Disease table of LONG QT SYNDROME OMIM ID: PS192500

Gene-disease associations table

Gene	Associated with LONG QT SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
KCNE2	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.11	3	PS192500, PS608583, 115000
KCNJ2	ClinVar, OMIM, HUMSAVAR	HGNC link	17q24.3	4	PS609620, PS608583, 115000, PS192500
SNTA1	ClinVar, OMIM, HUMSAVAR	HGNC link	20q11.21	3	PS192500, 603829, 115000
KCNE1	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.12	5	612347, 115000, 613035, 220400, PS192500
CALM2	ClinVar, OMIM	HGNC link	2p21	1	PS192500
KCNJ5	ClinVar, OMIM, HUMSAVAR	HGNC link	11q24.3	3	PS192500, 613677, 115000
KCNH2	ClinVar, OMIM, HUMSAVAR	HGNC link	7q36.1	6	272120, 603829, PS609620, PS604772, 115000, PS192500
CACNA1C	ClinVar, OMIM, HUMSAVAR	HGNC link	12p13.33	4	PS601144, 603829, 115000, PS192500
AKAP9	ClinVar, OMIM, HUMSAVAR	HGNC link	7q21.2	2	PS192500, 115000
KCNQ1	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.5	6	115000, 272120, PS609620, PS608583, PS192500, 220400
SCN5A	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.2	11	272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
ANK2	ClinVar, OMIM, HUMSAVAR	HGNC link	4q25	3	PS192500, PS604772, 115000
ALG10	ClinVar, OMIM	HGNC link	12p11.1	1	PS192500
CALM1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q32.11	2	PS192500, PS604772
SCN4B	ClinVar, OMIM, HUMSAVAR	HGNC link	11q23.3	4	272120, PS608583, 115000, PS192500
CAV3	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.3	7	PS192600, 272120, PS192500, 123320, 614321, PS159000, 606072

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
21q22	2	KCNE1, KCNE2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12p1	2	ALG10, CACNA1C
3p2	2	CAV3, SCN5A
11q2	2	SCN4B, KCNJ5
21q2	2	KCNE1, KCNE2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
21q	2	KCNE1, KCNE2
3p	2	CAV3, SCN5A
12p	2	ALG10, CACNA1C
11q	2	SCN4B, KCNJ5
7q	2	KCNH2, AKAP9

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	KCNQ1, KCNJ5, SCN4B
12	2	ALG10, CACNA1C
21	2	KCNE1, KCNE2
3	2	CAV3, SCN5A
7	2	KCNH2, AKAP9

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
KCNH2	YES	1	SP1	0
CAV3	YES	1	RORA	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
KCNE2	KCNE1	No	1	KCNQ1
KCNE2	AKAP9	No	1	KCNQ1
KCNE2	KCNQ1	Yes	1	ATP4A
SNTA1	CACNA1C	No	1	RYR2
SNTA1	SCN5A	Yes	0
SNTA1	CALM1	No	6	RYR2, SCN5A, HTR2C, UTRN, NEB, SCN4A
SNTA1	CAV3	No	1	SCN5A
KCNE1	CALM2	No	1	ADRB2
KCNE1	KCNJ5	No	1	ADRB2
KCNE1	KCNH2	Yes	0
KCNE1	AKAP9	No	1	KCNQ1
KCNE1	KCNQ1	Yes	0
KCNE1	CALM1	No	1	ADRB2
KCNE1	CAV3	No	2	ADRB2, KCNH2
CALM2	KCNJ5	No	1	ADRB2
CALM2	KCNH2	No	1	CUL1
CALM2	CACNA1C	No	1	CUL1
CALM2	AKAP9	Yes	0
CALM2	KCNQ1	No	2	AKAP9, KCNQ2
CALM2	CALM1	No	17	AKAP9, UNK, ADRB2, CCND2, C11ORF65, LRRK2, CUL4B, SCLT1, VAMP2, PCK1, CUL1, CCP110, CUL3, H2AFX, UBE3A, MCM2, KIAA1683
CALM2	CAV3	No	1	ADRB2
KCNJ5	CALM1	No	2	ADRB2, DRD2
KCNJ5	CAV3	No	1	ADRB2
KCNH2	CACNA1C	No	1	CUL1
KCNH2	KCNQ1	No	3	HSPA4, NEDD4L, KCNE1
KCNH2	SCN5A	No	1	CAV3
KCNH2	ANK2	No	1	NTRK1
KCNH2	CALM1	No	5	HSPA4, FKBP8, YWHAE, CUL1, HSP90AA1
KCNH2	CAV3	Yes	1	NEDD4L
CACNA1C	AKAP9	No	1	CALM1
CACNA1C	SCN5A	No	1	CALM1
CACNA1C	CALM1	Yes	3	TRIM13, RYR2, CUL1
AKAP9	KCNQ1	Yes	2	PRKAR2A, PRKACA
AKAP9	SCN5A	No	1	CALM1
AKAP9	ANK2	No	1	TNIK
AKAP9	CALM1	Yes	9	CCNE1, CDC5L, HUWE1, HERC2, RNF2, MAPRE1, PRKAR2B, PCNT, BMI1
KCNQ1	SCN5A	No	1	NEDD4
KCNQ1	CALM1	No	2	AKAP9, HSPA4
KCNQ1	CAV3	No	1	NEDD4L
SCN5A	CALM1	Yes	0
SCN5A	CAV3	Yes	0
CALM1	CAV3	No	3	ADRB2, SCN5A, EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CALM2	CALM1	Yes	binding	53	PRC1, CAMK1, KLHL22, STRN3, STRN4, KLHL21, CSNK1D, TUBG1, CDK1, MYO5C, CAMK1D, NCOR1, IQGAP1, MYO5B, ADCY8, PAFAH1B1, NCOA3, ZW10, HDAC3, IQCB1, KIF18A, RALA, TBL1X, CALM3, FKBP8, KIF4A, BIRC5, POTEF, PARP4, KNTC1, TBL1XR1, NUMA1, NOS3, TUBGCP3, SKA3, CLASP2, KCNH1, SKA1, IQGAP2, NOS2, STRN, SKA2, KIF18B, CLASP1, CAPN6, POLB, MYO10, DBI, OBSCN, UBC, ARL3, CSNK2A1, CUL3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
CALM2	CALM1	No	-	34	HNRNPR, HIST4H4, HIST1H4B, PABPC1, FKBP8, SSRP1, HIST1H4D, HIST1H4C, HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4, HSPA5, HIST1H4A, HSP90AA1, HIST2H4A, BCL2, HTT, SSB, HIST1H4I, HIST2H4B, TGM2, HIST1H4E, HIST3H2BB, HSP90AB1, SUPT16H, HIST1H4K, NPM1, H2AFX, HIST1H4L, CABIN1, HIST1H4F, CALR, HIST1H4J, HIST1H4H, YWHAQ, EIF3L
AKAP9	KCNQ1	Yes	KCNQ1 macromolecular complex	8	PRKAR2A, PRKAR2B, PPP1CA, PRKACG, PPP1CB, PPP1CC, PRKACA, PRKACB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CALM2	CALM1	No	1	VAMP2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CALM2	CACNA1C	Yes	5	CACNA1C, CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
CALM2	KCNQ1	Yes	5	KCNQ1, CALM3, CALM2, CALM1, CALM1; CALM2; CALM3
CALM2	SCN5A	Yes	5	CALM1, CALM3, CALM2, SCN5A, CALM1; CALM2; CALM3
CALM2	CALM1	Yes	19	CACNA1C, CACNA1S, NOS2, CALM1, GRIN1, CALM1; CALM2; CALM3, FAS, KCNQ3, CALM2, KCNQ1, NOS3, MYLK2, KCNQ4, KCNQ2, SCN2A, SCN5A, SNCA, CALM3, MYLK
CACNA1C	KCNQ1	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
CACNA1C	SCN5A	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
CACNA1C	CALM1	Yes	5	CACNA1C, CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
KCNQ1	SCN5A	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
KCNQ1	CALM1	Yes	5	KCNQ1, CALM3, CALM2, CALM1, CALM1; CALM2; CALM3
SCN5A	CALM1	Yes	5	CALM1, CALM3, CALM2, SCN5A, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
KCNE1	KCNQ1	yes, complex	They are in interaction. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	7	CACNA1C, CALM1, CALM2, KCNQ1, KCNE1, SCN5A, SCN4B
Gastric acid secretion	hsa04971	6.48	5	KCNJ2, CALM1, CALM2, KCNQ1, KCNE2
Oxytocin signaling pathway	hsa04921	5.4	5	KCNJ2, CACNA1C, CALM2, CALM1, KCNJ5
Dopaminergic synapse	hsa04728	5.69	4	CACNA1C, CALM2, CALM1, KCNJ5
Circadian entrainment	hsa04713	6.11	4	CACNA1C, CALM2, CALM1, KCNJ5
cGMP-PKG signaling pathway	hsa04022	5.32	3	CACNA1C, CALM2, CALM1
Calcium signaling pathway	hsa04020	5.22	3	CACNA1C, CALM2, CALM1
cAMP signaling pathway	hsa04024	5.05	3	CACNA1C, CALM2, CALM1
GnRH signaling pathway	hsa04912	6.18	3	CACNA1C, CALM2, CALM1
Long-term potentiation	hsa04720	6.64	3	CACNA1C, CALM2, CALM1
Amphetamine addiction	hsa05031	6.62	3	CACNA1C, CALM2, CALM1
Cholinergic synapse	hsa04725	5.88	3	KCNJ2, CACNA1C, KCNQ1
Estrogen signaling pathway	hsa04915	6.11	3	CALM2, CALM1, KCNJ5
Alzheimer's disease	hsa05010	5.34	3	CACNA1C, CALM2, CALM1
Vascular smooth muscle contraction	hsa04270	5.74	3	CACNA1C, CALM2, CALM1
Pertussis	hsa05133	6.46	2	CALM2, CALM1
Salivary secretion	hsa04970	6.23	2	CALM2, CALM1
Ras signaling pathway	hsa04014	4.9	2	CALM2, CALM1
Proteoglycans in cancer	hsa05205	5.02	2	CAV3, ANK2
Tuberculosis	hsa05152	5.17	2	CALM2, CALM1
Insulin signaling pathway	hsa04910	5.55	2	CALM2, CALM1
Oocyte meiosis	hsa04114	5.91	2	CALM2, CALM1
Phosphatidylinositol signaling system	hsa04070	6.38	2	CALM2, CALM1
Retrograde endocannabinoid signaling	hsa04723	6.03	2	CACNA1C, KCNJ5
Neurotrophin signaling pathway	hsa04722	5.78	2	CALM2, CALM1
Melanogenesis	hsa04916	5.97	2	CALM2, CALM1
Glioma	hsa05214	6.66	2	CALM2, CALM1
Alcoholism	hsa05034	5.59	2	CALM2, CALM1
Serotonergic synapse	hsa04726	5.84	2	CACNA1C, KCNJ5
Olfactory transduction	hsa04740	4.13	2	CALM2, CALM1
Inflammatory mediator regulation of TRP channels	hsa04750	6.07	2	CALM2, CALM1
Phototransduction	hsa04744	7.91	2	CALM2, CALM1
Rap1 signaling pathway	hsa04015	4.97	2	CALM2, CALM1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Gastric acid secretion (hsa04971)	-	6.48	0.001	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, KCNE2
Digestive system	NEW	4.12	0.012	CACNA1C, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2
Calcium signaling pathway (hsa04020)	-	5.22	0.037	CACNA1C, AKAP9, CALM1, CAV3, ANK2
Morphine addiction (hsa05032)	NEW	6.15	0.032	CACNA1C, CALM1, KCNJ5, CAV3
Nervous system	NEW	3.77	0.004	CACNA1C, AKAP9, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, KCNJ5, SNTA1
Insulin secretion (hsa04911)	NEW	6.18	0.034	CACNA1C, CALM1, CAV3, ANK2
Circulatory system	NEW	4.63	0.0	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, CAV3, ANK2, CALM1, SCN4B, SNTA1
Circadian entrainment (hsa04713)	-	6.11	0.045	CACNA1C, AKAP9, CALM1, KCNJ5
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.0	AKAP9, CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, CAV3, ANK2, SCN4B, SNTA1
Oxytocin signaling pathway (hsa04921)	-	5.4	0.01	KCNJ2, CACNA1C, CALM1, KCNJ5

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Neuronal System	R-HSA-112316	4.82	7	AKAP9, CALM1, KCNQ1, CALM2, KCNH2, KCNJ2, KCNJ5
Axon guidance	R-HSA-422475	3.93	7	CACNA1C, AKAP9, SCN5A, CALM1, CALM2, ANK2, SCN4B
Developmental Biology	R-HSA-1266738	3.48	7	CACNA1C, AKAP9, CALM1, CALM2, ANK2, SCN5A, SCN4B
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	5	KCNJ2, AKAP9, CALM2, CALM1, KCNJ5
Transmission across Chemical Synapses	R-HSA-112315	5.28	5	KCNJ2, AKAP9, CALM2, CALM1, KCNJ5
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	4	CACNA1C, AKAP9, CALM2, CALM1
Potassium Channels	R-HSA-1296071	6.35	4	KCNJ2, KCNH2, KCNQ1, KCNJ5
CREB phosphorylation through the activation of CaMKII	R-HSA-442729	9.08	3	AKAP9, CALM2, CALM1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	AKAP9, CALM2, CALM1
Immune System	R-HSA-168256	2.37	3	AKAP9, CALM2, CALM1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	AKAP9, CALM2, CALM1
Signaling by Interleukins	R-HSA-449147	4.71	3	AKAP9, CALM2, CALM1
Muscle contraction	R-HSA-397014	6.96	3	CALM2, CALM1, CAV3
Post NMDA receptor activation events	R-HSA-438064	7.85	3	AKAP9, CALM2, CALM1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	AKAP9, CALM2, CALM1
Frs2-mediated activation	R-HSA-170968	5.12	3	AKAP9, CALM2, CALM1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	AKAP9, CALM2, CALM1
IGF1R signaling cascade	R-HSA-2428924	4.85	3	AKAP9, CALM2, CALM1
Downstream signal transduction	R-HSA-186763	4.65	3	AKAP9, CALM2, CALM1
Ras activation uopn Ca2+ infux through NMDA receptor	R-HSA-442982	8.89	3	AKAP9, CALM2, CALM1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	AKAP9, CALM2, CALM1
Signaling by ERBB4	R-HSA-1236394	4.7	3	AKAP9, CALM2, CALM1
Signaling by Insulin receptor	R-HSA-74752	4.73	3	AKAP9, CALM2, CALM1
CREB phosphorylation through the activation of Ras	R-HSA-442742	8.23	3	AKAP9, CALM2, CALM1
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	AKAP9, CALM2, CALM1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	AKAP9, CALM2, CALM1
MAPK family signaling cascades	R-HSA-5683057	4.89	3	AKAP9, CALM2, CALM1
Signaling by Leptin	R-HSA-2586552	5.1	3	AKAP9, CALM2, CALM1
Signaling by VEGF	R-HSA-194138	4.66	3	AKAP9, CALM2, CALM1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	AKAP9, CALM2, CALM1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	AKAP9, CALM2, CALM1
IRS-mediated signalling	R-HSA-112399	4.87	3	AKAP9, CALM2, CALM1
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	AKAP9, CALM2, CALM1
SOS-mediated signalling	R-HSA-112412	5.15	3	AKAP9, CALM2, CALM1
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	AKAP9, CALM2, CALM1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	AKAP9, CALM2, CALM1
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	AKAP9, CALM2, CALM1
Signaling by FGFR4	R-HSA-5654743	4.69	3	AKAP9, CALM2, CALM1
