Disease table of CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS OMIM ID: PS614039

Gene-disease associations table

GeneAssociated with CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
KIF2AClinVar, OMIM, HUMSAVARHGNC link5q12.11PS614039
KIF5CClinVar, OMIM, HUMSAVARHGNC link2q23.11PS614039
TUBBClinVar, OMIM, HUMSAVARHGNC link6p21.332PS614039, PS156610
TUBB3ClinVar, OMIM, HUMSAVARHGNC link16q24.32PS614039, PS135700
TUBG1ClinVar, OMIM, HUMSAVARHGNC link17q21.21PS614039
TUBB2AClinVar, OMIM, HUMSAVARHGNC link6p25.21PS614039

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22TUBB, TUBB2A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p2TUBB, TUBB2A
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62TUBB, TUBB2A
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TUBB3YES3REST, SOX11, SOX20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
KIF2AKIF5CNo1NTRK1
KIF2ATUBBNo3NTRK1, RPS6KB2, UBL4A
KIF2ATUBB3No4NTRK1, RPS6KB2, EIF3F, BAG6
KIF2ATUBG1No2NTRK1, UBR5
KIF2ATUBB2ANo1ILK
KIF5CTUBBNo4NTRK1, CUL1, YWHAQ, RANBP2
KIF5CTUBB3No1NTRK1
KIF5CTUBG1No1NTRK1
KIF5CTUBB2ANo1YWHAQ
TUBBTUBB3No36PTEN, VCP, CDK13, ASB17, XPO1, INPPL1, MCM5, EGFR, TUBA4A, SNW1, PEX14, TUBA1B, HAUS2, CRK, MCM2, HDAC6, TUBA1C, GAN, TUBA1A, IQCB1, FBXO6, RPS6KB2, SHC1, CDKN1A, ELAVL1, CEP250, AP2M1, STAU1, RARS, EMD, MAD2L1, CD81, REV, NTRK1, ALKBH3, CUL3
TUBBTUBG1Yes48HSPA1A, EGFR, CDC5L, PARK2, TP53, XPO1, MAD2L1, CUL4A, HSP90AB1, SNW1, HSPA4, MARK4, HSP90AA1, TUBB4B, OLA1, HAUS2, RPS15A, TUBGCP2, CUL4B, CCT8, TUBA1C, MAGED2, TUBA1A, TUBG1, FBXO6, EEF1A1, CDC20, YWHAZ, NEDD1, RASSF1, LAMP2, CEP250, CCT2, LGALS3BP, SYK, BRCA1, TUBGCP4, PDCD6IP, TUBGCP3, HSPA8, AURKA, TUBA4A, ESR1, NTRK1, MYC, APP, RAB8B, SNCA
TUBBTUBB2AYes41PTEN, MDM2, HGS, YWHAE, ADRB2, TP53, MCM5, EGFR, TUBA1B, PEX14, TUBB4B, CRK, MCM2, HDAC6, MAPRE1, SKI, TUBA1A, ARRB1, RPA2, IQCB1, TUBGCP2, TUBA1C, CDC20, CEP76, DISC1, SDC3, CCT2, TUBA4A, AGO3, AP2M1, CUL2, TUBGCP4, TRAF3IP1, EMD, HUWE1, CD81, REV, ALKBH3, YWHAQ, CCT3, CUL3
TUBB3TUBG1No14FBXO6, HAUS2, CEP250, TUBA1A, PLK1, TUBA4A, MAD2L1, XPO1, EGFR, NTRK1, FAF2, TUBA1C, SOX2, SNW1
TUBB3TUBB2ANo31PTEN, METTL23, TERF1, CD81, EGFR, TUBA1B, PEX14, CRK, ARRB2, HDAC6, TUBA1C, TUBA1A, IQCB1, TK1, EML1, METTL21B, SOX2, METTL22, TUBA4A, AP2M1, ALKBH3, ASB4, EMD, MCM5, FAM86B2, FAS, REV, VCPKMT, FBXO25, MCM2, CUL3
TUBG1TUBB2ANo14TUBB4B, CDK2, TP53, TUBA4A, TUBB, TUBGCP4, TUBA1A, CAD, CCT2, EGFR, TUBGCP2, TUBA1C, CDC20, SOX2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
KIF2ATUBB3No-3UBC, CKAP5, PLK1
KIF2ATUBG1No-16CLASP2, KNTC1, PAFAH1B1, CDC20, CKAP5, MAD2L1, PLK1, ZW10, CLASP1, NDE1, SKA2, UBC, BIRC5, MAPRE1, KIF18A, MAPRE3
KIF2ATUBB2ANo-3UBC, CKAP5, PLK1
TUBB3TUBG1No-10TUBA3C, DYNC1H1, CKAP5, TUBA4A, PLK1, TUBA1A, DYNC1I2, TUBA1C, UBC, TUBA1B
TUBB3TUBB2ANo-18DYNC1LI2, TUBA3C, DYNC2H1, GJA1, LRRK2, DYNC1H1, CKAP5, TUBA4A, TUBA3E, TUBA1A, DYNC1I2, RILP, DYNC1LI1, UBC, TUBA1B, TUBA1C, PLK1, DYNC1I1
TUBG1TUBB2ANo-12TUBA3C, DYNC1H1, CKAP5, TUBB4B, PLK1, TUBA4A, TUBA1A, DYNC1I2, TUBA1C, UBC, TUBA1B, TUBB4A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TUBBTUBB3No3TUBA4A, TUBA1B, TUBA1A
TUBBTUBB2AYes4TUBA4A, TUBB4B, TUBA1A, TUBA1B
TUBB3TUBB2ANo3TUBA4A, TUBA1B, TUBA1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathogenic Escherichia coli infectionhsa051306.993TUBB3, TUBB2A, TUBB
Phagosomehsa041455.273TUBB3, TUBB2A, TUBB
Gap junctionhsa045406.243TUBB3, TUBB2A, TUBB

NET-GE enrichment

Term New enriched termICP valueGenes
Pathogenic Escherichia coli infection (hsa05130) -6.990.001TUBB3, TUBB2A, TUBB
Gap junction (hsa04540) -6.240.009TUBB3, TUBB2A, TUBB
Transport and catabolismNEW3.490.032TUBB3, TUBB2A, TUBB
