Disease table of VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 1 OMIM ID: 603829

Gene-disease associations table

GeneAssociated with VENTRICULAR FIBRILLATION, PAROXYSMAL FAMILIAL, 1 inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SNTA1ClinVarHGNC link20q11.213PS192500, 603829, 115000
RYR2ClinVarHGNC link1q434115000, PS604772, PS107970, 603829
MYH7ClinVarHGNC link14q11.29PS192600, 160500, PS604169, PS115200, 603829, 255310, 255160, 608358, 181430
KCNH2ClinVarHGNC link7q36.16272120, 603829, PS609620, PS604772, 115000, PS192500
CACNA1CClinVarHGNC link12p13.334PS601144, 603829, 115000, PS192500
VCLClinVarHGNC link10q22.23PS192600, PS115200, 603829
DSPClinVarHGNC link6p24.38607655, 615821, PS604772, 609638, 612908, 605676, PS107970, 603829
JPH2ClinVarHGNC link20q13.122PS192600, 603829
JUPClinVarHGNC link17q21.24601214, PS107970, 115000, 603829
PKP2ClinVarHGNC link12p11.212PS107970, 603829
RBM20ClinVarHGNC link10q25.22PS115200, 603829
SCN5AClinVar, OMIM, HUMSAVARHGNC link3p22.211272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
TTNClinVarHGNC link2q31.28PS192600, PS253600, 600334, PS115200, 603689, 603829, 611705, PS160150

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12p12PKP2, CACNA1C
20q12SNTA1, JPH2
10q22RBM20, VCL
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
20q2SNTA1, JPH2
12p2PKP2, CACNA1C
10q2RBM20, VCL
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102RBM20, VCL
122PKP2, CACNA1C
202SNTA1, JPH2
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KCNH2YES1SP10
JUPYES1DNMT3A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SNTA1RYR2Yes1RYR2
SNTA1CACNA1CNo1RYR2
SNTA1JUPNo1XRCC6
SNTA1SCN5AYes0
RYR2CACNA1CYes3SRI, RYR2, CALM1
RYR2PKP2No1HSPB2
RYR2SCN5ANo3SNTA1, CALM1, ALB
RYR2TTNNo3ALB, CALM1, HSPB2
MYH7VCLNo2YWHAQ, SPTAN1
MYH7DSPNo2SIRT6, WWOX
MYH7JUPNo1WWOX
MYH7PKP2No1YWHAQ
MYH7TTNNo1YWHAQ
KCNH2CACNA1CNo1CUL1
KCNH2VCLNo2NTRK1, YWHAE
KCNH2DSPNo1NTRK1
KCNH2JPH2No1CAV3
KCNH2JUPNo2NTRK1, HSPA4
KCNH2PKP2No1YWHAE
KCNH2SCN5ANo1CAV3
KCNH2TTNNo1NTRK1
CACNA1CVCLNo1VCP
CACNA1CDSPNo3COPS5, CAND1, VCP
CACNA1CJUPNo1COPS5
CACNA1CSCN5ANo1CALM1
CACNA1CTTNNo2CALM1, COPS5
VCLDSPNo6STK24, VCP, CDK2, SEC16A, SIRT7, NTRK1
VCLJUPNo7CDK2, CDH1, MSN, CTNNB1, NTRK1, LIMA1, CTNNA1
VCLPKP2No4YWHAE, SEC16A, YWHAQ, SFN
VCLSCN5ANo1CDK2
VCLTTNNo4NTRK1, EWSR1, YWHAQ, CDK2
DSPJUPYes24WWOX, HNRNPA1, TARDBP, CCDC8, INSIG2, PKP2, PECAM1, CEP128, DYNLL1, COPS5, DSC1, OBSL1, EED, PTEN, CUL2, PKP3, DSP, CDK2, DES, MCM5, CDH5, NTRK1, MCM2, CUL7
DSPPKP2Yes6EED, SEC16A, JUP, DSP, DSC1, CUL3
DSPSCN5ANo1CDK2
DSPTTNNo8NEDD8, CDK2, MCM2, COPS5, CUL3, NTRK1, CUL2, CUL7
JPH2SCN5ANo1CAV3
JUPPKP2Yes8APC, TMEM17, DSC2, EED, DSG2, DSG1, DSC1, DSP
JUPSCN5ANo1CDK2
JUPTTNNo8CDK2, MCM2, CUL4B, COPS5, CUL7, NTRK1, CUL2, FHL2
PKP2TTNNo4CUL3, YWHAQ, HSPB2, RNF2
SCN5ATTNNo4GAN, ALB, CALM1, CDK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
RYR2TTNNo-1CALM1
MYH7VCLNo-12ACTN2, TPM1, MYH11, ACTA2, ACTA1, TPM3, MYL9, HSP90AA1, ACTG2, MYL12B, MYL6B, TPM2
MYH7TTNNo-19ACTN2, TNNI3, TPM1, TNNT2, MYL3, MYL2, TNNC1, MYH8, MYL1, TNNI1, MYH14, MYH3, TNNI2, TNNT3, TNNC2, TPM3, MYH6, MYBPC3, TPM2
VCLDSPNo-2UBC, JUP
VCLJUPYesbinding7CTNNB1, CTNNA3, CTNNA2, CDH1, CTNND1, CDH2, CTNNA1
VCLPKP2No-2GJA1, CTNNB1
VCLTTNYesreaction, binding15ACTN2, TPM1, ACTN1, SOD1, HABP4, WDR1, TPM3, TUBA4A, TLN1, POTEI, PLEK, UBC, BRPF3, TPM4, TPM2
DSPJUPYesbinding3PKP4, DSC1, CDH5
DSPPKP2Yesbinding2DSC1, MYZAP
DSPTTNNo-1UBC
JUPPKP2No-6CTNNB1, DSC2, DSG2, DSP, DSC1, DSG1
JUPTTNNo-1VCL

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
VCLJUPYesPolycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)9ACTN1, PKD1, PTK2, PXN, CDH1, CTNNB1, SRC, BCAR1, TLN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CACNA1CSCN5ANo4CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Arrhythmogenic right ventricular cardiomyopathy (ARVC)hsa054126.325CACNA1C, JUP, PKP2, RYR2, DSP
Hypertrophic cardiomyopathy (HCM)hsa054106.214CACNA1C, TTN, RYR2, MYH7
Dilated cardiomyopathyhsa054146.084CACNA1C, TTN, RYR2, MYH7
Adrenergic signaling in cardiomyocyteshsa042615.444CACNA1C, RYR2, SCN5A, MYH7
Cardiac muscle contractionhsa042606.343CACNA1C, RYR2, MYH7
cGMP-PKG signaling pathwayhsa040225.322CACNA1C, MYH7
Calcium signaling pathwayhsa040205.222CACNA1C, RYR2
cAMP signaling pathwayhsa040245.052CACNA1C, RYR2
Insulin secretionhsa049116.182CACNA1C, RYR2
Circadian entrainmenthsa047136.112CACNA1C, RYR2
Oxytocin signaling pathwayhsa049215.42CACNA1C, RYR2

NET-GE enrichment

Term New enriched termICP valueGenes
Cardiovascular diseasesNEW5.060.0CACNA1C, RYR2, MYH7, TTN, VCL, JUP, PKP2, DSP
Dilated cardiomyopathy (hsa05414) -6.080.0CACNA1C, TTN, RYR2, MYH7
Circulatory systemNEW4.630.017CACNA1C, RYR2, SCN5A, MYH7, KCNH2, SNTA1
Hypertrophic cardiomyopathy (HCM) (hsa05410) -6.210.004CACNA1C, TTN, RYR2, MYH7
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412) -6.320.0CACNA1C, RYR2, VCL, JUP, PKP2, DSP
Cardiac muscle contraction (hsa04260) -6.340.028CACNA1C, RYR2, MYH7
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.0CACNA1C, RYR2, SCN5A, MYH7, KCNH2, SNTA1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Axon guidanceR-HSA-4224753.933CACNA1C, SCN5A, VCL
Developmental BiologyR-HSA-12667383.483CACNA1C, SCN5A, VCL
VEGFA-VEGFR2 PathwayR-HSA-44200974.72JUP, VCL
Platelet degranulation R-HSA-1146086.682TTN, VCL
NCAM signaling for neurite out-growthR-HSA-3751654.92CACNA1C, VCL
Signaling by VEGFR-HSA-1941384.662JUP, VCL
Platelet activation, signaling and aggregationR-HSA-760025.152TTN, VCL
Response to elevated platelet cytosolic Ca2+R-HSA-760056.592TTN, VCL
Muscle contractionR-HSA-3970146.962TTN, VCL
HemostasisR-HSA-1095823.982TTN, VCL
Signal TransductionR-HSA-1625821.782JUP, VCL

NET-GE enrichment

Term New enriched termICP valueGenes
Apoptotic cleavage of cell adhesion proteins (R-HSA-351906) NEW9.520.013JUP, DSP
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1813CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
protein binding (GO:0005515) 0.4612CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
enzyme binding (GO:0019899) 2.279RYR2, SCN5A, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
protein kinase binding (GO:0019901) 3.446RYR2, SCN5A, TTN, JUP, PKP2, DSP
kinase binding (GO:0019900) 3.326RYR2, SCN5A, TTN, JUP, PKP2, DSP
structural molecule activity (GO:0005198) 3.16TTN, VCL, JUP, SNTA1, PKP2, DSP
calmodulin binding (GO:0005516) 4.556CACNA1C, RYR2, SCN5A, MYH7, TTN, SNTA1
cytoskeletal protein binding (GO:0008092) 3.026CACNA1C, SCN5A, MYH7, TTN, VCL, SNTA1
substrate-specific transmembrane transporter activity (GO:0022891) 2.95CACNA1C, KCNH2, RYR2, SCN5A, JPH2
inorganic cation transmembrane transporter activity (GO:0022890) 3.495CACNA1C, SCN5A, RYR2, KCNH2, JPH2
substrate-specific transporter activity (GO:0022892) 2.725CACNA1C, KCNH2, RYR2, SCN5A, JPH2
