Disease table of SUDDEN INFANT DEATH SYNDROME OMIM ID: 272120

Gene-disease associations table

GeneAssociated with SUDDEN INFANT DEATH SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SCN5AClinVar, OMIM, HUMSAVARHGNC link3p22.211272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
KCNH2ClinVarHGNC link7q36.16272120, 603829, PS609620, PS604772, 115000, PS192500
KCNJ8HUMSAVARHGNC link12p12.12272120, 115000
KCNQ1ClinVarHGNC link11p15.56115000, 272120, PS609620, PS608583, PS192500, 220400
GPD1LClinVar, HUMSAVARHGNC link3p22.32272120, PS601144
SCN4BClinVarHGNC link11q23.34272120, PS608583, 115000, PS192500
CAV3HUMSAVARHGNC link3p25.37PS192600, 272120, PS192500, 123320, 614321, PS159000, 606072

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
3p222SCN5A, GPD1L
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
3p23CAV3, SCN5A, GPD1L
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
3p3CAV3, SCN5A, GPD1L
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112KCNQ1, SCN4B
33CAV3, SCN5A, GPD1L
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KCNH2YES1SP10
CAV3YES1RORA0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SCN5AKCNH2No1CAV3
SCN5AKCNQ1No1NEDD4
SCN5ACAV3Yes0
KCNH2KCNQ1No3HSPA4, NEDD4L, KCNE1
KCNH2CAV3Yes1NEDD4L
KCNQ1CAV3No1NEDD4L

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
SCN5AKCNQ1No4CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Adrenergic signaling in cardiomyocyteshsa042615.443KCNQ1, SCN5A, SCN4B

NET-GE enrichment

Term New enriched termICP valueGenes
Gastric acid secretion (hsa04971) NEW6.480.007KCNQ1, KCNH2, CAV3
Circulatory systemNEW4.630.0GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.006KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Neuronal SystemR-HSA-1123164.823KCNQ1, KCNJ8, KCNH2
Potassium ChannelsR-HSA-12960716.353KCNQ1, KCNJ8, KCNH2
Voltage gated Potassium channelsR-HSA-12960727.562KCNQ1, KCNH2
Axon guidanceR-HSA-4224753.932SCN5A, SCN4B
Interaction between L1 and AnkyrinsR-HSA-4450958.032SCN5A, SCN4B
L1CAM interactionsR-HSA-3737606.192SCN5A, SCN4B
Developmental BiologyR-HSA-12667383.482SCN5A, SCN4B

NET-GE enrichment

Term New enriched termICP valueGenes
Neuronal System (R-HSA-112316) -4.820.044KCNQ1, KCNH2, KCNJ8, CAV3
Interaction between L1 and Ankyrins (R-HSA-445095) -8.030.005SCN5A, SCN4B
Voltage gated Potassium channels (R-HSA-1296072) -7.560.01KCNH2, KCNQ1
Potassium Channels (R-HSA-1296071) -6.350.001KCNQ1, KCNH2, KCNJ8, CAV3
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
protein binding (GO:0005515) 0.467GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
substrate-specific transmembrane transporter activity (GO:0022891) 2.95KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
inorganic cation transmembrane transporter activity (GO:0022890) 3.495KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
substrate-specific transporter activity (GO:0022892) 2.725KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
cation channel activity (GO:0005261) 4.045KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
substrate-specific channel activity (GO:0022838) 3.675KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
transporter activity (GO:0005215) 2.575KCNJ8, SCN4B, SCN5A, KCNH2, KCNQ1
ion channel activity (GO:0005216) 3.715KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
cation transmembrane transporter activity (GO:0008324) 3.325KCNJ8, SCN4B, SCN5A, KCNH2, KCNQ1
transmembrane transporter activity (GO:0022857) 2.825KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
ion transmembrane transporter activity (GO:0015075) 3.045KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
voltage-gated channel activity (GO:0022832) 4.495KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.875KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
channel activity (GO:0015267) 3.65KCNJ8, SCN4B, SCN5A, KCNH2, KCNQ1
gated channel activity (GO:0022836) 3.965KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
passive transmembrane transporter activity (GO:0022803) 3.65KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
ion channel binding (GO:0044325) 5.025KCNQ1, SCN5A, SCN4B, CAV3, GPD1L
voltage-gated ion channel activity (GO:0005244) 4.495KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
metal ion transmembrane transporter activity (GO:0046873) 3.715KCNJ8, SCN4B, SCN5A, KCNH2, KCNQ1
enzyme binding (GO:0019899) 2.274KCNQ1, SCN5A, CAV3, KCNH2
potassium channel activity (GO:0005267) 4.943KCNQ1, KCNJ8, KCNH2
sodium channel regulator activity (GO:0017080) 6.33GPD1L, SCN4B, CAV3
scaffold protein binding (GO:0097110) 5.933KCNQ1, SCN5A, KCNH2
voltage-gated cation channel activity (GO:0022843) 4.833KCNQ1, KCNJ8, KCNH2
voltage-gated potassium channel activity (GO:0005249) 5.243KCNQ1, KCNH2, KCNJ8
channel regulator activity (GO:0016247) 4.883GPD1L, SCN4B, CAV3
molecular function regulator (GO:0098772) 2.513GPD1L, SCN4B, CAV3
potassium ion transmembrane transporter activity (GO:0015079) 4.773KCNQ1, KCNJ8, KCNH2
ubiquitin-like protein ligase binding (GO:0044389) 4.152KCNH2, SCN5A
molecular transducer activity (GO:0060089) 2.322KCNH2, KCNJ8