Phagosome (hsa04145) -5.270.001TUBB3, TUBB2A, TUBB
Cellular communityNEW3.570.027TUBB3, TUBB2A, TUBB
Infectious diseases: BacterialNEW3.760.018TUBB3, TUBB2A, TUBB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.895TUBB3, TUBB, KIF2A, TUBB2A, TUBG1
Cell Cycle, MitoticR-HSA-692784.165TUBB3, TUBB, KIF2A, TUBB2A, TUBG1
Recruitment of mitotic centrosome proteins and complexesR-HSA-3802706.684TUBB3, TUBB2A, TUBB, TUBG1
Organelle biogenesis and maintenanceR-HSA-18522414.634TUBB3, TUBB2A, TUBB, TUBG1
Mitotic G2-G2/M phasesR-HSA-4532746.044TUBB3, TUBB2A, TUBB, TUBG1
Assembly of the primary ciliumR-HSA-56178335.444TUBB3, TUBB2A, TUBB, TUBG1
Centrosome maturationR-HSA-3802876.684TUBB3, TUBB2A, TUBB, TUBG1
G2/M TransitionR-HSA-692756.064TUBB3, TUBB2A, TUBB, TUBG1
RHO GTPase EffectorsR-HSA-1952584.943TUBB3, TUBB2A, KIF2A
RHO GTPases Activate ForminsR-HSA-56632206.013TUBB3, KIF2A, TUBB2A
Resolution of Sister Chromatid CohesionR-HSA-25002576.183TUBB3, KIF2A, TUBB2A
Separation of Sister ChromatidsR-HSA-24678135.553TUBB3, KIF2A, TUBB2A
Mitotic Metaphase and AnaphaseR-HSA-25553965.453TUBB3, TUBB2A, KIF2A
Recruitment of NuMA to mitotic centrosomesR-HSA-3803208.463TUBB3, TUBB2A, TUBG1
Immune SystemR-HSA-1682562.373TUBB3, KIF2A, TUBB2A
Signaling by Rho GTPasesR-HSA-1943154.433TUBB3, KIF2A, TUBB2A
Metabolism of proteinsR-HSA-3924993.413TUBB3, TUBB2A, KIF5C
HemostasisR-HSA-1095823.983TUBB3, KIF2A, TUBB2A
M PhaseR-HSA-688864.873TUBB3, KIF2A, TUBB2A
Mitotic AnaphaseR-HSA-688825.463TUBB3, KIF2A, TUBB2A
MHC class II antigen presentationR-HSA-21322956.013TUBB3, TUBB2A, KIF2A
Mitotic PrometaphaseR-HSA-688776.083TUBB3, KIF2A, TUBB2A
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.883TUBB3, KIF2A, TUBB2A
KinesinsR-HSA-9831897.73TUBB3, KIF2A, TUBB2A
Adaptive Immune SystemR-HSA-12802183.193TUBB3, KIF2A, TUBB2A
Signal TransductionR-HSA-1625821.783TUBB3, TUBB2A, KIF2A
Signaling by HedgehogR-HSA-53583515.792TUBB3, TUBB2A
Recycling pathway of L1R-HSA-4372397.622TUBB3, TUBB2A
Formation of tubulin folding intermediates by CCT/TriCR-HSA-3899608.662TUBB3, TUBB2A
Loss of Nlp from mitotic centrosomesR-HSA-3802597.032TUBB, TUBG1
Microtubule-dependent trafficking of connexons from Golgi to the plasma membraneR-HSA-1908409.282TUBB3, TUBB2A
Intraflagellar transportR-HSA-56209247.252TUBB3, TUBB2A
Developmental BiologyR-HSA-12667383.482TUBB3, TUBB2A
Hedgehog 'off' stateR-HSA-56107876.192TUBB3, TUBB2A
Gap junction traffickingR-HSA-1908287.592TUBB3, TUBB2A
Prefoldin mediated transfer of substrate to CCT/TriCR-HSA-3899578.282TUBB3, TUBB2A
L1CAM interactionsR-HSA-3737606.192TUBB3, TUBB2A
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingR-HSA-3899588.232TUBB3, TUBB2A
Loss of proteins required for interphase microtubule organization from the centrosomeR-HSA-3802847.032TUBB, TUBG1
Membrane TraffickingR-HSA-1999915.262TUBB3, TUBB2A
Anchoring of the basal body to the plasma membraneR-HSA-56209126.512TUBB, TUBG1
Transport of connexons to the plasma membraneR-HSA-1908729.182TUBB3, TUBB2A
Translocation of GLUT4 to the plasma membraneR-HSA-14451486.772TUBB3, TUBB2A
Gap junction trafficking and regulationR-HSA-1578587.522TUBB3, TUBB2A
Post-chaperonin tubulin folding pathwayR-HSA-3899778.812TUBB3, TUBB2A
Chaperonin-mediated protein foldingR-HSA-3904667.42TUBB3, TUBB2A
Vesicle-mediated transportR-HSA-56536564.332TUBB3, TUBB2A
Protein foldingR-HSA-3912517.232TUBB3, TUBB2A
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.662TUBB, TUBG1
RHO GTPases activate IQGAPsR-HSA-56264678.342TUBB3, TUBB2A
Axon guidanceR-HSA-4224753.932TUBB3, TUBB2A
Gap junction assemblyR-HSA-1908618.032TUBB3, TUBB2A

NET-GE enrichment

Term New enriched termICP valueGenes