cation channel activity (GO:0005261) 4.045CACNA1C, KCNH2, RYR2, SCN5A, JPH2
organic cyclic compound binding (GO:0097159) 1.055RBM20, TTN, RYR2, MYH7, DSP
ion channel activity (GO:0005216) 3.715CACNA1C, KCNH2, RYR2, SCN5A, JPH2
cation transmembrane transporter activity (GO:0008324) 3.325CACNA1C, SCN5A, RYR2, KCNH2, JPH2
ion binding (GO:0043167) 1.365CACNA1C, TTN, RYR2, RBM20, JPH2
ion transmembrane transporter activity (GO:0015075) 3.045CACNA1C, KCNH2, RYR2, SCN5A, JPH2
transmembrane transporter activity (GO:0022857) 2.825CACNA1C, SCN5A, RYR2, KCNH2, JPH2
channel activity (GO:0015267) 3.65CACNA1C, KCNH2, RYR2, SCN5A, JPH2
gated channel activity (GO:0022836) 3.965CACNA1C, KCNH2, RYR2, SCN5A, JPH2
transporter activity (GO:0005215) 2.575CACNA1C, SCN5A, RYR2, KCNH2, JPH2
passive transmembrane transporter activity (GO:0022803) 3.65CACNA1C, KCNH2, RYR2, SCN5A, JPH2
metal ion transmembrane transporter activity (GO:0046873) 3.715CACNA1C, KCNH2, RYR2, SCN5A, JPH2
substrate-specific channel activity (GO:0022838) 3.675CACNA1C, SCN5A, RYR2, KCNH2, JPH2
identical protein binding (GO:0042802) 2.635TTN, JUP, KCNH2, RYR2, MYH7
cation binding (GO:0043169) 1.44CACNA1C, TTN, RYR2, RBM20
actin binding (GO:0003779) 3.744TTN, SNTA1, MYH7, VCL
signal transducer activity (GO:0004871) 2.284JUP, KCNH2, RYR2, JPH2
ion channel binding (GO:0044325) 5.024SCN5A, SNTA1, PKP2, RYR2
metal ion binding (GO:0046872) 1.414CACNA1C, TTN, RYR2, RBM20
heterocyclic compound binding (GO:1901363) 1.064RBM20, TTN, MYH7, DSP
ubiquitin-like protein ligase binding (GO:0044389) 4.153KCNH2, SCN5A, VCL
protein binding involved in cell adhesion (GO:0098631) 6.913JUP, PKP2, DSP
protein binding involved in cell-cell adhesion (GO:0098632) 7.343JUP, PKP2, DSP
calcium channel activity (GO:0005262) 5.033CACNA1C, RYR2, JPH2
molecular transducer activity (GO:0060089) 2.323RYR2, KCNH2, JPH2
macromolecular complex binding (GO:0044877) 2.613TTN, PKP2, VCL
receptor activity (GO:0004872) 2.323RYR2, KCNH2, JPH2
protein homodimerization activity (GO:0042803) 3.163JUP, KCNH2, MYH7
divalent inorganic cation transmembrane transporter activity (GO:0072509) 4.623CACNA1C, RYR2, JPH2
nucleoside phosphate binding (GO:1901265) 1.963TTN, RBM20, MYH7
calcium ion transmembrane transporter activity (GO:0015085) 4.893CACNA1C, RYR2, JPH2
ligand-gated ion channel activity (GO:0015276) 4.83RYR2, KCNH2, JPH2
nucleotide binding (GO:0000166) 1.963TTN, MYH7, RBM20
protein complex binding (GO:0032403) 3.093TTN, PKP2, VCL
protein binding involved in heterotypic cell-cell adhesion (GO:0086080) 7.543JUP, PKP2, DSP
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083) 7.953JUP, PKP2, DSP
small molecule binding (GO:0036094) 1.893TTN, MYH7, RBM20
catalytic activity (GO:0003824) 1.053TTN, KCNH2, MYH7
signaling receptor activity (GO:0038023) 2.493RYR2, KCNH2, JPH2
protein domain specific binding (GO:0019904) 3.323KCNH2, SNTA1, SCN5A
cell adhesion molecule binding (GO:0050839) 4.53JUP, DSP, VCL
ubiquitin protein ligase binding (GO:0031625) 4.173KCNH2, SCN5A, VCL
carbohydrate derivative binding (GO:0097367) 2.033TTN, MYH7, VCL
alpha-catenin binding (GO:0045294) 7.443JUP, PKP2, VCL
voltage-gated channel activity (GO:0022832) 4.493CACNA1C, KCNH2, SCN5A
scaffold protein binding (GO:0097110) 5.933KCNH2, SCN5A, DSP
ligand-gated channel activity (GO:0022834) 4.83RYR2, KCNH2, JPH2
protein dimerization activity (GO:0046983) 2.723JUP, KCNH2, MYH7
voltage-gated ion channel activity (GO:0005244) 4.493CACNA1C, KCNH2, SCN5A
transmembrane receptor activity (GO:0099600) 2.533RYR2, KCNH2, JPH2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222TTN, MYH7
protein kinase C binding (GO:0005080) 5.832PKP2, DSP
transmembrane signaling receptor activity (GO:0004888) 2.572RYR2, JPH2
protein kinase activity (GO:0004672) 3.272TTN, KCNH2
nucleic acid binding (GO:0003676) 1.442DSP, RBM20
molecular function regulator (GO:0098772) 2.512SNTA1, PKP2
purine nucleoside binding (GO:0001883) 2.222TTN, MYH7
nucleoside binding (GO:0001882) 2.212TTN, MYH7
calcium-release channel activity (GO:0015278) 6.972RYR2, JPH2
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.872KCNH2, SCN5A
transferase activity (GO:0016740) 1.952TTN, KCNH2
calcium ion binding (GO:0005509) 3.172TTN, RYR2
ribonucleoside binding (GO:0032549) 2.222TTN, MYH7
channel regulator activity (GO:0016247) 4.882SNTA1, PKP2
actinin binding (GO:0042805) 6.32CACNA1C, TTN
ATP binding (GO:0005524) 2.432TTN, MYH7
voltage-gated cation channel activity (GO:0022843) 4.832CACNA1C, KCNH2
alpha-actinin binding (GO:0051393) 6.62CACNA1C, TTN
kinase activity (GO:0016301) 2.932TTN, KCNH2
actin filament binding (GO:0051015) 4.932TTN, VCL
purine nucleotide binding (GO:0017076) 2.192TTN, MYH7
protein self-association (GO:0043621) 5.932TTN, RYR2
nitric-oxide synthase binding (GO:0050998) 6.912SNTA1, SCN5A
adenyl nucleotide binding (GO:0030554) 2.42TTN, MYH7
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082TTN, KCNH2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772TTN, KCNH2
intracellular ligand-gated ion channel activity (GO:0005217) 6.412RYR2, JPH2
cadherin binding (GO:0045296) 6.412JUP, VCL
sodium channel regulator activity (GO:0017080) 6.32SNTA1, PKP2
adenyl ribonucleotide binding (GO:0032559) 2.412TTN, MYH7
RNA binding (GO:0003723) 2.362RBM20, DSP
purine ribonucleotide binding (GO:0032555) 2.22TTN, MYH7
ligand-gated calcium channel activity (GO:0099604) 6.972RYR2, JPH2
purine ribonucleoside binding (GO:0032550) 2.222TTN, MYH7
ribonucleotide binding (GO:0032553) 2.192TTN, MYH7

NET-GE enrichment

Term New enriched termICP valueGenes
cation channel activity (GO:0005261) -4.040.001CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
calcium channel activity (GO:0005262) -5.030.01CACNA1C, RYR2, JPH2
protein kinase C binding (GO:0005080) -5.830.011PKP2, DSP, VCL
enzyme binding (GO:0019899) -2.270.0CACNA1C, RYR2, SCN5A, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
ion channel binding (GO:0044325) -5.020.0CACNA1C, RYR2, SCN5A, KCNH2, SNTA1, PKP2
divalent inorganic cation transmembrane transporter activity (GO:0072509) -4.620.032CACNA1C, RYR2, JPH2
ankyrin binding (GO:0030506) NEW6.740.017TTN, RYR2, SCN5A
calcium ion transmembrane transporter activity (GO:0015085) -4.890.017CACNA1C, RYR2, JPH2
calcium-release channel activity (GO:0015278) -6.970.009CACNA1C, RYR2, JPH2
ligand-gated ion channel activity (GO:0015276) -4.80.026RYR2, KCNH2, JPH2
structural molecule activity (GO:0005198) -3.10.015RYR2, TTN, JPH2, JUP, VCL, PKP2, DSP
actin binding (GO:0003779) -3.740.025RYR2, SCN5A, MYH7, TTN, VCL, SNTA1, DSP
voltage-gated cation channel activity (GO:0022843) -4.830.026CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
channel inhibitor activity (GO:0016248) NEW6.130.004KCNH2, RYR2, SCN5A
channel regulator activity (GO:0016247) -4.880.01KCNH2, RYR2, SCN5A, PKP2
