Disease table of CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL OMIM ID: 209880

Gene-disease associations table

GeneAssociated with CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ASCL1ClinVar, OMIMHGNC link12q23.21209880
RETClinVar, OMIM, HUMSAVARHGNC link10q11.216171300, 155240, PS142623, 209880, 191830, PS131100
GDNFClinVar, OMIMHGNC link5p13.23171300, PS142623, 209880
BDNFClinVar, OMIM, HUMSAVARHGNC link11p14.14607499, 164230, 209880, 610269
PHOX2BClinVar, OMIM, HUMSAVARHGNC link4p132613013, 209880
EDN3OMIMHGNC link20q13.323PS193500, PS142623, 209880

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ASCL1YES7TPH1, CHRNA3, PCSK6, CHRNA5, CHRNB4, IGF2, DKK10
PHOX2BYES5DBH, ALK, TLX2, PHOX2A, MSX10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ASCL1YES4HES1, NHLH2, HES6, LMO30
RETYES5TFAP2C, SOX9, ESR1, SOX10, FOXA10
GDNFYES2NFKB1, EGR10
BDNFYES2REST, CREB10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RETGDNFNo1GFRA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ASCL1RETNo-1PROM1
ASCL1BDNFNo-3SHH, SIRT1, MMP7
ASCL1PHOX2BNo-2NEUROG2, TCF3
ASCL1EDN3No-1PROK2
RETGDNFYesactivation, binding38PTPN11, RASA1, SHANK3, GRB7, PXN, CTNND1, CREB1, NRTN, RAP1A, PRKACA, CTNNA1, MAPK8, CRK, GFRA2, PIK3CA, CTNNB1, SOS1, SHC1, PRKCA, HRAS, CDH1, GRB2, DOK1, SRC, GAB1, NCK1, PSPN, PDLIM7, PAX2, IRS1, GRB10, PIK3R1, BCAR1, DOK6, GFRA1, FRS2, DOK4, DOK5
RETBDNFNo-14PLCG1, RAP1A, MAPK8, PIK3R1, PIK3CA, SHC1, CTNND1, CREB1, SOS1, CTNNB1, TRAF6, FRS2, GRB2, CTNNA1
GDNFBDNFNo-17MAPK8, CTNNA1, CTNNB1, TGFB2, JUN, SOS1, SHC1, ADORA2A, PIK3R1, CREB1, PIK3CA, RAP1A, SST, FRS2, FOS, GRB2, CTNND1
GDNFEDN3No-2FOS, EDN1
BDNFEDN3No-3FOS, HIF1A, EGR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
RETGDNFYes2RET, GDNF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
protein binding (GO:0005515) 0.465EDN3, GDNF, ASCL1, RET, BDNF
organic cyclic compound binding (GO:0097159) 1.053RET, ASCL1, PHOX2B
receptor binding (GO:0005102) 2.433EDN3, GDNF, BDNF
heterocyclic compound binding (GO:1901363) 1.063PHOX2B, ASCL1, RET
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312RET, GDNF
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022RET, GDNF
core promoter proximal region DNA binding (GO:0001159) 3.822PHOX2B, ASCL1
nucleic acid binding transcription factor activity (GO:0001071) 2.652PHOX2B, ASCL1
nucleic acid binding (GO:0003676) 1.442PHOX2B, ASCL1
DNA binding (GO:0003677) 1.922PHOX2B, ASCL1
molecular function regulator (GO:0098772) 2.512RET, GDNF
sequence-specific DNA binding (GO:0043565) 2.792PHOX2B, ASCL1
sequence-specific double-stranded DNA binding (GO:1990837) 3.22PHOX2B, ASCL1
growth factor activity (GO:0008083) 4.662GDNF, BDNF
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832PHOX2B, ASCL1
double-stranded DNA binding (GO:0003690) 3.092PHOX2B, ASCL1
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942PHOX2B, ASCL1
identical protein binding (GO:0042802) 2.632ASCL1, GDNF
protein homodimerization activity (GO:0042803) 3.162ASCL1, GDNF
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362PHOX2B, ASCL1
regulatory region nucleic acid binding (GO:0001067) 3.032PHOX2B, ASCL1
protein dimerization activity (GO:0046983) 2.722ASCL1, GDNF
transcription regulatory region DNA binding (GO:0044212) 3.032PHOX2B, ASCL1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652PHOX2B, ASCL1
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242PHOX2B, ASCL1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372PHOX2B, ASCL1
regulatory region DNA binding (GO:0000975) 3.032PHOX2B, ASCL1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882PHOX2B, ASCL1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292PHOX2B, ASCL1

NET-GE enrichment

Term New enriched termICP valueGenes
transcription regulatory region DNA binding (GO:0044212) -3.030.002PHOX2B, ASCL1, GDNF, BDNF, RET
sequence-specific DNA binding (GO:0043565) -2.790.013PHOX2B, ASCL1, GDNF, BDNF, RET
