Disease table of COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY OMIM ID: PS609060

Gene-disease associations table

GeneAssociated with COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FARS2ClinVar, OMIM, HUMSAVARHGNC link6p25.11PS609060
EARS2ClinVar, OMIM, HUMSAVARHGNC link16p12.21PS609060
PNPT1ClinVar, OMIM, HUMSAVARHGNC link2p16.12PS609060, PS220290
CARS2ClinVar, OMIM, HUMSAVARHGNC link13q341PS609060
MRPS16ClinVar, OMIMHGNC link10q22.21PS609060
SFXN4ClinVar, OMIMHGNC link10q26.111PS609060
LYRM4ClinVar, OMIM, HUMSAVARHGNC link6p25.11PS609060
ELAC2ClinVar, OMIM, HUMSAVARHGNC link17p122PS609060, 614731
TSFMClinVar, OMIM, HUMSAVARHGNC link12q14.11PS609060
ATP5A1ClinVar, OMIM, HUMSAVARHGNC link18q21.12PS609060, 615228
MARS2ClinVar, OMIM, HUMSAVARHGNC link2q33.12PS609060, PS108600
VARS2ClinVar, OMIM, HUMSAVARHGNC link6p21.331PS609060
TRMT5OMIM, HUMSAVARHGNC link14q23.11PS609060
MTO1ClinVar, OMIM, HUMSAVARHGNC link6q131PS609060
AARS2ClinVar, OMIM, HUMSAVARHGNC link6p21.12PS609060, 615889
TARS2ClinVar, OMIM, HUMSAVARHGNC link1q21.21PS609060
NARS2ClinVar, OMIM, HUMSAVARHGNC link11q14.12PS609060, 256000
TXN2ClinVar, OMIMHGNC link22q12.31PS609060
SLC25A26ClinVar, OMIMHGNC link3p14.11PS609060
MRPL3ClinVar, OMIM, HUMSAVARHGNC link3q22.11PS609060
GTPBP3ClinVar, OMIM, HUMSAVARHGNC link19p13.111PS609060
RMND1ClinVar, OMIM, HUMSAVARHGNC link6q25.11PS609060
MTFMTClinVar, OMIM, HUMSAVARHGNC link15q22.312PS609060, 256000
C12orf65OMIMHGNC link12q24.312PS609060, PS303350
GFM1ClinVar, OMIM, HUMSAVARHGNC link3q25.321PS609060
MRPS22ClinVar, OMIM, HUMSAVARHGNC link3q231PS609060
MRPL44ClinVar, OMIM, HUMSAVARHGNC link2q36.11PS609060
AIFM1OMIM, HUMSAVARHGNC linkXq26.14PS609060, PS304500, PS609129, PS118220
TUFMClinVar, OMIM, HUMSAVARHGNC link16p11.21PS609060

