Disease table of BLEEDING DISORDER, PLATELET-TYPE OMIM ID: PS231200

Gene-disease associations table

Gene	Associated with BLEEDING DISORDER, PLATELET-TYPE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
RASGRP2	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.1	1	PS231200
TBXA2R	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.3	1	PS231200
ACTN1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.1	1	PS231200
GFI1B	ClinVar, OMIM	HGNC link	9q34.13	1	PS231200
TBXAS1	OMIM	HGNC link	7q34	2	231095, PS231200
SLFN14	ClinVar, OMIM	HGNC link	17q12	1	PS231200
ITGA2B	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.31	1	PS231200
ANO6	ClinVar, OMIM	HGNC link	12q12	1	PS231200
MYH9	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.3	6	153650, 153640, PS124900, 600208, PS231200, 605249
GP1BA	ClinVar, OMIM, HUMSAVAR	HGNC link	17p13.2	3	PS231200, 258660, 153670
ITGB3	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.32	2	608446, PS231200
PLAU	ClinVar, OMIM	HGNC link	10q22.2	3	PS231200, PS142623, 104300
GP1BB	OMIM, HUMSAVAR	HGNC link	22q11.21	1	PS231200
CD36	ClinVar, OMIM, HUMSAVAR	HGNC link	7q21.11	3	PS231200, 610938, 611162
PRKACG	ClinVar, OMIM, HUMSAVAR	HGNC link	9q21.11	1	PS231200
P2RY12	ClinVar, OMIM, HUMSAVAR	HGNC link	3q25.1	1	PS231200
GP9	ClinVar, OMIM, HUMSAVAR	HGNC link	3q21.3	1	PS231200
P2RX1	OMIM	HGNC link	17p13.2	1	PS231200
GP6	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	1	PS231200
ITGA2	OMIM	HGNC link	5q11.2	1	PS231200
NBEAL2	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS231200

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
17p13.2	2	P2RX1, GP1BA

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
17p13	2	P2RX1, GP1BA
17q21	2	ITGA2B, ITGB3

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	2	ITGA2B, ITGB3
17p1	2	P2RX1, GP1BA
3q2	2	P2RY12, GP9
22q1	2	GP1BB, MYH9

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3q	2	P2RY12, GP9
22q	2	GP1BB, MYH9
7q	2	CD36, TBXAS1
9q	2	GFI1B, PRKACG
17q	3	ITGA2B, ITGB3, SLFN14
17p	2	P2RX1, GP1BA

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	5	ITGA2B, GP1BA, SLFN14, P2RX1, ITGB3
19	2	GP6, TBXA2R
22	2	GP1BB, MYH9
3	3	NBEAL2, P2RY12, GP9
7	2	CD36, TBXAS1
9	2	GFI1B, PRKACG

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
GFI1B	YES	1	MEF2C	0
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	TBXA2R, PLAU
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	5	TBXAS1, TBXA2R, PLAU, ITGB3, GP6
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	TBXA2R, PLAU, ITGB3, ITGA2
FLI1	NO	18	ID2, PHLDA1, TERT, FOXM1, GP9, MMP1, FLI1, MPL, EZH2, TGFBR2, ERG, IGFBP3, GATA1, IL10, HMOX1, CTGF, GP6, ITGA2B	3	GP9, GP6, ITGA2B
HOXD3	NO	5	ITGA5, ITGAV, PLAU, ITGB3, ITGB1	2	ITGB3, PLAU
GATA1	NO	52	PF4, PBXIP1, CBFB, GP1BA, GP9, KLF1, FCER1A, ITGA2B, EPO, SEMG1, TBXA2R, BACE1, DACH1, PTGFR, GP6, HBA2, DPYSL2, GYPB, TAL1, CYBB, COPS5, DICER1, CDA, FURIN, GNAS, WT1, ZNF268, BDKRB1, SPI1, GP1BB, NFE2, F13A1, GFI1B, MPL, AGGF1, CCR3, GATA1, IFNG, HEMGN, HBE1, BACH1, PPOX, CEBPA, CDC6, HBB, PRG2, FLI1, EPOR, IL1RL1, SMAD1, HBG1, HBA1	7	GFI1B, GP1BA, GP9, GP1BB, ITGA2B, TBXA2R, GP6
RUNX1	NO	36	PF4, GP1BA, ITGA2B, MAD2L1, LGALS3, NCAM1, CCND2, BPI, SLC22A4, CSF1, MECOM, CCL3, BAALC, CSF2, SPI1, IL2, CD34, MYL9, ITGB2, CSF1R, TIMP1, VEGFA, MYH10, FHL2, MPO, KLK3, NF1, IL3, SYMPK, JUN, ELANE, PRKCQ, MPL, PIK3CD, KLF4, CD6	2	GP1BA, ITGA2B
POU2F1	NO	38	AR, PLAU, TWIST1, MAD2L1, POU2AF1, UGT2B7, TRA, CAPN6, HIST2H2BE, IL2RA, IL4, CCND1, VCAM1, GCM1, PTGIR, ID1, HPGDS, TK1, IL5, LGALS4, BDKRB1, SNAPC1, IL2, SPP1, TXNRD1, GATA1, LCT, VWF, ST6GAL1, SNAI2, GFI1B, HBG1, GNRH1, RPTOR, GADD45A, SDC4, CDX2, RRM2B	2	GFI1B, PLAU

regulated gene	associated to this disease	# TFs	TFs
TBXA2R	YES	6	WT1, SP1, EGR1, NFE2, GATA1, ETS1
GFI1B	YES	6	NFYB, POU2F1, NFYA, NFYC, HMGB2, GATA1
TBXAS1	YES	3	EP300, ETS1, TP53
ITGA2B	YES	5	GATA1, STAT6, RUNX1, FLI1, SPI1
MYH9	YES	2	USF1, USF2
GP1BA	YES	2	GATA1, RUNX1
ITGB3	YES	6	SP1, HOXA10, HOXD3, FOSL1, JUND, ETS1
PLAU	YES	19	SP1, HIF1A, GATA6, RUNX2, EGR1, NFKB1, ATF4, HOXD3, ILF3, SRF, JUN, CREB1, ATF2, RARA, RFWD2, POU2F1, RELA, FOS, ETS1
GP1BB	YES	1	GATA1
CD36	YES	3	RUNX3, PPARA, PPARG
GP9	YES	2	GATA1, FLI1
GP6	YES	3	GATA1, FLI1, ETS1
ITGA2	YES	2	SP1, SP3

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
RASGRP2	CD36	No	1	APP
TBXA2R	ACTN1	No	1	PKN1
TBXA2R	ITGA2B	No	1	PRKACA
TBXA2R	MYH9	No	7	GNAI2, PSME3, RAB11A, GRK5, YWHAZ, ARRB2, GNAS
TBXA2R	GP1BA	No	1	YWHAZ
TBXA2R	GP1BB	No	1	YWHAZ
TBXA2R	PRKACG	No	1	PRKACA
TBXA2R	NBEAL2	No	1	YWHAZ
ACTN1	GFI1B	Yes	2	ATXN2, ACTN1
ACTN1	ITGA2B	No	1	CAMK2A
ACTN1	MYH9	Yes	32	TPM1, HSP90AB1, CALD1, ANLN, TERF1, SVIL, MYO19, MCM5, ISG15, ACTN4, TPM2, IQGAP1, PALLD, MCM2, SIRT7, DBN1, SORBS2, ACTN1, TERF2, PPP1CB, HSP90AA1, MYO1C, CDK2, TRAF3IP1, PDLIM7, TPM3, CAPZA2, ESR1, NTRK1, TPM4, CBL, SYNPO
ACTN1	PLAU	No	1	BTK
ACTN1	CD36	No	2	HSPB2, ITGB1
ACTN1	P2RY12	No	1	ECSIT
ACTN1	ITGA2	No	2	ATF2, ITGB1
GFI1B	MYH9	No	3	MYH14, ACTN1, LZTS2
ITGA2B	MYH9	No	1	GRB2
ITGA2B	ITGB3	No	1	CD36
ITGA2B	CD36	Yes	0
ITGA2B	PRKACG	No	1	PRKACA
ITGA2B	ITGA2	No	1	AUP1
ANO6	PLAU	No	1	ELAVL1
ANO6	ITGA2	No	1	LGALS8
MYH9	GP1BA	No	3	FLNA, FLNB, YWHAZ
MYH9	ITGB3	No	2	FLNA, FLNB
MYH9	GP1BB	No	3	LYN, TRAF4, YWHAZ
MYH9	CD36	No	3	LYN, FYN, YES1
MYH9	P2RY12	No	3	APOB, RNF170, ITPR2
MYH9	GP6	No	4	FYN, CALM1, LYN, TRAF4
MYH9	NBEAL2	No	1	YWHAZ
GP1BA	ITGB3	No	2	FLNA, FLNB
GP1BA	GP1BB	No	1	YWHAZ
GP1BA	NBEAL2	No	1	YWHAZ
ITGB3	GP1BB	No	1	PTK2B
ITGB3	CD36	Yes	0
ITGB3	GP6	No	1	PTK2B
GP1BB	CD36	No	1	LYN
GP1BB	GP6	No	5	TGFB1I1, PTK2B, LYN, TRAF4, NCF1
GP1BB	ITGA2	No	1	ZACN
GP1BB	NBEAL2	No	1	YWHAZ
CD36	GP6	No	2	LYN, FYN
CD36	ITGA2	No	1	ITGB1
P2RY12	ITGA2	No	1	LGALS3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TBXA2R	ACTN1	No	-	4	RAC1, KNG1, RHOA, APP
TBXA2R	ITGA2B	No	-	2	GNA13, SYK
TBXA2R	MYH9	No	-	3	RHOA, RAC1, RAB11A
TBXA2R	ITGB3	No	-	2	SYK, RHOA
TBXA2R	CD36	No	-	2	PTAFR, EDN1
TBXA2R	PRKACG	No	-	9	GNB5, GNG2, RHOA, KCNMA1, SLC9A3R1, EDN1, PRKCE, AGT, GNB1
TBXA2R	P2RY12	No	-	25	GNG2, LPAR5, GPR17, AGT, BDKRB2, KNG1, LPAR3, CASR, APP, ANXA1, GNB1, MCHR2, NMUR1, LPAR2, SLC9A3R1, NMU, FPR2, LPAR1, NMS, MTRNR2L2, NMUR2, SAA1, BDKRB1, PMCH, MCHR1
ACTN1	ITGA2B	Yes	binding	24	FN1, ITGB6, PXN, PIK3CA, ACTN4, ITGB7, TLN1, CSK, ITGB1, PTK2, CRKL, ITGB5, ITGA7, VWF, SRC, FYN, ITGB4, ACTN2, ITGB8, ITGA6, PARVB, PIK3R1, GRB2, BCAR1
ACTN1	ANO6	No	-	1	UBC
ACTN1	MYH9	No	-	8	RAC1, SPTAN1, RHOA, ACTA1, TPM3, UBC, ACTN4, TPM2
ACTN1	GP1BA	No	-	3	PIK3R1, VWF, PIK3CA
ACTN1	ITGB3	No	-	33	FN1, ITGA3, SDC4, PXN, PTK2, SERPINE1, VEGFA, TLN1, ITGA9, ITGA6, ITGA5, RHOA, CSK, ITGA11, ITGA4, ITGAV, ITGB6, ITGA7, ITGA2B, VWF, SRC, ITGB7, ITGB4, ITGA2, ITGB8, ITGB1, ITGA8, ILK, ITGA1, PIK3R1, IGF1, PIK3CA, BCAR1
ACTN1	PLAU	No	-	13	FN1, ITGAV, ITGB1, SERPINE1, ITGA5, PLG, ITGA3, PIK3CA, PIK3R1, ITGB5, SRC, HRG, TRIP6
ACTN1	GP1BB	No	-	3	PIK3R1, VWF, PIK3CA
ACTN1	CD36	No	-	6	ITGB1, ITGA2B, YES1, SRC, FYN, BCAR1
ACTN1	PRKACG	No	-	11	CTNNB1, ITGB1, RHOA, CSK, ITGA1, TLN1, PTK2, PKN1, PXN, EZR, ITGA2
ACTN1	P2RY12	No	-	4	SRC, KNG1, APP, PPBP
ACTN1	GP9	No	-	3	PIK3R1, VWF, PIK3CA
ACTN1	ITGA2	Yes	binding	27	FN1, FIGF, ITGB6, PXN, PIK3CA, ACTN4, ITGA11, ITGA9, ITGB1, ITGA5, PTK2, TLN1, ITGB5, ITGA3, VWF, SRC, ITGB7, ITGB4, ACTN2, ITGB8, ITGAV, ITGA8, PARVB, ITGA1, CRKL, UBC, BCAR1
GFI1B	ITGA2B	No	-	0
TBXAS1	CD36	No	-	1	PPARA
ITGA2B	MYH9	No	-	1	ACTN4
ITGA2B	GP1BA	No	-	6	FLNC, F2, PIK3CA, PIK3R1, VWF, FLNB
ITGA2B	ITGB3	Yes	binding	44	PTPN1, APBB1IP, ITGB6, FN1, SRC, COL4A6, PTK2, RAP1A, SYK, RAP1B, GIT1, TLN1, FGA, ITGA6, CRK, LAMB1, THBS1, CSK, FGB, SOS1, SHC1, ITGA7, CD47, VWF, FGG, SPP1, COL4A1, LAMC1, AKT1, PXN, ITGB7, ITGB4, TNC, ITGB8, ITGB1, CD36, PTK2B, COL4A5, IBSP, PIK3R1, PDPK1, PIK3CA, ARF6, BCAR1
ITGA2B	PLAU	No	-	11	FGA, ITGB3, ITGB1, F2, FGG, FN1, PIK3CA, PIK3R1, ITGB5, SRC, FGB
ITGA2B	GP1BB	No	-	4	F2, PIK3R1, VWF, PIK3CA
ITGA2B	CD36	Yes	binding	11	THBS3, ITGB3, ITGB1, COMP, THBS2, THBS1, THBS4, SRC, IL13, FYN, BCAR1
ITGA2B	PRKACG	No	-	11	VASP, BCL2, ITGB1, F2, CSK, PTK2, RAP1A, SOS1, PXN, RAP1B, TLN1
ITGA2B	P2RY12	No	-	1	SRC
ITGA2B	GP9	No	-	4	F2, PIK3R1, VWF, PIK3CA
ITGA2B	ITGA2	No	-	66	COL6A6, ITGB3, LAMA3, PARVA, LAMA5, COL6A2, COL11A1, SRC, COL4A5, PTK2, LAMB3, ACTN4, COL6A5, CRKL, VASP, COL2A1, COL5A2, ITGB1, COL6A1, CRK, COL6A3, THBS1, COL4A2, PIK3CA, TNN, TNC, TLN1, LAMA2, LAMC3, TNR, FN1, TLN2, FLNB, COL24A1, LAMB4, LAMC2, ITGB5, ACTN1, ITGB6, COL5A3, COL27A1, COL4A1, LAMB2, SPP1, VWF, PXN, ITGB7, ITGB4, RELN, ACTN2, FLNC, THBS3, ITGB8, COMP, PARVB, PARVG, IBSP, THBS2, COL4A6, THBS4, BCAR1, LAMC1, COL5A1, LAMA1, LAMB1, CHAD
ANO6	MYH9	No	-	1	UBC
ANO6	ITGA2	No	-	1	UBC
MYH9	GP1BA	No	-	2	HSP90AA1, HSP90AB1
MYH9	ITGB3	No	-	4	RHOA, ROCK1, CBL, HSP90AA1
MYH9	GP1BB	No	-	2	HSP90AA1, HSP90AB1
MYH9	PRKACG	No	-	2	RHOA, IQGAP1
MYH9	GP9	No	-	2	HSP90AA1, HSP90AB1
MYH9	ITGA2	No	-	2	UBC, ACTN4
GP1BA	ITGB3	No	-	6	ITGAM, LYN, HSP90AA1, PIK3R1, PIK3CA, VWF
GP1BA	PLAU	No	-	4	ITGAM, F2, PIK3R1, PIK3CA
GP1BA	GP1BB	Yes	binding	22	PIK3CG, GP9, LYN, HSP90AB1, PRKAR2A, F11, PIK3CA, F9, YWHAZ, F2, PRKAR2B, HSP90AA1, PRKAR1A, PIK3CB, PIK3R3, VWF, PIK3CD, GP5, PIK3R1, CNBD2, PRKAR1B, PIK3R5
GP1BA	CD36	No	-	3	GP5, LYN, SELP
GP1BA	PRKACG	No	-	7	F2, PRKAR2B, PRKAR1A, CNBD2, PRKAR1B, PRKAR2A, YWHAZ
GP1BA	GP9	Yes	binding	22	PIK3CG, LYN, HSP90AB1, PRKAR2A, F11, PIK3CA, F9, YWHAZ, PRKAR2B, F2, GP1BB, HSP90AA1, PRKAR1A, PIK3CB, PIK3R3, VWF, PIK3CD, GP5, PIK3R1, CNBD2, PRKAR1B, PIK3R5
GP1BA	ITGA2	No	-	10	FLNC, PIK3CG, ITGAM, PIK3R5, PIK3CA, PIK3CB, PIK3R3, PIK3CD, VWF, FLNB
ITGB3	PLAU	Yes	binding	19	FGA, LRP1, MAPK1, ITGB1, PDGFRB, ITGA5, MAPK3, ITGA3, FN1, PIK3CA, ITGAM, PIK3R1, ITGAV, SERPINE1, SRC, FGB, FGG, PLAUR, NCL
ITGB3	GP1BB	No	-	5	LYN, PIK3R1, VWF, HSP90AA1, PIK3CA
ITGB3	CD36	Yes	binding	8	ITGB1, CD9, THBS1, ITGA2B, LYN, BCAR1, SRC, CSF1
ITGB3	PRKACG	No	-	13	ITGB1, MAPK1, RHOA, MAPK3, CSK, ITGA1, TLN1, PTK2, RAP1A, SOS1, PXN, RAP1B, ITGA2
ITGB3	P2RY12	No	-	2	SRC, CXCL1
ITGB3	GP9	No	-	5	LYN, PIK3R1, VWF, HSP90AA1, PIK3CA
ITGB3	ITGA2	Yes	binding	35	FN1, ITGA3, PXN, COL4A6, ITGAL, TLN1, ITGA9, ITGB1, ITGA5, LAMB1, THBS1, PTK2, ITGAE, ITGA11, ITGAV, ITGAM, ITGB6, SPP1, COL4A1, LAMC1, VWF, SRC, ITGB7, ITGB4, ITGAD, TNC, ITGB8, ITGAX, ITGA8, COL4A5, IBSP, ITGA1, CRK, PIK3CA, BCAR1
PLAU	GP1BB	No	-	3	F2, PIK3R1, PIK3CA
PLAU	CD36	No	-	4	SRC, ITGB3, VLDLR, ITGB1
PLAU	PRKACG	No	-	7	ITGB1, MAPK3, F2, MAPK1, ATF2, RELA, NFKB1
PLAU	P2RY12	No	-	1	SRC
