Disease table of MALARIA, SUSCEPTIBILITY TO OMIM ID: 611162

Gene-disease associations table

Gene	Associated with MALARIA, SUSCEPTIBILITY TO in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
NOS2	OMIM	HGNC link	17q11.2	2	611162, 145500
CR1	OMIM	HGNC link	1q32.2	2	611162, 607486
TIRAP	OMIM	HGNC link	11q24.2	4	611162, PS610799, 607948, 614382
G6PD	OMIM	HGNC link	Xq28	3	611162, 300908, 134700
FCGR2B	OMIM	HGNC link	1q23.3	2	611162, 152700
ACKR1	OMIM	HGNC link	1q23.2	3	611162, 611862, 110700
CD36	OMIM	HGNC link	7q21.11	3	PS231200, 610938, 611162
FCGR2A	OMIM	HGNC link	1q23.3	3	611162, 152700, 219700
TNF	OMIM	HGNC link	6p21.33	3	611162, 600807, 157300
SLC4A1	OMIM	HGNC link	17q21.31	11	612653, 112050, 110500, 112010, 179800, 166900, 185020, 601550, 611590, 611162, 601551
CISH	OMIM	HGNC link	3p21.2	3	614383, 607948, 611162
ICAM1	OMIM	HGNC link	19p13.2	1	611162
HBB	OMIM	HGNC link	11p15.4	6	140700, 141749, 603902, 603903, 611162, 613985
GYPA	OMIM	HGNC link	4q31.21	1	611162
GYPB	OMIM	HGNC link	4q31.21	1	611162
GYPC	OMIM	HGNC link	2q14.3	2	616089, 611162

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 78	2	FCGR2B, FCGR2A

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
4q31.21	2	GYPB, GYPA
1q23.3	2	FCGR2B, FCGR2A

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
1q23	3	FCGR2B, FCGR2A, ACKR1
4q31	2	GYPB, GYPA

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
4q3	2	GYPB, GYPA
1q2	3	FCGR2B, FCGR2A, ACKR1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	4	FCGR2B, FCGR2A, ACKR1, CR1
4q	2	GYPB, GYPA
17q	2	SLC4A1, NOS2

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	TIRAP, HBB
17	2	SLC4A1, NOS2
1	4	FCGR2B, FCGR2A, ACKR1, CR1
4	2	GYPB, GYPA

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	NOS2, FCGR2B
NFKBIA	NO	19	EBI3, CXCL8, NOS2, TRAF1, CCL5, CD58, TNFSF10, NFKB1, RELA, S100A6, MMP3, FAS, MMP9, IL1B, MMP1, IFNB1, CD40, ICAM1, PON2	2	NOS2, ICAM1
CEBPB	NO	60	GADD45G, BCL2L1, IRF4, GOT1, PRL, DDIT3, CDKN1A, SMAD4, S100A9, SAA2, PTPN13, MMP1, F8, IL5RA, TFF3, ADM, CYP19A1, INSR, SFTPD, IL6, STAR, TNF, SMAD3, PCK2, IL1B, GNLY, FURIN, SAA1, SLC19A1, PTGS2, XBP1, HSF1, PRDM1, TNFAIP6, HP, IL24, IL10, SLC10A1, DAPK1, CSH2, OXTR, IL13, MAD1L1, CRP, CXCL8, SLC5A8, CSH1, HBB, ASNS, ALB, CSF3R, IL5, IL3, PRSS50, ABCB1, TOP1, GFER, IL4, CSRP1, FASLG	2	TNF, HBB
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	CISH, ICAM1
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	NOS2, ICAM1
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	TNF, NOS2
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	CR1, ICAM1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	TNF, NOS2, ICAM1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	TNF, NOS2, ICAM1
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	2	TNF, ICAM1
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	TNF, ICAM1
PPARG	NO	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	ICAM1, CD36
GATA1	NO	52	PF4, PBXIP1, CBFB, GP1BA, GP9, KLF1, FCER1A, ITGA2B, EPO, SEMG1, TBXA2R, BACE1, DACH1, PTGFR, GP6, HBA2, DPYSL2, GYPB, TAL1, CYBB, COPS5, DICER1, CDA, FURIN, GNAS, WT1, ZNF268, BDKRB1, SPI1, GP1BB, NFE2, F13A1, GFI1B, MPL, AGGF1, CCR3, GATA1, IFNG, HEMGN, HBE1, BACH1, PPOX, CEBPA, CDC6, HBB, PRG2, FLI1, EPOR, IL1RL1, SMAD1, HBG1, HBA1	2	HBB, GYPB

regulated gene	associated to this disease	# TFs	TFs
NOS2	YES	16	APC, XBP1, STAT2, RELA, MTA1, NFKB1, YY1, FOSL2, IKBKB, NFKBIA, JUN, KLF6, JUND, FOS, KLF5, STAT1
CR1	YES	1	ETS1
G6PD	YES	1	CREM
FCGR2B	YES	2	YY1, GATA4
CD36	YES	3	RUNX3, PPARA, PPARG
TNF	YES	21	SP1, HMGB2, ETV4, NFAT5, SPI1, HSF1, HDAC11, RELA, JUN, IRF5, EGR1, CEBPB, HDAC3, NR4A1, ATF2, AR, LRRFIP1, CEBPD, E2F1, NFKB1, SIRT1
CISH	YES	2	STAT3, STAT6
ICAM1	YES	23	ETS2, MYB, REL, STAT1, TWIST1, RARG, SP1, CEBPA, ETV5, ERG, IFI16, SIRT1, TWIST2, HDAC1, RARA, SP100, NFATC1, RELA, NFKB1, ETS1, STAT3, NFKBIA, PPARG
HBB	YES	9	NFYB, CEBPG, KLF1, NFYA, NFYC, CEBPB, NFE2L2, GATA1, POU2F2
GYPA	YES	1	LMO2
GYPB	YES	1	GATA1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NOS2	G6PD	No	8	HSPA9, YWHAE, SLC9A3R1, YWHAG, HSPB1, CCT4, YWHAQ, YWHAZ
NOS2	FCGR2A	No	1	TRIM21
NOS2	TNF	No	3	HSPB1, CAV1, YWHAQ
NOS2	CISH	No	4	TCEB2, CUL5, HSPA6, TCEB1
NOS2	ICAM1	Yes	17	TUBB6, HNRNPA1, SNRPD3, RPL5, RPL31, CCT3, RPS18, NOS2, SNRPB, RPS4X, RPS3A, NPM1, RPS3, YBX1, CCT4, DDX3X, XRCC5
NOS2	HBB	No	1	UCHL5
TIRAP	CD36	No	1	APP
TIRAP	TNF	No	4	TNFSF9, TAB1, MAP3K7, TAB2
TIRAP	CISH	No	1	MYD88
G6PD	TNF	No	2	HSPB1, YWHAQ
G6PD	ICAM1	No	1	CCT4
G6PD	HBB	No	1	MCM2
FCGR2B	FCGR2A	Yes	1	PTPN11
CD36	FCGR2A	No	1	LYN
CD36	TNF	No	2	LYN, FYN
FCGR2A	TNF	No	1	LYN
FCGR2A	SLC4A1	No	1	SYK
FCGR2A	GYPB	No	1	UBQLN1
TNF	SLC4A1	No	1	CLU
TNF	CISH	No	1	UBC
TNF	ICAM1	No	1	HNRNPD
SLC4A1	HBB	No	1	HBA1
CISH	ICAM1	No	1	EGFR
ICAM1	HBB	No	1	PABPC1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NOS2	TIRAP	No	-	2	UBC, TLR4
NOS2	CD36	No	-	5	SRC, MAPK14, PPARA, TLR4, IL4
NOS2	FCGR2A	No	-	4	SRC, UBC, RAC1, TLR4
NOS2	CISH	No	-	3	TYK2, STAT6, JAK2
NOS2	ICAM1	No	-	9	RAC1, IL4, IL18, UBC, JUN, RELA, SRC, PPARA, TLR4
CR1	ICAM1	No	-	1	IL8
TIRAP	CD36	No	-	3	CD14, TLR2, TLR4
TIRAP	FCGR2A	No	-	2	UBC, TLR4
TIRAP	CISH	No	-	0
TIRAP	ICAM1	No	-	5	UBC, IL6, HMGB1, TLR2, TLR4
FCGR2B	CD36	No	-	1	LYN
FCGR2B	FCGR2A	No	-	2	SYK, LYN
FCGR2B	ICAM1	No	-	1	SYK
CD36	FCGR2A	No	-	5	SRC, LYN, YES1, FYN, TLR4
CD36	CISH	No	-	0
CD36	ICAM1	No	-	15	PTAFR, IL4, CD9, PPARA, BCAR1, BMP7, INS, EDN1, TLR4, PNPLA2, SRC, IL13, PPARG, LEP, TLR2
CD36	GYPC	No	-	1	ERVW-1
FCGR2A	ICAM1	No	-	8	RAC1, ITGAM, PLCG1, PLCG2, SRC, SYK, UBC, TLR4
CISH	ICAM1	No	-	6	STAT5B, IL2, STAT3, TP53, STAT5A, SOCS3
CISH	GYPA	No	-	1	IL2
ICAM1	GYPA	No	-	1	IL2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Malaria	hsa05144	7.15	9	ACKR1, CD36, CR1, GYPB, TNF, HBB, GYPA, GYPC, ICAM1
Tuberculosis	hsa05152	5.17	6	NOS2, FCGR2A, CR1, TIRAP, TNF, FCGR2B
Leishmaniasis	hsa05140	6.32	4	TNF, CR1, NOS2, FCGR2A
Hematopoietic cell lineage	hsa04640	6.18	4	TNF, CR1, GYPA, CD36
Pertussis	hsa05133	6.46	3	TNF, NOS2, TIRAP
African trypanosomiasis	hsa05143	7.68	3	TNF, HBB, ICAM1
Phagosome	hsa04145	5.27	3	FCGR2A, CD36, FCGR2B
Staphylococcus aureus infection	hsa05150	6.64	3	ICAM1, FCGR2A, FCGR2B
Osteoclast differentiation	hsa04380	5.64	3	TNF, FCGR2A, FCGR2B
NF-kappa B signaling pathway	hsa04064	6.21	3	TNF, ICAM1, TIRAP
Legionellosis	hsa05134	6.88	2	CR1, TNF
Systemic lupus erythematosus	hsa05322	5.95	2	TNF, FCGR2A
Natural killer cell mediated cytotoxicity	hsa04650	5.53	2	TNF, ICAM1
Rheumatoid arthritis	hsa05323	6.05	2	TNF, ICAM1
Toll-like receptor signaling pathway	hsa04620	6.0	2	TNF, TIRAP
Metabolic pathways	hsa01100	2.49	2	NOS2, G6PD
Chagas disease (American trypanosomiasis)	hsa05142	5.99	2	TNF, NOS2
TNF signaling pathway	hsa04668	5.96	2	TNF, ICAM1
Amoebiasis	hsa05146	5.82	2	TNF, NOS2
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	FCGR2A, FCGR2B
Toxoplasmosis	hsa05145	5.71	2	TNF, NOS2
Influenza A	hsa05164	5.21	2	TNF, ICAM1
HTLV-I infection	hsa05166	4.59	2	TNF, ICAM1
Hepatitis B	hsa05161	5.52	2	TNF, TIRAP
Adipocytokine signaling pathway	hsa04920	6.6	2	TNF, CD36

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.011	ACKR1, NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB, GYPC
Pertussis (hsa05133)	-	6.46	0.002	TNF, NOS2, TIRAP, ICAM1, CD36
Immune system	NEW	2.92	0.045	NOS2, FCGR2A, CD36, CR1, CISH, TIRAP, TNF, HBB, GYPA, FCGR2B, ICAM1
Infectious diseases: Parasitic	NEW	4.46	0.0	ACKR1, NOS2, CD36, FCGR2A, CR1, GYPB, TIRAP, TNF, HBB, GYPA, FCGR2B, ICAM1, GYPC
Osteoclast differentiation (hsa04380)	-	5.64	0.02	TNF, NOS2, FCGR2A, ICAM1, FCGR2B
African trypanosomiasis (hsa05143)	-	7.68	0.031	TNF, HBB, ICAM1
Leishmaniasis (hsa05140)	-	6.32	0.0	NOS2, FCGR2A, CR1, TNF, FCGR2B, ICAM1
Malaria (hsa05144)	-	7.15	0.0	ACKR1, NOS2, CD36, CR1, GYPB, TNF, HBB, GYPA, GYPC, ICAM1
Staphylococcus aureus infection (hsa05150)	-	6.64	0.012	TNF, ICAM1, FCGR2A, FCGR2B
Hematopoietic cell lineage (hsa04640)	-	6.18	0.004	TNF, CR1, GYPA, ICAM1, CD36