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
6p25.12FARS2, LYRM4
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
6p212AARS2, VARS2
6p252FARS2, LYRM4
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
2q32MARS2, MRPL44
6p24AARS2, FARS2, VARS2, LYRM4
16p12EARS2, TUFM
3q23GFM1, MRPS22, MRPL3
10q22MRPS16, SFXN4
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2q2MARS2, MRPL44
3q3GFM1, MRPS22, MRPL3
6q2MTO1, RMND1
6p4AARS2, FARS2, VARS2, LYRM4
12q2TSFM, C12orf65
10q2MRPS16, SFXN4
16p2EARS2, TUFM
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102MRPS16, SFXN4
122TSFM, C12orf65
162EARS2, TUFM
34SLC25A26, GFM1, MRPL3, MRPS22
23PNPT1, MARS2, MRPL44
66MTO1, FARS2, AARS2, VARS2, RMND1, LYRM4
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ATP5A1YES1USF20
TXN2YES1RUNX30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FARS2PNPT1No2NXF1, ICT1
FARS2MRPS16No1ICT1
FARS2SFXN4No1NXF1
FARS2ATP5A1No5NXF1, CUL3, HNRNPA1, ISG15, ICT1
FARS2VARS2No2CMTM5, ICT1
FARS2TARS2No2CUL3, ICT1
FARS2TXN2No2KRT40, AGTRAP
FARS2MRPL3No2HNRNPA1, ICT1
FARS2MRPS22No5SHMT2, ZC3H3, HNRNPA1, CUL3, ICT1
FARS2MRPL44No3HNRNPA1, CUL3, ICT1
FARS2AIFM1No4TOMM40, CUL3, NXF1, ISG15
FARS2TUFMNo3CMTM5, CUL3, ICT1
EARS2PNPT1No1NTRK1
EARS2ELAC2No1NTRK1
EARS2ATP5A1No1NTRK1
EARS2AARS2No1NTRK1
EARS2TARS2No1NTRK1
EARS2MRPL3No1NTRK1
EARS2GFM1No1NTRK1
EARS2MRPS22No1NTRK1
EARS2MRPL44No1NTRK1
EARS2AIFM1No1NTRK1
EARS2TUFMNo1NTRK1
PNPT1MRPS16No1ICT1
PNPT1SFXN4No1NXF1
PNPT1ELAC2No1NTRK1
PNPT1ATP5A1No5NXF1, NTRK1, EIF4A1, PTBP1, ICT1
PNPT1VARS2No1ICT1
PNPT1AARS2No1NTRK1
PNPT1TARS2No2NTRK1, ICT1
PNPT1MRPL3No2NTRK1, ICT1
PNPT1GFM1No1NTRK1
PNPT1MRPS22No3NTRK1, GRSF1, ICT1
PNPT1MRPL44No2NTRK1, ICT1
PNPT1AIFM1No2NTRK1, NXF1
PNPT1TUFMNo4NTRK1, SIRT7, PTBP1, ICT1
CARS2TSFMNo1OXLD1
CARS2ATP5A1No1EGFR
CARS2AARS2No1OXLD1
CARS2TARS2No1EGFR
CARS2NARS2No1OXLD1
CARS2AIFM1No1EGFR
MRPS16ATP5A1No3HNRNPU, CAND1, ICT1
MRPS16VARS2No1ICT1
MRPS16TARS2No1ICT1
MRPS16MRPL3No3MRPS9, CAND1, ICT1
MRPS16MTFMTNo1ELAVL1
MRPS16MRPS22No7TRMT10B, ICT1, MRPS26, CAND1, MRPS2, MRPS9, MRPS25
MRPS16MRPL44No3HNRNPU, MPV17, ICT1
MRPS16AIFM1No1CAND1
MRPS16TUFMNo1ICT1
SFXN4ATP5A1No2NXF1, MOV10
SFXN4TXN2No1MOV10
SFXN4AIFM1No2NXF1, ABCE1
ELAC2ATP5A1No1NTRK1
ELAC2AARS2No1NTRK1
ELAC2TARS2No1NTRK1
ELAC2MRPL3No2NTRK1, MRPS30
ELAC2GFM1No1NTRK1
ELAC2MRPS22No2NTRK1, COPS5
ELAC2MRPL44No2NTRK1, MRPS30
ELAC2AIFM1No2NTRK1, COPS5
ELAC2TUFMNo2NTRK1, COPS5
TSFMAARS2No1OXLD1
TSFMNARS2No2OXLD1, SLC25A41
TSFMMRPL3No1C1QBP
TSFMMRPS22No1C1QBP
TSFMMRPL44No1C1QBP
TSFMTUFMNo1C1QBP
ATP5A1MARS2No1APP
ATP5A1VARS2No1ICT1
ATP5A1AARS2No3NTRK1, YWHAQ, CCDC8
ATP5A1TARS2No4NTRK1, CUL3, EGFR, ICT1
ATP5A1TXN2No3MLH1, HSPA1L, MOV10
ATP5A1MRPL3No6HNRNPA1, ICT1, RPS3, CAND1, NTRK1, APP
ATP5A1MTFMTNo1APP
ATP5A1C12orf65No2APP, CDK2
ATP5A1GFM1No3NTRK1, ADRB2, MAPK13
ATP5A1MRPS22No16HNRNPA1, TARDBP, ICT1, CUL1, CUL3, PARK2, CAND1, RPS6KB2, ERBB3, TP53, BTK, NPM1, NTRK1, UBL4A, UBC, SOX2
ATP5A1MRPL44No8HNRNPA1, ICT1, TARDBP, ILK, NPM1, HNRNPU, NTRK1, CUL3
ATP5A1AIFM1No20STAU1, ADRB2, FBXO6, ILK, MLH1, HSPA1A, PARK2, CUL5, CAND1, RPS6KB2, TMEM63B, CCDC8, EGFR, NTRK1, ERBB3, NXF1, ISG15, CUL3, CUL1, PAN2
ATP5A1TUFMNo36FN1, UQCRC2, HUWE1, CKAP5, ADRB2, RPS3, CCDC8, PAN2, RPN1, PTBP1, ESRRB, RPS15A, VCAM1, SKI, ERBB3, FBXO6, RPS6KB2, HDAC5, SPRTN, OBSL1, HSP90AA1, UBC, PTEN, NPM1, UBL4A, CUL5, ICT1, CDK2, FUS, LMAN1, PARK2, CD81, CUL7, NTRK1, MCM2, CUL3
MARS2AARS2No1MRPL4
MARS2MRPL3No2MRPL4, APP
MARS2MTFMTNo1APP
MARS2C12orf65No1APP
MARS2MRPL44No1MRPL4
MARS2TUFMNo1MRPL4
VARS2TARS2No1ICT1
VARS2MRPL3No1ICT1
VARS2MRPS22No1ICT1
VARS2MRPL44No2ICT1, ABI2
VARS2TUFMNo2CMTM5, ICT1
AARS2TARS2No1NTRK1
AARS2NARS2No1OXLD1
AARS2MRPL3No3FOXB1, NTRK1, MRPL4
AARS2GFM1No1NTRK1
AARS2MRPS22No3NTRK1, RNF2, FBXW11
AARS2MRPL44No2NTRK1, MRPL4
AARS2AIFM1No4NTRK1, BMI1, RNF2, CCDC8
AARS2TUFMNo5NTRK1, BMI1, MRPL4, RNF2, CCDC8
TARS2MRPL3No2NTRK1, ICT1
TARS2GFM1No1NTRK1
TARS2MRPS22No3NTRK1, CUL3, ICT1
TARS2MRPL44No3NTRK1, CUL3, ICT1
TARS2AIFM1No3NTRK1, CUL3, EGFR
TARS2TUFMNo3NTRK1, CUL3, ICT1
TXN2MRPL3No1MRPL23
TXN2RMND1No1FAM9B
TXN2MRPL44No2ILF3, VIM
TXN2AIFM1No1MLH1
TXN2TUFMNo6RPS16, RPL8, MRPL23, RPL9, WDR12, FAM9B
MRPL3MTFMTNo1APP
MRPL3C12orf65No1APP
MRPL3GFM1No2NTRK1, TUFM
MRPL3MRPS22No8MRPS27, HNRNPA1, ICT1, RPS8, CAND1, NTRK1, C1QBP, MRPS9
MRPL3MRPL44No19RPS8, MRPL37, HNRNPA1, MRPL13, ICT1, MRPL1, MRPL50, MRPL9, MRPL28, MRPL42, MRPL4, MRPL38, MRPL47, MRPL19, NTRK1, MRPS30, MRPL41, C1QBP, MRPL39
MRPL3AIFM1No2NTRK1, CAND1
MRPL3TUFMYes11MRPL18, ICT1, RPS8, MRPL1, RPS5, RPS3, MRPL23, MRPL4, MRPL17, NTRK1, C1QBP
RMND1TUFMNo1FAM9B
MTFMTC12orf65No1APP
C12orf65TUFMNo1CDK2
GFM1MRPS22No1NTRK1
GFM1MRPL44No1NTRK1
GFM1AIFM1No2NTRK1, ADRB2
GFM1TUFMYes4NTRK1, ADRB2, RPL23A, MRPS7
MRPS22MRPL44No11HNRNPA1, TARDBP, ICT1, RPS8, GBA2, BTRC, NPM1, NFKBIL1, NTRK1, C1QBP, CUL3
MRPS22AIFM1No10CUL1, PARK2, RNF2, RPS6KB2, ERBB3, CAND1, NTRK1, COPS5, CUL3, KSR1
MRPS22TUFMNo16SMURF1, ICT1, RPS8, PARK2, RPL6, NTRK1, ERBB3, RNF2, MRPS5, NPM1, UBC, COPS5, C1QBP, RPS6KB2, UBL4A, CUL3
MRPL44AIFM1No5NTRK1, ILK, SHC1, CUL3, SETDB1
MRPL44TUFMNo9ICT1, RPS8, MRPL1, MRPL4, NPM1, MRPL24, NTRK1, C1QBP, CUL3
AIFM1TUFMNo16ADRB2, RNF2, ASB12, CUL3, PARK2, CUL5, CCDC8, RPS6KB2, ERBB3, SUZ12, FBXO6, NTRK1, COPS5, BMI1, CUL2, PAN2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
FARS2EARS2No-0
FARS2CARS2No-0
FARS2MARS2No-3IARS2, AIMP1, IARS
FARS2NARS2No-2IARS2, IARS
FARS2TUFMNo-2HSPD1, CCT7
EARS2CARS2No-0
EARS2MARS2Yesbinding1RARS2
EARS2NARS2No-2MARS2, MARS
PNPT1TUFMNo-1CWC22
CARS2MARS2No-0
MRPS16MRPL3No-12MRPS5, RPS11, RPS16, RPS15A, RPS5, MRPS7, MRPS15, RPS2, RPS13, RPS14, MRPS11, MRPS9
MRPS16GFM1No-18IMP3, RPS11, RPS16, RPS15A, RPS23, RPSA, MRPS7, MRPS2, RPS5, MRPS12, MRPS10, MRPS9, MRPS5, RPSAP58, RPS20, RPS14, MRPS11, RPS2
MRPS16TUFMNo-3MRPS2, RPSA, RPSAP58
ELAC2TSFMNo-1UBC
ELAC2ATP5A1No-1UBC
ELAC2VARS2No-1UBC
ELAC2MTO1No-1UBC
ELAC2TARS2No-1UBC
ELAC2MRPL3No-1UBC
ELAC2GFM1No-1UBC
ELAC2MRPS22No-1UBC
ELAC2AIFM1No-3UBC, EXOG, ENDOG
ELAC2TUFMNo-1UBC
TSFMATP5A1No-1UBC
TSFMVARS2No-1UBC
TSFMMTO1No-1UBC
TSFMTARS2No-1UBC
TSFMMRPL3No-1UBC
TSFMGFM1No-2UBC, TUFM
TSFMMRPS22No-1UBC
TSFMAIFM1No-1UBC
TSFMTUFMYesbinding1UBC
ATP5A1VARS2No-1UBC
ATP5A1MTO1No-1UBC
ATP5A1TARS2No-1UBC
ATP5A1MRPL3No-1UBC
ATP5A1GFM1No-1UBC
ATP5A1MRPS22No-1UBC
ATP5A1AIFM1No-1UBC
ATP5A1TUFMNo-1UBC
MARS2NARS2Yesbinding3EPRS, IARS2, IARS
VARS2MTO1No-1UBC
VARS2TARS2No-1UBC
VARS2MRPL3No-1UBC
VARS2GFM1No-1UBC
VARS2MRPS22No-1UBC
VARS2AIFM1No-1UBC
VARS2TUFMNo-1UBC
MTO1TARS2No-1UBC
MTO1MRPL3No-1UBC
MTO1GTPBP3Yesbinding0
MTO1GFM1No-1UBC
MTO1MRPS22No-1UBC
MTO1AIFM1No-1UBC
MTO1TUFMNo-1UBC
TARS2MRPL3No-1UBC
TARS2GFM1No-1UBC
TARS2MRPS22No-1UBC
TARS2AIFM1No-1UBC
TARS2TUFMNo-1UBC
MRPL3GFM1Yesbinding40MRPL13, RPS11, MRPS11, RPS3, MRPL2, MRPL15, MRPL22, RPL10A, RPL5, RPS15A, MRPL1, MRPL4, RPL13A, RPL8, MRPL24, RPL26, RPL9, RPL35, RPS14, RPS15, MRPS9, RPL10L, RPS16, RPL26L1, RPL4, RPL23A, MRPS7, MRPL11, RPL11, MRPL16, RPL12, RPL17, RPL27A, RPS5, RPL7, MRPS5, UBC, RPL7L1, RPL23, RPS2
MRPL3MRPS22No-1UBC
MRPL3AIFM1No-1UBC
MRPL3TUFMNo-6GFM1, GFM2, UBC, EFTUD1, EEF2, EFTUD2
GFM1MRPS22No-1UBC
GFM1AIFM1No-1UBC
GFM1TUFMYesbinding4MRPS2, UBC, RPSA, RPSAP58
MRPS22AIFM1No-1UBC
MRPS22TUFMNo-1UBC
AIFM1TUFMNo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MRPS16MRPL3Yes55S ribosome, mitochondrial75MRPL28, MRPL20, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL23, MRPL36, DAP3, MRPL15, MRPL30, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS14, MRPS11, MRPL34, MRPS15, MRPL2, MRPL51, MRPS6, MRPL54, MRPL52, MRPS22, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPS5, MRPL44, MRPL49, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPS24, MRPL43, MRPL17, MRPS34, MRPL18, MRPL33, MRPL41, MRPL11, MRPS12, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL27, MRPL53, MRPL40, MRPS17, MRPL38, MRPL21, MRPL19, MRPL12, MRPL14, MRPS35, MRPS9
MRPS16MRPS22Yes28S ribosomal subunit, mitochondrial;55S ribosome, mitochondrial75MRPL28, MRPL20, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL23, MRPL36, MRPL2, MRPL15, MRPL30, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS14, MRPS11, MRPL34, MRPS15, DAP3, MRPL51, MRPS6, MRPL54, MRPL52, MRPL3, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPS5, MRPL44, MRPL49, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPS24, MRPL43, MRPL17, MRPS34, MRPL18, MRPL33, MRPL41, MRPL11, MRPS12, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL27, MRPL53, MRPL40, MRPS17, MRPL38, MRPL21, MRPL19, MRPL12, MRPL14, MRPS35, MRPS9
MRPS16MRPL44Yes55S ribosome, mitochondrial75MRPL28, MRPL20, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL23, MRPL36, DAP3, MRPL15, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS14, MRPS22, MRPS11, MRPL34, MRPS15, MRPL2, MRPL51, MRPS6, MRPL30, MRPL52, MRPL3, MRPL54, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPS5, MRPL49, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPS24, MRPL43, MRPL17, MRPS34, MRPL18, MRPL33, MRPL41, MRPL11, MRPS12, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL27, MRPL53, MRPL40, MRPS17, MRPL38, MRPS9, MRPL19, MRPL12, MRPL14, MRPS35, MRPL21
MRPL3MRPS22Yes55S ribosome, mitochondrial75MRPL28, MRPL20, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL23, MRPS12, MRPL36, MRPL2, MRPL15, MRPL30, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS16, MRPS11, MRPL34, MRPS15, DAP3, MRPL51, MRPS6, MRPL54, MRPL52, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPL19, MRPL44, MRPL49, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPS24, MRPL43, MRPL17, MRPS34, MRPL18, MRPL33, MRPL41, MRPL11, MRPS14, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL27, MRPL53, MRPL40, MRPS17, MRPL38, MRPL21, MRPS5, MRPL12, MRPL14, MRPS35, MRPS9
MRPL3MRPL44Yes55S ribosome, mitochondrial;39S ribosomal subunit, mitochondrial75MRPL28, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL38, MRPS12, MRPL36, DAP3, MRPL15, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS16, MRPS22, MRPS11, MRPL49, MRPL34, MRPS15, MRPL2, MRPL51, MRPS6, MRPL30, MRPL52, MRPL54, MRPS34, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPL19, MRPS24, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPL27, MRPL43, MRPL17, MRPL20, MRPL18, MRPL33, MRPL41, MRPL11, MRPS14, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL23, MRPL53, MRPL40, MRPS17, MRPS9, MRPS5, MRPL12, MRPL14, MRPS35, MRPL21
MRPS22MRPL44Yes55S ribosome, mitochondrial75MRPL28, MRPL13, MRPL55, MRPL46, MRPL1, MRPS36, MRPS33, MRPS2, MRPL38, MRPS12, MRPL36, DAP3, MRPL15, MRPS28, MRPL47, MRPS23, MRPL22, MRPS25, MRPS18A, MRPL37, MRPL45, MRPL4, MRPS26, MRPS16, MRPS11, MRPL49, MRPL34, MRPS15, MRPL2, MRPL51, MRPS6, MRPL30, MRPL52, MRPL3, MRPL54, MRPS34, MRPS30, MRPL48, MRPS31, MRPL39, MRPL16, MRPL32, LACTB, MRPL19, MRPS24, MRPL10, MRPL50, MRPS18C, MRPS18B, MRPS7, MRPL24, MRPL27, MRPL43, MRPL17, MRPL20, MRPL18, MRPL33, MRPL41, MRPL11, MRPS14, MRPS10, MRPS27, MRPS21, MRPL35, MRPL9, MRPL23, MRPL53, MRPL40, MRPS17, MRPS9, MRPS5, MRPL12, MRPL14, MRPS35, MRPL21