PLAU	GP9	No	-	3	F2, PIK3R1, PIK3CA
PLAU	ITGA2	No	-	10	ITGB3, ITGAV, ITGB1, ITGA5, ITGA3, FN1, PIK3CA, ITGAM, ITGB5, SRC
GP1BB	CD36	No	-	2	GP5, LYN
GP1BB	PRKACG	No	-	7	F2, PRKAR2B, PRKAR1A, CNBD2, PRKAR1B, PRKAR2A, YWHAZ
GP1BB	GP9	Yes	binding	22	PIK3CG, GP1BA, LYN, HSP90AB1, PRKAR2A, F11, PIK3CA, F9, YWHAZ, F2, PRKAR2B, HSP90AA1, PRKAR1A, PIK3CB, PIK3R3, VWF, PIK3CD, GP5, PIK3R1, CNBD2, PRKAR1B, PIK3R5
GP1BB	ITGA2	No	-	7	PIK3CG, PIK3R5, PIK3CA, PIK3CB, PIK3R3, PIK3CD, VWF
CD36	PRKACG	No	-	4	CREBBP, EP300, ITGB1, EDN1
CD36	P2RY12	No	-	1	SRC
CD36	GP9	No	-	2	GP5, LYN
CD36	ITGA2	No	-	9	THBS3, ITGB3, ITGB1, COMP, THBS2, THBS1, THBS4, SRC, BCAR1
PRKACG	P2RY12	No	-	6	GNG2, CXCL12, GNAI3, SLC9A3R1, AGT, GNB1
PRKACG	GP9	No	-	7	F2, PRKAR2B, PRKAR1A, CNBD2, PRKAR1B, PRKAR2A, YWHAZ
PRKACG	ITGA2	Yes	activation, binding	8	VASP, ITGB1, PTK2, ITGA1, PRKACB, PXN, PRKACA, TLN1
P2RY12	ITGA2	No	-	1	SRC
GP9	ITGA2	No	-	7	PIK3CG, PIK3R5, PIK3CA, PIK3CB, PIK3R3, PIK3CD, VWF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ACTN1	ITGA2B	No	-	3	SRC, TLN1, PTK2
ACTN1	ITGB3	No	-	4	SRC, PXN, TLN1, PTK2
ITGA2B	GP1BA	Yes	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	4	CD9, ITGB3, GP1BB, CD47
ITGA2B	ITGB3	Yes	ITGA2B-ITGB3 complex;ITGA2b-ITGB3-CD47-SRC complex;ITGA2b-ITGB3-CD47-FAK complex;ITGA2B-ITGB3-F11R complex;ITGA2B-ITGB3-ICAM4 complex;ITGA2b-ITGB3-CD9-GP1b-CD47 complex;ITGA2B-ITGB3-CIB1 complex;ITGA2B-ITGB3-FN1-TGM2 complex;ITGA2b-ITGB3-CD9 complex;ITGA2b-ITGB3-TLN1 complex	12	FN1, GP1BA, CD9, CD47, GP1BB, PTK2, F11R, ICAM4, SRC, TGM2, CIB1, TLN1
ITGA2B	GP1BB	Yes	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	4	CD9, ITGB3, CD47, GP1BA
ITGA2B	ITGA2	No	-	1	CD47
GP1BA	ITGB3	Yes	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	4	CD9, CD47, GP1BB, ITGA2B
GP1BA	GP1BB	Yes	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	4	CD9, ITGB3, CD47, ITGA2B
GP1BA	ITGA2	No	-	1	CD47
ITGB3	GP1BB	Yes	ITGA2b-ITGB3-CD9-GP1b-CD47 complex	4	CD9, CD47, GP1BA, ITGA2B
ITGB3	ITGA2	No	-	2	CD47, COL6A3
GP1BB	ITGA2	No	-	1	CD47

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
ITGA2B	GP1BA	No	1	FLNA
ITGA2B	ITGB3	Yes	4	FLNA, FGG, ITGB3, ITGA2B
GP1BA	ITGB3	No	1	FLNA
GP1BB	GP9	Yes	2	GP9, GP1BB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Platelet activation	hsa04611	5.66	13	PRKACG, ITGB3, GP1BA, GP9, P2RY12, GP1BB, TBXA2R, ITGA2B, TBXAS1, RASGRP2, P2RX1, GP6, ITGA2
ECM-receptor interaction	hsa04512	6.09	8	ITGB3, CD36, GP1BA, GP9, GP1BB, ITGA2B, GP6, ITGA2
Hematopoietic cell lineage	hsa04640	6.18	7	ITGB3, CD36, GP1BA, GP9, GP1BB, ITGA2B, ITGA2
Regulation of actin cytoskeleton	hsa04810	4.9	5	ACTN1, ITGB3, MYH9, ITGA2B, ITGA2
Proteoglycans in cancer	hsa05205	5.02	4	ITGA2, ITGB3, PRKACG, PLAU
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	4	ACTN1, ITGB3, ITGA2, ITGA2B
Dilated cardiomyopathy	hsa05414	6.08	4	ITGA2, PRKACG, ITGB3, ITGA2B
Pathways in cancer	hsa05200	3.98	4	ITGA2, PRKACG, ITGA2B, RASGRP2
Focal adhesion	hsa04510	4.92	4	ITGA2, ITGB3, ACTN1, ITGA2B
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	3	ITGB3, ITGA2, ITGA2B
Calcium signaling pathway	hsa04020	5.22	3	TBXA2R, PRKACG, P2RX1
Phagosome	hsa04145	5.27	3	ITGB3, CD36, ITGA2
Rap1 signaling pathway	hsa04015	4.97	3	ITGB3, ITGA2B, RASGRP2
PI3K-Akt signaling pathway	hsa04151	4.21	3	ITGB3, ITGA2, ITGA2B
Neuroactive ligand-receptor interaction	hsa04080	4.58	2	TBXA2R, P2RX1
MicroRNAs in cancer	hsa05206	5.38	2	ITGB3, PLAU
Viral carcinogenesis	hsa05203	5.08	2	PRKACG, ACTN1
Tight junction	hsa04530	5.53	2	MYH9, ACTN1
Ras signaling pathway	hsa04014	4.9	2	PRKACG, RASGRP2
Amoebiasis	hsa05146	5.82	2	PRKACG, ACTN1
Small cell lung cancer	hsa05222	6.17	2	ITGA2, ITGA2B
MAPK signaling pathway	hsa04010	4.63	2	PRKACG, RASGRP2
Thyroid hormone signaling pathway	hsa04919	5.82	2	ITGB3, PRKACG
Chemokine signaling pathway	hsa04062	5.19	2	PRKACG, RASGRP2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Organismal Systems	NEW	1.33	0.0	PRKACG, GFI1B, GP1BA, ACTN1, GP9, MYH9, PLAU, GP1BB, TBXAS1, ITGA2B, TBXA2R, P2RY12, ITGA2, P2RX1, CD36, GP6, ITGB3, RASGRP2
Cancers: Specific types	NEW	4.1	0.026	ITGB3, CD36, ACTN1, GFI1B, ITGA2B, MYH9, GP6, ITGA2
Platelet activation (hsa04611)	-	5.66	0.0	PRKACG, ITGB3, GP1BA, GP9, P2RY12, GP1BB, TBXA2R, ITGA2B, TBXAS1, RASGRP2, P2RX1, GP6, ITGA2
Immune system	NEW	2.92	0.0	PRKACG, ITGB3, ACTN1, GP1BA, GP9, MYH9, PLAU, GP1BB, TBXA2R, ITGA2B, TBXAS1, P2RY12, ITGA2, P2RX1, CD36, GP6, RASGRP2
Environmental Information Processing	NEW	1.71	0.015	PRKACG, GFI1B, CD36, ACTN1, GP9, PLAU, GP1BB, MYH9, ITGA2B, TBXA2R, ITGA2, P2RX1, GP6, GP1BA, ITGB3, RASGRP2
Cell motility	NEW	4.9	0.02	GFI1B, ACTN1, PLAU, ITGB3, ITGA2B, MYH9, ITGA2
Cardiovascular diseases	NEW	5.06	0.012	PRKACG, ITGB3, ACTN1, ITGA2B, ITGA2
Pathways in cancer (hsa05200)	-	3.98	0.0	PRKACG, GFI1B, ITGB3, ACTN1, MYH9, ITGA2B, TBXA2R, RASGRP2, GP6, CD36, ITGA2
Signaling molecules and interaction	NEW	3.09	0.0	GFI1B, ACTN1, GP1BA, GP9, PLAU, GP1BB, ITGB3, ITGA2B, TBXA2R, GP6, P2RX1, CD36, ITGA2
Amoebiasis (hsa05146)	-	5.82	0.001	ITGB3, CD36, ACTN1, PLAU, PRKACG, ITGA2
Small cell lung cancer (hsa05222)	-	6.17	0.047	ITGA2, ITGB3, GFI1B, ITGA2B
Hematopoietic cell lineage (hsa04640)	-	6.18	0.0	ITGB3, CD36, GP1BA, GP9, PLAU, GP1BB, ITGA2B, ITGA2
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	0.036	ITGA2, ITGB3, ACTN1, ITGA2B
ECM-receptor interaction (hsa04512)	-	6.09	0.0	ITGB3, CD36, GP1BA, GP9, GP1BB, GFI1B, ITGA2B, GP6, ITGA2
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)	-	6.32	0.015	ACTN1, ITGB3, ITGA2, ITGA2B
Dilated cardiomyopathy (hsa05414)	-	6.08	0.01	ITGA2, PRKACG, ITGB3, ACTN1, ITGA2B
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.02	GFI1B, ACTN1, PLAU, ITGB3, ITGA2B, MYH9, ITGA2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Hemostasis	R-HSA-109582	3.98	15	PRKACG, ITGB3, ACTN1, CD36, GP9, PLAU, GP1BB, P2RY12, ITGA2B, ITGA2, TBXA2R, GP6, P2RX1, GP1BA, RASGRP2
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	11	ITGB3, CD36, GP1BA, GP9, GP1BB, P2RY12, ITGA2B, ACTN1, TBXA2R, GP6, RASGRP2
Signal Transduction	R-HSA-162582	1.78	7	PRKACG, P2RY12, ITGB3, TBXA2R, ITGA2B, MYH9, RASGRP2
Innate Immune System	R-HSA-168249	3.17	6	ITGB3, CD36, MYH9, ITGA2B, PRKACG, RASGRP2
Immune System	R-HSA-168256	2.37	6	ITGB3, CD36, MYH9, ITGA2B, PRKACG, RASGRP2
Signaling by GPCR	R-HSA-372790	2.68	6	P2RY12, ITGB3, TBXA2R, ITGA2B, PRKACG, RASGRP2
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.77	6	ITGB3, GP1BA, GP9, GP1BB, ITGA2B, RASGRP2
Platelet Adhesion to exposed collagen	R-HSA-75892	9.08	5	GP9, GP6, GP1BB, GP1BA, ITGA2
Developmental Biology	R-HSA-1266738	3.48	5	ITGA2, ITGB3, MYH9, ITGA2B, CD36
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	4	ITGB3, TBXA2R, ITGA2B, RASGRP2
Axon guidance	R-HSA-422475	3.93	4	ITGA2, ITGB3, MYH9, ITGA2B
Extracellular matrix organization	R-HSA-1474244	4.91	4	ACTN1, ITGB3, ITGA2, ITGA2B
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	4	ITGB3, ACTN1, ITGA2B, CD36
Platelet degranulation	R-HSA-114608	6.68	4	ITGB3, ACTN1, ITGA2B, CD36
GP1b-IX-V activation signalling	R-HSA-430116	9.66	3	GP9, GP1BB, GP1BA
Metabolism	R-HSA-1430728	2.34	3	PRKACG, TBXAS1, CD36
Downstream signal transduction	R-HSA-186763	4.65	3	ITGB3, PRKACG, ITGA2B
Adaptive Immune System	R-HSA-1280218	3.19	3	PRKACG, CD36, RASGRP2
Integrin cell surface interactions	R-HSA-216083	6.57	3	ITGB3, ITGA2, ITGA2B
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	PRKACG, ITGB3, ITGA2B
MAPK family signaling cascades	R-HSA-5683057	4.89	3	ITGB3, PRKACG, ITGA2B
Signalling by NGF	R-HSA-166520	4.23	3	PRKACG, ITGB3, ITGA2B
Signaling by VEGF	R-HSA-194138	4.66	3	PRKACG, ITGB3, ITGA2B
ECM proteoglycans	R-HSA-3000178	6.75	3	ITGB3, ITGA2, ITGA2B
Syndecan interactions	R-HSA-3000170	8.23	3	ITGB3, ITGA2, ACTN1
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.1	3	ITGB3, ITGA2, ACTN1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	ITGB3, PRKACG, ITGA2B
Signaling by FGFR4	R-HSA-5654743	4.69	3	PRKACG, ITGB3, ITGA2B
Signaling by FGFR3	R-HSA-5654741	4.69	3	ITGB3, PRKACG, ITGA2B
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	ITGB3, PRKACG, ITGA2B
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	PRKACG, TBXAS1, CD36
L1CAM interactions	R-HSA-373760	6.19	3	ITGB3, ITGA2, ITGA2B
Signaling by FGFR	R-HSA-190236	4.67	3	PRKACG, ITGB3, ITGA2B
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	ITGB3, ITGA2B, RASGRP2
GPCR downstream signaling	R-HSA-388396	3.07	3	TBXA2R, P2RY12, RASGRP2
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.52	3	GP9, GP1BB, GP1BA
Signaling by ERBB2	R-HSA-1227986	4.66	3	PRKACG, ITGB3, ITGA2B
DAP12 signaling	R-HSA-2424491	4.64	3	PRKACG, ITGB3, ITGA2B
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	PRKACG, ITGB3, ITGA2B
Signaling by EGFR	R-HSA-177929	4.59	3	PRKACG, ITGB3, ITGA2B
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	PRKACG, ITGB3, ITGA2B
Signaling by FGFR2	R-HSA-5654738	4.68	3	ITGB3, PRKACG, ITGA2B
Signaling by FGFR1	R-HSA-5654736	4.69	3	PRKACG, ITGB3, ITGA2B
Integrin alphaIIb beta3 signaling	R-HSA-354192	8.23	3	ITGB3, ITGA2B, RASGRP2
DAP12 interactions	R-HSA-2172127	4.56	3	PRKACG, ITGB3, ITGA2B
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	PRKACG, ITGB3, ITGA2B
Signaling by PDGF	R-HSA-186797	4.53	3	ITGB3, PRKACG, ITGA2B
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.7	3	GP9, GP1BB, GP1BA
Signal transduction by L1	R-HSA-445144	8.59	2	ITGB3, ITGA2B
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	ITGB3, ITGA2B
Signaling by Interleukins	R-HSA-449147	4.71	2	ITGB3, ITGA2B
Interleukin-2 signaling	R-HSA-451927	5.05	2	ITGB3, ITGA2B
Frs2-mediated activation	R-HSA-170968	5.12	2	ITGB3, ITGA2B
MAP2K and MAPK activation	R-HSA-5674135	7.66	2	ITGB3, ITGA2B
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	ITGB3, GP6
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	ITGB3, ITGA2B
IGF1R signaling cascade	R-HSA-2428924	4.85	2	ITGB3, ITGA2B
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	ITGB3, ITGA2B
Signaling by ERBB4	R-HSA-1236394	4.7	2	ITGB3, ITGA2B
Signaling by Insulin receptor	R-HSA-74752	4.73	2	ITGB3, ITGA2B
Disease	R-HSA-1643685	3.33	2	TBXAS1, CD36
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	ITGB3, ITGA2B
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	ITGB3, ITGA2B
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	ITGB3, ITGA2B
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	ITGB3, ITGA2B
