Disease table of SHORT QT SYNDROME OMIM ID: PS609620

Gene-disease associations table

GeneAssociated with SHORT QT SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
KCNJ2ClinVar, OMIM, HUMSAVARHGNC link17q24.34PS609620, PS608583, 115000, PS192500
KCNQ1ClinVar, OMIM, HUMSAVARHGNC link11p15.56115000, 272120, PS609620, PS608583, PS192500, 220400
KCNH2ClinVar, OMIM, HUMSAVARHGNC link7q36.16272120, 603829, PS609620, PS604772, 115000, PS192500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KCNH2YES1SP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
KCNQ1KCNH2No3HSPA4, NEDD4L, KCNE1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Gastric acid secretionhsa049716.482KCNJ2, KCNQ1
Cholinergic synapsehsa047255.882KCNJ2, KCNQ1

NET-GE enrichment

Term New enriched termICP valueGenes
Gastric acid secretion (hsa04971) -6.480.0KCNJ2, KCNQ1, KCNH2
Digestive systemNEW4.120.025KCNJ2, KCNH2, KCNQ1
Cholinergic synapse (hsa04725) -5.880.031KCNJ2, KCNQ1
Nervous systemNEW3.770.039KCNJ2, KCNQ1, KCNH2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Neuronal SystemR-HSA-1123164.823KCNJ2, KCNH2, KCNQ1
Potassium ChannelsR-HSA-12960716.353KCNJ2, KCNQ1, KCNH2
Voltage gated Potassium channelsR-HSA-12960727.562KCNH2, KCNQ1

NET-GE enrichment

Term New enriched termICP valueGenes
Neuronal System (R-HSA-112316) -4.820.003KCNJ2, KCNQ1, KCNH2
Voltage gated Potassium channels (R-HSA-1296072) -7.560.001KCNH2, KCNQ1
Integration of energy metabolism (R-HSA-163685) NEW6.240.028KCNH2, KCNQ1
Potassium Channels (R-HSA-1296071) -6.350.0KCNJ2, KCNQ1, KCNH2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
potassium channel activity (GO:0005267) 4.943KCNJ2, KCNH2, KCNQ1
cation channel activity (GO:0005261) 4.043KCNJ2, KCNQ1, KCNH2
binding (GO:0005488) 0.183KCNJ2, KCNH2, KCNQ1
substrate-specific channel activity (GO:0022838) 3.673KCNJ2, KCNQ1, KCNH2
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) 7.793KCNJ2, KCNQ1, KCNH2
transmembrane transporter activity (GO:0022857) 2.823KCNJ2, KCNQ1, KCNH2
voltage-gated cation channel activity (GO:0022843) 4.833KCNJ2, KCNH2, KCNQ1
passive transmembrane transporter activity (GO:0022803) 3.63KCNJ2, KCNQ1, KCNH2
metal ion transmembrane transporter activity (GO:0046873) 3.713KCNJ2, KCNH2, KCNQ1
protein binding (GO:0005515) 0.463KCNJ2, KCNQ1, KCNH2
transporter activity (GO:0005215) 2.573KCNJ2, KCNH2, KCNQ1
ion channel activity (GO:0005216) 3.713KCNJ2, KCNH2, KCNQ1
cation transmembrane transporter activity (GO:0008324) 3.323KCNJ2, KCNH2, KCNQ1
substrate-specific transmembrane transporter activity (GO:0022891) 2.93KCNJ2, KCNH2, KCNQ1
inorganic cation transmembrane transporter activity (GO:0022890) 3.493KCNJ2, KCNQ1, KCNH2
substrate-specific transporter activity (GO:0022892) 2.723KCNJ2, KCNH2, KCNQ1
ion transmembrane transporter activity (GO:0015075) 3.043KCNJ2, KCNH2, KCNQ1
voltage-gated channel activity (GO:0022832) 4.493KCNJ2, KCNH2, KCNQ1