passive transmembrane transporter activity (GO:0022803) -3.60.002CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, SNTA1
metal ion transmembrane transporter activity (GO:0046873) -3.710.001CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
gated channel activity (GO:0022836) -3.960.0CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
alpha-actinin binding (GO:0051393) -6.60.015CACNA1C, TTN, RYR2, VCL
intermediate filament binding (GO:0019215) NEW7.10.009PKP2, DSP
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.017CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
ATPase binding (GO:0051117) NEW5.410.012RYR2, SCN5A, SNTA1
ion channel activity (GO:0005216) -3.710.001CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
cation transmembrane transporter activity (GO:0008324) -3.320.01CACNA1C, SCN5A, RYR2, KCNH2, JPH2
beta-catenin binding (GO:0008013) NEW5.30.033CACNA1C, JUP, VCL
protein kinase binding (GO:0019901) -3.440.003RYR2, SCN5A, TTN, VCL, JUP, PKP2, DSP
kinase binding (GO:0019900) -3.320.007RYR2, SCN5A, TTN, VCL, JUP, PKP2, DSP
actinin binding (GO:0042805) -6.30.024CACNA1C, TTN, RYR2, VCL
cell adhesion molecule binding (GO:0050839) -4.50.035JUP, DSP, VCL
ion channel inhibitor activity (GO:0008200) NEW6.150.004KCNH2, RYR2, SCN5A
nitric-oxide synthase binding (GO:0050998) -6.910.01SNTA1, SCN5A
voltage-gated ion channel activity (GO:0005244) -4.490.001CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
cytoskeletal protein binding (GO:0008092) -3.020.001CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1, DSP
muscle alpha-actinin binding (GO:0051371) NEW7.540.017TTN, VCL
alpha-catenin binding (GO:0045294) -7.440.002JUP, VCL
cadherin binding (GO:0045296) -6.410.03JUP, VCL
ion transmembrane transporter activity (GO:0015075) -3.040.04CACNA1C, KCNH2, RYR2, SCN5A, JPH2
voltage-gated channel activity (GO:0022832) -4.490.001CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
channel activity (GO:0015267) -3.60.002CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, SNTA1
scaffold protein binding (GO:0097110) -5.930.005RYR2, SCN5A, DSP
calmodulin binding (GO:0005516) -4.550.0CACNA1C, RYR2, SCN5A, MYH7, TTN, SNTA1
ligand-gated channel activity (GO:0022834) -4.80.026RYR2, KCNH2, JPH2
substrate-specific channel activity (GO:0022838) -3.670.006CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3913CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
regulation of biological process (GO:0050789) 0.4513CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
cellular process (GO:0009987) 0.2612CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, PKP2, DSP
single-organism process (GO:0044699) 0.4812CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, PKP2, DSP
regulation of cellular process (GO:0050794) 0.512CACNA1C, RYR2, SCN5A, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
multicellular organismal process (GO:0032501) 1.4511CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
single-organism cellular process (GO:0044763) 0.6511CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, PKP2, DSP
developmental process (GO:0032502) 1.3610CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, JUP, RBM20, PKP2, DSP
regulation of biological quality (GO:0065008) 1.6810CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JPH2, JUP, SNTA1, PKP2, DSP
regulation of localization (GO:0032879) 1.9410CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
localization (GO:0051179) 1.410CACNA1C, RYR2, SCN5A, TTN, KCNH2, JPH2, JUP, VCL, PKP2, DSP
regulation of multicellular organismal process (GO:0051239) 1.8710CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JPH2, JUP, SNTA1, PKP2, DSP
regulation of heart contraction (GO:0008016) 4.359CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of system process (GO:0044057) 3.539CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
anatomical structure development (GO:0048856) 1.589CACNA1C, RYR2, SCN5A, MYH7, TTN, JUP, RBM20, PKP2, DSP
single-organism developmental process (GO:0044767) 1.499CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, RBM20, PKP2, DSP
regulation of heart rate (GO:0002027) 5.299CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of blood circulation (GO:1903522) 4.059CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
establishment of localization (GO:0051234) 1.489CACNA1C, RYR2, SCN5A, TTN, KCNH2, JPH2, JUP, VCL, PKP2
regulation of transport (GO:0051049) 2.248CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, SNTA1, PKP2
anatomical structure morphogenesis (GO:0009653) 2.538CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, PKP2, DSP
regulation of membrane potential (GO:0042391) 3.898CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
single organism signaling (GO:0044700) 3.257CACNA1C, RYR2, SCN5A, KCNH2, JUP, PKP2, DSP
regulation of cellular component movement (GO:0051270) 3.087CACNA1C, RYR2, SCN5A, VCL, JUP, PKP2, DSP
muscle contraction (GO:0006936) 4.377RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
single-multicellular organism process (GO:0044707) 1.787CACNA1C, RYR2, SCN5A, KCNH2, JUP, PKP2, DSP
regulation of muscle contraction (GO:0006937) 4.757CACNA1C, RYR2, SCN5A, MYH7, JUP, PKP2, DSP
transport (GO:0006810) 1.517CACNA1C, RYR2, SCN5A, TTN, KCNH2, JPH2, VCL
regulation of metal ion transport (GO:0010959) 3.947CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1, PKP2
muscle system process (GO:0003012) 4.187RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
regulation of striated muscle contraction (GO:0006942) 5.387CACNA1C, RYR2, SCN5A, MYH7, JUP, PKP2, DSP
signaling (GO:0023052) 3.257CACNA1C, RYR2, SCN5A, KCNH2, JUP, PKP2, DSP
regulation of muscle system process (GO:0090257) 4.517CACNA1C, RYR2, SCN5A, MYH7, JUP, PKP2, DSP
positive regulation of biological process (GO:0048518) 1.27RYR2, SCN5A, KCNH2, JPH2, JUP, PKP2, RBM20
single-organism localization (GO:1902578) 2.097CACNA1C, RYR2, TTN, KCNH2, JPH2, JUP, VCL
regulation of ion transport (GO:0043269) 3.47CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1, PKP2
system process (GO:0003008) 2.37RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
multicellular organismal signaling (GO:0035637) 5.366CACNA1C, SCN5A, KCNH2, JUP, PKP2, DSP
action potential (GO:0001508) 5.426CACNA1C, RYR2, SCN5A, KCNH2, SNTA1, PKP2
regulation of ion transmembrane transport (GO:0034765) 3.776CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
regulation of transmembrane transport (GO:0034762) 3.746CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
regulation of cardiac muscle cell contraction (GO:0086004) 6.516CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
cardiac muscle cell action potential (GO:0086001) 6.336CACNA1C, RYR2, SCN5A, KCNH2, SNTA1, PKP2