Tuberculosis (hsa05152)	-	5.17	0.0	NOS2, FCGR2A, CR1, TIRAP, TNF, FCGR2B, ICAM1
Hepatitis C (hsa05160)	NEW	5.68	0.013	TNF, CR1, NOS2, ICAM1, CD36
Toxoplasmosis (hsa05145)	-	5.71	0.013	TNF, NOS2, TIRAP, ICAM1, CD36
Infectious diseases: Bacterial	NEW	3.76	0.008	NOS2, FCGR2A, CR1, TIRAP, TNF, FCGR2B, ICAM1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	8	FCGR2A, CD36, CR1, CISH, TIRAP, TNF, FCGR2B, ICAM1
Innate Immune System	R-HSA-168249	3.17	4	CR1, TIRAP, FCGR2A, CD36
Metabolism	R-HSA-1430728	2.34	4	HBB, SLC4A1, G6PD, CD36
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	TNF, CISH, ICAM1
Adaptive Immune System	R-HSA-1280218	3.19	3	ICAM1, CD36, FCGR2B
Disease	R-HSA-1643685	3.33	3	NOS2, TIRAP, CD36
Hemostasis	R-HSA-109582	3.98	3	HBB, NOS2, CD36
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	TIRAP, CD36
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51	2	TIRAP, CD36
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.98	2	HBB, SLC4A1
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7	2	TNF, CD36
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11	2	TIRAP, CD36
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51	2	TIRAP, CD36
Toll-Like Receptors Cascades	R-HSA-168898	5.91	2	TIRAP, CD36
Diseases of Immune System	R-HSA-5260271	8.34	2	TIRAP, CD36
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.34	2	TIRAP, CD36
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.98	2	HBB, SLC4A1
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.98	2	HBB, SLC4A1
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	TIRAP, CD36
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.52	2	TIRAP, CD36
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.52	2	TIRAP, CD36
Signal Transduction	R-HSA-162582	1.78	2	TNF, ACKR1
Activated TLR4 signalling	R-HSA-166054	6.27	2	TIRAP, CD36
Vesicle-mediated transport	R-HSA-5653656	4.33	2	HBB, CD36
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	5.38	2	HBB, CD36
Developmental Biology	R-HSA-1266738	3.48	2	TNF, CD36
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	4.7	2	ICAM1, FCGR2B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Toll Like Receptor TLR6:TLR2 Cascade (R-HSA-168188)	-	6.56	0.011	TNF, NOS2, TIRAP, CD36
O2/CO2 exchange in erythrocytes (R-HSA-1480926)	-	9.98	0.005	HBB, SLC4A1
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673)	-	9.98	0.005	HBB, SLC4A1
Toll Like Receptor 2 (TLR2) Cascade (R-HSA-181438)	-	6.51	0.014	TNF, NOS2, TIRAP, CD36
Toll Like Receptor 4 (TLR4) Cascade (R-HSA-166016)	-	6.11	0.002	TNF, NOS2, TIRAP, ICAM1, CD36
Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179)	-	6.51	0.014	TNF, NOS2, TIRAP, CD36
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (R-HSA-2162123)	NEW	9.18	0.001	TNF, HBB, ICAM1
Toll-Like Receptors Cascades (R-HSA-168898)	-	5.91	0.004	TNF, NOS2, TIRAP, ICAM1, CD36
Diseases of Immune System (R-HSA-5260271)	-	8.34	0.0	TNF, ICAM1, TIRAP, CD36
Diseases associated with the TLR signaling cascade (R-HSA-5602358)	-	8.34	0.0	TNF, ICAM1, TIRAP, CD36
MyD88:Mal cascade initiated on plasma membrane (R-HSA-166058)	-	6.56	0.011	TNF, NOS2, TIRAP, CD36
MyD88 deficiency (TLR2/4) (R-HSA-5602498)	-	9.52	0.01	TIRAP, CD36
IRAK4 deficiency (TLR2/4) (R-HSA-5603041)	-	9.52	0.01	TIRAP, CD36
Activated TLR4 signalling (R-HSA-166054)	-	6.27	0.02	TNF, NOS2, TIRAP, CD36
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)	-	9.98	0.005	HBB, SLC4A1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	16	ACKR1, NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB, GYPC
protein binding (GO:0005515)	0.46	16	ACKR1, NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB, GYPC
identical protein binding (GO:0042802)	2.63	6	NOS2, G6PD, TIRAP, TNF, GYPA, SLC4A1
molecular transducer activity (GO:0060089)	2.32	5	ACKR1, CR1, GYPA, ICAM1, CD36
protein dimerization activity (GO:0046983)	2.72	5	GYPA, SLC4A1, TIRAP, NOS2, G6PD
receptor activity (GO:0004872)	2.32	5	CR1, ACKR1, GYPA, ICAM1, CD36
protein homodimerization activity (GO:0042803)	3.16	5	GYPA, SLC4A1, TIRAP, NOS2, G6PD
signaling receptor activity (GO:0038023)	2.49	4	CR1, ACKR1, ICAM1, CD36
organic cyclic compound binding (GO:0097159)	1.05	4	TNF, HBB, NOS2, G6PD
macromolecular complex binding (GO:0044877)	2.61	4	ICAM1, FCGR2A, CD36, FCGR2B
signal transducer activity (GO:0004871)	2.28	4	CR1, ACKR1, ICAM1, CD36
receptor binding (GO:0005102)	2.43	4	TNF, NOS2, TIRAP, ICAM1
heterocyclic compound binding (GO:1901363)	1.06	4	TNF, HBB, NOS2, G6PD
virus receptor activity (GO:0001618)	5.49	3	CR1, GYPA, ICAM1
enzyme binding (GO:0019899)	2.27	3	TNF, TIRAP, SLC4A1
catalytic activity (GO:0003824)	1.05	3	HBB, NOS2, G6PD
transmembrane signaling receptor activity (GO:0004888)	2.57	3	CR1, ACKR1, ICAM1
protein complex binding (GO:0032403)	3.09	3	ICAM1, FCGR2A, FCGR2B
transmembrane receptor activity (GO:0099600)	2.53	3	CR1, ACKR1, ICAM1
oxidoreductase activity (GO:0016491)	3.12	3	HBB, NOS2, G6PD
cation binding (GO:0043169)	1.4	2	HBB, NOS2
NADP binding (GO:0050661)	5.93	2	NOS2, G6PD
substrate-specific transporter activity (GO:0022892)	2.72	2	HBB, SLC4A1
heme binding (GO:0020037)	4.86	2	HBB, NOS2
tetrapyrrole binding (GO:0046906)	4.8	2	HBB, NOS2
carbohydrate binding (GO:0030246)	4.17	2	G6PD, GYPC
transporter activity (GO:0005215)	2.57	2	HBB, SLC4A1
cytokine binding (GO:0019955)	5.21	2	ACKR1, CD36
lipid binding (GO:0008289)	3.26	2	TIRAP, CD36
IgG binding (GO:0019864)	7.34	2	FCGR2A, FCGR2B
nucleotide binding (GO:0000166)	1.96	2	NOS2, G6PD
coenzyme binding (GO:0050662)	4.53	2	NOS2, G6PD
ion binding (GO:0043167)	1.36	2	HBB, NOS2
immunoglobulin binding (GO:0019865)	6.6	2	FCGR2A, FCGR2B
cofactor binding (GO:0048037)	4.16	2	NOS2, G6PD
metal ion binding (GO:0046872)	1.41	2	HBB, NOS2
nucleoside phosphate binding (GO:1901265)	1.96	2	NOS2, G6PD
small molecule binding (GO:0036094)	1.89	2	NOS2, G6PD

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	NEW	4.14	0.003	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
NADP binding (GO:0050661)	-	5.93	0.025	TNF, NOS2, G6PD
heme binding (GO:0020037)	-	4.86	0.04	TNF, HBB, NOS2, ICAM1
growth factor receptor binding (GO:0070851)	NEW	4.87	0.031	TNF, NOS2, ICAM1, CD36
cytokine binding (GO:0019955)	-	5.21	0.01	TNF, ACKR1, NOS2, CD36
virus receptor activity (GO:0001618)	-	5.49	0.029	GYPA, ICAM1
IgG binding (GO:0019864)	-	7.34	0.004	TNF, FCGR2A, FCGR2B
immunoglobulin binding (GO:0019865)	-	6.6	0.016	TNF, FCGR2A, FCGR2B
receptor activity (GO:0004872)	-	2.32	0.033	ACKR1, NOS2, CD36, CR1, CISH, TIRAP, TNF, GYPA, FCGR2B, ICAM1
protein binding (GO:0005515)	-	0.46	0.002	ACKR1, NOS2, GYPC, G6PD, CR1, CISH, SLC4A1, TIRAP, CD36, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1
heparin binding (GO:0008201)	NEW	4.68	0.012	TNF, NOS2, ICAM1, CD36, FCGR2B
identical protein binding (GO:0042802)	-	2.63	0.017	NOS2, G6PD, TIRAP, TNF, GYPA, SLC4A1
protein homodimerization activity (GO:0042803)	-	3.16	0.017	GYPA, SLC4A1, TIRAP, NOS2, G6PD

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
biological regulation (GO:0065007)	0.39	14	ACKR1, NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1
regulation of biological process (GO:0050789)	0.45	13	ACKR1, NOS2, CD36, G6PD, CR1, CISH, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1
cellular process (GO:0009987)	0.26	12	NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2B, ICAM1
regulation of cellular process (GO:0050794)	0.5	12	ACKR1, NOS2, CD36, G6PD, CR1, CISH, TIRAP, TNF, HBB, FCGR2A, FCGR2B, ICAM1
response to stimulus (GO:0050896)	1.22	10	ACKR1, NOS2, CD36, G6PD, CR1, TIRAP, TNF, HBB, FCGR2B, ICAM1
regulation of response to stimulus (GO:0048583)	1.54	10	NOS2, FCGR2A, CD36, CR1, CISH, TIRAP, TNF, GYPA, FCGR2B, ICAM1
signal transduction (GO:0007165)	1.28	10	ACKR1, NOS2, FCGR2A, CD36, CR1, CISH, TIRAP, TNF, FCGR2B, ICAM1
response to stress (GO:0006950)	1.8	9	ACKR1, NOS2, G6PD, CD36, CR1, TIRAP, TNF, HBB, ICAM1