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.011PHOX2B, GDNF, BDNF, RET
regulatory region nucleic acid binding (GO:0001067) -3.030.002PHOX2B, ASCL1, GDNF, BDNF, RET
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) NEW5.230.009RET, GDNF, BDNF
core promoter proximal region DNA binding (GO:0001159) -3.820.002PHOX2B, GDNF, BDNF, RET
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.018PHOX2B, GDNF, BDNF, RET
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.011PHOX2B, GDNF, BDNF, RET
regulatory region DNA binding (GO:0000975) -3.030.002RET, PHOX2B, ASCL1, GDNF, BDNF
core promoter proximal region sequence-specific DNA binding (GO:0000987) -3.830.002PHOX2B, GDNF, BDNF, RET
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) -3.880.001PHOX2B, GDNF, BDNF, RET
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.035RET, ASCL1, GDNF, BDNF
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.366RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of cell differentiation (GO:0045597) 3.016RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
cellular process (GO:0009987) 0.266RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of multicellular organismal process (GO:0051240) 2.496RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
anatomical structure development (GO:0048856) 1.586RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of cellular process (GO:0050794) 0.56RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
single-organism developmental process (GO:0044767) 1.496RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of cell differentiation (GO:0045595) 2.426RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
single-organism cellular process (GO:0044763) 0.656RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of multicellular organismal process (GO:0051239) 1.876RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of biological process (GO:0048518) 1.26RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
biological regulation (GO:0065007) 0.396RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
movement of cell or subcellular component (GO:0006928) 2.616RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of biological process (GO:0050789) 0.456RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
single-organism process (GO:0044699) 0.486RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of cellular process (GO:0048522) 1.36RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of metabolic process (GO:0009893) 1.745PHOX2B, EDN3, ASCL1, RET, GDNF
regulation of metabolic process (GO:0019222) 1.025EDN3, ASCL1, PHOX2B, GDNF, RET
positive regulation of cellular metabolic process (GO:0031325) 1.815EDN3, ASCL1, PHOX2B, GDNF, RET
regulation of response to stimulus (GO:0048583) 1.545RET, EDN3, ASCL1, GDNF, BDNF
signal transduction (GO:0007165) 1.285RET, EDN3, ASCL1, GDNF, BDNF
regulation of signaling (GO:0023051) 1.725EDN3, ASCL1, GDNF, BDNF, RET
regulation of cell communication (GO:0010646) 1.735EDN3, GDNF, ASCL1, RET, BDNF
regulation of primary metabolic process (GO:0080090) 1.085EDN3, ASCL1, PHOX2B, GDNF, RET
positive regulation of macromolecule metabolic process (GO:0010604) 1.815EDN3, ASCL1, PHOX2B, GDNF, RET
regulation of signal transduction (GO:0009966) 1.845EDN3, GDNF, ASCL1, RET, BDNF
cellular developmental process (GO:0048869) 1.825EDN3, PHOX2B, ASCL1, RET, GDNF
regulation of cell development (GO:0060284) 3.015PHOX2B, ASCL1, GDNF, BDNF, RET
regulation of macromolecule metabolic process (GO:0060255) 1.085PHOX2B, EDN3, ASCL1, RET, GDNF
positive regulation of cell development (GO:0010720) 3.575PHOX2B, ASCL1, GDNF, BDNF, RET
cell migration (GO:0016477) 3.125PHOX2B, EDN3, ASCL1, RET, GDNF
regulation of gene expression (GO:0010468) 1.375PHOX2B, EDN3, ASCL1, RET, GDNF
multicellular organismal process (GO:0032501) 1.455EDN3, PHOX2B, ASCL1, RET, GDNF