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.873KCNJ2, KCNQ1, KCNH2
channel activity (GO:0015267) 3.63KCNJ2, KCNH2, KCNQ1
gated channel activity (GO:0022836) 3.963KCNJ2, KCNH2, KCNQ1
voltage-gated potassium channel activity (GO:0005249) 5.243KCNJ2, KCNQ1, KCNH2
voltage-gated ion channel activity (GO:0005244) 4.493KCNJ2, KCNH2, KCNQ1
potassium ion transmembrane transporter activity (GO:0015079) 4.773KCNJ2, KCNH2, KCNQ1
ligand-gated channel activity (GO:0022834) 4.82KCNJ2, KCNH2
phosphatidylinositol binding (GO:0035091) 4.472KCNJ2, KCNQ1
phospholipid binding (GO:0005543) 3.912KCNJ2, KCNQ1
transmembrane receptor activity (GO:0099600) 2.532KCNJ2, KCNH2
ligand-gated ion channel activity (GO:0015276) 4.82KCNJ2, KCNH2
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546) 5.812KCNJ2, KCNQ1
lipid binding (GO:0008289) 3.262KCNJ2, KCNQ1
phosphatidylinositol bisphosphate binding (GO:1902936) 5.792KCNJ2, KCNQ1
molecular transducer activity (GO:0060089) 2.322KCNJ2, KCNH2
scaffold protein binding (GO:0097110) 5.932KCNH2, KCNQ1
enzyme binding (GO:0019899) 2.272KCNH2, KCNQ1
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) 8.352KCNH2, KCNQ1
phosphatidylinositol phosphate binding (GO:1901981) 5.052KCNJ2, KCNQ1
delayed rectifier potassium channel activity (GO:0005251) 6.152KCNQ1, KCNH2
inward rectifier potassium channel activity (GO:0005242) 6.652KCNJ2, KCNH2
identical protein binding (GO:0042802) 2.632KCNJ2, KCNH2
receptor activity (GO:0004872) 2.322KCNJ2, KCNH2

NET-GE enrichment

Term New enriched termICP valueGenes
potassium channel activity (GO:0005267) -4.940.0KCNJ2, KCNH2, KCNQ1
cation channel activity (GO:0005261) -4.040.0KCNJ2, KCNQ1, KCNH2
ion channel binding (GO:0044325) NEW5.020.024KCNH2, KCNQ1
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) -7.790.0KCNJ2, KCNQ1, KCNH2
ligand-gated ion channel activity (GO:0015276) -4.80.015KCNJ2, KCNH2
transmembrane transporter activity (GO:0022857) -2.820.013KCNJ2, KCNQ1, KCNH2
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) -8.350.0KCNH2, KCNQ1
delayed rectifier potassium channel activity (GO:0005251) -6.150.001KCNQ1, KCNH2
metal ion transmembrane transporter activity (GO:0046873) -3.710.001KCNJ2, KCNH2, KCNQ1
ion channel activity (GO:0005216) -3.710.001KCNJ2, KCNH2, KCNQ1
identical protein binding (GO:0042802) -2.630.014KCNJ2, KCNQ1, KCNH2
voltage-gated cation channel activity (GO:0022843) -4.830.0KCNJ2, KCNH2, KCNQ1
transporter activity (GO:0005215) -2.570.028KCNJ2, KCNH2, KCNQ1
potassium channel regulator activity (GO:0015459) NEW5.930.006KCNQ1, KCNH2
cation transmembrane transporter activity (GO:0008324) -3.320.037KCNJ2, KCNH2, KCNQ1
passive transmembrane transporter activity (GO:0022803) -3.60.001KCNJ2, KCNQ1, KCNH2
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.009KCNJ2, KCNQ1, KCNH2
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.002KCNJ2, KCNQ1, KCNH2
substrate-specific transporter activity (GO:0022892) -2.720.014KCNJ2, KCNH2, KCNQ1