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MRPS16MRPL3No1MRPS9
MRPS16MRPS22No2MRPS25, MRPS26
MRPS16MRPL44No2HNRNPU, MPV17
ATP5A1TXN2No1HSPA1L
ATP5A1TUFMNo2RPS15A, RPS3
TXN2MRPL3No1MRPL23
TXN2MRPL44No1ILF3
TXN2TUFMNo5RPS16, MRPL23, RPL8, RPL9; RPL9P7; RPL9P8; RPL9P9, RPL9
MRPL3MRPL44No6MRPL39, MRPL19, MRPL41, MRPL9, MRPL42, MRPL13
MRPL3TUFMNo3MRPL4, MRPL23, MRPL17
MRPL44TUFMNo1MRPL24

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
MRPS16MRPL3Yes4MRPL44, MRPL3, MRPS22, MRPS16
MRPS16MRPS22Yes4MRPL44, MRPL3, MRPS22, MRPS16
MRPS16MRPL44Yes4MRPL44, MRPL3, MRPS22, MRPS16
MRPL3MRPS22Yes4MRPL44, MRPL3, MRPS22, MRPS16
MRPL3MRPL44Yes4MRPL44, MRPL3, MRPS22, MRPS16
MRPS22MRPL44Yes4MRPL44, MRPL3, MRPS22, MRPS16

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Aminoacyl-tRNA biosynthesishsa009707.319MTFMT, MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
Metabolic pathwayshsa011002.492ATP5A1, EARS2
Ribosomehsa030105.692MRPL3, MRPS16

NET-GE enrichment

Term New enriched termICP valueGenes
Genetic Information ProcessingNEW2.480.0MTFMT, MARS2, AARS2, PNPT1, MRPS16, VARS2, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, TUFM, AIFM1, ELAC2, FARS2, CARS2, NARS2
Aminoacyl-tRNA biosynthesis (hsa00970) -7.310.0MTFMT, MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
TranslationNEW3.910.0MTFMT, MARS2, AARS2, MRPS16, NARS2, TARS2, PNPT1, GFM1, FARS2, EARS2, MRPL44, MRPL3, TUFM, ELAC2, VARS2, CARS2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Gene ExpressionR-HSA-741602.728MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
Organelle biogenesis and maintenanceR-HSA-18522414.638MTFMT, TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial translationR-HSA-53682876.498MTFMT, TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial tRNA aminoacylationR-HSA-3797268.598MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA AminoacylationR-HSA-3797247.598MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
Mitochondrial translation elongationR-HSA-53898406.597TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial translation initiationR-HSA-53682866.595MTFMT, MRPL44, MRPL3, MRPS22, MRPS16
Mitochondrial translation terminationR-HSA-54192766.594MRPL44, MRPL3, MRPS22, MRPS16
MetabolismR-HSA-14307282.342ATP5A1, LYRM4

