Disease table of ADVANCED SLEEP PHASE SYNDROME OMIM ID: PS604348

Gene-disease associations table

GeneAssociated with ADVANCED SLEEP PHASE SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PER3ClinVar, OMIMHGNC link1p36.231PS604348
PER2ClinVar, OMIM, HUMSAVARHGNC link2q37.31PS604348
CSNK1DClinVar, OMIM, HUMSAVARHGNC link17q25.31PS604348

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
PER2YES3SNAI2, MAOA, TWIST10
ARNTLNO9NR1D1, CRY2, CRY1, PER1, BHLHE40, MAOA, PER3, VWF, PER22PER2, PER3
CLOCKNO14NR0B2, CRY2, NR3C1, TPO, VWF, STAR, BHLHE40, PER1, PER3, NR1D1, KAT5, CRY1, CREBBP, PER22PER2, PER3
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PER3YES2CLOCK, ARNTL0
PER2YES3NPAS2, CLOCK, ARNTL0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PER3PER2Yes2CRY2, CSNK1E
PER3CSNK1DNo4ATM, CSNK1E, PER1, PER2
PER2CSNK1DYes4TP53, PML, CSNK1E, MDM2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PER3PER2Yesbinding15SKP1, CRY1, PER1, CLOCK, CSNK1D, CSNK1E, RBX1, BTRC, FBXW11, ARNTL, NPAS2, CRY2, PPARA, CUL1, TIMELESS
PER3CSNK1DYesactivation9CRY1, CRY2, CLOCK, PER1, CSNK1E, BTRC, ARNTL, NPAS2, PER2
PER2CSNK1DYesactivation, binding14PER3, CRY1, CRY2, CLOCK, TP53, CSNK1A1, CSNK1E, BTRC, PER1, ARNTL, NPAS2, GSK3B, UBC, ARNTL2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CSNK1DPER2yes, complexThe core of PER complexes is composed of at least PER1, PER2, PER3, CRY1, CRY2, CSNK1D and/or CSNK1E. [UniProt]
CSNK1DPER3yes, complexThe core of PER complexes is composed of at least PER1, PER2, PER3, CRY1, CRY2, CSNK1D and/or CSNK1E. [UniProt]
PER2PER3yes, complexThe core of PER complexes is composed of at least PER1, PER2, PER3, CRY1, CRY2, CSNK1D and/or CSNK1E. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Circadian rhythmhsa047107.813CSNK1D, PER2, PER3
Circadian entrainmenthsa047136.112PER2, PER3
Herpes simplex infectionhsa051685.082PER2, PER3

NET-GE enrichment

Term New enriched termICP valueGenes
Circadian rhythm (hsa04710) -7.810.0CSNK1D, PER2, PER3
Circadian entrainment (hsa04713) -6.110.01CSNK1D, PER2, PER3
Herpes simplex infection (hsa05168) -5.080.043PER2, PER3
Environmental adaptationNEW5.770.001CSNK1D, PER2, PER3
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Circadian ClockR-HSA-4002537.032CSNK1D, PER2

NET-GE enrichment

Term New enriched termICP valueGenes
Circadian Clock (R-HSA-400253) -7.030.001CSNK1D, PER2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183CSNK1D, PER2, PER3
protein binding (GO:0005515) 0.463CSNK1D, PER2, PER3
organic cyclic compound binding (GO:0097159) 1.052CSNK1D, PER2
heterocyclic compound binding (GO:1901363) 1.062CSNK1D, PER2