receptor activity (GO:0004872) 2.322KCNH2, KCNJ8
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) 6.742SCN5A, SCN4B
heterocyclic compound binding (GO:1901363) 1.062GPD1L, KCNJ8
nucleoside phosphate binding (GO:1901265) 1.962GPD1L, KCNJ8
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) 8.132SCN5A, SCN4B
sodium ion transmembrane transporter activity (GO:0015081) 4.832SCN5A, SCN4B
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) 7.792KCNQ1, KCNH2
ligand-gated ion channel activity (GO:0015276) 4.82KCNH2, KCNJ8
nucleotide binding (GO:0000166) 1.962GPD1L, KCNJ8
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) 8.352KCNH2, KCNQ1
delayed rectifier potassium channel activity (GO:0005251) 6.152KCNQ1, KCNH2
identical protein binding (GO:0042802) 2.632GPD1L, KCNH2
protein homodimerization activity (GO:0042803) 3.162GPD1L, KCNH2
sodium channel activity (GO:0005272) 6.132SCN5A, SCN4B
nitric-oxide synthase binding (GO:0050998) 6.912SCN5A, CAV3
ligand-gated channel activity (GO:0022834) 4.82KCNH2, KCNJ8
protein kinase binding (GO:0019901) 3.442KCNQ1, SCN5A
kinase binding (GO:0019900) 3.322KCNQ1, SCN5A
protein domain specific binding (GO:0019904) 3.322KCNH2, SCN5A
small molecule binding (GO:0036094) 1.892GPD1L, KCNJ8
ubiquitin protein ligase binding (GO:0031625) 4.172KCNH2, SCN5A
catalytic activity (GO:0003824) 1.052GPD1L, KCNH2
organic cyclic compound binding (GO:0097159) 1.052GPD1L, KCNJ8
cytoskeletal protein binding (GO:0008092) 3.022SCN5A, CAV3
calmodulin binding (GO:0005516) 4.552KCNQ1, SCN5A
voltage-gated sodium channel activity (GO:0005248) 6.742SCN5A, SCN4B
protein dimerization activity (GO:0046983) 2.722GPD1L, KCNH2
inward rectifier potassium channel activity (GO:0005242) 6.652KCNH2, KCNJ8
transmembrane receptor activity (GO:0099600) 2.532KCNH2, KCNJ8

NET-GE enrichment

Term New enriched termICP valueGenes
potassium channel activity (GO:0005267) -4.940.001KCNQ1, KCNJ8, CAV3, KCNH2
cation channel activity (GO:0005261) -4.040.0SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
ligand-gated ion channel activity (GO:0015276) -4.80.037KCNH2, KCNJ8, CAV3
ion channel binding (GO:0044325) -5.020.0GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
ankyrin binding (GO:0030506) NEW6.740.019SCN5A, CAV3
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) -8.130.0SCN5A, SCN4B
sodium ion transmembrane transporter activity (GO:0015081) -4.830.018SCN5A, SCN4B, CAV3
ATP-activated inward rectifier potassium channel activity (GO:0015272) NEW8.130.0KCNJ8, CAV3
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) -7.790.0KCNH2, KCNQ1
sodium channel regulator activity (GO:0017080) -6.30.0GPD1L, SCN5A, SCN4B, CAV3
transmembrane transporter activity (GO:0022857) -2.820.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
voltage-gated cation channel activity (GO:0022843) -4.830.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) -8.350.0KCNQ1, KCNH2
channel inhibitor activity (GO:0016248) NEW6.130.0KCNH2, SCN5A, CAV3
channel regulator activity (GO:0016247) -4.880.001GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
passive transmembrane transporter activity (GO:0022803) -3.60.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
metal ion transmembrane transporter activity (GO:0046873) -3.710.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
potassium channel regulator activity (GO:0015459) NEW5.930.001KCNH2, KCNQ1, CAV3
sodium channel activity (GO:0005272) -6.130.011SCN5A, SCN4B, CAV3
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
transporter activity (GO:0005215) -2.570.017SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
ion channel activity (GO:0005216) -3.710.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
cation transmembrane transporter activity (GO:0008324) -3.320.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
substrate-specific transporter activity (GO:0022892) -2.720.002SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
delayed rectifier potassium channel activity (GO:0005251) -6.150.009KCNH2, KCNQ1
ion channel inhibitor activity (GO:0008200) NEW6.150.0KCNH2, SCN5A, CAV3
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.002SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
nitric-oxide synthase binding (GO:0050998) -6.910.001SCN5A, CAV3
voltage-gated ion channel activity (GO:0005244) -4.490.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
voltage-gated sodium channel activity (GO:0005248) -6.740.0SCN5A, SCN4B, CAV3
ion transmembrane transporter activity (GO:0015075) -3.040.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
voltage-gated channel activity (GO:0022832) -4.490.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
monovalent inorganic cation transmembrane transporter activity (GO:0015077) -3.870.0SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
channel activity (GO:0015267) -3.60.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
scaffold protein binding (GO:0097110) -5.930.009KCNQ1, SCN5A
gated channel activity (GO:0022836) -3.960.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