cardiac muscle cell action potential involved in contraction (GO:0086002) 6.476CACNA1C, RYR2, SCN5A, KCNH2, SNTA1, PKP2
cardiac conduction (GO:0061337) 5.546CACNA1C, SCN5A, KCNH2, JUP, PKP2, DSP
animal organ development (GO:0048513) 2.536CACNA1C, MYH7, JUP, DSP, PKP2, RBM20
regulation of action potential (GO:0098900) 6.076CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
negative regulation of biological process (GO:0048519) 1.336RYR2, KCNH2, JPH2, VCL, PKP2, SNTA1
tissue morphogenesis (GO:0048729) 3.876RYR2, MYH7, TTN, VCL, PKP2, DSP
regulation of actin filament-based movement (GO:1903115) 6.336CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
positive regulation of transport (GO:0051050) 2.96RYR2, SCN5A, KCNH2, JPH2, JUP, PKP2
regulation of actin filament-based process (GO:0032970) 3.976CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
single-organism transport (GO:0044765) 2.186CACNA1C, RYR2, TTN, KCNH2, JPH2, VCL
regulation of cardiac muscle contraction (GO:0055117) 5.576CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
response to stimulus (GO:0050896) 1.226RYR2, SCN5A, TTN, KCNH2, JUP, DSP
regulation of cation transmembrane transport (GO:1904062) 4.46CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
regulation of heart rate by cardiac conduction (GO:0086091) 6.336CACNA1C, SCN5A, KCNH2, JUP, PKP2, DSP
negative regulation of cellular process (GO:0048523) 1.416RYR2, KCNH2, JPH2, VCL, PKP2, SNTA1
positive regulation of cellular process (GO:0048522) 1.36RYR2, SCN5A, KCNH2, JPH2, JUP, RBM20
regulation of primary metabolic process (GO:0080090) 1.085RBM20, TTN, JUP, RYR2, SNTA1
regulation of metabolic process (GO:0019222) 1.025RBM20, TTN, JUP, RYR2, SNTA1
regulation of cellular metabolic process (GO:0031323) 1.075RBM20, TTN, JUP, RYR2, SNTA1
homeostatic process (GO:0042592) 2.615CACNA1C, RYR2, KCNH2, PKP2, JPH2
cardiac muscle contraction (GO:0060048) 5.885TTN, SCN5A, RYR2, KCNH2, MYH7
cellular component organization or biogenesis (GO:0071840) 1.225TTN, JUP, PKP2, DSP, VCL
ventricular cardiac muscle cell action potential (GO:0086005) 7.025PKP2, SCN5A, SNTA1, KCNH2, RYR2
cellular component organization (GO:0016043) 1.245TTN, JUP, PKP2, DSP, VCL
organic substance metabolic process (GO:0071704) 0.635TTN, DSP, KCNH2, MYH7, RBM20
inorganic cation transmembrane transport (GO:0098662) 3.555CACNA1C, SCN5A, RYR2, KCNH2, JPH2
regulation of cardiac muscle cell action potential (GO:0098901) 6.785CACNA1C, JUP, PKP2, RYR2, DSP
cardiac muscle tissue morphogenesis (GO:0055008) 5.85TTN, MYH7, RYR2, PKP2, DSP
cation transport (GO:0006812) 3.115CACNA1C, KCNH2, RYR2, SCN5A, JPH2
ion transport (GO:0006811) 2.665CACNA1C, SCN5A, RYR2, KCNH2, JPH2
inorganic ion transmembrane transport (GO:0098660) 3.385CACNA1C, KCNH2, RYR2, SCN5A, JPH2
positive regulation of ion transport (GO:0043270) 4.365KCNH2, RYR2, SCN5A, PKP2, JPH2
ion transmembrane transport (GO:0034220) 3.085CACNA1C, KCNH2, RYR2, SCN5A, JPH2
metal ion transport (GO:0030001) 3.365CACNA1C, KCNH2, RYR2, SCN5A, JPH2
metabolic process (GO:0008152) 0.585TTN, RBM20, KCNH2, MYH7, DSP
response to chemical (GO:0042221) 1.985TTN, KCNH2, RYR2, SCN5A, JUP
transmembrane transport (GO:0055085) 2.725CACNA1C, SCN5A, RYR2, KCNH2, JPH2
striated muscle contraction (GO:0006941) 5.375TTN, SCN5A, RYR2, KCNH2, MYH7
primary metabolic process (GO:0044238) 0.695TTN, RBM20, KCNH2, MYH7, DSP
regulation of macromolecule metabolic process (GO:0060255) 1.085RYR2, TTN, SNTA1, JUP, RBM20
cellular metabolic process (GO:0044237) 0.695DSP, TTN, KCNH2, MYH7, RBM20
chemical homeostasis (GO:0048878) 2.975CACNA1C, RYR2, KCNH2, PKP2, JPH2
regulation of ventricular cardiac muscle cell action potential (GO:0098911) 7.335CACNA1C, RYR2, PKP2, JUP, DSP
cation transmembrane transport (GO:0098655) 3.435CACNA1C, SCN5A, RYR2, KCNH2, JPH2
muscle tissue morphogenesis (GO:0060415) 5.625TTN, RYR2, PKP2, DSP, MYH7
cellular component assembly (GO:0022607) 2.144TTN, JUP, PKP2, VCL
single organismal cell-cell adhesion (GO:0016337) 3.694DSP, JUP, PKP2, VCL
regulation of cellular localization (GO:0060341) 3.034CACNA1C, RYR2, JUP, JPH2
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.074MYH7, RYR2, PKP2, DSP
adherens junction organization (GO:0034332) 5.484DSP, JUP, PKP2, VCL
ion homeostasis (GO:0050801) 3.424CACNA1C, RYR2, KCNH2, JPH2
cell junction organization (GO:0034330) 4.514DSP, JUP, PKP2, VCL
movement of cell or subcellular component (GO:0006928) 2.614TTN, JUP, MYH7, VCL
cell adhesion (GO:0007155) 2.824DSP, JUP, PKP2, VCL
signal transduction (GO:0007165) 1.284CACNA1C, RYR2, KCNH2, JUP
cellular response to chemical stimulus (GO:0070887) 2.574KCNH2, JUP, SCN5A, RYR2
regulation of signaling (GO:0023051) 1.724CACNA1C, RYR2, JUP, JPH2
inorganic ion homeostasis (GO:0098771) 3.434CACNA1C, RYR2, KCNH2, JPH2
cell communication involved in cardiac conduction (GO:0086065) 6.734CACNA1C, RYR2, SCN5A, PKP2
cellular response to stimulus (GO:0051716) 1.974KCNH2, RYR2, SCN5A, JUP
regulation of cell communication (GO:0010646) 1.734CACNA1C, JUP, RYR2, JPH2
cellular macromolecule metabolic process (GO:0044260) 0.934TTN, KCNH2, RBM20, DSP
regulation of molecular function (GO:0065009) 1.784TTN, JUP, RYR2, JPH2
biological adhesion (GO:0022610) 2.814DSP, JUP, PKP2, VCL
single organism cell adhesion (GO:0098602) 3.634DSP, JUP, PKP2, VCL
cell-cell adhesion (GO:0098609) 3.344DSP, JUP, PKP2, VCL
homotypic cell-cell adhesion (GO:0034109) 5.764DSP, JUP, PKP2, VCL
cell-cell junction organization (GO:0045216) 4.664DSP, JUP, PKP2, VCL
metal ion homeostasis (GO:0055065) 3.614CACNA1C, RYR2, KCNH2, JPH2
cation homeostasis (GO:0055080) 3.464CACNA1C, RYR2, KCNH2, JPH2
cell communication (GO:0007154) 3.044CACNA1C, RYR2, SCN5A, PKP2
regulation of homeostatic process (GO:0032844) 3.654CACNA1C, RYR2, SCN5A, JPH2
organelle organization (GO:0006996) 2.024TTN, JUP, PKP2, DSP
heart development (GO:0007507) 4.244CACNA1C, PKP2, RBM20, MYH7
cytoskeleton organization (GO:0007010) 3.224TTN, JUP, PKP2, DSP
macromolecule metabolic process (GO:0043170) 0.834TTN, KCNH2, DSP, RBM20
single-organism organelle organization (GO:1902589) 2.684TTN, JUP, PKP2, DSP
regulation of ion homeostasis (GO:2000021) 4.444CACNA1C, RYR2, SCN5A, JPH2
cellular homeostasis (GO:0019725) 3.233CACNA1C, RYR2, JPH2
regulation of RNA metabolic process (GO:0051252) 1.523JUP, RYR2, RBM20
heterotypic cell-cell adhesion (GO:0034113) 6.433JUP, PKP2, DSP
cellular cation homeostasis (GO:0030003) 3.63CACNA1C, RYR2, JPH2
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) 6.843KCNH2, SNTA1, SCN5A
regulation of membrane repolarization (GO:0060306) 6.43KCNH2, SNTA1, SCN5A
regulation of calcium ion transmembrane transport (GO:1903169) 4.983CACNA1C, RYR2, JPH2
positive regulation of cytosolic calcium ion concentration (GO:0007204) 4.563CACNA1C, RYR2, JPH2
membrane depolarization (GO:0051899) 5.623CACNA1C, KCNH2, SCN5A