Signaling by FGFR3	R-HSA-5654741	4.69	3	AKAP9, CALM2, CALM1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	AKAP9, CALM2, CALM1
Interaction between L1 and Ankyrins	R-HSA-445095	8.03	3	SCN5A, SCN4B, ANK2
L1CAM interactions	R-HSA-373760	6.19	3	SCN5A, SCN4B, ANK2
Signaling by FGFR	R-HSA-190236	4.67	3	AKAP9, CALM2, CALM1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	AKAP9, CALM2, CALM1
Interleukin-2 signaling	R-HSA-451927	5.05	3	AKAP9, CALM2, CALM1
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	AKAP9, CALM2, CALM1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	AKAP9, CALM2, CALM1
Innate Immune System	R-HSA-168249	3.17	3	AKAP9, CALM2, CALM1
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	AKAP9, CALM2, CALM1
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	AKAP9, CALM2, CALM1
Signalling to ERKs	R-HSA-187687	5.04	3	AKAP9, CALM2, CALM1
Signaling by PDGF	R-HSA-186797	4.53	3	AKAP9, CALM2, CALM1
Signalling to RAS	R-HSA-167044	5.08	3	AKAP9, CALM2, CALM1
DAP12 signaling	R-HSA-2424491	4.64	3	AKAP9, CALM2, CALM1
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	AKAP9, CALM2, CALM1
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	AKAP9, CALM2, CALM1
Activation of NMDA receptor upon glutamate binding and postsynaptic events	R-HSA-442755	7.7	3	AKAP9, CALM2, CALM1
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	AKAP9, CALM2, CALM1
Signaling by FGFR1	R-HSA-5654736	4.69	3	AKAP9, CALM2, CALM1
Signaling by EGFR	R-HSA-177929	4.59	3	AKAP9, CALM2, CALM1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	AKAP9, CALM2, CALM1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	AKAP9, CALM2, CALM1
Prolonged ERK activation events	R-HSA-169893	5.11	3	AKAP9, CALM2, CALM1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	AKAP9, CALM2, CALM1
Signalling by NGF	R-HSA-166520	4.23	3	AKAP9, CALM2, CALM1
Signaling by GPCR	R-HSA-372790	2.68	3	AKAP9, CALM2, CALM1
Signaling by FGFR2	R-HSA-5654738	4.68	3	AKAP9, CALM2, CALM1
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	AKAP9, CALM2, CALM1
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	AKAP9, CALM2, CALM1
ARMS-mediated activation	R-HSA-170984	5.12	3	AKAP9, CALM2, CALM1
DAP12 interactions	R-HSA-2172127	4.56	3	AKAP9, CALM2, CALM1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	AKAP9, CALM2, CALM1
Signaling by ERBB2	R-HSA-1227986	4.66	3	AKAP9, CALM2, CALM1
Metabolism	R-HSA-1430728	2.34	3	CACNA1C, CALM2, CALM1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	AKAP9, CALM2, CALM1
Signal Transduction	R-HSA-162582	1.78	3	AKAP9, CALM2, CALM1
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	7.37	2	CALM2, CALM1
Inwardly rectifying K+ channels	R-HSA-1296065	8.03	2	KCNJ2, KCNJ5
Activation of G protein gated Potassium channels	R-HSA-1296041	8.34	2	KCNJ2, KCNJ5
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85	2	CALM2, CALM1
Visual phototransduction	R-HSA-2187338	6.44	2	CALM2, CALM1
Platelet degranulation	R-HSA-114608	6.68	2	CALM2, CALM1
Ca-dependent events	R-HSA-111996	8.18	2	CALM2, CALM1
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.46	2	CALM2, CALM1
PLC-gamma1 signalling	R-HSA-167021	7.89	2	CALM2, CALM1
eNOS activation	R-HSA-203615	9.98	2	CALM2, CALM1
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	2	CALM2, CALM1
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.89	2	CALM2, CALM1
Activation of CaMK IV	R-HSA-442745	11.98	2	CALM2, CALM1
Adaptive Immune System	R-HSA-1280218	3.19	2	CALM2, CALM1
DAG and IP3 signaling	R-HSA-1489509	7.98	2	CALM2, CALM1
Calmodulin induced events	R-HSA-111933	8.28	2	CALM2, CALM1
CaMK IV-mediated phosphorylation of CREB	R-HSA-111932	11.4	2	CALM2, CALM1
Cam-PDE 1 activation	R-HSA-111957	10.98	2	CALM2, CALM1
DARPP-32 events	R-HSA-180024	8.4	2	CALM2, CALM1
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.52	2	CALM2, CALM1
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.43	2	CALM2, CALM1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	CALM2, CALM1
Glucose metabolism	R-HSA-70326	6.77	2	CALM2, CALM1
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	2	CALM2, CALM1
Metabolism of nitric oxide	R-HSA-202131	8.81	2	CALM2, CALM1
GABA receptor activation	R-HSA-977443	7.2	2	KCNJ2, KCNJ5
Ca2+ pathway	R-HSA-4086398	7.1	2	CALM2, CALM1
The phototransduction cascade	R-HSA-2514856	8.03	2	CALM2, CALM1
G protein gated Potassium channels	R-HSA-1296059	8.34	2	KCNJ2, KCNJ5
GABA B receptor activation	R-HSA-977444	7.7	2	KCNJ2, KCNJ5
RHO GTPases activate PAKs	R-HSA-5627123	8.59	2	CALM2, CALM1
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.08	2	CALM2, CALM1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.34	2	KCNJ2, KCNJ5
Inositol phosphate metabolism	R-HSA-1483249	7.52	2	CALM2, CALM1
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	CALM2, CALM1
Voltage gated Potassium channels	R-HSA-1296072	7.56	2	KCNH2, KCNQ1
FCERI mediated Ca+2 mobilization	R-HSA-2871809	5.45	2	CALM2, CALM1
beta-catenin independent WNT signaling	R-HSA-3858494	5.83	2	CALM2, CALM1
eNOS activation and regulation	R-HSA-203765	8.81	2	CALM2, CALM1
Signaling by Rho GTPases	R-HSA-194315	4.43	2	CALM2, CALM1
Membrane Trafficking	R-HSA-199991	5.26	2	CALM2, CALM1
CLEC7A (Dectin-1) induces NFAT activation	R-HSA-5607763	9.52	2	CALM2, CALM1
Translocation of GLUT4 to the plasma membrane	R-HSA-1445148	6.77	2	CALM2, CALM1
CREB phosphorylation through the activation of CaMKK	R-HSA-442717	10.98	2	CALM2, CALM1
Activation of Ca-permeable Kainate Receptor	R-HSA-451308	9.66	2	CALM2, CALM1
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	R-HSA-1474151	9.66	2	CALM2, CALM1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	CALM2, CALM1
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	R-HSA-983695	5.6	2	CALM2, CALM1
RHO GTPase Effectors	R-HSA-195258	4.94	2	CALM2, CALM1
Signaling by Wnt	R-HSA-195721	4.79	2	CALM2, CALM1
PLC beta mediated events	R-HSA-112043	7.52	2	CALM2, CALM1
G-protein mediated events	R-HSA-112040	7.49	2	CALM2, CALM1
Metabolism of carbohydrates	R-HSA-71387	4.93	2	CALM2, CALM1
Opioid Signalling	R-HSA-111885	6.64	2	CALM2, CALM1
Activation of Kainate Receptors upon glutamate binding	R-HSA-451326	8.08	2	CALM2, CALM1
Ionotropic activity of Kainate Receptors	R-HSA-451306	9.66	2	CALM2, CALM1
Synthesis of IP3 and IP4 in the cytosol	R-HSA-1855204	8.34	2	CALM2, CALM1
CaM pathway	R-HSA-111997	8.28	2	CALM2, CALM1
Activation of GABAB receptors	R-HSA-991365	7.7	2	KCNJ2, KCNJ5
RHO GTPases activate IQGAPs	R-HSA-5626467	8.34	2	CALM2, CALM1
Glycogen breakdown (glycogenolysis)	R-HSA-70221	9.08	2	CALM2, CALM1
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.38	2	CALM2, CALM1
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28	2	CALM2, CALM1
Smooth Muscle Contraction	R-HSA-445355	8.23	2	CALM2, CALM1
Hemostasis	R-HSA-109582	3.98	2	CALM2, CALM1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
CREB phosphorylation through the activation of CaMKII (R-HSA-442729)	-	9.08	0.048	AKAP9, CALM1
Inwardly rectifying K+ channels (R-HSA-1296065)	-	8.03	0.0	KCNJ2, CACNA1C, CAV3, ANK2, KCNJ5
Activation of G protein gated Potassium channels (R-HSA-1296041)	-	8.34	0.004	KCNJ2, CACNA1C, KCNJ5
Sodium/Calcium exchangers (R-HSA-425561)	NEW	9.81	0.048	CALM1, CAV3
Ras activation uopn Ca2+ infux through NMDA receptor (R-HSA-442982)	-	8.89	0.044	AKAP9, CALM1
Developmental Biology (R-HSA-1266738)	-	3.48	0.048	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, SCN4B
GABA receptor activation (R-HSA-977443)	-	7.2	0.0	KCNJ2, CACNA1C, CALM1, KCNJ5, CAV3
G protein gated Potassium channels (R-HSA-1296059)	-	8.34	0.004	KCNJ2, CACNA1C, KCNJ5
GABA B receptor activation (R-HSA-977444)	-	7.7	0.0	KCNJ2, CACNA1C, CALM1, KCNJ5, CAV3
Neuronal System (R-HSA-112316)	-	4.82	0.0	CACNA1C, AKAP9, CALM1, ANK2, KCNQ1, KCNH2, CAV3, KCNJ2, KCNJ5, SNTA1
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (R-HSA-112314)	-	5.85	0.006	CACNA1C, AKAP9, CALM1, CAV3, KCNJ2, KCNJ5
Transmission across Chemical Synapses (R-HSA-112315)	-	5.28	0.029	CACNA1C, AKAP9, CALM1, CAV3, KCNJ2, KCNJ5, SNTA1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (R-HSA-997272)	-	8.34	0.004	KCNJ2, CACNA1C, KCNJ5
L1CAM interactions (R-HSA-373760)	-	6.19	0.03	CALM1, SCN4B, SCN5A, ANK2
Potassium Channels (R-HSA-1296071)	-	6.35	0.002	CACNA1C, CALM1, KCNJ5, KCNH2, KCNQ1, CAV3, KCNJ2, ANK2
Interaction between L1 and Ankyrins (R-HSA-445095)	-	8.03	0.0	CALM1, SCN5A, SCN4B, ANK2
Integration of energy metabolism (R-HSA-163685)	NEW	6.24	0.0	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
Activation of GABAB receptors (R-HSA-991365)	-	7.7	0.0	KCNJ2, CACNA1C, CALM1, KCNJ5, CAV3
Regulation of insulin secretion (R-HSA-422356)	NEW	6.66	0.0	CACNA1C, KCNQ1, CALM1, CAV3, ANK2
Stimuli-sensing channels (R-HSA-2672351)	NEW	6.28	0.026	CACNA1C, AKAP9, CALM1, CAV3
Axon guidance (R-HSA-422475)	-	3.93	0.012	CACNA1C, AKAP9, CALM1, CAV3, ANK2, SCN5A, SNTA1, SCN4B
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676)	NEW	7.59	0.022	CACNA1C, CALM1, KCNQ1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	15	CACNA1C, AKAP9, KCNE1, ANK2, KCNQ1, CALM2, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SCN5A, SNTA1, SCN4B
protein binding (GO:0005515)	0.46	14	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, KCNJ5, SCN4B
substrate-specific transporter activity (GO:0022892)	2.72	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, KCNJ5, SCN4B
transporter activity (GO:0005215)	2.57	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
ion channel activity (GO:0005216)	3.71	10	CACNA1C, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, KCNE1, SCN4B
ion transmembrane transporter activity (GO:0015075)	3.04	10	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, SCN5A, SCN4B
transmembrane transporter activity (GO:0022857)	2.82	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
channel activity (GO:0015267)	3.6	10	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, SCN5A, SCN4B
gated channel activity (GO:0022836)	3.96	10	CACNA1C, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, KCNE1, SCN4B
passive transmembrane transporter activity (GO:0022803)	3.6	10	CACNA1C, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, KCNE1
substrate-specific channel activity (GO:0022838)	3.67	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	9	CACNA1C, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN4B
cation channel activity (GO:0005261)	4.04	9	CACNA1C, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNE1
cation transmembrane transporter activity (GO:0008324)	3.32	9	CACNA1C, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN4B
voltage-gated channel activity (GO:0022832)	4.49	9	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN5A, SCN4B
ion channel binding (GO:0044325)	5.02	9	AKAP9, SCN5A, CALM1, KCNQ1, KCNE2, CAV3, ANK2, SCN4B, SNTA1
voltage-gated ion channel activity (GO:0005244)	4.49	9	CACNA1C, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
metal ion transmembrane transporter activity (GO:0046873)	3.71	9	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN5A, SCN4B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	8	SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN4B
molecular function regulator (GO:0098772)	2.51	7	AKAP9, CALM1, KCNE1, KCNE2, CAV3, SCN4B, SNTA1
