Disease table of MUCOPOLYSACCHARIDOSES OMIM ID: PS607014

Gene-disease associations table

GeneAssociated with MUCOPOLYSACCHARIDOSES inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ARSBClinVar, OMIM, HUMSAVARHGNC link5q14.11PS607014
GNPTABClinVarHGNC link12q23.23252500, 252600, PS607014
HYAL1ClinVar, OMIM, HUMSAVARHGNC link3p21.311PS607014
GALNSClinVar, OMIM, HUMSAVARHGNC link16q24.31PS607014
IDSClinVar, OMIM, HUMSAVARHGNC linkXq281PS607014
GLB1ClinVar, OMIM, HUMSAVARHGNC link3p22.34230600, PS607014, 230650, 230500
IDUAClinVar, OMIM, HUMSAVARHGNC link4p16.31PS607014
HGSNATClinVar, OMIM, HUMSAVARHGNC link8p11.212PS607014, PS268000
SGSHClinVar, OMIM, HUMSAVARHGNC link17q25.31PS607014
NAGLUClinVar, OMIM, HUMSAVARHGNC link17q21.22PS118220, PS607014
GUSBClinVar, OMIM, HUMSAVARHGNC link7q11.212236750, PS607014

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22NAGLU, SGSH
3p22GLB1, HYAL1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
3p2GLB1, HYAL1
17q2NAGLU, SGSH
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
172NAGLU, SGSH
32GLB1, HYAL1
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HYAL1YES4SP1, NFKB1, EGR1, RELA0
GUSBYES1TFAP2A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ARSBGALNSNo3PLAUR, NAAA, PTPRK
ARSBSGSHNo3PLAUR, NAAA, SIAE
ARSBNAGLUNo3PLAUR, NAAA, SUSD4
GALNSIDSYes1TAZ
GALNSGLB1No1NEU1
GALNSSGSHNo2PLAUR, NAAA
GALNSNAGLUNo3PLAUR, NAAA, TAZ
GALNSGUSBNo2IDS, TAZ
IDSNAGLUNo1TAZ
IDSGUSBYes1TAZ
GLB1SGSHNo1FBXO6
GLB1NAGLUNo1FBXO6
GLB1GUSBNo1FBXO6
SGSHNAGLUNo3PLAUR, NAAA, FBXO6
SGSHGUSBNo2TMEM25, FBXO6
NAGLUGUSBNo2TAZ, FBXO6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
GALNSGLB1YesGALNS-lysosomal hydrolase 1.27 MDa complex2CTSA, NEU1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Lysosomehsa041425.7811IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
Metabolic pathwayshsa011002.4910IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
Glycosaminoglycan degradationhsa005318.4510IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT

NET-GE enrichment

Term New enriched termICP valueGenes
Global and overview mapsNEW2.470.001IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Lysosome (hsa04142) -5.780.0IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
MetabolismNEW2.060.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Cellular ProcessesNEW2.220.0IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
Metabolic pathways (hsa01100) -2.490.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Transport and catabolismNEW3.490.0IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
Glycan biosynthesis and metabolismNEW4.780.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Glycosaminoglycan degradation (hsa00531) -8.450.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of carbohydratesR-HSA-713874.9310IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
MucopolysaccharidosesR-HSA-22062819.5210IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Diseases of carbohydrate metabolismR-HSA-56630848.2810IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
Diseases of metabolismR-HSA-56689146.5710IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
MetabolismR-HSA-14307282.3410IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Glycosaminoglycan metabolismR-HSA-16303166.0410IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
DiseaseR-HSA-16436853.3310IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
HS-GAG degradationR-HSA-20240968.527IDUA, IDS, GUSB, NAGLU, SGSH, GLB1, HGSNAT
Heparan sulfate/heparin (HS-GAG) metabolismR-HSA-16380917.27IDUA, IDS, GUSB, NAGLU, SGSH, GLB1, HGSNAT
CS/DS degradationR-HSA-20241019.184IDS, IDUA, ARSB, HYAL1
Chondroitin sulfate/dermatan sulfate metabolismR-HSA-17931857.344IDS, IDUA, ARSB, HYAL1
Keratan sulfate degradationR-HSA-20228579.282GALNS, GLB1
Glycosphingolipid metabolismR-HSA-16606627.622GLB1, ARSB
Keratan sulfate/keratin metabolismR-HSA-16380747.892GALNS, GLB1
Sphingolipid metabolismR-HSA-4281576.792GLB1, ARSB
Metabolism of proteinsR-HSA-3924993.412GLB1, ARSB
Hyaluronan metabolismR-HSA-21428458.982GUSB, HYAL1
Metabolism of lipids and lipoproteinsR-HSA-5568333.792GLB1, ARSB
Post-translational protein modificationR-HSA-5975924.542GLB1, ARSB
Hyaluronan uptake and degradationR-HSA-21609169.42GUSB, HYAL1