Separation of Sister Chromatids (R-HSA-2467813) -5.550.01TUBB3, KIF2A, TUBB2A
Loss of Nlp from mitotic centrosomes (R-HSA-380259) -7.030.047TUBB, TUBG1
Recycling pathway of L1 (R-HSA-437239) -7.620.026TUBB3, TUBB2A
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (R-HSA-190840) -9.280.003TUBB3, TUBB2A
Formation of tubulin folding intermediates by CCT/TriC (R-HSA-389960) -8.660.005TUBB3, TUBB2A
Gap junction assembly (R-HSA-190861) -8.030.012TUBB3, TUBB2A
Cell Cycle (R-HSA-1640170) -3.890.0TUBB3, TUBB, KIF2A, TUBB2A, TUBG1
Assembly of the primary cilium (R-HSA-5617833) -5.440.0TUBB3, TUBB2A, TUBB, TUBG1
Adaptive Immune System (R-HSA-1280218) -3.190.004TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270) -6.680.0TUBB3, TUBB2A, TUBB, TUBG1
Resolution of Sister Chromatid Cohesion (R-HSA-2500257) -6.180.003TUBB3, KIF2A, TUBB2A
Mitotic Metaphase and Anaphase (R-HSA-2555396) -5.450.012TUBB3, TUBB2A, KIF2A
Gap junction trafficking (R-HSA-190828) -7.590.043TUBB3, TUBB2A
Intraflagellar transport (R-HSA-5620924) -7.250.034TUBB3, TUBB2A
Cell Cycle, Mitotic (R-HSA-69278) -4.160.001TUBB3, TUBB, KIF2A, TUBB2A, TUBG1
Prefoldin mediated transfer of substrate to CCT/TriC (R-HSA-389957) -8.280.009TUBB3, TUBB2A
G2/M Transition (R-HSA-69275) -6.060.0TUBB3, TUBB2A, TUBB, TUBG1
Organelle biogenesis and maintenance (R-HSA-1852241) -4.630.045TUBB3, TUBB2A, TUBB, TUBG1
RHO GTPases Activate Formins (R-HSA-5663220) -6.010.013TUBB3, KIF2A, TUBB2A
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (R-HSA-389958) -8.230.01TUBB3, TUBB2A
Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284) -7.030.047TUBB, TUBG1
Centrosome maturation (R-HSA-380287) -6.680.0TUBB3, TUBB2A, TUBB, TUBG1
Mitotic G2-G2/M phases (R-HSA-453274) -6.040.0TUBB3, TUBB2A, TUBB, TUBG1
M Phase (R-HSA-68886) -4.870.04TUBB3, TUBB2A, KIF2A
Transport of connexons to the plasma membrane (R-HSA-190872) -9.180.003TUBB3, TUBB2A
Mitotic Anaphase (R-HSA-68882) -5.460.012TUBB3, KIF2A, TUBB2A
Gap junction trafficking and regulation (R-HSA-157858) -7.520.044TUBB3, TUBB2A
Post-chaperonin tubulin folding pathway (R-HSA-389977) -8.810.005TUBB3, TUBB2A
Chaperonin-mediated protein folding (R-HSA-390466) -7.40.028TUBB3, TUBB2A
RHO GTPase Effectors (R-HSA-195258) -4.940.035TUBB3, TUBB2A, KIF2A, TUBG1
Protein folding (R-HSA-391251) -7.230.035TUBB3, TUBB2A, TUBG1
Recruitment of NuMA to mitotic centrosomes (R-HSA-380320) -8.460.0TUBB3, TUBB2A, TUBG1
Mitotic Prometaphase (R-HSA-68877) -6.080.003TUBB3, KIF2A, TUBB2A
RHO GTPases activate IQGAPs (R-HSA-5626467) -8.340.008TUBB3, TUBB2A
MHC class II antigen presentation (R-HSA-2132295) -6.010.0TUBB3, TUBB2A, KIF5C, KIF2A
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) -5.880.001TUBB3, KIF2A, KIF5C, TUBB2A
Kinesins (R-HSA-983189) -7.70.0TUBB3, KIF2A, KIF5C, TUBB2A
Hemostasis (R-HSA-109582) -3.980.012TUBB3, KIF2A, KIF5C, TUBB2A
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.226TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
binding (GO:0005488) 0.186TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
heterocyclic compound binding (GO:1901363) 1.066TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleoside binding (GO:0001883) 2.226TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside binding (GO:0001882) 2.216TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleotide binding (GO:0000166) 1.966TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside phosphate binding (GO:1901265) 1.966TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleoside binding (GO:0032549) 2.226TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleotide binding (GO:0017076) 2.196TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