voltage-gated cation channel activity (GO:0022843)	4.83	7	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
enzyme binding (GO:0019899)	2.27	7	CALM1, KCNH2, KCNQ1, CAV3, ANK2, SCN5A, SNTA1
cytoskeletal protein binding (GO:0008092)	3.02	7	CACNA1C, CALM1, KCNE1, CAV3, ANK2, SCN5A, SNTA1
channel regulator activity (GO:0016247)	4.88	6	AKAP9, SCN4B, CAV3, KCNE2, KCNE1, SNTA1
potassium channel activity (GO:0005267)	4.94	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
potassium ion transmembrane transporter activity (GO:0015079)	4.77	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
voltage-gated potassium channel activity (GO:0005249)	5.24	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008)	7.79	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
ligand-gated ion channel activity (GO:0015276)	4.8	5	KCNJ2, KCNH2, CALM1, KCNJ5, KCNE2
molecular transducer activity (GO:0060089)	2.32	5	KCNJ2, CALM1, KCNH2, KCNJ5, KCNE2
receptor activity (GO:0004872)	2.32	5	KCNJ2, KCNH2, CALM1, KCNJ5, KCNE2
ligand-gated channel activity (GO:0022834)	4.8	5	KCNJ2, CALM1, KCNH2, KCNJ5, KCNE2
transmembrane receptor activity (GO:0099600)	2.53	5	KCNJ2, KCNH2, CALM1, KCNJ5, KCNE2
nitric-oxide synthase binding (GO:0050998)	6.91	4	CALM1, SNTA1, SCN5A, CAV3
catalytic activity (GO:0003824)	1.05	4	AKAP9, CALM1, KCNH2, ALG10
potassium channel regulator activity (GO:0015459)	5.93	4	AKAP9, KCNE1, CAV3, KCNE2
structural molecule activity (GO:0005198)	3.1	4	AKAP9, SNTA1, CAV3, ANK2
protein kinase binding (GO:0019901)	3.44	4	CALM1, KCNQ1, SCN5A, ANK2
kinase binding (GO:0019900)	3.32	4	CALM1, KCNQ1, SCN5A, ANK2
transferase activity (GO:0016740)	1.95	4	AKAP9, KCNH2, CALM1, ALG10
calmodulin binding (GO:0005516)	4.55	4	CACNA1C, KCNQ1, SNTA1, SCN5A
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282)	8.35	4	KCNQ1, KCNH2, KCNE1, KCNE2
delayed rectifier potassium channel activity (GO:0005251)	6.15	4	KCNQ1, KCNE1, KCNE2, KCNH2
inward rectifier potassium channel activity (GO:0005242)	6.65	4	KCNJ2, KCNH2, KCNJ5, KCNE2
protein domain specific binding (GO:0019904)	3.32	4	CALM1, KCNH2, SNTA1, SCN5A
cation binding (GO:0043169)	1.4	3	CACNA1C, CALM2, CALM1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	AKAP9, CALM1, KCNH2
kinase activity (GO:0016301)	2.93	3	AKAP9, CALM1, KCNH2
ion binding (GO:0043167)	1.36	3	CACNA1C, CALM2, CALM1
sodium channel regulator activity (GO:0017080)	6.3	3	SNTA1, SCN4B, CAV3
scaffold protein binding (GO:0097110)	5.93	3	KCNQ1, KCNH2, SCN5A
metal ion binding (GO:0046872)	1.41	3	CACNA1C, CALM2, CALM1
identical protein binding (GO:0042802)	2.63	3	KCNJ2, KCNH2, KCNE2
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	AKAP9, CALM1
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	KCNH2, SCN5A
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	AKAP9, CALM1
G-protein activated inward rectifier potassium channel activity (GO:0015467)	7.44	2	KCNJ2, KCNJ5
protein complex scaffold (GO:0032947)	5.5	2	AKAP9, CAV3
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030)	6.74	2	SCN5A, SCN4B
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	8.13	2	SCN5A, SCN4B
sodium ion transmembrane transporter activity (GO:0015081)	4.83	2	SCN5A, SCN4B
phospholipid binding (GO:0005543)	3.91	2	KCNJ2, KCNQ1
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	5.81	2	KCNJ2, KCNQ1
phosphatidylinositol bisphosphate binding (GO:1902936)	5.79	2	KCNJ2, KCNQ1
calcium ion binding (GO:0005509)	3.17	2	CALM2, CALM1
protein homodimerization activity (GO:0042803)	3.16	2	KCNH2, KCNE2
protein kinase A binding (GO:0051018)	6.02	2	AKAP9, KCNQ1
sodium channel activity (GO:0005272)	6.13	2	SCN5A, SCN4B
ATPase binding (GO:0051117)	5.41	2	SNTA1, ANK2
lipid binding (GO:0008289)	3.26	2	KCNJ2, KCNQ1
phosphatidylinositol phosphate binding (GO:1901981)	5.05	2	KCNJ2, KCNQ1
protein dimerization activity (GO:0046983)	2.72	2	KCNH2, KCNE2
ubiquitin protein ligase binding (GO:0031625)	4.17	2	KCNH2, SCN5A
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	CALM1, KCNH2
phosphatidylinositol binding (GO:0035091)	4.47	2	KCNJ2, KCNQ1
voltage-gated sodium channel activity (GO:0005248)	6.74	2	SCN5A, SCN4B
receptor binding (GO:0005102)	2.43	2	AKAP9, CALM1
protein kinase A regulatory subunit binding (GO:0034237)	6.97	2	AKAP9, KCNQ1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
potassium channel activity (GO:0005267)	-	4.94	0.0	CACNA1C, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5
cation channel activity (GO:0005261)	-	4.04	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
enzyme binding (GO:0019899)	-	2.27	0.008	CALM1, KCNH2, KCNQ1, CAV3, ANK2, SCN5A, SNTA1
ligand-gated ion channel activity (GO:0015276)	-	4.8	0.034	AKAP9, CALM1, ANK2, KCNH2, CAV3, KCNJ2, KCNJ5
ion channel binding (GO:0044325)	-	5.02	0.0	CACNA1C, AKAP9, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, CALM1, SNTA1
substrate-specific channel activity (GO:0022838)	-	3.67	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
ankyrin binding (GO:0030506)	NEW	6.74	0.0	CALM1, SCN5A, CAV3, ANK2
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	-	8.13	0.002	SCN5A, SCN4B
calcium-release channel activity (GO:0015278)	NEW	6.97	0.0	CACNA1C, CALM1, CAV3
sodium ion transmembrane transporter activity (GO:0015081)	-	4.83	0.001	CALM1, SCN5A, SCN4B, CAV3, ANK2
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008)	-	7.79	0.0	KCNJ2, KCNQ1, KCNH2, KCNE2
sodium channel regulator activity (GO:0017080)	-	6.3	0.026	CALM1, SCN4B, SCN5A, CAV3
transmembrane transporter activity (GO:0022857)	-	2.82	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
voltage-gated cation channel activity (GO:0022843)	-	4.83	0.0	CACNA1C, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282)	-	8.35	0.0	KCNH2, KCNQ1, KCNE2
transporter activity (GO:0005215)	-	2.57	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
channel regulator activity (GO:0016247)	-	4.88	0.0	SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, CAV3, ANK2, SCN4B
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.0	CACNA1C, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
ion channel activity (GO:0005216)	-	3.71	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
calmodulin binding (GO:0005516)	-	4.55	0.001	CACNA1C, SCN5A, KCNQ1, CAV3, ANK2, CALM1, SNTA1
intracellular ligand-gated ion channel activity (GO:0005217)	NEW	6.41	0.002	CACNA1C, CALM1, CAV3
sodium channel activity (GO:0005272)	-	6.13	0.007	SCN5A, SCN4B, CAV3
voltage-gated potassium channel activity (GO:0005249)	-	5.24	0.0	CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5
nitric-oxide synthase binding (GO:0050998)	-	6.91	0.0	CALM1, SNTA1, SCN5A, CAV3
ATPase binding (GO:0051117)	-	5.41	0.001	CALM1, SNTA1, SCN5A, ANK2
potassium channel regulator activity (GO:0015459)	-	5.93	0.0	KCNE1, KCNH2, KCNQ1, CAV3, KCNE2, ANK2
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
G-protein coupled glutamate receptor binding (GO:0035256)	NEW	7.95	0.005	CACNA1C, CALM1
PDZ domain binding (GO:0030165)	NEW	5.22	0.029	CALM1, SNTA1, SCN5A, CAV3
channel inhibitor activity (GO:0016248)	NEW	6.13	0.011	KCNH2, SCN5A, CAV3
delayed rectifier potassium channel activity (GO:0005251)	-	6.15	0.041	KCNQ1, KCNH2
ion channel inhibitor activity (GO:0008200)	NEW	6.15	0.011	KCNH2, SCN5A, CAV3
substrate-specific transmembrane transporter activity (GO:0022891)	-	2.9	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.0	CACNA1C, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
substrate-specific transporter activity (GO:0022892)	-	2.72	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
cytoskeletal protein binding (GO:0008092)	-	3.02	0.0	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1, SNTA1
alkali metal ion binding (GO:0031420)	NEW	6.69	0.001	CALM1, CAV3, ANK2
voltage-gated sodium channel activity (GO:0005248)	-	6.74	0.017	SCN5A, SCN4B, CAV3
ion transmembrane transporter activity (GO:0015075)	-	3.04	0.0	AKAP9, CACNA1C, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
voltage-gated channel activity (GO:0022832)	-	4.49	0.0	CACNA1C, AKAP9, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN5A, SNTA1, SCN4B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.0	SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1
channel activity (GO:0015267)	-	3.6	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
gated channel activity (GO:0022836)	-	3.96	0.0	AKAP9, CACNA1C, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
protein binding (GO:0005515)	-	0.46	0.034	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
ligand-gated channel activity (GO:0022834)	-	4.8	0.034	AKAP9, CALM1, ANK2, KCNH2, CAV3, KCNJ2, KCNJ5
calcium (GO:0015368)	NEW	7.44	0.038	CALM1, CAV3
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
potassium ion transmembrane transporter activity (GO:0015079)	-	4.77	0.0	CACNA1C, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5
inward rectifier potassium channel activity (GO:0005242)	-	6.65	0.0	CALM1, KCNJ5, KCNH2, CAV3, KCNJ2, ANK2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
regulation of transport (GO:0051049)	2.24	14	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
biological regulation (GO:0065007)	0.39	14	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
single-organism process (GO:0044699)	0.48	14	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SCN4B
regulation of ion transport (GO:0043269)	3.4	14	CACNA1C, AKAP9, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SCN4B, SNTA1
regulation of ion transmembrane transport (GO:0034765)	3.77	14	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
regulation of localization (GO:0032879)	1.94	14	CACNA1C, AKAP9, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1
regulation of biological process (GO:0050789)	0.45	14	CACNA1C, AKAP9, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SCN4B, SNTA1
regulation of transmembrane transport (GO:0034762)	3.74	14	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
multicellular organismal process (GO:0032501)	1.45	13	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SCN4B, SNTA1
regulation of biological quality (GO:0065008)	1.68	13	CACNA1C, AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, KCNE1, SNTA1, SCN4B
regulation of system process (GO:0044057)	3.53	13	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SCN4B, SNTA1
transport (GO:0006810)	1.51	13	CALM1, AKAP9, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, CACNA1C
regulation of cation transmembrane transport (GO:1904062)	4.4	13	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SCN4B, SNTA1
regulation of heart contraction (GO:0008016)	4.35	13	AKAP9, CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of metal ion transport (GO:0010959)	3.94	13	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of heart rate (GO:0002027)	5.29	13	AKAP9, CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
single-organism cellular process (GO:0044763)	0.65	13	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
regulation of multicellular organismal process (GO:0051239)	1.87	13	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SCN4B, SNTA1
regulation of blood circulation (GO:1903522)	4.05	13	CALM1, AKAP9, SCN5A, SCN4B, KCNQ1, KCNH2, CACNA1C, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