regulation of developmental process (GO:0050793) 2.15RET, PHOX2B, ASCL1, GDNF, BDNF
regulation of cellular metabolic process (GO:0031323) 1.075EDN3, PHOX2B, ASCL1, RET, GDNF
locomotion (GO:0040011) 2.915EDN3, ASCL1, PHOX2B, GDNF, RET
single-multicellular organism process (GO:0044707) 1.785EDN3, ASCL1, PHOX2B, GDNF, RET
cell motility (GO:0048870) 3.025PHOX2B, EDN3, ASCL1, RET, GDNF
positive regulation of developmental process (GO:0051094) 2.775PHOX2B, GDNF, ASCL1, RET, BDNF
regulation of multicellular organismal development (GO:2000026) 2.315PHOX2B, ASCL1, GDNF, BDNF, RET
system development (GO:0048731) 2.925RET, PHOX2B, ASCL1, GDNF, BDNF
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564PHOX2B, ASCL1, RET, GDNF
regulation of RNA metabolic process (GO:0051252) 1.524RET, ASCL1, PHOX2B, GDNF
positive regulation of biosynthetic process (GO:0009891) 2.294PHOX2B, ASCL1, RET, GDNF
regulation of cellular biosynthetic process (GO:0031326) 1.384RET, ASCL1, PHOX2B, GDNF
positive regulation of response to stimulus (GO:0048584) 2.184EDN3, ASCL1, RET, BDNF
regulation of cellular component organization (GO:0051128) 2.014EDN3, GDNF, RET, BDNF
positive regulation of signaling (GO:0023056) 2.414EDN3, ASCL1, RET, BDNF
positive regulation of gene expression (GO:0010628) 2.354PHOX2B, ASCL1, RET, GDNF
cell surface receptor signaling pathway (GO:0007166) 2.094EDN3, ASCL1, RET, BDNF
ameboidal-type cell migration (GO:0001667) 4.714EDN3, PHOX2B, GDNF, RET
regulation of cell death (GO:0010941) 2.434RET, ASCL1, GDNF, BDNF
regulation of apoptotic process (GO:0042981) 2.54RET, ASCL1, GDNF, BDNF
positive regulation of cell communication (GO:0010647) 2.414EDN3, ASCL1, RET, BDNF
cellular component organization or biogenesis (GO:0071840) 1.224PHOX2B, GDNF, BDNF, RET
regulation of neurogenesis (GO:0050767) 3.214PHOX2B, ASCL1, RET, BDNF
cellular macromolecule metabolic process (GO:0044260) 0.934PHOX2B, ASCL1, RET, GDNF
organic substance metabolic process (GO:0071704) 0.634PHOX2B, ASCL1, RET, GDNF
positive regulation of signal transduction (GO:0009967) 2.54EDN3, ASCL1, RET, BDNF
positive regulation of cellular biosynthetic process (GO:0031328) 2.34PHOX2B, ASCL1, RET, GDNF
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464PHOX2B, ASCL1, RET, GDNF
cellular component organization (GO:0016043) 1.244PHOX2B, GDNF, BDNF, RET
positive regulation of neurogenesis (GO:0050769) 3.774PHOX2B, ASCL1, RET, BDNF
regulation of neuron differentiation (GO:0045664) 3.394RET, ASCL1, PHOX2B, BDNF
regulation of programmed cell death (GO:0043067) 2.494RET, ASCL1, GDNF, BDNF
positive regulation of neuron differentiation (GO:0045666) 3.984PHOX2B, ASCL1, RET, BDNF
negative regulation of biological process (GO:0048519) 1.334PHOX2B, ASCL1, GDNF, BDNF
regulation of cell proliferation (GO:0042127) 2.414EDN3, ASCL1, PHOX2B, GDNF
cell differentiation (GO:0030154) 2.144PHOX2B, ASCL1, EDN3, RET
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354PHOX2B, ASCL1, RET, GDNF
neuron differentiation (GO:0030182) 4.174EDN3, PHOX2B, ASCL1, RET
regulation of macromolecule biosynthetic process (GO:0010556) 1.434RET, ASCL1, PHOX2B, GDNF
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434RET, ASCL1, PHOX2B, GDNF
animal organ development (GO:0048513) 2.534PHOX2B, ASCL1, RET, GDNF
regulation of biosynthetic process (GO:0009889) 1.374RET, ASCL1, PHOX2B, GDNF
tissue development (GO:0009888) 3.274PHOX2B, ASCL1, RET, GDNF
regulation of nucleic acid-templated transcription (GO:1903506) 1.554RET, ASCL1, PHOX2B, GDNF
positive regulation of transcription, DNA-templated (GO:0045893) 2.564PHOX2B, ASCL1, RET, GDNF
metabolic process (GO:0008152) 0.584PHOX2B, ASCL1, RET, GDNF
regulation of RNA biosynthetic process (GO:2001141) 1.554PHOX2B, ASCL1, RET, GDNF
neural crest cell migration (GO:0001755) 5.764EDN3, PHOX2B, GDNF, RET
primary metabolic process (GO:0044238) 0.694RET, ASCL1, PHOX2B, GDNF
