Disease table of SCHIZOPHRENIA OMIM ID: 181500

Gene-disease associations table

GeneAssociated with SCHIZOPHRENIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
DRD3OMIMHGNC link3q13.312PS190300, 181500
DISC1OMIMHGNC link1q42.22181500, 604906
MTHFROMIMHGNC link1p36.225181500, PS188050, 606764, 236250, 601634
DAOOMIMHGNC link12q24.111181500
COMTOMIMHGNC link22q11.212181500, 167870
DAOAOMIMHGNC link13q33.21181500
SETD1AClinVarHGNC link16p11.21181500
AKT1OMIMHGNC link14q32.336167000, 176920, 114480, 181500, 114500, PS158350
DISC2OMIMHGNC link1-1181500
RTN4ROMIMHGNC link22q11.211181500
HTR2AOMIMHGNC link13q14.25103780, 181500, 608516, 164230, 606788
CHI3L1OMIMHGNC link1q32.12611960, 181500
DTNBP1OMIMHGNC link6p22.32181500, PS203300
APOL4OMIMHGNC link22q12.31181500
SYN2OMIMHGNC link3p25.21181500
APOL2OMIMHGNC link22q12.31181500
MC4RClinVarHGNC link18q21.322181500, 601665

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 9422APOL4, APOL2
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
22q11.212COMT, RTN4R
22q12.32APOL4, APOL2
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
22q122APOL4, APOL2
22q112COMT, RTN4R
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
22q14COMT, RTN4R, APOL2, APOL4
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2DISC1, CHI3L1
13q2HTR2A, DAOA
22q4COMT, RTN4R, APOL2, APOL4
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
132HTR2A, DAOA
224COMT, RTN4R, APOL2, APOL4
13CHI3L1, DISC1, MTHFR
32SYN2, DRD3
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122CHI3L1, AKT1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
DISC1YES2ATF4, ATF50
MTHFRYES1NFE2L20
AKT1YES7APC, STAT3, GLI1, AR, TP53, RELA, NFKB10
CHI3L1YES3SP1, STAT3, NFIX0
SYN2YES2ETV4, EGR10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
DISC1COMTNo1XRN2
DISC1AKT1No9CCDC88A, YWHAZ, YWHAE, DCTN1, TUBB, TCL1B, GNB1, YWHAG, SRR
DISC1DTNBP1No17KALRN, RBSN, EXOC1, TRAF3IP1, EXOC7, DCTN1, AKAP6, SYNE1, IFT20, EXOC4, KANSL1, C17ORF59, MACF1, KIF3A, SRGAP3, DST, SYBU
DISC1SYN2No2YWHAE, YWHAZ
MTHFRAPOL2No1GNAZ
DAOSETD1ANo1EP300
DAOAKT1No1EP300
COMTAKT1No1VCP
SETD1AAKT1No2CREBBP, EP300
AKT1DTNBP1No2ARFIP2, DCTN1
AKT1SYN2No2YWHAE, YWHAZ
AKT1MC4RNo1NPM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
DRD3AKT1No-15S1PR3, CCL21, CXCR3, GNAO1, GNGT1, ADORA3, BDNF, GNAI3, CXCL11, APLN, SST, GNAI1, CXCL12, GNB1, S1PR1
DRD3HTR2ANo-26GNG2, LPAR2, LPAR5, GPR17, AGT, BDKRB2, CASR, LPAR3, KNG1, APP, ANXA1, GNB1, MCHR2, NMUR1, BDKRB1, NMU, FPR2, GRM3, LPAR1, NMS, MTRNR2L2, NMUR2, SAA1, GRM2, PMCH, MCHR1
DRD3CHI3L1No-1IL8
DRD3MC4RNo-4POMC, BDNF, GNG2, GNB1
DISC1AKT1No-5CCDC88A, ATF4, GRB2, AXIN1, NRG1
DAODAOAYesbinding0
COMTAKT1No-3UBC, SLC6A4, FOS
COMTHTR2ANo-1FOS
COMTAPOL2No-1UBC
SETD1AAKT1No-3HDAC3, CREBBP, SIRT1
AKT1RTN4RNo-4ARHGDIA, RHOA, HSP90AA1, HSP90AB1
AKT1HTR2ANo-12TACR1, P2RY1, LTB4R, F2R, LTB4R2, TAC1, KISS1, EDN1, GNB1, EDNRA, FOS, GCG
AKT1CHI3L1No-3STAT3, MMP9, IL18
AKT1DTNBP1No-0
AKT1APOL2No-1UBC
AKT1MC4RNo-5GCG, LEP, HSPA8, GNB1, BDNF
HTR2AMC4RNo-8NPS, GNG2, TRH, GNB1, AVP, GCGR, NPSR1, GCG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
SETD1AAKT1No-1HSP90AA1
SETD1ASYN2No-1HSPA8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Dopaminergic synapsehsa047285.693DRD3, COMT, AKT1
Metabolic pathwayshsa011002.493DAO, COMT, MTHFR
Neuroactive ligand-receptor interactionhsa040804.583DRD3, MC4R, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
Dopaminergic synapse (hsa04728) -5.690.039DRD3, COMT, AKT1
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785DRD3, MC4R, RTN4R, HTR2A, AKT1
GPCR downstream signalingR-HSA-3883963.074DRD3, MC4R, HTR2A, AKT1
MetabolismR-HSA-14307282.344DAO, AKT1, MTHFR, COMT
Signaling by GPCRR-HSA-3727902.684DRD3, MC4R, HTR2A, AKT1
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.693DRD3, MC4R, HTR2A
GPCR ligand bindingR-HSA-5007924.193DRD3, MC4R, HTR2A
Amine ligand-binding receptorsR-HSA-3752807.592DRD3, HTR2A
Signalling by NGFR-HSA-1665204.232RTN4R, AKT1
Membrane TraffickingR-HSA-1999915.262DTNBP1, AKT1
Neuronal SystemR-HSA-1123164.822COMT, SYN2
Transmission across Chemical SynapsesR-HSA-1123155.282COMT, SYN2
Vesicle-mediated transportR-HSA-56536564.332DTNBP1, AKT1
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1816DRD3, DAO, COMT, MTHFR, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DAOA, APOL2, DTNBP1
protein binding (GO:0005515) 0.4614DRD3, DAO, MTHFR, COMT, APOL4, MC4R, RTN4R, HTR2A, SETD1A, AKT1, DISC1, DTNBP1, APOL2, DAOA
organic cyclic compound binding (GO:0097159) 1.058DRD3, DAO, MTHFR, HTR2A, SETD1A, SYN2, AKT1, DISC1
catalytic activity (GO:0003824) 1.057CHI3L1, DAO, MTHFR, COMT, SYN2, SETD1A, AKT1
heterocyclic compound binding (GO:1901363) 1.067DAO, MTHFR, HTR2A, SETD1A, SYN2, AKT1, DISC1
small molecule binding (GO:0036094) 1.895AKT1, SETD1A, DAO, SYN2, MTHFR
nucleoside phosphate binding (GO:1901265) 1.965SYN2, SETD1A, DAO, AKT1, MTHFR
nucleotide binding (GO:0000166) 1.965AKT1, SETD1A, DAO, SYN2, MTHFR
signaling receptor activity (GO:0038023) 2.494DRD3, RTN4R, MC4R, HTR2A
molecular transducer activity (GO:0060089) 2.324DRD3, RTN4R, MC4R, HTR2A
transmembrane signaling receptor activity (GO:0004888) 2.574DRD3, RTN4R, MC4R, HTR2A
macromolecular complex binding (GO:0044877) 2.614APOL2, DISC1, HTR2A, MTHFR
receptor activity (GO:0004872) 2.324DRD3, RTN4R, MC4R, HTR2A
signal transducer activity (GO:0004871) 2.284DRD3, RTN4R, MC4R, HTR2A
transmembrane receptor activity (GO:0099600) 2.534DRD3, RTN4R, MC4R, HTR2A
G-protein coupled receptor activity (GO:0004930) 2.953DRD3, MC4R, HTR2A
carbohydrate derivative binding (GO:0097367) 2.033CHI3L1, SYN2, AKT1
enzyme regulator activity (GO:0030234) 2.853DAOA, RTN4R, AKT1
lipid binding (GO:0008289) 3.263APOL2, APOL4, AKT1
enzyme binding (GO:0019899) 2.273DAOA, MC4R, AKT1