cellular process (GO:0009987)	0.26	13	CACNA1C, AKAP9, SCN5A, KCNE1, ANK2, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1
establishment of localization (GO:0051234)	1.48	13	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B
localization (GO:0051179)	1.4	13	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SCN4B
regulation of membrane potential (GO:0042391)	3.89	12	CACNA1C, AKAP9, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
regulation of cellular process (GO:0050794)	0.5	12	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SNTA1
cardiac muscle cell action potential (GO:0086001)	6.33	11	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
cardiac muscle cell action potential involved in contraction (GO:0086002)	6.47	11	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
positive regulation of transport (GO:0051050)	2.9	11	AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SCN4B
ion transport (GO:0006811)	2.66	11	CACNA1C, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, KCNE1
regulation of membrane repolarization (GO:0060306)	6.4	11	AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
positive regulation of biological process (GO:0048518)	1.2	11	AKAP9, SCN5A, CALM1, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN4B
action potential (GO:0001508)	5.42	11	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
single organism signaling (GO:0044700)	3.25	10	CACNA1C, AKAP9, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, ANK2, KCNE1, SCN4B
cardiac conduction (GO:0061337)	5.54	10	CACNA1C, AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, SCN5A, SCN4B
single-multicellular organism process (GO:0044707)	1.78	10	CACNA1C, AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, SCN5A, SCN4B
cation transport (GO:0006812)	3.11	10	CACNA1C, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN5A, SCN4B
response to stimulus (GO:0050896)	1.22	10	AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	6.84	10	AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of heart rate by cardiac conduction (GO:0086091)	6.33	10	CACNA1C, AKAP9, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1
positive regulation of ion transport (GO:0043270)	4.36	10	AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, CALM1, SCN4B
ion transmembrane transport (GO:0034220)	3.08	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
single-organism transport (GO:0044765)	2.18	10	CACNA1C, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
regulation of cardiac muscle cell membrane repolarization (GO:0099623)	6.68	10	AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
signaling (GO:0023052)	3.25	10	CACNA1C, AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1, SCN4B
metal ion transport (GO:0030001)	3.36	10	CACNA1C, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN4B
multicellular organismal signaling (GO:0035637)	5.36	10	CACNA1C, AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1, SCN4B
transmembrane transport (GO:0055085)	2.72	10	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
single-organism localization (GO:1902578)	2.09	10	CACNA1C, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
positive regulation of cellular process (GO:0048522)	1.3	10	AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1
cation transmembrane transport (GO:0098655)	3.43	9	CACNA1C, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNE1
inorganic ion transmembrane transport (GO:0098660)	3.38	9	CACNA1C, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN5A, SCN4B
inorganic cation transmembrane transport (GO:0098662)	3.55	9	CACNA1C, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
system process (GO:0003008)	2.3	9	SCN5A, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, KCNE1, SNTA1, SCN4B
ventricular cardiac muscle cell action potential (GO:0086005)	7.02	8	KCNE1, KCNH2, KCNQ1, KCNE2, CAV3, ANK2, SCN5A, SNTA1
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	8	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, KCNE1, SCN4B
regulation of transmembrane transporter activity (GO:0022898)	4.52	8	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, KCNE1, SCN4B
positive regulation of cation transmembrane transport (GO:1904064)	5.17	8	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1
regulation of transporter activity (GO:0032409)	4.45	8	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, KCNE1, SCN4B
regulation of potassium ion transport (GO:0043266)	5.31	8	AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2
muscle system process (GO:0003012)	4.18	8	CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, SCN5A, SNTA1, SCN4B
regulation of potassium ion transmembrane transport (GO:1901379)	5.62	8	AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2
positive regulation of transmembrane transport (GO:0034764)	4.99	8	AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, CALM1
response to chemical (GO:0042221)	1.98	8	AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, ANK2, KCNE1
regulation of molecular function (GO:0065009)	1.78	8	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, KCNE1, SCN4B
positive regulation of ion transmembrane transport (GO:0034767)	5.05	8	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1
monovalent inorganic cation transport (GO:0015672)	3.74	8	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, SCN5A, SCN4B
developmental process (GO:0032502)	1.36	7	CACNA1C, SCN5A, KCNQ1, KCNE2, CAV3, ANK2, CALM1
primary metabolic process (GO:0044238)	0.69	7	AKAP9, CALM1, ALG10, KCNQ1, KCNH2, CAV3, KCNE1
cellular response to stimulus (GO:0051716)	1.97	7	AKAP9, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, SCN5A
muscle contraction (GO:0006936)	4.37	7	SCN5A, CALM1, KCNQ1, KCNH2, CAV3, SCN4B, SNTA1
regulation of metabolic process (GO:0019222)	1.02	7	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, SNTA1
regulation of muscle contraction (GO:0006937)	4.75	7	CACNA1C, SCN5A, KCNQ1, CAV3, KCNJ2, ANK2, CALM1
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	AKAP9, CALM1, KCNQ1, KCNE2, CAV3, ANK2, SNTA1
anatomical structure development (GO:0048856)	1.58	7	CACNA1C, SCN5A, KCNQ1, KCNE2, CAV3, ANK2, CALM1
cellular metabolic process (GO:0044237)	0.69	7	AKAP9, CALM1, ALG10, KCNH2, KCNQ1, CAV3, KCNE1
single-organism developmental process (GO:0044767)	1.49	7	CACNA1C, SCN5A, KCNQ1, KCNE2, CAV3, ANK2, CALM1
organic substance metabolic process (GO:0071704)	0.63	7	AKAP9, CALM1, ALG10, KCNH2, KCNQ1, CAV3, KCNE1
regulation of striated muscle contraction (GO:0006942)	5.38	7	CACNA1C, SCN5A, KCNQ1, CAV3, KCNJ2, ANK2, CALM1
regulation of muscle system process (GO:0090257)	4.51	7	CACNA1C, SCN5A, KCNQ1, CAV3, KCNJ2, ANK2, CALM1
metabolic process (GO:0008152)	0.58	7	AKAP9, CALM1, ALG10, KCNH2, KCNQ1, CAV3, KCNE1
negative regulation of biological process (GO:0048519)	1.33	7	CALM1, KCNQ1, KCNH2, KCNE2, CAV3, KCNE1, SNTA1
regulation of cardiac muscle contraction (GO:0055117)	5.57	7	CACNA1C, SCN5A, KCNQ1, CAV3, KCNJ2, ANK2, CALM1
negative regulation of cellular process (GO:0048523)	1.41	7	CALM1, KCNH2, KCNQ1, KCNE2, CAV3, KCNE1, SNTA1
single-organism metabolic process (GO:0044710)	1.63	6	AKAP9, CALM1, ALG10, KCNH2, CAV3, KCNE1
membrane depolarization during action potential (GO:0086010)	6.07	6	CACNA1C, SCN5A, KCNH2, KCNJ2, ANK2, SCN4B
cellular macromolecule metabolic process (GO:0044260)	0.93	6	AKAP9, CALM1, ALG10, KCNH2, CAV3, KCNE1
cellular potassium ion transport (GO:0071804)	4.79	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
potassium ion transmembrane transport (GO:0071805)	4.79	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
potassium ion transport (GO:0006813)	4.68	6	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5
negative regulation of transport (GO:0051051)	3.6	6	CALM1, KCNH2, KCNQ1, CAV3, KCNE2, KCNE1
negative regulation of cation transmembrane transport (GO:1904063)	5.65	6	CALM1, KCNH2, KCNQ1, CAV3, KCNE2, KCNE1
regulation of potassium ion transmembrane transporter activity (GO:1901016)	6.02	6	AKAP9, KCNE1, KCNQ1, CAV3, KCNE2, ANK2
macromolecule metabolic process (GO:0043170)	0.83	6	AKAP9, CALM1, ALG10, KCNH2, CAV3, KCNE1
negative regulation of ion transport (GO:0043271)	4.94	6	CALM1, KCNH2, KCNQ1, CAV3, KCNE2, KCNE1
membrane depolarization (GO:0051899)	5.62	6	CACNA1C, SCN4B, KCNH2, KCNJ2, ANK2, SCN5A
cellular response to chemical stimulus (GO:0070887)	2.57	6	AKAP9, SCN5A, KCNQ1, KCNH2, KCNE2, KCNE1
negative regulation of ion transmembrane transport (GO:0034766)	5.47	6	CALM1, KCNQ1, KCNH2, CAV3, KCNE2, KCNE1
negative regulation of transmembrane transport (GO:0034763)	5.38	6	CALM1, KCNH2, KCNQ1, CAV3, KCNE2, KCNE1
positive regulation of potassium ion transmembrane transport (GO:1901381)	6.43	6	AKAP9, KCNE1, KCNQ1, KCNH2, KCNJ2, ANK2
positive regulation of potassium ion transport (GO:0043268)	6.09	6	AKAP9, KCNE1, KCNQ1, KCNH2, KCNJ2, ANK2
negative regulation of transporter activity (GO:0032410)	5.59	5	CALM1, KCNQ1, KCNE1, CAV3, KCNE2
positive regulation of metabolic process (GO:0009893)	1.74	5	AKAP9, CAV3, CALM1, ANK2, KCNE2
regulation of cellular localization (GO:0060341)	3.03	5	CACNA1C, CALM1, KCNE1, CAV3, ANK2
negative regulation of ion transmembrane transporter activity (GO:0032413)	5.74	5	KCNQ1, CALM1, KCNE1, CAV3, KCNE2
ion homeostasis (GO:0050801)	3.42	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
regulation of cellular metabolic process (GO:0031323)	1.07	5	AKAP9, SNTA1, CALM1, CAV3, KCNE2
regulation of homeostatic process (GO:0032844)	3.65	5	CACNA1C, CALM1, SCN5A, CAV3, ANK2
homeostatic process (GO:0042592)	2.61	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
membrane repolarization during cardiac muscle cell action potential (GO:0086013)	7.43	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
signal transduction (GO:0007165)	1.28	5	CACNA1C, AKAP9, KCNH2, ANK2, CALM1
regulation of signaling (GO:0023051)	1.72	5	CACNA1C, CAV3, CALM1, ANK2, KCNE2
inorganic ion homeostasis (GO:0098771)	3.43	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
intracellular signal transduction (GO:0035556)	2.39	5	CACNA1C, AKAP9, KCNH2, ANK2, CALM1
regulation of cell communication (GO:0010646)	1.73	5	CACNA1C, CAV3, CALM1, ANK2, KCNE2
regulation of primary metabolic process (GO:0080090)	1.08	5	AKAP9, SNTA1, CALM1, CAV3, KCNE2
cellular protein metabolic process (GO:0044267)	1.63	5	AKAP9, KCNE1, CALM1, ALG10, KCNH2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	AKAP9, CAV3, CALM1, ANK2, KCNE2
regulation of protein metabolic process (GO:0051246)	1.93	5	AKAP9, SNTA1, CALM1, CAV3, KCNE2
membrane repolarization (GO:0086009)	7.02	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
regulation of action potential (GO:0098900)	6.07	5	KCNJ2, CACNA1C, SCN5A, CAV3, ANK2
negative regulation of molecular function (GO:0044092)	2.74	5	CALM1, KCNQ1, KCNE1, CAV3, KCNE2
negative regulation of potassium ion transmembrane transport (GO:1901380)	6.68	5	KCNQ1, KCNH2, KCNE1, CAV3, KCNE2
regulation of actin filament-based process (GO:0032970)	3.97	5	KCNJ2, CACNA1C, SCN5A, CAV3, ANK2
cellular protein modification process (GO:0006464)	1.79	5	AKAP9, KCNE1, CALM1, ALG10, KCNH2
macromolecule modification (GO:0043412)	1.73	5	AKAP9, KCNE1, CALM1, ALG10, KCNH2