voltage-gated ion channel activity (GO:0005244) -4.490.0KCNJ2, KCNH2, KCNQ1
ion transmembrane transporter activity (GO:0015075) -3.040.008KCNJ2, KCNQ1, KCNH2
voltage-gated channel activity (GO:0022832) -4.490.0KCNJ2, KCNH2, KCNQ1
monovalent inorganic cation transmembrane transporter activity (GO:0015077) -3.870.001KCNJ2, KCNQ1, KCNH2
channel activity (GO:0015267) -3.60.001KCNJ2, KCNH2, KCNQ1
gated channel activity (GO:0022836) -3.960.005KCNJ2, KCNH2, KCNQ1
voltage-gated potassium channel activity (GO:0005249) -5.240.0KCNJ2, KCNQ1, KCNH2
ligand-gated channel activity (GO:0022834) -4.80.015KCNJ2, KCNH2
substrate-specific channel activity (GO:0022838) -3.670.011KCNJ2, KCNQ1, KCNH2
potassium ion transmembrane transporter activity (GO:0015079) -4.770.0KCNJ2, KCNH2, KCNQ1
inward rectifier potassium channel activity (GO:0005242) -6.650.0KCNJ2, KCNH2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of membrane potential (GO:0042391) 3.893KCNJ2, KCNH2, KCNQ1
multicellular organismal signaling (GO:0035637) 5.363KCNJ2, KCNQ1, KCNH2
regulation of transport (GO:0051049) 2.243KCNJ2, KCNH2, KCNQ1
regulation of membrane repolarization (GO:0060306) 6.43KCNJ2, KCNQ1, KCNH2
action potential (GO:0001508) 5.423KCNJ2, KCNQ1, KCNH2
muscle system process (GO:0003012) 4.183KCNJ2, KCNQ1, KCNH2
multicellular organismal process (GO:0032501) 1.453KCNJ2, KCNQ1, KCNH2
signaling (GO:0023052) 3.253KCNJ2, KCNQ1, KCNH2
positive regulation of transmembrane transport (GO:0034764) 4.993KCNJ2, KCNQ1, KCNH2
regulation of ion transmembrane transport (GO:0034765) 3.773KCNJ2, KCNH2, KCNQ1
positive regulation of ion transmembrane transport (GO:0034767) 5.053KCNJ2, KCNQ1, KCNH2
regulation of biological process (GO:0050789) 0.453KCNJ2, KCNH2, KCNQ1
regulation of transmembrane transport (GO:0034762) 3.743KCNJ2, KCNH2, KCNQ1
positive regulation of potassium ion transport (GO:0043268) 6.093KCNJ2, KCNQ1, KCNH2
cellular response to stimulus (GO:0051716) 1.973KCNJ2, KCNQ1, KCNH2
regulation of localization (GO:0032879) 1.943KCNJ2, KCNQ1, KCNH2
cardiac muscle cell action potential (GO:0086001) 6.333KCNJ2, KCNQ1, KCNH2
cardiac muscle cell action potential involved in contraction (GO:0086002) 6.473KCNJ2, KCNH2, KCNQ1
potassium ion transmembrane transport (GO:0071805) 4.793KCNJ2, KCNQ1, KCNH2
membrane repolarization (GO:0086009) 7.023KCNJ2, KCNH2, KCNQ1
localization (GO:0051179) 1.43KCNJ2, KCNH2, KCNQ1
regulation of heart rate (GO:0002027) 5.293KCNJ2, KCNQ1, KCNH2
biological regulation (GO:0065007) 0.393KCNJ2, KCNQ1, KCNH2
inorganic cation transmembrane transport (GO:0098662) 3.553KCNJ2, KCNH2, KCNQ1
inorganic ion transmembrane transport (GO:0098660) 3.383KCNJ2, KCNH2, KCNQ1
positive regulation of biological process (GO:0048518) 1.23KCNJ2, KCNQ1, KCNH2
regulation of biological quality (GO:0065008) 1.683KCNJ2, KCNQ1, KCNH2
monovalent inorganic cation transport (GO:0015672) 3.743KCNJ2, KCNQ1, KCNH2
regulation of heart rate by cardiac conduction (GO:0086091) 6.333KCNJ2, KCNH2, KCNQ1
