| Disease ID | Disease name | Source of annotation with P2RY12 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS231200 | BLEEDING DISORDER, PLATELET-TYPE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 21 | NBEAL2, ANO6, GP1BA, ITGA2, GFI1B, ITGA2B, PLAU, PRKACG, P2RY12, ACTN1, TBXAS1, P2RX1, GP6, CD36, SLFN14, ITGB3, GP9, GP1BB, RASGRP2, TBXA2R, MYH9 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Platelet activation | hsa04611 | 5.66 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Nucleotide-like (purinergic) receptors | R-HSA-418038 | 8.98 |
| ADP signalling through P2Y purinoceptor 12 | R-HSA-392170 | 8.52 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| G alpha (i) signalling events | R-HSA-418594 | 5.1 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Signal amplification | R-HSA-392518 | 7.98 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| P2Y receptors | R-HSA-417957 | 9.4 |
| GO term | GO ID | GO IC |
|---|---|---|
| purinergic nucleotide receptor activity | GO:0001614 | 6.69 |
| ADP receptor activity | GO:0001621 | 9.74 |
| G-protein coupled receptor activity | GO:0004930 | 2.95 |
| signaling receptor activity | GO:0038023 | 2.49 |
| molecular transducer activity | GO:0060089 | 2.32 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| G-protein coupled adenosine receptor activity | GO:0001609 | 7.79 |
| purinergic receptor activity | GO:0035586 | 6.52 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| G-protein coupled nucleotide receptor activity | GO:0001608 | 7.1 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| G-protein coupled purinergic nucleotide receptor activity | GO:0045028 | 7.1 |
| nucleotide receptor activity | GO:0016502 | 6.69 |
| molecular function regulator | GO:0098772 | 2.51 |
| transmembrane receptor activity | GO:0099600 | 2.53 |