protein modification process (GO:0036211)	1.79	5	AKAP9, KCNE1, CALM1, ALG10, KCNH2
metal ion homeostasis (GO:0055065)	3.61	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
cation homeostasis (GO:0055080)	3.46	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	7.09	5	CACNA1C, SCN4B, SCN5A, KCNJ2, ANK2
membrane repolarization during action potential (GO:0086011)	7.43	5	KCNJ2, KCNH2, KCNE1, KCNE2, KCNQ1
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	5	CACNA1C, CAV3, CALM1, ANK2, KCNE2
response to organic substance (GO:0010033)	2.2	5	AKAP9, KCNQ1, KCNE1, ANK2, CALM1
negative regulation of potassium ion transport (GO:0043267)	6.26	5	KCNQ1, KCNE1, CAV3, KCNE2, KCNH2
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	AKAP9, SNTA1, CALM1, CAV3, KCNE2
protein metabolic process (GO:0019538)	1.45	5	AKAP9, KCNE1, CALM1, ALG10, KCNH2
regulation of calcium ion transport (GO:0051924)	4.38	5	CACNA1C, CAV3, CALM1, ANK2, KCNE2
chemical homeostasis (GO:0048878)	2.97	5	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
cardiac muscle cell membrane repolarization (GO:0099622)	7.43	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
regulation of ion homeostasis (GO:2000021)	4.44	5	CACNA1C, CALM1, SCN5A, CAV3, ANK2
regulation of cation channel activity (GO:2001257)	5.27	5	KCNQ1, KCNE1, CALM1, ANK2, KCNE2
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	4	AKAP9, CALM1, ANK2, KCNE2
cellular homeostasis (GO:0019725)	3.23	4	KCNJ2, CACNA1C, CAV3, ANK2
negative regulation of metabolic process (GO:0009892)	1.93	4	CALM1, SNTA1, KCNQ1, CAV3
positive regulation of transporter activity (GO:0032411)	5.44	4	AKAP9, CALM1, ANK2, KCNE2
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	AKAP9, CALM1, CAV3, KCNE2
regulation of response to stimulus (GO:0048583)	1.54	4	KCNQ1, CALM1, CAV3, KCNE2
striated muscle contraction (GO:0006941)	5.37	4	KCNQ1, KCNH2, SCN5A, SCN4B
cardiac muscle contraction (GO:0060048)	5.88	4	KCNQ1, KCNH2, SCN5A, SCN4B
cellular component organization or biogenesis (GO:0071840)	1.22	4	KCNJ2, AKAP9, CAV3, ANK2
response to endogenous stimulus (GO:0009719)	2.79	4	AKAP9, CALM1, KCNE1, KCNQ1
potassium ion export (GO:0071435)	7.43	4	KCNQ1, KCNH2, KCNE1, KCNE2
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	CALM1, SNTA1, KCNQ1, CAV3
positive regulation of protein metabolic process (GO:0051247)	2.43	4	AKAP9, CALM1, CAV3, KCNE2
cellular component organization (GO:0016043)	1.24	4	KCNJ2, AKAP9, CAV3, ANK2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	AKAP9, CALM1, CAV3, KCNE2
response to organic cyclic compound (GO:0014070)	3.07	4	AKAP9, CALM1, KCNE1, KCNQ1
positive regulation of molecular function (GO:0044093)	2.23	4	AKAP9, CALM1, ANK2, KCNE2
regulation of protein modification process (GO:0031399)	2.32	4	AKAP9, SNTA1, CALM1, CAV3
regulation of sodium ion transport (GO:0002028)	5.4	4	SCN5A, SNTA1, SCN4B, CAV3
regulation of sodium ion transmembrane transport (GO:1902305)	5.86	4	SCN5A, SNTA1, SCN4B, CAV3
regulation of cardiac muscle cell contraction (GO:0086004)	6.51	4	CACNA1C, KCNJ2, SCN5A, ANK2
regulation of actin filament-based movement (GO:1903115)	6.33	4	KCNJ2, CACNA1C, SCN5A, ANK2
cellular metal ion homeostasis (GO:0006875)	3.75	4	KCNJ2, CACNA1C, CAV3, ANK2
cellular ion homeostasis (GO:0006873)	3.57	4	KCNJ2, CACNA1C, CAV3, ANK2
cellular cation homeostasis (GO:0030003)	3.6	4	KCNJ2, CACNA1C, CAV3, ANK2
cell communication (GO:0007154)	3.04	4	CACNA1C, AKAP9, SCN5A, ANK2
cellular chemical homeostasis (GO:0055082)	3.4	4	KCNJ2, CACNA1C, CAV3, ANK2
regulation of calcium ion import (GO:0090279)	5.08	4	CACNA1C, CALM1, CAV3, ANK2
response to oxygen-containing compound (GO:1901700)	2.57	4	AKAP9, KCNQ1, KCNE1, CALM1
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	4	CAV3, CALM1, ANK2, KCNE2
regulation of cellular component movement (GO:0051270)	3.08	4	KCNJ2, CACNA1C, SCN5A, ANK2
response to organonitrogen compound (GO:0010243)	3.2	4	AKAP9, CALM1, KCNE1, KCNQ1
negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.96	4	KCNQ1, KCNE1, CAV3, KCNE2
membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915)	8.34	4	KCNQ1, KCNE1, KCNE2, KCNH2
ventricular cardiac muscle cell membrane repolarization (GO:0099625)	8.34	4	KCNQ1, KCNH2, KCNE1, KCNE2
negative regulation of cation channel activity (GO:2001258)	6.26	4	CALM1, KCNQ1, KCNE1, KCNE2
response to nitrogen compound (GO:1901698)	3.12	4	AKAP9, KCNE1, CALM1, KCNQ1
cellular response to cAMP (GO:0071320)	5.82	3	AKAP9, KCNQ1, KCNE1
regulation of phosphate metabolic process (GO:0019220)	2.35	3	AKAP9, CALM1, CAV3
phosphorylation (GO:0016310)	2.63	3	AKAP9, KCNH2, CALM1
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	SNTA1, CALM1, CAV3
regulation of sequestering of calcium ion (GO:0051282)	5.07	3	CACNA1C, CALM1, ANK2
cellular response to drug (GO:0035690)	5.48	3	KCNH2, KCNQ1, KCNE2
calcium ion homeostasis (GO:0055074)	3.97	3	CACNA1C, CAV3, ANK2
second-messenger-mediated signaling (GO:0019932)	4.65	3	CACNA1C, CALM1, ANK2
potassium ion import (GO:0010107)	6.4	3	KCNJ2, KCNJ5, KCNE2
response to purine-containing compound (GO:0014074)	4.67	3	AKAP9, KCNQ1, KCNE1
cell communication involved in cardiac conduction (GO:0086065)	6.73	3	CACNA1C, SCN5A, ANK2
carbohydrate metabolic process (GO:0005975)	3.26	3	CALM1, KCNE1, ALG10
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	AKAP9, KCNH2, CALM1
regulation of protein localization (GO:0032880)	2.88	3	CACNA1C, KCNE1, CAV3
divalent inorganic cation homeostasis (GO:0072507)	3.9	3	CACNA1C, CAV3, ANK2
negative regulation of protein metabolic process (GO:0051248)	2.82	3	SNTA1, CALM1, CAV3
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	3	CACNA1C, CAV3, ANK2
regulation of signal transduction (GO:0009966)	1.84	3	CALM1, CAV3, KCNE2
divalent metal ion transport (GO:0070838)	4.15	3	KCNJ2, CACNA1C, ANK2
positive regulation of protein modification process (GO:0031401)	2.7	3	AKAP9, CALM1, CAV3
cellular response to organic substance (GO:0071310)	2.78	3	AKAP9, KCNQ1, KCNE1
animal organ development (GO:0048513)	2.53	3	CACNA1C, CAV3, KCNE2
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	6.36	3	CALM1, ANK2, KCNE2
regulation of cardiac muscle cell action potential (GO:0098901)	6.78	3	CACNA1C, CAV3, ANK2
positive regulation of calcium ion transmembrane transport (GO:1904427)	5.69	3	CALM1, ANK2, KCNE2
regulation of receptor activity (GO:0010469)	4.98	3	CALM1, CAV3, KCNE2
response to organophosphorus (GO:0046683)	4.79	3	AKAP9, KCNQ1, KCNE1
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	3	CACNA1C, CALM1, ANK2
cellular response to endogenous stimulus (GO:0071495)	3.33	3	AKAP9, KCNQ1, KCNE1
protein phosphorylation (GO:0006468)	2.89	3	AKAP9, KCNH2, CALM1
cellular component assembly (GO:0022607)	2.14	3	KCNJ2, CAV3, ANK2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	6.9	3	CACNA1C, CALM1, ANK2
negative regulation of delayed rectifier potassium channel activity (GO:1902260)	7.53	3	KCNQ1, KCNE1, KCNE2
calcium-mediated signaling (GO:0019722)	5.24	3	CACNA1C, CALM1, ANK2
cellular calcium ion homeostasis (GO:0006874)	4.01	3	CACNA1C, CAV3, ANK2
regulation of catalytic activity (GO:0050790)	1.97	3	AKAP9, CALM1, CAV3
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	AKAP9, CALM1, CAV3
response to cAMP (GO:0051591)	5.08	3	AKAP9, KCNQ1, KCNE1
single-organism carbohydrate metabolic process (GO:0044723)	3.42	3	CALM1, KCNE1, ALG10
negative regulation of voltage-gated potassium channel activity (GO:1903817)	7.53	3	KCNQ1, KCNE1, KCNE2
regulation of phosphorylation (GO:0042325)	2.5	3	AKAP9, CALM1, CAV3
cellular response to oxygen-containing compound (GO:1901701)	3.22	3	AKAP9, KCNQ1, KCNE1
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	3	SNTA1, CALM1, CAV3
regulation of protein phosphorylation (GO:0001932)	2.57	3	AKAP9, CALM1, CAV3
divalent inorganic cation transport (GO:0072511)	4.13	3	KCNJ2, CACNA1C, ANK2
vesicle-mediated transport (GO:0016192)	2.72	3	CALM1, CAV3, ANK2
positive regulation of calcium ion transport (GO:0051928)	5.06	3	CALM1, ANK2, KCNE2
cellular response to organic cyclic compound (GO:0071407)	3.93	3	AKAP9, KCNQ1, KCNE1
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	5.44	3	CACNA1C, CALM1, ANK2
cellular response to nitrogen compound (GO:1901699)	3.79	3	AKAP9, KCNQ1, KCNE1
response to drug (GO:0042493)	3.71	3	KCNQ1, KCNH2, KCNE2
cellular response to organonitrogen compound (GO:0071417)	3.87	3	AKAP9, KCNQ1, KCNE1
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	AKAP9, KCNH2, CALM1
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	6.68	3	CACNA1C, CALM1, ANK2
regulation of delayed rectifier potassium channel activity (GO:1902259)	6.84	3	KCNQ1, KCNE1, KCNE2
phosphorus metabolic process (GO:0006793)	2.15	3	AKAP9, KCNH2, CALM1
system development (GO:0048731)	2.92	3	CACNA1C, KCNQ1, ANK2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.59	3	CACNA1C, CALM1, ANK2
negative regulation of protein modification process (GO:0031400)	3.4	3	SNTA1, CALM1, CAV3
positive regulation of cation channel activity (GO:2001259)	6.17	3	CALM1, ANK2, KCNE2
protein localization (GO:0008104)	2.36	2	CAV3, ANK2
regulation of secretion (GO:0051046)	3.2	2	CACNA1C, KCNQ1
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	2	AKAP9, CALM1
negative regulation of response to stimulus (GO:0048585)	2.52	2	CALM1, CAV3
membrane organization (GO:0061024)	3.04	2	CAV3, ANK2
plasma membrane organization (GO:0007009)	4.8	2	CAV3, ANK2
potassium ion homeostasis (GO:0055075)	6.84	2	KCNJ2, KCNH2
membrane depolarization during AV node cell action potential (GO:0086045)	8.34	2	CACNA1C, SCN5A
membrane depolarization during SA node cell action potential (GO:0086046)	8.34	2	SCN5A, ANK2
establishment of protein localization to plasma membrane (GO:0090002)	5.2	2	CAV3, ANK2
protein localization to plasma membrane (GO:0072659)	5.29	2	CAV3, ANK2
regulation of cardiac conduction (GO:1903779)	5.57	2	CALM1, ANK2
negative regulation of signal transduction (GO:0009968)	2.75	2	CALM1, CAV3
cellular macromolecule localization (GO:0070727)	3.1	2	CAV3, ANK2
MAPK cascade (GO:0000165)	3.91	2	AKAP9, CALM1
response to mechanical stimulus (GO:0009612)	4.41	2	KCNJ2, CAV3
macromolecule localization (GO:0033036)	2.34	2	CAV3, ANK2
regulation of cell proliferation (GO:0042127)	2.41	2	SCN5A, CAV3
sensory perception of sound (GO:0007605)	4.82	2	KCNQ1, KCNE1
regulation of protein kinase activity (GO:0045859)	3.15	2	CALM1, CAV3
sensory perception (GO:0007600)	2.93	2	KCNQ1, KCNE1
establishment of protein localization (GO:0045184)	2.53	2	CAV3, ANK2
regulation of proteolysis (GO:0030162)	3.2	2	CAV3, KCNE2
protein localization to membrane (GO:0072657)	3.95	2	CAV3, ANK2
response to metal ion (GO:0010038)	3.91	2	CALM1, SCN5A
response to inorganic substance (GO:0010035)	3.56	2	CALM1, SCN5A
positive regulation of phosphorylation (GO:0042327)	2.9	2	AKAP9, CALM1
negative regulation of phosphorylation (GO:0042326)	3.7	2	CALM1, CAV3
response to external stimulus (GO:0009605)	2.55	2	KCNJ2, CAV3
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	CACNA1C, CAV3
positive regulation of heart contraction (GO:0045823)	6.15	2	KCNQ1, SCN5A
positive regulation of catabolic process (GO:0009896)	3.94	2	CAV3, KCNE2
regulation of catabolic process (GO:0009894)	3.52	2	CAV3, KCNE2