positive regulation of ion transport (GO:0043270) 4.363KCNJ2, KCNQ1, KCNH2
metal ion transport (GO:0030001) 3.363KCNJ2, KCNH2, KCNQ1
transport (GO:0006810) 1.513KCNJ2, KCNQ1, KCNH2
cardiac conduction (GO:0061337) 5.543KCNJ2, KCNH2, KCNQ1
positive regulation of transport (GO:0051050) 2.93KCNJ2, KCNQ1, KCNH2
potassium ion transport (GO:0006813) 4.683KCNJ2, KCNH2, KCNQ1
cation transport (GO:0006812) 3.113KCNJ2, KCNH2, KCNQ1
ion transport (GO:0006811) 2.663KCNJ2, KCNQ1, KCNH2
regulation of heart contraction (GO:0008016) 4.353KCNJ2, KCNQ1, KCNH2
regulation of cellular process (GO:0050794) 0.53KCNJ2, KCNQ1, KCNH2
regulation of metal ion transport (GO:0010959) 3.943KCNJ2, KCNQ1, KCNH2
ion transmembrane transport (GO:0034220) 3.083KCNJ2, KCNH2, KCNQ1
single-organism transport (GO:0044765) 2.183KCNJ2, KCNQ1, KCNH2
regulation of system process (GO:0044057) 3.533KCNJ2, KCNQ1, KCNH2
regulation of potassium ion transmembrane transport (GO:1901379) 5.623KCNJ2, KCNQ1, KCNH2
regulation of multicellular organismal process (GO:0051239) 1.873KCNJ2, KCNQ1, KCNH2
membrane repolarization during cardiac muscle cell action potential (GO:0086013) 7.433KCNJ2, KCNQ1, KCNH2
membrane repolarization during action potential (GO:0086011) 7.433KCNJ2, KCNH2, KCNQ1
establishment of localization (GO:0051234) 1.483KCNJ2, KCNQ1, KCNH2
transmembrane transport (GO:0055085) 2.723KCNJ2, KCNH2, KCNQ1
single-organism localization (GO:1902578) 2.093KCNJ2, KCNQ1, KCNH2
system process (GO:0003008) 2.33KCNJ2, KCNH2, KCNQ1
single organism signaling (GO:0044700) 3.253KCNJ2, KCNH2, KCNQ1
single-organism process (GO:0044699) 0.483KCNJ2, KCNQ1, KCNH2
cellular potassium ion transport (GO:0071804) 4.793KCNJ2, KCNH2, KCNQ1
single-multicellular organism process (GO:0044707) 1.783KCNJ2, KCNH2, KCNQ1
regulation of potassium ion transport (GO:0043266) 5.313KCNJ2, KCNH2, KCNQ1
positive regulation of cation transmembrane transport (GO:1904064) 5.173KCNJ2, KCNH2, KCNQ1
regulation of cation transmembrane transport (GO:1904062) 4.43KCNJ2, KCNQ1, KCNH2
positive regulation of potassium ion transmembrane transport (GO:1901381) 6.433KCNJ2, KCNH2, KCNQ1
single-organism cellular process (GO:0044763) 0.653KCNJ2, KCNQ1, KCNH2
cardiac muscle cell membrane repolarization (GO:0099622) 7.433KCNJ2, KCNH2, KCNQ1
regulation of ion transport (GO:0043269) 3.43KCNJ2, KCNQ1, KCNH2
regulation of blood circulation (GO:1903522) 4.053KCNJ2, KCNQ1, KCNH2
cellular process (GO:0009987) 0.263KCNJ2, KCNH2, KCNQ1
cation transmembrane transport (GO:0098655) 3.433KCNJ2, KCNH2, KCNQ1
response to stimulus (GO:0050896) 1.223KCNJ2, KCNQ1, KCNH2
positive regulation of cellular process (GO:0048522) 1.33KCNJ2, KCNH2, KCNQ1
primary metabolic process (GO:0044238) 0.692KCNQ1, KCNH2
ion homeostasis (GO:0050801) 3.422KCNJ2, KCNH2
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) 6.842KCNH2, KCNQ1
striated muscle contraction (GO:0006941) 5.372KCNH2, KCNQ1