NET-GE enrichment

Term New enriched termICP valueGenes
Mucopolysaccharidoses (R-HSA-2206281) -9.520.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Heparan sulfate/heparin (HS-GAG) metabolism (R-HSA-1638091) -7.20.0IDUA, IDS, GUSB, NAGLU, SGSH, GLB1, HGSNAT
Metabolism (R-HSA-1430728) -2.340.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Disease (R-HSA-1643685) -3.330.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
Keratan sulfate degradation (R-HSA-2022857) -9.280.007GALNS, GLB1
CS/DS degradation (R-HSA-2024101) -9.180.0IDS, IDUA, ARSB, HYAL1
Glycosphingolipid metabolism (R-HSA-1660662) -7.620.041GLB1, ARSB
Metabolism of carbohydrates (R-HSA-71387) -4.930.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Keratan sulfate/keratin metabolism (R-HSA-1638074) -7.890.028GALNS, GLB1
Chondroitin sulfate/dermatan sulfate metabolism (R-HSA-1793185) -7.340.0IDS, IDUA, ARSB, HYAL1
Hyaluronan metabolism (R-HSA-2142845) -8.980.006GUSB, HYAL1
Glycosaminoglycan metabolism (R-HSA-1630316) -6.040.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
Hyaluronan uptake and degradation (R-HSA-2160916) -9.40.003GUSB, HYAL1
HS-GAG degradation (R-HSA-2024096) -8.520.0IDUA, IDS, GUSB, NAGLU, SGSH, GLB1, HGSNAT
Diseases of carbohydrate metabolism (R-HSA-5663084) -8.280.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
Diseases of metabolism (R-HSA-5668914) -6.570.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.0511IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
hydrolase activity (GO:0016787) 1.99IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
binding (GO:0005488) 0.189IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, GLB1
cation binding (GO:0043169) 1.45IDS, GNPTAB, SGSH, GALNS, ARSB
hydrolase activity, acting on glycosyl bonds (GO:0016798) 4.915GLB1, IDUA, HYAL1, NAGLU, GUSB
ion binding (GO:0043167) 1.365IDS, GNPTAB, SGSH, GALNS, ARSB
protein binding (GO:0005515) 0.465GLB1, GNPTAB, IDUA, HYAL1, GUSB
hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) 5.145GLB1, IDUA, HYAL1, NAGLU, GUSB
metal ion binding (GO:0046872) 1.415IDS, GNPTAB, SGSH, GALNS, ARSB
hydrolase activity, acting on ester bonds (GO:0016788) 3.14IDS, GALNS, SGSH, ARSB
sulfuric ester hydrolase activity (GO:0008484) 6.914IDS, GALNS, SGSH, ARSB
transferase activity (GO:0016740) 1.953GNPTAB, HGSNAT, HYAL1
N-acetylgalactosamine-4-sulfatase activity (GO:0003943) 9.052GALNS, ARSB
receptor binding (GO:0005102) 2.432IDUA, GUSB
hexosaminidase activity (GO:0015929) 7.032HYAL1, NAGLU