nervous system development (GO:0007399) 3.534RET, ASCL1, GDNF, BDNF
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294PHOX2B, ASCL1, RET, GDNF
regulation of transcription, DNA-templated (GO:0006355) 1.564PHOX2B, ASCL1, RET, GDNF
positive regulation of RNA metabolic process (GO:0051254) 2.514RET, ASCL1, PHOX2B, GDNF
cellular metabolic process (GO:0044237) 0.694RET, ASCL1, PHOX2B, GDNF
macromolecule metabolic process (GO:0043170) 0.834RET, ASCL1, PHOX2B, GDNF
positive regulation of RNA biosynthetic process (GO:1902680) 2.544PHOX2B, ASCL1, RET, GDNF
positive regulation of nervous system development (GO:0051962) 3.644RET, ASCL1, PHOX2B, BDNF
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394RET, ASCL1, PHOX2B, GDNF
regulation of nervous system development (GO:0051960) 3.14RET, ASCL1, PHOX2B, BDNF
positive regulation of cellular component organization (GO:0051130) 2.684EDN3, GDNF, RET, BDNF
negative regulation of cellular process (GO:0048523) 1.414PHOX2B, ASCL1, GDNF, BDNF
regulation of nitrogen compound metabolic process (GO:0051171) 1.364PHOX2B, ASCL1, RET, GDNF
regulation of cell morphogenesis (GO:0022604) 3.43RET, GDNF, BDNF
regulation of anatomical structure morphogenesis (GO:0022603) 2.793RET, GDNF, BDNF
enteric nervous system development (GO:0048484) 7.333PHOX2B, RET, GDNF
regulation of neuron apoptotic process (GO:0043523) 4.473ASCL1, GDNF, BDNF
intracellular signal transduction (GO:0035556) 2.393EDN3, RET, GDNF
anatomical structure morphogenesis (GO:0009653) 2.533PHOX2B, RET, GDNF
multicellular organism development (GO:0007275) 2.543PHOX2B, ASCL1, EDN3
positive regulation of catalytic activity (GO:0043085) 2.43EDN3, RET, GDNF
cellular response to stimulus (GO:0051716) 1.973RET, ASCL1, PHOX2B
positive regulation of cell cycle (GO:0045787) 3.943EDN3, ASCL1, PHOX2B
negative regulation of apoptotic process (GO:0043066) 3.043ASCL1, GDNF, BDNF
sympathetic nervous system development (GO:0048485) 6.963PHOX2B, ASCL1, GDNF
positive regulation of molecular function (GO:0044093) 2.233EDN3, RET, GDNF
regulation of molecular function (GO:0065009) 1.783EDN3, RET, GDNF
regulation of biological quality (GO:0065008) 1.683EDN3, RET, GDNF
negative regulation of programmed cell death (GO:0043069) 3.023ASCL1, GDNF, BDNF
positive regulation of cell proliferation (GO:0008284) 3.013EDN3, ASCL1, GDNF
negative regulation of cell death (GO:0060548) 2.953ASCL1, GDNF, BDNF
regulation of catalytic activity (GO:0050790) 1.973EDN3, RET, GDNF
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.913RET, GDNF, BDNF
regulation of mitotic cell cycle (GO:0007346) 3.713EDN3, ASCL1, PHOX2B
response to chemical (GO:0042221) 1.983PHOX2B, ASCL1, RET
regulation of neuron death (GO:1901214) 4.193ASCL1, GDNF, BDNF
regulation of localization (GO:0032879) 1.943EDN3, RET, GDNF
response to organic substance (GO:0010033) 2.23RET, ASCL1, PHOX2B
system process (GO:0003008) 2.33EDN3, PHOX2B, GDNF
regulation of cell cycle (GO:0051726) 2.933PHOX2B, ASCL1, EDN3
response to stimulus (GO:0050896) 1.223PHOX2B, ASCL1, RET
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243PHOX2B, ASCL1, GDNF
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813PHOX2B, ASCL1, GDNF
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692RET, GDNF
regulation of phosphate metabolic process (GO:0019220) 2.352EDN3, RET
regulation of secretion (GO:0051046) 3.22EDN3, GDNF
regulation of apoptotic signaling pathway (GO:2001233) 3.832RET, GDNF
regulation of transport (GO:0051049) 2.242EDN3, GDNF
cell development (GO:0048468) 3.282PHOX2B, ASCL1
cell maturation (GO:0048469) 4.982RET, ASCL1
muscle system process (GO:0003012) 4.182EDN3, GDNF
negative regulation of neuron apoptotic process (GO:0043524) 4.822GDNF, BDNF
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242RET, BDNF
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542RET, BDNF
organic cyclic compound biosynthetic process (GO:1901362) 1.662PHOX2B, ASCL1