NET-GE enrichment

Term New enriched termICP valueGenes
ubiquitin protein ligase binding (GO:0031625) NEW4.170.001CSNK1D, PER2, PER3
small conjugating protein ligase binding (GO:0044389) NEW4.150.001CSNK1D, PER2, PER3
ubiquitin binding (GO:0043130) NEW5.090.011CSNK1D, PER2
small conjugating protein binding (GO:0032182) NEW4.930.015CSNK1D, PER2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
circadian regulation of gene expression (GO:0032922) 5.693CSNK1D, PER2, PER3
regulation of primary metabolic process (GO:0080090) 1.083CSNK1D, PER2, PER3
regulation of metabolic process (GO:0019222) 1.023CSNK1D, PER2, PER3
regulation of cellular metabolic process (GO:0031323) 1.073CSNK1D, PER2, PER3
nucleic acid metabolic process (GO:0090304) 1.463CSNK1D, PER2, PER3
cellular nitrogen compound metabolic process (GO:0034641) 1.223CSNK1D, PER2, PER3
nitrogen compound metabolic process (GO:0006807) 1.133CSNK1D, PER2, PER3
regulation of biological process (GO:0050789) 0.453CSNK1D, PER2, PER3
single-organism process (GO:0044699) 0.483CSNK1D, PER2, PER3
nucleobase-containing compound metabolic process (GO:0006139) 1.353CSNK1D, PER2, PER3
cellular macromolecule metabolic process (GO:0044260) 0.933CSNK1D, PER2, PER3
organic substance metabolic process (GO:0071704) 0.633CSNK1D, PER2, PER3
rhythmic process (GO:0048511) 4.023CSNK1D, PER2, PER3
biological regulation (GO:0065007) 0.393CSNK1D, PER2, PER3
organic cyclic compound metabolic process (GO:1901360) 1.263CSNK1D, PER2, PER3
regulation of gene expression (GO:0010468) 1.373CSNK1D, PER2, PER3
multicellular organismal process (GO:0032501) 1.453CSNK1D, PER2, PER3
circadian rhythm (GO:0007623) 4.793CSNK1D, PER2, PER3
regulation of macromolecule metabolic process (GO:0060255) 1.083CSNK1D, PER2, PER3
cellular process (GO:0009987) 0.263CSNK1D, PER2, PER3
cellular aromatic compound metabolic process (GO:0006725) 1.33CSNK1D, PER2, PER3
regulation of cellular process (GO:0050794) 0.53CSNK1D, PER2, PER3
regulation of circadian rhythm (GO:0042752) 5.093CSNK1D, PER2, PER3
metabolic process (GO:0008152) 0.583CSNK1D, PER2, PER3
heterocycle metabolic process (GO:0046483) 1.313CSNK1D, PER2, PER3
RNA metabolic process (GO:0016070) 1.593CSNK1D, PER2, PER3
primary metabolic process (GO:0044238) 0.693CSNK1D, PER2, PER3
single-multicellular organism process (GO:0044707) 1.783CSNK1D, PER2, PER3
cellular metabolic process (GO:0044237) 0.693CSNK1D, PER2, PER3
macromolecule metabolic process (GO:0043170) 0.833CSNK1D, PER2, PER3
negative regulation of metabolic process (GO:0009892) 1.932PER2, PER3
RNA biosynthetic process (GO:0032774) 1.842PER2, PER3
negative regulation of biosynthetic process (GO:0009890) 2.472PER2, PER3
macromolecular complex subunit organization (GO:0043933) 2.142CSNK1D, PER2
regulation of cellular biosynthetic process (GO:0031326) 1.382PER2, PER3
negative regulation of cellular metabolic process (GO:0031324) 2.012PER2, PER3
cellular biosynthetic process (GO:0044249) 1.372PER2, PER3
negative regulation of gene expression (GO:0010629) 2.482PER2, PER3
cellular macromolecule biosynthetic process (GO:0034645) 1.662PER2, PER3
regulation of signaling (GO:0023051) 1.722CSNK1D, PER2
regulation of cell communication (GO:0010646) 1.732CSNK1D, PER2
organic cyclic compound biosynthetic process (GO:1901362) 1.662PER2, PER3
cellular component organization or biogenesis (GO:0071840) 1.222CSNK1D, PER2
cellular protein metabolic process (GO:0044267) 1.632CSNK1D, PER2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012PER2, PER3
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122PER2, PER3
regulation of protein metabolic process (GO:0051246) 1.932CSNK1D, PER2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62PER2, PER3
cellular component organization (GO:0016043) 1.242CSNK1D, PER2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432PER2, PER3
negative regulation of cellular biosynthetic process (GO:0031327) 2.492PER2, PER3
regulation of macromolecule biosynthetic process (GO:0010556) 1.432PER2, PER3
nucleic acid-templated transcription (GO:0097659) 1.912PER2, PER3
regulation of protein modification process (GO:0031399) 2.322CSNK1D, PER2
negative regulation of biological process (GO:0048519) 1.332PER2, PER3
regulation of biological quality (GO:0065008) 1.682CSNK1D, PER2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472PER2, PER3
heterocycle biosynthetic process (GO:0018130) 1.72PER2, PER3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552PER2, PER3
biosynthetic process (GO:0009058) 1.322PER2, PER3
organic substance biosynthetic process (GO:1901576) 1.342PER2, PER3
regulation of developmental process (GO:0050793) 2.12CSNK1D, PER2
regulation of biosynthetic process (GO:0009889) 1.372PER2, PER3
regulation of nucleic acid-templated transcription (GO:1903506) 1.552PER2, PER3
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712PER2, PER3
negative regulation of RNA biosynthetic process (GO:1902679) 2.72PER2, PER3
macromolecule modification (GO:0043412) 1.732CSNK1D, PER2
protein modification process (GO:0036211) 1.792CSNK1D, PER2
negative regulation of transcription, DNA-templated (GO:0045892) 2.752PER2, PER3
cellular protein modification process (GO:0006464) 1.792CSNK1D, PER2
regulation of multicellular organismal process (GO:0051239) 1.872PER2, PER3
regulation of RNA biosynthetic process (GO:2001141) 1.552PER2, PER3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722PER2, PER3
negative regulation of RNA metabolic process (GO:0051253) 2.662PER2, PER3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462PER2, PER3
regulation of cellular protein metabolic process (GO:0032268) 1.992CSNK1D, PER2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592PER2, PER3
protein metabolic process (GO:0019538) 1.452CSNK1D, PER2
response to stimulus (GO:0050896) 1.222CSNK1D, PER2
regulation of RNA metabolic process (GO:0051252) 1.522PER2, PER3
single-organism cellular process (GO:0044763) 0.652CSNK1D, PER2
response to stress (GO:0006950) 1.82CSNK1D, PER2
macromolecule biosynthetic process (GO:0009059) 1.612PER2, PER3
regulation of transcription, DNA-templated (GO:0006355) 1.562PER2, PER3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242PER2, PER3
transcription, DNA-templated (GO:0006351) 1.912PER2, PER3
aromatic compound biosynthetic process (GO:0019438) 1.72PER2, PER3
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532PER2, PER3
negative regulation of cellular process (GO:0048523) 1.412PER2, PER3
regulation of nitrogen compound metabolic process (GO:0051171) 1.362PER2, PER3

