Disease table of MALARIA, SUSCEPTIBILITY TO OMIM ID: 611162

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Relations among genes:

Tandem repeat annotations from DGD

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Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 78	2	FCGR2B, FCGR2A

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Cytogenetic band analysis

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Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
1q23.3	2	FCGR2B, FCGR2A
4q31.21	2	GYPB, GYPA

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By band

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Shared band	Number of genes associated with the disease	Genes associated with the disease
1q23	3	FCGR2B, FCGR2A, ACKR1
4q31	2	GYPB, GYPA

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By region

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Shared region	Number of genes associated with the disease	Genes associated with the disease
1q2	3	FCGR2B, FCGR2A, ACKR1
4q3	2	GYPB, GYPA

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By arm

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Shared arm	Number of genes associated with the disease	Genes associated with the disease
17q	2	SLC4A1, NOS2
1q	4	FCGR2B, FCGR2A, ACKR1, CR1
4q	2	GYPB, GYPA

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By chromosome

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Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
1	4	FCGR2B, FCGR2A, ACKR1, CR1
4	2	GYPB, GYPA
11	2	TIRAP, HBB
17	2	SLC4A1, NOS2

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Transcription Factors (TF) annotation from TRRUST

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TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	NOS2, FCGR2B
NFKBIA	NO	19	EBI3, CXCL8, NOS2, TRAF1, CCL5, CD58, TNFSF10, NFKB1, RELA, S100A6, MMP3, FAS, MMP9, IL1B, MMP1, IFNB1, CD40, ICAM1, PON2	2	NOS2, ICAM1
CEBPB	NO	60	GADD45G, BCL2L1, IRF4, GOT1, PRL, DDIT3, CDKN1A, SMAD4, S100A9, SAA2, PTPN13, MMP1, F8, IL5RA, TFF3, ADM, CYP19A1, INSR, SFTPD, IL6, STAR, TNF, SMAD3, PCK2, IL1B, GNLY, FURIN, SAA1, SLC19A1, PTGS2, XBP1, HSF1, PRDM1, TNFAIP6, HP, IL24, IL10, SLC10A1, DAPK1, CSH2, OXTR, IL13, MAD1L1, CRP, CXCL8, SLC5A8, CSH1, HBB, ASNS, ALB, CSF3R, IL5, IL3, PRSS50, ABCB1, TOP1, GFER, IL4, CSRP1, FASLG	2	TNF, HBB
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	CISH, ICAM1
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	NOS2, ICAM1
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	TNF, NOS2
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	CR1, ICAM1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	TNF, NOS2, ICAM1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	TNF, NOS2, ICAM1
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	2	TNF, ICAM1

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regulated gene	associated to this disease	# TFs	TFs
NOS2	YES	16	APC, XBP1, STAT2, RELA, MTA1, NFKB1, YY1, FOSL2, IKBKB, NFKBIA, JUN, KLF6, JUND, FOS, KLF5, STAT1
CR1	YES	1	ETS1
G6PD	YES	1	CREM
FCGR2B	YES	2	YY1, GATA4
CD36	YES	3	RUNX3, PPARA, PPARG
TNF	YES	21	SP1, HMGB2, ETV4, NFAT5, SPI1, HSF1, HDAC11, RELA, JUN, IRF5, EGR1, CEBPB, HDAC3, NR4A1, ATF2, AR, LRRFIP1, CEBPD, E2F1, NFKB1, SIRT1
CISH	YES	2	STAT3, STAT6
ICAM1	YES	23	ETS2, MYB, REL, STAT1, TWIST1, RARG, SP1, CEBPA, ETV5, ERG, IFI16, SIRT1, TWIST2, HDAC1, RARA, SP100, NFATC1, RELA, NFKB1, ETS1, STAT3, NFKBIA, PPARG
HBB	YES	9	NFYB, CEBPG, KLF1, NFYA, NFYC, CEBPB, NFE2L2, GATA1, POU2F2
GYPA	YES	1	LMO2

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Interactions from BIOGRID - physical