transferase activity (GO:0016740) 1.953SETD1A, COMT, AKT1
protein complex binding (GO:0032403) 3.093DISC1, HTR2A, MTHFR
receptor binding (GO:0005102) 2.433APOL2, DRD3, DAO
molecular function regulator (GO:0098772) 2.513DAOA, RTN4R, AKT1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222SYN2, AKT1
drug binding (GO:0008144) 5.032DRD3, HTR2A
nucleic acid binding (GO:0003676) 1.442SETD1A, DISC1
methyltransferase activity (GO:0008168) 4.352SETD1A, COMT
ion binding (GO:0043167) 1.362COMT, AKT1
purine nucleoside binding (GO:0001883) 2.222SYN2, AKT1
nucleoside binding (GO:0001882) 2.212SYN2, AKT1
coenzyme binding (GO:0050662) 4.532DAO, MTHFR
flavin adenine dinucleotide binding (GO:0050660) 5.412DAO, MTHFR
structural molecule activity (GO:0005198) 3.12CHI3L1, DISC1
transferase activity, transferring one-carbon groups (GO:0016741) 4.32SETD1A, COMT
ribonucleoside binding (GO:0032549) 2.222SYN2, AKT1
purine nucleotide binding (GO:0017076) 2.192SYN2, AKT1
oxidoreductase activity (GO:0016491) 3.122DAO, MTHFR
ATP binding (GO:0005524) 2.432SYN2, AKT1
S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) 4.812SETD1A, COMT
cofactor binding (GO:0048037) 4.162DAO, MTHFR
adenyl nucleotide binding (GO:0030554) 2.42SYN2, AKT1
adenyl ribonucleotide binding (GO:0032559) 2.412SYN2, AKT1
purine ribonucleotide binding (GO:0032555) 2.22SYN2, AKT1
purine ribonucleoside binding (GO:0032550) 2.222SYN2, AKT1
ribonucleotide binding (GO:0032553) 2.192SYN2, AKT1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.4814DRD3, DAO, MTHFR, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SYN2, AKT1, DISC1, DTNBP1, APOL2
cellular process (GO:0009987) 0.2613DRD3, DAO, COMT, MTHFR, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1
biological regulation (GO:0065007) 0.3913DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DTNBP1, DAOA
single-organism cellular process (GO:0044763) 0.6512DRD3, DAO, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SYN2, AKT1, DISC1, DTNBP1
regulation of biological process (GO:0050789) 0.4512DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1, DAOA
regulation of metabolic process (GO:0019222) 1.0212DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1, DAOA
regulation of cellular metabolic process (GO:0031323) 1.0711DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1
regulation of primary metabolic process (GO:0080090) 1.0811DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1
regulation of cellular process (GO:0050794) 0.511DRD3, DISC1, MTHFR, COMT, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1
response to stimulus (GO:0050896) 1.2210DRD3, DISC1, MTHFR, COMT, MC4R, CHI3L1, HTR2A, AKT1, DTNBP1, APOL2
localization (GO:0051179) 1.410DRD3, DISC1, MC4R, APOL4, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1, APOL2
metabolic process (GO:0008152) 0.5810DRD3, DAO, MTHFR, COMT, MC4R, APOL4, CHI3L1, SETD1A, AKT1, APOL2
multicellular organismal process (GO:0032501) 1.459DRD3, DISC1, MTHFR, COMT, MC4R, HTR2A, AKT1, DTNBP1, APOL2
regulation of macromolecule metabolic process (GO:0060255) 1.089DRD3, DISC1, MTHFR, RTN4R, CHI3L1, HTR2A, SETD1A, AKT1, DTNBP1
transport (GO:0006810) 1.519DRD3, MC4R, APOL4, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1, APOL2
organic substance metabolic process (GO:0071704) 0.639DRD3, DAO, MTHFR, COMT, APOL4, CHI3L1, SETD1A, AKT1, APOL2
single-organism transport (GO:0044765) 2.189DRD3, MC4R, APOL4, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1, APOL2
establishment of localization (GO:0051234) 1.489DRD3, MC4R, APOL4, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1, APOL2
single-organism localization (GO:1902578) 2.099DRD3, MC4R, APOL4, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1, APOL2
developmental process (GO:0032502) 1.368CHI3L1, DISC1, COMT, RTN4R, HTR2A, AKT1, DTNBP1, APOL2
positive regulation of metabolic process (GO:0009893) 1.748DRD3, DISC1, COMT, MC4R, CHI3L1, HTR2A, AKT1, DTNBP1
single-multicellular organism process (GO:0044707) 1.788DRD3, DISC1, COMT, MC4R, HTR2A, AKT1, DTNBP1, APOL2
regulation of multicellular organismal process (GO:0051239) 1.878DRD3, DISC1, COMT, MC4R, RTN4R, CHI3L1, HTR2A, AKT1
positive regulation of biological process (GO:0048518) 1.28DRD3, DISC1, COMT, MC4R, CHI3L1, HTR2A, AKT1, DTNBP1
regulation of biological quality (GO:0065008) 1.688DRD3, DISC1, COMT, MC4R, HTR2A, SYN2, AKT1, DTNBP1
positive regulation of cellular process (GO:0048522) 1.38DRD3, DISC1, COMT, MC4R, CHI3L1, HTR2A, AKT1, DTNBP1
regulation of signaling (GO:0023051) 1.727DRD3, DISC1, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
primary metabolic process (GO:0044238) 0.697CHI3L1, DAO, MTHFR, APOL4, SETD1A, AKT1, APOL2
single-organism metabolic process (GO:0044710) 1.637DRD3, DAO, MTHFR, MC4R, APOL4, AKT1, APOL2
regulation of cellular protein metabolic process (GO:0032268) 1.997CHI3L1, DISC1, MTHFR, RTN4R, HTR2A, AKT1, DTNBP1
regulation of phosphate metabolic process (GO:0019220) 2.357DRD3, MC4R, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
regulation of signal transduction (GO:0009966) 1.847DRD3, DISC1, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
regulation of response to stimulus (GO:0048583) 1.547DRD3, DISC1, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
positive regulation of cellular metabolic process (GO:0031325) 1.817DRD3, DISC1, COMT, MC4R, CHI3L1, HTR2A, AKT1
regulation of catalytic activity (GO:0050790) 1.977DRD3, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1, DAOA
regulation of protein metabolic process (GO:0051246) 1.937CHI3L1, DISC1, MTHFR, RTN4R, HTR2A, AKT1, DTNBP1
cellular metabolic process (GO:0044237) 0.697DRD3, DAO, MTHFR, COMT, MC4R, SETD1A, AKT1
single-organism developmental process (GO:0044767) 1.497CHI3L1, DISC1, RTN4R, HTR2A, AKT1, DTNBP1, APOL2