hydrolase activity (GO:0016787) 1.96TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside-triphosphatase activity (GO:0017111) 3.096TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
small molecule binding (GO:0036094) 1.896TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
catalytic activity (GO:0003824) 1.056TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.036TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
carbohydrate derivative binding (GO:0097367) 2.036TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organic cyclic compound binding (GO:0097159) 1.056TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.036TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
pyrophosphatase activity (GO:0016462) 3.046TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
protein binding (GO:0005515) 0.466TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleotide binding (GO:0032555) 2.26TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside binding (GO:0032550) 2.226TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleotide binding (GO:0032553) 2.196TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
structural constituent of cytoskeleton (GO:0005200) 5.124TUBB3, TUBB2A, TUBB, TUBG1
guanyl ribonucleotide binding (GO:0032561) 3.734TUBB3, TUBB2A, TUBB, TUBG1
GTPase activity (GO:0003924) 4.314TUBB3, TUBB2A, TUBB, TUBG1
structural molecule activity (GO:0005198) 3.14TUBB3, TUBB2A, TUBB, TUBG1
guanyl nucleotide binding (GO:0019001) 3.734TUBB3, TUBB2A, TUBB, TUBG1
GTP binding (GO:0005525) 3.784TUBB3, TUBB2A, TUBB, TUBG1
tubulin binding (GO:0015631) 4.12KIF2A, KIF5C
adenyl nucleotide binding (GO:0030554) 2.42KIF2A, KIF5C
microtubule binding (GO:0008017) 4.422KIF2A, KIF5C
cytoskeletal protein binding (GO:0008092) 3.022KIF2A, KIF5C
adenyl ribonucleotide binding (GO:0032559) 2.412KIF2A, KIF5C
microtubule motor activity (GO:0003777) 5.342KIF2A, KIF5C
ATPase activity (GO:0016887) 3.652KIF2A, KIF5C
receptor binding (GO:0005102) 2.432KIF5C, TUBB
motor activity (GO:0003774) 4.812KIF2A, KIF5C
ATP binding (GO:0005524) 2.432KIF2A, KIF5C

NET-GE enrichment

Term New enriched termICP valueGenes
structural constituent of cytoskeleton (GO:0005200) -5.120.0TUBB3, TUBB2A, TUBB, TUBG1
ATPase activity (GO:0016887) -3.650.009KIF2A, KIF5C, TUBB, TUBG1
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleoside binding (GO:0001883) -2.220.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleotide binding (GO:0000166) -1.960.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
guanyl ribonucleotide binding (GO:0032561) -3.730.029TUBB3, TUBB2A, TUBB, TUBG1
nucleoside phosphate binding (GO:1901265) -1.960.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside binding (GO:0001882) -2.210.045TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
anion binding (GO:0043168) NEW4.170.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
guanyl nucleotide binding (GO:0019001) -3.730.0TUBB3, TUBB2A, TUBB, TUBG1
structural molecule activity (GO:0005198) -3.10.002TUBB3, TUBB2A, TUBB, TUBG1
protein serine/threonine kinase activity (GO:0004674) NEW3.640.048KIF2A, KIF5C, TUBB, TUBG1
plus-end-directed microtubule motor activity (GO:0008574) NEW6.910.006KIF5C, TUBB
ribonucleoside binding (GO:0032549) -2.220.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
protein complex binding (GO:0032403) NEW3.090.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleotide binding (GO:0017076) -2.190.049TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
motor activity (GO:0003774) -4.810.0KIF2A, KIF5C, TUBB, TUBG1
microtubule motor activity (GO:0003777) -5.340.023KIF2A, KIF5C, TUBB, TUBG1