IRS-mediated signalling	R-HSA-112399	4.87	2	ITGB3, ITGA2B
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.08	2	ITGB3, ITGA2B
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	ITGB3, ITGA2B
SOS-mediated signalling	R-HSA-112412	5.15	2	ITGB3, ITGA2B
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	ITGB3, ITGA2B
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	ITGB3, ITGA2B
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	ITGB3, ITGA2B
Signaling by Leptin	R-HSA-2586552	5.1	2	ITGB3, ITGA2B
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	TBXA2R, P2RY12
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	ITGB3, ITGA2B
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	ITGB3, ITGA2B
Signalling to ERKs	R-HSA-187687	5.04	2	ITGB3, ITGA2B
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	ITGB3, ITGA2B
Signal amplification	R-HSA-392518	7.98	2	TBXA2R, P2RY12
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	PRKACG, ANO6
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	ITGB3, ITGA2B
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	ITGB3, ITGA2B
Rap1 signalling	R-HSA-392517	8.98	2	PRKACG, RASGRP2
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	ITGB3, ITGA2B
Prolonged ERK activation events	R-HSA-169893	5.11	2	ITGB3, ITGA2B
GPCR ligand binding	R-HSA-500792	4.19	2	TBXA2R, P2RY12
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	ITGB3, ITGA2B
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	ITGB3, ITGA2B
Signalling to RAS	R-HSA-167044	5.08	2	ITGB3, ITGA2B
G alpha (q) signalling events	R-HSA-416476	5.42	2	TBXA2R, RASGRP2
ARMS-mediated activation	R-HSA-170984	5.12	2	ITGB3, ITGA2B
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.08	2	ITGB3, ITGA2B
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	ITGB3, ITGA2B
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	ITGB3, ITGA2B
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	ITGB3, ITGA2B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Integrin cell surface interactions (R-HSA-216083)	-	6.57	0.02	GFI1B, ITGB3, ITGA2, ITGA2B
Platelet Aggregation (Plug Formation) (R-HSA-76009)	-	7.77	0.0	ITGB3, GP1BA, GP9, GP1BB, ITGA2B, RASGRP2
Platelet degranulation (R-HSA-114608)	-	6.68	0.005	ITGB3, ACTN1, ITGA2B, CD36
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.0	ITGB3, CD36, GP1BA, GP9, PLAU, GP1BB, P2RY12, ITGA2B, ACTN1, TBXA2R, GP6, RASGRP2
ECM proteoglycans (R-HSA-3000178)	-	6.75	0.001	ITGA2, GFI1B, ITGB3, ACTN1, ITGA2B
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005)	-	6.59	0.006	ITGB3, ACTN1, ITGA2B, CD36
Integrin alphaIIb beta3 signaling (R-HSA-354192)	-	8.23	0.0	ITGB3, PLAU, ITGA2B, RASGRP2
Syndecan interactions (R-HSA-3000170)	-	8.23	0.01	ITGB3, ITGA2, ACTN1
GP1b-IX-V activation signalling (R-HSA-430116)	-	9.66	0.0	GP9, GP1BB, GP1BA
Intrinsic Pathway of Fibrin Clot Formation (R-HSA-140837)	-	8.52	0.004	GP9, GP1BB, GP1BA
Platelet Adhesion to exposed collagen (R-HSA-75892)	-	9.08	0.0	GP9, GP1BA, GP1BB, GP6, ITGA2
Non-integrin membrane-ECM interactions (R-HSA-3000171)	-	7.1	0.0	GFI1B, ITGB3, ACTN1, MYH9, ITGA2
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)	-	7.7	0.017	GP9, GP1BB, GP1BA
Hemostasis (R-HSA-109582)	-	3.98	0.0	PRKACG, GFI1B, GP1BA, ACTN1, GP9, PLAU, GP1BB, MYH9, ITGA2B, TBXA2R, P2RY12, RASGRP2, P2RX1, CD36, GP6, ITGB3, ITGA2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	20	PRKACG, ANO6, GFI1B, ACTN1, GP1BA, GP9, MYH9, SLFN14, GP1BB, ITGB3, ITGA2B, TBXA2R, ITGA2, P2RX1, CD36, GP6, TBXAS1, NBEAL2, PLAU, RASGRP2
protein binding (GO:0005515)	0.46	14	GFI1B, ACTN1, ANO6, GP9, PLAU, GP1BB, MYH9, ITGA2B, TBXA2R, ITGA2, CD36, GP1BA, ITGB3, GP6
molecular transducer activity (GO:0060089)	2.32	9	P2RY12, CD36, GP1BA, GP1BB, ITGB3, TBXA2R, GP6, P2RX1, ITGA2
signaling receptor activity (GO:0038023)	2.49	9	ITGB3, CD36, GP1BA, GP1BB, P2RY12, TBXA2R, GP6, P2RX1, ITGA2
receptor activity (GO:0004872)	2.32	9	ITGB3, CD36, GP1BA, GP1BB, P2RY12, TBXA2R, GP6, P2RX1, ITGA2
signal transducer activity (GO:0004871)	2.28	9	P2RY12, CD36, GP1BA, GP1BB, ITGB3, TBXA2R, GP6, P2RX1, ITGA2
cation binding (GO:0043169)	1.4	7	GFI1B, ACTN1, ITGA2B, TBXAS1, RASGRP2, P2RX1, ITGA2
organic cyclic compound binding (GO:0097159)	1.05	7	GFI1B, ACTN1, SLFN14, MYH9, PRKACG, P2RX1, TBXAS1
ion binding (GO:0043167)	1.36	7	GFI1B, ACTN1, ITGA2B, TBXAS1, RASGRP2, P2RX1, ITGA2
transmembrane signaling receptor activity (GO:0004888)	2.57	7	P2RY12, GP1BA, GP1BB, TBXA2R, GP6, P2RX1, ITGA2
macromolecular complex binding (GO:0044877)	2.61	7	CD36, ACTN1, SLFN14, ITGA2B, MYH9, GP6, ITGA2
metal ion binding (GO:0046872)	1.41	7	GFI1B, ACTN1, ITGA2B, TBXAS1, RASGRP2, P2RX1, ITGA2
heterocyclic compound binding (GO:1901363)	1.06	7	GFI1B, ACTN1, SLFN14, MYH9, PRKACG, P2RX1, TBXAS1
transmembrane receptor activity (GO:0099600)	2.53	7	P2RY12, GP1BA, GP1BB, TBXA2R, GP6, P2RX1, ITGA2
catalytic activity (GO:0003824)	1.05	6	ITGB3, PLAU, TBXAS1, PRKACG, SLFN14, MYH9
identical protein binding (GO:0042802)	2.63	6	ITGB3, ANO6, ACTN1, GP1BB, ITGA2B, MYH9
protein complex binding (GO:0032403)	3.09	5	ACTN1, MYH9, GP6, ITGA2B, ITGA2
adenyl nucleotide binding (GO:0030554)	2.4	4	MYH9, SLFN14, PRKACG, P2RX1
carbohydrate derivative binding (GO:0097367)	2.03	4	MYH9, SLFN14, PRKACG, P2RX1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	4	MYH9, SLFN14, PRKACG, P2RX1
nucleotide binding (GO:0000166)	1.96	4	MYH9, SLFN14, PRKACG, P2RX1
small molecule binding (GO:0036094)	1.89	4	MYH9, SLFN14, PRKACG, P2RX1
ribonucleotide binding (GO:0032553)	2.19	4	MYH9, SLFN14, PRKACG, P2RX1
adenyl ribonucleotide binding (GO:0032559)	2.41	4	MYH9, SLFN14, PRKACG, P2RX1
ATP binding (GO:0005524)	2.43	4	MYH9, SLFN14, PRKACG, P2RX1
purine nucleoside binding (GO:0001883)	2.22	4	MYH9, SLFN14, PRKACG, P2RX1
ribonucleoside binding (GO:0032549)	2.22	4	MYH9, SLFN14, PRKACG, P2RX1
purine ribonucleotide binding (GO:0032555)	2.2	4	MYH9, SLFN14, PRKACG, P2RX1
purine nucleotide binding (GO:0017076)	2.19	4	MYH9, SLFN14, PRKACG, P2RX1
protein dimerization activity (GO:0046983)	2.72	4	ITGA2, MYH9, ACTN1, ANO6
molecular function regulator (GO:0098772)	2.51	4	TBXA2R, P2RY12, GP1BA, RASGRP2
purine ribonucleoside binding (GO:0032550)	2.22	4	MYH9, SLFN14, PRKACG, P2RX1
nucleoside phosphate binding (GO:1901265)	1.96	4	MYH9, SLFN14, PRKACG, P2RX1
nucleoside binding (GO:0001882)	2.21	4	MYH9, SLFN14, PRKACG, P2RX1
hydrolase activity (GO:0016787)	1.9	3	SLFN14, MYH9, PLAU
G-protein coupled receptor activity (GO:0004930)	2.95	3	TBXA2R, P2RY12, GP1BA
extracellular matrix binding (GO:0050840)	5.79	3	ITGB3, ITGA2, ITGA2B
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	3	TBXA2R, P2RY12, RASGRP2
lipid binding (GO:0008289)	3.26	3	NBEAL2, CD36, RASGRP2
nucleic acid binding (GO:0003676)	1.44	3	MYH9, GFI1B, ACTN1
receptor binding (GO:0005102)	2.43	3	ITGB3, ITGA2, ACTN1
cell adhesion molecule binding (GO:0050839)	4.5	3	ITGB3, ITGA2, ACTN1
protein homodimerization activity (GO:0042803)	3.16	3	MYH9, ANO6, ACTN1
cation channel activity (GO:0005261)	4.04	2	ANO6, P2RX1
cytokine binding (GO:0019955)	5.21	2	ITGB3, CD36
substrate-specific channel activity (GO:0022838)	3.67	2	ANO6, P2RX1
intramolecular oxidoreductase activity (GO:0016860)	5.75	2	ITGB3, TBXAS1
transition metal ion binding (GO:0046914)	2.48	2	TBXAS1, P2RX1
growth factor binding (GO:0019838)	4.89	2	ITGB3, CD36
actin binding (GO:0003779)	3.74	2	MYH9, ACTN1
purinergic receptor activity (GO:0035586)	6.52	2	P2RY12, P2RX1
transferase activity (GO:0016740)	1.95	2	PRKACG, PLAU
calcium ion binding (GO:0005509)	3.17	2	ACTN1, RASGRP2
passive transmembrane transporter activity (GO:0022803)	3.6	2	ANO6, P2RX1
RNA binding (GO:0003723)	2.36	2	MYH9, ACTN1
integrin binding (GO:0005178)	5.07	2	ITGA2, ACTN1
cation transmembrane transporter activity (GO:0008324)	3.32	2	ANO6, P2RX1
transporter activity (GO:0005215)	2.57	2	ANO6, P2RX1
ion channel activity (GO:0005216)	3.71	2	ANO6, P2RX1
kinase activity (GO:0016301)	2.93	2	PRKACG, PLAU
actin filament binding (GO:0051015)	4.93	2	MYH9, ACTN1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	2	ANO6, P2RX1
purinergic nucleotide receptor activity (GO:0001614)	6.69	2	P2RY12, P2RX1
substrate-specific transporter activity (GO:0022892)	2.72	2	ANO6, P2RX1
isomerase activity (GO:0016853)	4.62	2	ITGB3, TBXAS1
cytoskeletal protein binding (GO:0008092)	3.02	2	MYH9, ACTN1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	PRKACG, PLAU
virus receptor activity (GO:0001618)	5.49	2	ITGB3, ITGA2
ion transmembrane transporter activity (GO:0015075)	3.04	2	ANO6, P2RX1
transmembrane transporter activity (GO:0022857)	2.82	2	ANO6, P2RX1
channel activity (GO:0015267)	3.6	2	ANO6, P2RX1
gated channel activity (GO:0022836)	3.96	2	ANO6, P2RX1
collagen binding (GO:0005518)	5.58	2	GP6, ITGA2
nucleotide receptor activity (GO:0016502)	6.69	2	P2RY12, P2RX1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
purinergic nucleotide receptor activity (GO:0001614)	-	6.69	0.046	P2RY12, P2RX1
integrin binding (GO:0005178)	-	5.07	0.003	ITGA2, ITGB3, PLAU, GFI1B, ACTN1
endopeptidase activity (GO:0004175)	NEW	3.63	0.008	GFI1B, ACTN1, GP1BA, GP9, PLAU, ITGA2B, MYH9, ITGA2
signaling receptor activity (GO:0038023)	-	2.49	0.0	GFI1B, ACTN1, GP1BA, PLAU, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RY12, GP6, P2RX1, CD36, ITGA2
extracellular matrix binding (GO:0050840)	-	5.79	0.003	ACTN1, ITGB3, GFI1B, ITGA2B, ITGA2
growth factor binding (GO:0019838)	-	4.89	0.007	ITGB3, PLAU, MYH9, ACTN1, CD36
molecular transducer activity (GO:0060089)	-	2.32	0.005	GFI1B, ACTN1, GP1BA, P2RY12, GP1BB, ITGB3, ITGA2B, TBXA2R, GP6, P2RX1, CD36, PLAU, ITGA2
transmembrane signaling receptor activity (GO:0004888)	-	2.57	0.001	GFI1B, ACTN1, GP1BA, P2RY12, GP1BB, ITGB3, ITGA2B, TBXA2R, GP6, P2RX1, PLAU, ITGA2
peptidase activity, acting on L-amino acid peptides (GO:0070011)	NEW	3.26	0.013	GFI1B, ACTN1, GP1BA, GP9, PLAU, ITGB3, ITGA2B, MYH9, ITGA2
receptor activity (GO:0004872)	-	2.32	0.002	GFI1B, ITGB3, GP1BA, P2RY12, GP1BB, TBXA2R, ITGA2B, ACTN1, MYH9, GP6, P2RX1, CD36, PLAU, ITGA2
signal transducer activity (GO:0004871)	-	2.28	0.005	GFI1B, ACTN1, GP1BA, P2RY12, GP1BB, ITGB3, ITGA2B, TBXA2R, GP6, P2RX1, CD36, PLAU, ITGA2
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.05	ITGB3, ACTN1, GP1BA, PLAU, GFI1B, MYH9, ITGA2
cell adhesion molecule binding (GO:0050839)	-	4.5	0.045	ACTN1, ITGB3, PLAU, GFI1B, ITGA2