regulation of cellular metabolic process (GO:0031323)	1.07	9	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, HBB, ICAM1
regulation of metabolic process (GO:0019222)	1.02	9	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, HBB, ICAM1
single-organism process (GO:0044699)	0.48	9	NOS2, G6PD, CD36, HBB, TIRAP, TNF, GYPA, SLC4A1, ICAM1
regulation of primary metabolic process (GO:0080090)	1.08	8	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, ICAM1
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, ICAM1
regulation of protein metabolic process (GO:0051246)	1.93	8	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, ICAM1
immune system process (GO:0002376)	2.29	8	NOS2, FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
single-organism cellular process (GO:0044763)	0.65	8	NOS2, G6PD, CD36, TIRAP, TNF, GYPA, SLC4A1, ICAM1
cell surface receptor signaling pathway (GO:0007166)	2.09	8	ACKR1, CD36, FCGR2A, CR1, CISH, TIRAP, TNF, ICAM1
positive regulation of biological process (GO:0048518)	1.2	8	NOS2, CD36, FCGR2A, CR1, TIRAP, TNF, HBB, ICAM1
negative regulation of biological process (GO:0048519)	1.33	8	NOS2, G6PD, CD36, CR1, CISH, TIRAP, TNF, ICAM1
regulation of biological quality (GO:0065008)	1.68	8	NOS2, CD36, HBB, TIRAP, TNF, GYPA, SLC4A1, ICAM1
multi-organism process (GO:0051704)	2.65	8	NOS2, CD36, CR1, TIRAP, TNF, GYPA, FCGR2B, ICAM1
response to oxygen-containing compound (GO:1901700)	2.57	7	NOS2, G6PD, CD36, HBB, TIRAP, TNF, ICAM1
regulation of immune response (GO:0050776)	2.98	7	FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
positive regulation of metabolic process (GO:0009893)	1.74	7	NOS2, CD36, CR1, TIRAP, TNF, HBB, ICAM1
positive regulation of cellular metabolic process (GO:0031325)	1.81	7	NOS2, CD36, CR1, TIRAP, TNF, HBB, ICAM1
defense response (GO:0006952)	2.78	7	ACKR1, NOS2, CD36, CR1, TIRAP, TNF, ICAM1
regulation of cellular protein metabolic process (GO:0032268)	1.99	7	G6PD, CD36, CR1, CISH, TIRAP, TNF, ICAM1
regulation of immune system process (GO:0002682)	2.5	7	FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
metabolic process (GO:0008152)	0.58	7	NOS2, G6PD, CD36, CR1, CISH, TNF, HBB
immune response (GO:0006955)	2.86	7	NOS2, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
response to chemical (GO:0042221)	1.98	7	NOS2, G6PD, CD36, HBB, TIRAP, TNF, ICAM1
positive regulation of cellular process (GO:0048522)	1.3	7	NOS2, CD36, CR1, TIRAP, TNF, HBB, ICAM1
negative regulation of metabolic process (GO:0009892)	1.93	6	NOS2, G6PD, CD36, CR1, CISH, TNF
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
positive regulation of response to stimulus (GO:0048584)	2.18	6	CD36, FCGR2A, CR1, TIRAP, TNF, ICAM1
cellular response to chemical stimulus (GO:0070887)	2.57	6	NOS2, G6PD, CD36, TIRAP, TNF, ICAM1
regulation of signaling (GO:0023051)	1.72	6	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
regulation of phosphate metabolic process (GO:0019220)	2.35	6	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
regulation of cell communication (GO:0010646)	1.73	6	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
cellular response to stimulus (GO:0051716)	1.97	6	NOS2, G6PD, CD36, TIRAP, TNF, ICAM1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	6	NOS2, G6PD, CD36, CR1, CISH, TNF
response to organic substance (GO:0010033)	2.2	6	NOS2, G6PD, CD36, TIRAP, TNF, ICAM1
organic substance metabolic process (GO:0071704)	0.63	6	NOS2, G6PD, CD36, CR1, CISH, TNF
positive regulation of immune system process (GO:0002684)	2.96	6	CD36, FCGR2A, CR1, TIRAP, TNF, ICAM1
regulation of protein modification process (GO:0031399)	2.32	6	G6PD, CD36, CISH, TIRAP, TNF, ICAM1
regulation of molecular function (GO:0065009)	1.78	6	NOS2, CR1, CISH, TIRAP, TNF, ICAM1
regulation of gene expression (GO:0010468)	1.37	6	NOS2, CD36, CR1, TIRAP, TNF, ICAM1
regulation of biosynthetic process (GO:0009889)	1.37	6	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
regulation of phosphorus metabolic process (GO:0051174)	2.35	6	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
regulation of multicellular organismal process (GO:0051239)	1.87	6	ACKR1, NOS2, CD36, TIRAP, TNF, ICAM1
localization (GO:0051179)	1.4	6	NOS2, CD36, HBB, TNF, GYPA, SLC4A1
primary metabolic process (GO:0044238)	0.69	6	NOS2, G6PD, CD36, CR1, CISH, TNF
response to external stimulus (GO:0009605)	2.55	6	NOS2, G6PD, CD36, TIRAP, TNF, ICAM1
regulation of response to stress (GO:0080134)	2.53	6	NOS2, CD36, CR1, TIRAP, TNF, GYPA
cellular metabolic process (GO:0044237)	0.69	6	NOS2, G6PD, CD36, HBB, CISH, TNF
negative regulation of cellular process (GO:0048523)	1.41	6	G6PD, CD36, CR1, CISH, TNF, ICAM1
positive regulation of biosynthetic process (GO:0009891)	2.29	5	HBB, TNF, NOS2, TIRAP, ICAM1
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	TNF, CR1, CISH, G6PD, CD36
multicellular organismal process (GO:0032501)	1.45	5	TNF, HBB, NOS2, ICAM1, CD36
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	TNF, HBB, NOS2, TIRAP, ICAM1
regulation of localization (GO:0032879)	1.94	5	TNF, NOS2, TIRAP, ICAM1, CD36
response to lipopolysaccharide (GO:0032496)	4.03	5	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of defense response (GO:0031347)	3.11	5	CR1, TNF, NOS2, TIRAP, CD36
negative regulation of protein metabolic process (GO:0051248)	2.82	5	TNF, CR1, NOS2, CISH, G6PD
regulation of intracellular signal transduction (GO:1902531)	2.31	5	TNF, CISH, TIRAP, ICAM1, CD36
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	TNF, CR1, ICAM1, TIRAP, CD36
response to external biotic stimulus (GO:0043207)	3.13	5	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of signal transduction (GO:0009966)	1.84	5	TNF, CISH, TIRAP, ICAM1, CD36
response to lipid (GO:0033993)	3.11	5	TNF, NOS2, TIRAP, ICAM1, CD36
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of response to external stimulus (GO:0032101)	3.06	5	TNF, CR1, NOS2, TIRAP, CD36
positive regulation of protein metabolic process (GO:0051247)	2.43	5	TNF, CR1, ICAM1, TIRAP, CD36
cellular component organization (GO:0016043)	1.24	5	TNF, HBB, GYPA, ICAM1, CD36
interspecies interaction between organisms (GO:0044419)	3.08	5	TNF, CR1, GYPA, ICAM1, FCGR2B
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	5	TNF, CR1, ICAM1, TIRAP, CD36
cellular component organization or biogenesis (GO:0071840)	1.22	5	TNF, HBB, GYPA, ICAM1, CD36
positive regulation of molecular function (GO:0044093)	2.23	5	TNF, CR1, NOS2, TIRAP, ICAM1
organic substance transport (GO:0071702)	2.15	5	TNF, HBB, NOS2, CD36, SLC4A1
cellular response to biotic stimulus (GO:0071216)	4.76	5	TNF, NOS2, TIRAP, ICAM1, CD36
transport (GO:0006810)	1.51	5	TNF, HBB, NOS2, CD36, SLC4A1
cellular response to molecule of bacterial origin (GO:0071219)	4.88	5	TNF, NOS2, TIRAP, ICAM1, CD36
positive regulation of phosphate metabolic process (GO:0045937)	2.78	5	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of catalytic activity (GO:0050790)	1.97	5	CR1, TNF, NOS2, ICAM1, CISH
multi-organism cellular process (GO:0044764)	3.14	5	TNF, CR1, GYPA, ICAM1, FCGR2B
establishment of localization (GO:0051234)	1.48	5	TNF, HBB, NOS2, CD36, SLC4A1
single-organism localization (GO:1902578)	2.09	5	TNF, HBB, GYPA, NOS2, CD36
regulation of phosphorylation (GO:0042325)	2.5	5	TNF, ICAM1, TIRAP, CISH, CD36
cellular response to oxygen-containing compound (GO:1901701)	3.22	5	TNF, NOS2, TIRAP, ICAM1, CD36
response to biotic stimulus (GO:0009607)	3.09	5	TNF, NOS2, TIRAP, ICAM1, CD36
protein metabolic process (GO:0019538)	1.45	5	TNF, CR1, NOS2, CISH, CD36
positive regulation of immune response (GO:0050778)	3.4	5	TNF, CR1, TIRAP, FCGR2A, CD36
macromolecule metabolic process (GO:0043170)	0.83	5	CR1, TNF, NOS2, CISH, CD36
regulation of cytokine production (GO:0001817)	3.4	5	TNF, ACKR1, NOS2, TIRAP, CD36
response to molecule of bacterial origin (GO:0002237)	3.99	5	TNF, NOS2, TIRAP, ICAM1, CD36
viral process (GO:0016032)	3.15	5	CR1, TNF, GYPA, ICAM1, FCGR2B
