Disease table of ALCOHOL DEPENDENCE OMIM ID: 103780

Gene-disease associations table

GeneAssociated with ALCOHOL DEPENDENCE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TAS2R16OMIMHGNC link7q31.321103780
ALDH2ClinVarHGNC link12q24.122610251, 103780
HTR2AOMIMHGNC link13q14.25103780, 181500, 608516, 164230, 606788
ADH1BClinVar, OMIMHGNC link4q231103780
RCBTB1OMIMHGNC link13q14.21103780
ADH1CClinVar, OMIMHGNC link4q232PS168600, 103780
GABRA2OMIMHGNC link4p121103780

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 2252ADH1C, ADH1B
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
4q232ADH1C, ADH1B
13q14.22RCBTB1, HTR2A
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
4q232ADH1C, ADH1B
13q142RCBTB1, HTR2A
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
4q22ADH1C, ADH1B
13q12RCBTB1, HTR2A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
13q2RCBTB1, HTR2A
4q2ADH1C, ADH1B
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
132RCBTB1, HTR2A
43GABRA2, ADH1C, ADH1B
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ALDH2RCBTB1No2CUL3, APP
ADH1BADH1CYes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TAS2R16HTR2ANo-26GNG2, LPAR2, LPAR5, GPR17, AGT, BDKRB2, CASR, LPAR3, KNG1, APP, ANXA1, GNB1, MCHR2, NMUR1, BDKRB1, NMU, FPR2, GRM3, LPAR1, NMS, MTRNR2L2, NMUR2, SAA1, GRM2, PMCH, MCHR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493ADH1B, ALDH2, ADH1C
Glycolysis / Gluconeogenesishsa000106.643ADH1B, ALDH2, ADH1C
Fatty acid degradationhsa000717.153ADH1B, ALDH2, ADH1C
Metabolism of xenobiotics by cytochrome P450hsa009806.482ADH1B, ADH1C
Drug metabolism - cytochrome P450hsa009826.62ADH1B, ADH1C
Tyrosine metabolismhsa003507.642ADH1B, ADH1C
Retinol metabolismhsa008306.792ADH1B, ADH1C
Chemical carcinogenesishsa052046.362ADH1B, ADH1C
Neuroactive ligand-receptor interactionhsa040804.582GABRA2, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
Tyrosine metabolism (hsa00350) -7.640.017ADH1B, ADH1C
Glycolysis / Gluconeogenesis (hsa00010) -6.640.002ADH1B, ALDH2, ADH1C
Fatty acid degradation (hsa00071) -7.150.001ADH1B, ALDH2, ADH1C
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Biological oxidationsR-HSA-2118595.553ADH1B, ALDH2, ADH1C
Phase 1 - Functionalization of compoundsR-HSA-2119456.73ADH1B, ALDH2, ADH1C
MetabolismR-HSA-14307282.343ADH1B, ALDH2, ADH1C
Signal TransductionR-HSA-1625821.783TAS2R16, ADH1C, HTR2A
Ethanol oxidationR-HSA-713849.663ADH1B, ALDH2, ADH1C
Neuronal SystemR-HSA-1123164.822GABRA2, ALDH2
GPCR downstream signalingR-HSA-3883963.072TAS2R16, HTR2A
Transmission across Chemical SynapsesR-HSA-1123155.282GABRA2, ALDH2
GPCR ligand bindingR-HSA-5007924.192TAS2R16, HTR2A
Signaling by GPCRR-HSA-3727902.682TAS2R16, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
Ethanol oxidation (R-HSA-71384) -9.660.0ADH1B, ALDH2, ADH1C
Biological oxidations (R-HSA-211859) -5.550.005ADH1B, ALDH2, ADH1C
Phase 1 - Functionalization of compounds (R-HSA-211945) -6.70.002ADH1B, ALDH2, ADH1C
Transmission across Chemical Synapses (R-HSA-112315) -5.280.044GABRA2, ALDH2, HTR2A
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184ADH1B, TAS2R16, ADH1C, HTR2A
signaling receptor activity (GO:0038023) 2.493TAS2R16, GABRA2, HTR2A
catalytic activity (GO:0003824) 1.053ADH1B, ALDH2, ADH1C
molecular transducer activity (GO:0060089) 2.323TAS2R16, GABRA2, HTR2A
transmembrane signaling receptor activity (GO:0004888) 2.573TAS2R16, GABRA2, HTR2A
receptor activity (GO:0004872) 2.323TAS2R16, GABRA2, HTR2A
signal transducer activity (GO:0004871) 2.283TAS2R16, GABRA2, HTR2A
transmembrane receptor activity (GO:0099600) 2.533TAS2R16, GABRA2, HTR2A
oxidoreductase activity (GO:0016491) 3.123ADH1B, ALDH2, ADH1C
cation binding (GO:0043169) 1.42ADH1B, ADH1C
G-protein coupled receptor activity (GO:0004930) 2.952TAS2R16, HTR2A
oxidoreductase activity, acting on CH-OH group of donors (GO:0016614) 4.832ADH1B, ADH1C
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) 5.02ADH1B, ADH1C
transition metal ion binding (GO:0046914) 2.482ADH1B, ADH1C
(GO:0004024) 7.952ADH1B, ADH1C
(GO:0004022) 7.662ADH1B, ADH1C
ion binding (GO:0043167) 1.362ADH1B, ADH1C
zinc ion binding (GO:0008270) 2.662ADH1B, ADH1C
protein binding (GO:0005515) 0.462TAS2R16, HTR2A
metal ion binding (GO:0046872) 1.412ADH1B, ADH1C