voltage-gated potassium channel activity (GO:0005249) -5.240.0KCNQ1, KCNH2, KCNJ8, CAV3
ligand-gated channel activity (GO:0022834) -4.80.037KCNH2, KCNJ8, CAV3
substrate-specific channel activity (GO:0022838) -3.670.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
potassium ion transmembrane transporter activity (GO:0015079) -4.770.0KCNQ1, KCNH2, KCNJ8, CAV3
inward rectifier potassium channel activity (GO:0005242) -6.650.0KCNH2, KCNJ8, CAV3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of biological quality (GO:0065008) 1.687GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of transport (GO:0051049) 2.247GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
biological regulation (GO:0065007) 0.397GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
single-organism process (GO:0044699) 0.487GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
regulation of ion transport (GO:0043269) 3.47GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
regulation of ion transmembrane transport (GO:0034765) 3.777GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
regulation of localization (GO:0032879) 1.947GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
regulation of biological process (GO:0050789) 0.457GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of transmembrane transport (GO:0034762) 3.747GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of membrane potential (GO:0042391) 3.896GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
cardiac muscle cell action potential involved in contraction (GO:0086002) 6.476GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
cardiac muscle cell action potential (GO:0086001) 6.336GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
regulation of system process (GO:0044057) 3.536GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
positive regulation of transport (GO:0051050) 2.96GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
transport (GO:0006810) 1.516SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
regulation of cation transmembrane transport (GO:1904062) 4.46GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
regulation of heart contraction (GO:0008016) 4.356GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
regulation of metal ion transport (GO:0010959) 3.946GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
regulation of heart rate (GO:0002027) 5.296GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
multicellular organismal process (GO:0032501) 1.456SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
single-organism cellular process (GO:0044763) 0.656GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
regulation of multicellular organismal process (GO:0051239) 1.876GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
positive regulation of biological process (GO:0048518) 1.26GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
action potential (GO:0001508) 5.426GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
regulation of blood circulation (GO:1903522) 4.056GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
cellular process (GO:0009987) 0.266GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
establishment of localization (GO:0051234) 1.486SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
localization (GO:0051179) 1.46SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
system process (GO:0003008) 2.36SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
ventricular cardiac muscle cell action potential (GO:0086005) 7.025GPD1L, KCNQ1, SCN5A, CAV3, KCNH2
muscle contraction (GO:0006936) 4.375KCNQ1, SCN5A, SCN4B, CAV3, KCNH2
transmembrane transport (GO:0055085) 2.725KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
cation transport (GO:0006812) 3.115KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
response to stimulus (GO:0050896) 1.225KCNQ1, SCN5A, KCNJ8, CAV3, KCNH2
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) 6.845KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
regulation of membrane repolarization (GO:0060306) 6.45KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
regulation of cellular process (GO:0050794) 0.55GPD1L, KCNH2, SCN5A, CAV3, KCNQ1
positive regulation of ion transport (GO:0043270) 4.365GPD1L, SCN4B, KCNQ1, SCN5A, KCNH2
ion transmembrane transport (GO:0034220) 3.085KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
muscle system process (GO:0003012) 4.185KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
regulation of cardiac muscle cell membrane repolarization (GO:0099623) 6.685KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
metal ion transport (GO:0030001) 3.365KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
inorganic cation transmembrane transport (GO:0098662) 3.555KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
inorganic ion transmembrane transport (GO:0098660) 3.385KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
ion transport (GO:0006811) 2.665KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
cation transmembrane transport (GO:0098655) 3.435KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