regulation of cell projection organization (GO:0031344) 3.382RET, BDNF
organic cyclic compound metabolic process (GO:1901360) 1.262PHOX2B, ASCL1
positive regulation of cell projection organization (GO:0031346) 3.992RET, BDNF
single-organism metabolic process (GO:0044710) 1.632RET, GDNF
positive regulation of secretion (GO:0051047) 3.852EDN3, GDNF
MAPK cascade (GO:0000165) 3.912RET, GDNF
response to growth factor (GO:0070848) 4.142PHOX2B, ASCL1
negative regulation of neuron differentiation (GO:0045665) 4.452PHOX2B, ASCL1
regulation of epithelial cell differentiation (GO:0030856) 4.962ASCL1, GDNF
negative regulation of cell development (GO:0010721) 4.022PHOX2B, ASCL1
muscle contraction (GO:0006936) 4.372EDN3, GDNF
positive regulation of transport (GO:0051050) 2.92EDN3, GDNF
phasic smooth muscle contraction (GO:0014821) 6.962EDN3, GDNF
smooth muscle contraction (GO:0006939) 5.92EDN3, GDNF
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) 5.862RET, GDNF
positive regulation of neuron projection development (GO:0010976) 4.262RET, BDNF
regulation of neuron projection development (GO:0010975) 3.692RET, BDNF
noradrenergic neuron development (GO:0003358) 8.632PHOX2B, ASCL1
tube formation (GO:0035148) 4.982RET, GDNF
heterocycle metabolic process (GO:0046483) 1.312PHOX2B, ASCL1
regulation of phosphorylation (GO:0042325) 2.52EDN3, RET
single organism signaling (GO:0044700) 3.252EDN3, BDNF
positive regulation of phosphorylation (GO:0042327) 2.92EDN3, RET
protein metabolic process (GO:0019538) 1.452RET, GDNF
immune system process (GO:0002376) 2.292EDN3, RET
aromatic compound biosynthetic process (GO:0019438) 1.72PHOX2B, ASCL1
neuron development (GO:0048666) 4.82PHOX2B, ASCL1
cellular response to chemical stimulus (GO:0070887) 2.572PHOX2B, RET
positive regulation of kidney development (GO:0090184) 6.022RET, GDNF
response to retinoic acid (GO:0032526) 5.022RET, ASCL1
nitrogen compound metabolic process (GO:0006807) 1.132PHOX2B, ASCL1
neuron migration (GO:0001764) 5.02PHOX2B, ASCL1
autonomic nervous system development (GO:0048483) 8.122PHOX2B, GDNF
developmental maturation (GO:0021700) 4.72RET, ASCL1
nucleic acid-templated transcription (GO:0097659) 1.912PHOX2B, ASCL1
cellular protein metabolic process (GO:0044267) 1.632RET, GDNF
positive regulation of GTPase activity (GO:0043547) 3.282RET, GDNF
positive regulation of hydrolase activity (GO:0051345) 2.912RET, GDNF
regulation of anatomical structure size (GO:0090066) 3.782EDN3, RET
signal transduction by protein phosphorylation (GO:0023014) 3.792RET, GDNF
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012RET, GDNF
heterocycle biosynthetic process (GO:0018130) 1.72PHOX2B, ASCL1
positive regulation of cell migration (GO:0030335) 3.772EDN3, RET
phosphorylation (GO:0016310) 2.632RET, GDNF
macromolecule modification (GO:0043412) 1.732RET, GDNF
protein modification process (GO:0036211) 1.792RET, GDNF
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722PHOX2B, ASCL1
negative regulation of neuron death (GO:1901215) 4.572GDNF, BDNF
regulation of hydrolase activity (GO:0051336) 2.532RET, GDNF
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592PHOX2B, ASCL1
positive regulation of protein modification process (GO:0031401) 2.72EDN3, RET
negative regulation of nervous system development (GO:0051961) 4.152PHOX2B, ASCL1
regulation of cell motility (GO:2000145) 3.162EDN3, RET
transcription, DNA-templated (GO:0006351) 1.912PHOX2B, ASCL1
positive regulation of cell motility (GO:2000147) 3.742EDN3, RET
RNA biosynthetic process (GO:0032774) 1.842PHOX2B, ASCL1
regulation of cell cycle process (GO:0010564) 3.52EDN3, PHOX2B
kidney development (GO:0001822) 4.792RET, GDNF
cellular biosynthetic process (GO:0044249) 1.372PHOX2B, ASCL1
cellular nitrogen compound metabolic process (GO:0034641) 1.222PHOX2B, ASCL1
signaling (GO:0023052) 3.252EDN3, BDNF
regulation of secretion by cell (GO:1903530) 3.282EDN3, GDNF