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Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NOS2	ICAM1	Yes	17	TUBB6, HNRNPA1, SNRPD3, RPL5, RPL31, CCT3, RPS18, NOS2, SNRPB, RPS4X, RPS3A, NPM1, RPS3, YBX1, CCT4, DDX3X, XRCC5
FCGR2B	FCGR2A	Yes	1	PTPN11
NOS2	G6PD	No	8	HSPA9, YWHAE, SLC9A3R1, YWHAG, HSPB1, CCT4, YWHAQ, YWHAZ
NOS2	FCGR2A	No	1	TRIM21
NOS2	TNF	No	3	HSPB1, CAV1, YWHAQ
NOS2	CISH	No	4	TCEB2, CUL5, HSPA6, TCEB1
NOS2	HBB	No	1	UCHL5
TIRAP	CD36	No	1	APP
TIRAP	TNF	No	4	TNFSF9, TAB1, MAP3K7, TAB2
TIRAP	CISH	No	1	MYD88

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Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

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Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NOS2	TIRAP	No	-	2	UBC, TLR4
NOS2	CD36	No	-	5	SRC, MAPK14, PPARA, TLR4, IL4
NOS2	FCGR2A	No	-	4	SRC, UBC, RAC1, TLR4
NOS2	CISH	No	-	3	TYK2, STAT6, JAK2
NOS2	ICAM1	No	-	9	RAC1, IL4, IL18, UBC, JUN, RELA, SRC, PPARA, TLR4
CR1	ICAM1	No	-	1	IL8
TIRAP	CD36	No	-	3	CD14, TLR2, TLR4
TIRAP	FCGR2A	No	-	2	UBC, TLR4
TIRAP	CISH	No	-	0
TIRAP	ICAM1	No	-	5	UBC, IL6, HMGB1, TLR2, TLR4

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Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

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KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
African trypanosomiasis	hsa05143	7.68	3	TNF, HBB, ICAM1
Malaria	hsa05144	7.15	9	ACKR1, CD36, CR1, GYPB, TNF, HBB, GYPA, GYPC, ICAM1
Legionellosis	hsa05134	6.88	2	CR1, TNF
Staphylococcus aureus infection	hsa05150	6.64	3	ICAM1, FCGR2A, FCGR2B
Adipocytokine signaling pathway	hsa04920	6.6	2	TNF, CD36
Pertussis	hsa05133	6.46	3	TNF, NOS2, TIRAP
Leishmaniasis	hsa05140	6.32	4	TNF, CR1, NOS2, FCGR2A
NF-kappa B signaling pathway	hsa04064	6.21	3	TNF, ICAM1, TIRAP
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	FCGR2A, FCGR2B
Hematopoietic cell lineage	hsa04640	6.18	4	TNF, CR1, GYPA, CD36

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
African trypanosomiasis (hsa05143)	-	7.68	0.031	TNF, HBB, ICAM1
Malaria (hsa05144)	-	7.15	0.0	ACKR1, NOS2, CD36, CR1, GYPB, TNF, HBB, GYPA, GYPC, ICAM1
Staphylococcus aureus infection (hsa05150)	-	6.64	0.012	TNF, ICAM1, FCGR2A, FCGR2B
Pertussis (hsa05133)	-	6.46	0.002	TNF, NOS2, TIRAP, ICAM1, CD36
Leishmaniasis (hsa05140)	-	6.32	0.0	NOS2, FCGR2A, CR1, TNF, FCGR2B, ICAM1
Hematopoietic cell lineage (hsa04640)	-	6.18	0.004	TNF, CR1, GYPA, ICAM1, CD36
Toxoplasmosis (hsa05145)	-	5.71	0.013	TNF, NOS2, TIRAP, ICAM1, CD36
Hepatitis C (hsa05160)	NEW	5.68	0.013	TNF, CR1, NOS2, ICAM1, CD36
Osteoclast differentiation (hsa04380)	-	5.64	0.02	TNF, NOS2, FCGR2A, ICAM1, FCGR2B
Tuberculosis (hsa05152)	-	5.17	0.0	NOS2, FCGR2A, CR1, TIRAP, TNF, FCGR2B, ICAM1

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REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