peptidase activity (GO:0008233)	NEW	3.23	0.017	GFI1B, ACTN1, GP1BA, GP9, PLAU, ITGB3, ITGA2B, MYH9, ITGA2
nucleotide receptor activity (GO:0016502)	-	6.69	0.046	P2RY12, P2RX1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	21	PRKACG, GFI1B, ACTN1, GP1BA, ITGA2, ANO6, SLFN14, GP1BB, TBXAS1, ITGA2B, GP9, TBXA2R, P2RY12, MYH9, P2RX1, CD36, GP6, PLAU, NBEAL2, ITGB3, RASGRP2
biological regulation (GO:0065007)	0.39	19	PRKACG, ANO6, GFI1B, ACTN1, GP1BA, GP9, MYH9, PLAU, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RY12, ITGA2, P2RX1, CD36, GP6, TBXAS1, RASGRP2
single-organism process (GO:0044699)	0.48	19	PRKACG, GFI1B, CD36, GP1BA, GP9, ANO6, PLAU, GP1BB, ITGB3, ITGA2B, ACTN1, TBXA2R, P2RY12, MYH9, P2RX1, GP6, TBXAS1, NBEAL2, ITGA2
regulation of biological process (GO:0050789)	0.45	18	PRKACG, ANO6, GFI1B, ACTN1, CD36, MYH9, P2RY12, GP1BB, TBXAS1, ITGA2B, TBXA2R, ITGA2, P2RX1, GP6, PLAU, GP1BA, ITGB3, RASGRP2
single-organism cellular process (GO:0044763)	0.65	17	ITGB3, ACTN1, ANO6, GP9, PLAU, GP1BB, TBXAS1, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, CD36, NBEAL2, GP1BA, MYH9
regulation of cellular process (GO:0050794)	0.5	17	PRKACG, ANO6, GFI1B, GP1BA, CD36, MYH9, PLAU, GP1BB, ITGB3, ITGA2B, ACTN1, TBXA2R, P2RY12, ITGA2, P2RX1, GP6, RASGRP2
multicellular organismal process (GO:0032501)	1.45	16	PRKACG, GFI1B, GP1BA, CD36, GP9, ANO6, PLAU, GP1BB, ITGB3, GP6, TBXA2R, P2RY12, MYH9, P2RX1, TBXAS1, ITGA2
regulation of biological quality (GO:0065008)	1.68	15	PRKACG, ITGB3, P2RY12, GP1BA, GP9, ANO6, PLAU, GP1BB, TBXA2R, MYH9, GP6, P2RX1, CD36, TBXAS1, ITGA2
signal transduction (GO:0007165)	1.28	15	PRKACG, ITGB3, CD36, ANO6, ITGA2, P2RY12, GP1BB, MYH9, ITGA2B, TBXA2R, GP6, P2RX1, GP1BA, PLAU, RASGRP2
single-multicellular organism process (GO:0044707)	1.78	14	PRKACG, ITGB3, P2RY12, GP1BA, GP9, ANO6, PLAU, GP1BB, GFI1B, MYH9, GP6, P2RX1, CD36, ITGA2
response to stimulus (GO:0050896)	1.22	13	PRKACG, ITGB3, CD36, GP1BA, GP9, PLAU, GP1BB, P2RY12, TBXA2R, RASGRP2, P2RX1, SLFN14, ITGA2
hemostasis (GO:0007599)	4.5	12	ITGB3, CD36, GP1BA, GP9, ANO6, PLAU, GP1BB, P2RY12, PRKACG, GP6, P2RX1, ITGA2
regulation of body fluid levels (GO:0050878)	3.76	12	ITGB3, GP1BA, ANO6, GP9, PLAU, GP1BB, P2RY12, PRKACG, ITGA2, P2RX1, CD36, GP6
blood coagulation (GO:0007596)	4.52	12	ITGB3, CD36, GP1BA, GP9, ANO6, PLAU, GP1BB, P2RY12, PRKACG, GP6, P2RX1, ITGA2
coagulation (GO:0050817)	4.51	12	ITGB3, ANO6, GP1BA, GP9, PLAU, GP1BB, CD36, PRKACG, P2RY12, ITGA2, P2RX1, GP6
cell surface receptor signaling pathway (GO:0007166)	2.09	12	ITGB3, CD36, GP1BA, ANO6, P2RY12, GP1BB, PRKACG, ITGA2B, MYH9, GP6, P2RX1, ITGA2
positive regulation of biological process (GO:0048518)	1.2	12	PRKACG, ITGB3, P2RY12, ANO6, PLAU, TBXA2R, ITGA2B, MYH9, P2RX1, CD36, TBXAS1, ITGA2
metabolic process (GO:0008152)	0.58	11	PRKACG, GFI1B, CD36, GP1BA, GP9, PLAU, GP1BB, MYH9, TBXAS1, P2RX1, SLFN14
organic substance metabolic process (GO:0071704)	0.63	11	PRKACG, GFI1B, CD36, GP1BA, GP9, PLAU, GP1BB, TBXAS1, MYH9, P2RX1, SLFN14
cellular component organization (GO:0016043)	1.24	11	ITGB3, ACTN1, GP1BA, ANO6, P2RY12, GFI1B, ITGA2B, MYH9, P2RX1, CD36, ITGA2
cellular component organization or biogenesis (GO:0071840)	1.22	11	GFI1B, ACTN1, GP1BA, ANO6, P2RY12, ITGB3, ITGA2B, MYH9, P2RX1, CD36, ITGA2
primary metabolic process (GO:0044238)	0.69	11	PRKACG, GFI1B, CD36, GP1BA, GP9, SLFN14, GP1BB, TBXAS1, MYH9, P2RX1, PLAU
developmental process (GO:0032502)	1.36	10	PRKACG, ITGB3, GP1BA, ACTN1, ANO6, PLAU, GFI1B, MYH9, NBEAL2, ITGA2
regulation of metabolic process (GO:0019222)	1.02	10	PRKACG, ITGB3, GP1BA, ACTN1, PLAU, GFI1B, MYH9, P2RX1, CD36, ITGA2
regulation of cellular metabolic process (GO:0031323)	1.07	10	PRKACG, ITGB3, ACTN1, GP1BA, PLAU, GFI1B, MYH9, P2RX1, CD36, ITGA2
regulation of multicellular organismal process (GO:0051239)	1.87	10	ITGB3, GP1BA, ANO6, P2RY12, TBXAS1, TBXA2R, P2RX1, CD36, PLAU, ITGA2
cell adhesion (GO:0007155)	2.82	10	ITGB3, GP1BA, ACTN1, GP9, P2RY12, GP1BB, CD36, ITGA2B, MYH9, ITGA2
biological adhesion (GO:0022610)	2.81	10	ITGB3, ACTN1, GP1BA, GP9, GP1BB, P2RY12, ITGA2B, MYH9, CD36, ITGA2
establishment of localization (GO:0051234)	1.48	9	P2RY12, CD36, ACTN1, ANO6, ITGB3, ITGA2B, MYH9, P2RX1, ITGA2
regulation of primary metabolic process (GO:0080090)	1.08	9	PRKACG, ITGB3, GP1BA, ACTN1, GFI1B, MYH9, P2RX1, CD36, ITGA2
regulation of macromolecule metabolic process (GO:0060255)	1.08	9	PRKACG, ITGB3, ACTN1, GP1BA, GFI1B, MYH9, P2RX1, CD36, ITGA2
macromolecule metabolic process (GO:0043170)	0.83	9	GFI1B, CD36, GP1BA, GP9, PLAU, GP1BB, PRKACG, MYH9, SLFN14
single-organism developmental process (GO:0044767)	1.49	9	PRKACG, ITGB3, ACTN1, GP1BA, PLAU, GFI1B, MYH9, NBEAL2, ITGA2
response to chemical (GO:0042221)	1.98	9	P2RY12, CD36, PLAU, PRKACG, TBXA2R, RASGRP2, P2RX1, SLFN14, ITGA2
regulation of molecular function (GO:0065009)	1.78	9	ITGB3, P2RY12, GP1BA, PLAU, PRKACG, TBXA2R, RASGRP2, P2RX1, ITGA2
regulation of localization (GO:0032879)	1.94	9	ITGB3, ACTN1, ANO6, PLAU, CD36, ITGA2B, P2RY12, P2RX1, ITGA2
localization (GO:0051179)	1.4	9	ITGB3, CD36, ACTN1, ANO6, P2RY12, ITGA2B, MYH9, P2RX1, ITGA2
positive regulation of cellular process (GO:0048522)	1.3	9	ITGB3, CD36, ANO6, PLAU, MYH9, ITGA2B, PRKACG, P2RX1, ITGA2
transport (GO:0006810)	1.51	8	ITGB3, ACTN1, ANO6, P2RY12, ITGA2B, MYH9, P2RX1, CD36
regulation of catalytic activity (GO:0050790)	1.97	8	PRKACG, P2RY12, GP1BA, ITGB3, TBXA2R, RASGRP2, P2RX1, ITGA2
regulation of protein metabolic process (GO:0051246)	1.93	8	PRKACG, ITGB3, CD36, GP1BA, GFI1B, MYH9, P2RX1, ITGA2
cell activation (GO:0001775)	3.47	8	ITGB3, GP1BA, ACTN1, GP9, GP1BB, P2RY12, P2RX1, GP6
regulation of cellular protein metabolic process (GO:0032268)	1.99	8	PRKACG, ITGB3, CD36, GP1BA, GFI1B, MYH9, P2RX1, ITGA2
platelet activation (GO:0030168)	4.96	8	ITGB3, GP1BA, ACTN1, GP9, GP1BB, P2RY12, P2RX1, GP6
negative regulation of biological process (GO:0048519)	1.33	8	ITGB3, CD36, GP1BA, PLAU, GFI1B, ACTN1, MYH9, P2RY12
single-organism localization (GO:1902578)	2.09	8	ITGB3, ACTN1, ANO6, P2RY12, CD36, ITGA2B, MYH9, P2RX1
response to oxygen-containing compound (GO:1901700)	2.57	7	P2RY12, CD36, PLAU, TBXA2R, PRKACG, P2RX1, ITGA2
locomotion (GO:0040011)	2.91	7	ITGB3, ANO6, PLAU, P2RY12, MYH9, ITGA2, GP6
cellular response to stimulus (GO:0051716)	1.97	7	P2RY12, CD36, SLFN14, PRKACG, RASGRP2, PLAU, ITGA2
regulation of cellular component movement (GO:0051270)	3.08	7	ITGB3, ACTN1, ANO6, PLAU, P2RY12, ITGA2B, ITGA2
positive regulation of cellular metabolic process (GO:0031325)	1.81	7	ITGB3, CD36, PLAU, MYH9, PRKACG, P2RX1, ITGA2
positive regulation of metabolic process (GO:0009893)	1.74	7	ITGB3, CD36, PLAU, MYH9, PRKACG, P2RX1, ITGA2
cell motility (GO:0048870)	3.02	7	ITGB3, ANO6, PLAU, P2RY12, MYH9, ITGA2, GP6
protein metabolic process (GO:0019538)	1.45	7	CD36, GP1BA, GP9, PLAU, GP1BB, MYH9, PRKACG
positive regulation of multicellular organismal process (GO:0051240)	2.49	7	ITGB3, CD36, ANO6, PLAU, TBXAS1, TBXA2R, ITGA2
anatomical structure development (GO:0048856)	1.58	7	ITGB3, ANO6, PLAU, MYH9, GFI1B, PRKACG, ITGA2
regulation of response to stimulus (GO:0048583)	1.54	7	ITGB3, CD36, GP1BA, ANO6, PLAU, PRKACG, ITGA2
cellular metabolic process (GO:0044237)	0.69	7	GFI1B, CD36, PLAU, TBXAS1, PRKACG, P2RX1, SLFN14
movement of cell or subcellular component (GO:0006928)	2.61	7	ITGB3, ANO6, PLAU, P2RY12, MYH9, ITGA2, GP6
single-organism transport (GO:0044765)	2.18	7	ITGB3, ACTN1, ANO6, P2RY12, ITGA2B, P2RX1, CD36
negative regulation of cellular process (GO:0048523)	1.41	7	ITGB3, ACTN1, GP1BA, P2RY12, GFI1B, MYH9, CD36
positive regulation of molecular function (GO:0044093)	2.23	7	PRKACG, P2RY12, ITGB3, TBXA2R, RASGRP2, P2RX1, ITGA2
cell migration (GO:0016477)	3.12	7	ITGB3, ANO6, PLAU, P2RY12, MYH9, ITGA2, GP6
cellular response to chemical stimulus (GO:0070887)	2.57	7	P2RY12, CD36, SLFN14, PRKACG, RASGRP2, PLAU, ITGA2
response to organic substance (GO:0010033)	2.2	7	P2RY12, CD36, PLAU, TBXA2R, PRKACG, P2RX1, ITGA2
positive regulation of catalytic activity (GO:0043085)	2.4	7	PRKACG, P2RY12, ITGB3, TBXA2R, RASGRP2, P2RX1, ITGA2
response to endogenous stimulus (GO:0009719)	2.79	6	P2RY12, CD36, PLAU, PRKACG, P2RX1, ITGA2
immune system process (GO:0002376)	2.29	6	ITGB3, CD36, ANO6, MYH9, PRKACG, GP6
regulation of locomotion (GO:0040012)	3.12	6	ITGB3, ANO6, PLAU, P2RY12, ITGA2B, ITGA2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	ITGB3, CD36, MYH9, PRKACG, P2RX1, ITGA2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	6	ITGB3, CD36, MYH9, PRKACG, P2RX1, ITGA2
regulation of developmental process (GO:0050793)	2.1	6	P2RY12, CD36, ANO6, PLAU, MYH9, TBXA2R
regulation of transport (GO:0051049)	2.24	6	ITGB3, CD36, ANO6, P2RY12, P2RX1, ITGA2
regulation of response to stress (GO:0080134)	2.53	6	ANO6, GP1BA, PLAU, CD36, PRKACG, ITGA2
positive regulation of protein metabolic process (GO:0051247)	2.43	6	ITGB3, CD36, MYH9, PRKACG, P2RX1, ITGA2
regulation of cell migration (GO:0030334)	3.23	6	ITGB3, ANO6, PLAU, P2RY12, ITGA2B, ITGA2
regulation of cellular component organization (GO:0051128)	2.01	6	GFI1B, CD36, ANO6, MYH9, RASGRP2, ITGA2
homeostatic process (GO:0042592)	2.61	6	CD36, ANO6, PLAU, TBXA2R, PRKACG, TBXAS1
cellular component assembly (GO:0022607)	2.14	6	ITGB3, ANO6, ACTN1, P2RY12, P2RX1, ITGA2
regulation of immune system process (GO:0002682)	2.5	6	P2RY12, CD36, ANO6, ITGA2B, PRKACG, ITGA2
cellular developmental process (GO:0048869)	1.82	6	ITGB3, GP1BA, ACTN1, MYH9, NBEAL2, ITGA2
regulation of cell motility (GO:2000145)	3.16	6	ITGB3, ANO6, PLAU, P2RY12, ITGA2B, ITGA2
single organismal cell-cell adhesion (GO:0016337)	3.69	5	P2RY12, MYH9, ITGB3, ACTN1, ITGA2B
regulation of response to external stimulus (GO:0032101)	3.06	5	ITGA2, GP1BA, PLAU, ANO6, CD36
positive regulation of response to stimulus (GO:0048584)	2.18	5	ITGA2, ITGB3, PRKACG, ANO6, CD36
secretion by cell (GO:0032940)	3.59	5	ACTN1, ITGB3, ITGA2B, P2RX1, CD36
regulation of signaling (GO:0023051)	1.72	5	ITGA2, ITGB3, PLAU, GP1BA, CD36
regulation of phosphate metabolic process (GO:0019220)	2.35	5	ITGA2, PRKACG, ITGB3, GP1BA, CD36
anatomical structure morphogenesis (GO:0009653)	2.53	5	ITGA2, ITGB3, GP1BA, MYH9, ACTN1
response to organic cyclic compound (GO:0014070)	3.07	5	PLAU, P2RY12, ITGA2, P2RX1, CD36
regulation of cell communication (GO:0010646)	1.73	5	ITGA2, ITGB3, PLAU, GP1BA, CD36