glial cell differentiation (GO:0010001) 5.482PHOX2B, ASCL1
positive regulation of secretion by cell (GO:1903532) 3.932EDN3, GDNF
regulation of GTPase activity (GO:0043087) 3.212RET, GDNF
response to endogenous stimulus (GO:0009719) 2.792PHOX2B, ASCL1
nucleobase-containing compound metabolic process (GO:0006139) 1.352PHOX2B, ASCL1
regulation of intracellular signal transduction (GO:1902531) 2.312EDN3, RET
regulation of system process (GO:0044057) 3.532EDN3, PHOX2B
positive regulation of phosphorus metabolic process (GO:0010562) 2.782EDN3, RET
negative regulation of multicellular organismal process (GO:0051241) 2.842PHOX2B, ASCL1
regulation of protein metabolic process (GO:0051246) 1.932EDN3, RET
positive regulation of protein metabolic process (GO:0051247) 2.432EDN3, RET
negative regulation of neurogenesis (GO:0050768) 4.222PHOX2B, ASCL1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492EDN3, RET
regulation of protein modification process (GO:0031399) 2.322EDN3, RET
central nervous system neuron differentiation (GO:0021953) 5.172PHOX2B, ASCL1
RNA metabolic process (GO:0016070) 1.592PHOX2B, ASCL1
epithelium development (GO:0060429) 4.572RET, GDNF
cellular aromatic compound metabolic process (GO:0006725) 1.32PHOX2B, ASCL1
regulation of kidney development (GO:0090183) 5.722RET, GDNF
negative regulation of cell differentiation (GO:0045596) 3.332PHOX2B, ASCL1
cellular macromolecule biosynthetic process (GO:0034645) 1.662PHOX2B, ASCL1
regulation of locomotion (GO:0040012) 3.122EDN3, RET
mesonephric tubule development (GO:0072164) 5.822RET, GDNF
embryonic epithelial tube formation (GO:0001838) 6.42RET, GDNF
metanephros development (GO:0001656) 6.022RET, GDNF
ureteric bud development (GO:0001657) 5.972RET, GDNF
negative regulation of developmental process (GO:0051093) 3.172PHOX2B, ASCL1
regulation of cellular protein metabolic process (GO:0032268) 1.992EDN3, RET
regulation of axonogenesis (GO:0050770) 4.592RET, BDNF
positive regulation of metanephros development (GO:0072216) 7.092RET, GDNF
epithelial tube formation (GO:0072175) 6.362RET, GDNF
regulation of metanephros development (GO:0072215) 6.592RET, GDNF
organic substance biosynthetic process (GO:1901576) 1.342PHOX2B, ASCL1
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652GDNF, BDNF
cell projection organization (GO:0030030) 3.142PHOX2B, GDNF
nucleic acid metabolic process (GO:0090304) 1.462PHOX2B, ASCL1
leukocyte migration (GO:0050900) 4.192EDN3, RET
positive regulation of cell death (GO:0010942) 3.322RET, ASCL1
kidney epithelium development (GO:0072073) 5.542RET, GDNF
ganglion development (GO:0061548) 7.162PHOX2B, ASCL1
response to lipid (GO:0033993) 3.112RET, ASCL1
sympathetic ganglion development (GO:0061549) 7.532PHOX2B, ASCL1
cellular component morphogenesis (GO:0032989) 3.52PHOX2B, GDNF
positive regulation of apoptotic process (GO:0043065) 3.382RET, ASCL1
cellular response to organic substance (GO:0071310) 2.782PHOX2B, RET
tissue morphogenesis (GO:0048729) 3.872RET, GDNF
positive regulation of programmed cell death (GO:0043068) 3.382RET, ASCL1
positive regulation of mitotic cell cycle (GO:0045931) 4.982EDN3, PHOX2B
protein phosphorylation (GO:0006468) 2.892RET, GDNF
regulation of cell migration (GO:0030334) 3.232EDN3, RET
positive regulation of phosphate metabolic process (GO:0045937) 2.782EDN3, RET
positive regulation of cell cycle process (GO:0090068) 4.252EDN3, PHOX2B
cellular protein modification process (GO:0006464) 1.792RET, GDNF
regulation of phosphorus metabolic process (GO:0051174) 2.352EDN3, RET
biosynthetic process (GO:0009058) 1.322PHOX2B, ASCL1
macromolecule biosynthetic process (GO:0009059) 1.612PHOX2B, ASCL1
cell-cell signaling (GO:0007267) 3.352EDN3, BDNF
cell communication (GO:0007154) 3.042EDN3, BDNF
tube development (GO:0035295) 4.412RET, GDNF
response to oxygen-containing compound (GO:1901700) 2.572RET, ASCL1
