Disease table of MITOCHONDRIAL COMPLEX IV DEFICIENCY OMIM ID: 220110

Gene-disease associations table

GeneAssociated with MITOCHONDRIAL COMPLEX IV DEFICIENCY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MT-CO1HUMSAVARHGNC linkMT4550500, 500008, 220110, 114500
MT-CO2HUMSAVARHGNC linkMT1220110
FASTKD2OMIMHGNC link2q33.31220110
PET100OMIMHGNC link19p13.21220110
COX20OMIMHGNC link1q441220110
SCO1OMIM, HUMSAVARHGNC link17p13.11220110
TACO1OMIMHGNC link17q23.32PS601462, 220110
APOPT1OMIMHGNC link14q32.331220110
COX8AOMIMHGNC link11q13.11220110
COX10OMIM, HUMSAVARHGNC link17p123256000, 220110, PS601462
COX6B1OMIM, HUMSAVARHGNC link19q13.121220110
COX14OMIMHGNC link12q13.121220110

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17p12SCO1, COX10
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
17p2SCO1, COX10
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
173SCO1, TACO1, COX10
192COX6B1, PET100
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PET100COX14No1COX17

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MT-CO1MT-CO2Yesbinding26UQCRC2, UQCRQ, CYC1, COX6A1, COX6C, COX5A, COX4I2, COX7A2L, UQCRH, UQCRB, PMPCB, MT-CO3, COX6A2, COX7C, BCS1L, COX8A, CYCS, UQCRC1, COX5B, UQCR10, MT-CYB, NDUFA4, COX4I1, SURF1, UQCRFS1, COX6B1
MT-CO1SCO1No-1MT-CO2
MT-CO1COX8AYesbinding11COX5B, COX6C, MT-CO3, COX7C, COX5A, COX4I1, COX6A1, MT-CO2, CYCS, COX7A2L, COX6B1
MT-CO1COX10Yesbinding0
MT-CO1COX6B1Yesbinding23CYCS, UQCRQ, CYC1, UQCRB, COX6C, COX5A, COX4I2, COX6A1P2, COX7A2L, UQCRH, MT-CO3, COX6A2, COX7C, MT-CO2, COX8A, UQCRC2, UQCRC1, COX5B, UQCR10, MT-CYB, COX6A1, COX4I1, UQCRFS1
MT-CO1COX14Yesbinding0
MT-CO2SCO1Yesbinding0
MT-CO2COX8AYesbinding11MT-CO1, COX6C, MT-CO3, COX7C, COX5A, COX5B, COX6A1, COX4I1, CYCS, COX7A2L, COX6B1
MT-CO2COX10No-1MT-CO1
MT-CO2COX6B1Yesbinding22MT-CO1, CYCS, UQCRQ, CYC1, COX6A1, COX6C, COX5A, COX4I2, COX7A2L, UQCRH, UQCRB, MT-CO3, COX6A2, COX7C, COX8A, UQCRC2, UQCRC1, COX5B, UQCR10, MT-CYB, COX4I1, UQCRFS1
MT-CO2COX14No-1MT-CO1
SCO1COX8ANo-1MT-CO2
SCO1COX6B1No-1MT-CO2
COX8ACOX10No-1MT-CO1
COX8ACOX6B1Yesbinding11COX5B, COX6C, MT-CO3, COX7C, COX5A, MT-CO1, COX6A1, MT-CO2, CYCS, COX7A2L, COX4I1
COX8ACOX14No-1MT-CO1
COX10COX6B1No-1MT-CO1
COX10COX14No-1MT-CO1
COX6B1COX14No-1MT-CO1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.495MT-CO1, MT-CO2, COX8A, COX6B1, COX10
Oxidative phosphorylationhsa001905.695MT-CO1, MT-CO2, COX8A, COX6B1, COX10
Alzheimer's diseasehsa050105.344MT-CO1, MT-CO2, COX8A, COX6B1
Huntington's diseasehsa050165.174MT-CO1, MT-CO2, COX8A, COX6B1
Cardiac muscle contractionhsa042606.344MT-CO1, COX8A, MT-CO2, COX6B1
Parkinson's diseasehsa050125.594MT-CO1, MT-CO2, COX8A, COX6B1
Non-alcoholic fatty liver disease (NAFLD)hsa049325.514MT-CO1, COX8A, MT-CO2, COX6B1

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.038MT-CO1, COX8A, MT-CO2, COX6B1
Global and overview mapsNEW2.470.017MT-CO1, COX14, MT-CO2, COX8A, COX10, COX6B1
Endocrine and metabolic diseasesNEW4.750.0MT-CO1, MT-CO2, COX8A, COX6B1
MetabolismNEW2.060.014MT-CO1, MT-CO2, COX8A, COX6B1, COX10
Oxidative phosphorylation (hsa00190) -5.690.0MT-CO1, COX14, MT-CO2, COX8A, COX10, COX6B1
Cardiac muscle contraction (hsa04260) -6.340.0MT-CO1, COX8A, MT-CO2, COX6B1
Metabolic pathways (hsa01100) -2.490.016MT-CO1, COX14, MT-CO2, COX8A, COX10, COX6B1
Energy metabolismNEW5.420.0MT-CO1, COX14, MT-CO2, COX8A, COX10, COX6B1
Circulatory systemNEW4.630.008MT-CO1, MT-CO2, COX8A, COX6B1
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.0MT-CO1, MT-CO2, COX8A, COX6B1
Huntington's disease (hsa05016) -5.170.0MT-CO1, MT-CO2, COX8A, COX6B1
Alzheimer's disease (hsa05010) -5.340.0MT-CO1, COX8A, MT-CO2, COX6B1
Parkinson's disease (hsa05012) -5.590.0MT-CO1, COX8A, MT-CO2, COX6B1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.349MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1, COX10
Transcriptional Regulation by TP53R-HSA-37009896.738MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Respiratory electron transportR-HSA-6111056.448MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.128MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Generic Transcription PathwayR-HSA-2124363.868MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.718MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Gene ExpressionR-HSA-741602.728MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1
TP53 Regulates Metabolic GenesR-HSA-56288976.738MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1