nitrogen compound metabolic process (GO:0006807) 1.137DRD3, DAO, MTHFR, COMT, CHI3L1, SETD1A, AKT1
regulation of phosphorus metabolic process (GO:0051174) 2.357DRD3, MC4R, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
negative regulation of biological process (GO:0048519) 1.337DRD3, COMT, MC4R, RTN4R, HTR2A, AKT1, DAOA
regulation of protein modification process (GO:0031399) 2.327CHI3L1, DISC1, MTHFR, RTN4R, HTR2A, AKT1, DTNBP1
response to chemical (GO:0042221) 1.987DRD3, MTHFR, COMT, MC4R, CHI3L1, HTR2A, AKT1
regulation of molecular function (GO:0065009) 1.787DRD3, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1, DAOA
regulation of cell communication (GO:0010646) 1.737DRD3, DISC1, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
response to abiotic stimulus (GO:0009628) 2.86DRD3, DISC1, MTHFR, CHI3L1, HTR2A, AKT1
organonitrogen compound metabolic process (GO:1901564) 2.326DRD3, DAO, MTHFR, COMT, CHI3L1, AKT1
positive regulation of macromolecule metabolic process (GO:0010604) 1.816DRD3, DISC1, CHI3L1, HTR2A, AKT1, DTNBP1
response to external stimulus (GO:0009605) 2.556DRD3, MTHFR, COMT, CHI3L1, HTR2A, AKT1
positive regulation of multicellular organismal process (GO:0051240) 2.496DRD3, DISC1, MC4R, CHI3L1, HTR2A, AKT1
cellular component organization (GO:0016043) 1.246DISC1, MTHFR, RTN4R, SETD1A, AKT1, DTNBP1
macromolecule metabolic process (GO:0043170) 0.836DRD3, APOL4, CHI3L1, SETD1A, AKT1, APOL2
positive regulation of signaling (GO:0023056) 2.416DRD3, DISC1, CHI3L1, HTR2A, AKT1, DTNBP1
signal transduction (GO:0007165) 1.286DRD3, DISC1, MC4R, RTN4R, HTR2A, AKT1
organic substance transport (GO:0071702) 2.156DRD3, MC4R, APOL4, CHI3L1, AKT1, APOL2
cellular component organization or biogenesis (GO:0071840) 1.226DISC1, MTHFR, RTN4R, SETD1A, AKT1, DTNBP1
positive regulation of cell communication (GO:0010647) 2.416DRD3, DISC1, CHI3L1, HTR2A, AKT1, DTNBP1
regulation of intracellular signal transduction (GO:1902531) 2.316DRD3, RTN4R, CHI3L1, HTR2A, AKT1, DTNBP1
response to organic substance (GO:0010033) 2.26DRD3, MTHFR, COMT, MC4R, CHI3L1, AKT1
organic cyclic compound metabolic process (GO:1901360) 1.266DRD3, DAO, MTHFR, COMT, SETD1A, APOL2
regulation of nitrogen compound metabolic process (GO:0051171) 1.366DRD3, COMT, MC4R, HTR2A, SETD1A, AKT1
protein localization (GO:0008104) 2.365AKT1, CHI3L1, DISC1, MC4R, HTR2A
negative regulation of metabolic process (GO:0009892) 1.935DAOA, RTN4R, DRD3, AKT1, COMT
regulation of transport (GO:0051049) 2.245DRD3, DTNBP1, COMT, HTR2A, AKT1
positive regulation of response to stimulus (GO:0048584) 2.185AKT1, DRD3, DISC1, CHI3L1, HTR2A
regulation of cellular component organization (GO:0051128) 2.015DISC1, DRD3, RTN4R, AKT1, MTHFR
positive regulation of catalytic activity (GO:0043085) 2.45DAOA, CHI3L1, RTN4R, HTR2A, AKT1
positive regulation of signal transduction (GO:0009967) 2.55DRD3, CHI3L1, DISC1, HTR2A, AKT1
regulation of kinase activity (GO:0043549) 3.075CHI3L1, DTNBP1, RTN4R, HTR2A, AKT1
regulation of developmental process (GO:0050793) 2.15RTN4R, DRD3, DISC1, CHI3L1, AKT1
positive regulation of molecular function (GO:0044093) 2.235DAOA, CHI3L1, RTN4R, HTR2A, AKT1
regulation of cellular biosynthetic process (GO:0031326) 1.385SETD1A, MC4R, HTR2A, AKT1, DRD3
macromolecule localization (GO:0033036) 2.345MC4R, CHI3L1, DISC1, HTR2A, AKT1
regulation of cell proliferation (GO:0042127) 2.415AKT1, DRD3, DISC1, COMT, HTR2A
regulation of phosphorylation (GO:0042325) 2.55CHI3L1, DTNBP1, RTN4R, HTR2A, AKT1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435SETD1A, MC4R, HTR2A, AKT1, DRD3
cellular aromatic compound metabolic process (GO:0006725) 1.35SETD1A, DAO, DRD3, MTHFR, COMT
regulation of protein kinase activity (GO:0045859) 3.155CHI3L1, DTNBP1, RTN4R, HTR2A, AKT1
regulation of biosynthetic process (GO:0009889) 1.375SETD1A, MC4R, HTR2A, AKT1, DRD3
response to stress (GO:0006950) 1.85CHI3L1, APOL2, AKT1, MTHFR, COMT
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.295MC4R, COMT, HTR2A, AKT1, DRD3
regulation of localization (GO:0032879) 1.945DRD3, DTNBP1, COMT, HTR2A, AKT1
system process (GO:0003008) 2.35HTR2A, DRD3, COMT, AKT1, MTHFR
response to oxygen-containing compound (GO:1901700) 2.575DRD3, MC4R, COMT, AKT1, MTHFR
regulation of cell differentiation (GO:0045595) 2.425DISC1, DRD3, RTN4R, HTR2A, AKT1
regulation of transferase activity (GO:0051338) 2.885CHI3L1, DTNBP1, RTN4R, HTR2A, AKT1
regulation of multicellular organismal development (GO:2000026) 2.315RTN4R, DRD3, DISC1, CHI3L1, AKT1
regulation of protein phosphorylation (GO:0001932) 2.575CHI3L1, DTNBP1, RTN4R, HTR2A, AKT1
negative regulation of cellular process (GO:0048523) 1.415DRD3, RTN4R, HTR2A, AKT1, COMT
positive regulation of protein modification process (GO:0031401) 2.74CHI3L1, DISC1, AKT1, HTR2A
regulation of secretion (GO:0051046) 3.24DTNBP1, COMT, DRD3, HTR2A
positive regulation of biosynthetic process (GO:0009891) 2.294DRD3, MC4R, HTR2A, AKT1
cell projection organization (GO:0030030) 3.144RTN4R, DTNBP1, DISC1, AKT1
negative regulation of cellular metabolic process (GO:0031324) 2.014DRD3, RTN4R, COMT, AKT1
behavior (GO:0007610) 3.474DRD3, COMT, MC4R, HTR2A
regulation of homeostatic process (GO:0032844) 3.654MC4R, COMT, HTR2A, DRD3
homeostatic process (GO:0042592) 2.614DRD3, DISC1, AKT1, HTR2A
negative regulation of signaling (GO:0023057) 2.654DRD3, RTN4R, HTR2A, AKT1
small molecule metabolic process (GO:0044281) 2.384APOL2, DAO, AKT1, MTHFR
regulation of protein serine/threonine kinase activity (GO:0071900) 3.584CHI3L1, DTNBP1, HTR2A, AKT1
negative regulation of catalytic activity (GO:0043086) 3.04DAOA, RTN4R, DRD3, AKT1
response to organic cyclic compound (GO:0014070) 3.074DRD3, COMT, AKT1, MTHFR
regulation of MAPK cascade (GO:0043408) 3.224CHI3L1, DTNBP1, HTR2A, AKT1