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	5	CR1, TNF, GYPA, ICAM1, FCGR2B
regulation of protein phosphorylation (GO:0001932)	2.57	5	TNF, CISH, TIRAP, ICAM1, CD36
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	5	TNF, NOS2, TIRAP, ICAM1, CD36
cellular homeostasis (GO:0019725)	3.23	4	NOS2, ICAM1, CD36, SLC4A1
regulation of RNA metabolic process (GO:0051252)	1.52	4	TNF, ICAM1, TIRAP, CD36
cellular response to lipopolysaccharide (GO:0071222)	4.94	4	TNF, NOS2, ICAM1, CD36
cytokine-mediated signaling pathway (GO:0019221)	3.6	4	TNF, ACKR1, ICAM1, CISH
regulation of transport (GO:0051049)	2.24	4	TNF, NOS2, ICAM1, CD36
negative regulation of response to stimulus (GO:0048585)	2.52	4	CR1, TNF, CISH, ICAM1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	TNF, HBB, NOS2, ICAM1
regulation of cellular component organization (GO:0051128)	2.01	4	TNF, CISH, ICAM1, CD36
homeostatic process (GO:0042592)	2.61	4	NOS2, ICAM1, CD36, SLC4A1
negative regulation of gene expression (GO:0010629)	2.48	4	TNF, CR1, NOS2, CD36
defense response to bacterium (GO:0042742)	4.31	4	TNF, NOS2, TIRAP, CD36
intracellular signal transduction (GO:0035556)	2.39	4	TNF, NOS2, CISH, CD36
regulation of cell death (GO:0010941)	2.43	4	TNF, HBB, ICAM1, G6PD
positive regulation of cell communication (GO:0010647)	2.41	4	TNF, ICAM1, TIRAP, CD36
response to organic cyclic compound (GO:0014070)	3.07	4	TNF, ICAM1, G6PD, CD36
regulation of MAPK cascade (GO:0043408)	3.22	4	TNF, ICAM1, TIRAP, CD36
single-organism metabolic process (GO:0044710)	1.63	4	TNF, NOS2, CD36, G6PD
immune response-regulating signaling pathway (GO:0002764)	3.72	4	CR1, TIRAP, FCGR2A, CD36
cellular macromolecule metabolic process (GO:0044260)	0.93	4	TNF, NOS2, CISH, CD36
cellular developmental process (GO:0048869)	1.82	4	TNF, ICAM1, TIRAP, G6PD
regulation of growth (GO:0040008)	3.26	4	TNF, CISH, TIRAP, CD36
response to bacterium (GO:0009617)	4.18	4	TNF, NOS2, TIRAP, CD36
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	TNF, ICAM1, TIRAP, CD36
cellular response to organic substance (GO:0071310)	2.78	4	TNF, NOS2, ICAM1, CD36
positive regulation of catalytic activity (GO:0043085)	2.4	4	CR1, TNF, NOS2, ICAM1
biological adhesion (GO:0022610)	2.81	4	TNF, HBB, ICAM1, CD36
regulation of cell proliferation (GO:0042127)	2.41	4	TNF, NOS2, TIRAP, ICAM1
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	4	TNF, HBB, ICAM1, CD36
activation of immune response (GO:0002253)	3.67	4	CR1, TIRAP, FCGR2A, CD36
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	4	TNF, CR1, CISH, G6PD
cellular response to lipid (GO:0071396)	3.96	4	TNF, NOS2, ICAM1, CD36
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	4	TNF, HBB, ICAM1, CD36
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	TNF, ICAM1, TIRAP, CD36
positive regulation of MAPK cascade (GO:0043410)	3.57	4	TNF, ICAM1, TIRAP, CD36
regulation of multi-organism process (GO:0043900)	3.6	4	TNF, NOS2, TIRAP, CD36
defense response to other organism (GO:0098542)	3.75	4	TNF, NOS2, TIRAP, CD36
inflammatory response (GO:0006954)	3.64	4	TNF, ACKR1, ICAM1, TIRAP
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	TNF, ICAM1, TIRAP, CD36
cell adhesion (GO:0007155)	2.82	4	TNF, HBB, ICAM1, CD36
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	TNF, ICAM1, TIRAP, CD36
response to other organism (GO:0051707)	3.48	4	TNF, NOS2, TIRAP, CD36
system process (GO:0003008)	2.3	4	HBB, NOS2, ICAM1, CD36
positive regulation of signaling (GO:0023056)	2.41	4	TNF, ICAM1, TIRAP, CD36
positive regulation of phosphorylation (GO:0042327)	2.9	4	TNF, ICAM1, TIRAP, CD36
immune response-activating signal transduction (GO:0002757)	3.8	4	CR1, TIRAP, FCGR2A, CD36
positive regulation of protein modification process (GO:0031401)	2.7	4	TNF, ICAM1, TIRAP, CD36
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	TNF, ICAM1, TIRAP, CD36
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	TNF, ICAM1, TIRAP, CD36
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	TNF, ICAM1, TIRAP, CD36
cellular response to stress (GO:0033554)	2.51	4	TNF, ICAM1, CD36, G6PD
positive regulation of signal transduction (GO:0009967)	2.5	4	TNF, ICAM1, TIRAP, CD36
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	4	TNF, ICAM1, TIRAP, CD36
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	4	TNF, ICAM1, TIRAP, CD36
protein localization (GO:0008104)	2.36	3	TNF, NOS2, CD36
positive regulation of defense response (GO:0031349)	3.83	3	TNF, TIRAP, CD36
anion transport (GO:0006820)	3.71	3	HBB, NOS2, SLC4A1
circulatory system process (GO:0003013)	4.38	3	HBB, NOS2, ICAM1
small molecule metabolic process (GO:0044281)	2.38	3	TNF, NOS2, G6PD
vascular process in circulatory system (GO:0003018)	4.65	3	HBB, NOS2, ICAM1
negative regulation of signal transduction (GO:0009968)	2.75	3	TNF, CISH, ICAM1
regulation of inflammatory response (GO:0050727)	4.03	3	TNF, CR1, NOS2
negative regulation of molecular function (GO:0044092)	2.74	3	TNF, CR1, CISH
macromolecule localization (GO:0033036)	2.34	3	TNF, NOS2, CD36
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	3	TNF, TIRAP, CD36
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	3	TNF, TIRAP, CD36
negative regulation of transport (GO:0051051)	3.6	3	TNF, ICAM1, CD36
organic anion transport (GO:0015711)	4.07	3	HBB, NOS2, SLC4A1
establishment of protein localization (GO:0045184)	2.53	3	TNF, NOS2, CD36
defense response to Gram-positive bacterium (GO:0050830)	5.54	3	TNF, TIRAP, CD36
interaction with host (GO:0051701)	4.86	3	CR1, GYPA, ICAM1
negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	6.96	3	TNF, TIRAP, CD36
modulation of growth of symbiont involved in interaction with host (GO:0044144)	6.9	3	TNF, TIRAP, CD36
single-multicellular organism process (GO:0044707)	1.78	3	TNF, HBB, CD36
entry into host cell (GO:0030260)	5.3	3	CR1, GYPA, ICAM1
chemical homeostasis (GO:0048878)	2.97	3	ICAM1, CD36, SLC4A1
extracellular matrix organization (GO:0030198)	4.01	3	TNF, ICAM1, CD36
cell-cell adhesion (GO:0098609)	3.34	3	TNF, HBB, ICAM1
viral entry into host cell (GO:0046718)	5.35	3	CR1, GYPA, ICAM1
positive regulation of cellular component organization (GO:0051130)	2.68	3	TNF, ICAM1, CD36
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	TNF, ICAM1, CD36
regulation of protein transport (GO:0051223)	3.12	3	TNF, NOS2, CD36
regulation of apoptotic process (GO:0042981)	2.5	3	TNF, ICAM1, G6PD
negative regulation of growth of symbiont in host (GO:0044130)	7.02	3	TNF, TIRAP, CD36
cellular protein metabolic process (GO:0044267)	1.63	3	TNF, NOS2, CISH
negative regulation of catalytic activity (GO:0043086)	3.0	3	CR1, TNF, CISH
positive regulation of hydrolase activity (GO:0051345)	2.91	3	CR1, TNF, ICAM1
regulation of anatomical structure size (GO:0090066)	3.78	3	HBB, NOS2, ICAM1
positive regulation of leukocyte migration (GO:0002687)	5.05	3	TNF, ICAM1, TIRAP
regulation of leukocyte migration (GO:0002685)	4.72	3	TNF, ICAM1, TIRAP
regulation of tube size (GO:0035150)	4.79	3	HBB, NOS2, ICAM1
regulation of establishment of protein localization (GO:0070201)	3.02	3	TNF, NOS2, CD36
single organism cell adhesion (GO:0098602)	3.63	3	TNF, HBB, ICAM1
regulation of developmental process (GO:0050793)	2.1	3	TNF, ICAM1, CD36
ion transport (GO:0006811)	2.66	3	HBB, NOS2, SLC4A1
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	3	TNF, TIRAP, CD36
macromolecule modification (GO:0043412)	1.73	3	TNF, NOS2, CISH
negative regulation of multi-organism process (GO:0043901)	4.7	3	TNF, TIRAP, CD36
maintenance of location (GO:0051235)	4.77	3	TNF, GYPA, CD36
regulation of growth of symbiont in host (GO:0044126)	6.96	3	TNF, TIRAP, CD36
regulation of hydrolase activity (GO:0051336)	2.53	3	TNF, CR1, ICAM1
negative regulation of protein modification process (GO:0031400)	3.4	3	TNF, CISH, G6PD
regulation of cellular response to stress (GO:0080135)	3.4	3	TNF, TIRAP, CD36
biosynthetic process (GO:0009058)	1.32	3	TNF, NOS2, G6PD
regulation of immune effector process (GO:0002697)	3.71	3	TNF, CR1, CD36