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REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Erythrocytes take up oxygen and release carbon dioxide	R-HSA-1247673	9.98	2	HBB, SLC4A1
O2/CO2 exchange in erythrocytes	R-HSA-1480926	9.98	2	HBB, SLC4A1
Erythrocytes take up carbon dioxide and release oxygen	R-HSA-1237044	9.98	2	HBB, SLC4A1
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.52	2	TIRAP, CD36
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.52	2	TIRAP, CD36
Diseases of Immune System	R-HSA-5260271	8.34	2	TIRAP, CD36
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.34	2	TIRAP, CD36
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7	2	TNF, CD36
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	TIRAP, CD36
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	TIRAP, CD36

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
O2/CO2 exchange in erythrocytes (R-HSA-1480926)	-	9.98	0.005	HBB, SLC4A1
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673)	-	9.98	0.005	HBB, SLC4A1
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044)	-	9.98	0.005	HBB, SLC4A1
MyD88 deficiency (TLR2/4) (R-HSA-5602498)	-	9.52	0.01	TIRAP, CD36
IRAK4 deficiency (TLR2/4) (R-HSA-5603041)	-	9.52	0.01	TIRAP, CD36
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (R-HSA-2162123)	NEW	9.18	0.001	TNF, HBB, ICAM1
Diseases of Immune System (R-HSA-5260271)	-	8.34	0.0	TNF, ICAM1, TIRAP, CD36
Diseases associated with the TLR signaling cascade (R-HSA-5602358)	-	8.34	0.0	TNF, ICAM1, TIRAP, CD36
Toll Like Receptor TLR6:TLR2 Cascade (R-HSA-168188)	-	6.56	0.011	TNF, NOS2, TIRAP, CD36
MyD88:Mal cascade initiated on plasma membrane (R-HSA-166058)	-	6.56	0.011	TNF, NOS2, TIRAP, CD36

Showing 1 to 10 of 15 entries

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
IgG binding (GO:0019864)	7.34	2	FCGR2A, FCGR2B
immunoglobulin binding (GO:0019865)	6.6	2	FCGR2A, FCGR2B
NADP binding (GO:0050661)	5.93	2	NOS2, G6PD
virus receptor activity (GO:0001618)	5.49	3	CR1, GYPA, ICAM1
cytokine binding (GO:0019955)	5.21	2	ACKR1, CD36
heme binding (GO:0020037)	4.86	2	HBB, NOS2
tetrapyrrole binding (GO:0046906)	4.8	2	HBB, NOS2
coenzyme binding (GO:0050662)	4.53	2	NOS2, G6PD
carbohydrate binding (GO:0030246)	4.17	2	G6PD, GYPC
cofactor binding (GO:0048037)	4.16	2	NOS2, G6PD

Showing 1 to 10 of 38 entries

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
IgG binding (GO:0019864)	-	7.34	0.004	TNF, FCGR2A, FCGR2B
immunoglobulin binding (GO:0019865)	-	6.6	0.016	TNF, FCGR2A, FCGR2B
NADP binding (GO:0050661)	-	5.93	0.025	TNF, NOS2, G6PD
virus receptor activity (GO:0001618)	-	5.49	0.029	GYPA, ICAM1
cytokine binding (GO:0019955)	-	5.21	0.01	TNF, ACKR1, NOS2, CD36
growth factor receptor binding (GO:0070851)	NEW	4.87	0.031	TNF, NOS2, ICAM1, CD36
heme binding (GO:0020037)	-	4.86	0.04	TNF, HBB, NOS2, ICAM1
heparin binding (GO:0008201)	NEW	4.68	0.012	TNF, NOS2, ICAM1, CD36, FCGR2B
cytokine receptor binding (GO:0005126)	NEW	4.14	0.003	NOS2, CD36, CISH, TIRAP, TNF, ICAM1
protein homodimerization activity (GO:0042803)	-	3.16	0.017	GYPA, SLC4A1, TIRAP, NOS2, G6PD