cell-cell junction assembly (GO:0007043) 5.423JUP, PKP2, VCL
calcium ion homeostasis (GO:0055074) 3.973CACNA1C, RYR2, JPH2
positive regulation of transmembrane transport (GO:0034764) 4.993RYR2, KCNH2, JPH2
cell communication by electrical coupling (GO:0010644) 7.023CACNA1C, RYR2, PKP2
intracellular signal transduction (GO:0035556) 2.393CACNA1C, RYR2, KCNH2
positive regulation of ion transmembrane transport (GO:0034767) 5.053RYR2, KCNH2, JPH2
regulation of response to stimulus (GO:0048583) 1.543JUP, MYH7, JPH2
cell communication by electrical coupling involved in cardiac conduction (GO:0086064) 7.163CACNA1C, RYR2, PKP2
regulation of sequestering of calcium ion (GO:0051282) 5.073CACNA1C, RYR2, JPH2
cellular protein metabolic process (GO:0044267) 1.633TTN, KCNH2, DSP
membrane depolarization during action potential (GO:0086010) 6.073CACNA1C, KCNH2, SCN5A
cellular divalent inorganic cation homeostasis (GO:0072503) 3.963CACNA1C, RYR2, JPH2
response to mechanical stimulus (GO:0009612) 4.413TTN, JUP, RYR2
regulation of calcium ion import (GO:0090279) 5.083CACNA1C, RYR2, JPH2
cellular metal ion homeostasis (GO:0006875) 3.753CACNA1C, RYR2, JPH2
positive regulation of molecular function (GO:0044093) 2.233JUP, RYR2, JPH2
response to calcium ion (GO:0051592) 4.983TTN, RYR2, SCN5A
regulation of gene expression (GO:0010468) 1.373JUP, RYR2, RBM20
regulation of calcium ion transport into cytosol (GO:0010522) 5.233CACNA1C, RYR2, JPH2
regulation of cell proliferation (GO:0042127) 2.413JUP, SCN5A, PKP2
cytosolic calcium ion transport (GO:0060401) 5.743CACNA1C, RYR2, JPH2
calcium ion transport into cytosol (GO:0060402) 5.783CACNA1C, RYR2, JPH2
divalent inorganic cation homeostasis (GO:0072507) 3.93CACNA1C, RYR2, JPH2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433JUP, RYR2, RBM20
cellular calcium ion homeostasis (GO:0006874) 4.013CACNA1C, RYR2, JPH2
calcium ion transport (GO:0006816) 4.333CACNA1C, RYR2, JPH2
cellular ion homeostasis (GO:0006873) 3.573CACNA1C, RYR2, JPH2
establishment of protein localization (GO:0045184) 2.533JUP, PKP2, RYR2
macromolecule modification (GO:0043412) 1.733TTN, KCNH2, DSP
protein modification process (GO:0036211) 1.793TTN, KCNH2, DSP
cellular protein modification process (GO:0006464) 1.793TTN, KCNH2, DSP
response to metal ion (GO:0010038) 3.913TTN, RYR2, SCN5A
establishment of localization in cell (GO:0051649) 2.473CACNA1C, RYR2, JPH2
desmosome organization (GO:0002934) 7.533JUP, PKP2, DSP
divalent metal ion transport (GO:0070838) 4.153CACNA1C, RYR2, JPH2
cellular chemical homeostasis (GO:0055082) 3.43CACNA1C, RYR2, JPH2
response to inorganic substance (GO:0010035) 3.563TTN, RYR2, SCN5A
cell junction assembly (GO:0034329) 4.863JUP, PKP2, VCL
bundle of His cell-Purkinje myocyte adhesion involved in cell communication (GO:0086073) 7.943JUP, PKP2, DSP
response to abiotic stimulus (GO:0009628) 2.83TTN, JUP, RYR2
divalent inorganic cation transport (GO:0072511) 4.133CACNA1C, RYR2, JPH2
detection of stimulus (GO:0051606) 3.223TTN, JUP, RYR2
response to external stimulus (GO:0009605) 2.553TTN, JUP, RYR2
protein metabolic process (GO:0019538) 1.453TTN, KCNH2, DSP
regulation of release of sequestered calcium ion into cytosol (GO:0051279) 5.443CACNA1C, RYR2, JPH2
regulation of calcium ion transport (GO:0051924) 4.383CACNA1C, RYR2, JPH2
calcium ion transmembrane transport (GO:0070588) 4.673CACNA1C, RYR2, JPH2
cardiac muscle cell-cardiac muscle cell adhesion (GO:0086042) 7.943JUP, PKP2, DSP
regulation of cytosolic calcium ion concentration (GO:0051480) 4.413CACNA1C, RYR2, JPH2
phosphate-containing compound metabolic process (GO:0006796) 2.163TTN, KCNH2, MYH7
regulation of cardiac muscle cell membrane repolarization (GO:0099623) 6.683KCNH2, SNTA1, SCN5A
regulation of sodium ion transport (GO:0002028) 5.43SNTA1, SCN5A, PKP2
phosphorus metabolic process (GO:0006793) 2.153TTN, KCNH2, MYH7
positive regulation of cation transmembrane transport (GO:1904064) 5.173RYR2, KCNH2, JPH2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363JUP, RYR2, RBM20
protein localization (GO:0008104) 2.362DSP, VCL
positive regulation of response to stimulus (GO:0048584) 2.182JUP, JPH2
positive regulation of homeostatic process (GO:0032846) 4.382RYR2, JPH2
negative regulation of homeostatic process (GO:0032845) 4.912RYR2, JPH2
membrane depolarization during AV node cell action potential (GO:0086045) 8.342CACNA1C, SCN5A
membrane depolarization during cardiac muscle cell action potential (GO:0086012) 7.092CACNA1C, SCN5A
establishment of protein localization to plasma membrane (GO:0090002) 5.22JUP, PKP2
organic cyclic compound metabolic process (GO:1901360) 1.262RBM20, MYH7
single-organism metabolic process (GO:0044710) 1.632KCNH2, MYH7
regulation of signal transduction (GO:0009966) 1.842JUP, JPH2
positive regulation of signal transduction (GO:0009967) 2.52JUP, JPH2
release of sequestered calcium ion into cytosol (GO:0051209) 6.042RYR2, JPH2
cellular developmental process (GO:0048869) 1.822TTN, DSP
phosphorylation (GO:0016310) 2.632TTN, KCNH2
macromolecule localization (GO:0033036) 2.342DSP, VCL
regulation of sodium ion transmembrane transport (GO:1902305) 5.862SNTA1, SCN5A
calcium-mediated signaling (GO:0019722) 5.242CACNA1C, RYR2
negative regulation of sequestering of calcium ion (GO:0051283) 6.042RYR2, JPH2
muscle filament sliding (GO:0030049) 6.092TTN, MYH7
actin filament-based movement (GO:0030048) 5.542TTN, MYH7
calcium ion import into cytosol (GO:1902656) 5.992RYR2, JPH2
regulation of RNA biosynthetic process (GO:2001141) 1.552JUP, RYR2
response to organic substance (GO:0010033) 2.22JUP, RYR2
heterocycle metabolic process (GO:0046483) 1.312RBM20, MYH7
intermediate filament organization (GO:0045109) 6.732PKP2, DSP
intermediate filament cytoskeleton organization (GO:0045104) 6.042PKP2, DSP
response to organonitrogen compound (GO:0010243) 3.22JUP, RYR2
intermediate filament-based process (GO:0045103) 6.022PKP2, DSP
positive regulation of heart contraction (GO:0045823) 6.152RYR2, SCN5A
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) 6.682CACNA1C, RYR2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881) 6.92CACNA1C, RYR2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) 6.592CACNA1C, RYR2
positive regulation of ion transmembrane transporter activity (GO:0032414) 5.552RYR2, JPH2
positive regulation of transporter activity (GO:0032411) 5.442RYR2, JPH2
regulation of ion transmembrane transporter activity (GO:0032412) 4.552RYR2, JPH2
detection of external stimulus (GO:0009581) 4.982TTN, JUP
detection of abiotic stimulus (GO:0009582) 4.962TTN, JUP
secretion by cell (GO:0032940) 3.592TTN, VCL
nitrogen compound metabolic process (GO:0006807) 1.132RBM20, MYH7
second-messenger-mediated signaling (GO:0019932) 4.652CACNA1C, RYR2
regulation of protein transport (GO:0051223) 3.122CACNA1C, JUP
response to muscle stretch (GO:0035994) 6.782TTN, RYR2