NET-GE enrichment

Term New enriched termICP valueGenes
alcohol dehydrogenase (NAD) activity (GO:0004022) -7.660.001ADH1B, ADH1C
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) -5.00.042ADH1B, ADH1C
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.486ADH1C, HTR2A, RCBTB1, GABRA2, ADH1B, ALDH2
organic substance metabolic process (GO:0071704) 0.634ADH1B, RCBTB1, ADH1C, ALDH2
biological regulation (GO:0065007) 0.394TAS2R16, GABRA2, RCBTB1, HTR2A
regulation of biological process (GO:0050789) 0.454TAS2R16, GABRA2, RCBTB1, HTR2A
metabolic process (GO:0008152) 0.584ADH1B, RCBTB1, ADH1C, ALDH2
regulation of cellular process (GO:0050794) 0.54TAS2R16, GABRA2, RCBTB1, HTR2A
single-organism metabolic process (GO:0044710) 1.633ADH1B, ALDH2, ADH1C
cellular process (GO:0009987) 0.263RCBTB1, GABRA2, HTR2A
organic hydroxy compound metabolic process (GO:1901615) 3.843ADH1B, ALDH2, ADH1C
alcohol metabolic process (GO:0006066) 4.23ADH1B, ALDH2, ADH1C
(GO:0006067) 7.093ADH1B, ALDH2, ADH1C
single-organism cellular process (GO:0044763) 0.653RCBTB1, GABRA2, HTR2A
small molecule metabolic process (GO:0044281) 2.383ADH1B, ALDH2, ADH1C
primary alcohol metabolic process (GO:0034308) 5.93ADH1B, ALDH2, ADH1C
(GO:0006069) 7.243ADH1B, ALDH2, ADH1C
G-protein coupled receptor signaling pathway (GO:0007186) 2.643TAS2R16, GABRA2, HTR2A
oxidation-reduction process (GO:0055114) 2.913ADH1B, ALDH2, ADH1C
signal transduction (GO:0007165) 1.283TAS2R16, GABRA2, HTR2A
regulation of primary metabolic process (GO:0080090) 1.082RCBTB1, HTR2A
regulation of metabolic process (GO:0019222) 1.022RCBTB1, HTR2A
regulation of cellular biosynthetic process (GO:0031326) 1.382RCBTB1, HTR2A
regulation of cellular metabolic process (GO:0031323) 1.072RCBTB1, HTR2A
detection of stimulus involved in sensory perception (GO:0050906) 3.462TAS2R16, HTR2A
transmembrane transport (GO:0055085) 2.722GABRA2, HTR2A
regulation of macromolecule metabolic process (GO:0060255) 1.082RCBTB1, HTR2A
inorganic ion transmembrane transport (GO:0098660) 3.382GABRA2, HTR2A
regulation of biological quality (GO:0065008) 1.682GABRA2, HTR2A
multicellular organismal process (GO:0032501) 1.452TAS2R16, HTR2A
primary metabolic process (GO:0044238) 0.692RCBTB1, ALDH2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432RCBTB1, HTR2A
neurological system process (GO:0050877) 2.642TAS2R16, HTR2A
ion transport (GO:0006811) 2.662GABRA2, HTR2A
transport (GO:0006810) 1.512GABRA2, HTR2A
regulation of biosynthetic process (GO:0009889) 1.372RCBTB1, HTR2A
sensory perception (GO:0007600) 2.932TAS2R16, HTR2A
ion transmembrane transport (GO:0034220) 3.082GABRA2, HTR2A
single-organism transport (GO:0044765) 2.182GABRA2, HTR2A