NET-GE enrichment

Term New enriched termICP valueGenes
hydrolase activity (GO:0016787) -1.90.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
hydrolase activity, acting on glycosyl bonds (GO:0016798) -4.910.0GLB1, IDUA, HYAL1, NAGLU, GUSB
hexosaminidase activity (GO:0015929) -7.030.007HYAL1, NAGLU
hydrolase activity, acting on ester bonds (GO:0016788) -3.10.043IDS, GALNS, SGSH, ARSB
catalytic activity (GO:0003824) -1.050.0IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
sulfuric ester hydrolase activity (GO:0008484) -6.910.0IDS, GALNS, SGSH, ARSB
hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) -5.140.0GLB1, IDUA, HYAL1, NAGLU, GUSB
N-acetylgalactosamine-4-sulfatase activity (GO:0003943) -9.050.0GALNS, ARSB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic substance metabolic process (GO:0071704) 0.6311IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
metabolic process (GO:0008152) 0.5811IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
organic substance catabolic process (GO:1901575) 2.4510IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
glycosaminoglycan metabolic process (GO:0030203) 4.6710IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
organonitrogen compound catabolic process (GO:1901565) 3.9110IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
carbohydrate derivative catabolic process (GO:1901136) 4.6110IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
carbohydrate derivative metabolic process (GO:1901135) 3.0710IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
cellular process (GO:0009987) 0.2610IDUA, ARSB, IDS, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
glycosaminoglycan catabolic process (GO:0006027) 5.6210IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
nitrogen compound metabolic process (GO:0006807) 1.1310IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
catabolic process (GO:0009056) 2.3810IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
aminoglycan metabolic process (GO:0006022) 4.6210IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
organonitrogen compound metabolic process (GO:1901564) 2.3210IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
macromolecule metabolic process (GO:0043170) 0.8310IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
aminoglycan catabolic process (GO:0006026) 5.5110IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
macromolecule catabolic process (GO:0009057) 3.010IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
cellular metabolic process (GO:0044237) 0.698IDUA, ARSB, IDS, SGSH, GALNS, HYAL1, GNPTAB, GLB1
mucopolysaccharide metabolic process (GO:1903510) 5.057IDUA, ARSB, IDS, GUSB, HYAL1, GALNS, GLB1
cellular catabolic process (GO:0044248) 2.626IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
primary metabolic process (GO:0044238) 0.696IDUA, ARSB, GUSB, HYAL1, GNPTAB, GLB1
sulfur compound metabolic process (GO:0006790) 3.876IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
single-organism process (GO:0044699) 0.486IDUA, ARSB, HYAL1, GNPTAB, NAGLU, GLB1
sulfur compound catabolic process (GO:0044273) 6.176IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
carbohydrate metabolic process (GO:0005975) 3.265GLB1, GNPTAB, IDUA, HYAL1, GUSB
single-organism cellular process (GO:0044763) 0.655ARSB, GLB1, GNPTAB, IDUA, NAGLU
chondroitin sulfate catabolic process (GO:0030207) 7.094IDS, IDUA, ARSB, HYAL1
single-organism metabolic process (GO:0044710) 1.634GNPTAB, IDUA, GLB1, ARSB
chondroitin sulfate metabolic process (GO:0030204) 6.024IDS, IDUA, ARSB, HYAL1