positive regulation of hydrolase activity (GO:0051345)	2.91	5	TBXA2R, P2RX1, P2RY12, ITGA2, RASGRP2
platelet aggregation (GO:0070527)	6.04	5	P2RY12, MYH9, ITGB3, ACTN1, ITGA2B
cellular response to organic substance (GO:0071310)	2.78	5	PRKACG, PLAU, P2RY12, ITGA2, CD36
positive regulation of immune system process (GO:0002684)	2.96	5	ITGA2, PRKACG, ANO6, ITGA2B, CD36
regulation of protein modification process (GO:0031399)	2.32	5	PRKACG, ITGB3, GFI1B, GP1BA, CD36
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	5	NBEAL2, ITGB3, PLAU, MYH9, ACTN1
cellular homeostasis (GO:0019725)	3.23	5	TBXAS1, PLAU, TBXA2R, ANO6, CD36
positive regulation of cell migration (GO:0030335)	3.77	5	ITGA2, ITGB3, PLAU, ANO6, ITGA2B
single organism cell adhesion (GO:0098602)	3.63	5	P2RY12, MYH9, ITGB3, ACTN1, ITGA2B
positive regulation of transport (GO:0051050)	2.9	5	ITGA2, P2RY12, ANO6, P2RX1, CD36
cell-cell adhesion (GO:0098609)	3.34	5	P2RY12, MYH9, ITGB3, ACTN1, ITGA2B
homotypic cell-cell adhesion (GO:0034109)	5.76	5	ACTN1, ITGB3, P2RY12, MYH9, ITGA2B
regulation of biosynthetic process (GO:0009889)	1.37	5	GFI1B, ITGB3, ITGA2, ACTN1, CD36
regulation of phosphorus metabolic process (GO:0051174)	2.35	5	ITGA2, PRKACG, ITGB3, GP1BA, CD36
reproductive process (GO:0022414)	2.55	5	ITGA2, PRKACG, PLAU, MYH9, P2RX1
response to stress (GO:0006950)	1.8	5	ITGA2, TBXA2R, PLAU, ITGB3, CD36
cellular response to oxygen-containing compound (GO:1901701)	3.22	5	ITGA2, PLAU, P2RY12, PRKACG, CD36
system process (GO:0003008)	2.3	5	TBXAS1, TBXA2R, PRKACG, P2RX1, CD36
regulation of hydrolase activity (GO:0051336)	2.53	5	ITGA2, P2RY12, TBXA2R, P2RX1, RASGRP2
positive regulation of cellular component movement (GO:0051272)	3.71	5	ANO6, ITGB3, PLAU, ITGA2, ITGA2B
secretion (GO:0046903)	3.38	5	ACTN1, ITGB3, ITGA2B, P2RX1, CD36
positive regulation of locomotion (GO:0040017)	3.71	5	ITGA2, ITGB3, PLAU, ANO6, ITGA2B
response to organonitrogen compound (GO:0010243)	3.2	5	PRKACG, PLAU, P2RY12, ITGA2, P2RX1
chemical homeostasis (GO:0048878)	2.97	5	TBXAS1, TBXA2R, PLAU, PRKACG, CD36
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	5	GFI1B, ITGB3, ITGA2, ACTN1, CD36
positive regulation of cell motility (GO:2000147)	3.74	5	ITGA2, ITGB3, PLAU, ANO6, ITGA2B
cell differentiation (GO:0030154)	2.14	5	ITGA2, NBEAL2, MYH9, ITGB3, ACTN1
response to nitrogen compound (GO:1901698)	3.12	5	PRKACG, P2RY12, PLAU, ITGA2, P2RX1
negative regulation of metabolic process (GO:0009892)	1.93	4	ITGB3, GFI1B, GP1BA, CD36
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	TBXA2R, PLAU, MYH9, CD36
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	GFI1B, ITGA2, ACTN1, CD36
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	ITGB3, GFI1B, GP1BA, CD36
regulation of wound healing (GO:0061041)	4.88	4	PLAU, GP1BA, ANO6, CD36
intracellular signal transduction (GO:0035556)	2.39	4	TBXA2R, P2RY12, CD36, RASGRP2
regulated exocytosis (GO:0045055)	4.44	4	ITGB3, ACTN1, ITGA2B, CD36
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	GFI1B, ITGB3, GP1BA, CD36
cell morphogenesis (GO:0000902)	4.35	4	MYH9, ITGB3, GP1BA, ACTN1
cellular macromolecule metabolic process (GO:0044260)	0.93	4	GFI1B, SLFN14, PRKACG, CD36
regulation of signal transduction (GO:0009966)	1.84	4	ITGB3, PLAU, CD36, GP1BA
response to lipid (GO:0033993)	3.11	4	TBXA2R, PLAU, CD36, ITGA2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	ITGB3, PRKACG, ITGA2, CD36
exocytosis (GO:0006887)	4.11	4	ITGB3, ACTN1, ITGA2B, CD36
regulation of anatomical structure size (GO:0090066)	3.78	4	TBXAS1, TBXA2R, ANO6, P2RX1
regulation of hemostasis (GO:1900046)	5.26	4	PLAU, GP1BA, ANO6, CD36
regulation of leukocyte migration (GO:0002685)	4.72	4	ITGA2, P2RY12, ANO6, ITGA2B
extracellular structure organization (GO:0043062)	4.0	4	ITGB3, ITGA2, ITGA2B, CD36
regulation of response to wounding (GO:1903034)	4.74	4	PLAU, GP1BA, ANO6, CD36
regulation of gene expression (GO:0010468)	1.37	4	MYH9, GFI1B, ITGA2, CD36
cellular response to endogenous stimulus (GO:0071495)	3.33	4	PRKACG, P2RY12, PLAU, CD36
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	ITGB3, PRKACG, ITGA2, CD36
organic substance transport (GO:0071702)	2.15	4	MYH9, ANO6, P2RX1, CD36
regulation of system process (GO:0044057)	3.53	4	TBXAS1, TBXA2R, ITGA2, P2RX1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	GFI1B, ITGA2, ACTN1, CD36
cellular chemical homeostasis (GO:0055082)	3.4	4	TBXAS1, TBXA2R, PLAU, CD36
regulation of coagulation (GO:0050818)	5.22	4	PLAU, GP1BA, ANO6, CD36
multi-organism process (GO:0051704)	2.65	4	ITGB3, ITGA2, P2RX1, CD36
regulation of phosphorylation (GO:0042325)	2.5	4	ITGB3, PRKACG, GP1BA, CD36
vesicle-mediated transport (GO:0016192)	2.72	4	ITGB3, ACTN1, ITGA2B, CD36
response to external stimulus (GO:0009605)	2.55	4	TBXA2R, PLAU, ITGA2, CD36
integrin-mediated signaling pathway (GO:0007229)	5.17	4	MYH9, ITGB3, ITGA2, ITGA2B
leukocyte migration (GO:0050900)	4.19	4	ANO6, ITGB3, MYH9, GP6
extracellular matrix organization (GO:0030198)	4.01	4	ITGB3, ITGA2, ITGA2B, CD36
regulation of multicellular organismal development (GO:2000026)	2.31	4	TBXA2R, P2RY12, PLAU, ANO6
cellular component morphogenesis (GO:0032989)	3.5	4	MYH9, ITGB3, GP1BA, ACTN1
regulation of blood coagulation (GO:0030193)	5.26	4	PLAU, GP1BA, ANO6, CD36
regulation of protein phosphorylation (GO:0001932)	2.57	4	PRKACG, ITGB3, GP1BA, CD36
platelet degranulation (GO:0002576)	5.12	4	ITGB3, ACTN1, ITGA2B, CD36
blood coagulation, intrinsic pathway (GO:0007597)	6.84	3	GP9, GP1BB, GP1BA
platelet formation (GO:0030220)	6.84	3	MYH9, NBEAL2, ACTN1
positive regulation of defense response (GO:0031349)	3.83	3	PRKACG, CD36, ITGA2
circulatory system process (GO:0003013)	4.38	3	TBXA2R, TBXAS1, P2RX1
vascular process in circulatory system (GO:0003018)	4.65	3	TBXA2R, TBXAS1, P2RX1
regulation of defense response (GO:0031347)	3.11	3	PRKACG, CD36, ITGA2
single-organism metabolic process (GO:0044710)	1.63	3	TBXAS1, CD36, P2RX1
response to external biotic stimulus (GO:0043207)	3.13	3	TBXA2R, PLAU, CD36
response to wounding (GO:0009611)	4.39	3	ITGB3, PLAU, ITGA2
transmembrane transport (GO:0055085)	2.72	3	P2RY12, ANO6, P2RX1
purinergic receptor signaling pathway (GO:0035587)	6.4	3	P2RY12, ANO6, P2RX1
animal organ development (GO:0048513)	2.53	3	GFI1B, PRKACG, ITGA2
ion homeostasis (GO:0050801)	3.42	3	TBXA2R, TBXAS1, CD36
regulation of cell proliferation (GO:0042127)	2.41	3	ITGB3, PLAU, ITGA2
cell-substrate adhesion (GO:0031589)	4.75	3	ITGB3, ITGA2, ITGA2B
chemotaxis (GO:0006935)	4.04	3	ITGB3, PLAU, ANO6
negative regulation of transport (GO:0051051)	3.6	3	ITGB3, P2RY12, CD36
regulation of muscle contraction (GO:0006937)	4.75	3	TBXA2R, ITGA2, P2RX1
regulation of protein kinase activity (GO:0045859)	3.15	3	PRKACG, ITGB3, GP1BA
regulation of vasoconstriction (GO:0019229)	5.51	3	TBXA2R, TBXAS1, P2RX1
establishment of protein localization (GO:0045184)	2.53	3	MYH9, CD36, ITGA2
regulation of phagocytosis, engulfment (GO:0060099)	7.16	3	ITGA2, ANO6, CD36
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	GFI1B, CD36, ACTN1
positive regulation of signaling (GO:0023056)	2.41	3	ITGB3, CD36, ITGA2
positive regulation of phosphorylation (GO:0042327)	2.9	3	ITGB3, PRKACG, CD36
single organism reproductive process (GO:0044702)	2.73	3	PRKACG, MYH9, PLAU
response to biotic stimulus (GO:0009607)	3.09	3	TBXA2R, PLAU, CD36
cellular biosynthetic process (GO:0044249)	1.37	3	GFI1B, TBXAS1, P2RX1
positive regulation of cellular component organization (GO:0051130)	2.68	3	ITGA2, ANO6, CD36
negative regulation of biosynthetic process (GO:0009890)	2.47	3	ITGB3, GFI1B, CD36
inorganic ion homeostasis (GO:0098771)	3.43	3	TBXA2R, TBXAS1, CD36
nitrogen compound metabolic process (GO:0006807)	1.13	3	SLFN14, GFI1B, P2RX1
response to lipopolysaccharide (GO:0032496)	4.03	3	TBXA2R, PLAU, CD36
regulation of apoptotic process (GO:0042981)	2.5	3	ANO6, ACTN1, P2RX1
organic substance biosynthetic process (GO:1901576)	1.34	3	GFI1B, TBXAS1, P2RX1
cell morphogenesis involved in differentiation (GO:0000904)	4.67	3	ITGB3, MYH9, ACTN1
positive regulation of GTPase activity (GO:0043547)	3.28	3	TBXA2R, P2RY12, RASGRP2
regulation of kinase activity (GO:0043549)	3.07	3	PRKACG, ITGB3, GP1BA
positive regulation of leukocyte migration (GO:0002687)	5.05	3	ANO6, ITGA2, ITGA2B
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	3	TBXA2R, P2RY12, GP1BA
regulation of tube size (GO:0035150)	4.79	3	TBXA2R, TBXAS1, P2RX1
lipid metabolic process (GO:0006629)	2.68	3	TBXAS1, CD36, P2RX1
cation transport (GO:0006812)	3.11	3	P2RY12, ANO6, P2RX1
ion transport (GO:0006811)	2.66	3	P2RY12, ANO6, P2RX1
wound healing (GO:0042060)	5.13	3	ITGB3, PLAU, ITGA2
regulation of blood circulation (GO:1903522)	4.05	3	TBXA2R, TBXAS1, P2RX1
taxis (GO:0042330)	4.03	3	ITGB3, PLAU, ANO6
cellular response to nitrogen compound (GO:1901699)	3.79	3	PRKACG, P2RY12, PLAU
regulation of transferase activity (GO:0051338)	2.88	3	PRKACG, ITGB3, GP1BA
cell-matrix adhesion (GO:0007160)	5.13	3	ITGB3, ITGA2, ITGA2B
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	ITGB3, GFI1B, CD36
regulation of muscle system process (GO:0090257)	4.51	3	TBXA2R, ITGA2, P2RX1
regulation of cell adhesion (GO:0030155)	3.27	3	PLAU, CD36, ITGA2
positive regulation of membrane invagination (GO:1905155)	7.24	3	ANO6, ITGA2, CD36
regulation of smooth muscle contraction (GO:0006940)	5.63	3	TBXA2R, ITGA2, P2RX1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	SLFN14, GFI1B, P2RX1
cell-substrate junction assembly (GO:0007044)	5.99	3	ITGB3, ITGA2, ACTN1
regulation of membrane invagination (GO:1905153)	7.09	3	ANO6, ITGA2, CD36
positive regulation of cell communication (GO:0010647)	2.41	3	ITGB3, CD36, ITGA2
regulation of GTPase activity (GO:0043087)	3.21	3	TBXA2R, P2RY12, RASGRP2
positive regulation of phagocytosis (GO:0050766)	5.9	3	ITGA2, ANO6, CD36
regulation of phagocytosis (GO:0050764)	5.49	3	ITGA2, ANO6, CD36
regulation of blood vessel size (GO:0050880)	4.8	3	TBXA2R, TBXAS1, P2RX1
macromolecular complex subunit organization (GO:0043933)	2.14	3	GFI1B, ANO6, P2RX1
positive regulation of cell proliferation (GO:0008284)	3.01	3	ITGB3, PLAU, ITGA2
multicellular organismal reproductive process (GO:0048609)	3.35	3	PRKACG, PLAU, P2RX1
cellular response to lipid (GO:0071396)	3.96	3	PLAU, CD36, ITGA2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	GFI1B, CD36, ACTN1
regulation of vesicle-mediated transport (GO:0060627)	3.63	3	ITGA2, ANO6, CD36