microtubule cytoskeleton organization (GO:0000226)	4.13	2	AKAP9, CAV3
regulation of protein transport (GO:0051223)	3.12	2	CACNA1C, KCNE1
regulation of oxidoreductase activity (GO:0051341)	5.27	2	CALM1, CAV3
protein localization to cell periphery (GO:1990778)	4.91	2	CAV3, ANK2
positive regulation of GTPase activity (GO:0043547)	3.28	2	AKAP9, CALM1
positive regulation of hydrolase activity (GO:0051345)	2.91	2	AKAP9, CALM1
regulation of kinase activity (GO:0043549)	3.07	2	CALM1, CAV3
regulation of immune system process (GO:0002682)	2.5	2	KCNQ1, CALM1
regulation of sodium ion transmembrane transporter activity (GO:2000649)	6.09	2	SCN4B, CAV3
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	CAV3, ANK2
regulation of establishment of protein localization (GO:0070201)	3.02	2	CACNA1C, KCNE1
lipid metabolic process (GO:0006629)	2.68	2	CAV3, ALG10
sensory perception of mechanical stimulus (GO:0050954)	4.79	2	KCNQ1, KCNE1
regulation of monooxygenase activity (GO:0032768)	5.69	2	CALM1, CAV3
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372)	7.94	2	KCNQ1, SCN5A
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)	7.78	2	SCN5A, CAV3
sodium ion transport (GO:0006814)	4.75	2	SCN5A, SCN4B
positive regulation of blood circulation (GO:1903524)	5.16	2	KCNQ1, SCN5A
macromolecule glycosylation (GO:0043413)	4.2	2	KCNE1, ALG10
single-organism membrane organization (GO:0044802)	3.19	2	CAV3, ANK2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	CALM1, CAV3
regulation of postsynaptic membrane potential (GO:0060078)	5.72	2	SCN5A, SCN4B
regulation of intracellular signal transduction (GO:1902531)	2.31	2	CALM1, CAV3
neurological system process (GO:0050877)	2.64	2	KCNQ1, KCNE1
regulation of hydrolase activity (GO:0051336)	2.53	2	AKAP9, CALM1
potassium ion export across plasma membrane (GO:0097623)	9.04	2	KCNH2, KCNQ1
detection of stimulus (GO:0051606)	3.22	2	CALM1, CAV3
sensory organ development (GO:0007423)	4.82	2	CACNA1C, KCNE2
regulation of response to stress (GO:0080134)	2.53	2	KCNQ1, CAV3
regulation of transferase activity (GO:0051338)	2.88	2	CALM1, CAV3
positive regulation of protein catabolic process (GO:0045732)	4.18	2	CAV3, KCNE2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	AKAP9, CALM1
regulation of response to external stimulus (GO:0032101)	3.06	2	CALM1, KCNQ1
negative regulation of cellular component organization (GO:0051129)	3.35	2	KCNE1, CAV3
regulation of cellular component organization (GO:0051128)	2.01	2	KCNE1, CAV3
regulation of cellular protein localization (GO:1903827)	3.43	2	KCNE1, CAV3
negative regulation of signaling (GO:0023057)	2.65	2	CALM1, CAV3
regulation of protein catabolic process (GO:0042176)	3.83	2	CAV3, KCNE2
negative regulation of cell communication (GO:0010648)	2.66	2	CALM1, CAV3
response to calcium ion (GO:0051592)	4.98	2	CALM1, SCN5A
anatomical structure morphogenesis (GO:0009653)	2.53	2	CACNA1C, SCN5A
regulation of GTPase activity (GO:0043087)	3.21	2	AKAP9, CALM1
positive regulation of catalytic activity (GO:0043085)	2.4	2	AKAP9, CALM1
negative regulation of cellular protein localization (GO:1903828)	4.82	2	KCNE1, CAV3
regulation of cellular catabolic process (GO:0031329)	3.83	2	CAV3, KCNE2
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	KCNQ1, SCN5A
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	CALM1, CAV3
positive regulation of sodium ion transport (GO:0010765)	6.23	2	SCN5A, SCN4B
positive regulation of cell proliferation (GO:0008284)	3.01	2	SCN5A, CAV3
organelle organization (GO:0006996)	2.02	2	AKAP9, CAV3
positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	6.96	2	AKAP9, ANK2
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	2	CAV3, KCNE2
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	CAV3, KCNE2
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	2	CAV3, KCNE2
cellular lipid metabolic process (GO:0044255)	2.92	2	CAV3, ALG10
T-tubule organization (GO:0033292)	8.63	2	CAV3, ANK2
AV node cell action potential (GO:0086016)	8.34	2	SCN5A, SCN4B
SA node cell action potential (GO:0086015)	7.94	2	SCN5A, ANK2
atrial cardiac muscle cell action potential (GO:0086014)	7.65	2	KCNQ1, ANK2
regulation of membrane depolarization (GO:0003254)	6.04	2	SCN5A, CAV3
calcium ion transport (GO:0006816)	4.33	2	CACNA1C, ANK2
establishment of protein localization to membrane (GO:0090150)	4.14	2	CAV3, ANK2
positive regulation of proteolysis (GO:0045862)	3.86	2	CAV3, KCNE2
cell cycle G2/M phase transition (GO:0044839)	4.82	2	AKAP9, CALM1
mitotic cell cycle process (GO:1903047)	3.12	2	AKAP9, CALM1
cell cycle phase transition (GO:0044770)	4.24	2	AKAP9, CALM1
mitotic cell cycle phase transition (GO:0044772)	4.27	2	AKAP9, CALM1
cell cycle process (GO:0022402)	2.75	2	AKAP9, CALM1
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	CALM1, CAV3
protein glycosylation (GO:0006486)	4.2	2	KCNE1, ALG10
sodium ion transmembrane transport (GO:0035725)	5.23	2	SCN5A, SCN4B
positive regulation of heart rate (GO:0010460)	6.59	2	KCNQ1, SCN5A
regulation of cellular protein catabolic process (GO:1903362)	4.23	2	CAV3, KCNE2
regulation of voltage-gated calcium channel activity (GO:1901385)	6.59	2	CALM1, KCNE2
regulation of gene expression (GO:0010468)	1.37	2	KCNQ1, ANK2
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	2	CAV3, KCNE2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	AKAP9, CALM1
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	CALM1, CAV3
cellular protein localization (GO:0034613)	3.11	2	CAV3, ANK2
glycosylation (GO:0070085)	4.16	2	KCNE1, ALG10
monovalent inorganic cation homeostasis (GO:0055067)	4.93	2	KCNJ2, KCNH2
establishment of localization in cell (GO:0051649)	2.47	2	CACNA1C, ANK2
cellular localization (GO:0051641)	2.32	2	CAV3, ANK2
regulation of nitric-oxide synthase activity (GO:0050999)	5.9	2	CALM1, CAV3
response to abiotic stimulus (GO:0009628)	2.8	2	KCNJ2, CAV3
microtubule-based process (GO:0007017)	3.54	2	AKAP9, CAV3
cytoskeleton organization (GO:0007010)	3.22	2	AKAP9, CAV3
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	CACNA1C, CAV3
negative regulation of calcium ion transport (GO:0051926)	5.84	2	CALM1, CAV3
single-organism organelle organization (GO:1902589)	2.68	2	AKAP9, CAV3
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	CALM1, CAV3
single-organism cellular localization (GO:1902580)	3.16	2	CAV3, ANK2
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	AKAP9, CALM1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of peptide transport (GO:0090087)	NEW	4.37	0.012	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
protein localization (GO:0008104)	-	2.36	0.012	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, SCN5A
protein homotetramerization (GO:0051289)	NEW	5.63	0.009	KCNJ2, CACNA1C, SNTA1, CALM1
regulation of transport (GO:0051049)	-	2.24	0.0	CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
regulation of sequestering of calcium ion (GO:0051282)	-	5.07	0.041	CACNA1C, CALM1, CAV3
negative regulation of sequestering of calcium ion (GO:0051283)	NEW	6.04	0.034	CACNA1C, CALM1, CAV3
regulation of homeostatic process (GO:0032844)	-	3.65	0.003	CACNA1C, CALM1, SCN5A, CAV3, ANK2
membrane repolarization during cardiac muscle cell action potential (GO:0086013)	-	7.43	0.0	KCNJ2, KCNQ1, KCNE1, KCNH2
membrane depolarization (GO:0051899)	-	5.62	0.0	CACNA1C, SCN5A, KCNH2, CAV3, KCNJ2, ANK2, CALM1, SNTA1, SCN4B
potassium ion homeostasis (GO:0055075)	-	6.84	0.004	KCNJ2, CALM1, KCNH2
negative regulation of peptidyl-cysteine S-nitrosylation (GO:1902083)	NEW	8.63	0.008	SNTA1, CALM1
membrane depolarization during SA node cell action potential (GO:0086046)	-	8.34	0.002	SCN5A, ANK2
action potential (GO:0001508)	-	5.42	0.0	CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
negative regulation of ion transmembrane transport (GO:0034766)	-	5.47	0.007	CALM1, KCNH2, CAV3
positive regulation of ion transmembrane transport (GO:0034767)	-	5.05	0.0	KCNJ2, CALM1, KCNE1, KCNH2, KCNQ1
regulation of transmembrane transport (GO:0034762)	-	3.74	0.0	CALM1, AKAP9, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, CACNA1C, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
negative regulation of transmembrane transport (GO:0034763)	-	5.38	0.025	KCNH2, CALM1, CAV3
potassium ion export (GO:0071435)	-	7.43	0.0	KCNQ1, KCNH2, KCNE1, KCNE2
regulation of localization (GO:0032879)	-	1.94	0.0	CACNA1C, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1
cellular macromolecule localization (GO:0070727)	-	3.1	0.023	CALM1, KCNH2, KCNQ1, KCNE2, CAV3, ANK2, SCN5A
release of sequestered calcium ion into cytosol (GO:0051209)	NEW	6.04	0.034	CACNA1C, CALM1, CAV3
calcium-mediated signaling using extracellular calcium source (GO:0035585)	NEW	9.04	0.008	CACNA1C, CALM1
macromolecule localization (GO:0033036)	-	2.34	0.013	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, SCN5A
regulation of calcium ion transport into cytosol (GO:0010522)	-	5.23	0.026	CACNA1C, CALM1, CAV3, ANK2
regulation of sodium ion transmembrane transport (GO:1902305)	-	5.86	0.0	CALM1, SCN4B, SNTA1, SCN5A, CAV3
muscle contraction (GO:0006936)	-	4.37	0.0	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2, SCN5A, SNTA1, SCN4B
positive regulation of transport (GO:0051050)	-	2.9	0.004	CACNA1C, SCN5A, SCN4B, KCNQ1, KCNH2, CAV3, KCNJ2, ANK2, CALM1, KCNE1
sensory perception of sound (GO:0007605)	-	4.82	0.002	AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, KCNE1
neuronal action potential (GO:0019228)	NEW	6.4	0.047	CACNA1C, CALM1, SCN5A
inorganic ion transmembrane transport (GO:0098660)	-	3.38	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
sensory perception (GO:0007600)	-	2.93	0.002	CACNA1C, AKAP9, SCN5A, CALM1, KCNQ1, KCNH2, CAV3, ANK2, KCNE1
adult walking behavior (GO:0007628)	NEW	6.23	0.007	CACNA1C, SCN5A, CALM1, ANK2
regulation of peptide hormone secretion (GO:0090276)	NEW	4.41	0.01	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
regulation of potassium ion transmembrane transport (GO:1901379)	-	5.62	0.0	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2
protein localization to plasma membrane (GO:0072659)	-	5.29	0.002	CALM1, SCN5A, CAV3, ANK2
regulation of cardiac muscle contraction (GO:0055117)	-	5.57	0.0	CACNA1C, CALM1, SCN5A, CAV3, ANK2
system process (GO:0003008)	-	2.3	0.0	CACNA1C, SCN5A, CALM1, KCNH2, KCNQ1, KCNJ2, ANK2, KCNE1, SNTA1, SCN4B
single organism signaling (GO:0044700)	-	3.25	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
single-multicellular organism process (GO:0044707)	-	1.78	0.002	CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1, SNTA1, SCN4B
cellular response to cAMP (GO:0071320)	-	5.82	0.006	KCNQ1, CALM1, KCNE1, KCNH2
muscle system process (GO:0003012)	-	4.18	0.0	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B
response to organophosphorus (GO:0046683)	-	4.79	0.001	CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	-	6.68	0.004	CACNA1C, CALM1, ANK2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	-	6.9	0.0	CACNA1C, CALM1, ANK2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	-	6.59	0.0	CACNA1C, CALM1, CAV3, ANK2
regulation of membrane potential (GO:0042391)	-	3.89	0.0	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, SCN4B, SNTA1
regulation of skeletal muscle contraction (GO:0014819)	NEW	7.33	0.014	KCNJ2, CAV3