NET-GE enrichment

Term New enriched termICP valueGenes
circadian regulation of gene expression (GO:0032922) -5.690.0CSNK1D, PER2, PER3
circadian rhythm (GO:0007623) -4.790.0CSNK1D, PER2, PER3
rhythmic process (GO:0048511) -4.020.001CSNK1D, PER2, PER3
regulation of circadian rhythm (GO:0042752) -5.090.0CSNK1D, PER2, PER3
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.013CSNK1D, PER2, PER3
intracellular membrane-bounded organelle (GO:0043231) 0.63CSNK1D, PER2, PER3
nucleus (GO:0005634) 1.073CSNK1D, PER2, PER3
cell part (GO:0044464) 0.113CSNK1D, PER2, PER3
intracellular organelle (GO:0043229) 0.513CSNK1D, PER2, PER3
intracellular part (GO:0044424) 0.283CSNK1D, PER2, PER3
membrane-bounded organelle (GO:0043227) 0.473CSNK1D, PER2, PER3
organelle (GO:0043226) 0.43CSNK1D, PER2, PER3
intracellular organelle part (GO:0044446) 0.812CSNK1D, PER2
intracellular non-membrane-bounded organelle (GO:0043232) 1.762CSNK1D, PER2
nucleoplasm (GO:0005654) 1.892CSNK1D, PER2
cytoplasmic part (GO:0044444) 0.822CSNK1D, PER2
non-membrane-bounded organelle (GO:0043228) 1.762CSNK1D, PER2
nuclear part (GO:0044428) 1.552CSNK1D, PER2
perinuclear region of cytoplasm (GO:0048471) 3.352CSNK1D, PER2
organelle part (GO:0044422) 0.792CSNK1D, PER2