positive regulation of ion transport (GO:0043270)	4.36	3	P2RY12, ANO6, P2RX1
regulation of cell differentiation (GO:0045595)	2.42	3	ITGB3, P2RY12, CD36
positive regulation of phagocytosis, engulfment (GO:0060100)	7.33	3	ITGA2, ANO6, CD36
cell junction assembly (GO:0034329)	4.86	3	ITGB3, ITGA2, ACTN1
positive regulation of developmental process (GO:0051094)	2.77	3	TBXA2R, CD36, ANO6
cellular response to organic cyclic compound (GO:0071407)	3.93	3	PLAU, P2RY12, ITGA2
regulation of RNA metabolic process (GO:0051252)	1.52	3	GFI1B, CD36, ACTN1
response to molecule of bacterial origin (GO:0002237)	3.99	3	TBXA2R, PLAU, CD36
myeloid cell differentiation (GO:0030099)	4.63	3	MYH9, NBEAL2, ACTN1
positive regulation of protein modification process (GO:0031401)	2.7	3	ITGB3, PRKACG, CD36
cell projection organization (GO:0030030)	3.14	3	MYH9, P2RY12, ANO6
cell junction organization (GO:0034330)	4.51	3	ITGB3, ITGA2, ACTN1
angiogenesis (GO:0001525)	4.15	3	ITGB3, MYH9, PLAU
regulation of ion transport (GO:0043269)	3.4	3	P2RY12, ANO6, P2RX1
regulation of cell death (GO:0010941)	2.43	3	ANO6, ACTN1, P2RX1
protein activation cascade (GO:0072376)	5.21	3	GP9, GP1BB, GP1BA
cellular response to organonitrogen compound (GO:0071417)	3.87	3	PRKACG, P2RY12, PLAU
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	GFI1B, CD36, ITGA2
regulation of programmed cell death (GO:0043067)	2.49	3	ANO6, ACTN1, P2RX1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	GFI1B, CD36, ACTN1
regulation of metal ion transport (GO:0010959)	3.94	3	P2RY12, ANO6, P2RX1
ion transmembrane transport (GO:0034220)	3.08	3	P2RY12, ANO6, P2RX1
biosynthetic process (GO:0009058)	1.32	3	GFI1B, TBXAS1, P2RX1
cellular ion homeostasis (GO:0006873)	3.57	3	TBXA2R, TBXAS1, CD36
regulation of endocytosis (GO:0030100)	4.42	3	ANO6, ITGA2, CD36
purinergic nucleotide receptor signaling pathway (GO:0035590)	6.64	3	P2RY12, ANO6, P2RX1
positive regulation of endocytosis (GO:0045807)	4.98	3	ITGA2, ANO6, CD36
cation transmembrane transport (GO:0098655)	3.43	3	P2RY12, ANO6, P2RX1
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	ITGB3, PRKACG, CD36
protein localization (GO:0008104)	2.36	2	MYH9, CD36
cellular cation homeostasis (GO:0030003)	3.6	2	TBXA2R, CD36
negative regulation of response to stimulus (GO:0048585)	2.52	2	PLAU, GP1BA
activation of protein kinase activity (GO:0032147)	4.08	2	PRKACG, ITGB3
regulation of homeostatic process (GO:0032844)	3.65	2	ITGB3, CD36
membrane organization (GO:0061024)	3.04	2	MYH9, ANO6
positive regulation of vasoconstriction (GO:0045907)	6.12	2	TBXA2R, TBXAS1
regulation of chemotaxis (GO:0050920)	4.53	2	ANO6, ITGA2
positive regulation of chemotaxis (GO:0050921)	4.94	2	ANO6, ITGA2
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	ITGB3, GP6
negative regulation of response to external stimulus (GO:0032102)	4.18	2	PLAU, GP1BA
positive regulation of smooth muscle contraction (GO:0045987)	6.29	2	TBXA2R, ITGA2
organic cyclic compound metabolic process (GO:1901360)	1.26	2	SLFN14, GFI1B
single-organism biosynthetic process (GO:0044711)	2.8	2	TBXAS1, P2RX1
positive regulation of cell adhesion (GO:0045785)	3.79	2	CD36, ITGA2
positive regulation of signal transduction (GO:0009967)	2.5	2	ITGB3, CD36
interspecies interaction between organisms (GO:0044419)	3.08	2	ITGB3, ITGA2
macromolecule localization (GO:0033036)	2.34	2	MYH9, CD36
response to activity (GO:0014823)	5.47	2	PLAU, ITGA2
spermatogenesis (GO:0007283)	3.7	2	PRKACG, PLAU
regulation of proteolysis (GO:0030162)	3.2	2	MYH9, P2RX1
response to metal ion (GO:0010038)	3.91	2	SLFN14, RASGRP2
divalent inorganic cation transport (GO:0072511)	4.13	2	P2RY12, ANO6
interaction with host (GO:0051701)	4.86	2	ITGB3, ITGA2
response to inorganic substance (GO:0010035)	3.56	2	SLFN14, RASGRP2
heterocycle metabolic process (GO:0046483)	1.31	2	SLFN14, GFI1B
positive regulation of epithelial cell migration (GO:0010634)	5.09	2	ITGB3, ITGA2
multi-organism reproductive process (GO:0044703)	4.82	2	ITGA2, P2RX1
regulation of epithelial cell migration (GO:0010632)	4.62	2	ITGB3, ITGA2
multi-multicellular organism process (GO:0044706)	4.92	2	ITGA2, P2RX1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	2	ITGB3, CD36
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	2	ITGB3, CD36
response to monosaccharide (GO:0034284)	4.77	2	PLAU, ITGA2
calcium ion transmembrane transport (GO:0070588)	4.67	2	P2RY12, ANO6
response to nutrient levels (GO:0031667)	3.77	2	TBXA2R, ITGA2
response to organophosphorus (GO:0046683)	4.79	2	P2RY12, P2RX1
regulation of lipid storage (GO:0010883)	6.02	2	ITGB3, CD36
cellular response to stress (GO:0033554)	2.51	2	PLAU, CD36
negative regulation of blood coagulation (GO:0030195)	5.88	2	PLAU, GP1BA
calcium ion homeostasis (GO:0055074)	3.97	2	TBXA2R, CD36
viral entry into host cell (GO:0046718)	5.35	2	ITGB3, ITGA2
organic hydroxy compound transport (GO:0015850)	4.96	2	CD36, P2RX1
muscle cell migration (GO:0014812)	6.84	2	ITGB3, PLAU
positive regulation of immune response (GO:0050778)	3.4	2	PRKACG, CD36
positive regulation of coagulation (GO:0050820)	6.51	2	CD36, ANO6
negative regulation of gene expression (GO:0010629)	2.48	2	GFI1B, CD36
positive regulation of gene expression (GO:0010628)	2.35	2	MYH9, ITGA2
second-messenger-mediated signaling (GO:0019932)	4.65	2	TBXA2R, CD36
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	GFI1B, CD36
activation of immune response (GO:0002253)	3.67	2	PRKACG, CD36
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	GFI1B, CD36
positive regulation of transferase activity (GO:0051347)	3.31	2	PRKACG, ITGB3
immune response-regulating signaling pathway (GO:0002764)	3.72	2	PRKACG, CD36
entry into other organism involved in symbiotic interaction (GO:0051828)	5.3	2	ITGB3, ITGA2
macromolecular complex assembly (GO:0065003)	2.55	2	ANO6, P2RX1
negative regulation of hemostasis (GO:1900047)	5.88	2	PLAU, GP1BA
inorganic cation transmembrane transport (GO:0098662)	3.55	2	P2RY12, ANO6
cellular response to molecule of bacterial origin (GO:0071219)	4.88	2	PLAU, CD36
inorganic ion transmembrane transport (GO:0098660)	3.38	2	P2RY12, ANO6
cellular response to biotic stimulus (GO:0071216)	4.76	2	PLAU, CD36
positive regulation of hemostasis (GO:1900048)	6.55	2	CD36, ANO6
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	2	PLAU, CD36
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	TBXA2R, CD36
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	2	PLAU, CD36
tissue development (GO:0009888)	3.27	2	PLAU, ANO6
defense response (GO:0006952)	2.78	2	TBXA2R, CD36
regulation of multi-organism process (GO:0043900)	3.6	2	PLAU, CD36
regulation of intracellular signal transduction (GO:1902531)	2.31	2	CD36, GP1BA
negative regulation of coagulation (GO:0050819)	5.82	2	PLAU, GP1BA
RNA metabolic process (GO:0016070)	1.59	2	SLFN14, GFI1B
fibrinolysis (GO:0042730)	6.68	2	PLAU, GP1BA
immune response-activating signal transduction (GO:0002757)	3.8	2	PRKACG, CD36
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	GFI1B, P2RX1
response to decreased oxygen levels (GO:0036293)	4.09	2	PLAU, ITGA2
innate immune response-activating signal transduction (GO:0002758)	4.45	2	PRKACG, CD36
positive regulation of blood circulation (GO:1903524)	5.16	2	TBXA2R, TBXAS1
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	GFI1B, CD36
positive regulation of smooth muscle cell migration (GO:0014911)	6.33	2	PLAU, ITGA2
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	GFI1B, CD36
positive regulation of blood coagulation (GO:0030194)	6.55	2	CD36, ANO6
positive regulation of kinase activity (GO:0033674)	3.54	2	ITGB3, PRKACG
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	TBXA2R, CD36
cellular response to metal ion (GO:0071248)	4.81	2	SLFN14, RASGRP2
positive regulation of response to external stimulus (GO:0032103)	4.17	2	ANO6, ITGA2
lipid transport (GO:0006869)	4.24	2	CD36, ANO6
phosphorylation (GO:0016310)	2.63	2	PRKACG, PLAU
cellular response to inorganic substance (GO:0071241)	4.67	2	SLFN14, RASGRP2
regulation of smooth muscle cell migration (GO:0014910)	5.84	2	PLAU, ITGA2
entry into host cell (GO:0030260)	5.3	2	ITGB3, ITGA2
cell-substrate adherens junction assembly (GO:0007045)	6.55	2	ACTN1, ITGA2
response to purine-containing compound (GO:0014074)	4.67	2	P2RY12, P2RX1
response to hypoxia (GO:0001666)	4.13	2	PLAU, ITGA2
nucleobase-containing compound metabolic process (GO:0006139)	1.35	2	SLFN14, GFI1B
negative regulation of protein metabolic process (GO:0051248)	2.82	2	ITGB3, GP1BA
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	TBXA2R, CD36
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	GFI1B, CD36
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	PLAU, GP1BA
adherens junction assembly (GO:0034333)	6.2	2	ITGA2, ACTN1
adherens junction organization (GO:0034332)	5.48	2	ITGA2, ACTN1
proteolysis (GO:0006508)	2.73	2	MYH9, PLAU
response to oxygen levels (GO:0070482)	4.02	2	PLAU, ITGA2
negative regulation of response to wounding (GO:1903035)	5.54	2	PLAU, GP1BA
positive regulation of response to wounding (GO:1903036)	5.76	2	CD36, ANO6
smooth muscle cell migration (GO:0014909)	7.65	2	ITGB3, PLAU
cell proliferation (GO:0008283)	3.23	2	GFI1B, ITGA2
cellular metal ion homeostasis (GO:0006875)	3.75	2	TBXA2R, CD36
cellular calcium ion homeostasis (GO:0006874)	4.01	2	TBXA2R, CD36
cellular aromatic compound metabolic process (GO:0006725)	1.3	2	SLFN14, GFI1B
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	GFI1B, CD36
negative regulation of cell differentiation (GO:0045596)	3.33	2	ITGB3, P2RY12
metal ion transport (GO:0030001)	3.36	2	P2RY12, ANO6
response to acid chemical (GO:0001101)	4.05	2	CD36, ITGA2
cell-cell junction organization (GO:0045216)	4.66	2	ITGA2, ACTN1
male gamete generation (GO:0048232)	3.7	2	PRKACG, PLAU
cation homeostasis (GO:0055080)	3.46	2	TBXA2R, CD36
cellular lipid metabolic process (GO:0044255)	2.92	2	TBXAS1, P2RX1
regulation of immune response (GO:0050776)	2.98	2	PRKACG, CD36
divalent metal ion transport (GO:0070838)	4.15	2	P2RY12, ANO6
response to hormone (GO:0009725)	3.33	2	PRKACG, ITGA2
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	GFI1B, CD36
response to drug (GO:0042493)	3.71	2	TBXA2R, ITGA2
regulation of cell-matrix adhesion (GO:0001952)	5.21	2	PLAU, CD36
monovalent inorganic cation transport (GO:0015672)	3.74	2	P2RY12, ANO6
calcium ion transport (GO:0006816)	4.33	2	P2RY12, ANO6
positive regulation of proteolysis (GO:0045862)	3.86	2	MYH9, P2RX1