cellular component organization (GO:0016043) 1.244ARSB, GNPTAB, HGSNAT, NAGLU
cellular component organization or biogenesis (GO:0071840) 1.224ARSB, GNPTAB, HGSNAT, NAGLU
developmental process (GO:0032502) 1.363ARSB, HYAL1, NAGLU
vacuole organization (GO:0007033) 4.673GNPTAB, ARSB, NAGLU
anatomical structure development (GO:0048856) 1.583ARSB, HYAL1, NAGLU
cellular carbohydrate metabolic process (GO:0044262) 4.743GLB1, GNPTAB, IDUA
organelle organization (GO:0006996) 2.023GNPTAB, ARSB, NAGLU
transport (GO:0006810) 1.513GNPTAB, HGSNAT, ARSB
lytic vacuole organization (GO:0080171) 6.023GNPTAB, ARSB, NAGLU
lysosome organization (GO:0007040) 6.023GNPTAB, ARSB, NAGLU
single-organism carbohydrate metabolic process (GO:0044723) 3.423GLB1, GNPTAB, IDUA
establishment of localization (GO:0051234) 1.483GNPTAB, HGSNAT, ARSB
localization (GO:0051179) 1.43GNPTAB, HGSNAT, ARSB
positive regulation of cellular component organization (GO:0051130) 2.682ARSB, HYAL1
keratan sulfate catabolic process (GO:0042340) 7.242GALNS, GLB1
oligosaccharide metabolic process (GO:0009311) 5.542GNPTAB, IDUA
regulation of cellular component organization (GO:0051128) 2.012ARSB, HYAL1
lysosomal transport (GO:0007041) 5.512HGSNAT, ARSB
response to chemical (GO:0042221) 1.982ARSB, HYAL1
anatomical structure morphogenesis (GO:0009653) 2.532NAGLU, HYAL1
regulation of biological process (GO:0050789) 0.452ARSB, HYAL1
membrane lipid metabolic process (GO:0006643) 4.512GLB1, ARSB
cellular macromolecule metabolic process (GO:0044260) 0.932SGSH, ARSB
positive regulation of multicellular organismal process (GO:0051240) 2.492ARSB, HYAL1
keratan sulfate metabolic process (GO:0042339) 6.232GALNS, GLB1
biological regulation (GO:0065007) 0.392ARSB, HYAL1
glycosphingolipid metabolic process (GO:0006687) 5.492GLB1, ARSB
positive regulation of biological process (GO:0048518) 1.22ARSB, HYAL1
regulation of multicellular organismal development (GO:2000026) 2.312ARSB, HYAL1
glycolipid metabolic process (GO:0006664) 5.012GLB1, ARSB
sphingolipid metabolic process (GO:0006665) 4.792GLB1, ARSB
embryonic morphogenesis (GO:0048598) 3.722HYAL1, NAGLU
liposaccharide metabolic process (GO:1903509) 4.982GLB1, ARSB
hyaluronan metabolic process (GO:0030212) 6.292GUSB, HYAL1
regulation of cell migration (GO:0030334) 3.232ARSB, HYAL1
hyaluronan catabolic process (GO:0030214) 7.022GUSB, HYAL1
lipid metabolic process (GO:0006629) 2.682GLB1, ARSB
regulation of developmental process (GO:0050793) 2.12ARSB, HYAL1
regulation of cellular process (GO:0050794) 0.52ARSB, HYAL1
single-organism developmental process (GO:0044767) 1.492NAGLU, HYAL1
regulation of cellular component movement (GO:0051270) 3.082ARSB, HYAL1
vacuolar transport (GO:0007034) 4.182HGSNAT, ARSB
regulation of multicellular organismal process (GO:0051239) 1.872ARSB, HYAL1
response to pH (GO:0009268) 5.972ARSB, HYAL1
cellular lipid metabolic process (GO:0044255) 2.922GLB1, ARSB
regulation of localization (GO:0032879) 1.942ARSB, HYAL1
response to organic substance (GO:0010033) 2.22ARSB, HYAL1
response to abiotic stimulus (GO:0009628) 2.82ARSB, HYAL1
regulation of locomotion (GO:0040012) 3.122ARSB, HYAL1
regulation of epithelial cell migration (GO:0010632) 4.622ARSB, HYAL1
response to external stimulus (GO:0009605) 2.552ARSB, HYAL1
positive regulation of developmental process (GO:0051094) 2.772ARSB, HYAL1
response to stimulus (GO:0050896) 1.222ARSB, HYAL1
regulation of cell motility (GO:2000145) 3.162ARSB, HYAL1
system development (GO:0048731) 2.922ARSB, NAGLU
positive regulation of cellular process (GO:0048522) 1.32ARSB, HYAL1