protein modification process (GO:0036211)	1.79	3	TNF, NOS2, CISH
regulation of cell motility (GO:2000145)	3.16	3	TNF, ICAM1, TIRAP
positive regulation of cell motility (GO:2000147)	3.74	3	TNF, ICAM1, TIRAP
regulation of cell adhesion (GO:0030155)	3.27	3	TNF, ICAM1, CD36
negative regulation of signaling (GO:0023057)	2.65	3	TNF, CISH, ICAM1
positive regulation of nitric oxide biosynthetic process (GO:0045429)	5.99	3	TNF, HBB, ICAM1
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	3	TNF, HBB, ICAM1
negative regulation of cell communication (GO:0010648)	2.66	3	TNF, CISH, ICAM1
single organismal cell-cell adhesion (GO:0016337)	3.69	3	TNF, HBB, ICAM1
regulation of protein complex assembly (GO:0043254)	3.83	3	TNF, ICAM1, CD36
regulation of protein localization (GO:0032880)	2.88	3	TNF, NOS2, CD36
response to endogenous stimulus (GO:0009719)	2.79	3	TNF, ICAM1, CD36
regulation of blood vessel size (GO:0050880)	4.8	3	HBB, NOS2, ICAM1
regulation of chemokine production (GO:0032642)	5.54	3	TNF, ACKR1, TIRAP
positive regulation of nitric oxide metabolic process (GO:1904407)	5.99	3	TNF, HBB, ICAM1
regulation of interleukin-6 production (GO:0032675)	5.08	3	TNF, TIRAP, CD36
cellular response to endogenous stimulus (GO:0071495)	3.33	3	TNF, ICAM1, CD36
response to abiotic stimulus (GO:0009628)	2.8	3	TNF, NOS2, ICAM1
positive regulation of protein complex assembly (GO:0031334)	4.44	3	TNF, ICAM1, CD36
regulation of locomotion (GO:0040012)	3.12	3	TNF, ICAM1, TIRAP
response to acid chemical (GO:0001101)	4.05	3	TNF, ICAM1, CD36
cellular chemical homeostasis (GO:0055082)	3.4	3	ICAM1, CD36, SLC4A1
response to oxidative stress (GO:0006979)	3.9	3	HBB, CD36, G6PD
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	3	TNF, ICAM1, TIRAP
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	3	TNF, ICAM1, TIRAP
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	3	TNF, ICAM1, TIRAP
entry into other organism involved in symbiotic interaction (GO:0051828)	5.3	3	CR1, GYPA, ICAM1
positive regulation of cytokine production (GO:0001819)	3.82	3	TNF, TIRAP, CD36
developmental process (GO:0032502)	1.36	3	TNF, ICAM1, G6PD
negative regulation of growth (GO:0045926)	4.24	3	TNF, TIRAP, CD36
positive regulation of cell death (GO:0010942)	3.32	3	TNF, HBB, ICAM1
regulation of programmed cell death (GO:0043067)	2.49	3	TNF, ICAM1, G6PD
positive regulation of reactive oxygen species biosynthetic process (GO:1903428)	5.86	3	TNF, HBB, ICAM1
extracellular structure organization (GO:0043062)	4.0	3	TNF, ICAM1, CD36
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	3	TNF, HBB, ICAM1
positive regulation of cell migration (GO:0030335)	3.77	3	TNF, ICAM1, TIRAP
regulation of cell migration (GO:0030334)	3.23	3	TNF, ICAM1, TIRAP
regulation of innate immune response (GO:0045088)	3.86	3	CR1, TIRAP, CD36
innate immune response (GO:0045087)	3.55	3	CR1, NOS2, TIRAP
cellular protein modification process (GO:0006464)	1.79	3	TNF, NOS2, CISH
single-organism developmental process (GO:0044767)	1.49	3	TNF, ICAM1, G6PD
single-organism transport (GO:0044765)	2.18	3	HBB, NOS2, CD36
positive regulation of cellular component movement (GO:0051272)	3.71	3	TNF, ICAM1, TIRAP
regulation of cellular component movement (GO:0051270)	3.08	3	TNF, ICAM1, TIRAP
positive regulation of locomotion (GO:0040017)	3.71	3	TNF, ICAM1, TIRAP
anatomical structure development (GO:0048856)	1.58	3	TNF, ICAM1, G6PD
regulation of cellular component biogenesis (GO:0044087)	3.08	3	TNF, ICAM1, CD36
entry into host (GO:0044409)	5.3	3	CR1, GYPA, ICAM1
immune effector process (GO:0002252)	3.58	3	CR1, ICAM1, FCGR2A
protein transport (GO:0015031)	2.62	3	TNF, NOS2, CD36
entry into cell of other organism involved in symbiotic interaction (GO:0051806)	5.3	3	CR1, GYPA, ICAM1
positive regulation of interleukin-6 production (GO:0032755)	5.51	3	TNF, TIRAP, CD36
positive regulation of cellular component biogenesis (GO:0044089)	3.71	3	TNF, ICAM1, CD36
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	2	TNF, ICAM1
regulation of intracellular protein transport (GO:0033157)	3.8	2	TNF, CD36
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	TNF, ICAM1
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	2	TNF, ICAM1
hemostasis (GO:0007599)	4.5	2	HBB, CD36
cellular cation homeostasis (GO:0030003)	3.6	2	CD36, SLC4A1
regulation of secretion (GO:0051046)	3.2	2	TNF, NOS2
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	TNF, ICAM1
response to bacterial lipopeptide (GO:0070339)	7.94	2	TIRAP, CD36
blood coagulation (GO:0007596)	4.52	2	HBB, CD36
regulation of homeostatic process (GO:0032844)	3.65	2	TNF, CD36
regulation of lymphocyte mediated immunity (GO:0002706)	4.99	2	TNF, CR1
regulation of cytokine biosynthetic process (GO:0042035)	5.15	2	TNF, TIRAP
regulation of production of molecular mediator of immune response (GO:0002700)	5.1	2	TNF, CD36
inorganic ion homeostasis (GO:0098771)	3.43	2	CD36, SLC4A1
response to amino acid (GO:0043200)	5.12	2	TNF, ICAM1
positive regulation of cell adhesion (GO:0045785)	3.79	2	TNF, CD36
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	TNF, TIRAP
lipid transport (GO:0006869)	4.24	2	NOS2, CD36
rhythmic process (GO:0048511)	4.02	2	NOS2, ICAM1
regulation of transcription factor import into nucleus (GO:0042990)	5.16	2	TNF, CD36
positive regulation of interleukin-12 production (GO:0032735)	6.23	2	TIRAP, CD36
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	TNF, CD36
positive regulation of chemokine production (GO:0032722)	5.82	2	TNF, TIRAP
regulation of intracellular transport (GO:0032386)	3.58	2	TNF, CD36
regulation of interleukin-12 production (GO:0032655)	5.78	2	TIRAP, CD36
positive regulation of transport (GO:0051050)	2.9	2	TNF, CD36
negative regulation of cell death (GO:0060548)	2.95	2	TNF, ICAM1
regulation of protein kinase activity (GO:0045859)	3.15	2	TNF, CISH
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	2	TNF, CR1
sensory perception (GO:0007600)	2.93	2	ICAM1, CD36
second-messenger-mediated signaling (GO:0019932)	4.65	2	NOS2, CD36
positive regulation of JNK cascade (GO:0046330)	4.98	2	TNF, TIRAP
regulation of proteolysis (GO:0030162)	3.2	2	TNF, CR1
regulation of acute inflammatory response (GO:0002673)	5.41	2	CR1, TNF
response to inorganic substance (GO:0010035)	3.56	2	HBB, ICAM1
oxidation-reduction process (GO:0055114)	2.91	2	NOS2, G6PD
cellular catabolic process (GO:0044248)	2.62	2	HBB, NOS2
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	CR1, FCGR2A
organonitrogen compound metabolic process (GO:1901564)	2.32	2	NOS2, G6PD
vesicle-mediated transport (GO:0016192)	2.72	2	HBB, CD36
regulation of removal of superoxide radicals (GO:2000121)	7.43	2	TNF, CD36
cell motility (GO:0048870)	3.02	2	TNF, ICAM1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	2	ICAM1, CD36
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	2	ICAM1, CD36
response to organonitrogen compound (GO:0010243)	3.2	2	TNF, ICAM1
positive regulation of organelle organization (GO:0010638)	3.38	2	TNF, ICAM1
response to nutrient levels (GO:0031667)	3.77	2	ICAM1, G6PD
regulation of leukocyte mediated cytotoxicity (GO:0001910)	5.78	2	NOS2, ICAM1
regulation of lipid storage (GO:0010883)	6.02	2	TNF, CD36
response to hormone (GO:0009725)	3.33	2	TNF, ICAM1
regulation of protein import (GO:1904589)	4.52	2	TNF, CD36
regulation of leukocyte mediated immunity (GO:0002703)	4.7	2	CR1, TNF
catabolic process (GO:0009056)	2.38	2	HBB, NOS2
regulation of catabolic process (GO:0009894)	3.52	2	TNF, NOS2
negative regulation of catabolic process (GO:0009895)	4.81	2	TNF, NOS2
negative regulation of biosynthetic process (GO:0009890)	2.47	2	TNF, CD36
regulation of lymphocyte proliferation (GO:0050670)	4.46	2	ICAM1, TIRAP
lipid storage (GO:0019915)	6.4	2	TNF, CD36
antigen processing and presentation (GO:0019882)	4.36	2	ICAM1, CD36
movement of cell or subcellular component (GO:0006928)	2.61	2	TNF, ICAM1
regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	7.43	2	CR1, TNF