response to ATP (GO:0033198)	6.33	2	P2RY12, P2RX1
positive regulation of protein kinase activity (GO:0045860)	3.61	2	PRKACG, ITGB3
response to extracellular stimulus (GO:0009991)	3.71	2	TBXA2R, ITGA2
cellular response to lipopolysaccharide (GO:0071222)	4.94	2	PLAU, CD36
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	GFI1B, CD36
cell projection assembly (GO:0030031)	4.19	2	P2RY12, ANO6
positive regulation of wound healing (GO:0090303)	5.88	2	CD36, ANO6
nucleic acid metabolic process (GO:0090304)	1.46	2	SLFN14, GFI1B
regulation of blood pressure (GO:0008217)	4.72	2	TBXA2R, P2RX1
negative regulation of wound healing (GO:0061045)	5.65	2	PLAU, GP1BA
focal adhesion assembly (GO:0048041)	6.55	2	ITGA2, ACTN1
positive regulation of cell death (GO:0010942)	3.32	2	ANO6, P2RX1
cell death (GO:0008219)	3.05	2	PLAU, P2RX1
multicellular organism development (GO:0007275)	2.54	2	MYH9, GFI1B
gamete generation (GO:0007276)	3.61	2	PRKACG, PLAU
growth (GO:0040007)	3.8	2	ITGB3, PLAU
protein complex subunit organization (GO:0071822)	2.6	2	ANO6, P2RX1
activation of innate immune response (GO:0002218)	4.41	2	PRKACG, CD36
regulation of growth (GO:0040008)	3.26	2	CD36, RASGRP2
mesodermal cell differentiation (GO:0048333)	7.09	2	ITGB3, ITGA2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	GFI1B, CD36
positive regulation of apoptotic process (GO:0043065)	3.38	2	ANO6, P2RX1
positive regulation of programmed cell death (GO:0043068)	3.38	2	ANO6, P2RX1
regulation of macrophage derived foam cell differentiation (GO:0010743)	6.4	2	ITGB3, CD36
positive regulation of muscle contraction (GO:0045933)	5.9	2	TBXA2R, ITGA2
positive regulation of innate immune response (GO:0045089)	4.22	2	PRKACG, CD36
regulation of innate immune response (GO:0045088)	3.86	2	PRKACG, CD36
regulation of cell-substrate adhesion (GO:0010810)	4.56	2	PLAU, CD36
response to nutrient (GO:0007584)	4.49	2	TBXA2R, ITGA2
protein complex assembly (GO:0006461)	2.78	2	ANO6, P2RX1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	GFI1B, CD36
multi-organism cellular process (GO:0044764)	3.14	2	ITGB3, ITGA2
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	GFI1B, CD36
metal ion homeostasis (GO:0055065)	3.61	2	TBXA2R, CD36
lipid biosynthetic process (GO:0008610)	3.49	2	TBXAS1, P2RX1
response to abiotic stimulus (GO:0009628)	2.8	2	PLAU, ITGA2
response to carbohydrate (GO:0009743)	4.62	2	PLAU, ITGA2
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	TBXA2R, CD36
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	ITGB3, PLAU
regulation of calcium ion transport (GO:0051924)	4.38	2	P2RY12, P2RX1
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	PRKACG, PLAU
entry into host (GO:0044409)	5.3	2	ITGB3, ITGA2
viral process (GO:0016032)	3.15	2	ITGB3, ITGA2
phosphorus metabolic process (GO:0006793)	2.15	2	PRKACG, PLAU
protein transport (GO:0015031)	2.62	2	MYH9, CD36
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	ITGB3, ITGA2
entry into cell of other organism involved in symbiotic interaction (GO:0051806)	5.3	2	ITGB3, ITGA2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.0	GFI1B, ACTN1, GP1BA, GP9, ANO6, PLAU, ITGB3, ITGA2B, TBXA2R, MYH9, CD36, TBXAS1, ITGA2
negative regulation of phosphorus metabolic process (GO:0010563)	NEW	3.45	0.044	PRKACG, GFI1B, ITGB3, GP1BA, TBXA2R, MYH9, CD36, ITGA2
hemostasis (GO:0007599)	-	4.5	0.0	PRKACG, GFI1B, ANO6, ACTN1, GP9, PLAU, GP1BB, MYH9, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, CD36, NBEAL2, GP1BA, ITGB3, RASGRP2
regulation of phagocytosis, engulfment (GO:0060099)	-	7.16	0.023	CD36, ITGA2
regulation of cellular localization (GO:0060341)	NEW	3.03	0.023	PRKACG, GFI1B, P2RY12, ACTN1, PLAU, ITGB3, ITGA2B, TBXA2R, MYH9, GP6, CD36, ITGA2
regulation of response to external stimulus (GO:0032101)	-	3.06	0.003	ITGB3, ACTN1, GP1BA, GP9, ANO6, PLAU, GFI1B, MYH9, GP6, CD36, ITGA2
regulation of smooth muscle cell migration (GO:0014910)	-	5.84	0.004	ITGB3, PLAU, ITGA2, CD36
blood coagulation, intrinsic pathway (GO:0007597)	-	6.84	0.001	GP9, GP1BB, GP1BA
blood coagulation (GO:0007596)	-	4.52	0.0	PRKACG, GFI1B, ANO6, ACTN1, GP9, PLAU, GP1BB, MYH9, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, CD36, NBEAL2, GP1BA, ITGB3, RASGRP2
regulation of vasoconstriction (GO:0019229)	-	5.51	0.026	TBXAS1, TBXA2R, ACTN1, P2RX1
regulation of smooth muscle contraction (GO:0006940)	-	5.63	0.024	TBXA2R, ITGA2, P2RX1
regulation of wound healing (GO:0061041)	-	4.88	0.0	ITGB3, ANO6, GP1BA, PLAU, CD36, ACTN1, MYH9
smooth muscle cell migration (GO:0014909)	-	7.65	0.023	ITGB3, PLAU
cell surface receptor signaling pathway (GO:0007166)	-	2.09	0.014	PRKACG, ITGB3, CD36, GP1BA, P2RY12, GP1BB, TBXA2R, ITGA2B, MYH9, GP6, P2RX1, ITGA2
angiogenesis (GO:0001525)	-	4.15	0.038	GFI1B, ACTN1, PLAU, ITGB3, MYH9, GP6, ITGA2
negative regulation of protein metabolic process (GO:0051248)	-	2.82	0.027	GFI1B, GP1BA, ACTN1, PLAU, TBXA2R, ITGA2B, MYH9, CD36, ITGB3, ITGA2
regulation of nucleoside metabolic process (GO:0009118)	NEW	5.82	0.046	PRKACG, GFI1B, ITGB3, ACTN1, P2RY12, TBXA2R, MYH9, ITGA2, RASGRP2
positive regulation of hydrolase activity (GO:0051345)	-	2.91	0.026	PRKACG, GFI1B, ITGB3, ACTN1, PLAU, TBXA2R, MYH9, P2RY12, ITGA2, P2RX1, RASGRP2
response to nitrogen compound (GO:1901698)	-	3.12	0.014	PRKACG, GFI1B, ITGB3, GP1BA, TBXA2R, ITGA2B, ACTN1, MYH9, P2RX1, CD36, ITGA2
platelet degranulation (GO:0002576)	-	5.12	0.001	ITGB3, ACTN1, ITGA2B, CD36
regulation of muscle contraction (GO:0006937)	-	4.75	0.037	ACTN1, MYH9, TBXA2R, ITGA2, P2RX1
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.006	PRKACG, GFI1B, GP1BA, ACTN1, GP9, PLAU, MYH9, ITGA2B, TBXA2R, GP6, CD36, ITGB3, ITGA2
regulation of hemostasis (GO:1900046)	-	5.26	0.001	ITGB3, ANO6, GP1BA, PLAU, CD36, MYH9
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.022	PRKACG, GFI1B, ITGB3, GP1BA, PLAU, TBXA2R, ITGA2B, ACTN1, MYH9, GP6, CD36, ITGA2
regulation of kinase activity (GO:0043549)	-	3.07	0.014	PRKACG, GFI1B, ACTN1, GP1BA, PLAU, TBXA2R, MYH9, GP6, CD36, ITGB3, ITGA2
negative regulation of phosphate metabolic process (GO:0045936)	NEW	3.45	0.044	PRKACG, GFI1B, ITGB3, GP1BA, TBXA2R, MYH9, CD36, ITGA2
homotypic cell-cell adhesion (GO:0034109)	-	5.76	0.001	ITGB3, PLAU, P2RY12, MYH9, ITGA2B
biological regulation (GO:0065007)	-	0.39	0.04	PRKACG, GFI1B, ANO6, ACTN1, GP9, PLAU, GP1BB, TBXAS1, ITGA2B, ITGA2, TBXA2R, P2RY12, MYH9, P2RX1, CD36, NBEAL2, GP6, GP1BA, ITGB3, RASGRP2
biological adhesion (GO:0022610)	-	2.81	0.0	ITGB3, ACTN1, GP1BA, GP9, PLAU, GP1BB, GFI1B, ITGA2B, MYH9, P2RY12, GP6, CD36, ITGA2
regulation of response to wounding (GO:1903034)	-	4.74	0.023	ITGB3, ACTN1, GP1BA, ANO6, PLAU, CD36, MYH9, ITGA2
cell-substrate adhesion (GO:0031589)	-	4.75	0.008	GFI1B, ACTN1, PLAU, ITGB3, ITGA2B, ITGA2
multicellular organismal process (GO:0032501)	-	1.45	0.0	PRKACG, GFI1B, CD36, ACTN1, GP9, ANO6, PLAU, GP1BB, ITGB3, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, NBEAL2, GP1BA, RASGRP2
regulation of body fluid levels (GO:0050878)	-	3.76	0.0	PRKACG, GFI1B, ANO6, ACTN1, GP9, PLAU, GP1BB, MYH9, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, CD36, NBEAL2, GP1BA, ITGB3, RASGRP2
positive regulation of transport (GO:0051050)	-	2.9	0.013	GFI1B, P2RY12, ACTN1, PLAU, ITGB3, ITGA2B, MYH9, GP6, P2RX1, CD36, ITGA2
positive regulation of cell-substrate adhesion (GO:0010811)	NEW	5.11	0.016	ITGA2, ITGB3, PLAU, CD36, ACTN1
innate immune response (GO:0045087)	NEW	3.55	0.025	PRKACG, ITGB3, GP1BA, ACTN1, GP9, PLAU, GFI1B, MYH9, CD36, GP6
regulation of protein kinase activity (GO:0045859)	-	3.15	0.008	PRKACG, GFI1B, ACTN1, GP1BA, PLAU, TBXA2R, MYH9, GP6, CD36, ITGB3, ITGA2
secretion (GO:0046903)	-	3.38	0.007	GFI1B, ITGB3, ACTN1, PLAU, TBXA2R, ITGA2B, MYH9, P2RX1, CD36, GP6
leukocyte migration (GO:0050900)	-	4.19	0.0	ITGB3, ANO6, CD36, PLAU, ITGA2B, MYH9, GP6, ITGA2
cell activation (GO:0001775)	-	3.47	0.0	ITGB3, ACTN1, CD36, GP9, PLAU, GP1BB, MYH9, ITGA2B, ITGA2, TBXA2R, P2RY12, GP6, P2RX1, GP1BA, RASGRP2
coagulation (GO:0050817)	-	4.51	0.0	PRKACG, GFI1B, GP1BA, ACTN1, GP9, ANO6, PLAU, GP1BB, MYH9, ITGA2B, TBXA2R, P2RY12, ITGA2, P2RX1, CD36, NBEAL2, GP6, ITGB3, RASGRP2
single-organism cellular process (GO:0044763)	-	0.65	0.037	PRKACG, ANO6, ITGB3, GP1BA, ACTN1, GP9, MYH9, PLAU, GP1BB, TBXA2R, ITGA2B, TBXAS1, P2RY12, ITGA2, P2RX1, CD36, GP6, NBEAL2, RASGRP2
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.025	GFI1B, CD36, GP1BA, ANO6, PLAU, ITGB3, TBXA2R, P2RX1, TBXAS1, ITGA2
cell adhesion (GO:0007155)	-	2.82	0.0	GFI1B, GP1BA, ACTN1, GP9, PLAU, GP1BB, ITGB3, ITGA2B, MYH9, P2RY12, GP6, CD36, ITGA2
positive regulation of phagocytosis, engulfment (GO:0060100)	-	7.33	0.011	CD36, ITGA2
regulation of localization (GO:0032879)	-	1.94	0.008	ITGB3, ACTN1, ANO6, PLAU, CD36, ITGA2B, PRKACG, P2RY12, P2RX1, ITGA2
regulation of coagulation (GO:0050818)	-	5.22	0.0	ITGB3, ANO6, GP1BA, PLAU, CD36, MYH9
platelet activation (GO:0030168)	-	4.96	0.0	ITGB3, ACTN1, GP1BA, GP9, P2RY12, GP1BB, CD36, ITGA2B, TBXA2R, RASGRP2, P2RX1, GP6, ITGA2
negative regulation of cellular protein metabolic process (GO:0032269)	NEW	2.88	0.005	GFI1B, GP1BA, ACTN1, PLAU, TBXA2R, ITGA2B, MYH9, CD36, ITGB3, ITGA2
regulation of purine nucleotide metabolic process (GO:1900542)	NEW	4.41	0.028	PRKACG, GFI1B, ITGB3, ACTN1, PLAU, TBXA2R, MYH9, P2RY12, ITGA2, RASGRP2
regulation of biological quality (GO:0065008)	-	1.68	0.0	PRKACG, ITGB3, ANO6, ACTN1, GP9, PLAU, GP1BB, TBXA2R, ITGA2B, ITGA2, TBXAS1, P2RY12, MYH9, P2RX1, CD36, GP6, GP1BA, NBEAL2, RASGRP2
single-multicellular organism process (GO:0044707)	-	1.78	0.0	PRKACG, GFI1B, GP1BA, ANO6, ITGA2, PLAU, GP1BB, ITGB3, ITGA2B, ACTN1, GP9, TBXA2R, P2RY12, GP6, P2RX1, CD36, NBEAL2, RASGRP2
membrane organization (GO:0061024)	-	3.04	0.03	GFI1B, ITGB3, ACTN1, ANO6, PLAU, TBXA2R, MYH9, ITGA2, GP6
response to hormone (GO:0009725)	-	3.33	0.02	PRKACG, GFI1B, ITGB3, GP1BA, PLAU, TBXA2R, ITGA2B, ACTN1, MYH9, CD36, ITGA2
integrin-mediated signaling pathway (GO:0007229)	-	5.17	0.002	MYH9, ITGB3, ITGA2, ITGA2B
secretion by cell (GO:0032940)	-	3.59	0.001	ITGB3, CD36, ACTN1, PLAU, TBXA2R, ITGA2B, GFI1B, MYH9, P2RX1, GP6
regulation of transferase activity (GO:0051338)	-	2.88	0.036	PRKACG, GFI1B, ITGB3, GP1BA, PLAU, TBXA2R, ACTN1, MYH9, GP6, CD36, ITGA2
platelet aggregation (GO:0070527)	-	6.04	0.0	P2RY12, ACTN1, PLAU, ITGB3, ITGA2B, MYH9