membrane depolarization (GO:0051899) 5.622KCNJ2, KCNH2
regulation of striated muscle contraction (GO:0006942) 5.382KCNJ2, KCNQ1
potassium ion homeostasis (GO:0055075) 6.842KCNJ2, KCNH2
cellular response to chemical stimulus (GO:0070887) 2.572KCNH2, KCNQ1
inorganic ion homeostasis (GO:0098771) 3.432KCNJ2, KCNH2
negative regulation of ion transmembrane transport (GO:0034766) 5.472KCNH2, KCNQ1
cardiac muscle contraction (GO:0060048) 5.882KCNH2, KCNQ1
negative regulation of transmembrane transport (GO:0034763) 5.382KCNQ1, KCNH2
ventricular cardiac muscle cell action potential (GO:0086005) 7.022KCNQ1, KCNH2
potassium ion export (GO:0071435) 7.432KCNQ1, KCNH2
muscle contraction (GO:0006936) 4.372KCNH2, KCNQ1
organic substance metabolic process (GO:0071704) 0.632KCNH2, KCNQ1
homeostatic process (GO:0042592) 2.612KCNJ2, KCNH2
regulation of cardiac muscle cell membrane repolarization (GO:0099623) 6.682KCNQ1, KCNH2
negative regulation of biological process (GO:0048519) 1.332KCNH2, KCNQ1
negative regulation of potassium ion transmembrane transport (GO:1901380) 6.682KCNQ1, KCNH2
negative regulation of transport (GO:0051051) 3.62KCNQ1, KCNH2
regulation of muscle contraction (GO:0006937) 4.752KCNJ2, KCNQ1
negative regulation of ion transport (GO:0043271) 4.942KCNH2, KCNQ1
negative regulation of potassium ion transport (GO:0043267) 6.262KCNQ1, KCNH2
regulation of muscle system process (GO:0090257) 4.512KCNJ2, KCNQ1
metabolic process (GO:0008152) 0.582KCNQ1, KCNH2
metal ion homeostasis (GO:0055065) 3.612KCNJ2, KCNH2
cation homeostasis (GO:0055080) 3.462KCNJ2, KCNH2
response to chemical (GO:0042221) 1.982KCNH2, KCNQ1
membrane depolarization during action potential (GO:0086010) 6.072KCNJ2, KCNH2
regulation of cardiac muscle contraction (GO:0055117) 5.572KCNJ2, KCNQ1
potassium ion export across plasma membrane (GO:0097623) 9.042KCNH2, KCNQ1
response to drug (GO:0042493) 3.712KCNH2, KCNQ1
negative regulation of cation transmembrane transport (GO:1904063) 5.652KCNQ1, KCNH2
cellular metabolic process (GO:0044237) 0.692KCNQ1, KCNH2
chemical homeostasis (GO:0048878) 2.972KCNJ2, KCNH2
membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915) 8.342KCNQ1, KCNH2
cellular response to drug (GO:0035690) 5.482KCNQ1, KCNH2
ventricular cardiac muscle cell membrane repolarization (GO:0099625) 8.342KCNQ1, KCNH2
negative regulation of cellular process (GO:0048523) 1.412KCNQ1, KCNH2
monovalent inorganic cation homeostasis (GO:0055067) 4.932KCNJ2, KCNH2

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.001KCNJ2, KCNH2, KCNQ1
multicellular organismal signaling (GO:0035637) -5.360.0KCNJ2, KCNH2, KCNQ1
single organism signaling (GO:0044700) -3.250.014KCNJ2, KCNH2, KCNQ1
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) -6.840.0KCNH2, KCNQ1
regulation of membrane repolarization (GO:0060306) -6.40.0KCNJ2, KCNH2, KCNQ1
positive regulation of transmembrane transport (GO:0034764) -4.990.0KCNJ2, KCNH2, KCNQ1