positive regulation of cellular component movement (GO:0051272) 3.712EDN3, RET
regulation of cellular component movement (GO:0051270) 3.082EDN3, RET
positive regulation of locomotion (GO:0040017) 3.712EDN3, RET
phosphate-containing compound metabolic process (GO:0006796) 2.162RET, GDNF
mesonephric epithelium development (GO:0072163) 5.82RET, GDNF
phosphorus metabolic process (GO:0006793) 2.152RET, GDNF
regulation of protein phosphorylation (GO:0001932) 2.572EDN3, RET
positive regulation of protein phosphorylation (GO:0001934) 2.952EDN3, RET
response to acid chemical (GO:0001101) 4.052RET, ASCL1

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of response to external stimulus (GO:0032103) NEW4.170.035EDN3, GDNF, RET, BDNF
cell differentiation involved in kidney development (GO:0061005) NEW6.640.001RET, ASCL1, GDNF
noradrenergic neuron development (GO:0003358) -8.630.002PHOX2B, ASCL1
muscle contraction (GO:0006936) -4.370.018EDN3, GDNF, RET, BDNF
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) -5.860.012RET, GDNF, BDNF
cellular component movement (GO:0006928) -2.610.0RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
enteric nervous system development (GO:0048484) -7.330.0PHOX2B, RET, GDNF
sympathetic nervous system development (GO:0048485) -6.960.0PHOX2B, ASCL1, RET, GDNF
neuron migration (GO:0001764) -5.00.009PHOX2B, ASCL1, RET, BDNF
autonomic nervous system development (GO:0048483) -8.120.001PHOX2B, RET, GDNF
regulation of nervous system development (GO:0051960) -3.10.009RET, ASCL1, PHOX2B, BDNF
regulation of cell differentiation (GO:0045595) -2.420.006PHOX2B, ASCL1, GDNF, BDNF, RET
ameboidal cell migration (GO:0001667) -4.710.0EDN3, GDNF, PHOX2B, BDNF, RET
Peyers patch morphogenesis (GO:0061146) NEW8.630.003RET, GDNF
kidney epithelium development (GO:0072073) -5.540.026RET, GDNF, BDNF
positive regulation of metabolic process (GO:0009893) -1.740.004RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of neurogenesis (GO:0050767) -3.210.006PHOX2B, ASCL1, RET, BDNF
positive regulation of cell cycle (GO:0045787) -3.940.003EDN3, ASCL1, PHOX2B, BDNF
regulation of positive chemotaxis (GO:0050926) NEW6.550.002RET, GDNF, BDNF
regulation of neuron differentiation (GO:0045664) -3.390.002RET, PHOX2B, ASCL1, GDNF, BDNF
cellular developmental process (GO:0048869) -1.820.003RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of kinase activity (GO:0043549) NEW3.070.005RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of cell development (GO:0060284) -3.010.0PHOX2B, ASCL1, GDNF, BDNF, RET
cellular component morphogenesis (GO:0032989) -3.50.031PHOX2B, ASCL1, GDNF, BDNF, RET
positive regulation of positive chemotaxis (GO:0050927) NEW6.590.002RET, GDNF, BDNF
regulation of developmental process (GO:0050793) -2.10.001RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of neuron differentiation (GO:0045666) -3.980.001PHOX2B, ASCL1, GDNF, BDNF
lymphocyte migration into lymphoid organs (GO:0097021) NEW8.630.001RET, GDNF
positive regulation of cell development (GO:0010720) -3.570.019ASCL1, GDNF, BDNF
epithelial cell differentiation (GO:0030855) NEW3.980.004EDN3, GDNF, ASCL1, RET, BDNF
neuroepithelial cell differentiation (GO:0060563) NEW6.510.003EDN3, ASCL1, GDNF
cell migration (GO:0016477) -3.120.004RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
ganglion development (GO:0061548) -7.160.011PHOX2B, ASCL1
positive regulation of cellular metabolic process (GO:0031325) -1.810.003RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
columnar/cuboidal epithelial cell differentiation (GO:0002065) NEW5.840.014EDN3, ASCL1, GDNF
positive regulation of cellular component organization (GO:0051130) -2.680.02EDN3, GDNF, RET, BDNF
embryonic epithelial tube formation (GO:0001838) -6.40.019RET, GDNF
response to retinoic acid (GO:0032526) -5.020.005RET, ASCL1, GDNF, BDNF
multicellular organismal process (GO:0032501) -1.450.017RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