exocytosis (GO:0006887) 4.112TTN, VCL
regulated exocytosis (GO:0045055) 4.442TTN, VCL
macromolecular complex assembly (GO:0065003) 2.552TTN, JUP
positive regulation of calcium ion transmembrane transport (GO:1904427) 5.692RYR2, JPH2
calcium ion transmembrane import into cytosol (GO:0097553) 5.992RYR2, JPH2
regulation of establishment of protein localization (GO:0070201) 3.022CACNA1C, JUP
regulation of catalytic activity (GO:0050790) 1.972TTN, RYR2
regulation of biosynthetic process (GO:0009889) 1.372JUP, RYR2
positive regulation of blood circulation (GO:1903524) 5.162RYR2, SCN5A
secretion (GO:0046903) 3.382TTN, VCL
regulation of transmembrane transporter activity (GO:0022898) 4.522RYR2, JPH2
response to nitrogen compound (GO:1901698) 3.122JUP, RYR2
cellular response to nitrogen compound (GO:1901699) 3.792JUP, RYR2
response to stress (GO:0006950) 1.82RYR2, DSP
regulation of transcription, DNA-templated (GO:0006355) 1.562JUP, RYR2
muscle hypertrophy (GO:0014896) 6.682TTN, RYR2
striated muscle hypertrophy (GO:0014897) 6.782TTN, RYR2
regulation of cell motility (GO:2000145) 3.162PKP2, VCL
negative regulation of cell motility (GO:2000146) 4.362PKP2, VCL
cardiac muscle hypertrophy (GO:0003300) 6.842TTN, RYR2
positive regulation of signaling (GO:0023056) 2.412JUP, JPH2
cellular nitrogen compound metabolic process (GO:0034641) 1.222RBM20, MYH7
positive regulation of cell communication (GO:0010647) 2.412JUP, JPH2
response to organic cyclic compound (GO:0014070) 3.072JUP, RYR2
regulation of protein localization (GO:0032880) 2.882CACNA1C, JUP
response to endogenous stimulus (GO:0009719) 2.792JUP, RYR2
nucleobase-containing compound metabolic process (GO:0006139) 1.352RBM20, MYH7
positive regulation of multicellular organismal process (GO:0051240) 2.492RYR2, SCN5A
regulation of protein metabolic process (GO:0051246) 1.932TTN, SNTA1
actin-myosin filament sliding (GO:0033275) 6.092TTN, MYH7
regulation of the force of heart contraction (GO:0002026) 6.42RYR2, MYH7
macromolecular complex subunit organization (GO:0043933) 2.142TTN, JUP
regulation of transporter activity (GO:0032409) 4.452RYR2, JPH2
regulation of protein modification process (GO:0031399) 2.322TTN, SNTA1
monovalent inorganic cation transport (GO:0015672) 3.742KCNH2, SCN5A
positive regulation of sodium ion transport (GO:0010765) 6.232PKP2, SCN5A
cellular response to endogenous stimulus (GO:0071495) 3.332JUP, RYR2
regulation of calcium ion transmembrane transporter activity (GO:1901019) 5.492RYR2, JPH2
cellular aromatic compound metabolic process (GO:0006725) 1.32RBM20, MYH7
negative regulation of locomotion (GO:0040013) 4.222PKP2, VCL
regulation of nucleic acid-templated transcription (GO:1903506) 1.552JUP, RYR2
cell-cell signaling involved in cardiac conduction (GO:0086019) 8.122RYR2, PKP2
epithelial cell-cell adhesion (GO:0090136) 7.092JUP, VCL
regulation of cellular protein metabolic process (GO:0032268) 1.992TTN, SNTA1
cellular response to organic cyclic compound (GO:0071407) 3.932JUP, RYR2
adherens junction assembly (GO:0034333) 6.22JUP, VCL
regulation of cellular biosynthetic process (GO:0031326) 1.382JUP, RYR2
morphogenesis of an epithelium (GO:0002009) 4.082RYR2, VCL
protein complex subunit organization (GO:0071822) 2.62TTN, JUP
detection of mechanical stimulus (GO:0050982) 5.942TTN, JUP
platelet degranulation (GO:0002576) 5.122TTN, VCL
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462JUP, RYR2
cellular response to organic substance (GO:0071310) 2.782JUP, RYR2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432JUP, RYR2
positive regulation of calcium ion transmembrane transporter activity (GO:1901021) 6.362RYR2, JPH2
positive regulation of heart rate (GO:0010460) 6.592RYR2, SCN5A
skin development (GO:0043588) 5.842JUP, DSP
embryonic morphogenesis (GO:0048598) 3.722CACNA1C, RYR2
negative regulation of cell migration (GO:0030336) 4.412PKP2, VCL
protein phosphorylation (GO:0006468) 2.892TTN, KCNH2
regulation of cell migration (GO:0030334) 3.232PKP2, VCL
actin filament-based process (GO:0030029) 3.942TTN, MYH7
protein complex assembly (GO:0006461) 2.782TTN, JUP
desmosome assembly (GO:0002159) 8.342JUP, PKP2
cell-cell signaling (GO:0007267) 3.352RYR2, PKP2
calcium ion import (GO:0070509) 5.572RYR2, JPH2
response to oxygen-containing compound (GO:1901700) 2.572JUP, RYR2
cellular response to oxygen-containing compound (GO:1901701) 3.222JUP, RYR2
negative regulation of cellular component movement (GO:0051271) 4.222PKP2, VCL
regulation of locomotion (GO:0040012) 3.122PKP2, VCL
positive regulation of calcium ion transport (GO:0051928) 5.062RYR2, JPH2
establishment of protein localization to membrane (GO:0090150) 4.142JUP, PKP2
actin-mediated cell contraction (GO:0070252) 5.882TTN, MYH7
cellular response to organonitrogen compound (GO:0071417) 3.872JUP, RYR2
vesicle-mediated transport (GO:0016192) 2.722TTN, VCL

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.0CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
protein localization (GO:0008104) -2.360.027RYR2, SCN5A, MYH7, KCNH2, VCL, JUP, DSP
single organismal cell-cell adhesion (GO:0016337) -3.690.02DSP, JUP, PKP2, VCL
cell-cell junction organization (GO:0045216) -4.660.003DSP, JUP, PKP2, VCL
calcium ion transport into cytosol (GO:0060402) -5.780.047CACNA1C, RYR2, JPH2
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.0MYH7, RYR2, PKP2, DSP
adherens junction organization (GO:0034332) -5.480.004DSP, JUP, PKP2, VCL
cell junction organization (GO:0034330) -4.510.005DSP, JUP, PKP2, VCL
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) -6.840.0KCNH2, SNTA1, SCN5A
regulation of membrane repolarization (GO:0060306) -6.40.0KCNH2, SNTA1, SCN5A, RYR2
epithelial cell-cell adhesion (GO:0090136) -7.090.029JUP, VCL
striated muscle contraction (GO:0006941) -5.370.0TTN, KCNH2, RYR2, SCN5A, MYH7
cell-cell signaling (GO:0007267) -3.350.031CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, SNTA1, PKP2
membrane depolarization (GO:0051899) -5.620.034CACNA1C, KCNH2, SNTA1, SCN5A
regulation of striated muscle contraction (GO:0006942) -5.380.005CACNA1C, RYR2, SCN5A
cell-cell junction assembly (GO:0007043) -5.420.014DSP, JUP, PKP2, VCL
bundle of His cell to Purkinje myocyte communication (GO:0086069) NEW9.040.0JUP, SCN5A, PKP2, DSP
action potential (GO:0001508) -5.420.0CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of ion transmembrane transport (GO:0034765) -3.770.017CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
cell communication by electrical coupling involved in cardiac conduction (GO:0086064) -7.160.0CACNA1C, RYR2, PKP2
cell communication involved in cardiac conduction (GO:0086065) -6.730.0CACNA1C, RYR2, SCN5A, JUP, PKP2, DSP
cardiac muscle contraction (GO:0060048) -5.880.0TTN, KCNH2, RYR2, SCN5A
single-multicellular organism process (GO:0044707) -1.780.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