response to endogenous stimulus (GO:0009719) 2.794DRD3, MC4R, AKT1, MTHFR
regulation of neurogenesis (GO:0050767) 3.214DISC1, DRD3, RTN4R, AKT1
organic substance catabolic process (GO:1901575) 2.454CHI3L1, DAO, COMT, AKT1
positive regulation of phosphate metabolic process (GO:0045937) 2.784CHI3L1, MC4R, HTR2A, AKT1
regulation of system process (GO:0044057) 3.534DRD3, COMT, HTR2A, AKT1
response to nitrogen compound (GO:1901698) 3.124DRD3, MC4R, AKT1, MTHFR
positive regulation of phosphorus metabolic process (GO:0010562) 2.784MC4R, CHI3L1, HTR2A, AKT1
positive regulation of cellular biosynthetic process (GO:0031328) 2.34DRD3, MC4R, HTR2A, AKT1
positive regulation of protein metabolic process (GO:0051247) 2.434CHI3L1, DISC1, HTR2A, AKT1
regulation of cell development (GO:0060284) 3.014DISC1, DRD3, RTN4R, AKT1
positive regulation of cellular protein metabolic process (GO:0032270) 2.494CHI3L1, DISC1, AKT1, HTR2A
negative regulation of molecular function (GO:0044092) 2.744DRD3, RTN4R, DAOA, AKT1
G-protein coupled receptor signaling pathway (GO:0007186) 2.644DRD3, MC4R, HTR2A, AKT1
regulation of gene expression (GO:0010468) 1.374SETD1A, DTNBP1, DRD3, AKT1
positive regulation of cell proliferation (GO:0008284) 3.014DRD3, DISC1, AKT1, HTR2A
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354DRD3, MC4R, HTR2A, AKT1
negative regulation of transport (GO:0051051) 3.64DRD3, COMT, HTR2A, AKT1
establishment of localization in cell (GO:0051649) 2.474SYN2, DTNBP1, HTR2A, AKT1
cell communication (GO:0007154) 3.044DRD3, COMT, HTR2A, SYN2
catabolic process (GO:0009056) 2.384CHI3L1, DAO, COMT, AKT1
oxidation-reduction process (GO:0055114) 2.914MC4R, DAO, AKT1, MTHFR
cellular localization (GO:0051641) 2.324DTNBP1, DISC1, HTR2A, AKT1
secretion (GO:0046903) 3.384MC4R, CHI3L1, DRD3, SYN2
response to organonitrogen compound (GO:0010243) 3.24DRD3, MC4R, AKT1, MTHFR
anatomical structure development (GO:0048856) 1.584DISC1, CHI3L1, APOL2, AKT1
response to drug (GO:0042493) 3.714DRD3, COMT, HTR2A, MTHFR
chemical homeostasis (GO:0048878) 2.974DRD3, DISC1, HTR2A, AKT1
regulation of nervous system development (GO:0051960) 3.14RTN4R, DRD3, DISC1, AKT1
negative regulation of cell communication (GO:0010648) 2.664DRD3, RTN4R, HTR2A, AKT1
organic hydroxy compound metabolic process (GO:1901615) 3.844DAO, DRD3, APOL2, COMT
regulation of growth (GO:0040008) 3.264DISC1, DRD3, RTN4R, AKT1
regulation of neurotransmitter levels (GO:0001505) 4.774DRD3, DTNBP1, COMT, SYN2
negative regulation of response to stimulus (GO:0048585) 2.523DRD3, RTN4R, AKT1
learning or memory (GO:0007611) 4.333DRD3, COMT, HTR2A
circulatory system process (GO:0003013) 4.383HTR2A, AKT1, MTHFR
calcium ion homeostasis (GO:0055074) 3.973DRD3, DISC1, HTR2A
cell surface receptor signaling pathway (GO:0007166) 2.093DISC1, RTN4R, AKT1
inorganic ion homeostasis (GO:0098771) 3.433DRD3, DISC1, HTR2A
regulation of cell projection organization (GO:0031344) 3.383DISC1, RTN4R, AKT1
cellular response to stimulus (GO:0051716) 1.973CHI3L1, COMT, AKT1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013DRD3, RTN4R, AKT1
negative regulation of signal transduction (GO:0009968) 2.753DRD3, RTN4R, AKT1
cellular developmental process (GO:0048869) 1.823DTNBP1, RTN4R, AKT1
lipid transport (GO:0006869) 4.243APOL2, DRD3, APOL4
response to mechanical stimulus (GO:0009612) 4.413CHI3L1, HTR2A, AKT1
regulation of neuron differentiation (GO:0045664) 3.393RTN4R, DISC1, AKT1
regulation of amine transport (GO:0051952) 5.623DRD3, DTNBP1, HTR2A
cellular homeostasis (GO:0019725) 3.233DRD3, DISC1, HTR2A
positive regulation of transport (GO:0051050) 2.93DRD3, DTNBP1, AKT1
establishment of protein localization (GO:0045184) 2.533MC4R, CHI3L1, AKT1
regulation of neuron projection development (GO:0010975) 3.693RTN4R, DISC1, AKT1
regulation of RNA biosynthetic process (GO:2001141) 1.553SETD1A, DRD3, AKT1
multi-organism process (GO:0051704) 2.653DRD3, COMT, HTR2A
single organism signaling (GO:0044700) 3.253DRD3, SYN2, HTR2A
positive regulation of phosphorylation (GO:0042327) 2.93CHI3L1, HTR2A, AKT1
organonitrogen compound catabolic process (GO:1901565) 3.913CHI3L1, DAO, COMT
single-organism behavior (GO:0044708) 3.793DRD3, COMT, HTR2A
response to nutrient levels (GO:0031667) 3.773COMT, AKT1, MTHFR
anterograde trans-synaptic signaling (GO:0098916) 3.983DRD3, SYN2, HTR2A
positive regulation of catabolic process (GO:0009896) 3.943DISC1, AKT1, HTR2A
regulation of catabolic process (GO:0009894) 3.523DISC1, AKT1, HTR2A
regulation of anatomical structure morphogenesis (GO:0022603) 2.793RTN4R, CHI3L1, DISC1
secretion by cell (GO:0032940) 3.593CHI3L1, MC4R, SYN2
positive regulation of gene expression (GO:0010628) 2.353DRD3, DTNBP1, AKT1
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.063CHI3L1, HTR2A, AKT1
intracellular signal transduction (GO:0035556) 2.393DISC1, AKT1, HTR2A
organic substance biosynthetic process (GO:1901576) 1.343SETD1A, DAO, AKT1
positive regulation of transferase activity (GO:0051347) 3.313CHI3L1, HTR2A, AKT1
positive regulation of hydrolase activity (GO:0051345) 2.913RTN4R, HTR2A, AKT1
negative regulation of phosphate metabolic process (GO:0045936) 3.453DRD3, RTN4R, AKT1
positive regulation of cellular component organization (GO:0051130) 2.683DRD3, DISC1, AKT1
response to cytokine (GO:0034097) 3.843CHI3L1, AKT1, MTHFR
catecholamine metabolic process (GO:0006584) 6.023DRD3, DAO, COMT
regulation of behavior (GO:0050795) 5.553DRD3, MC4R, HTR2A
defense response (GO:0006952) 2.783CHI3L1, APOL2, AKT1
inflammatory response (GO:0006954) 3.643CHI3L1, APOL2, AKT1
negative regulation of intracellular signal transduction (GO:1902532) 3.633DRD3, RTN4R, AKT1
neurological system process (GO:0050877) 2.643DRD3, COMT, HTR2A
