| Disease ID | Disease name | Source of annotation with TIRAP | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 607948 | MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO | OMIM | link to OMIM | 11 | IFNG, TIRAP, CD209, IFNGR1, MC3R, CISH, CCL2, IRGM, SLC11A1, TLR2, SP110 |
| 614382 | BACTEREMIA, SUSCEPTIBILITY TO, 1 | OMIM | link to OMIM | 1 | TIRAP |
| 611162 | MALARIA, SUSCEPTIBILITY TO | OMIM | link to OMIM | 16 | FCGR2A, TIRAP, ICAM1, ACKR1, G6PD, GYPC, TNF, SLC4A1, NOS2, HBB, CISH, GYPB, FCGR2B, CR1, CD36, GYPA |
| PS610799 | INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED | OMIM | link to OMIM | 3 | IKBKG, TIRAP, IRAK4 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Hepatitis B | hsa05161 | 5.52 |
| Tuberculosis | hsa05152 | 5.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.56 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 9.52 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 6.51 |
| Immune System | R-HSA-168256 | 2.37 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 6.51 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| Diseases of Immune System | R-HSA-5260271 | 8.34 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.34 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| MyD88:Mal cascade initiated on plasma membrane | R-HSA-166058 | 6.56 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 9.52 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Disease | R-HSA-1643685 | 3.33 |
| GO term | GO ID | GO IC |
|---|---|---|
| protein kinase C binding | GO:0005080 | 5.83 |
| enzyme binding | GO:0019899 | 2.27 |
| binding | GO:0005488 | 0.18 |
| phospholipid binding | GO:0005543 | 3.91 |
| phosphatidylinositol-4,5-bisphosphate binding | GO:0005546 | 5.81 |
| phosphatidylinositol bisphosphate binding | GO:1902936 | 5.79 |
| Toll-like receptor 4 binding | GO:0035662 | 8.35 |
| Toll-like receptor 2 binding | GO:0035663 | 8.64 |
| identical protein binding | GO:0042802 | 2.63 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| lipid binding | GO:0008289 | 3.26 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| Toll-like receptor binding | GO:0035325 | 7.66 |
| phosphatidylinositol phosphate binding | GO:1901981 | 5.05 |
| receptor binding | GO:0005102 | 2.43 |
| binding, bridging | GO:0060090 | 4.57 |
| protein binding, bridging | GO:0030674 | 4.68 |
| phosphatidylinositol binding | GO:0035091 | 4.47 |
| protein binding | GO:0005515 | 0.46 |
| protein dimerization activity | GO:0046983 | 2.72 |
| protein heterodimerization activity | GO:0046982 | 3.64 |