NET-GE enrichment

Term New enriched termICP valueGenes
Mitochondrial tRNA aminoacylation (R-HSA-379726) -8.590.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA Aminoacylation (R-HSA-379724) -7.590.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
Organelle biogenesis and maintenance (R-HSA-1852241) -4.630.0MTFMT, TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial translation elongation (R-HSA-5389840) -6.590.0TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial translation termination (R-HSA-5419276) -6.590.004MRPL44, MRPL3, MRPS22, MRPS16
Mitochondrial translation (R-HSA-5368287) -6.490.0MTFMT, TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
Mitochondrial translation initiation (R-HSA-5368286) -6.590.0MTFMT, MRPL44, MRPL3, MRPS22, MRPS16
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1823NARS2, MRPL44, GFM1, AIFM1, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, ELAC2, CARS2, TUFM, ATP5A1, MTO1, PNPT1, FARS2
catalytic activity (GO:0003824) 1.0521MTFMT, MTO1, GTPBP3, TRMT5, TUFM, MRPL44, VARS2, C12orf65, TARS2, PNPT1, GFM1, EARS2, AARS2, TXN2, NARS2, AIFM1, ELAC2, FARS2, ATP5A1, CARS2, MARS2
organic cyclic compound binding (GO:0097159) 1.0520MARS2, AARS2, PNPT1, TSFM, VARS2, C12orf65, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
heterocyclic compound binding (GO:1901363) 1.0620MARS2, AARS2, PNPT1, TSFM, VARS2, C12orf65, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
nucleic acid binding (GO:0003676) 1.4416AARS2, TUFM, TSFM, NARS2, C12orf65, TARS2, PNPT1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, ELAC2, FARS2, ATP5A1
small molecule binding (GO:0036094) 1.8914MARS2, AARS2, TUFM, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, GFM1, AIFM1, GTPBP3, FARS2, CARS2
RNA binding (GO:0003723) 2.3614AARS2, PNPT1, TSFM, C12orf65, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, TUFM, ELAC2, FARS2
nucleoside phosphate binding (GO:1901265) 1.9614GTPBP3, AARS2, TUFM, VARS2, TARS2, EARS2, GFM1, ATP5A1, MTO1, NARS2, AIFM1, FARS2, CARS2, MARS2
nucleotide binding (GO:0000166) 1.9614MARS2, AARS2, TUFM, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, MTO1, AIFM1, GTPBP3, FARS2, CARS2
carbohydrate derivative binding (GO:0097367) 2.0312MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
purine ribonucleoside triphosphate binding (GO:0035639) 2.2212MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
purine nucleoside binding (GO:0001883) 2.2212MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
protein binding (GO:0005515) 0.4612GTPBP3, PNPT1, MRPS16, FARS2, RMND1, MRPL44, GFM1, ATP5A1, TUFM, AIFM1, VARS2, TXN2
ribonucleoside binding (GO:0032549) 2.2212MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
purine ribonucleotide binding (GO:0032555) 2.212MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
purine nucleotide binding (GO:0017076) 2.1912MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
purine ribonucleoside binding (GO:0032550) 2.2212MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
ribonucleotide binding (GO:0032553) 2.1912MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
nucleoside binding (GO:0001882) 2.2112MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
hydrolase activity (GO:0016787) 1.99GTPBP3, C12orf65, MRPL44, GFM1, PNPT1, TUFM, ATP5A1, ELAC2, VARS2
poly(A) RNA binding (GO:0044822) 2.699TUFM, TSFM, MRPL44, GFM1, PNPT1, MRPL3, MTO1, ATP5A1, ELAC2
adenyl ribonucleotide binding (GO:0032559) 2.419MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, EARS2, FARS2, CARS2
ATP binding (GO:0005524) 2.439MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, EARS2, FARS2, CARS2
adenyl nucleotide binding (GO:0030554) 2.49MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, EARS2, FARS2, CARS2
aminoacyl-tRNA ligase activity (GO:0004812) 5.938MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
ligase activity (GO:0016874) 3.728MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
ligase activity, forming carbon-oxygen bonds (GO:0016875) 5.938MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876) 5.938MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
hydrolase activity, acting on ester bonds (GO:0016788) 3.15ELAC2, PNPT1, VARS2, C12orf65, MRPL44
cation binding (GO:0043169) 1.44AARS2, FARS2, ELAC2, CARS2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.034ATP5A1, TUFM, GFM1, GTPBP3
structural molecule activity (GO:0005198) 3.14MRPL3, SLC25A26, MRPS16, MRPS22
nucleoside-triphosphatase activity (GO:0017111) 3.094ATP5A1, TUFM, GFM1, GTPBP3
translation factor activity, RNA binding (GO:0008135) 5.074TUFM, C12orf65, GFM1, TSFM
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.034TUFM, ATP5A1, GTPBP3, GFM1
ion binding (GO:0043167) 1.364AARS2, FARS2, ELAC2, CARS2
structural constituent of ribosome (GO:0003735) 4.324MRPL3, SLC25A26, MRPS16, MRPS22
pyrophosphatase activity (GO:0016462) 3.044ATP5A1, TUFM, GFM1, GTPBP3
metal ion binding (GO:0046872) 1.414AARS2, FARS2, ELAC2, CARS2
tRNA binding (GO:0000049) 5.953AARS2, FARS2, EARS2
guanyl ribonucleotide binding (GO:0032561) 3.733GTPBP3, TUFM, GFM1
nuclease activity (GO:0004518) 4.333PNPT1, ELAC2, MRPL44
transporter activity (GO:0005215) 2.573ATP5A1, SFXN4, SLC25A26
ribonuclease activity (GO:0004540) 5.043PNPT1, ELAC2, MRPL44
GTPase activity (GO:0003924) 4.313GTPBP3, TUFM, GFM1
transmembrane transporter activity (GO:0022857) 2.823ATP5A1, SFXN4, SLC25A26
guanyl nucleotide binding (GO:0019001) 3.733GTPBP3, TUFM, GFM1
transferase activity (GO:0016740) 1.953MTFMT, PNPT1, TRMT5
translation elongation factor activity (GO:0003746) 6.273TUFM, GFM1, TSFM
oxidoreductase activity (GO:0016491) 3.123AIFM1, MTO1, TXN2
GTP binding (GO:0005525) 3.783GTPBP3, TUFM, GFM1
substrate-specific transmembrane transporter activity (GO:0022891) 2.92ATP5A1, SFXN4
coenzyme binding (GO:0050662) 4.532AIFM1, MTO1
substrate-specific transporter activity (GO:0022892) 2.722ATP5A1, SFXN4
endonuclease activity (GO:0004519) 4.782ELAC2, MRPL44
carboxylic ester hydrolase activity (GO:0052689) 4.812C12orf65, VARS2
ion transmembrane transporter activity (GO:0015075) 3.042ATP5A1, SFXN4
transferase activity, transferring one-carbon groups (GO:0016741) 4.32MTFMT, TRMT5
macromolecular complex binding (GO:0044877) 2.612C12orf65, TXN2
cofactor binding (GO:0048037) 4.162AIFM1, MTO1
flavin adenine dinucleotide binding (GO:0050660) 5.412AIFM1, MTO1