regulation of hydrolase activity (GO:0051336) 2.533RTN4R, HTR2A, AKT1
cognition (GO:0050890) 4.23DRD3, COMT, HTR2A
regulation of transcription, DNA-templated (GO:0006355) 1.563SETD1A, DRD3, AKT1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433SETD1A, DRD3, AKT1
positive regulation of kinase activity (GO:0033674) 3.543CHI3L1, HTR2A, AKT1
synaptic signaling (GO:0099536) 3.983DRD3, SYN2, HTR2A
trans-synaptic signaling (GO:0099537) 3.983DRD3, HTR2A, SYN2
regulation of developmental growth (GO:0048638) 4.043RTN4R, DRD3, DISC1
negative regulation of multicellular organismal process (GO:0051241) 2.843DRD3, RTN4R, COMT
regulation of organelle organization (GO:0033043) 2.723DRD3, AKT1, MTHFR
ion homeostasis (GO:0050801) 3.423DRD3, DISC1, HTR2A
chemical synaptic transmission (GO:0007268) 3.983DRD3, HTR2A, SYN2
modulation of synaptic transmission (GO:0050804) 4.093DRD3, DTNBP1, HTR2A
cellular biosynthetic process (GO:0044249) 1.373SETD1A, DAO, AKT1
cellular nitrogen compound metabolic process (GO:0034641) 1.223SETD1A, AKT1, MTHFR
signaling (GO:0023052) 3.253DRD3, HTR2A, SYN2
regulation of secretion by cell (GO:1903530) 3.283DRD3, DTNBP1, HTR2A
regulation of catecholamine secretion (GO:0050433) 5.993DRD3, DTNBP1, HTR2A
divalent inorganic cation homeostasis (GO:0072507) 3.93DRD3, DISC1, HTR2A
cellular divalent inorganic cation homeostasis (GO:0072503) 3.963DRD3, DISC1, HTR2A
negative regulation of phosphorus metabolic process (GO:0010563) 3.453DRD3, RTN4R, AKT1
regulation of nucleotide metabolic process (GO:0006140) 4.383DRD3, MC4R, HTR2A
multicellular organismal reproductive process (GO:0048609) 3.353APOL2, COMT, AKT1
cellular metal ion homeostasis (GO:0006875) 3.753DRD3, DISC1, HTR2A
positive regulation of cellular catabolic process (GO:0031331) 4.153DISC1, AKT1, HTR2A
cellular ion homeostasis (GO:0006873) 3.573DRD3, DISC1, HTR2A
dopamine metabolic process (GO:0042417) 6.513DRD3, DAO, COMT
negative regulation of ion transport (GO:0043271) 4.943DRD3, HTR2A, AKT1
regulation of cell growth (GO:0001558) 3.753RTN4R, DISC1, AKT1
cellular cation homeostasis (GO:0030003) 3.63DRD3, DISC1, HTR2A
cation homeostasis (GO:0055080) 3.463DRD3, DISC1, HTR2A
phenol-containing compound metabolic process (GO:0018958) 5.333DRD3, DAO, COMT
cellular chemical homeostasis (GO:0055082) 3.43DRD3, DISC1, HTR2A
regulation of RNA metabolic process (GO:0051252) 1.523SETD1A, DRD3, AKT1
regulation of cellular catabolic process (GO:0031329) 3.833DISC1, HTR2A, AKT1
positive regulation of protein kinase activity (GO:0045860) 3.613CHI3L1, HTR2A, AKT1
response to extracellular stimulus (GO:0009991) 3.713COMT, AKT1, MTHFR
regulation of cellular localization (GO:0060341) 3.033DRD3, DTNBP1, AKT1
regulation of dopamine secretion (GO:0014059) 6.643DRD3, DTNBP1, HTR2A
cell death (GO:0008219) 3.053CHI3L1, HTR2A, AKT1
multicellular organism development (GO:0007275) 2.543DISC1, APOL2, AKT1
regulation of ion transport (GO:0043269) 3.43DRD3, HTR2A, AKT1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463SETD1A, DRD3, AKT1
cellular calcium ion homeostasis (GO:0006874) 4.013DRD3, DISC1, HTR2A
regulation of lipid metabolic process (GO:0019216) 4.083DRD3, HTR2A, AKT1
regulation of hormone levels (GO:0010817) 3.563MC4R, COMT, HTR2A
regulation of metal ion transport (GO:0010959) 3.943DRD3, HTR2A, AKT1
reproductive process (GO:0022414) 2.553APOL2, COMT, AKT1
biosynthetic process (GO:0009058) 1.323SETD1A, DAO, AKT1
regulation of nucleic acid-templated transcription (GO:1903506) 1.553SETD1A, DRD3, AKT1
metal ion homeostasis (GO:0055065) 3.613DRD3, DISC1, HTR2A
cell-cell signaling (GO:0007267) 3.353DRD3, HTR2A, SYN2
organelle organization (GO:0006996) 2.023DTNBP1, DISC1, AKT1
positive regulation of cell differentiation (GO:0045597) 3.013DISC1, HTR2A, AKT1
regulation of purine nucleotide metabolic process (GO:1900542) 4.413DRD3, MC4R, HTR2A
cellular macromolecule metabolic process (GO:0044260) 0.933SETD1A, DRD3, AKT1
regulation of ion homeostasis (GO:2000021) 4.443DRD3, COMT, HTR2A
protein transport (GO:0015031) 2.623CHI3L1, MC4R, AKT1
catechol-containing compound metabolic process (GO:0009712) 6.023DRD3, DAO, COMT
positive regulation of protein phosphorylation (GO:0001934) 2.953CHI3L1, HTR2A, AKT1
positive regulation of vasoconstriction (GO:0045907) 6.122HTR2A, AKT1
positive regulation of secretion (GO:0051047) 3.852DRD3, DTNBP1
negative regulation of secretion (GO:0051048) 4.442DRD3, COMT
learning (GO:0007612) 4.852DRD3, COMT
positive regulation of homeostatic process (GO:0032846) 4.382DRD3, MC4R
negative regulation of homeostatic process (GO:0032845) 4.912COMT, HTR2A
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) 4.972DRD3, DTNBP1
vascular process in circulatory system (GO:0003018) 4.652HTR2A, AKT1
regulation of ion transmembrane transport (GO:0034765) 3.772DRD3, AKT1
negative regulation of ion transmembrane transport (GO:0034766) 5.472DRD3, AKT1
regulation of anatomical structure size (GO:0090066) 3.782HTR2A, AKT1
organic cyclic compound biosynthetic process (GO:1901362) 1.662SETD1A, DAO
positive regulation of nucleotide metabolic process (GO:0045981) 4.852MC4R, HTR2A
regulation of transmembrane transport (GO:0034762) 3.742DRD3, AKT1
negative regulation of transmembrane transport (GO:0034763) 5.382DRD3, AKT1
positive regulation of cell cycle (GO:0045787) 3.942DRD3, AKT1
positive regulation of cell adhesion (GO:0045785) 3.792DISC1, AKT1
peptidyl-amino acid modification (GO:0018193) 2.982SETD1A, AKT1
animal organ development (GO:0048513) 2.532CHI3L1, AKT1
positive regulation of lipid metabolic process (GO:0045834) 4.882HTR2A, AKT1
negative regulation of cell development (GO:0010721) 4.022DRD3, RTN4R
heterocycle metabolic process (GO:0046483) 1.312SETD1A, MTHFR
cytoskeleton organization (GO:0007010) 3.222DTNBP1, DISC1
regulation of vasoconstriction (GO:0019229) 5.512HTR2A, AKT1