regulation of ion transmembrane transporter activity (GO:0032412)	-	4.55	0.0	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, CAV3, ANK2, SCN4B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	-	6.84	0.0	CALM1, KCNQ1, KCNE1, KCNH2, KCNE2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
regulation of membrane repolarization (GO:0060306)	-	6.4	0.0	SCN5A, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, SNTA1, SCN4B
positive regulation of transmembrane transport (GO:0034764)	-	4.99	0.0	KCNJ2, CALM1, KCNQ1, KCNE1, KCNH2
membrane hyperpolarization (GO:0060081)	NEW	7.33	0.047	CACNA1C, CALM1, CAV3
vasoconstriction (GO:0042310)	NEW	6.36	0.041	CALM1, CAV3, ANK2
regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)	-	7.78	0.008	SCN5A, CAV3
calcium ion transport into cytosol (GO:0060402)	NEW	5.78	0.002	CACNA1C, CALM1, CAV3, ANK2
energy reserve metabolic process (GO:0006112)	NEW	5.44	0.001	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.0	CACNA1C, SCN5A, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1, SCN4B
regulation of sodium ion transmembrane transporter activity (GO:2000649)	-	6.09	0.001	CALM1, SCN5A, SCN4B, CAV3
regulation of biological quality (GO:0065008)	-	1.68	0.0	CACNA1C, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1, KCNE1, SNTA1, SCN4B
transport (GO:0006810)	-	1.51	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B
regulation of delayed rectifier potassium channel activity (GO:1902259)	-	6.84	0.003	KCNQ1, KCNE1, CALM1, KCNE2, KCNH2
potassium ion transport (GO:0006813)	-	4.68	0.0	CACNA1C, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1
sensory perception of mechanical stimulus (GO:0050954)	-	4.79	0.003	AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, KCNE1
ion transport (GO:0006811)	-	2.66	0.0	CACNA1C, AKAP9, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1
regulation of heart contraction (GO:0008016)	-	4.35	0.0	CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372)	-	7.94	0.005	CALM1, KCNQ1, SCN5A
regulation of insulin secretion (GO:0050796)	NEW	4.57	0.005	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
sodium ion transport (GO:0006814)	-	4.75	0.0	CACNA1C, CALM1, CAV3, ANK2, SCN5A, SNTA1, SCN4B
cellular potassium ion transport (GO:0071804)	-	4.79	0.0	CACNA1C, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	CALM1, CACNA1C, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
establishment of localization (GO:0051234)	-	1.48	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B
cortisol metabolic process (GO:0034650)	NEW	8.34	0.02	CACNA1C, CALM1
cortisol biosynthetic process (GO:0034651)	NEW	8.63	0.02	CACNA1C, CALM1
energy derivation by oxidation of organic compounds (GO:0015980)	NEW	4.93	0.005	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
regulation of transmembrane transporter activity (GO:0022898)	-	4.52	0.0	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, CAV3, ANK2, SCN4B
cellular response to nitrogen compound (GO:1901699)	-	3.79	0.014	AKAP9, CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1
regulation of inward rectifier potassium channel activity (GO:1901979)	NEW	9.04	0.008	KCNQ1, KCNE2
negative regulation of cation channel activity (GO:2001258)	-	6.26	0.011	CACNA1C, CALM1, CAV3
positive regulation of cation channel activity (GO:2001259)	-	6.17	0.034	CALM1, CAV3, ANK2
regulation of cation channel activity (GO:2001257)	-	5.27	0.0	CACNA1C, CALM1, KCNQ1, KCNE2, CAV3, ANK2, KCNE1
cation transport (GO:0006812)	-	3.11	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
regulation of muscle system process (GO:0090257)	-	4.51	0.001	CACNA1C, SCN5A, CAV3, KCNJ2, ANK2, CALM1
multicellular organismal signaling (GO:0035637)	-	5.36	0.0	SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, SCN4B
ion homeostasis (GO:0050801)	-	3.42	0.031	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
synaptic transmission (GO:0007268)	NEW	3.98	0.0	CACNA1C, AKAP9, CALM1, ANK2, KCNQ1, KCNH2, CAV3, KCNJ2, KCNJ5, SCN5A, SNTA1
striated muscle contraction (GO:0006941)	-	5.37	0.0	SCN5A, CALM1, KCNH2, KCNQ1, CAV3, ANK2, SCN4B
regulation of striated muscle contraction (GO:0006942)	-	5.38	0.0	CACNA1C, SCN5A, CAV3, KCNJ2, ANK2, CALM1
signaling (GO:0023052)	-	3.25	0.0	CACNA1C, AKAP9, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN5A, SNTA1, SCN4B
cell communication by electrical coupling (GO:0010644)	NEW	7.02	0.001	CACNA1C, CALM1, CAV3
response to purine-containing compound (GO:0014074)	-	4.67	0.002	CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	SCN5A, CALM1, KCNH2, KCNQ1, CAV3, ANK2, SCN4B
regulation of cardiac muscle cell contraction (GO:0086004)	-	6.51	0.001	CALM1, SCN5A, ANK2
ventricular cardiac muscle cell action potential (GO:0086005)	-	7.02	0.0	SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, CAV3, ANK2, KCNE1, SNTA1
cardiac muscle cell action potential (GO:0086001)	-	6.33	0.0	CALM1, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN5A, SNTA1, SCN4B
cardiac muscle cell action potential involved in contraction (GO:0086002)	-	6.47	0.0	SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
potassium ion transmembrane transport (GO:0071805)	-	4.79	0.0	CACNA1C, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
membrane repolarization (GO:0086009)	-	7.02	0.0	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
localization (GO:0051179)	-	1.4	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SCN4B
regulation of heart rate (GO:0002027)	-	5.29	0.0	SCN5A, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1, SCN4B
regulation of transporter activity (GO:0032409)	-	4.45	0.0	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, CAV3, ANK2, SCN4B
monovalent inorganic cation transport (GO:0015672)	-	3.74	0.0	CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
regulation of sodium ion transport (GO:0002028)	-	5.4	0.0	SCN5A, CALM1, CAV3, ANK2, SCN4B, SNTA1
positive regulation of sodium ion transport (GO:0010765)	-	6.23	0.012	SCN5A, SCN4B, ANK2
multicellular organismal process (GO:0032501)	-	1.45	0.002	CACNA1C, SCN5A, CALM1, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, ANK2, SCN4B, SNTA1
regulation of actin filament-based movement (GO:1903115)	-	6.33	0.004	CALM1, SCN5A, ANK2
neurological system process (GO:0050877)	-	2.64	0.008	CACNA1C, AKAP9, SCN5A, KCNE1, KCNQ1, KCNH2, CAV3, ANK2, CALM1, SNTA1
positive regulation of ion transport (GO:0043270)	-	4.36	0.0	CALM1, SCN5A, KCNE1, KCNQ1, KCNH2, KCNJ2, ANK2, SCN4B
regulation of system process (GO:0044057)	-	3.53	0.0	CACNA1C, SCN5A, CALM1, KCNQ1, KCNE1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, SCN4B, SNTA1
metal ion transport (GO:0030001)	-	3.36	0.0	CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
negative regulation of hormone secretion (GO:0046888)	NEW	5.41	0.018	CACNA1C, CALM1, KCNQ1, CAV3
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	-	7.09	0.0	KCNJ2, SCN5A, SCN4B, ANK2
membrane repolarization during action potential (GO:0086011)	-	7.43	0.0	KCNJ2, KCNH2, KCNE1, KCNE2, KCNQ1
membrane depolarization during action potential (GO:0086010)	-	6.07	0.0	CACNA1C, SCN4B, KCNH2, KCNJ2, ANK2, SCN5A, SNTA1
transmembrane transport (GO:0055085)	-	2.72	0.0	CACNA1C, AKAP9, SCN5A, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1, SCN4B
atrial cardiac muscle cell action potential (GO:0086014)	-	7.65	0.0	KCNQ1, SCN5A, CAV3, ANK2
protein oligomerization (GO:0051259)	NEW	3.71	0.043	CACNA1C, CALM1, KCNH2, CAV3, KCNJ2, ANK2, SNTA1
regulation of peptidyl-cysteine S-nitrosylation (GO:2000169)	NEW	8.12	0.008	SNTA1, CALM1
cellular response to organic cyclic compound (GO:0071407)	-	3.93	0.012	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1
regulation of heart rate by cardiac conduction (GO:0086091)	-	6.33	0.0	SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SCN4B
regulation of hormone secretion (GO:0046883)	NEW	4.18	0.029	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
calcium-mediated signaling (GO:0019722)	-	5.24	0.026	CACNA1C, CALM1, ANK2
regulation of calcium ion transmembrane transport (GO:1903169)	-	4.98	0.004	CACNA1C, CALM1, CAV3, ANK2
regulation of potassium ion transport (GO:0043266)	-	5.31	0.0	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, ANK2, CALM1
cellular response to drug (GO:0035690)	-	5.48	0.011	KCNQ1, CALM1, KCNE2, KCNH2
potassium ion import (GO:0010107)	-	6.4	0.0	KCNJ2, KCNH2, CAV3, KCNE2
AV node cell to bundle of His cell communication (GO:0086067)	NEW	8.34	0.005	SCN5A, SCN4B
cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	NEW	7.16	0.001	CACNA1C, CALM1, CAV3
cell communication involved in cardiac conduction (GO:0086065)	-	6.73	0.0	CACNA1C, CALM1, SCN5A, SCN4B, ANK2
regulation of ion transport (GO:0043269)	-	3.4	0.0	AKAP9, CACNA1C, SCN5A, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
positive regulation of potassium ion transport (GO:0043268)	-	6.09	0.0	KCNJ2, KCNH2, KCNE1, ANK2, KCNQ1
regulation of sensory perception of pain (GO:0051930)	NEW	6.17	0.017	CALM1, SCN5A, CAV3
regulation of sensory perception (GO:0051931)	NEW	6.17	0.017	CALM1, SCN5A, CAV3
cellular response to organonitrogen compound (GO:0071417)	-	3.87	0.007	AKAP9, CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2, KCNE1
regulation of muscle contraction (GO:0006937)	-	4.75	0.0	CACNA1C, SCN5A, CAV3, KCNJ2, ANK2, CALM1
protein homooligomerization (GO:0051260)	NEW	4.21	0.002	CACNA1C, CALM1, KCNH2, CAV3, KCNJ2, ANK2, SNTA1
sodium ion transmembrane transport (GO:0035725)	-	5.23	0.001	CALM1, SCN4B, SCN5A, CAV3, ANK2
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	-	6.36	0.007	CALM1, CAV3, ANK2
negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	NEW	6.59	0.006	CACNA1C, CALM1, CAV3
smooth muscle contraction (GO:0006939)	NEW	5.9	0.005	CACNA1C, CALM1, CAV3, ANK2
negative regulation of potassium ion transmembrane transport (GO:1901380)	-	6.68	0.011	KCNH2, CAV3
positive regulation of potassium ion transmembrane transport (GO:1901381)	-	6.43	0.0	KCNJ2, KCNH2, KCNE1, KCNQ1
cytosolic calcium ion transport (GO:0060401)	NEW	5.74	0.002	CACNA1C, CALM1, CAV3, ANK2
cardiac conduction (GO:0061337)	-	5.54	0.0	SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SCN4B
cellular protein localization (GO:0034613)	-	3.11	0.021	CALM1, KCNH2, KCNQ1, KCNE2, CAV3, ANK2, SCN5A
cation homeostasis (GO:0055080)	-	3.46	0.021	KCNJ2, CACNA1C, KCNH2, CAV3, ANK2
regulation of metal ion transport (GO:0010959)	-	3.94	0.0	CACNA1C, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, SCN4B, SNTA1
ion transmembrane transport (GO:0034220)	-	3.08	0.0	AKAP9, CACNA1C, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
single-organism transport (GO:0044765)	-	2.18	0.0	CACNA1C, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B
single-organism cellular process (GO:0044763)	-	0.65	0.043	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, ALG10, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
monovalent inorganic cation homeostasis (GO:0055067)	-	4.93	0.002	KCNJ2, CALM1, SCN5A, CAV3, KCNH2
metal ion homeostasis (GO:0055065)	-	3.61	0.013	CACNA1C, SCN5A, KCNH2, CAV3, KCNJ2, ANK2, CALM1
cell-cell signaling (GO:0007267)	NEW	3.35	0.0	CACNA1C, AKAP9, CALM1, ANK2, KCNH2, KCNQ1, CAV3, KCNJ2, KCNJ5, SCN5A, SNTA1