NET-GE enrichment

Term New enriched termICP valueGenes
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.003MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
heterocyclic compound binding (GO:1901363) -1.060.009MARS2, AARS2, PNPT1, TSFM, VARS2, C12orf65, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
nucleoside phosphate binding (GO:1901265) -1.960.015MTO1, GTPBP3, AARS2, TUFM, TSFM, VARS2, TARS2, PNPT1, GFM1, MRPL44, EARS2, MRPL3, TXN2, NARS2, AIFM1, FARS2, ATP5A1, CARS2, MARS2
nucleoside binding (GO:0001882) -2.210.003MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
anion binding (GO:0043168) NEW4.170.003MARS2, AARS2, TUFM, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, GFM1, AIFM1, GTPBP3, FARS2, CARS2
tRNA binding (GO:0000049) -5.950.0EARS2, PNPT1, FARS2, AARS2, TUFM
nucleotide binding (GO:0000166) -1.960.015MARS2, AARS2, PNPT1, TSFM, NARS2, VARS2, TARS2, EARS2, MTO1, MRPL44, ATP5A1, MRPL3, TXN2, AIFM1, GTPBP3, TUFM, FARS2, GFM1, CARS2
transferase activity, transferring one-carbon groups (GO:0016741) -4.30.002MTFMT, GTPBP3, TRMT5, MRPS16, TUFM, EARS2, FARS2
purine nucleoside binding (GO:0001883) -2.220.003MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
ribonucleoside binding (GO:0032549) -2.220.003MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
purine nucleotide binding (GO:0017076) -2.190.004MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
poly(A) RNA binding (GO:0044822) -2.690.003MRPS16, TSFM, AIFM1, EARS2, GFM1, MRPL44, PNPT1, MRPL3, MTO1, ATP5A1, TUFM, ELAC2, FARS2
translation factor activity, nucleic acid binding (GO:0008135) -5.070.002AARS2, TSFM, C12orf65, TUFM, MRPL3, GFM1
small molecule binding (GO:0036094) -1.890.003MARS2, AARS2, TUFM, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, GFM1, AIFM1, GTPBP3, FARS2, CARS2
catalytic activity (GO:0003824) -1.050.025MTFMT, GTPBP3, TRMT5, TUFM, MRPL44, VARS2, TARS2, PNPT1, GFM1, EARS2, AARS2, TXN2, NARS2, AIFM1, ELAC2, FARS2, ATP5A1, CARS2, MARS2
aminoacyl-tRNA ligase activity (GO:0004812) -5.930.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
ligase activity (GO:0016874) -3.720.001MARS2, NARS2, VARS2, TARS2, AARS2, TUFM, EARS2, FARS2, CARS2
ligase activity, forming carbon-oxygen bonds (GO:0016875) -5.930.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876) -5.930.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
carbohydrate derivative binding (GO:0097367) -2.030.015MARS2, AARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2, NARS2
organic cyclic compound binding (GO:0097159) -1.050.011MARS2, AARS2, PNPT1, TSFM, VARS2, C12orf65, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
RNA binding (GO:0003723) -2.360.0GTPBP3, AARS2, MRPS16, TSFM, PNPT1, FARS2, C12orf65, NARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, MTO1, AIFM1, TUFM, ELAC2, VARS2
purine ribonucleotide binding (GO:0032555) -2.20.003MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
translation elongation factor activity (GO:0003746) -6.270.001TUFM, GFM1, TSFM
purine ribonucleoside binding (GO:0032550) -2.220.003MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
ribonucleotide binding (GO:0032553) -2.190.004MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, TUFM, GTPBP3, FARS2, CARS2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
metabolic process (GO:0008152) 0.5828NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
organic substance metabolic process (GO:0071704) 0.6327NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cellular process (GO:0009987) 0.2627NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cellular metabolic process (GO:0044237) 0.6927NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
primary metabolic process (GO:0044238) 0.6925NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, ELAC2, CARS2, TRMT5, TUFM, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cellular nitrogen compound metabolic process (GO:0034641) 1.2225NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, ELAC2, CARS2, TRMT5, TUFM, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
nitrogen compound metabolic process (GO:0006807) 1.1325NARS2, ATP5A1, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, ELAC2, CARS2, TRMT5, TUFM, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cellular macromolecule metabolic process (GO:0044260) 0.9325NARS2, MRPL44, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, CARS2, TRMT5, MRPS22, SLC25A26, MTO1, PNPT1, FARS2
macromolecule metabolic process (GO:0043170) 0.8325NARS2, MRPL44, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, CARS2, TRMT5, MRPS22, SLC25A26, MTO1, PNPT1, FARS2
cellular biosynthetic process (GO:0044249) 1.3720MTFMT, MARS2, AARS2, MRPS16, TSFM, RMND1, NARS2, C12orf65, VARS2, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, SLC25A26, MRPS22, TUFM, FARS2, CARS2
biosynthetic process (GO:0009058) 1.3220MTFMT, MARS2, AARS2, MRPS22, TSFM, RMND1, NARS2, C12orf65, VARS2, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, SLC25A26, MRPS16, TUFM, FARS2, CARS2
single-organism process (GO:0044699) 0.4820MARS2, LYRM4, MRPS22, MRPL44, FARS2, C12orf65, TARS2, PNPT1, MTO1, SLC25A26, EARS2, AARS2, MRPL3, CARS2, AIFM1, MRPS16, VARS2, ATP5A1, TXN2, NARS2
organic substance biosynthetic process (GO:1901576) 1.3420MTFMT, MARS2, AARS2, MRPS22, TSFM, RMND1, NARS2, C12orf65, TUFM, TARS2, ATP5A1, GFM1, MRPL44, EARS2, MRPL3, SLC25A26, MRPS16, FARS2, VARS2, CARS2
macromolecule biosynthetic process (GO:0009059) 1.6119MTFMT, MARS2, AARS2, MRPS22, TSFM, RMND1, FARS2, C12orf65, TARS2, MRPL44, GFM1, EARS2, MRPL3, SLC25A26, MRPS16, TUFM, VARS2, CARS2, NARS2
cellular macromolecule biosynthetic process (GO:0034645) 1.6619MTFMT, MARS2, AARS2, MRPS16, TSFM, RMND1, VARS2, C12orf65, TARS2, MRPL44, GFM1, EARS2, MRPL3, SLC25A26, MRPS22, TUFM, FARS2, CARS2, NARS2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.5918MTFMT, MARS2, AARS2, MRPS16, TSFM, RMND1, FARS2, C12orf65, TARS2, ATP5A1, GFM1, EARS2, MRPL3, SLC25A26, TUFM, VARS2, CARS2, NARS2
organonitrogen compound metabolic process (GO:1901564) 2.3218MTFMT, MARS2, AARS2, TSFM, MRPS16, RMND1, VARS2, C12orf65, TARS2, ATP5A1, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2, NARS2
organonitrogen compound biosynthetic process (GO:1901566) 2.8518MTFMT, MARS2, AARS2, MRPS16, TSFM, RMND1, FARS2, C12orf65, TARS2, ATP5A1, GFM1, EARS2, MRPL3, SLC25A26, TUFM, VARS2, CARS2, NARS2
cellular protein metabolic process (GO:0044267) 1.6317MTFMT, MARS2, MRPS16, TSFM, RMND1, NARS2, C12orf65, VARS2, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2
cellular amide metabolic process (GO:0043603) 3.2317MTFMT, MARS2, TSFM, MRPS16, RMND1, VARS2, C12orf65, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2, NARS2
nucleobase-containing compound metabolic process (GO:0006139) 1.3517MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
protein metabolic process (GO:0019538) 1.4517MTFMT, MARS2, TSFM, MRPS16, RMND1, NARS2, C12orf65, VARS2, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2
peptide biosynthetic process (GO:0043043) 3.7317MTFMT, MARS2, MRPS16, TSFM, RMND1, NARS2, C12orf65, VARS2, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2
cellular aromatic compound metabolic process (GO:0006725) 1.317MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
amide biosynthetic process (GO:0043604) 3.617MTFMT, MARS2, TSFM, MRPS16, RMND1, VARS2, C12orf65, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, FARS2, CARS2, NARS2
single-organism cellular process (GO:0044763) 0.6517MARS2, AARS2, MRPS16, MRPS22, PNPT1, NARS2, C12orf65, TARS2, ATP5A1, FARS2, EARS2, MRPL44, MRPL3, TXN2, AIFM1, VARS2, CARS2
peptide metabolic process (GO:0006518) 3.4417MTFMT, MARS2, MRPS16, TSFM, RMND1, FARS2, C12orf65, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, VARS2, CARS2, NARS2
translation (GO:0006412) 3.7917MTFMT, MARS2, MRPS16, TSFM, RMND1, FARS2, C12orf65, TARS2, AARS2, GFM1, EARS2, MRPL3, SLC25A26, TUFM, VARS2, CARS2, NARS2
organic cyclic compound metabolic process (GO:1901360) 1.2617MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
heterocycle metabolic process (GO:0046483) 1.3117MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
nucleic acid metabolic process (GO:0090304) 1.4616MTFMT, MARS2, TRMT5, MRPL44, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
RNA metabolic process (GO:0016070) 1.5915MTFMT, MARS2, TRMT5, MRPL44, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, GTPBP3, ELAC2, FARS2, CARS2
ncRNA metabolic process (GO:0034660) 3.4414MTFMT, MARS2, TRMT5, MRPL44, NARS2, VARS2, TARS2, GTPBP3, MTO1, EARS2, AARS2, ELAC2, FARS2, CARS2
tRNA metabolic process (GO:0006399) 4.5213MTFMT, MARS2, TRMT5, NARS2, VARS2, TARS2, GTPBP3, MTO1, EARS2, AARS2, ELAC2, FARS2, CARS2
single-organism metabolic process (GO:0044710) 1.6313MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, MTO1, LYRM4, EARS2, CARS2, AIFM1, FARS2, TXN2
small molecule metabolic process (GO:0044281) 2.3811MARS2, AARS2, NARS2, VARS2, TARS2, ATP5A1, LYRM4, EARS2, CARS2, FARS2, TXN2
cellular component organization (GO:0016043) 1.2410AARS2, TRMT5, MRPS16, MRPS22, C12orf65, MRPL44, PNPT1, MRPL3, ELAC2, AIFM1
cellular component organization or biogenesis (GO:0071840) 1.2210AARS2, TRMT5, MRPS16, MRPS22, C12orf65, MRPL44, PNPT1, MRPL3, ELAC2, AIFM1
biological regulation (GO:0065007) 0.399TSFM, AIFM1, C12orf65, RMND1, ATP5A1, PNPT1, SFXN4, VARS2, TXN2