NET-GE enrichment

Term New enriched termICP valueGenes
chondroitin sulfate catabolic process (GO:0030207) -7.090.0IDS, IDUA, ARSB, HYAL1
chondroitin sulfate metabolic process (GO:0030204) -6.020.0IDS, IDUA, ARSB, HYAL1
glycosaminoglycan metabolic process (GO:0030203) -4.670.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
nitrogen compound metabolic process (GO:0006807) -1.130.014IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
small molecule metabolic process (GO:0044281) NEW2.380.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
lysosome organization (GO:0007040) -6.020.0ARSB, GNPTAB, IDUA, NAGLU
single-organism catabolic process (GO:0044712) NEW3.210.001IDUA, ARSB, IDS, GUSB, HYAL1, GALNS, GLB1
single-organism metabolic process (GO:0044710) -1.630.003IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
keratan sulfate metabolic process (GO:0042339) -6.230.041GALNS, GLB1
hyaluronan metabolic process (GO:0030212) -6.290.041GUSB, HYAL1
hyaluronan catabolic process (GO:0030214) -7.020.017GUSB, HYAL1
organic substance catabolic process (GO:1901575) -2.450.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
oxoacid metabolic process (GO:0043436) NEW3.120.003IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
carbohydrate metabolic process (GO:0005975) -3.260.0IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
catabolic process (GO:0009056) -2.380.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
macromolecule catabolic process (GO:0009057) -3.00.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
organonitrogen compound catabolic process (GO:1901565) -3.910.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
vacuole organization (GO:0007033) -4.670.0ARSB, GNPTAB, IDUA, NAGLU
keratan sulfate catabolic process (GO:0042340) -7.240.012GALNS, GLB1
organonitrogen compound metabolic process (GO:1901564) -2.320.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
sulfur compound catabolic process (GO:0044273) -6.170.0IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
organic acid metabolic process (GO:0006082) NEW3.010.003IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
carbohydrate derivative catabolic process (GO:1901136) -4.610.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
carbohydrate derivative metabolic process (GO:1901135) -3.070.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
sulfur compound metabolic process (GO:0006790) -3.870.0IDUA, ARSB, IDS, HYAL1, GALNS, GLB1
aminoglycan metabolic process (GO:0006022) -4.620.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
response to pH (GO:0009268) -5.970.032ARSB, HYAL1
aminoglycan catabolic process (GO:0006026) -5.510.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
glycosaminoglycan catabolic process (GO:0006027) -5.620.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.611IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
cell part (GO:0044464) 0.1111IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
cytoplasmic part (GO:0044444) 0.8211IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
intracellular organelle part (GO:0044446) 0.8111IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
intracellular organelle (GO:0043229) 0.5111IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
intracellular part (GO:0044424) 0.2811IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
membrane-bounded organelle (GO:0043227) 0.4711IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
organelle (GO:0043226) 0.411IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
organelle part (GO:0044422) 0.7911IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
lysosome (GO:0005764) 3.8910IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
vacuole (GO:0005773) 2.9210IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
vacuolar part (GO:0044437) 3.2610IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
lytic vacuole (GO:0000323) 3.8910IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1, HGSNAT
intracellular organelle lumen (GO:0070013) 3.059IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
lysosomal lumen (GO:0043202) 5.329IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
vacuolar lumen (GO:0005775) 5.069IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
membrane-enclosed lumen (GO:0031974) 3.059IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
organelle lumen (GO:0043233) 3.059IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
extracellular organelle (GO:0043230) 1.898IDUA, ARSB, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
extracellular exosome (GO:0070062) 1.898IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
membrane-bounded vesicle (GO:0031988) 1.718IDUA, ARSB, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
extracellular vesicle (GO:1903561) 1.898IDUA, ARSB, GUSB, GALNS, NAGLU, SGSH, HYAL1, GLB1
extracellular region part (GO:0044421) 1.578IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
vesicle (GO:0031982) 1.648IDUA, ARSB, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
Golgi apparatus (GO:0005794) 2.73GNPTAB, GLB1, ARSB
membrane (GO:0016020) 0.683GNPTAB, HGSNAT, GUSB
cytoplasm (GO:0005737) 1.012GLB1, HYAL1
organelle membrane (GO:0031090) 1.972GNPTAB, HGSNAT
cytoplasmic vesicle (GO:0031410) 2.872IDUA, HYAL1
integral component of membrane (GO:0016021) 1.142GNPTAB, HGSNAT
intracellular vesicle (GO:0097708) 2.862IDUA, HYAL1
membrane part (GO:0044425) 0.952GNPTAB, HGSNAT
bounding membrane of organelle (GO:0098588) 2.392GNPTAB, HGSNAT
intrinsic component of membrane (GO:0031224) 1.132GNPTAB, HGSNAT
extracellular space (GO:0005615) 2.632GUSB, HYAL1

NET-GE enrichment

Term New enriched termICP valueGenes
intracellular organelle part (GO:0044446) -0.810.001IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
lysosomal lumen (GO:0043202) -5.320.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
lytic vacuole (GO:0000323) -3.890.0ARSB, GLB1, HYAL1, IDUA, NAGLU
vesicle (GO:0031982) -1.640.003IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
organelle lumen (GO:0043233) -3.050.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
vacuole (GO:0005773) -2.920.0NAGLU, IDUA, GLB1, HYAL1, ARSB
membrane-enclosed lumen (GO:0031974) -3.050.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
membrane-bounded vesicle (GO:0031988) -1.710.003IDUA, ARSB, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
lysosome (GO:0005764) -3.890.0ARSB, GLB1, IDUA, NAGLU, HYAL1
intracellular organelle lumen (GO:0070013) -3.050.0IDUA, ARSB, IDS, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
cytoplasmic part (GO:0044444) -0.820.002IDUA, ARSB, IDS, GUSB, SGSH, GALNS, NAGLU, GNPTAB, HYAL1, GLB1, HGSNAT
vacuolar part (GO:0044437) -3.260.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1, HGSNAT
vacuolar lumen (GO:0005775) -5.060.0IDUA, ARSB, IDS, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
extracellular organelle (GO:0043230) -1.890.001IDUA, ARSB, GUSB, SGSH, NAGLU, GALNS, HYAL1, GLB1
extracellular membrane-bounded organelle (GO:0065010) NEW8.70.001IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
extracellular region part (GO:0044421) -1.570.008IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1
organelle part (GO:0044422) -0.790.001IDUA, ARSB, IDS, GUSB, SGSH, GALNS, HYAL1, GNPTAB, NAGLU, GLB1, HGSNAT
extracellular vesicular exosome (GO:0070062) -1.890.001IDUA, ARSB, GUSB, SGSH, HYAL1, GALNS, NAGLU, GLB1