monovalent inorganic cation transport (GO:0015672) 3.745KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
developmental process (GO:0032502) 1.364KCNQ1, SCN5A, KCNJ8, CAV3
regulation of ion transmembrane transporter activity (GO:0032412) 4.554GPD1L, KCNQ1, SCN4B, CAV3
striated muscle contraction (GO:0006941) 5.374KCNQ1, SCN4B, SCN5A, KCNH2
signaling (GO:0023052) 3.254KCNQ1, SCN5A, SCN4B, KCNH2
cardiac muscle contraction (GO:0060048) 5.884KCNQ1, SCN4B, SCN5A, KCNH2
multicellular organismal signaling (GO:0035637) 5.364KCNQ1, SCN5A, SCN4B, KCNH2
organic substance metabolic process (GO:0071704) 0.634GPD1L, KCNH2, KCNQ1, CAV3
regulation of transporter activity (GO:0032409) 4.454GPD1L, KCNQ1, SCN4B, CAV3
negative regulation of biological process (GO:0048519) 1.334GPD1L, KCNQ1, KCNH2, CAV3
regulation of molecular function (GO:0065009) 1.784GPD1L, KCNQ1, SCN4B, CAV3
regulation of sodium ion transport (GO:0002028) 5.44GPD1L, SCN5A, SCN4B, CAV3
regulation of sodium ion transmembrane transport (GO:1902305) 5.864GPD1L, SCN5A, SCN4B, CAV3
cardiac conduction (GO:0061337) 5.544KCNQ1, SCN5A, SCN4B, KCNH2
single organism signaling (GO:0044700) 3.254KCNQ1, SCN4B, SCN5A, KCNH2
single-organism developmental process (GO:0044767) 1.494KCNQ1, SCN5A, KCNJ8, CAV3
single-organism transport (GO:0044765) 2.184KCNQ1, KCNH2, KCNJ8, CAV3
metabolic process (GO:0008152) 0.584GPD1L, KCNQ1, KCNH2, CAV3
response to chemical (GO:0042221) 1.984KCNQ1, SCN5A, KCNJ8, KCNH2
single-organism localization (GO:1902578) 2.094KCNQ1, KCNH2, KCNJ8, CAV3
primary metabolic process (GO:0044238) 0.694GPD1L, KCNQ1, KCNH2, CAV3
single-multicellular organism process (GO:0044707) 1.784KCNQ1, SCN5A, SCN4B, KCNH2
regulation of transmembrane transporter activity (GO:0022898) 4.524GPD1L, KCNQ1, SCN4B, CAV3
anatomical structure development (GO:0048856) 1.584KCNQ1, KCNJ8, SCN5A, CAV3
cellular metabolic process (GO:0044237) 0.694GPD1L, KCNH2, KCNQ1, CAV3
regulation of heart rate by cardiac conduction (GO:0086091) 6.334KCNQ1, SCN4B, SCN5A, KCNH2
negative regulation of cellular process (GO:0048523) 1.414GPD1L, KCNH2, KCNQ1, CAV3
positive regulation of cellular process (GO:0048522) 1.34KCNQ1, KCNH2, SCN5A, CAV3
negative regulation of metabolic process (GO:0009892) 1.933GPD1L, KCNQ1, CAV3
regulation of metabolic process (GO:0019222) 1.023GPD1L, KCNQ1, CAV3
regulation of response to stimulus (GO:0048583) 1.543GPD1L, KCNQ1, CAV3
regulation of homeostatic process (GO:0032844) 3.653GPD1L, SCN5A, CAV3
negative regulation of potassium ion transport (GO:0043267) 6.263KCNH2, KCNQ1, CAV3
regulation of potassium ion transport (GO:0043266) 5.313KCNH2, KCNQ1, CAV3
membrane depolarization (GO:0051899) 5.623SCN4B, SCN5A, KCNH2
regulation of striated muscle contraction (GO:0006942) 5.383KCNQ1, SCN5A, CAV3
cellular response to chemical stimulus (GO:0070887) 2.573KCNQ1, SCN5A, KCNH2
negative regulation of ion transmembrane transport (GO:0034766) 5.473KCNQ1, KCNH2, CAV3
negative regulation of transmembrane transport (GO:0034763) 5.383KCNH2, KCNQ1, CAV3
single-organism metabolic process (GO:0044710) 1.633GPD1L, KCNH2, CAV3
negative regulation of macromolecule metabolic process (GO:0010605) 2.013GPD1L, KCNQ1, CAV3
cellular potassium ion transport (GO:0071804) 4.793KCNQ1, KCNJ8, KCNH2
potassium ion transmembrane transport (GO:0071805) 4.793KCNQ1, KCNH2, KCNJ8
regulation of macromolecule metabolic process (GO:0060255) 1.083GPD1L, KCNQ1, CAV3
regulation of sodium ion transmembrane transporter activity (GO:2000649) 6.093GPD1L, SCN4B, CAV3
negative regulation of potassium ion transmembrane transport (GO:1901380) 6.683KCNH2, KCNQ1, CAV3
positive regulation of sodium ion transport (GO:0010765) 6.233GPD1L, SCN5A, SCN4B
negative regulation of transport (GO:0051051) 3.63KCNH2, KCNQ1, CAV3
regulation of muscle contraction (GO:0006937) 4.753KCNQ1, SCN5A, CAV3
potassium ion transport (GO:0006813) 4.683KCNQ1, KCNH2, KCNJ8
cellular response to stimulus (GO:0051716) 1.973KCNQ1, KCNH2, SCN5A
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373) 7.783GPD1L, SCN5A, CAV3
negative regulation of ion transport (GO:0043271) 4.943KCNQ1, KCNH2, CAV3
regulation of potassium ion transmembrane transport (GO:1901379) 5.623KCNQ1, KCNH2, CAV3
regulation of muscle system process (GO:0090257) 4.513KCNQ1, SCN5A, CAV3
membrane depolarization during action potential (GO:0086010) 6.073SCN5A, SCN4B, KCNH2
regulation of cardiac muscle contraction (GO:0055117) 5.573KCNQ1, SCN5A, CAV3
negative regulation of cation transmembrane transport (GO:1904063) 5.653KCNH2, KCNQ1, CAV3
regulation of membrane depolarization (GO:0003254) 6.043GPD1L, SCN5A, CAV3
regulation of ion homeostasis (GO:2000021) 4.443GPD1L, SCN5A, CAV3
regulation of phosphate metabolic process (GO:0019220) 2.352GPD1L, CAV3
regulation of primary metabolic process (GO:0080090) 1.082GPD1L, CAV3
negative regulation of response to stimulus (GO:0048585) 2.522GPD1L, CAV3
cation homeostasis (GO:0055080) 3.462KCNH2, CAV3
inorganic ion homeostasis (GO:0098771) 3.432KCNH2, CAV3
positive regulation of ion transmembrane transport (GO:0034767) 5.052KCNH2, KCNQ1