membrane repolarization during cardiac muscle cell action potential (GO:0086013) -7.430.0KCNJ2, KCNQ1, KCNH2
regulation of potassium ion transport (GO:0043266) -5.310.0KCNJ2, KCNQ1, KCNH2
muscle system process (GO:0003012) -4.180.0KCNJ2, KCNH2, KCNQ1
cellular response to drug (GO:0035690) -5.480.005KCNH2, KCNQ1
potassium ion homeostasis (GO:0055075) -6.840.0KCNJ2, KCNH2
potassium ion import (GO:0010107) NEW6.40.001KCNJ2, KCNH2
action potential (GO:0001508) -5.420.0KCNJ2, KCNH2, KCNQ1
regulation of ion transmembrane transport (GO:0034765) -3.770.022KCNJ2, KCNH2, KCNQ1
positive regulation of ion transmembrane transport (GO:0034767) -5.050.0KCNJ2, KCNH2, KCNQ1
cardiac muscle contraction (GO:0060048) -5.880.016KCNH2, KCNQ1
regulation of ion transport (GO:0043269) -3.40.005KCNJ2, KCNH2, KCNQ1
positive regulation of potassium ion transport (GO:0043268) -6.090.0KCNJ2, KCNQ1, KCNH2
ventricular cardiac muscle cell action potential (GO:0086005) -7.020.002KCNH2, KCNQ1
potassium ion export (GO:0071435) -7.430.0KCNQ1, KCNH2
cardiac muscle cell action potential (GO:0086001) -6.330.0KCNJ2, KCNQ1, KCNH2
regulation of system process (GO:0044057) -3.530.002KCNJ2, KCNQ1, KCNH2
potassium ion transmembrane transport (GO:0071805) -4.790.001KCNJ2, KCNQ1, KCNH2
membrane repolarization (GO:0086009) -7.020.0KCNJ2, KCNQ1, KCNH2
regulation of heart rate (GO:0002027) -5.290.0KCNJ2, KCNQ1, KCNH2
regulation of transmembrane transport (GO:0034762) -3.740.001KCNJ2, KCNH2, KCNQ1
inorganic ion transmembrane transport (GO:0098660) -3.380.006KCNJ2, KCNH2, KCNQ1
positive regulation of potassium ion transmembrane transport (GO:1901381) -6.430.0KCNJ2, KCNH2, KCNQ1
inorganic cation transmembrane transport (GO:0098662) -3.550.004KCNJ2, KCNH2, KCNQ1
cardiac conduction (GO:0061337) -5.540.0KCNJ2, KCNH2, KCNQ1
positive regulation of transport (GO:0051050) -2.90.009KCNJ2, KCNH2, KCNQ1
potassium ion transport (GO:0006813) -4.680.001KCNJ2, KCNH2, KCNQ1
cation transport (GO:0006812) -3.110.022KCNJ2, KCNH2, KCNQ1
regulation of heart contraction (GO:0008016) -4.350.003KCNJ2, KCNQ1, KCNH2
positive regulation of ion transport (GO:0043270) -4.360.0KCNJ2, KCNQ1, KCNH2
ion transmembrane transport (GO:0034220) -3.080.017KCNJ2, KCNQ1, KCNH2
cellular potassium ion transport (GO:0071804) -4.790.001KCNJ2, KCNQ1, KCNH2
metal ion transport (GO:0030001) -3.360.008KCNJ2, KCNQ1, KCNH2
monovalent inorganic cation homeostasis (GO:0055067) -4.930.013KCNJ2, KCNH2
signaling (GO:0023052) -3.250.014KCNJ2, KCNH2, KCNQ1
synaptic transmission (GO:0007268) NEW3.980.003KCNJ2, KCNH2, KCNQ1
cell-cell signaling (GO:0007267) NEW3.350.013KCNJ2, KCNQ1, KCNH2
cell communication (GO:0007154) NEW3.040.023KCNJ2, KCNQ1, KCNH2
membrane repolarization during action potential (GO:0086011) -7.430.0KCNJ2, KCNH2, KCNQ1
membrane depolarization during action potential (GO:0086010) -6.070.002KCNJ2, KCNH2
striated muscle contraction (GO:0006941) -5.370.009KCNH2, KCNQ1