RNA processing (GO:0006396) 3.019MTFMT, GTPBP3, TRMT5, MRPL44, MTO1, PNPT1, AARS2, ELAC2, FARS2
ncRNA processing (GO:0034470) 3.778MTFMT, GTPBP3, TRMT5, AARS2, MTO1, MRPL44, ELAC2, FARS2
protein complex subunit organization (GO:0071822) 2.68AARS2, MRPS16, MRPS22, C12orf65, PNPT1, MRPL44, MRPL3, AIFM1
organic acid metabolic process (GO:0006082) 3.018MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
macromolecular complex subunit organization (GO:0043933) 2.148AARS2, MRPS16, MRPS22, C12orf65, PNPT1, MRPL44, MRPL3, AIFM1
cellular amino acid metabolic process (GO:0006520) 4.228MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
carboxylic acid metabolic process (GO:0019752) 3.128MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
regulation of cellular process (GO:0050794) 0.58TSFM, VARS2, C12orf65, RMND1, ATP5A1, PNPT1, AIFM1, TXN2
amino acid activation (GO:0043038) 5.768MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA aminoacylation (GO:0043039) 5.768MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA aminoacylation for protein translation (GO:0006418) 5.828MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
oxoacid metabolic process (GO:0043436) 3.128MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
translational elongation (GO:0006414) 4.928TSFM, MRPS16, C12orf65, GFM1, MRPL44, MRPL3, TUFM, MRPS22
regulation of biological process (GO:0050789) 0.458TSFM, VARS2, C12orf65, RMND1, PNPT1, ATP5A1, AIFM1, TXN2
mitochondrial translational elongation (GO:0070125) 5.37TSFM, MRPS16, GFM1, MRPL44, MRPL3, TUFM, MRPS22
tRNA processing (GO:0008033) 4.967MTFMT, GTPBP3, TRMT5, AARS2, MTO1, ELAC2, FARS2
regulation of primary metabolic process (GO:0080090) 1.086TSFM, VARS2, C12orf65, RMND1, PNPT1, AIFM1
regulation of metabolic process (GO:0019222) 1.026TSFM, VARS2, C12orf65, RMND1, PNPT1, AIFM1
regulation of macromolecule metabolic process (GO:0060255) 1.086TSFM, VARS2, C12orf65, RMND1, PNPT1, AIFM1
regulation of cellular metabolic process (GO:0031323) 1.076TSFM, VARS2, C12orf65, RMND1, PNPT1, AIFM1
regulation of nitrogen compound metabolic process (GO:0051171) 1.366TSFM, VARS2, C12orf65, RMND1, PNPT1, AIFM1
mitochondrial RNA metabolic process (GO:0000959) 6.366AARS2, TRMT5, TARS2, EARS2, PNPT1, ELAC2
mitochondrial translational termination (GO:0070126) 5.295MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
organelle organization (GO:0006996) 2.025TRMT5, PNPT1, AIFM1, ELAC2, MRPS16
macromolecular complex disassembly (GO:0032984) 4.535MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
cellular component disassembly (GO:0022411) 3.525MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
translational termination (GO:0006415) 5.225MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
cellular protein complex disassembly (GO:0043624) 4.925MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
protein complex disassembly (GO:0043241) 4.585MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
regulation of biological quality (GO:0065008) 1.684AIFM1, VARS2, SFXN4, TXN2
regulation of cellular protein metabolic process (GO:0032268) 1.994RMND1, AIFM1, C12orf65, VARS2
regulation of protein metabolic process (GO:0051246) 1.934RMND1, AIFM1, C12orf65, VARS2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464RMND1, C12orf65, VARS2, TSFM
transport (GO:0006810) 1.514PNPT1, SFXN4, ATP5A1, SLC25A26
regulation of biosynthetic process (GO:0009889) 1.374RMND1, C12orf65, VARS2, TSFM
RNA modification (GO:0009451) 4.944MTFMT, AARS2, TRMT5, GTPBP3
macromolecule modification (GO:0043412) 1.734MTFMT, AARS2, TRMT5, GTPBP3
regulation of macromolecule biosynthetic process (GO:0010556) 1.434RMND1, C12orf65, VARS2, TSFM
regulation of cellular biosynthetic process (GO:0031326) 1.384RMND1, C12orf65, VARS2, TSFM
tRNA modification (GO:0006400) 5.594MTFMT, AARS2, TRMT5, GTPBP3
regulation of gene expression (GO:0010468) 1.374RMND1, C12orf65, VARS2, TSFM
establishment of localization (GO:0051234) 1.484ATP5A1, SFXN4, PNPT1, SLC25A26
localization (GO:0051179) 1.44PNPT1, ATP5A1, SLC25A26, SFXN4
mitochondrion organization (GO:0007005) 3.694PNPT1, TRMT5, ELAC2, MRPS16
cellular component assembly (GO:0022607) 2.143AARS2, AIFM1, PNPT1
positive regulation of metabolic process (GO:0009893) 1.743RMND1, PNPT1, AIFM1
positive regulation of cellular metabolic process (GO:0031325) 1.813RMND1, PNPT1, AIFM1
homeostatic process (GO:0042592) 2.613AIFM1, SFXN4, TXN2
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.123PNPT1, ELAC2, MRPL44
cellular response to chemical stimulus (GO:0070887) 2.573PNPT1, AIFM1, TXN2
cellular response to stimulus (GO:0051716) 1.973PNPT1, AIFM1, TXN2
positive regulation of macromolecule metabolic process (GO:0010604) 1.813RMND1, PNPT1, AIFM1
posttranscriptional regulation of gene expression (GO:0010608) 3.643RMND1, C12orf65, VARS2
response to oxidative stress (GO:0006979) 3.93PNPT1, AIFM1, TXN2
macromolecular complex assembly (GO:0065003) 2.553AARS2, AIFM1, PNPT1
mitochondrial RNA processing (GO:0000963) 7.163PNPT1, TRMT5, ELAC2
single-organism localization (GO:1902578) 2.093ATP5A1, PNPT1, SLC25A26
positive regulation of biological process (GO:0048518) 1.23RMND1, PNPT1, AIFM1
tRNA aminoacylation for mitochondrial protein translation (GO:0070127) 8.123AARS2, TARS2, EARS2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433PNPT1, AIFM1, TSFM
ion transport (GO:0006811) 2.663ATP5A1, SFXN4, SLC25A26
protein complex assembly (GO:0006461) 2.783PNPT1, AIFM1, AARS2
regulation of cellular amide metabolic process (GO:0034248) 3.883RMND1, C12orf65, VARS2
single-organism transport (GO:0044765) 2.183ATP5A1, PNPT1, SLC25A26
response to chemical (GO:0042221) 1.983PNPT1, AIFM1, TXN2
cellular response to oxidative stress (GO:0034599) 4.73PNPT1, AIFM1, TXN2
response to organic substance (GO:0010033) 2.23PNPT1, AIFM1, TXN2
oxidation-reduction process (GO:0055114) 2.913AIFM1, MTO1, TXN2
RNA phosphodiester bond hydrolysis (GO:0090501) 4.833PNPT1, ELAC2, MRPL44
transmembrane transport (GO:0055085) 2.723ATP5A1, SLC25A26, SFXN4
response to stimulus (GO:0050896) 1.223PNPT1, AIFM1, TXN2
response to stress (GO:0006950) 1.83PNPT1, AIFM1, TXN2
cellular response to stress (GO:0033554) 2.513PNPT1, AIFM1, TXN2
regulation of translation (GO:0006417) 3.963RMND1, C12orf65, VARS2
positive regulation of cellular process (GO:0048522) 1.33RMND1, PNPT1, AIFM1
cellular homeostasis (GO:0019725) 3.232AIFM1, TXN2
regulation of catabolic process (GO:0009894) 3.522PNPT1, AIFM1
regulation of cellular catabolic process (GO:0031329) 3.832PNPT1, AIFM1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492RMND1, AIFM1
response to extracellular stimulus (GO:0009991) 3.712AIFM1, TXN2
regulation of cellular component organization (GO:0051128) 2.012RMND1, AIFM1
cellular catabolic process (GO:0044248) 2.622PNPT1, AIFM1
cellular macromolecular complex assembly (GO:0034622) 3.182AARS2, AIFM1
response to organic cyclic compound (GO:0014070) 3.072AIFM1, TXN2
organic cyclic compound catabolic process (GO:1901361) 3.732PNPT1, AIFM1
response to endogenous stimulus (GO:0009719) 2.792AIFM1, TXN2
organic substance catabolic process (GO:1901575) 2.452PNPT1, AIFM1
cellular macromolecule catabolic process (GO:0044265) 3.192PNPT1, AIFM1
cellular developmental process (GO:0048869) 1.822PNPT1, AIFM1
positive regulation of protein metabolic process (GO:0051247) 2.432RMND1, AIFM1
cellular response to organic substance (GO:0071310) 2.782PNPT1, AIFM1
mitochondrial RNA 3'-end processing (GO:0000965) 8.342PNPT1, ELAC2
negative regulation of biological process (GO:0048519) 1.332ATP5A1, PNPT1
developmental process (GO:0032502) 1.362ATP5A1, PNPT1
mitochondrial respiratory chain complex assembly (GO:0033108) 5.312AARS2, AIFM1
cellular response to external stimulus (GO:0071496) 4.22AIFM1, TXN2
RNA 3'-end processing (GO:0031123) 5.152PNPT1, ELAC2
heterocycle catabolic process (GO:0046700) 3.822PNPT1, AIFM1
single-organism developmental process (GO:0044767) 1.492ATP5A1, PNPT1
ion transmembrane transport (GO:0034220) 3.082ATP5A1, SFXN4
response to oxygen-containing compound (GO:1901700) 2.572AIFM1, TXN2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292PNPT1, RMND1
mitochondrial transport (GO:0006839) 5.022PNPT1, ATP5A1
nucleobase-containing compound catabolic process (GO:0034655) 3.92PNPT1, AIFM1
cell redox homeostasis (GO:0045454) 5.522AIFM1, TXN2
response to reactive oxygen species (GO:0000302) 4.52AIFM1, TXN2
cellular protein complex assembly (GO:0043623) 3.92AARS2, AIFM1
macromolecule catabolic process (GO:0009057) 3.02PNPT1, AIFM1
response to oxygen levels (GO:0070482) 4.022AIFM1, TXN2
RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) 5.412ELAC2, MRPL44
response to abiotic stimulus (GO:0009628) 2.82AIFM1, TXN2
cellular response to extracellular stimulus (GO:0031668) 4.572AIFM1, TXN2
cellular response to nutrient levels (GO:0031669) 4.72AIFM1, TXN2
cellular nitrogen compound catabolic process (GO:0044270) 3.82PNPT1, AIFM1
response to external stimulus (GO:0009605) 2.552AIFM1, TXN2
response to decreased oxygen levels (GO:0036293) 4.092AIFM1, TXN2
regulation of RNA metabolic process (GO:0051252) 1.522PNPT1, TSFM
response to nutrient levels (GO:0031667) 3.772AIFM1, TXN2
cell communication (GO:0007154) 3.042AIFM1, TXN2
response to hormone (GO:0009725) 3.332AIFM1, TXN2
aromatic compound catabolic process (GO:0019439) 3.792PNPT1, AIFM1
catabolic process (GO:0009056) 2.382PNPT1, AIFM1
negative regulation of cellular process (GO:0048523) 1.412PNPT1, ATP5A1