neuron differentiation (GO:0030182) -4.170.0RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
sympathetic ganglion development (GO:0061549) -7.530.01PHOX2B, ASCL1
phasic smooth muscle contraction (GO:0014821) -6.960.007EDN3, GDNF
induction of positive chemotaxis (GO:0050930) NEW7.240.0RET, GDNF, BDNF
tissue development (GO:0009888) -3.270.013PHOX2B, ASCL1, RET, BDNF
regulation of kidney development (GO:0090183) -5.720.014RET, ASCL1, GDNF
positive regulation of cell differentiation (GO:0045597) -3.010.011PHOX2B, ASCL1, GDNF, BDNF
regulation of protein kinase activity (GO:0045859) NEW3.150.004RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
mesonephric epithelium development (GO:0072163) -5.80.009RET, GDNF, BDNF
mesonephric tubule development (GO:0072164) -5.820.008RET, GDNF, BDNF
metanephros development (GO:0001656) -6.020.035RET, GDNF
ureteric bud development (GO:0001657) -5.970.046RET, BDNF
neural crest cell migration (GO:0001755) -5.760.0EDN3, PHOX2B, GDNF, RET
nerve development (GO:0021675) NEW6.290.007RET, GDNF, BDNF
regulation of neuron death (GO:1901214) -4.190.021ASCL1, GDNF, BDNF
epithelial tube formation (GO:0072175) -6.360.021RET, GDNF
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.002RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
locomotion (GO:0040011) -2.910.001RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
single-multicellular organism process (GO:0044707) -1.780.015RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
positive regulation of developmental process (GO:0051094) -2.770.001PHOX2B, ASCL1, GDNF, BDNF, RET
cell motility (GO:0048870) -3.020.008RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
muscle system process (GO:0003012) -4.180.048EDN3, GDNF, BDNF, RET
regulation of transferase activity (GO:0051338) NEW2.880.009RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
regulation of metanephros development (GO:0072215) -6.590.015RET, GDNF
regulation of multicellular organismal process (GO:0051239) -1.870.002RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
cellular response to retinoic acid (GO:0071300) NEW5.520.026RET, GDNF, BDNF
regulation of neuron apoptotic process (GO:0043523) -4.470.014RET, ASCL1, GDNF, BDNF
regulation of multicellular organismal development (GO:2000026) -2.310.008PHOX2B, GDNF, ASCL1, RET, BDNF
system development (GO:0048731) -2.920.0PHOX2B, GDNF, ASCL1, RET, BDNF
regulation of protein phosphorylation (GO:0001932) -2.570.023RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116RET, BDNF, EDN3, GDNF, ASCL1, PHOX2B
intracellular part (GO:0044424) 0.284PHOX2B, ASCL1, RET, BDNF
intracellular organelle (GO:0043229) 0.514RET, ASCL1, PHOX2B, BDNF
membrane-bounded organelle (GO:0043227) 0.474PHOX2B, ASCL1, RET, BDNF
organelle (GO:0043226) 0.44PHOX2B, ASCL1, RET, BDNF
intracellular membrane-bounded organelle (GO:0043231) 0.64PHOX2B, ASCL1, RET, BDNF
intracellular organelle part (GO:0044446) 0.813RET, ASCL1, PHOX2B
extracellular region (GO:0005576) 2.183EDN3, GDNF, BDNF
macromolecular complex (GO:0032991) 1.353PHOX2B, ASCL1, RET
organelle part (GO:0044422) 0.793RET, ASCL1, PHOX2B
cytoplasm (GO:0005737) 1.012RET, BDNF
protein complex (GO:0043234) 1.512RET, ASCL1
integral component of membrane (GO:0016021) 1.142RET, BDNF
membrane (GO:0016020) 0.682RET, BDNF
cell body (GO:0044297) 3.742RET, ASCL1
intracellular (GO:0005622) 2.372EDN3, GDNF
neuron part (GO:0097458) 2.642RET, ASCL1
cytoplasmic part (GO:0044444) 0.822RET, BDNF
nuclear part (GO:0044428) 1.552PHOX2B, ASCL1
membrane part (GO:0044425) 0.952RET, BDNF
neuronal cell body (GO:0043025) 3.92RET, ASCL1
nucleus (GO:0005634) 1.072PHOX2B, ASCL1
intrinsic component of membrane (GO:0031224) 1.132RET, BDNF

NET-GE enrichment

Term New enriched termICP valueGenes
cell body (GO:0044297) -3.740.018RET, ASCL1, GDNF, BDNF
neuronal cell body (GO:0043025) -3.90.011RET, ASCL1, GDNF, BDNF