negative regulation of phosphorylation (GO:0042326) 3.72RTN4R, AKT1
regulation of proteolysis (GO:0030162) 3.22DISC1, AKT1
oxoacid metabolic process (GO:0043436) 3.122DAO, MTHFR
regulation of axon extension (GO:0030516) 5.242RTN4R, DISC1
response to peptide hormone (GO:0043434) 4.062MC4R, AKT1
cell part morphogenesis (GO:0032990) 3.992DTNBP1, RTN4R
regulation of axonogenesis (GO:0050770) 4.592RTN4R, DISC1
single organism reproductive process (GO:0044702) 2.732APOL2, AKT1
vesicle-mediated transport (GO:0016192) 2.722DRD3, DTNBP1
organonitrogen compound biosynthetic process (GO:1901566) 2.852DAO, AKT1
protein metabolic process (GO:0019538) 1.452SETD1A, AKT1
regulation of MAP kinase activity (GO:0043405) 3.952DTNBP1, HTR2A
regulation of purine nucleotide biosynthetic process (GO:1900371) 4.82DRD3, MC4R
response to insulin (GO:0032868) 4.722MC4R, AKT1
cellular response to stress (GO:0033554) 2.512COMT, AKT1
aromatic compound biosynthetic process (GO:0019438) 1.72SETD1A, DAO
negative regulation of kinase activity (GO:0033673) 4.222RTN4R, AKT1
cellular macromolecule biosynthetic process (GO:0034645) 1.662SETD1A, AKT1
movement of cell or subcellular component (GO:0006928) 2.612DTNBP1, DISC1
negative regulation of gene expression (GO:0010629) 2.482DRD3, AKT1
lipoprotein metabolic process (GO:0042157) 5.822APOL2, APOL4
regulation of neurotransmitter transport (GO:0051588) 5.552DRD3, DTNBP1
cellular protein metabolic process (GO:0044267) 1.632SETD1A, AKT1
regulation of oxidoreductase activity (GO:0051341) 5.272DAOA, AKT1
anatomical structure morphogenesis (GO:0009653) 2.532DTNBP1, RTN4R
negative regulation of transferase activity (GO:0051348) 3.872RTN4R, AKT1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792DISC1, AKT1
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.782DRD3, MC4R
energy reserve metabolic process (GO:0006112) 5.442MC4R, AKT1
positive regulation of carbohydrate metabolic process (GO:0045913) 5.42HTR2A, AKT1
methylation (GO:0032259) 4.062SETD1A, COMT
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62DRD3, MC4R
regulation of tube size (GO:0035150) 4.792HTR2A, AKT1
regulation of establishment of protein localization (GO:0070201) 3.022DRD3, AKT1
cellular protein localization (GO:0034613) 3.112DISC1, HTR2A
lipid metabolic process (GO:0006629) 2.682APOL2, APOL4
protein secretion (GO:0009306) 4.972MC4R, CHI3L1
ion transport (GO:0006811) 2.662DRD3, HTR2A
positive regulation of MAPK cascade (GO:0043410) 3.572CHI3L1, HTR2A
programmed cell death (GO:0012501) 3.12CHI3L1, AKT1
macromolecule modification (GO:0043412) 1.732SETD1A, AKT1
protein modification process (GO:0036211) 1.792SETD1A, AKT1
regulation of blood circulation (GO:1903522) 4.052HTR2A, AKT1
signal release (GO:0023061) 4.652MC4R, SYN2
response to temperature stimulus (GO:0009266) 4.712HTR2A, AKT1
positive regulation of intracellular signal transduction (GO:1902533) 2.952CHI3L1, HTR2A
phosphatidylinositol-mediated signaling (GO:0048015) 4.932HTR2A, AKT1
inositol lipid-mediated signaling (GO:0048017) 4.912HTR2A, AKT1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592SETD1A, AKT1
energy derivation by oxidation of organic compounds (GO:0015980) 4.932MC4R, AKT1
intracellular transport (GO:0046907) 2.672DTNBP1, AKT1
cellular response to cytokine stimulus (GO:0071345) 4.332CHI3L1, AKT1
response to decreased oxygen levels (GO:0036293) 4.092AKT1, MTHFR
regulation of response to stress (GO:0080134) 2.532DTNBP1, AKT1
regulation of cellular response to stress (GO:0080135) 3.42DTNBP1, AKT1
positive regulation of blood circulation (GO:1903524) 5.162HTR2A, AKT1
positive regulation of protein catabolic process (GO:0045732) 4.182DISC1, AKT1
negative regulation of nervous system development (GO:0051961) 4.152DRD3, RTN4R
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242DRD3, AKT1
cellular amide metabolic process (GO:0043603) 3.232AKT1, MTHFR
aminoglycan metabolic process (GO:0006022) 4.622CHI3L1, AKT1
regulation of carbohydrate metabolic process (GO:0006109) 4.572HTR2A, AKT1
positive regulation of proteolysis (GO:0045862) 3.862DISC1, AKT1
regulation of cell morphogenesis (GO:0022604) 3.42RTN4R, DISC1
behavioral response to cocaine (GO:0048148) 7.242DRD3, HTR2A
response to radiation (GO:0009314) 3.692DRD3, AKT1
regulation of cell adhesion (GO:0030155) 3.272DISC1, AKT1
negative regulation of cellular component organization (GO:0051129) 3.352RTN4R, AKT1
cellular catabolic process (GO:0044248) 2.622DAO, COMT
regulation of protein catabolic process (GO:0042176) 3.832DISC1, AKT1
response to light stimulus (GO:0009416) 4.082DRD3, AKT1
cellular response to chemical stimulus (GO:0070887) 2.572CHI3L1, AKT1
response to hypoxia (GO:0001666) 4.132AKT1, MTHFR
regulation of protein localization (GO:0032880) 2.882DRD3, AKT1
regulation of extent of cell growth (GO:0061387) 5.092RTN4R, DISC1
negative regulation of protein metabolic process (GO:0051248) 2.822RTN4R, AKT1
regulation of blood vessel size (GO:0050880) 4.82HTR2A, AKT1
regulation of cAMP biosynthetic process (GO:0030817) 5.012DRD3, MC4R
regulation of cAMP metabolic process (GO:0030814) 4.882DRD3, MC4R
regulation of cell cycle process (GO:0010564) 3.52DRD3, AKT1
negative regulation of neurogenesis (GO:0050768) 4.222DRD3, RTN4R
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912RTN4R, DISC1
alpha-amino acid metabolic process (GO:1901605) 4.52DAO, MTHFR
regulation of sodium ion transport (GO:0002028) 5.42DRD3, AKT1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562DRD3, AKT1
cellular response to external stimulus (GO:0071496) 4.22COMT, AKT1
cell proliferation (GO:0008283) 3.232DISC1, AKT1
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442DTNBP1, AKT1
regulation of excretion (GO:0044062) 6.362DRD3, COMT