membrane repolarization during action potential (GO:0086011) 7.432KCNQ1, KCNH2
organic cyclic compound metabolic process (GO:1901360) 1.262GPD1L, KCNQ1
potassium ion export (GO:0071435) 7.432KCNQ1, KCNH2
negative regulation of signal transduction (GO:0009968) 2.752GPD1L, CAV3
regulation of signal transduction (GO:0009966) 1.842GPD1L, CAV3
animal organ development (GO:0048513) 2.532KCNJ8, CAV3
regulation of action potential (GO:0098900) 6.072SCN5A, CAV3
negative regulation of molecular function (GO:0044092) 2.742KCNQ1, CAV3
ion homeostasis (GO:0050801) 3.422KCNH2, CAV3
regulation of cell proliferation (GO:0042127) 2.412SCN5A, CAV3
glycerolipid metabolic process (GO:0046486) 3.912GPD1L, CAV3
response to organic substance (GO:0010033) 2.22KCNQ1, KCNJ8
heterocycle metabolic process (GO:0046483) 1.312GPD1L, KCNQ1
regulation of phosphorylation (GO:0042325) 2.52GPD1L, CAV3
negative regulation of phosphorylation (GO:0042326) 3.72GPD1L, CAV3
response to external stimulus (GO:0009605) 2.552KCNJ8, CAV3
chemical homeostasis (GO:0048878) 2.972KCNH2, CAV3
membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915) 8.342KCNH2, KCNQ1
positive regulation of heart contraction (GO:0045823) 6.152KCNQ1, SCN5A
regulation of protein localization to cell surface (GO:2000008) 6.432GPD1L, CAV3
negative regulation of transporter activity (GO:0032410) 5.592KCNQ1, CAV3
negative regulation of ion transmembrane transporter activity (GO:0032413) 5.742KCNQ1, CAV3
positive regulation of transmembrane transport (GO:0034764) 4.992KCNQ1, KCNH2
nitrogen compound metabolic process (GO:0006807) 1.132GPD1L, KCNQ1
cellular macromolecule metabolic process (GO:0044260) 0.932KCNH2, CAV3
regulation of anatomical structure size (GO:0090066) 3.782KCNJ8, CAV3
lipid metabolic process (GO:0006629) 2.682GPD1L, CAV3
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372) 7.942KCNQ1, SCN5A
sodium ion transport (GO:0006814) 4.752SCN5A, SCN4B
positive regulation of blood circulation (GO:1903524) 5.162KCNQ1, SCN5A
negative regulation of intracellular signal transduction (GO:1902532) 3.632GPD1L, CAV3
regulation of postsynaptic membrane potential (GO:0060078) 5.722SCN5A, SCN4B
regulation of intracellular signal transduction (GO:1902531) 2.312GPD1L, CAV3
potassium ion export across plasma membrane (GO:0097623) 9.042KCNH2, KCNQ1
response to nitrogen compound (GO:1901698) 3.122KCNQ1, KCNJ8
cardiac muscle cell membrane repolarization (GO:0099622) 7.432KCNH2, KCNQ1
ventricular cardiac muscle cell membrane repolarization (GO:0099625) 8.342KCNQ1, KCNH2
acylglycerol metabolic process (GO:0006639) 5.272GPD1L, CAV3
neutral lipid metabolic process (GO:0006638) 5.262GPD1L, CAV3
regulation of cellular protein localization (GO:1903827) 3.432GPD1L, CAV3
negative regulation of signaling (GO:0023057) 2.652GPD1L, CAV3
cellular nitrogen compound metabolic process (GO:0034641) 1.222GPD1L, KCNQ1
negative regulation of cell communication (GO:0010648) 2.662GPD1L, CAV3
regulation of signaling (GO:0023051) 1.722GPD1L, CAV3
regulation of cell communication (GO:0010646) 1.732GPD1L, CAV3
response to organic cyclic compound (GO:0014070) 3.072KCNQ1, KCNJ8
regulation of protein localization (GO:0032880) 2.882GPD1L, CAV3
nucleobase-containing compound metabolic process (GO:0006139) 1.352GPD1L, KCNQ1
negative regulation of protein metabolic process (GO:0051248) 2.822GPD1L, CAV3
positive regulation of multicellular organismal process (GO:0051240) 2.492KCNQ1, SCN5A
negative regulation of phosphorus metabolic process (GO:0010563) 3.452GPD1L, CAV3
regulation of protein metabolic process (GO:0051246) 1.932GPD1L, CAV3
membrane repolarization (GO:0086009) 7.022KCNH2, KCNQ1
regulation of protein modification process (GO:0031399) 2.322GPD1L, CAV3
positive regulation of cell proliferation (GO:0008284) 3.012SCN5A, CAV3
triglyceride metabolic process (GO:0006641) 5.412GPD1L, CAV3
regulation of actin filament-based process (GO:0032970) 3.972SCN5A, CAV3
cellular aromatic compound metabolic process (GO:0006725) 1.32GPD1L, KCNQ1
membrane repolarization during cardiac muscle cell action potential (GO:0086013) 7.432KCNH2, KCNQ1
membrane depolarization during cardiac muscle cell action potential (GO:0086012) 7.092SCN5A, SCN4B
cellular lipid metabolic process (GO:0044255) 2.922GPD1L, CAV3
AV node cell action potential (GO:0086016) 8.342SCN5A, SCN4B
negative regulation of cellular protein metabolic process (GO:0032269) 2.882GPD1L, CAV3
regulation of cellular protein metabolic process (GO:0032268) 1.992GPD1L, CAV3
positive regulation of cation transmembrane transport (GO:1904064) 5.172KCNH2, KCNQ1
response to drug (GO:0042493) 3.712KCNQ1, KCNH2
macromolecule metabolic process (GO:0043170) 0.832KCNH2, CAV3
negative regulation of protein modification process (GO:0031400) 3.42GPD1L, CAV3
regulation of cellular localization (GO:0060341) 3.032GPD1L, CAV3
negative regulation of cellular metabolic process (GO:0031324) 2.012GPD1L, CAV3
regulation of cellular metabolic process (GO:0031323) 1.072GPD1L, CAV3
homeostatic process (GO:0042592) 2.612KCNH2, CAV3
cellular response to drug (GO:0035690) 5.482KCNH2, KCNQ1