GTP binding (GO:0005525) -3.780.022TUBB3, TUBB2A, TUBB, TUBG1
hydrolase activity (GO:0016787) -1.90.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
tubulin binding (GO:0015631) -4.10.0TUBB, TUBB2A, KIF5C, KIF2A, TUBG1
microtubule binding (GO:0008017) -4.420.0TUBB, KIF2A, KIF5C, TUBB2A, TUBG1
GTPase activity (GO:0003924) -4.310.0TUBB3, TUBB2A, TUBB, TUBG1
nucleoside-triphosphatase activity (GO:0017111) -3.090.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
small molecule binding (GO:0036094) -1.890.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cytoskeletal protein binding (GO:0008092) -3.020.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
carbohydrate derivative binding (GO:0097367) -2.030.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
pyrophosphatase activity (GO:0016462) -3.040.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleotide binding (GO:0032555) -2.20.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside binding (GO:0032550) -2.220.044TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleotide binding (GO:0032553) -2.190.049TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.266TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
single-organism cellular process (GO:0044763) 0.656TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
single-organism process (GO:0044699) 0.486TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule-based process (GO:0007017) 3.546TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organelle organization (GO:0006996) 2.025TUBB3, KIF2A, KIF5C, TUBB, TUBG1
cellular component organization (GO:0016043) 1.245TUBB3, KIF2A, KIF5C, TUBB, TUBG1
cellular component organization or biogenesis (GO:0071840) 1.225TUBB3, KIF2A, KIF5C, TUBB, TUBG1
cell cycle process (GO:0022402) 2.754TUBB3, KIF2A, TUBB, TUBG1
mitotic cell cycle process (GO:1903047) 3.124TUBB3, KIF2A, TUBB, TUBG1
movement of cell or subcellular component (GO:0006928) 2.614TUBB3, KIF2A, KIF5C, TUBB
cytoskeleton organization (GO:0007010) 3.223KIF2A, TUBB, TUBG1
transport (GO:0006810) 1.513KIF2A, KIF5C, TUBB
single-organism organelle organization (GO:1902589) 2.683KIF2A, TUBB, TUBG1
microtubule cytoskeleton organization (GO:0000226) 4.133KIF2A, TUBB, TUBG1
establishment of localization (GO:0051234) 1.483KIF2A, KIF5C, TUBB
localization (GO:0051179) 1.43KIF2A, KIF5C, TUBB
cellular component assembly (GO:0022607) 2.142KIF2A, TUBB
cell cycle G2/M phase transition (GO:0044839) 4.822TUBB, TUBG1
G2/M transition of mitotic cell cycle (GO:0000086) 4.842TUBB, TUBG1
cell differentiation (GO:0030154) 2.142TUBB3, KIF2A
cell cycle phase transition (GO:0044770) 4.242TUBB, TUBG1
mitotic cell cycle phase transition (GO:0044772) 4.272TUBB, TUBG1
axon guidance (GO:0007411) 4.442TUBB3, KIF5C
mitotic nuclear division (GO:0007067) 4.052TUBB3, KIF2A
spindle assembly (GO:0051225) 5.572KIF2A, TUBB
cell division (GO:0051301) 3.682KIF2A, TUBB
organelle assembly (GO:0070925) 3.752KIF2A, TUBB
cellular developmental process (GO:0048869) 1.822TUBB3, KIF2A
nuclear division (GO:0000280) 3.852TUBB3, KIF2A
cytoskeleton-dependent intracellular transport (GO:0030705) 4.962KIF5C, TUBB
spindle organization (GO:0007051) 5.332KIF2A, TUBB
establishment of localization in cell (GO:0051649) 2.472KIF5C, TUBB
neuron projection guidance (GO:0097485) 4.432TUBB3, KIF5C
cellular localization (GO:0051641) 2.322KIF5C, TUBB
intracellular transport (GO:0046907) 2.672KIF5C, TUBB
microtubule-based movement (GO:0007018) 4.392KIF2A, KIF5C
immune system process (GO:0002376) 2.292KIF2A, TUBB
organelle fission (GO:0048285) 3.792TUBB3, KIF2A

NET-GE enrichment

Term New enriched termICP valueGenes
