86	2	POMT1, DYSF
transferase complex (GO:1990234)	3.32	2	POMT1, POMT2
cell projection (GO:0042995)	2.47	2	DAG1, DYSF
myofilament (GO:0036379)	7.16	2	TTN, TRIM32
dolichyl-phosphate-mannose-protein mannosyltransferase complex (GO:0031502)	8.42	2	POMT1, POMT2
mannosyltransferase complex (GO:0031501)	7.72	2	POMT1, POMT2
cell projection part (GO:0044463)	2.97	2	DAG1, BVES
myosin II complex (GO:0016460)	6.54	2	TTN, TRIM32
nuclear part (GO:0044428)	1.55	2	TTN, DAG1
costamere (GO:0043034)	6.86	2	DAG1, PLEC

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytoskeleton (GO:0005856)	-	2.55	0.024	SGCD, TCAP, DYSF, DES, SGCB, SGCG, GMPPB, SGCA, CAPN3, DAG1, PLEC
myofilament (GO:0036379)	-	7.16	0.024	TTN, TRIM32
membrane (GO:0016020)	-	0.68	0.011	SGCD, PLEC, FKTN, POMT1, POMT2, DYSF, DES, SGCB, BVES, POMGNT1, FKRP, SGCA, ANO5, CAPN3, POMK, DAG1, LIMS2, SGCG
sarcolemma (GO:0042383)	-	5.2	0.0	SGCB, DYSF, DES, SGCD, SGCA, FKRP, SGCG, CAPN3, DAG1, PLEC
organelle membrane (GO:0031090)	-	1.97	0.014	POMT1, ANO5, TCAP, POMT2, TRIM32, DES, POMK, SGCG, POMGNT1, FKRP, GMPPB, SGCA, FKTN, CAPN3, DAG1, DYSF, PLEC
membrane region (GO:0098589)	-	3.95	0.017	POMT1, TCAP, POMT2, DYSF, DES, SGCA, POMK, CAPN3, SGCG, ANO5, DAG1, TRIM32, PLEC
cytoplasmic part (GO:0044444)	-	0.82	0.02	POMT1, TRAPPC11, TCAP, TTN, DES, TRIM32, POMT2, POMK, POMGNT1, FKRP, FKTN, GMPPB, LIMS2, ANO5, DAG1, CAPN3, DYSF, PLEC
I band (GO:0031674)	-	6.67	0.033	TTN, TCAP
sarcoglycan complex (GO:0016012)	-	8.01	0.0	SGCD, SGCA, SGCB, SGCG
dystrophin-associated glycoprotein complex (GO:0016010)	-	7.03	0.0	SGCD, SGCB, DAG1, FKRP, SGCA
cell-cell adherens junction (GO:0005913)	-	5.81	0.037	DAG1, DES, SGCG
costamere (GO:0043034)	-	6.86	0.033	DAG1, PLEC
plasma membrane (GO:0005886)	-	1.39	0.018	SGCB, DYSF, DES, SGCD, BVES, FKRP, CAPN3, SGCA, ANO5, DAG1, PLEC, LIMS2, SGCG
Z disc (GO:0030018)	-	5.11	0.001	TCAP, TTN, DES, SGCG, CAPN3, DAG1
contractile fiber part (GO:0044449)	-	4.53	0.0	TCAP, TTN, DYSF, DES, SGCG, CAPN3, DAG1, TRIM32, PLEC