positive regulation of potassium ion transport (GO:0043268) 6.092KCNQ1, KCNH2
sodium ion transmembrane transport (GO:0035725) 5.232SCN5A, SCN4B
positive regulation of heart rate (GO:0010460) 6.592KCNQ1, SCN5A
positive regulation of potassium ion transmembrane transport (GO:1901381) 6.432KCNQ1, KCNH2
negative regulation of phosphate metabolic process (GO:0045936) 3.452GPD1L, CAV3
regulation of phosphorus metabolic process (GO:0051174) 2.352GPD1L, CAV3
metal ion homeostasis (GO:0055065) 3.612KCNH2, CAV3
regulation of response to stress (GO:0080134) 2.532KCNQ1, CAV3
response to oxygen-containing compound (GO:1901700) 2.572KCNQ1, KCNJ8
response to abiotic stimulus (GO:0009628) 2.82KCNJ8, CAV3
regulation of potassium ion transmembrane transporter activity (GO:1901016) 6.022KCNQ1, CAV3
negative regulation of potassium ion transmembrane transporter activity (GO:1901017) 6.962KCNQ1, CAV3
phosphate-containing compound metabolic process (GO:0006796) 2.162GPD1L, KCNH2
phosphorus metabolic process (GO:0006793) 2.152GPD1L, KCNH2
negative regulation of protein phosphorylation (GO:0001933) 3.792GPD1L, CAV3
regulation of protein phosphorylation (GO:0001932) 2.572GPD1L, CAV3

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of peptide transport (GO:0090087) NEW4.370.035KCNQ1, KCNJ8, CAV3, KCNH2
regulation of transport (GO:0051049) -2.240.0GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
negative regulation of hormone secretion (GO:0046888) NEW5.410.022KCNQ1, KCNJ8, CAV3
membrane depolarization (GO:0051899) -5.620.002SCN4B, SCN5A, CAV3, KCNH2
positive regulation of transmembrane transport (GO:0034764) -4.990.043KCNQ1, KCNH2
regulation of ion transmembrane transport (GO:0034765) -3.770.0GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
negative regulation of ion transmembrane transport (GO:0034766) -5.470.012KCNH2, CAV3
positive regulation of ion transmembrane transport (GO:0034767) -5.050.034KCNH2, KCNQ1
regulation of transmembrane transport (GO:0034762) -3.740.0GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
negative regulation of transmembrane transport (GO:0034763) -5.380.017KCNH2, CAV3
potassium ion export (GO:0071435) -7.430.003KCNQ1, KCNH2
membrane depolarization during action potential (GO:0086010) -6.070.0SCN5A, SCN4B, KCNH2
regulation of membrane depolarization during action potential (GO:0098902) NEW8.120.005SCN5A, CAV3
regulation of action potential (GO:0098900) -6.070.007SCN5A, CAV3
atrial cardiac muscle cell action potential (GO:0086014) NEW7.650.0KCNQ1, SCN5A, CAV3
regulation of sodium ion transmembrane transport (GO:1902305) -5.860.0GPD1L, SCN5A, SCN4B, CAV3
muscle contraction (GO:0006936) -4.370.001KCNQ1, SCN5A, SCN4B, CAV3, KCNH2
positive regulation of transport (GO:0051050) -2.90.0GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
inorganic ion transmembrane transport (GO:0098660) -3.380.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of peptide hormone secretion (GO:0090276) NEW4.410.032KCNQ1, KCNH2, KCNJ8, CAV3
regulation of potassium ion transmembrane transport (GO:1901379) -5.620.0KCNQ1, KCNH2, CAV3
negative regulation of peptide hormone secretion (GO:0090278) NEW5.880.006KCNQ1, KCNJ8, CAV3
system process (GO:0003008) -2.30.009KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
single organism signaling (GO:0044700) -3.250.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
muscle system process (GO:0003012) -4.180.002KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
positive regulation of potassium ion transmembrane transport (GO:1901381) -6.430.016KCNQ1, KCNH2
regulation of delayed rectifier potassium channel activity (GO:1902259) NEW6.840.005KCNH2, KCNQ1
regulation of protein localization to cell surface (GO:2000008) -6.430.012GPD1L, CAV3
regulation of membrane potential (GO:0042391) -3.890.0GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
regulation of ion transmembrane transporter activity (GO:0032412) -4.550.008GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) -6.840.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
regulation of membrane repolarization (GO:0060306) -6.40.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
action potential (GO:0001508) -5.420.0GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
cardiac muscle cell action potential involved in contraction (GO:0086002) -6.470.0GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
inorganic cation transmembrane transport (GO:0098662) -3.550.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of sodium ion transmembrane transporter activity (GO:2000649) -6.090.0GPD1L, SCN5A, SCN4B, CAV3
regulation of biological quality (GO:0065008) -1.680.001GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
potassium ion transport (GO:0006813) -4.680.012KCNQ1, KCNH2, KCNJ8, CAV3
cation transport (GO:0006812) -3.110.002SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
ion transport (GO:0006811) -2.660.018KCNQ1, KCNJ8, SCN4B, SCN5A, KCNH2
regulation of heart contraction (GO:0008016) -4.350.0GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372) -7.940.001KCNQ1, SCN5A