regulation of blood coagulation (GO:0030193)	-	5.26	0.001	ITGB3, ANO6, GP1BA, PLAU, CD36, MYH9
regulation of nucleotide metabolic process (GO:0006140)	NEW	4.38	0.03	PRKACG, GFI1B, ITGB3, ACTN1, PLAU, TBXA2R, MYH9, P2RY12, ITGA2, RASGRP2
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.023	PRKACG, GFI1B, ITGB3, GP1BA, PLAU, TBXA2R, ITGA2B, ACTN1, MYH9, GP6, CD36, ITGA2
response to organonitrogen compound (GO:0010243)	-	3.2	0.007	PRKACG, GFI1B, GP1BA, ACTN1, TBXA2R, ITGA2B, MYH9, P2RX1, CD36, ITGB3, ITGA2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	21	PRKACG, ANO6, GFI1B, ACTN1, GP1BA, GP9, MYH9, SLFN14, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RY12, ITGA2, P2RX1, CD36, GP6, TBXAS1, NBEAL2, PLAU, RASGRP2
membrane (GO:0016020)	0.68	18	ITGB3, ANO6, ACTN1, GP9, PLAU, GP1BB, TBXA2R, ITGA2B, ITGA2, TBXAS1, P2RY12, MYH9, P2RX1, CD36, GP6, GP1BA, NBEAL2, RASGRP2
intracellular part (GO:0044424)	0.28	16	PRKACG, GFI1B, GP1BA, ACTN1, MYH9, SLFN14, TBXAS1, ITGA2B, TBXA2R, P2RY12, ITGA2, P2RX1, CD36, NBEAL2, ITGB3, RASGRP2
membrane part (GO:0044425)	0.95	16	ITGB3, GP1BA, ANO6, ITGA2, P2RY12, GP1BB, TBXA2R, ITGA2B, GP9, TBXAS1, MYH9, P2RX1, CD36, GP6, NBEAL2, RASGRP2
membrane-bounded organelle (GO:0043227)	0.47	16	GFI1B, GP1BA, ACTN1, ANO6, SLFN14, TBXA2R, ITGA2B, TBXAS1, P2RY12, MYH9, GP6, CD36, NBEAL2, PLAU, ITGB3, ITGA2
organelle (GO:0043226)	0.4	16	GFI1B, GP1BA, ACTN1, ANO6, SLFN14, TBXA2R, ITGA2B, TBXAS1, P2RY12, MYH9, GP6, CD36, NBEAL2, PLAU, ITGB3, ITGA2
plasma membrane (GO:0005886)	1.39	16	ITGB3, ACTN1, GP1BA, GP9, ANO6, PLAU, GP1BB, MYH9, ITGA2B, TBXA2R, P2RY12, RASGRP2, P2RX1, CD36, GP6, ITGA2
integral component of membrane (GO:0016021)	1.14	13	ITGB3, GP1BA, ANO6, GP9, P2RY12, GP1BB, TBXAS1, ITGA2B, TBXA2R, ITGA2, P2RX1, CD36, GP6
plasma membrane part (GO:0044459)	1.95	13	ITGB3, CD36, GP1BA, GP9, P2RY12, GP1BB, TBXA2R, ITGA2B, MYH9, RASGRP2, P2RX1, GP6, ITGA2
intrinsic component of membrane (GO:0031224)	1.13	13	ITGB3, CD36, GP1BA, GP9, ANO6, P2RY12, GP1BB, TBXAS1, ITGA2B, TBXA2R, GP6, P2RX1, ITGA2
cytoplasmic part (GO:0044444)	0.82	12	PRKACG, ITGB3, CD36, ACTN1, MYH9, P2RY12, TBXA2R, ITGA2B, TBXAS1, RASGRP2, NBEAL2, ITGA2
intracellular organelle (GO:0043229)	0.51	11	GFI1B, ITGB3, ACTN1, SLFN14, TBXA2R, TBXAS1, P2RY12, MYH9, CD36, NBEAL2, ITGA2
intracellular membrane-bounded organelle (GO:0043231)	0.6	10	GFI1B, P2RY12, CD36, SLFN14, ITGB3, TBXA2R, MYH9, TBXAS1, NBEAL2, ITGA2
intrinsic component of plasma membrane (GO:0031226)	2.53	10	P2RY12, CD36, GP1BA, GP9, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RX1, GP6
vesicle (GO:0031982)	1.64	10	ITGB3, GP1BA, ANO6, PLAU, TBXA2R, ITGA2B, ACTN1, MYH9, CD36, GP6
integral component of plasma membrane (GO:0005887)	2.57	10	ITGB3, CD36, GP1BA, GP9, GP1BB, P2RY12, ITGA2B, TBXA2R, P2RX1, GP6
membrane-bounded vesicle (GO:0031988)	1.71	10	ITGB3, GP1BA, ANO6, PLAU, TBXA2R, ITGA2B, ACTN1, MYH9, CD36, GP6
intracellular organelle part (GO:0044446)	0.81	9	PRKACG, ITGB3, CD36, ACTN1, GFI1B, ITGA2B, MYH9, P2RX1, TBXAS1
cell surface (GO:0009986)	3.44	9	ITGB3, GP1BA, ANO6, PLAU, CD36, ITGA2B, P2RY12, ITGA2, GP6
extracellular region part (GO:0044421)	1.57	9	ITGB3, GP1BA, ANO6, PLAU, CD36, ITGA2B, ACTN1, MYH9, GP6
organelle part (GO:0044422)	0.79	9	PRKACG, ITGB3, CD36, ACTN1, GFI1B, ITGA2B, MYH9, P2RX1, TBXAS1
protein complex (GO:0043234)	1.51	8	ITGB3, CD36, ANO6, GFI1B, ITGA2B, MYH9, P2RX1, ITGA2
macromolecular complex (GO:0032991)	1.35	8	ITGB3, CD36, ANO6, GFI1B, ITGA2B, MYH9, P2RX1, ITGA2
extracellular vesicle (GO:1903561)	1.89	8	ITGB3, GP1BA, ANO6, PLAU, ITGA2B, ACTN1, MYH9, GP6
extracellular organelle (GO:0043230)	1.89	8	ITGB3, GP1BA, ACTN1, ANO6, PLAU, ITGA2B, MYH9, GP6
extracellular exosome (GO:0070062)	1.89	8	ITGB3, GP1BA, ANO6, PLAU, ITGA2B, ACTN1, MYH9, GP6
cell junction (GO:0030054)	2.75	7	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, RASGRP2, ITGA2
focal adhesion (GO:0005925)	3.83	6	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
cytosol (GO:0005829)	1.68	6	CD36, ACTN1, MYH9, PRKACG, TBXA2R, RASGRP2
anchoring junction (GO:0070161)	3.61	6	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
adherens junction (GO:0005912)	3.66	6	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
cell-substrate adherens junction (GO:0005924)	3.83	6	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
cell projection (GO:0042995)	2.47	6	ITGB3, ACTN1, MYH9, RASGRP2, P2RX1, ITGA2
cell-substrate junction (GO:0030055)	3.82	6	ITGB3, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
cytoplasm (GO:0005737)	1.01	5	MYH9, SLFN14, GP1BA, ACTN1, RASGRP2
plasma membrane region (GO:0098590)	2.97	5	ITGB3, P2RY12, P2RX1, RASGRP2, CD36
nucleus (GO:0005634)	1.07	5	GFI1B, SLFN14, ITGB3, MYH9, ITGA2
cell projection part (GO:0044463)	2.97	5	ITGA2, ITGB3, PRKACG, RASGRP2, CD36
membrane protein complex (GO:0098796)	2.84	5	ITGA2, ANO6, ITGB3, MYH9, ITGA2B
side of membrane (GO:0098552)	4.22	5	ITGA2, P2RY12, ITGA2B, P2RX1, CD36
receptor complex (GO:0043235)	4.01	4	ITGA2, ITGB3, MYH9, ITGA2B
protein complex involved in cell adhesion (GO:0098636)	6.37	4	MYH9, ITGB3, ITGA2, ITGA2B
plasma membrane protein complex (GO:0098797)	3.55	4	ITGA2, ITGB3, MYH9, ITGA2B
external side of plasma membrane (GO:0009897)	4.46	4	P2RY12, ITGA2, ITGA2B, CD36
integrin complex (GO:0008305)	6.37	4	MYH9, ITGB3, ITGA2, ITGA2B
plasma membrane receptor complex (GO:0098802)	4.63	4	MYH9, ITGB3, ITGA2, ITGA2B
intracellular (GO:0005622)	2.37	4	ACTN1, P2RY12, ANO6, RASGRP2
cytoplasmic vesicle part (GO:0044433)	3.41	4	ITGB3, ACTN1, ITGA2B, CD36
nuclear part (GO:0044428)	1.55	4	GFI1B, PRKACG, MYH9, P2RX1
secretory granule membrane (GO:0030667)	5.5	3	ITGB3, CD36, ITGA2B
neuron projection (GO:0043005)	3.12	3	ITGA2, P2RX1, RASGRP2
organelle membrane (GO:0031090)	1.97	3	ITGB3, CD36, ITGA2B
platelet alpha granule membrane (GO:0031092)	7.24	3	ITGB3, CD36, ITGA2B
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	TBXA2R, ITGB3, CD36
cytoplasmic vesicle (GO:0031410)	2.87	3	TBXA2R, ITGB3, CD36
bounding membrane of organelle (GO:0098588)	2.39	3	ITGB3, CD36, ITGA2B
membrane region (GO:0098589)	3.95	3	P2RY12, CD36, P2RX1
cell projection membrane (GO:0031253)	4.11	3	ITGB3, CD36, RASGRP2
cytoplasmic vesicle membrane (GO:0030659)	3.67	3	ITGB3, CD36, ITGA2B
neuron part (GO:0097458)	2.64	3	ITGA2, RASGRP2, P2RX1
intracellular vesicle (GO:0097708)	2.86	3	TBXA2R, ITGB3, CD36
vesicle membrane (GO:0012506)	3.63	3	ITGB3, CD36, ITGA2B
membrane raft (GO:0045121)	4.18	3	P2RY12, CD36, P2RX1
membrane microdomain (GO:0098857)	4.17	3	P2RY12, CD36, P2RX1
whole membrane (GO:0098805)	2.85	3	ITGB3, CD36, ITGA2B
extracellular space (GO:0005615)	2.63	3	PLAU, CD36, ACTN1
actin filament bundle (GO:0032432)	5.74	2	MYH9, ACTN1
cytoskeleton (GO:0005856)	2.55	2	MYH9, ACTN1
ruffle (GO:0001726)	5.28	2	MYH9, ACTN1
non-membrane-bounded organelle (GO:0043228)	1.76	2	MYH9, ACTN1
endoplasmic reticulum (GO:0005783)	2.56	2	TBXAS1, NBEAL2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	2	MYH9, ACTN1
stress fiber (GO:0001725)	5.81	2	MYH9, ACTN1
leading edge membrane (GO:0031256)	4.9	2	ITGB3, RASGRP2
contractile actin filament bundle (GO:0097517)	5.81	2	MYH9, ACTN1
brush border (GO:0005903)	5.68	2	MYH9, ACTN1
cell-cell adherens junction (GO:0005913)	5.81	2	MYH9, ACTN1
cytoskeletal part (GO:0044430)	2.49	2	MYH9, ACTN1
cell-cell junction (GO:0005911)	3.85	2	MYH9, ACTN1
synapse (GO:0045202)	3.58	2	MYH9, RASGRP2
extracellular region (GO:0005576)	2.18	2	PLAU, ACTN1
cluster of actin-based cell projections (GO:0098862)	5.54	2	MYH9, ACTN1
ruffle membrane (GO:0032587)	5.42	2	ITGB3, RASGRP2
actomyosin (GO:0042641)	5.66	2	MYH9, ACTN1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	-	4.46	0.001	ITGB3, CD36, PLAU, P2RY12, ITGA2B, GP6, ITGA2
protein complex involved in cell adhesion (GO:0098636)	-	6.37	0.002	ITGB3, ITGA2, ITGA2B
membrane-enclosed lumen (GO:0031974)	NEW	3.05	0.006	ITGB3, ACTN1, GP1BA, GP9, PLAU, GFI1B, ITGA2B, MYH9, CD36, ITGA2
synapse (GO:0045202)	-	3.58	0.035	GFI1B, ACTN1, PLAU, ITGB3, MYH9, RASGRP2
side of membrane (GO:0098552)	-	4.22	0.001	ITGB3, CD36, PLAU, P2RY12, ITGA2B, MYH9, GP6, P2RX1, ITGA2
cell-substrate adherens junction (GO:0005924)	-	3.83	0.01	GFI1B, CD36, ACTN1, PLAU, ITGB3, ITGA2B, ITGA2
focal adhesion (GO:0005925)	-	3.83	0.009	GFI1B, CD36, ACTN1, PLAU, ITGB3, ITGA2B, ITGA2
cell junction (GO:0030054)	-	2.75	0.017	GFI1B, CD36, ACTN1, MYH9, PLAU, ITGB3, ITGA2B, TBXA2R, RASGRP2, GP6, ITGA2
cell-substrate junction (GO:0030055)	-	3.82	0.011	GFI1B, CD36, ACTN1, PLAU, ITGB3, ITGA2B, ITGA2
secretory granule membrane (GO:0030667)	-	5.5	0.008	ITGB3, PLAU, ITGA2B, CD36
platelet alpha granule membrane (GO:0031092)	-	7.24	0.0	ITGB3, CD36, ITGA2B
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.041	PRKACG, ITGB3, CD36, ACTN1, PLAU, TBXA2R, ITGA2B, GFI1B, MYH9
membrane (GO:0016020)	-	0.68	0.035	PRKACG, GFI1B, ANO6, ACTN1, GP9, PLAU, GP1BB, TBXAS1, ITGA2B, ITGA2, TBXA2R, P2RY12, MYH9, P2RX1, CD36, NBEAL2, GP6, GP1BA, ITGB3, RASGRP2
endoplasmic reticulum part (GO:0044432)	NEW	2.73	0.009	ITGB3, ACTN1, GP1BA, GP9, PLAU, GFI1B, ITGA2B, MYH9, CD36, TBXAS1, ITGA2
plasma membrane part (GO:0044459)	-	1.95	0.0	PRKACG, GFI1B, ACTN1, GP1BA, GP9, MYH9, PLAU, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RY12, RASGRP2, P2RX1, CD36, GP6, ITGA2
membrane region (GO:0098589)	-	3.95	0.021	ITGB3, GP1BA, ACTN1, PLAU, TBXAS1, ITGA2B, TBXA2R, P2RY12, MYH9, P2RX1, CD36, ITGA2
cell surface (GO:0009986)	-	3.44	0.0	P2RY12, GP1BA, ACTN1, ANO6, PLAU, ITGB3, ITGA2B, GP6, CD36, ITGA2
anchoring junction (GO:0070161)	-	3.61	0.001	GFI1B, CD36, ACTN1, PLAU, ITGB3, ITGA2B, MYH9, ITGA2
integrin complex (GO:0008305)	-	6.37	0.002	ITGB3, ITGA2, ITGA2B
adherens junction (GO:0005912)	-	3.66	0.001	GFI1B, CD36, ACTN1, PLAU, ITGB3, ITGA2B, MYH9, ITGA2
integral component of plasma membrane (GO:0005887)	-	2.57	0.0	GFI1B, GP1BA, ACTN1, GP9, PLAU, GP1BB, ITGB3, ITGA2B, TBXA2R, P2RX1, CD36, GP6
plasma membrane (GO:0005886)	-	1.39	0.0	PRKACG, ANO6, GFI1B, GP1BA, CD36, GP9, MYH9, PLAU, GP1BB, ITGB3, ITGA2B, ACTN1, TBXA2R, P2RY12, ITGA2, P2RX1, GP6, RASGRP2
receptor complex (GO:0043235)	-	4.01	0.003	ITGB3, CD36, ACTN1, PLAU, ITGA2B, MYH9, ITGA2
organelle lumen (GO:0043233)	NEW	3.05	0.003	ITGB3, ACTN1, GP1BA, GP9, PLAU, GFI1B, ITGA2B, MYH9, CD36, ITGA2
external encapsulating structure part (GO:0044462)	NEW	8.42	0.002	ITGA2, P2RX1
contractile ring (GO:0070938)	NEW	7.61	0.035	MYH9, ACTN1