| Disease ID | Disease name | Source of annotation with G6PD | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 611162 | MALARIA, SUSCEPTIBILITY TO | OMIM | link to OMIM | 16 | FCGR2A, TIRAP, ICAM1, ACKR1, G6PD, GYPC, TNF, SLC4A1, NOS2, HBB, CISH, GYPB, FCGR2B, CR1, CD36, GYPA |
| 134700 | FAVISM, SUSCEPTIBILITY TO | OMIM | link to OMIM | 1 | G6PD |
| 300908 | ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY | OMIM, HUMSAVAR | link to OMIM | 1 | G6PD |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pentose phosphate pathway | hsa00030 | 7.86 |
| Metabolic pathways | hsa01100 | 2.49 |
| Glutathione metabolism | hsa00480 | 6.96 |
| Central carbon metabolism in cancer | hsa05230 | 6.7 |
| Carbon metabolism | hsa01200 | 6.03 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 6.73 |
| Metabolism of carbohydrates | R-HSA-71387 | 4.93 |
| Generic Transcription Pathway | R-HSA-212436 | 3.86 |
| Gene Expression | R-HSA-74160 | 2.72 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Pentose phosphate pathway (hexose monophosphate shunt) | R-HSA-71336 | 10.18 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 6.73 |
| GO term | GO ID | GO IC |
|---|---|---|
| oxidoreductase activity | GO:0016491 | 3.12 |
| coenzyme binding | GO:0050662 | 4.53 |
| NADP binding | GO:0050661 | 5.93 |
| oxidoreductase activity, acting on CH-OH group of donors | GO:0016614 | 4.83 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | GO:0016616 | 5.0 |
| glucose-6-phosphate dehydrogenase activity | GO:0004345 | 9.05 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| carbohydrate binding | GO:0030246 | 4.17 |
| nucleotide binding | GO:0000166 | 1.96 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| identical protein binding | GO:0042802 | 2.63 |
| cofactor binding | GO:0048037 | 4.16 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| glucose binding | GO:0005536 | 7.25 |
| monosaccharide binding | GO:0048029 | 5.85 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| protein homodimerization activity | GO:0042803 | 3.16 |