regulation of transmembrane transport (GO:0034762) -3.740.026CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1
ventricular cardiac muscle cell action potential (GO:0086005) -7.020.0RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
membrane depolarization during action potential (GO:0086010) -6.070.001CACNA1C, KCNH2, SNTA1, SCN5A
cardiac muscle cell action potential (GO:0086001) -6.330.0RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of system process (GO:0044057) -3.530.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
adult heart development (GO:0007512) NEW7.160.039TTN, MYH7
cardiac conduction (GO:0061337) -5.540.0KCNH2, JUP, SCN5A, PKP2, DSP
regulation of ion transmembrane transporter activity (GO:0032412) -4.550.009CACNA1C, SCN5A, RYR2, KCNH2, JPH2
multicellular organismal signaling (GO:0035637) -5.360.0KCNH2, JUP, SCN5A, PKP2, DSP
inorganic ion transmembrane transport (GO:0098660) -3.380.02CACNA1C, KCNH2, RYR2, SCN5A, JPH2
intermediate filament organization (GO:0045109) -6.730.039PKP2, DSP
regulation of heart rate (GO:0002027) -5.290.0RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of transporter activity (GO:0032409) -4.450.017CACNA1C, KCNH2, RYR2, SCN5A, JPH2
chemical homeostasis (GO:0048878) -2.970.032CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, PKP2, DSP
inorganic cation transmembrane transport (GO:0098662) -3.550.009CACNA1C, SCN5A, RYR2, KCNH2, JPH2
tissue morphogenesis (GO:0048729) -3.870.0RYR2, MYH7, TTN, VCL, JUP, PKP2, DSP
regulation of transport (GO:0051049) -2.240.001CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, SNTA1, PKP2
response to calcium ion (GO:0051592) -4.980.029TTN, RYR2, SCN5A
regulation of biological quality (GO:0065008) -1.680.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
regulation of sodium ion transport (GO:0002028) -5.40.006SNTA1, SCN5A, PKP2
gap junction assembly (GO:0016264) NEW7.650.027JUP, PKP2
single organism cell adhesion (GO:0098602) -3.630.027DSP, JUP, PKP2, VCL
cytosolic calcium ion transport (GO:0060401) -5.740.05CACNA1C, RYR2, JPH2
muscle contraction (GO:0006936) -4.370.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
positive regulation of transport (GO:0051050) -2.90.002RYR2, SCN5A, KCNH2, JPH2, JUP, PKP2
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.0RYR2, MYH7, TTN, JUP, PKP2, DSP
cation transport (GO:0006812) -3.110.021CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JPH2, JUP, SNTA1
multicellular organismal process (GO:0032501) -1.450.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
regulation of heart contraction (GO:0008016) -4.350.0CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of metal ion transport (GO:0010959) -3.940.0CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1, PKP2
regulation of muscle contraction (GO:0006937) -4.750.048CACNA1C, RYR2, SCN5A
cell-cell signaling involved in cardiac conduction (GO:0086019) -8.120.004RYR2, PKP2
intermediate filament bundle assembly (GO:0045110) NEW7.940.022PKP2, DSP
metal ion transport (GO:0030001) -3.360.029CACNA1C, RYR2, SCN5A, MYH7, KCNH2, JPH2, SNTA1
regulation of muscle system process (GO:0090257) -4.510.002CACNA1C, TTN, RYR2, SCN5A, VCL
regulation of multicellular organismal process (GO:0051239) -1.870.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, JPH2, JUP, SNTA1, PKP2, DSP
desmosome assembly (GO:0002159) -8.340.002JUP, PKP2
desmosome organization (GO:0002934) -7.530.0JUP, PKP2, DSP
cell communication (GO:0007154) -3.040.0CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
regulation of localization (GO:0032879) -1.940.0CACNA1C, RYR2, SCN5A, KCNH2, JPH2, JUP, VCL, SNTA1, PKP2
regulation of cardiac muscle contraction (GO:0055117) -5.570.002CACNA1C, RYR2, SCN5A
system process (GO:0003008) -2.30.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
single organism signaling (GO:0044700) -3.250.0CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
heart development (GO:0007507) -4.240.036RBM20, TTN, JUP, PKP2, MYH7
cytoskeleton organization (GO:0007010) -3.220.011RYR2, SCN5A, TTN, VCL, JUP, SNTA1, PKP2, DSP
cardiac muscle cell action potential involved in contraction (GO:0086002) -6.470.0RYR2, SCN5A, KCNH2, JUP, SNTA1, PKP2, DSP
regulation of ion transport (GO:0043269) -3.40.0CACNA1C, RYR2, SCN5A, KCNH2, JPH2, SNTA1, PKP2
muscle system process (GO:0003012) -4.180.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, SNTA1
intermediate filament cytoskeleton organization (GO:0045104) -6.040.013PKP2, DSP, VCL
regulation of transmembrane transporter activity (GO:0022898) -4.520.011CACNA1C, SCN5A, RYR2, KCNH2, JPH2
cell communication by electrical coupling (GO:0010644) -7.020.0CACNA1C, RYR2, PKP2
positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) NEW7.780.04RYR2, JPH2
intermediate filament-based process (GO:0045103) -6.020.014PKP2, DSP, VCL
regulation of heart rate by cardiac conduction (GO:0086091) -6.330.0KCNH2, JUP, SCN5A, PKP2, DSP
anatomical structure morphogenesis (GO:0009653) -2.530.0RYR2, SCN5A, MYH7, TTN, VCL, JUP, PKP2, DSP
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) -6.680.049CACNA1C, RYR2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881) -6.90.039CACNA1C, RYR2
signaling (GO:0023052) -3.250.0CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, SNTA1, PKP2, DSP
cation transmembrane transport (GO:0098655) -3.430.02CACNA1C, KCNH2, RYR2, SCN5A, JPH2
muscle tissue morphogenesis (GO:0060415) -5.620.0RYR2, MYH7, TTN, JUP, PKP2, DSP
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.2813CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
cell part (GO:0044464) 0.1113CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
intracellular organelle (GO:0043229) 0.5112CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
organelle (GO:0043226) 0.412CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, JUP, JPH2, RBM20, SNTA1, PKP2, DSP
protein complex (GO:0043234) 1.5110CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, SNTA1
macromolecular complex (GO:0032991) 1.3510CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, VCL, JUP, JPH2, SNTA1
membrane (GO:0016020) 0.6810CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
plasma membrane (GO:0005886) 1.3910CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
membrane part (GO:0044425) 0.9510CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
organelle part (GO:0044422) 0.7910CACNA1C, RYR2, SCN5A, MYH7, TTN, JPH2, JUP, VCL, PKP2, DSP
cytoplasmic part (GO:0044444) 0.829CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, JPH2, JUP, VCL
membrane-bounded organelle (GO:0043227) 0.479RBM20, RYR2, SCN5A, TTN, JPH2, JUP, VCL, PKP2, DSP
intracellular organelle part (GO:0044446) 0.818RYR2, MYH7, TTN, JPH2, JUP, VCL, PKP2, DSP