NET-GE enrichment

Term New enriched termICP valueGenes
carboxylic acid metabolic process (GO:0019752) -3.120.026MARS2, AARS2, NARS2, VARS2, TARS2, PNPT1, TUFM, EARS2, MRPL3, AIFM1, FARS2, ATP5A1, CARS2
RNA modification (GO:0009451) -4.940.011MTFMT, GTPBP3, TRMT5, MRPS16, MTO1
nucleic acid metabolic process (GO:0090304) -1.460.029MTFMT, MARS2, TRMT5, MRPL44, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, AIFM1, GTPBP3, ELAC2, FARS2, CARS2
cellular nitrogen compound metabolic process (GO:0034641) -1.220.014MTFMT, MARS2, TRMT5, PNPT1, MRPL44, VARS2, TARS2, ATP5A1, GFM1, EARS2, AARS2, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
nitrogen compound metabolic process (GO:0006807) -1.130.05MTFMT, MARS2, TRMT5, TUFM, MRPL44, NARS2, VARS2, TARS2, PNPT1, GFM1, EARS2, AARS2, MTO1, AIFM1, GTPBP3, ELAC2, FARS2, ATP5A1, CARS2
small molecule metabolic process (GO:0044281) -2.380.002MTO1, GTPBP3, AARS2, TUFM, LYRM4, VARS2, TARS2, ATP5A1, GFM1, EARS2, TXN2, NARS2, FARS2, CARS2, MARS2
ncRNA metabolic process (GO:0034660) -3.440.0MTFMT, MARS2, TRMT5, MRPS16, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, TUFM, GTPBP3, ELAC2, FARS2, CARS2
organic cyclic compound metabolic process (GO:1901360) -1.260.016MTFMT, GTPBP3, TRMT5, PNPT1, MRPL44, VARS2, TARS2, ATP5A1, GFM1, EARS2, AARS2, MTO1, NARS2, AIFM1, TUFM, ELAC2, FARS2, CARS2, MARS2
ncRNA processing (GO:0034470) -3.770.001MTFMT, GTPBP3, TRMT5, MRPS16, MTO1, PNPT1, TUFM, ELAC2, FARS2
nucleobase-containing compound metabolic process (GO:0006139) -1.350.004MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, AARS2, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2
single-organism metabolic process (GO:0044710) -1.630.026MTO1, GTPBP3, AARS2, PNPT1, LYRM4, VARS2, TARS2, ATP5A1, GFM1, EARS2, CARS2, NARS2, AIFM1, TUFM, ELAC2, FARS2, TXN2, MARS2
cellular macromolecule metabolic process (GO:0044260) -0.930.005NARS2, MRPL44, GFM1, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, AARS2, TSFM, RMND1, GTPBP3, ELAC2, CARS2, TRMT5, TUFM, MTO1, PNPT1, FARS2
cellular amino acid metabolic process (GO:0006520) -4.220.0MARS2, NARS2, VARS2, TARS2, AARS2, TUFM, EARS2, FARS2, CARS2
mitochondrial RNA processing (GO:0000963) -7.160.0PNPT1, ELAC2, MTO1
gene expression (GO:0010467) NEW5.80.003MARS2, AARS2, PNPT1, NARS2, VARS2, TARS2, ATP5A1, TUFM, EARS2, MRPL3, FARS2, CARS2
mitochondrial RNA 3-end processing (GO:0000965) -8.340.024PNPT1, ELAC2
mitochondrion organization (GO:0007005) -3.690.008MRPS16, MRPL44, MTO1, PNPT1, TUFM, ELAC2, AIFM1
tRNA modification (GO:0006400) -5.590.0MTFMT, GTPBP3, TRMT5, MTO1
tRNA aminoacylation for mitochondrial protein translation (GO:0070127) -8.120.0AARS2, TARS2, EARS2
mitochondrial translational elongation (GO:0070125) -5.30.001MRPL44, GFM1
tRNA processing (GO:0008033) -4.960.0MTFMT, GTPBP3, TRMT5, MTO1, TUFM, ELAC2, FARS2
cellular aromatic compound metabolic process (GO:0006725) -1.30.008MTFMT, MARS2, TRMT5, PNPT1, MRPL44, VARS2, TARS2, ATP5A1, GFM1, EARS2, AARS2, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2, NARS2
heterocycle metabolic process (GO:0046483) -1.310.007MTFMT, MARS2, TRMT5, PNPT1, MRPL44, NARS2, VARS2, TARS2, ATP5A1, GFM1, EARS2, AARS2, MTO1, AIFM1, GTPBP3, TUFM, ELAC2, FARS2, CARS2
RNA metabolic process (GO:0016070) -1.590.02MTFMT, MARS2, TRMT5, MRPL44, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, GTPBP3, ELAC2, FARS2, CARS2
organonitrogen compound metabolic process (GO:1901564) -2.320.001MARS2, AARS2, TUFM, VARS2, TARS2, ATP5A1, GFM1, EARS2, MTO1, GTPBP3, FARS2, CARS2, NARS2
tRNA metabolic process (GO:0006399) -4.520.0MTFMT, MARS2, TRMT5, NARS2, VARS2, TARS2, PNPT1, MTO1, EARS2, AARS2, TUFM, GTPBP3, ELAC2, FARS2, CARS2
amino acid activation (GO:0043038) -5.760.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA aminoacylation (GO:0043039) -5.760.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
tRNA aminoacylation for protein translation (GO:0006418) -5.820.0MARS2, NARS2, VARS2, TARS2, AARS2, EARS2, FARS2, CARS2
translational elongation (GO:0006414) -4.920.014TUFM, MRPL44, GFM1, TSFM
mitochondrial RNA metabolic process (GO:0000959) -6.360.0AARS2, TARS2, EARS2, MTO1, PNPT1, ELAC2
RNA processing (GO:0006396) -3.010.004MTFMT, GTPBP3, TRMT5, MRPS16, MRPL44, MTO1, PNPT1, MRPL3, TUFM, ELAC2, FARS2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.629NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cell part (GO:0044464) 0.1129NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
cytoplasmic part (GO:0044444) 0.8229NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
mitochondrion (GO:0005739) 2.4229NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
intracellular organelle (GO:0043229) 0.5129NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
intracellular part (GO:0044424) 0.2829NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
membrane-bounded organelle (GO:0043227) 0.4729NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
organelle (GO:0043226) 0.429NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
intracellular organelle part (GO:0044446) 0.8123NARS2, MRPL44, TUFM, SFXN4, AIFM1, MARS2, MRPS16, TARS2, EARS2, MRPL3, TXN2, TSFM, C12orf65, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, ATP5A1, GFM1, PNPT1, FARS2
mitochondrial part (GO:0044429) 2.9223NARS2, MRPL44, TUFM, SFXN4, AIFM1, MARS2, MRPS16, TARS2, EARS2, MRPL3, TXN2, TSFM, C12orf65, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, ATP5A1, GFM1, PNPT1, FARS2
organelle part (GO:0044422) 0.7923NARS2, MRPL44, TUFM, SFXN4, AIFM1, MARS2, MRPS16, TARS2, EARS2, MRPL3, TXN2, TSFM, C12orf65, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, ATP5A1, GFM1, PNPT1, FARS2
intracellular organelle lumen (GO:0070013) 3.0515MARS2, TRMT5, PNPT1, TSFM, NARS2, TARS2, ATP5A1, GFM1, LYRM4, EARS2, CARS2, AIFM1, ELAC2, FARS2, TXN2
membrane-enclosed lumen (GO:0031974) 3.0515MARS2, TRMT5, TSFM, NARS2, TARS2, PNPT1, GFM1, LYRM4, EARS2, CARS2, AIFM1, ELAC2, FARS2, ATP5A1, TXN2
organelle lumen (GO:0043233) 3.0515MARS2, TRMT5, PNPT1, TSFM, NARS2, TARS2, ATP5A1, GFM1, LYRM4, EARS2, CARS2, AIFM1, ELAC2, FARS2, TXN2
mitochondrial matrix (GO:0005759) 4.0313MARS2, TRMT5, TSFM, NARS2, TARS2, ATP5A1, GFM1, LYRM4, EARS2, CARS2, ELAC2, FARS2, TXN2
cytoplasm (GO:0005737) 1.0110MARS2, TRMT5, MRPS16, NARS2, TARS2, PNPT1, EARS2, AARS2, AIFM1, FARS2
membrane (GO:0016020) 0.6810MRPS16, SLC25A26, MRPL44, TUFM, PNPT1, MRPL3, SFXN4, MRPS22, AIFM1, ATP5A1
mitochondrial inner membrane (GO:0005743) 3.658MRPS16, SLC25A26, MRPL44, ATP5A1, MRPL3, SFXN4, MRPS22, AIFM1
organelle inner membrane (GO:0019866) 3.568MRPS16, SLC25A26, MRPL44, ATP5A1, MRPL3, SFXN4, MRPS22, AIFM1
organelle membrane (GO:0031090) 1.978MRPS16, SLC25A26, MRPL44, ATP5A1, MRPL3, SFXN4, MRPS22, AIFM1
mitochondrial membrane (GO:0031966) 3.318MRPS16, SLC25A26, MRPL44, ATP5A1, MRPL3, SFXN4, MRPS22, AIFM1
nucleus (GO:0005634) 1.077GTPBP3, TRMT5, TSFM, AIFM1, MRPL44, ELAC2, LYRM4
non-membrane-bounded organelle (GO:0043228) 1.767MRPS16, MRPS22, TUFM, MRPL44, MRPL3, ELAC2, TXN2
macromolecular complex (GO:0032991) 1.357MRPS16, MRPS22, PNPT1, C12orf65, ATP5A1, MRPL44, MRPL3
intracellular non-membrane-bounded organelle (GO:0043232) 1.767MRPS16, MRPS22, TUFM, MRPL44, MRPL3, ELAC2, TXN2
intracellular (GO:0005622) 2.376GTPBP3, MRPS16, TSFM, TUFM, MRPL3, GFM1
cytosol (GO:0005829) 1.685AIFM1, AARS2, VARS2, MARS2, CARS2
ribonucleoprotein complex (GO:1990904) 3.195MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
intracellular ribonucleoprotein complex (GO:0030529) 3.195MRPL44, C12orf65, MRPL3, MRPS22, MRPS16
membrane part (GO:0044425) 0.954ATP5A1, AIFM1, SFXN4, SLC25A26
ribosome (GO:0005840) 4.384MRPL44, MRPL3, MRPS22, MRPS16
ribosomal subunit (GO:0044391) 4.674C12orf65, MRPL3, MRPS22, MRPS16
integral component of membrane (GO:0016021) 1.143AIFM1, SLC25A26, SFXN4
nuclear part (GO:0044428) 1.553ATP5A1, ELAC2, TXN2
intrinsic component of membrane (GO:0031224) 1.133AIFM1, SLC25A26, SFXN4
protein complex (GO:0043234) 1.512ATP5A1, PNPT1
extracellular vesicle (GO:1903561) 1.892ATP5A1, TUFM
large ribosomal subunit (GO:0015934) 5.192C12orf65, MRPL3
small ribosomal subunit (GO:0015935) 5.572MRPS22, MRPS16
mitochondrial protein complex (GO:0098798) 4.782PNPT1, ATP5A1
extracellular exosome (GO:0070062) 1.892ATP5A1, TUFM
organelle envelope lumen (GO:0031970) 5.412PNPT1, AIFM1
organellar large ribosomal subunit (GO:0000315) 6.372C12orf65, MRPL3
cell (GO:0005623) 5.222AIFM1, TXN2
membrane-bounded vesicle (GO:0031988) 1.712ATP5A1, TUFM
organellar small ribosomal subunit (GO:0000314) 6.582MRPS22, MRPS16
extracellular organelle (GO:0043230) 1.892ATP5A1, TUFM
mitochondrial large ribosomal subunit (GO:0005762) 6.372C12orf65, MRPL3
mitochondrial small ribosomal subunit (GO:0005763) 6.582MRPS22, MRPS16
mitochondrial intermembrane space (GO:0005758) 5.512PNPT1, AIFM1
mitochondrial nucleoid (GO:0042645) 6.022ELAC2, TUFM
nucleoid (GO:0009295) 5.972ELAC2, TUFM
extracellular region part (GO:0044421) 1.572ATP5A1, TUFM
vesicle (GO:0031982) 1.642ATP5A1, TUFM