organophosphate catabolic process (GO:0046434) NEW5.030.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
macromolecular complex subunit organization (GO:0043933) NEW2.140.002TUBB3, TUBB, TUBB2A, KIF2A, TUBG1
nucleoside triphosphate metabolic process (GO:0009141) NEW4.610.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside triphosphate catabolic process (GO:0009143) NEW7.240.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleoside triphosphate metabolic process (GO:0009144) NEW4.760.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleoside triphosphate catabolic process (GO:0009146) NEW7.940.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cellular catabolic process (GO:0044248) NEW2.620.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside monophosphate metabolic process (GO:0009167) NEW4.70.003TUBB3, KIF2A, KIF5C, TUBB, TUBG1
nucleoside catabolic process (GO:0009164) NEW6.170.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule cytoskeleton organization (GO:0000226) -4.130.016TUBB, TUBB2A, KIF2A, TUBG1
ribose phosphate metabolic process (GO:0019693) NEW4.060.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine-containing compound metabolic process (GO:0072521) NEW4.00.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside monophosphate metabolic process (GO:0009123) NEW4.540.004TUBB3, KIF2A, KIF5C, TUBB, TUBG1
nucleobase-containing compound catabolic process (GO:0034655) NEW3.90.005TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine-containing compound catabolic process (GO:0072523) NEW5.920.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside catabolic process (GO:0046130) NEW7.160.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleotide metabolic process (GO:0009259) NEW4.110.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cellular component organization or biogenesis (GO:0071840) -1.220.025TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organic cyclic compound catabolic process (GO:1901361) NEW3.730.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
single-organism catabolic process (GO:0044712) NEW3.210.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organic substance catabolic process (GO:1901575) NEW2.450.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside metabolic process (GO:0046128) NEW4.330.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
protein complex subunit organization (GO:0071822) NEW2.60.001TUBB3, TUBB, TUBB2A, KIF2A, TUBG1
de novo posttranslational protein folding (GO:0051084) NEW7.020.019TUBB3, TUBB2A
purine nucleoside monophosphate metabolic process (GO:0009126) NEW4.690.003TUBB3, KIF2A, KIF5C, TUBB, TUBG1
purine nucleoside metabolic process (GO:0042278) NEW4.320.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cellular component organization (GO:0016043) -1.240.023TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cytoskeleton-dependent intracellular transport (GO:0030705) -4.960.042KIF5C, TUBB, TUBG1
guanosine-containing compound catabolic process (GO:1901069) NEW8.630.0TUBB3, TUBB2A, TUBB, TUBG1
guanosine-containing compound metabolic process (GO:1901068) NEW5.90.0TUBB3, TUBB2A, TUBB, TUBG1
ribonucleoside triphosphate metabolic process (GO:0009199) NEW4.770.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleoside catabolic process (GO:0006152) NEW7.160.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleoside catabolic process (GO:0042454) NEW6.550.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleoside triphosphate catabolic process (GO:0009203) NEW9.730.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside triphosphate catabolic process (GO:0009207) NEW9.730.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine ribonucleoside triphosphate metabolic process (GO:0009205) NEW4.810.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