regulation of nitrogen compound metabolic process (GO:0051171) 1.362RCBTB1, HTR2A
chemical synaptic transmission (GO:0007268) 3.982GABRA2, HTR2A
cell-cell signaling (GO:0007267) 3.352GABRA2, HTR2A
cell communication (GO:0007154) 3.042GABRA2, HTR2A
establishment of localization (GO:0051234) 1.482GABRA2, HTR2A
localization (GO:0051179) 1.42GABRA2, HTR2A
single-organism localization (GO:1902578) 2.092GABRA2, HTR2A
system process (GO:0003008) 2.32TAS2R16, HTR2A
single organism signaling (GO:0044700) 3.252GABRA2, HTR2A
detection of stimulus (GO:0051606) 3.222TAS2R16, HTR2A
response to stimulus (GO:0050896) 1.222TAS2R16, HTR2A
anterograde trans-synaptic signaling (GO:0098916) 3.982GABRA2, HTR2A
signaling (GO:0023052) 3.252GABRA2, HTR2A
synaptic signaling (GO:0099536) 3.982GABRA2, HTR2A
trans-synaptic signaling (GO:0099537) 3.982GABRA2, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
xenobiotic metabolic process (GO:0006805) NEW5.190.006ADH1B, ALDH2, ADH1C
primary alcohol metabolic process (GO:0034308) -5.90.003ADH1B, ALDH2, ADH1C
ethanol metabolic process (GO:0006067) -7.090.0ADH1B, ALDH2, ADH1C
ethanol oxidation (GO:0006069) -7.240.0ADH1B, ALDH2, ADH1C
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.287TAS2R16, GABRA2, ADH1C, RCBTB1, HTR2A, ADH1B, ALDH2
cell part (GO:0044464) 0.117TAS2R16, GABRA2, ADH1C, RCBTB1, HTR2A, ADH1B, ALDH2
cytoplasmic part (GO:0044444) 0.826TAS2R16, HTR2A, ADH1C, GABRA2, ADH1B, ALDH2
cytoplasm (GO:0005737) 1.014ADH1B, RCBTB1, HTR2A, ADH1C
intracellular organelle (GO:0043229) 0.514RCBTB1, TAS2R16, ALDH2, HTR2A
membrane-bounded organelle (GO:0043227) 0.474RCBTB1, TAS2R16, ALDH2, HTR2A
organelle (GO:0043226) 0.44RCBTB1, TAS2R16, ALDH2, HTR2A
intracellular membrane-bounded organelle (GO:0043231) 0.64RCBTB1, TAS2R16, ALDH2, HTR2A
integral component of membrane (GO:0016021) 1.143TAS2R16, GABRA2, HTR2A
membrane (GO:0016020) 0.683TAS2R16, GABRA2, HTR2A
intracellular organelle part (GO:0044446) 0.813TAS2R16, GABRA2, ALDH2
organelle part (GO:0044422) 0.793TAS2R16, GABRA2, ALDH2
plasma membrane (GO:0005886) 1.393TAS2R16, GABRA2, HTR2A
membrane part (GO:0044425) 0.953TAS2R16, GABRA2, HTR2A
plasma membrane part (GO:0044459) 1.953TAS2R16, GABRA2, HTR2A
cytosol (GO:0005829) 1.683ADH1B, ADH1C, HTR2A
intrinsic component of membrane (GO:0031224) 1.133TAS2R16, GABRA2, HTR2A
plasma membrane region (GO:0098590) 2.972GABRA2, HTR2A
cell projection (GO:0042995) 2.472GABRA2, HTR2A
vesicle (GO:0031982) 1.642ALDH2, HTR2A
membrane-bounded vesicle (GO:0031988) 1.712ALDH2, HTR2A
neuron part (GO:0097458) 2.642GABRA2, HTR2A
neuron projection (GO:0043005) 3.122GABRA2, HTR2A
axon (GO:0030424) 4.152GABRA2, HTR2A