| Disease ID | Disease name | Source of annotation with RASGRP2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS231200 | BLEEDING DISORDER, PLATELET-TYPE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 21 | NBEAL2, ANO6, GP1BA, ITGA2, GFI1B, ITGA2B, PLAU, PRKACG, P2RY12, ACTN1, TBXAS1, P2RX1, GP6, CD36, SLFN14, ITGB3, GP9, GP1BB, RASGRP2, TBXA2R, MYH9 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Platelet activation | hsa04611 | 5.66 |
| Pathways in cancer | hsa05200 | 3.98 |
| Rap1 signaling pathway | hsa04015 | 4.97 |
| Ras signaling pathway | hsa04014 | 4.9 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| Chemokine signaling pathway | hsa04062 | 5.19 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Effects of PIP2 hydrolysis | R-HSA-114508 | 8.34 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 7.77 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.03 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| Immune System | R-HSA-168256 | 2.37 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Integrin alphaIIb beta3 signaling | R-HSA-354192 | 8.23 |
| Rap1 signalling | R-HSA-392517 | 8.98 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| FCERI mediated NF-kB activation | R-HSA-2871837 | 5.11 |
| GO term | GO ID | GO IC |
|---|---|---|
| cation binding | GO:0043169 | 1.4 |
| metal ion binding | GO:0046872 | 1.41 |
| diacylglycerol binding | GO:0019992 | 7.34 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| lipid binding | GO:0008289 | 3.26 |
| ion binding | GO:0043167 | 1.36 |
| binding | GO:0005488 | 0.18 |
| molecular function regulator | GO:0098772 | 2.51 |
| calcium ion binding | GO:0005509 | 3.17 |