NET-GE enrichment

Term New enriched termICP valueGenes
intracellular membrane-bounded organelle (GO:0043231) -0.60.0ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, GTPBP3, MRPS22, NARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, ELAC2, LYRM4, TRMT5, TUFM, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
ribosome (GO:0005840) -4.380.01TUFM, MRPL44, MRPL3, MRPS22, MRPS16
organelle lumen (GO:0043233) -3.050.0MARS2, TRMT5, NARS2, TARS2, ATP5A1, TUFM, LYRM4, EARS2, MRPL3, CARS2, AIFM1, FARS2, TXN2
organellar small ribosomal subunit (GO:0000314) -6.580.024MRPS22, MRPS16
cytoplasmic part (GO:0044444) -0.820.0NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
mitochondrion (GO:0005739) -2.420.0MRPL44, GFM1, AIFM1, MTFMT, GTPBP3, MRPS16, NARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, TUFM, ELAC2, MRPS22, SLC25A26, ATP5A1, MTO1, PNPT1, FARS2
ribosomal subunit (GO:0044391) -4.670.026MRPL3, MRPS22, GFM1, MRPS16
intracellular organelle lumen (GO:0070013) -3.050.0MARS2, TRMT5, NARS2, TARS2, ATP5A1, TUFM, LYRM4, EARS2, MRPL3, CARS2, FARS2, TXN2
intracellular organelle (GO:0043229) -0.510.001ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, GTPBP3, MRPS16, NARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, TUFM, ELAC2, LYRM4, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
membrane-enclosed lumen (GO:0031974) -3.050.0MARS2, TRMT5, PNPT1, NARS2, TARS2, ATP5A1, TUFM, LYRM4, EARS2, MRPL3, TXN2, AIFM1, FARS2, CARS2
mitochondrial small ribosomal subunit (GO:0005763) -6.580.024MRPS22, MRPS16
mitochondrial matrix (GO:0005759) -4.030.0MARS2, TRMT5, NARS2, TARS2, ATP5A1, TUFM, LYRM4, EARS2, CARS2, FARS2, TXN2
intracellular part (GO:0044424) -0.280.005NARS2, ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, MARS2, MRPS16, TARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, GTPBP3, TUFM, ELAC2, LYRM4, CARS2, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
membrane-bounded organelle (GO:0043227) -0.470.011ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, GTPBP3, MRPS22, NARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, ELAC2, LYRM4, TRMT5, TUFM, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
organelle (GO:0043226) -0.40.015ATP5A1, GFM1, SFXN4, AIFM1, MTFMT, GTPBP3, MRPS16, NARS2, EARS2, MRPL3, VARS2, TXN2, AARS2, TSFM, C12orf65, RMND1, TUFM, ELAC2, LYRM4, TRMT5, MRPS22, SLC25A26, MRPL44, MTO1, PNPT1, FARS2
mitochondrial part (GO:0044429) -2.920.0MARS2, TRMT5, MRPS16, MRPS22, NARS2, LYRM4, TARS2, PNPT1, TUFM, SLC25A26, EARS2, MRPL3, TXN2, SFXN4, AIFM1, FARS2, ATP5A1, CARS2