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 4.322DISC1, AKT1
regulation of stress-activated MAPK cascade (GO:0032872) 4.452DTNBP1, AKT1
negative regulation of cell differentiation (GO:0045596) 3.332DRD3, RTN4R
microtubule-based process (GO:0007017) 3.542DTNBP1, DISC1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562DRD3, AKT1
regulation of cyclic nucleotide metabolic process (GO:0030799) 4.692DRD3, MC4R
positive regulation of lipid biosynthetic process (GO:0046889) 5.552HTR2A, AKT1
memory (GO:0007613) 5.132COMT, HTR2A
regulation of fat cell differentiation (GO:0045598) 5.042HTR2A, AKT1
negative regulation of developmental process (GO:0051093) 3.172DRD3, RTN4R
negative regulation of cellular protein metabolic process (GO:0032269) 2.882RTN4R, AKT1
aging (GO:0007568) 4.162HTR2A, AKT1
regulation of nucleotide biosynthetic process (GO:0030808) 4.792DRD3, MC4R
organic acid metabolic process (GO:0006082) 3.012DAO, MTHFR
positive regulation of developmental process (GO:0051094) 2.772CHI3L1, DISC1
negative regulation of protein modification process (GO:0031400) 3.42RTN4R, AKT1
response to hormone (GO:0009725) 3.332MC4R, AKT1
carbohydrate derivative metabolic process (GO:1901135) 3.072CHI3L1, AKT1
positive regulation of RNA metabolic process (GO:0051254) 2.512DRD3, AKT1
regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4.852DRD3, MC4R
positive regulation of RNA biosynthetic process (GO:1902680) 2.542DRD3, AKT1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812DRD3, AKT1
protein localization to organelle (GO:0033365) 3.572DISC1, HTR2A
system development (GO:0048731) 2.922DISC1, AKT1
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562CHI3L1, HTR2A
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232CHI3L1, HTR2A
positive regulation of growth (GO:0045927) 4.252DISC1, AKT1
neuron projection morphogenesis (GO:0048812) 4.342DTNBP1, RTN4R
macromolecular complex subunit organization (GO:0043933) 2.142SETD1A, MTHFR
regulation of lipid biosynthetic process (GO:0046890) 4.872HTR2A, AKT1
protein localization to cytoskeleton (GO:0044380) 6.262DISC1, HTR2A
carboxylic acid metabolic process (GO:0019752) 3.122DAO, MTHFR
regulation of JNK cascade (GO:0046328) 4.652DTNBP1, AKT1
maternal process involved in female pregnancy (GO:0060135) 6.022APOL2, AKT1
generation of precursor metabolites and energy (GO:0006091) 4.072MC4R, AKT1
regulation of generation of precursor metabolites and energy (GO:0043467) 5.242HTR2A, AKT1
chromatin organization (GO:0006325) 3.282SETD1A, MTHFR
response to interleukin-1 (GO:0070555) 5.072CHI3L1, MTHFR
cellular amino acid metabolic process (GO:0006520) 4.222DAO, MTHFR
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392DRD3, AKT1
regulation of renal system process (GO:0098801) 6.122DRD3, COMT
cellular component morphogenesis (GO:0032989) 3.52DTNBP1, RTN4R
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052) 4.62DISC1, AKT1
cellular response to organic substance (GO:0071310) 2.782CHI3L1, AKT1
positive regulation of fat cell differentiation (GO:0045600) 5.82HTR2A, AKT1
regulation of renal sodium excretion (GO:0035813) 6.552DRD3, COMT
positive regulation of cellular protein catabolic process (GO:1903364) 4.522DISC1, AKT1
negative regulation of protein kinase activity (GO:0006469) 4.292RTN4R, AKT1
regulation of cellular protein catabolic process (GO:1903362) 4.232DISC1, AKT1
apoptotic process (GO:0006915) 3.142CHI3L1, AKT1
positive regulation of cell growth (GO:0030307) 4.732DISC1, AKT1
regulation of mitotic cell cycle (GO:0007346) 3.712DRD3, AKT1
cellular protein modification process (GO:0006464) 1.792SETD1A, AKT1
macromolecule biosynthetic process (GO:0009059) 1.612SETD1A, AKT1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472DRD3, COMT
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.852MC4R, HTR2A
regulation of protein kinase B signaling (GO:0051896) 4.922DRD3, CHI3L1
macromolecule catabolic process (GO:0009057) 3.02CHI3L1, AKT1
response to oxygen levels (GO:0070482) 4.022AKT1, MTHFR
adult behavior (GO:0030534) 4.792DRD3, HTR2A
regulation of locomotion (GO:0040012) 3.122DRD3, AKT1
carbohydrate metabolic process (GO:0005975) 3.262CHI3L1, AKT1
cell projection morphogenesis (GO:0048858) 4.052DTNBP1, RTN4R
nervous system development (GO:0007399) 3.532DISC1, AKT1
regulation of cell cycle (GO:0051726) 2.932DRD3, AKT1
single-organism organelle organization (GO:1902589) 2.682DTNBP1, DISC1
cellular macromolecule localization (GO:0070727) 3.12DISC1, HTR2A
response to peptide (GO:1901652) 3.942MC4R, AKT1
regulation of dopamine receptor signaling pathway (GO:0060159) 7.652DRD3, DTNBP1
negative regulation of protein phosphorylation (GO:0001933) 3.792RTN4R, AKT1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of oxidoreductase activity (GO:0051341) -5.270.005DAOA, SYN2, DAO, HTR2A, AKT1
catechol-containing compound metabolic process (GO:0009712) -6.020.007DRD3, DAO, COMT
catecholamine metabolic process (GO:0006584) -6.020.007DRD3, DAO, COMT
negative regulation of neurogenesis (GO:0050768) -4.220.047DISC1, DRD3, RTN4R, HTR2A, AKT1
dopamine metabolic process (GO:0042417) -6.510.002DRD3, DAO, COMT
response to morphine (GO:0043278) NEW6.290.022DRD3, HTR2A, AKT1
regulation of neurotransmitter transport (GO:0051588) -5.550.045DRD3, DTNBP1, SYN2, AKT1
regulation of amine transport (GO:0051952) -5.620.02DRD3, DTNBP1, HTR2A, AKT1
regulation of dopamine secretion (GO:0014059) -6.640.0DRD3, DTNBP1, HTR2A, AKT1
response to isoquinoline alkaloid (GO:0014072) NEW6.290.035DRD3, HTR2A, AKT1
regulation of catecholamine secretion (GO:0050433) -5.990.004DRD3, DTNBP1, HTR2A, AKT1
regulation of dopamine receptor signaling pathway (GO:0060159) -7.650.012DRD3, DTNBP1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.2816DRD3, DAO, MTHFR, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1, APOL2, DAOA