regulation of cell killing (GO:0031341)	5.6	2	NOS2, ICAM1
secretion by cell (GO:0032940)	3.59	2	NOS2, CD36
regulation of humoral immune response (GO:0002920)	5.82	2	CR1, TNF
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	5.67	2	TIRAP, CD36
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	5.1	2	TIRAP, CD36
regulation of JNK cascade (GO:0046328)	4.65	2	TNF, TIRAP
positive regulation of cytokine biosynthetic process (GO:0042108)	5.65	2	TNF, TIRAP
negative regulation of protein transport (GO:0051224)	4.44	2	TNF, CD36
response to cytokine (GO:0034097)	3.84	2	NOS2, ICAM1
organic substance biosynthetic process (GO:1901576)	1.34	2	TNF, G6PD
regulation of protein secretion (GO:0050708)	3.77	2	TNF, NOS2
negative regulation of hydrolase activity (GO:0051346)	3.74	2	TNF, CR1
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	CR1, FCGR2A
regulation of kinase activity (GO:0043549)	3.07	2	TNF, CISH
inflammatory response to antigenic stimulus (GO:0002437)	6.51	2	TNF, ICAM1
macromolecular complex assembly (GO:0065003)	2.55	2	TNF, HBB
regulation of peptide secretion (GO:0002791)	4.38	2	TNF, NOS2
negative regulation of immune system process (GO:0002683)	3.85	2	TNF, CR1
cell migration (GO:0016477)	3.12	2	TNF, ICAM1
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	ACKR1, CISH
positive regulation of tumor necrosis factor production (GO:0032760)	5.7	2	TIRAP, CD36
lipid metabolic process (GO:0006629)	2.68	2	CD36, G6PD
protein secretion (GO:0009306)	4.97	2	NOS2, CD36
myeloid cell differentiation (GO:0030099)	4.63	2	TNF, TIRAP
hexose metabolic process (GO:0019318)	4.64	2	TNF, G6PD
regulation of insulin secretion (GO:0050796)	4.57	2	TNF, NOS2
regulation of mononuclear cell proliferation (GO:0032944)	4.45	2	ICAM1, TIRAP
regulation of immunoglobulin mediated immune response (GO:0002889)	6.04	2	CR1, TNF
positive regulation of blood circulation (GO:1903524)	5.16	2	NOS2, ICAM1
coagulation (GO:0050817)	4.51	2	HBB, CD36
regulation of blood circulation (GO:1903522)	4.05	2	NOS2, ICAM1
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	TNF, G6PD
regulation of protein import into nucleus (GO:0042306)	4.54	2	TNF, CD36
cellular nitrogen compound metabolic process (GO:0034641)	1.22	2	NOS2, G6PD
humoral immune response (GO:0006959)	4.59	2	TNF, CR1
regulation of protein localization to nucleus (GO:1900180)	4.34	2	TNF, CD36
secretion (GO:0046903)	3.38	2	NOS2, CD36
endocytosis (GO:0006897)	3.69	2	HBB, CD36
cellular response to cytokine stimulus (GO:0071345)	4.33	2	NOS2, ICAM1
response to decreased oxygen levels (GO:0036293)	4.09	2	NOS2, ICAM1
response to nitrogen compound (GO:1901698)	3.12	2	TNF, ICAM1
cellular response to nitrogen compound (GO:1901699)	3.79	2	TNF, ICAM1
innate immune response-activating signal transduction (GO:0002758)	4.45	2	TIRAP, CD36
regulation of transferase activity (GO:0051338)	2.88	2	TNF, CISH
activation of innate immune response (GO:0002218)	4.41	2	TIRAP, CD36
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	TNF, TIRAP
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	TNF, CD36
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	2	TNF, CD36
response to alcohol (GO:0097305)	4.58	2	ICAM1, G6PD
negative regulation of immune effector process (GO:0002698)	5.1	2	TNF, CR1
positive regulation of response to external stimulus (GO:0032103)	4.17	2	TNF, TIRAP
regulation of organelle organization (GO:0033043)	2.72	2	TNF, ICAM1
ion homeostasis (GO:0050801)	3.42	2	CD36, SLC4A1
cell differentiation (GO:0030154)	2.14	2	TNF, TIRAP
regulation of blood microparticle formation (GO:2000332)	9.04	2	TNF, CD36
bicarbonate transport (GO:0015701)	5.97	2	HBB, SLC4A1
regulation of adaptive immune response (GO:0002819)	4.91	2	TNF, CR1
regulation of cellular protein localization (GO:1903827)	3.43	2	TNF, CD36
regulation of protein catabolic process (GO:0042176)	3.83	2	TNF, NOS2
cellular component assembly (GO:0022607)	2.14	2	TNF, HBB
regulation of secretion by cell (GO:1903530)	3.28	2	TNF, NOS2
regulation of protein targeting (GO:1903533)	4.0	2	TNF, CD36
negative regulation of establishment of protein localization (GO:1904950)	4.39	2	TNF, CD36
response to hypoxia (GO:0001666)	4.13	2	NOS2, ICAM1
positive regulation of phagocytosis (GO:0050766)	5.9	2	TNF, CD36
regulation of phagocytosis (GO:0050764)	5.49	2	TNF, CD36
regulation of lymphocyte activation (GO:0051249)	3.73	2	ICAM1, TIRAP
cellular response to bacterial lipoprotein (GO:0071220)	7.94	2	TIRAP, CD36
regulation of system process (GO:0044057)	3.53	2	NOS2, ICAM1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	TNF, CD36
regulation of endocytosis (GO:0030100)	4.42	2	TNF, CD36
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	TNF, CISH
regulation of cell activation (GO:0050865)	3.53	2	ICAM1, TIRAP
toll-like receptor signaling pathway (GO:0002224)	5.26	2	TIRAP, CD36
pattern recognition receptor signaling pathway (GO:0002221)	5.02	2	TIRAP, CD36
regulation of interleukin-8 production (GO:0032677)	5.62	2	TNF, TIRAP
positive regulation of cell proliferation (GO:0008284)	3.01	2	TNF, TIRAP
organelle organization (GO:0006996)	2.02	2	TNF, GYPA
regulation of body fluid levels (GO:0050878)	3.76	2	HBB, CD36
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	6.2	2	TIRAP, CD36
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	4.44	2	TNF, TIRAP
neurological system process (GO:0050877)	2.64	2	ICAM1, CD36
cellular ion homeostasis (GO:0006873)	3.57	2	CD36, SLC4A1
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	TNF, CD36
regulation of stress-activated MAPK cascade (GO:0032872)	4.45	2	TNF, TIRAP
regulation of cell differentiation (GO:0045595)	2.42	2	TNF, CD36
regulation of hormone secretion (GO:0046883)	4.18	2	TNF, NOS2
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	TNF, CD36
positive regulation of stress-activated MAPK cascade (GO:0032874)	4.82	2	TNF, TIRAP
cation homeostasis (GO:0055080)	3.46	2	CD36, SLC4A1
response to alkaloid (GO:0043279)	4.83	2	TNF, ICAM1
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	4.82	2	TNF, TIRAP
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	TNF, NOS2
negative regulation of immune response (GO:0050777)	4.94	2	CR1, TNF
regulation of cellular response to oxidative stress (GO:1900407)	5.72	2	TNF, CD36
regulation of peptide transport (GO:0090087)	4.37	2	TNF, NOS2
positive regulation of developmental process (GO:0051094)	2.77	2	TNF, CD36
monosaccharide metabolic process (GO:0005996)	4.57	2	TNF, G6PD
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	TNF, CD36
response to drug (GO:0042493)	3.71	2	NOS2, ICAM1
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	TNF, CD36
positive regulation of apoptotic process (GO:0043065)	3.38	2	TNF, ICAM1
nitric oxide mediated signal transduction (GO:0007263)	6.78	2	NOS2, CD36
regulation of response to reactive oxygen species (GO:1901031)	6.29	2	TNF, CD36
positive regulation of proteolysis (GO:0045862)	3.86	2	TNF, CR1
glucose metabolic process (GO:0006006)	4.94	2	TNF, G6PD
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	2	TNF, ICAM1
regulation of superoxide metabolic process (GO:0090322)	6.64	2	TNF, CD36
positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)	8.12	2	TNF, TIRAP
regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000341)	7.65	2	TNF, TIRAP
receptor-mediated endocytosis (GO:0006898)	4.31	2	HBB, CD36
cellular response to lipoteichoic acid (GO:0071223)	7.53	2	TIRAP, CD36
regulation of cellular localization (GO:0060341)	3.03	2	TNF, CD36
cellular response to bacterial lipopeptide (GO:0071221)	7.94	2	TIRAP, CD36
macromolecular complex subunit organization (GO:0043933)	2.14	2	TNF, HBB
nitrogen compound metabolic process (GO:0006807)	1.13	2	NOS2, G6PD
regulation of cell-cell adhesion (GO:0022407)	3.79	2	TNF, ICAM1
leukocyte migration (GO:0050900)	4.19	2	TNF, ICAM1
regulation of blood pressure (GO:0008217)	4.72	2	HBB, NOS2
cytokine secretion (GO:0050663)	6.07	2	NOS2, CD36
protein complex subunit organization (GO:0071822)	2.6	2	TNF, HBB