cell communication (GO:0007154)	-	3.04	0.0	CACNA1C, AKAP9, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, CAV3, KCNJ2, KCNJ5, CALM1, SNTA1
SA node cell to atrial cardiac muscle cell communication (GO:0086070)	NEW	9.04	0.002	SCN5A, ANK2
regulation of calcium ion transmembrane transporter activity (GO:1901019)	-	5.49	0.004	CACNA1C, CALM1, CAV3, ANK2
regulation of peptide secretion (GO:0002791)	NEW	4.38	0.011	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, ANK2
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	-	5.44	0.009	CACNA1C, CALM1, CAV3, ANK2
regulation of calcium ion transport (GO:0051924)	-	4.38	0.007	CACNA1C, CALM1, CAV3, ANK2
regulation of potassium ion transmembrane transporter activity (GO:1901016)	-	6.02	0.0	KCNE1, KCNH2, KCNQ1, CAV3, KCNE2, ANK2
regulation of ion homeostasis (GO:2000021)	-	4.44	0.0	CACNA1C, CALM1, SCN5A, CAV3, ANK2
T-tubule organization (GO:0033292)	-	8.63	0.004	CAV3, ANK2
cation transmembrane transport (GO:0098655)	-	3.43	0.0	CACNA1C, AKAP9, SCN5A, SCN4B, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, KCNE1, SNTA1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
membrane part (GO:0044425)	0.95	15	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
cell part (GO:0044464)	0.11	15	AKAP9, CACNA1C, SCN5A, KCNE1, ANK2, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
membrane (GO:0016020)	0.68	14	CACNA1C, SCN5A, CALM1, ANK2, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
plasma membrane part (GO:0044459)	1.95	14	AKAP9, CACNA1C, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
protein complex (GO:0043234)	1.51	13	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
macromolecular complex (GO:0032991)	1.35	13	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
plasma membrane protein complex (GO:0098797)	3.55	13	AKAP9, CACNA1C, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
membrane protein complex (GO:0098796)	2.84	13	AKAP9, CACNA1C, SCN5A, KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
plasma membrane (GO:0005886)	1.39	13	CACNA1C, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SCN5A, SNTA1, SCN4B
intracellular part (GO:0044424)	0.28	13	CACNA1C, AKAP9, SCN5A, CALM1, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
cytoplasmic part (GO:0044444)	0.82	12	CACNA1C, AKAP9, SCN5A, CALM1, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1
intracellular organelle (GO:0043229)	0.51	12	CACNA1C, AKAP9, SCN5A, CALM1, ALG10, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
organelle (GO:0043226)	0.4	12	CACNA1C, AKAP9, SCN5A, CALM1, ALG10, KCNQ1, KCNE2, KCNJ2, CAV3, ANK2, KCNE1, SNTA1
transmembrane transporter complex (GO:1902495)	4.06	11	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, KCNJ5, SCN4B
integral component of membrane (GO:0016021)	1.14	11	CACNA1C, SCN5A, KCNE1, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B
transporter complex (GO:1990351)	4.04	11	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, KCNJ5, SCN4B
ion channel complex (GO:0034702)	4.18	11	AKAP9, CACNA1C, SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, CALM1, KCNE1, SCN4B
cation channel complex (GO:0034703)	4.69	11	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, KCNJ2, KCNJ5, KCNE1, SCN4B
intrinsic component of membrane (GO:0031224)	1.13	11	CACNA1C, SCN5A, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SCN4B
membrane-bounded organelle (GO:0043227)	0.47	9	AKAP9, SCN5A, CALM1, ALG10, KCNQ1, KCNE2, KCNJ2, CAV3, KCNE1
intracellular membrane-bounded organelle (GO:0043231)	0.6	9	AKAP9, SCN5A, CALM1, ALG10, KCNQ1, KCNE2, KCNJ2, CAV3, KCNE1
organelle part (GO:0044422)	0.79	9	CACNA1C, AKAP9, SCN5A, CALM1, ALG10, KCNQ1, CAV3, ANK2, KCNE1
potassium channel complex (GO:0034705)	5.32	8	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNE1
voltage-gated potassium channel complex (GO:0008076)	5.34	8	AKAP9, CALM1, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNE1
cytoplasm (GO:0005737)	1.01	7	CACNA1C, AKAP9, CALM1, KCNQ1, CAV3, ANK2, SNTA1
cell junction (GO:0030054)	2.75	6	SCN4B, CAV3, KCNJ2, ANK2, SCN5A, SNTA1
contractile fiber part (GO:0044449)	4.53	6	CACNA1C, CALM1, KCNE1, CAV3, ANK2, SCN5A
plasma membrane region (GO:0098590)	2.97	5	KCNQ1, SCN5A, KCNE1, CAV3, ANK2
intercalated disc (GO:0014704)	5.93	5	KCNJ2, SCN5A, SCN4B, CAV3, ANK2
membrane raft (GO:0045121)	4.18	5	KCNQ1, SCN5A, KCNE1, CAV3, ANK2
endoplasmic reticulum (GO:0005783)	2.56	5	KCNJ2, KCNQ1, SCN5A, CAV3, ALG10
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	5	CACNA1C, AKAP9, SNTA1, CALM1, ANK2
T-tubule (GO:0030315)	6.09	5	KCNJ2, SCN5A, CAV3, ANK2, KCNJ5
cell-cell contact zone (GO:0044291)	5.69	5	KCNJ2, SCN5A, SCN4B, CAV3, ANK2
membrane region (GO:0098589)	3.95	5	KCNQ1, SCN5A, KCNE1, CAV3, ANK2
intracellular organelle part (GO:0044446)	0.81	5	AKAP9, KCNQ1, CALM1, CAV3, ALG10
non-membrane-bounded organelle (GO:0043228)	1.76	5	CACNA1C, AKAP9, SNTA1, CALM1, ANK2
cell-cell junction (GO:0005911)	3.85	5	KCNJ2, SCN5A, SCN4B, CAV3, ANK2
membrane microdomain (GO:0098857)	4.17	5	KCNQ1, SCN5A, KCNE1, CAV3, ANK2
cell surface (GO:0009986)	3.44	5	SCN5A, KCNE1, CAV3, KCNE2, KCNH2
Z disc (GO:0030018)	5.11	5	CACNA1C, SCN5A, KCNE1, CAV3, ANK2
cytoskeleton (GO:0005856)	2.55	4	AKAP9, SNTA1, CALM1, ANK2
neuron part (GO:0097458)	2.64	4	KCNJ2, CACNA1C, CALM1, ANK2
cytosol (GO:0005829)	1.68	4	AKAP9, CALM1, CAV3, ANK2
sarcolemma (GO:0042383)	5.2	4	SNTA1, SCN5A, CAV3, ANK2
intracellular (GO:0005622)	2.37	4	KCNH2, SNTA1, SCN5A, ANK2
Golgi apparatus (GO:0005794)	2.7	3	KCNJ2, AKAP9, CAV3
lytic vacuole (GO:0000323)	3.89	3	KCNQ1, KCNE1, KCNE2
vesicle (GO:0031982)	1.64	3	KCNQ1, CALM1, CAV3
vacuole (GO:0005773)	2.92	3	KCNQ1, KCNE1, KCNE2
lysosome (GO:0005764)	3.89	3	KCNQ1, KCNE1, KCNE2
synapse part (GO:0044456)	3.42	3	KCNJ2, CACNA1C, ANK2
synapse (GO:0045202)	3.58	3	SNTA1, CAV3, ANK2
neuron projection (GO:0043005)	3.12	3	KCNJ2, CALM1, ANK2
cell projection (GO:0042995)	2.47	3	KCNJ2, CALM1, ANK2
sodium channel complex (GO:0034706)	6.97	2	SCN5A, SCN4B
lateral plasma membrane (GO:0016328)	5.89	2	SNTA1, SCN5A
organelle membrane (GO:0031090)	1.97	2	KCNQ1, CAV3
apical plasma membrane (GO:0016324)	4.13	2	KCNE1, ANK2
centrosome (GO:0005813)	3.75	2	AKAP9, CALM1
cell projection part (GO:0044463)	2.97	2	KCNJ2, CALM1
calcium channel complex (GO:0034704)	5.72	2	CACNA1C, CALM1
basolateral plasma membrane (GO:0016323)	4.56	2	KCNQ1, ANK2
neuromuscular junction (GO:0031594)	5.81	2	SNTA1, CAV3
caveola (GO:0005901)	5.55	2	SCN5A, CAV3
Golgi apparatus part (GO:0044431)	3.0	2	AKAP9, CAV3
cytoskeletal part (GO:0044430)	2.49	2	AKAP9, CALM1
plasma membrane raft (GO:0044853)	5.42	2	SCN5A, CAV3
microtubule organizing center (GO:0005815)	3.42	2	AKAP9, CALM1
intrinsic component of plasma membrane (GO:0031226)	2.53	2	KCNJ2, SCN4B
voltage-gated sodium channel complex (GO:0001518)	7.16	2	SCN5A, SCN4B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
membrane raft (GO:0045121)	-	4.18	0.03	CACNA1C, CALM1, SCN5A, CAV3, ANK2
envelope (GO:0031975)	NEW	4.62	0.027	CALM1, KCNH2, CAV3, ANK2
intercalated disc (GO:0014704)	-	5.93	0.0	SCN5A, CALM1, CAV3, KCNJ2, ANK2, SCN4B, SNTA1
potassium channel complex (GO:0034705)	-	5.32	0.0	AKAP9, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
ion channel complex (GO:0034702)	-	4.18	0.0	CACNA1C, AKAP9, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SCN5A, SNTA1, SCN4B
synapse (GO:0045202)	-	3.58	0.0	CACNA1C, SCN5A, KCNH2, KCNQ1, CAV3, CALM1, SNTA1
sarcolemma (GO:0042383)	-	5.2	0.0	CACNA1C, SCN5A, KCNQ1, CAV3, ANK2, CALM1, SNTA1
intrinsic component of plasma membrane (GO:0031226)	-	2.53	0.0	CALM1, SCN4B, SCN5A, CAV3, ANK2
Z disc (GO:0030018)	-	5.11	0.0	CACNA1C, CALM1, KCNH2, KCNE1, KCNQ1, CAV3, ANK2, SCN5A
synaptic membrane (GO:0097060)	NEW	4.22	0.0	CACNA1C, AKAP9, SCN5A, CAV3, ANK2, CALM1, SNTA1
cation channel complex (GO:0034703)	-	4.69	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1, SCN4B
myelin sheath (GO:0043209)	NEW	4.76	0.002	CALM1, CAV3, ANK2
membrane (GO:0016020)	-	0.68	0.017	CACNA1C, SCN5A, CALM1, ANK2, ALG10, KCNH2, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1, SNTA1
neuron part (GO:0097458)	-	2.64	0.007	CACNA1C, AKAP9, CALM1, KCNQ1, KCNH2, CAV3, KCNJ2, ANK2, SCN5A, SNTA1
synapse part (GO:0044456)	-	3.42	0.014	CACNA1C, AKAP9, SCN5A, CAV3, ANK2, CALM1, SNTA1
intrinsic component of membrane (GO:0031224)	-	1.13	0.0	SCN5A, CALM1, CAV3, KCNJ2, ANK2, SCN4B
neuron projection (GO:0043005)	-	3.12	0.02	CACNA1C, SCN5A, KCNH2, KCNQ1, CAV3, KCNJ2, ANK2, CALM1
nuclear envelope (GO:0005635)	NEW	4.72	0.019	CALM1, KCNH2, CAV3, ANK2
plasma membrane part (GO:0044459)	-	1.95	0.0	AKAP9, CACNA1C, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1, SCN4B
cell-cell contact zone (GO:0044291)	-	5.69	0.0	SCN5A, CALM1, CAV3, KCNJ2, ANK2, SCN4B, SNTA1
transmembrane transporter complex (GO:1902495)	-	4.06	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
T-tubule (GO:0030315)	-	6.09	0.0	CACNA1C, SCN5A, CAV3, KCNJ2, ANK2, CALM1, SNTA1
cell body (GO:0044297)	NEW	3.74	0.0	CACNA1C, CALM1, KCNQ1, KCNH2, CAV3, KCNJ2, ANK2, SCN5A, SNTA1
cell surface (GO:0009986)	-	3.44	0.004	SCN5A, CALM1, KCNH2, KCNQ1, KCNE2, CAV3, KCNE1, SNTA1
transporter complex (GO:1990351)	-	4.04	0.0	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
voltage-gated potassium channel complex (GO:0008076)	-	5.34	0.0	AKAP9, CALM1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, KCNE1
organelle envelope (GO:0031967)	NEW	4.63	0.027	CALM1, KCNH2, CAV3, ANK2
basolateral plasma membrane (GO:0016323)	-	4.56	0.011	CALM1, SNTA1, KCNQ1, CAV3, ANK2
postsynaptic membrane (GO:0045211)	NEW	4.47	0.0	CACNA1C, AKAP9, SCN5A, CAV3, ANK2, CALM1, SNTA1
neuron projection membrane (GO:0032589)	NEW	6.19	0.0	CALM1, KCNH2, CAV3, ANK2
cell-cell junction (GO:0005911)	-	3.85	0.013	AKAP9, CALM1, CAV3, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B
plasma membrane (GO:0005886)	-	1.39	0.0	CACNA1C, SCN5A, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, CALM1, SNTA1
voltage-gated sodium channel complex (GO:0001518)	-	7.16	0.02	SCN5A, SCN4B
protein complex (GO:0043234)	-	1.51	0.027	CACNA1C, AKAP9, SCN5A, CALM1, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
neuromuscular junction (GO:0031594)	-	5.81	0.0	KCNQ1, SCN5A, SNTA1, CALM1, CAV3
macromolecular complex (GO:0032991)	-	1.35	0.0	CACNA1C, AKAP9, SCN5A, CALM1, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
axolemma (GO:0030673)	NEW	7.16	0.001	KCNH2, CAV3, ANK2
neuronal cell body (GO:0043025)	NEW	3.9	0.0	CACNA1C, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, ANK2, SCN5A, SNTA1
cell junction (GO:0030054)	-	2.75	0.037	CACNA1C, AKAP9, CALM1, CAV3, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B
cell projection part (GO:0044463)	-	2.97	0.001	CACNA1C, AKAP9, CALM1, KCNH2, KCNQ1, CAV3, KCNJ2, ANK2, SCN5A, SNTA1
axon part (GO:0033267)	NEW	4.4	0.0	CACNA1C, SCN5A, KCNH2, CAV3, ANK2, CALM1
contractile fiber (GO:0043292)	NEW	5.81	0.023	CALM1, CAV3, ANK2
membrane part (GO:0044425)	-	0.95	0.001	CACNA1C, AKAP9, SCN5A, KCNE1, ANK2, ALG10, KCNQ1, KCNH2, KCNE2, KCNJ2, CAV3, KCNJ5, SCN4B, SNTA1
sodium channel complex (GO:0034706)	-	6.97	0.011	SCN5A, SCN4B
costamere (GO:0043034)	NEW	6.86	0.001	CALM1, CAV3, ANK2
contractile fiber part (GO:0044449)	-	4.53	0.001	CACNA1C, SCN5A, CALM1, KCNQ1, KCNH2, CAV3, ANK2, KCNE1