Showing 1 to 10 of 13 entries

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
regulation of blood microparticle formation (GO:2000332)	9.04	2	TNF, CD36
positive regulation of blood microparticle formation (GO:2000334)	9.04	2	TNF, CD36
positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)	8.12	2	TNF, TIRAP
response to bacterial lipopeptide (GO:0070339)	7.94	2	TIRAP, CD36
cellular response to bacterial lipoprotein (GO:0071220)	7.94	2	TIRAP, CD36
cellular response to bacterial lipopeptide (GO:0071221)	7.94	2	TIRAP, CD36
response to bacterial lipoprotein (GO:0032493)	7.78	2	TIRAP, CD36
regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000341)	7.65	2	TNF, TIRAP
cellular response to lipoteichoic acid (GO:0071223)	7.53	2	TIRAP, CD36
response to lipoteichoic acid (GO:0070391)	7.53	2	TIRAP, CD36

Showing 1 to 10 of 485 entries

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123)	NEW	8.63	0.006	TNF, NOS2, TIRAP, CD36
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124)	NEW	8.34	0.006	TNF, NOS2, TIRAP, CD36
positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)	-	8.12	0.017	TNF, TIRAP
cellular response to bacterial lipoprotein (GO:0071220)	-	7.94	0.025	TIRAP, CD36
cellular response to bacterial lipopeptide (GO:0071221)	-	7.94	0.006	TIRAP, CD36
toll-like receptor 2 signaling pathway (GO:0034134)	NEW	7.94	0.008	TNF, NOS2, TIRAP, CD36
response to bacterial lipopeptide (GO:0070339)	-	7.94	0.025	TIRAP, CD36
response to bacterial lipoprotein (GO:0032493)	-	7.78	0.009	TIRAP, CD36
regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000341)	-	7.65	0.009	TNF, TIRAP
cellular response to lipoteichoic acid (GO:0071223)	-	7.53	0.012	TIRAP, CD36

Showing 1 to 10 of 81 entries

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GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
cortical cytoskeleton (GO:0030863)	5.58	3	NOS2, SLC4A1, GYPC
recycling endosome (GO:0055037)	5.11	2	TNF, ACKR1
endocytic vesicle (GO:0030139)	5.04	2	TIRAP, CD36
cell cortex part (GO:0044448)	5.01	3	NOS2, SLC4A1, GYPC
blood microparticle (GO:0072562)	4.88	2	HBB, SLC4A1
external side of plasma membrane (GO:0009897)	4.46	4	TNF, GYPA, ICAM1, CD36
side of membrane (GO:0098552)	4.22	5	TNF, GYPA, ICAM1, CD36, G6PD
membrane raft (GO:0045121)	4.18	3	TNF, ICAM1, CD36
membrane microdomain (GO:0098857)	4.17	3	TNF, ICAM1, CD36
cell projection membrane (GO:0031253)	4.11	2	TIRAP, CD36

Showing 1 to 10 of 54 entries

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
immunological synapse (GO:0001772)	NEW	6.31	0.006	TNF, ICAM1, FCGR2A
cortical cytoskeleton (GO:0030863)	-	5.58	0.001	NOS2, ICAM1, SLC4A1, GYPC
cell cortex part (GO:0044448)	-	5.01	0.008	NOS2, SLC4A1, GYPC
external side of plasma membrane (GO:0009897)	-	4.46	0.001	TNF, GYPA, ICAM1, CD36
side of membrane (GO:0098552)	-	4.22	0.0	TNF, GYPA, ICAM1, CD36, G6PD
integral component of plasma membrane (GO:0005887)	-	2.57	0.013	NOS2, GYPC, CD36, CR1, GYPB, TIRAP, TNF, GYPA, SLC4A1, ICAM1
plasma membrane part (GO:0044459)	-	1.95	0.007	ACKR1, NOS2, G6PD, CD36, CR1, GYPB, TIRAP, TNF, GYPA, FCGR2A, SLC4A1, ICAM1, GYPC
membrane-bounded vesicle (GO:0031988)	-	1.71	0.028	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
vesicle (GO:0031982)	-	1.64	0.036	G6PD, CD36, CR1, TIRAP, HBB, GYPA, FCGR2A, SLC4A1, ICAM1
plasma membrane (GO:0005886)	-	1.39	0.0	ACKR1, FCGR2A, CD36, CR1, CISH, SLC4A1, TIRAP, TNF, GYPA, FCGR2B, ICAM1, GYPB, GYPC

Showing 1 to 10 of 12 entries