regulation of metal ion transport (GO:0010959) -3.940.016KCNJ2, KCNH2, KCNQ1
cardiac muscle cell action potential involved in contraction (GO:0086002) -6.470.0KCNJ2, KCNH2, KCNQ1
cellular response to cAMP (GO:0071320) NEW5.820.031KCNH2, KCNQ1
membrane depolarization (GO:0051899) -5.620.021KCNJ2, KCNH2
regulation of potassium ion transmembrane transporter activity (GO:1901016) NEW6.020.005KCNH2, KCNQ1
monovalent inorganic cation transport (GO:0015672) -3.740.002KCNJ2, KCNQ1, KCNH2
regulation of heart rate by cardiac conduction (GO:0086091) -6.330.0KCNJ2, KCNH2, KCNQ1
regulation of delayed rectifier potassium channel activity (GO:1902259) NEW6.840.0KCNH2, KCNQ1
regulation of potassium ion transmembrane transport (GO:1901379) -5.620.0KCNJ2, KCNH2, KCNQ1
cation transmembrane transport (GO:0098655) -3.430.006KCNJ2, KCNH2, KCNQ1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.513KCNJ2, KCNH2, KCNQ1
transmembrane transporter complex (GO:1902495) 4.063KCNJ2, KCNH2, KCNQ1
cell part (GO:0044464) 0.113KCNJ2, KCNQ1, KCNH2
integral component of membrane (GO:0016021) 1.143KCNJ2, KCNH2, KCNQ1
membrane (GO:0016020) 0.683KCNJ2, KCNQ1, KCNH2
transporter complex (GO:1990351) 4.043KCNJ2, KCNQ1, KCNH2
voltage-gated potassium channel complex (GO:0008076) 5.343KCNJ2, KCNQ1, KCNH2
plasma membrane protein complex (GO:0098797) 3.553KCNJ2, KCNQ1, KCNH2
membrane protein complex (GO:0098796) 2.843KCNJ2, KCNQ1, KCNH2
cytoplasmic part (GO:0044444) 0.823KCNJ2, KCNH2, KCNQ1
potassium channel complex (GO:0034705) 5.323KCNJ2, KCNH2, KCNQ1
ion channel complex (GO:0034702) 4.183KCNJ2, KCNH2, KCNQ1
cation channel complex (GO:0034703) 4.693KCNJ2, KCNQ1, KCNH2
membrane part (GO:0044425) 0.953KCNJ2, KCNH2, KCNQ1
plasma membrane (GO:0005886) 1.393KCNJ2, KCNQ1, KCNH2
intracellular part (GO:0044424) 0.283KCNJ2, KCNH2, KCNQ1
macromolecular complex (GO:0032991) 1.353KCNJ2, KCNH2, KCNQ1
plasma membrane part (GO:0044459) 1.953KCNJ2, KCNQ1, KCNH2
intrinsic component of membrane (GO:0031224) 1.133KCNJ2, KCNQ1, KCNH2
intracellular membrane-bounded organelle (GO:0043231) 0.62KCNJ2, KCNQ1
intracellular organelle (GO:0043229) 0.512KCNJ2, KCNQ1
membrane-bounded organelle (GO:0043227) 0.472KCNJ2, KCNQ1
endoplasmic reticulum (GO:0005783) 2.562KCNJ2, KCNQ1
organelle (GO:0043226) 0.42KCNJ2, KCNQ1

NET-GE enrichment

Term New enriched termICP valueGenes
transmembrane transporter complex (GO:1902495) -4.060.0KCNJ2, KCNH2, KCNQ1
dendritic spine (GO:0043197) NEW5.060.046KCNJ2, KCNQ1
transporter complex (GO:1990351) -4.040.003KCNJ2, KCNH2, KCNQ1
neuron spine (GO:0044309) NEW5.040.049KCNJ2, KCNQ1
cell body (GO:0044297) NEW3.740.017KCNJ2, KCNH2, KCNQ1
voltage-gated potassium channel complex (GO:0008076) -5.340.0KCNJ2, KCNQ1, KCNH2
potassium channel complex (GO:0034705) -5.320.0KCNJ2, KCNQ1, KCNH2
ion channel complex (GO:0034702) -4.180.002KCNJ2, KCNQ1, KCNH2
cation channel complex (GO:0034703) -4.690.0KCNJ2, KCNQ1, KCNH2
neuronal cell body (GO:0043025) NEW3.90.011KCNJ2, KCNH2, KCNQ1