regulation of leukocyte activation (GO:0002694)	3.6	2	ICAM1, TIRAP
cellular response to organonitrogen compound (GO:0071417)	3.87	2	TNF, ICAM1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	TNF, CD36
cellular response to alkaloid (GO:0071312)	6.2	2	TNF, ICAM1
regulation of leukocyte proliferation (GO:0070663)	4.4	2	ICAM1, TIRAP
negative regulation of apoptotic process (GO:0043066)	3.04	2	TNF, ICAM1
response to bacterial lipoprotein (GO:0032493)	7.78	2	TIRAP, CD36
negative regulation of programmed cell death (GO:0043069)	3.02	2	TNF, ICAM1
positive regulation of programmed cell death (GO:0043068)	3.38	2	TNF, ICAM1
positive regulation of blood microparticle formation (GO:2000334)	9.04	2	TNF, CD36
positive regulation of innate immune response (GO:0045089)	4.22	2	TIRAP, CD36
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	TNF, CD36
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	TNF, CISH
regulation of endopeptidase activity (GO:0052548)	3.8	2	CR1, TNF
protein complex assembly (GO:0006461)	2.78	2	TNF, HBB
regulation of hormone levels (GO:0010817)	3.56	2	TNF, NOS2
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	TNF, CD36
response to ethanol (GO:0045471)	4.83	2	ICAM1, G6PD
regulation of B cell mediated immunity (GO:0002712)	6.02	2	CR1, TNF
leukocyte cell-cell adhesion (GO:0007159)	4.26	2	TNF, ICAM1
reactive oxygen species metabolic process (GO:0072593)	5.14	2	HBB, NOS2
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	TNF, CD36
single-organism organelle organization (GO:1902589)	2.68	2	TNF, GYPA
regulation of cytokine production involved in immune response (GO:0002718)	5.69	2	TNF, CD36
positive regulation of endopeptidase activity (GO:0010950)	4.78	2	TNF, CR1
cellular response to oxidative stress (GO:0034599)	4.7	2	CD36, G6PD
positive regulation of peptidase activity (GO:0010952)	4.7	2	TNF, CR1
regulation of response to oxidative stress (GO:1902882)	5.62	2	TNF, CD36
response to oxygen levels (GO:0070482)	4.02	2	NOS2, ICAM1
locomotion (GO:0040011)	2.91	2	TNF, ICAM1
positive regulation of cell differentiation (GO:0045597)	3.01	2	TNF, CD36
carbohydrate metabolic process (GO:0005975)	3.26	2	TNF, G6PD
positive regulation of immune effector process (GO:0002699)	4.69	2	TNF, CD36
regulation of peptide hormone secretion (GO:0090276)	4.41	2	TNF, NOS2
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	TNF, CD36
response to lipoteichoic acid (GO:0070391)	7.53	2	TIRAP, CD36
regulation of tumor necrosis factor production (GO:0032680)	5.13	2	TIRAP, CD36
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	TNF, G6PD
regulation of peptidase activity (GO:0052547)	3.75	2	TNF, CR1
phosphorus metabolic process (GO:0006793)	2.15	2	TNF, G6PD
positive regulation of endocytosis (GO:0045807)	4.98	2	TNF, CD36
receptor metabolic process (GO:0043112)	5.32	2	TNF, CD36
positive regulation of interleukin-8 production (GO:0032757)	5.92	2	TNF, TIRAP
cytoskeleton organization (GO:0007010)	3.22	2	TNF, GYPA
response to extracellular stimulus (GO:0009991)	3.71	2	ICAM1, G6PD

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)	-	8.12	0.017	TNF, TIRAP
regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000341)	-	7.65	0.009	TNF, TIRAP
response to bacterium (GO:0009617)	-	4.18	0.014	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
cellular response to lipopolysaccharide (GO:0071222)	-	4.94	0.001	TNF, NOS2, ICAM1, CD36
cellular response to lipoteichoic acid (GO:0071223)	-	7.53	0.012	TIRAP, CD36
cellular response to bacterial lipoprotein (GO:0071220)	-	7.94	0.025	TIRAP, CD36
cellular response to bacterial lipopeptide (GO:0071221)	-	7.94	0.006	TIRAP, CD36
response to stress (GO:0006950)	-	1.8	0.004	ACKR1, NOS2, G6PD, CD36, CR1, TIRAP, TNF, HBB, FCGR2A, ICAM1
toll-like receptor 2 signaling pathway (GO:0034134)	NEW	7.94	0.008	TNF, NOS2, TIRAP, CD36
response to bacterial lipopeptide (GO:0070339)	-	7.94	0.025	TIRAP, CD36
negative regulation of sequestering of calcium ion (GO:0051283)	NEW	6.04	0.043	TNF, NOS2, ICAM1
regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	-	7.43	0.039	CR1, TNF
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123)	NEW	8.63	0.006	TNF, NOS2, TIRAP, CD36
positive regulation of nitric oxide biosynthetic process (GO:0045429)	-	5.99	0.002	TNF, HBB, ICAM1
regulation of nitric oxide biosynthetic process (GO:0045428)	-	5.76	0.005	TNF, HBB, ICAM1
regulation of leukocyte mediated immunity (GO:0002703)	-	4.7	0.008	CR1, TNF, NOS2, ICAM1
defense response to bacterium (GO:0042742)	-	4.31	0.003	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124)	NEW	8.34	0.006	TNF, NOS2, TIRAP, CD36
response to lipopolysaccharide (GO:0032496)	-	4.03	0.001	TNF, NOS2, TIRAP, ICAM1, CD36
cellular response to chemical stimulus (GO:0070887)	-	2.57	0.032	ACKR1, NOS2, G6PD, CD36, HBB, TIRAP, TNF, ICAM1
positive regulation of cytokine production involved in immune response (GO:0002720)	NEW	6.33	0.048	TNF, ICAM1, CD36
negative regulation of growth of symbiont in host (GO:0044130)	-	7.02	0.0	TNF, ICAM1, TIRAP, CD36
response to bacterial lipoprotein (GO:0032493)	-	7.78	0.009	TIRAP, CD36
immune system process (GO:0002376)	-	2.29	0.023	NOS2, FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
defense response to Gram-positive bacterium (GO:0050830)	-	5.54	0.008	TNF, NOS2, TIRAP, CD36
response to lipoteichoic acid (GO:0070391)	-	7.53	0.012	TIRAP, CD36
positive regulation of neutrophil chemotaxis (GO:0090023)	NEW	6.59	0.012	TNF, ICAM1, TIRAP
regulation of neutrophil chemotaxis (GO:0090022)	NEW	6.43	0.035	TNF, ICAM1, TIRAP
regulation of chemokine production (GO:0032642)	-	5.54	0.01	TNF, ACKR1, TIRAP
release of sequestered calcium ion into cytosol (GO:0051209)	NEW	6.04	0.043	TNF, NOS2, ICAM1
positive regulation of leukocyte migration (GO:0002687)	-	5.05	0.026	TNF, ICAM1, TIRAP
positive regulation of immune system process (GO:0002684)	-	2.96	0.001	NOS2, CD36, FCGR2A, CR1, TIRAP, TNF, ICAM1
response to interleukin-6 (GO:0070741)	NEW	6.78	0.025	TNF, NOS2, ICAM1
regulation of immune system process (GO:0002682)	-	2.5	0.002	NOS2, FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
cellular response to molecule of bacterial origin (GO:0071219)	-	4.88	0.0	TNF, NOS2, TIRAP, ICAM1, CD36
toll-like receptor signaling pathway (GO:0002224)	-	5.26	0.002	TNF, NOS2, TIRAP, ICAM1, CD36
cellular response to biotic stimulus (GO:0071216)	-	4.76	0.019	TNF, NOS2, TIRAP, ICAM1, CD36
modulation of growth of symbiont involved in interaction with host (GO:0044144)	-	6.9	0.0	TNF, ICAM1, TIRAP, CD36
pattern recognition receptor signaling pathway (GO:0002221)	-	5.02	0.007	TNF, NOS2, TIRAP, ICAM1, CD36
positive regulation of granulocyte chemotaxis (GO:0071624)	NEW	6.47	0.021	TNF, ICAM1, TIRAP
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	-	4.54	0.018	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of neutrophil migration (GO:1902622)	NEW	6.23	0.037	TNF, ICAM1, TIRAP
regulation of interleukin-12 production (GO:0032655)	-	5.78	0.009	TNF, ICAM1, TIRAP, CD36
positive regulation of cellular extravasation (GO:0002693)	NEW	7.24	0.046	TNF, ICAM1
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	-	6.2	0.0	TNF, NOS2, TIRAP, ICAM1, CD36
defense response (GO:0006952)	-	2.78	0.023	ACKR1, NOS2, CD36, FCGR2A, CR1, TIRAP, TNF
response to ethanol (GO:0045471)	-	4.83	0.0	NOS2, G6PD, CD36, TIRAP, TNF, ICAM1
positive regulation of JNK cascade (GO:0046330)	-	4.98	0.026	TNF, NOS2, TIRAP, ICAM1
regulation of immune response (GO:0050776)	-	2.98	0.002	FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B, ICAM1
cellular response to oxygen-containing compound (GO:1901701)	-	3.22	0.008	NOS2, CD36, HBB, TIRAP, TNF, ICAM1
toll-like receptor 4 signaling pathway (GO:0034142)	NEW	6.84	0.001	TNF, NOS2, TIRAP, ICAM1, CD36
immune response (GO:0006955)	-	2.86	0.012	NOS2, FCGR2A, CD36, CR1, TIRAP, TNF, FCGR2B
regulation of acute inflammatory response (GO:0002673)	-	5.41	0.024	CR1, TNF, NOS2, ICAM1