cell part (GO:0044464) 0.1116CHI3L1, DAO, COMT, MTHFR, APOL4, MC4R, RTN4R, DRD3, HTR2A, SETD1A, SYN2, AKT1, DISC1, DAOA, APOL2, DTNBP1
intracellular organelle (GO:0043229) 0.5114DRD3, DAO, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1, DAOA
membrane-bounded organelle (GO:0043227) 0.4714DRD3, DAO, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1, DAOA
intracellular membrane-bounded organelle (GO:0043231) 0.614DRD3, DAO, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1, DAOA
organelle (GO:0043226) 0.414DRD3, DAO, COMT, APOL4, MC4R, RTN4R, CHI3L1, HTR2A, SETD1A, SYN2, AKT1, DISC1, DTNBP1, DAOA
cytoplasmic part (GO:0044444) 0.8213DRD3, DAO, MTHFR, COMT, RTN4R, CHI3L1, HTR2A, SYN2, AKT1, DISC1, DAOA, APOL2, DTNBP1
membrane (GO:0016020) 0.6812DRD3, DAO, COMT, APOL4, MC4R, RTN4R, HTR2A, SYN2, AKT1, DISC1, DTNBP1, APOL2
membrane part (GO:0044425) 0.959DRD3, DISC1, COMT, APOL4, MC4R, RTN4R, HTR2A, DTNBP1, APOL2
vesicle (GO:0031982) 1.649DRD3, DISC1, COMT, RTN4R, CHI3L1, HTR2A, SYN2, AKT1, DTNBP1
cytoplasm (GO:0005737) 1.018CHI3L1, DISC1, COMT, RTN4R, HTR2A, AKT1, DTNBP1, APOL2
plasma membrane (GO:0005886) 1.398DRD3, DISC1, COMT, MC4R, RTN4R, HTR2A, AKT1, DTNBP1
integral component of membrane (GO:0016021) 1.147DRD3, COMT, RTN4R, MC4R, APOL4, HTR2A, APOL2
membrane-bounded vesicle (GO:0031988) 1.717DRD3, DISC1, COMT, RTN4R, CHI3L1, HTR2A, SYN2
intracellular organelle part (GO:0044446) 0.817DAO, SYN2, SETD1A, AKT1, DISC1, DTNBP1, APOL2
neuron part (GO:0097458) 2.647DISC1, MTHFR, COMT, RTN4R, HTR2A, SYN2, DTNBP1
organelle part (GO:0044422) 0.797DISC1, SYN2, SETD1A, AKT1, DAO, DTNBP1, APOL2
cell projection (GO:0042995) 2.477DRD3, DISC1, MTHFR, COMT, RTN4R, HTR2A, DTNBP1
intrinsic component of membrane (GO:0031224) 1.137DRD3, COMT, RTN4R, MC4R, APOL4, HTR2A, APOL2
cytosol (GO:0005829) 1.686DAO, MTHFR, COMT, HTR2A, AKT1, DTNBP1
cell projection part (GO:0044463) 2.976DISC1, COMT, RTN4R, HTR2A, AKT1, DTNBP1
plasma membrane part (GO:0044459) 1.956DRD3, DISC1, COMT, RTN4R, HTR2A, DTNBP1
neuron projection (GO:0043005) 3.126DISC1, MTHFR, COMT, RTN4R, HTR2A, DTNBP1
cytoplasmic vesicle (GO:0031410) 2.875DRD3, DTNBP1, DISC1, SYN2, HTR2A
nucleus (GO:0005634) 1.075SETD1A, DTNBP1, DISC1, MC4R, AKT1
synapse part (GO:0044456) 3.425AKT1, DTNBP1, DISC1, COMT, SYN2
intracellular vesicle (GO:0097708) 2.865DRD3, DTNBP1, DISC1, SYN2, HTR2A
protein complex (GO:0043234) 1.514SETD1A, DISC1, DTNBP1, AKT1
plasma membrane region (GO:0098590) 2.974DTNBP1, DISC1, COMT, HTR2A
macromolecular complex (GO:0032991) 1.354SETD1A, DISC1, DTNBP1, AKT1
endoplasmic reticulum (GO:0005783) 2.564RTN4R, CHI3L1, DISC1, DTNBP1
intracellular non-membrane-bounded organelle (GO:0043232) 1.764SETD1A, DISC1, DTNBP1, AKT1
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.124DRD3, DISC1, SYN2, HTR2A
cell body (GO:0044297) 3.744RTN4R, DISC1, COMT, HTR2A
mitochondrion (GO:0005739) 2.424DAOA, DISC1, COMT, AKT1
axon (GO:0030424) 4.154DTNBP1, DISC1, COMT, HTR2A
non-membrane-bounded organelle (GO:0043228) 1.764SETD1A, DISC1, DTNBP1, AKT1
extracellular region part (GO:0044421) 1.574APOL4, CHI3L1, RTN4R, COMT
cell junction (GO:0030054) 2.754DTNBP1, DISC1, SYN2, AKT1
synaptic membrane (GO:0097060) 4.223DTNBP1, DISC1, COMT
extracellular organelle (GO:0043230) 1.893CHI3L1, RTN4R, COMT
organelle membrane (GO:0031090) 1.973DTNBP1, DAO, SYN2
bounding membrane of organelle (GO:0098588) 2.393DTNBP1, DAO, SYN2
postsynaptic membrane (GO:0045211) 4.473DTNBP1, DISC1, COMT
postsynapse (GO:0098794) 4.873DTNBP1, COMT, AKT1
synapse (GO:0045202) 3.583DTNBP1, DISC1, SYN2
integral component of plasma membrane (GO:0005887) 2.573DRD3, RTN4R, HTR2A
extracellular region (GO:0005576) 2.183APOL2, CHI3L1, APOL4
perinuclear region of cytoplasm (GO:0048471) 3.353DAOA, DISC1, CHI3L1
extracellular vesicle (GO:1903561) 1.893CHI3L1, RTN4R, COMT
intrinsic component of plasma membrane (GO:0031226) 2.533DRD3, RTN4R, HTR2A
whole membrane (GO:0098805) 2.853DTNBP1, DAO, SYN2
extracellular exosome (GO:0070062) 1.893CHI3L1, RTN4R, COMT
synaptic vesicle (GO:0008021) 5.192DISC1, SYN2
site of polarized growth (GO:0030427) 4.852DTNBP1, RTN4R
growth cone (GO:0030426) 4.892DTNBP1, RTN4R
dendrite (GO:0030425) 3.922COMT, HTR2A
endoplasmic reticulum membrane (GO:0005789) 2.952DTNBP1, APOL2
exocytic vesicle (GO:0070382) 5.032DISC1, SYN2
transport vesicle (GO:0030133) 4.32DISC1, SYN2
cytoskeleton (GO:0005856) 2.552DISC1, AKT1
ciliary basal body (GO:0036064) 5.362DISC1, AKT1
extracellular space (GO:0005615) 2.632CHI3L1, APOL4
neuron spine (GO:0044309) 5.042DTNBP1, COMT
microtubule organizing center (GO:0005815) 3.422DISC1, AKT1
nucleoplasm (GO:0005654) 1.892SETD1A, AKT1
endoplasmic reticulum part (GO:0044432) 2.732DTNBP1, APOL2
cytoskeletal part (GO:0044430) 2.492DISC1, AKT1
cytoplasmic vesicle part (GO:0044433) 3.412DTNBP1, SYN2
neuronal cell body (GO:0043025) 3.92RTN4R, HTR2A
exocytic vesicle membrane (GO:0099501) 5.782DTNBP1, SYN2
catalytic complex (GO:1902494) 2.92SETD1A, DISC1
secretory vesicle (GO:0099503) 4.02DISC1, SYN2
ciliary part (GO:0044441) 4.052DISC1, AKT1
transport vesicle membrane (GO:0030658) 4.862DTNBP1, SYN2
cytoplasmic vesicle membrane (GO:0030659) 3.672DTNBP1, SYN2
postsynaptic density (GO:0014069) 4.772DTNBP1, DISC1
postsynaptic specialization (GO:0099572) 4.772DTNBP1, DISC1
vesicle membrane (GO:0012506) 3.632DTNBP1, SYN2
synaptic vesicle membrane (GO:0030672) 5.782DTNBP1, SYN2
dendritic spine (GO:0043197) 5.062DTNBP1, COMT
nuclear part (GO:0044428) 1.552SETD1A, AKT1
axon part (GO:0033267) 4.42DTNBP1, RTN4R

NET-GE enrichment

Term New enriched termICP valueGenes
dendritic shaft (GO:0043198) NEW6.160.024DRD3, HTR2A, AKT1
neuron part (GO:0097458) -2.640.015DRD3, DISC1, MTHFR, COMT, MC4R, HTR2A, SETD1A, SYN2, AKT1, DTNBP1