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373) -7.780.0GPD1L, SCN5A, CAV3
regulation of multicellular organismal process (GO:0051239) -1.870.008GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
cellular potassium ion transport (GO:0071804) -4.790.007KCNQ1, KCNJ8, CAV3, KCNH2
regulation of transmembrane transporter activity (GO:0022898) -4.520.009GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
multicellular organismal signaling (GO:0035637) -5.360.0KCNQ1, SCN5A, SCN4B, CAV3, KCNH2
striated muscle contraction (GO:0006941) -5.370.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
signaling (GO:0023052) -3.250.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
response to purine-containing compound (GO:0014074) NEW4.670.012KCNQ1, KCNJ8, CAV3, KCNH2
cardiac muscle contraction (GO:0060048) -5.880.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
ventricular cardiac muscle cell action potential (GO:0086005) -7.020.0GPD1L, KCNQ1, SCN5A, CAV3, KCNH2
cardiac muscle cell action potential (GO:0086001) -6.330.0GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
regulation of system process (GO:0044057) -3.530.0GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
potassium ion transmembrane transport (GO:0071805) -4.790.007KCNQ1, KCNH2, KCNJ8, CAV3
membrane repolarization (GO:0086009) -7.020.022KCNH2, KCNQ1
regulation of heart rate (GO:0002027) -5.290.0GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, SCN4B
regulation of transporter activity (GO:0032409) -4.450.011GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
monovalent inorganic cation transport (GO:0015672) -3.740.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of sodium ion transport (GO:0002028) -5.40.0GPD1L, SCN5A, SCN4B, CAV3
positive regulation of sodium ion transport (GO:0010765) -6.230.0GPD1L, SCN5A, SCN4B
positive regulation of ion transport (GO:0043270) -4.360.0GPD1L, SCN5A, KCNQ1, SCN4B, KCNH2
metal ion transport (GO:0030001) -3.360.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
membrane repolarization during cardiac muscle cell action potential (GO:0086013) -7.430.002KCNH2, KCNQ1
membrane depolarization during cardiac muscle cell action potential (GO:0086012) -7.090.01SCN5A, SCN4B
membrane repolarization during action potential (GO:0086011) -7.430.011KCNQ1, KCNH2
regulation of localization (GO:0032879) -1.940.0GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
transmembrane transport (GO:0055085) -2.720.013SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
energy derivation by oxidation of organic compounds (GO:0015980) NEW4.930.019KCNQ1, KCNJ8, CAV3, KCNH2
response to drug (GO:0042493) -3.710.022KCNQ1, SCN5A, KCNJ8, CAV3, KCNH2
regulation of membrane depolarization (GO:0003254) -6.040.0GPD1L, SCN5A, CAV3
regulation of heart rate by cardiac conduction (GO:0086091) -6.330.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
negative regulation of potassium ion transport (GO:0043267) -6.260.01KCNH2, CAV3
regulation of potassium ion transport (GO:0043266) -5.310.009KCNH2, KCNQ1, CAV3
potassium ion import (GO:0010107) NEW6.40.0KCNH2, KCNJ8, CAV3
AV node cell to bundle of His cell communication (GO:0086067) NEW8.340.001SCN5A, SCN4B
cell communication involved in cardiac conduction (GO:0086065) NEW6.730.017SCN5A, SCN4B
regulation of ion transport (GO:0043269) -3.40.0GPD1L, SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
positive regulation of potassium ion transport (GO:0043268) -6.090.014KCNQ1, KCNH2
sodium ion transmembrane transport (GO:0035725) -5.230.033SCN5A, SCN4B, CAV3
negative regulation of potassium ion transmembrane transport (GO:1901380) -6.680.001KCNH2, CAV3
response to organophosphorus (GO:0046683) NEW4.790.008KCNQ1, KCNH2, KCNJ8, CAV3
cardiac conduction (GO:0061337) -5.540.0KCNQ1, SCN4B, SCN5A, CAV3, KCNH2
regulation of metal ion transport (GO:0010959) -3.940.0GPD1L, SCN4B, KCNH2, KCNQ1, CAV3, SCN5A
ion transmembrane transport (GO:0034220) -3.080.002SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
single-organism transport (GO:0044765) -2.180.05SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
synaptic transmission (GO:0007268) NEW3.980.015KCNQ1, KCNJ8, SCN5A, CAV3, KCNH2
cell communication (GO:0007154) NEW3.040.043SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
regulation of peptide secretion (GO:0002791) NEW4.380.034KCNQ1, KCNJ8, CAV3, KCNH2
negative regulation of peptide secretion (GO:0002792) NEW5.840.006KCNQ1, KCNJ8, CAV3
regulation of potassium ion transmembrane transporter activity (GO:1901016) -6.020.001KCNQ1, KCNH2, CAV3
regulation of ion homeostasis (GO:2000021) -4.440.012GPD1L, SCN5A, CAV3
cation transmembrane transport (GO:0098655) -3.430.001SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.517GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
cell part (GO:0044464) 0.117GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
membrane (GO:0016020) 0.687GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
macromolecular complex (GO:0032991) 1.357GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
plasma membrane (GO:0005886) 1.397GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