acute inflammatory response (GO:0002526)	NEW	5.48	0.046	TNF, NOS2, ICAM1, CD36
cellular response to oxidative stress (GO:0034599)	-	4.7	0.039	TNF, HBB, NOS2, CD36, G6PD
regulation of growth of symbiont in host (GO:0044126)	-	6.96	0.0	TNF, ICAM1, TIRAP, CD36
response to other organism (GO:0051707)	-	3.48	0.001	ACKR1, NOS2, CD36, HBB, TIRAP, TNF, GYPA, ICAM1
negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	-	6.96	0.0	TNF, ICAM1, TIRAP, CD36
multi-organism process (GO:0051704)	-	2.65	0.021	NOS2, CD36, TIRAP, TNF, GYPA, FCGR2B, ICAM1
response to oxygen-containing compound (GO:1901700)	-	2.57	0.01	NOS2, G6PD, CD36, HBB, TIRAP, TNF, ICAM1
regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	NEW	6.68	0.009	TNF, NOS2, ICAM1
immune response-activating signal transduction (GO:0002757)	-	3.8	0.012	NOS2, CD36, FCGR2A, CR1, TIRAP, TNF, ICAM1
response to biotic stimulus (GO:0009607)	-	3.09	0.006	NOS2, CD36, TIRAP, TNF, GYPA, ICAM1
response to external biotic stimulus (GO:0043207)	-	3.13	0.005	NOS2, CD36, TIRAP, TNF, GYPA, ICAM1
response to external stimulus (GO:0009605)	-	2.55	0.027	NOS2, G6PD, CD36, TIRAP, TNF, GYPA, ICAM1
regulation of innate immune response (GO:0045088)	-	3.86	0.031	NOS2, CD36, CR1, TIRAP, TNF, ICAM1
innate immune response-activating signal transduction (GO:0002758)	-	4.45	0.008	TNF, NOS2, TIRAP, ICAM1, CD36
positive regulation of neutrophil migration (GO:1902624)	NEW	6.43	0.012	TNF, ICAM1, TIRAP
regulation of interleukin-6 production (GO:0032675)	-	5.08	0.004	TNF, NOS2, TIRAP, ICAM1, CD36
cytokine production (GO:0001816)	NEW	5.42	0.04	TNF, ICAM1, TIRAP, G6PD
activation of innate immune response (GO:0002218)	-	4.41	0.011	TNF, NOS2, TIRAP, ICAM1, CD36
regulation of immune effector process (GO:0002697)	-	3.71	0.003	TNF, CR1, NOS2, ICAM1, CD36
negative regulation of multi-organism process (GO:0043901)	-	4.7	0.01	TNF, ICAM1, TIRAP, FCGR2A, CD36
response to molecule of bacterial origin (GO:0002237)	-	3.99	0.001	TNF, NOS2, TIRAP, ICAM1, CD36
activation of immune response (GO:0002253)	-	3.67	0.028	NOS2, CD36, FCGR2A, CR1, TIRAP, TNF, ICAM1
positive regulation of interleukin-12 production (GO:0032735)	-	6.23	0.001	TNF, ICAM1, TIRAP, CD36
regulation of blood pressure (GO:0008217)	-	4.72	0.027	TNF, HBB, NOS2, ICAM1, CD36
cyclooxygenase pathway (GO:0019371)	NEW	7.33	0.003	TNF, HBB, ICAM1
positive regulation of interleukin-8 production (GO:0032757)	-	5.92	0.024	TNF, ICAM1, TIRAP
positive regulation of interleukin-6 production (GO:0032755)	-	5.51	0.002	TNF, NOS2, ICAM1, CD36
negative regulation of lipid storage (GO:0010888)	NEW	6.9	0.003	TNF, NOS2, ICAM1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	16	ACKR1, NOS2, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB, GYPC
membrane (GO:0016020)	0.68	15	ACKR1, GYPC, G6PD, CR1, CISH, SLC4A1, TIRAP, CD36, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB
membrane part (GO:0044425)	0.95	14	ACKR1, G6PD, GYPC, CD36, CR1, GYPB, SLC4A1, TIRAP, TNF, HBB, GYPA, FCGR2A, FCGR2B, ICAM1
organelle (GO:0043226)	0.4	13	ACKR1, NOS2, G6PD, CD36, CR1, TIRAP, TNF, HBB, GYPA, FCGR2A, SLC4A1, ICAM1, GYPC
plasma membrane (GO:0005886)	1.39	13	ACKR1, FCGR2A, CD36, CR1, CISH, SLC4A1, TIRAP, TNF, GYPA, FCGR2B, ICAM1, GYPB, GYPC
integral component of membrane (GO:0016021)	1.14	12	ACKR1, CD36, FCGR2A, CR1, GYPB, SLC4A1, TNF, HBB, GYPA, FCGR2B, ICAM1, GYPC
membrane-bounded organelle (GO:0043227)	0.47	12	ACKR1, NOS2, G6PD, CD36, CR1, TIRAP, TNF, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
intrinsic component of membrane (GO:0031224)	1.13	12	ACKR1, CD36, FCGR2A, CR1, GYPB, SLC4A1, TNF, HBB, GYPA, FCGR2B, ICAM1, GYPC
intracellular part (GO:0044424)	0.28	10	ACKR1, NOS2, G6PD, CD36, HBB, CISH, TIRAP, TNF, SLC4A1, GYPC
cytoplasmic part (GO:0044444)	0.82	10	ACKR1, NOS2, G6PD, CD36, HBB, CISH, TIRAP, TNF, SLC4A1, GYPC
plasma membrane part (GO:0044459)	1.95	10	G6PD, CD36, CR1, GYPB, TIRAP, TNF, GYPA, SLC4A1, ICAM1, GYPC
extracellular region part (GO:0044421)	1.57	10	G6PD, CD36, CR1, TIRAP, TNF, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
vesicle (GO:0031982)	1.64	9	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
membrane-bounded vesicle (GO:0031988)	1.71	9	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
intracellular organelle (GO:0043229)	0.51	8	ACKR1, NOS2, G6PD, CD36, TIRAP, TNF, SLC4A1, GYPC
intrinsic component of plasma membrane (GO:0031226)	2.53	8	GYPC, CD36, CR1, GYPB, TNF, GYPA, SLC4A1, ICAM1
integral component of plasma membrane (GO:0005887)	2.57	8	GYPC, CD36, CR1, GYPB, TNF, GYPA, SLC4A1, ICAM1
extracellular vesicle (GO:1903561)	1.89	7	FCGR2A, G6PD, CR1, HBB, GYPA, SLC4A1, ICAM1
extracellular organelle (GO:0043230)	1.89	7	FCGR2A, G6PD, CR1, HBB, GYPA, SLC4A1, ICAM1
extracellular exosome (GO:0070062)	1.89	7	FCGR2A, G6PD, CR1, HBB, GYPA, SLC4A1, ICAM1
cytosol (GO:0005829)	1.68	6	NOS2, G6PD, CD36, HBB, CISH, TIRAP
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	ACKR1, NOS2, G6PD, CD36, TIRAP, TNF
organelle part (GO:0044422)	0.79	5	HBB, TIRAP, SLC4A1, G6PD, CD36
side of membrane (GO:0098552)	4.22	5	TNF, GYPA, ICAM1, CD36, G6PD
cytoplasm (GO:0005737)	1.01	4	NOS2, TIRAP, CISH, G6PD
external side of plasma membrane (GO:0009897)	4.46	4	TNF, GYPA, ICAM1, CD36
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	4	NOS2, SLC4A1, G6PD, GYPC
cell surface (GO:0009986)	3.44	4	TNF, CR1, ICAM1, CD36
intracellular organelle part (GO:0044446)	0.81	4	HBB, TIRAP, CD36, G6PD
non-membrane-bounded organelle (GO:0043228)	1.76	4	NOS2, SLC4A1, G6PD, GYPC
cytoskeleton (GO:0005856)	2.55	3	NOS2, SLC4A1, GYPC
plasma membrane region (GO:0098590)	2.97	3	TIRAP, CD36, SLC4A1
membrane raft (GO:0045121)	4.18	3	TNF, ICAM1, CD36
extracellular space (GO:0005615)	2.63	3	TNF, ICAM1, CD36
cortical cytoskeleton (GO:0030863)	5.58	3	NOS2, SLC4A1, GYPC
membrane region (GO:0098589)	3.95	3	TNF, ICAM1, CD36
membrane microdomain (GO:0098857)	4.17	3	TNF, ICAM1, CD36
cell cortex part (GO:0044448)	5.01	3	NOS2, SLC4A1, GYPC
protein complex (GO:0043234)	1.51	2	HBB, CD36
endocytic vesicle (GO:0030139)	5.04	2	TIRAP, CD36
macromolecular complex (GO:0032991)	1.35	2	HBB, CD36
vacuole (GO:0005773)	2.92	2	TNF, ACKR1
cytoplasmic vesicle (GO:0031410)	2.87	2	TIRAP, CD36
recycling endosome (GO:0055037)	5.11	2	TNF, ACKR1
cell projection part (GO:0044463)	2.97	2	TIRAP, CD36
cell projection membrane (GO:0031253)	4.11	2	TIRAP, CD36
blood microparticle (GO:0072562)	4.88	2	HBB, SLC4A1
intracellular (GO:0005622)	2.37	2	TNF, NOS2
cytoplasmic vesicle part (GO:0044433)	3.41	2	HBB, CD36
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	TIRAP, CD36
extracellular region (GO:0005576)	2.18	2	TNF, HBB
intracellular vesicle (GO:0097708)	2.86	2	TIRAP, CD36
endosome (GO:0005768)	3.25	2	TNF, ACKR1
nucleus (GO:0005634)	1.07	2	NOS2, G6PD

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	-	4.46	0.001	TNF, GYPA, ICAM1, CD36
vesicle (GO:0031982)	-	1.64	0.036	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
cortical cytoskeleton (GO:0030863)	-	5.58	0.001	NOS2, ICAM1, SLC4A1, GYPC
membrane (GO:0016020)	-	0.68	0.005	ACKR1, CD36, G6PD, CR1, CISH, SLC4A1, TIRAP, TNF, GYPA, FCGR2A, FCGR2B, ICAM1, GYPB, GYPC
membrane-bounded vesicle (GO:0031988)	-	1.71	0.028	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
immunological synapse (GO:0001772)	NEW	6.31	0.006	TNF, ICAM1, FCGR2A
integral component of plasma membrane (GO:0005887)	-	2.57	0.013	NOS2, GYPC, CD36, CR1, GYPB, TIRAP, TNF, GYPA, SLC4A1, ICAM1
side of membrane (GO:0098552)	-	4.22	0.0	TNF, GYPA, ICAM1, CD36, G6PD
membrane part (GO:0044425)	-	0.95	0.022	ACKR1, CD36, G6PD, CR1, GYPB, SLC4A1, TIRAP, TNF, GYPA, FCGR2A, FCGR2B, ICAM1, GYPC
plasma membrane (GO:0005886)	-	1.39	0.0	ACKR1, FCGR2A, CD36, CR1, CISH, SLC4A1, TIRAP, TNF, GYPA, FCGR2B, ICAM1, GYPB, GYPC
plasma membrane part (GO:0044459)	-	1.95	0.007	ACKR1, NOS2, G6PD, CD36, CR1, GYPB, TIRAP, TNF, GYPA, FCGR2A, SLC4A1, ICAM1, GYPC
cell cortex part (GO:0044448)	-	5.01	0.008	NOS2, SLC4A1, GYPC