de novo protein folding (GO:0006458) NEW6.730.023TUBB3, TUBB2A
GTP metabolic process (GO:0046039) NEW6.590.022TUBB3, TUBB2A, TUBB, TUBG1
mitotic cell cycle (GO:0000278) NEW5.920.036KIF2A, TUBB, TUBG1
protein polymerization (GO:0051258) NEW5.80.0TUBB3, TUBB2A, TUBB
ATP metabolic process (GO:0046034) NEW4.980.002TUBB3, KIF2A, KIF5C, TUBB, TUBG1
ribonucleoside monophosphate metabolic process (GO:0009161) NEW4.620.004TUBB3, KIF2A, KIF5C, TUBB, TUBG1
purine ribonucleotide catabolic process (GO:0009154) NEW6.470.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
visual perception (GO:0007601) NEW4.410.037TUBB2A, KIF5C, TUBB, TUBG1
sensory perception (GO:0007600) NEW2.930.025TUBB3, TUBB2A, KIF5C, TUBB, TUBG1
sensory perception of light stimulus (GO:0050953) NEW4.40.038TUBB2A, KIF5C, TUBB, TUBG1
purine ribonucleotide metabolic process (GO:0009150) NEW4.160.002TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleotide catabolic process (GO:0009261) NEW6.430.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organophosphate metabolic process (GO:0019637) NEW3.040.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
small molecule metabolic process (GO:0044281) NEW2.380.002TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleotide metabolic process (GO:0009117) NEW3.730.007TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside metabolic process (GO:0009116) NEW4.120.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
ribonucleoside metabolic process (GO:0009119) NEW4.210.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
heterocycle catabolic process (GO:0046700) NEW3.820.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cellular protein complex assembly (GO:0043623) NEW3.90.036TUBB3, TUBB2A, TUBB, TUBG1
nucleobase-containing small molecule metabolic process (GO:0055086) NEW3.590.01TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organonitrogen compound catabolic process (GO:1901565) NEW3.910.005TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleotide catabolic process (GO:0009166) NEW5.670.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule-based process (GO:0007017) -3.540.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organonitrogen compound metabolic process (GO:1901564) NEW2.320.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cellular nitrogen compound catabolic process (GO:0044270) NEW3.80.007TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
spindle organization (GO:0007051) -5.330.0KIF2A, TUBB, TUBG1
carbohydrate derivative catabolic process (GO:1901136) NEW4.610.002TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
carbohydrate derivative metabolic process (GO:1901135) NEW3.070.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule-based movement (GO:0007018) -4.390.0TUBB, TUBB2A, KIF5C, KIF2A, TUBG1
purine nucleotide catabolic process (GO:0006195) NEW6.070.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
purine nucleotide metabolic process (GO:0006163) NEW4.090.002TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
glycosyl compound metabolic process (GO:1901657) NEW4.040.002TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
phosphate-containing compound metabolic process (GO:0006796) NEW2.160.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside phosphate catabolic process (GO:1901292) NEW5.540.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
phosphorus metabolic process (GO:0006793) NEW2.150.001TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
aromatic compound catabolic process (GO:0019439) NEW3.790.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