integral component of membrane (GO:0016021) 1.146SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
plasma membrane protein complex (GO:0098797) 3.556SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
membrane protein complex (GO:0098796) 2.846SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
cytoplasmic part (GO:0044444) 0.826GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
intracellular part (GO:0044424) 0.286GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
membrane part (GO:0044425) 0.956SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
plasma membrane part (GO:0044459) 1.956SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
intrinsic component of membrane (GO:0031224) 1.136SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
transmembrane transporter complex (GO:1902495) 4.065KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
transporter complex (GO:1990351) 4.045KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
ion channel complex (GO:0034702) 4.185KCNQ1, SCN4B, SCN5A, KCNJ8, KCNH2
cation channel complex (GO:0034703) 4.695KCNJ8, SCN4B, KCNQ1, SCN5A, KCNH2
membrane-bounded organelle (GO:0043227) 0.475GPD1L, SCN5A, KCNJ8, CAV3, KCNQ1
organelle (GO:0043226) 0.45GPD1L, SCN5A, KCNJ8, CAV3, KCNQ1
intracellular organelle (GO:0043229) 0.514KCNQ1, SCN5A, KCNJ8, CAV3
intracellular membrane-bounded organelle (GO:0043231) 0.64KCNQ1, SCN5A, KCNJ8, CAV3
cytoplasm (GO:0005737) 1.013GPD1L, KCNQ1, CAV3
plasma membrane region (GO:0098590) 2.973KCNQ1, SCN5A, CAV3
membrane raft (GO:0045121) 4.183KCNQ1, SCN5A, CAV3
sarcolemma (GO:0042383) 5.23SCN5A, KCNJ8, CAV3
endoplasmic reticulum (GO:0005783) 2.563KCNQ1, SCN5A, CAV3
cell surface (GO:0009986) 3.443KCNH2, SCN5A, CAV3
membrane region (GO:0098589) 3.953KCNQ1, SCN5A, CAV3
voltage-gated potassium channel complex (GO:0008076) 5.343KCNQ1, KCNH2, KCNJ8
intercalated disc (GO:0014704) 5.933SCN5A, SCN4B, CAV3
potassium channel complex (GO:0034705) 5.323KCNQ1, KCNJ8, KCNH2
organelle part (GO:0044422) 0.793KCNQ1, SCN5A, CAV3
cell-cell junction (GO:0005911) 3.853SCN5A, SCN4B, CAV3
membrane microdomain (GO:0098857) 4.173KCNQ1, SCN5A, CAV3
cell-cell contact zone (GO:0044291) 5.693SCN5A, SCN4B, CAV3
cell junction (GO:0030054) 2.753SCN5A, SCN4B, CAV3
vesicle (GO:0031982) 1.643GPD1L, KCNQ1, CAV3
intracellular organelle part (GO:0044446) 0.812KCNQ1, CAV3
organelle membrane (GO:0031090) 1.972KCNQ1, CAV3
T-tubule (GO:0030315) 6.092SCN5A, CAV3
cytosol (GO:0005829) 1.682GPD1L, CAV3
intracellular (GO:0005622) 2.372KCNH2, SCN5A
sodium channel complex (GO:0034706) 6.972SCN5A, SCN4B
caveola (GO:0005901) 5.552SCN5A, CAV3
plasma membrane raft (GO:0044853) 5.422SCN5A, CAV3
contractile fiber part (GO:0044449) 4.532SCN5A, CAV3
Z disc (GO:0030018) 5.112SCN5A, CAV3
voltage-gated sodium channel complex (GO:0001518) 7.162SCN5A, SCN4B

NET-GE enrichment

Term New enriched termICP valueGenes
myofibril (GO:0030016) NEW6.140.044KCNJ8, CAV3
caveola (GO:0005901) -5.550.016SCN5A, CAV3
potassium channel complex (GO:0034705) -5.320.0KCNQ1, KCNJ8, CAV3, KCNH2
ion channel complex (GO:0034702) -4.180.0SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
cation channel complex (GO:0034703) -4.690.0SCN5A, KCNQ1, KCNH2, CAV3, SCN4B, KCNJ8
synapse (GO:0045202) NEW3.580.014KCNQ1, KCNH2, SCN5A, CAV3
transmembrane transporter complex (GO:1902495) -4.060.0SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
intrinsic component of plasma membrane (GO:0031226) NEW2.530.0SCN5A, SCN4B, CAV3
intrinsic component of membrane (GO:0031224) -1.130.005SCN5A, SCN4B, CAV3
Z disc (GO:0030018) -5.110.0GPD1L, KCNH2, SCN5A, CAV3, KCNQ1
neuron projection (GO:0043005) NEW3.120.038KCNQ1, KCNJ8, SCN5A, CAV3, KCNH2
plasma membrane part (GO:0044459) -1.950.001SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
cell surface (GO:0009986) -3.440.047KCNH2, SCN5A, CAV3
intercalated disc (GO:0014704) -5.930.001SCN5A, SCN4B, CAV3
sarcolemma (GO:0042383) -5.20.0KCNQ1, KCNJ8, SCN5A, CAV3
T-tubule (GO:0030315) -6.090.006SCN5A, CAV3
cell-cell contact zone (GO:0044291) -5.690.008SCN5A, SCN4B, CAV3
transporter complex (GO:1990351) -4.040.0SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
voltage-gated potassium channel complex (GO:0008076) -5.340.0KCNQ1, KCNH2, KCNJ8, CAV3
plasma membrane (GO:0005886) -1.390.033GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
cell projection (GO:0042995) NEW2.470.048GPD1L, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ8
voltage-gated sodium channel complex (GO:0001518) -7.160.002SCN5A, SCN4B
protein complex (GO:0043234) -1.510.002GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
neuromuscular junction (GO:0031594) NEW5.810.002KCNQ1, SCN5A, CAV3
macromolecular complex (GO:0032991) -1.350.005GPD1L, SCN4B, KCNQ1, KCNH2, CAV3, SCN5A, KCNJ8
axolemma (GO:0030673) NEW7.160.009KCNH2, CAV3
neuronal cell body (GO:0043025) NEW3.90.032KCNQ1, KCNH2, SCN5A, CAV3
axon part (GO:0033267) NEW4.40.002SCN5A, KCNJ8, CAV3, KCNH2
sodium channel complex (GO:0034706) -6.970.001SCN5A, SCN4B
contractile fiber part (GO:0044449) -4.530.0GPD1L, KCNH2, SCN5A, CAV3, KCNQ1