intracellular membrane-bounded organelle (GO:0043231) 0.68RYR2, SCN5A, TTN, JPH2, JUP, DSP, PKP2, RBM20
contractile fiber part (GO:0044449) 4.538CACNA1C, RYR2, SCN5A, MYH7, TTN, JPH2, JUP, VCL
cytoplasm (GO:0005737) 1.017CACNA1C, MYH7, TTN, VCL, JUP, SNTA1, DSP
non-membrane-bounded organelle (GO:0043228) 1.767CACNA1C, MYH7, TTN, VCL, JUP, SNTA1, DSP
Z disc (GO:0030018) 5.117CACNA1C, RYR2, SCN5A, MYH7, TTN, JPH2, JUP
intracellular non-membrane-bounded organelle (GO:0043232) 1.767CACNA1C, MYH7, TTN, VCL, JUP, SNTA1, DSP
integral component of membrane (GO:0016021) 1.146CACNA1C, RYR2, SCN5A, KCNH2, JPH2, PKP2
membrane protein complex (GO:0098796) 2.846CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1
cytoskeletal part (GO:0044430) 2.496MYH7, TTN, VCL, JUP, PKP2, DSP
cell junction (GO:0030054) 2.756SCN5A, VCL, JUP, SNTA1, PKP2, DSP
plasma membrane part (GO:0044459) 1.956CACNA1C, SCN5A, KCNH2, JUP, SNTA1, DSP
intrinsic component of membrane (GO:0031224) 1.136CACNA1C, RYR2, SCN5A, KCNH2, JPH2, PKP2
extracellular organelle (GO:0043230) 1.895TTN, DSP, JUP, RYR2, VCL
vesicle (GO:0031982) 1.645TTN, DSP, JUP, RYR2, VCL
nucleus (GO:0005634) 1.075RBM20, TTN, JUP, PKP2, DSP
membrane-bounded vesicle (GO:0031988) 1.715TTN, DSP, JUP, RYR2, VCL
plasma membrane protein complex (GO:0098797) 3.555CACNA1C, KCNH2, JUP, SCN5A, SNTA1
cell-cell junction (GO:0005911) 3.855DSP, JUP, SCN5A, PKP2, VCL
extracellular vesicle (GO:1903561) 1.895TTN, DSP, JUP, RYR2, VCL
extracellular region part (GO:0044421) 1.575TTN, DSP, JUP, RYR2, VCL
extracellular exosome (GO:0070062) 1.895TTN, DSP, JUP, RYR2, VCL
cytoskeleton (GO:0005856) 2.554DSP, SNTA1, JUP, VCL
transmembrane transporter complex (GO:1902495) 4.064CACNA1C, KCNH2, RYR2, SCN5A
cytosol (GO:0005829) 1.684TTN, JUP, VCL, JPH2
anchoring junction (GO:0070161) 3.614DSP, JUP, PKP2, VCL
transporter complex (GO:1990351) 4.044CACNA1C, KCNH2, RYR2, SCN5A
intracellular (GO:0005622) 2.374KCNH2, RYR2, SCN5A, SNTA1
intercalated disc (GO:0014704) 5.934JUP, SCN5A, PKP2, DSP
ion channel complex (GO:0034702) 4.184CACNA1C, KCNH2, RYR2, SCN5A
cation channel complex (GO:0034703) 4.694CACNA1C, SCN5A, RYR2, KCNH2
cell-cell contact zone (GO:0044291) 5.694JUP, SCN5A, PKP2, DSP
adherens junction (GO:0005912) 3.664DSP, JUP, PKP2, VCL
plasma membrane region (GO:0098590) 2.973JUP, SCN5A, DSP
supramolecular fiber (GO:0099512) 3.313JUP, PKP2, DSP
endoplasmic reticulum (GO:0005783) 2.563RYR2, SCN5A, JPH2
cell-cell adherens junction (GO:0005913) 5.813JUP, DSP, VCL
fascia adherens (GO:0005916) 7.53JUP, DSP, VCL
intermediate filament (GO:0005882) 4.483JUP, PKP2, DSP
nuclear part (GO:0044428) 1.553TTN, JUP, PKP2
lateral plasma membrane (GO:0016328) 5.893SNTA1, SCN5A, JUP
desmosome (GO:0030057) 6.583JUP, PKP2, DSP
polymeric cytoskeletal fiber (GO:0099513) 3.313JUP, PKP2, DSP
actin cytoskeleton (GO:0015629) 4.392JUP, VCL
endoplasmic reticulum membrane (GO:0005789) 2.952RYR2, JPH2
sarcomere (GO:0030017) 5.952RYR2, MYH7
calcium channel complex (GO:0034704) 5.722CACNA1C, RYR2
junctional sarcoplasmic reticulum membrane (GO:0014701) 7.52RYR2, JPH2
cell-substrate adherens junction (GO:0005924) 3.832JUP, VCL
focal adhesion (GO:0005925) 3.832JUP, VCL
cell-substrate junction (GO:0030055) 3.822JUP, VCL
organelle membrane (GO:0031090) 1.972RYR2, JPH2
muscle myosin complex (GO:0005859) 6.862TTN, MYH7
sarcoplasmic reticulum membrane (GO:0033017) 6.142RYR2, JPH2
endoplasmic reticulum part (GO:0044432) 2.732RYR2, JPH2
myosin complex (GO:0016459) 5.552TTN, MYH7
myosin II complex (GO:0016460) 6.542TTN, MYH7
cell surface (GO:0009986) 3.442KCNH2, SCN5A
extracellular region (GO:0005576) 2.182TTN, VCL
sarcolemma (GO:0042383) 5.22SNTA1, SCN5A
bounding membrane of organelle (GO:0098588) 2.392RYR2, JPH2
membrane region (GO:0098589) 3.952SCN5A, VCL
zonula adherens (GO:0005915) 7.612JUP, VCL
membrane raft (GO:0045121) 4.182SCN5A, VCL
cell (GO:0005623) 5.222RYR2, VCL
sarcoplasmic reticulum (GO:0016529) 5.812RYR2, JPH2
membrane microdomain (GO:0098857) 4.172SCN5A, VCL

NET-GE enrichment

Term New enriched termICP valueGenes
plasma membrane region (GO:0098590) -2.970.031CACNA1C, RYR2, VCL, JUP, SNTA1, DSP
intercalated disc (GO:0014704) -5.930.0RYR2, SCN5A, JUP, SNTA1, PKP2, DSP
ion channel complex (GO:0034702) -4.180.003CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
cation channel complex (GO:0034703) -4.690.0CACNA1C, SCN5A, RYR2, KCNH2, SNTA1
side of membrane (GO:0098552) NEW4.220.024CACNA1C, RYR2, SCN5A, JUP, VCL
lateral plasma membrane (GO:0016328) -5.890.044JUP, SCN5A
desmosome (GO:0030057) -6.580.0JUP, PKP2, DSP
Z disc (GO:0030018) -5.110.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, JPH2, JUP
cytoskeleton (GO:0005856) -2.550.043CACNA1C, RYR2, SCN5A, VCL, JUP, SNTA1, DSP
I band (GO:0031674) NEW6.670.001CACNA1C, TTN, RYR2
sarcoplasmic reticulum membrane (GO:0033017) -6.140.027RYR2, JPH2
cytoskeletal part (GO:0044430) -2.490.02CACNA1C, RYR2, SCN5A, MYH7, TTN, VCL, JUP, PKP2, DSP
sarcolemma (GO:0042383) -5.20.002CACNA1C, RYR2, SCN5A, SNTA1
cell junction (GO:0030054) -2.750.0CACNA1C, RYR2, SCN5A, MYH7, VCL, JUP, SNTA1, PKP2, DSP
neuronal cell body (GO:0043025) NEW3.90.003CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1
membrane region (GO:0098589) -3.950.011CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, DSP
transmembrane transporter complex (GO:1902495) -4.060.006CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
T-tubule (GO:0030315) NEW6.090.0CACNA1C, RYR2, SCN5A, SNTA1
transporter complex (GO:1990351) -4.040.006CACNA1C, KCNH2, SNTA1, SCN5A, RYR2
cell-cell contact zone (GO:0044291) -5.690.0RYR2, SCN5A, JUP, SNTA1, PKP2, DSP
anchoring junction (GO:0070161) -3.610.009RYR2, MYH7, VCL, JUP, PKP2, DSP
cell body (GO:0044297) NEW3.740.007CACNA1C, RYR2, SCN5A, KCNH2, JUP, SNTA1
basolateral plasma membrane (GO:0016323) NEW4.560.047DSP, SNTA1, JUP, VCL
fascia adherens (GO:0005916) -7.50.0JUP, DSP, VCL
zonula adherens (GO:0005915) -7.610.009JUP, VCL
cell-cell adherens junction (GO:0005913) -5.810.006JUP, DSP, VCL
adherens junction (GO:0005912) -3.660.001RYR2, MYH7, VCL, JUP, PKP2, DSP
cell-cell junction (GO:0005911) -3.850.004SCN5A, VCL, JUP, SNTA1, PKP2, DSP
plasma membrane (GO:0005886) -1.390.002CACNA1C, RYR2, SCN5A, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2, DSP
junctional sarcoplasmic reticulum membrane (GO:0014701) -7.50.002RYR2, JPH2
protein complex (GO:0043234) -1.510.003CACNA1C, RYR2, SCN5A, MYH7, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2
neuromuscular junction (GO:0031594) NEW5.810.02SNTA1, SCN5A, RYR2
macromolecular complex (GO:0032991) -1.350.016CACNA1C, RYR2, SCN5A, MYH7, KCNH2, VCL, JUP, JPH2, SNTA1, PKP2
axon part (GO:0033267) NEW4.40.045CACNA1C, KCNH2, SCN5A, VCL
contractile fiber part (GO:0044449) -4.530.0CACNA1C, RYR2, SCN5A, MYH7, TTN, KCNH2, JPH2, JUP, VCL
synapse (GO:0045202) NEW3.580.018CACNA1C, SCN5A, RYR2, KCNH2, SNTA1