nucleoside phosphate metabolic process (GO:0006753) NEW3.710.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
catabolic process (GO:0009056) NEW2.380.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
glycosyl compound catabolic process (GO:1901658) NEW6.020.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.016TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cytoskeleton (GO:0005856) 2.556TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
supramolecular fiber (GO:0099512) 3.316TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
polymeric cytoskeletal fiber (GO:0099513) 3.316TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
intracellular non-membrane-bounded organelle (GO:0043232) 1.766TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cell part (GO:0044464) 0.116TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
intracellular organelle part (GO:0044446) 0.816TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
intracellular organelle (GO:0043229) 0.516TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
non-membrane-bounded organelle (GO:0043228) 1.766TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cytoskeletal part (GO:0044430) 2.496TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
intracellular part (GO:0044424) 0.286TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule (GO:0005874) 3.816TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organelle (GO:0043226) 0.46TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
organelle part (GO:0044422) 0.796TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
membrane-bounded organelle (GO:0043227) 0.475TUBB3, TUBB, TUBB2A, KIF2A, TUBG1
intracellular membrane-bounded organelle (GO:0043231) 0.65TUBB3, TUBB, TUBB2A, KIF2A, TUBG1
protein complex (GO:0043234) 1.514KIF2A, KIF5C, TUBB, TUBG1
nucleus (GO:0005634) 1.074TUBB3, TUBB2A, KIF2A, TUBB
macromolecular complex (GO:0032991) 1.354KIF2A, KIF5C, TUBB, TUBG1
extracellular vesicle (GO:1903561) 1.893TUBB3, TUBB2A, TUBB
extracellular organelle (GO:0043230) 1.893TUBB3, TUBB2A, TUBB
extracellular exosome (GO:0070062) 1.893TUBB3, TUBB2A, TUBB
cell projection part (GO:0044463) 2.973KIF2A, KIF5C, TUBG1
membrane-bounded vesicle (GO:0031988) 1.713TUBB3, TUBB2A, TUBB
cytoplasmic part (GO:0044444) 0.823KIF2A, TUBB, TUBG1
nuclear part (GO:0044428) 1.553KIF2A, TUBB, TUBG1
ciliary part (GO:0044441) 4.053KIF2A, KIF5C, TUBG1
cell projection (GO:0042995) 2.473TUBB3, KIF5C, TUBG1
extracellular region part (GO:0044421) 1.573TUBB3, TUBB2A, TUBB
vesicle (GO:0031982) 1.643TUBB3, TUBB2A, TUBB
centrosome (GO:0005813) 3.752KIF2A, TUBG1
cytosol (GO:0005829) 1.682KIF2A, TUBG1
cell body (GO:0044297) 3.742TUBB3, TUBB
microtubule organizing center (GO:0005815) 3.422KIF2A, TUBG1
neuron part (GO:0097458) 2.642TUBB3, KIF5C
neuron projection (GO:0043005) 3.122TUBB3, KIF5C
kinesin complex (GO:0005871) 5.742KIF2A, KIF5C
microtubule associated complex (GO:0005875) 4.792KIF2A, KIF5C
spindle microtubule (GO:0005876) 5.782KIF2A, TUBG1

NET-GE enrichment

Term New enriched termICP valueGenes
protein complex (GO:0043234) -1.510.006TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
macromolecular complex (GO:0032991) -1.350.015TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
cytoskeletal part (GO:0044430) -2.490.013TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
neuron projection (GO:0043005) -3.120.013TUBB3, TUBB2A, KIF5C, TUBB, TUBG1
kinesin complex (GO:0005871) -5.740.0KIF2A, KIF5C, TUBB, TUBG1
microtubule (GO:0005874) -3.810.0TUBB2A, KIF2A, KIF5C, TUBB, TUBB3, TUBG1
microtubule associated complex (GO:0005875) -4.790.0KIF2A, KIF5C, TUBB, TUBG1