NET-GE enrichment

Term New enriched termICP valueGenes
Transcriptional Regulation by TP53 (R-HSA-3700989) -6.730.0MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Respiratory electron transport (R-HSA-611105) -6.440.0MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Generic Transcription Pathway (R-HSA-212436) -3.860.0MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0MT-CO1, COX14, TACO1, MT-CO2, SCO1, COX20, COX8A, COX6B1
Metabolism (R-HSA-1430728) -2.340.0MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1, COX10
Gene Expression (R-HSA-74160) -2.720.0MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1
TP53 Regulates Metabolic Genes (R-HSA-5628897) -6.730.0MT-CO1, COX14, TACO1, COX8A, SCO1, COX20, MT-CO2, COX6B1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.056MT-CO1, FASTKD2, MT-CO2, COX8A, COX10, COX6B1
cytochrome-c oxidase activity (GO:0004129) 6.345COX6B1, MT-CO1, COX8A, MT-CO2, COX10
substrate-specific transmembrane transporter activity (GO:0022891) 2.95MT-CO1, MT-CO2, COX8A, COX6B1, COX10
substrate-specific transporter activity (GO:0022892) 2.725MT-CO1, MT-CO2, COX8A, COX6B1, COX10
inorganic cation transmembrane transporter activity (GO:0022890) 3.495COX6B1, MT-CO1, COX8A, MT-CO2, COX10
transporter activity (GO:0005215) 2.575COX6B1, MT-CO1, COX8A, MT-CO2, COX10
cation transmembrane transporter activity (GO:0008324) 3.325COX6B1, MT-CO1, COX8A, MT-CO2, COX10
transmembrane transporter activity (GO:0022857) 2.825COX6B1, MT-CO1, COX8A, MT-CO2, COX10
ion transmembrane transporter activity (GO:0015075) 3.045MT-CO1, MT-CO2, COX8A, COX6B1, COX10
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.875MT-CO1, MT-CO2, COX8A, COX6B1, COX10
oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor (GO:0016676) 6.345MT-CO1, MT-CO2, COX8A, COX6B1, COX10
binding (GO:0005488) 0.185FASTKD2, MT-CO1, COX8A, MT-CO2, SCO1
oxidoreductase activity, acting on a heme group of donors (GO:0016675) 6.35MT-CO1, MT-CO2, COX8A, COX6B1, COX10
electron carrier activity (GO:0009055) 4.975COX6B1, MT-CO1, COX8A, MT-CO2, COX10
hydrogen ion transmembrane transporter activity (GO:0015078) 5.015COX6B1, MT-CO1, COX8A, MT-CO2, COX10
heme-copper terminal oxidase activity (GO:0015002) 6.345COX6B1, MT-CO1, COX8A, MT-CO2, COX10
oxidoreductase activity (GO:0016491) 3.125COX6B1, MT-CO1, COX8A, MT-CO2, COX10
protein binding (GO:0005515) 0.464MT-CO1, COX8A, MT-CO2, SCO1
cation binding (GO:0043169) 1.43MT-CO1, MT-CO2, SCO1
metal ion binding (GO:0046872) 1.413MT-CO1, MT-CO2, SCO1
transition metal ion binding (GO:0046914) 2.483MT-CO1, MT-CO2, SCO1
ion binding (GO:0043167) 1.363MT-CO1, MT-CO2, SCO1
organic cyclic compound binding (GO:0097159) 1.052MT-CO1, FASTKD2
transferase activity (GO:0016740) 1.952FASTKD2, COX10
copper ion binding (GO:0005507) 5.712MT-CO2, SCO1
heterocyclic compound binding (GO:1901363) 1.062MT-CO1, FASTKD2

NET-GE enrichment

Term New enriched termICP valueGenes
cytochrome-c oxidase activity (GO:0004129) -6.340.0MT-CO2, COX8A, COX6B1
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.033MT-CO2, COX8A, COX6B1
monovalent inorganic cation transmembrane transporter activity (GO:0015077) -3.870.017MT-CO1, COX8A, MT-CO2, COX6B1
oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor (GO:0016676) -6.340.0MT-CO2, COX8A, COX6B1
oxidoreductase activity, acting on a heme group of donors (GO:0016675) -6.30.0MT-CO2, COX8A, COX6B1
copper ion binding (GO:0005507) -5.710.009MT-CO2, SCO1
hydrogen ion transmembrane transporter activity (GO:0015078) -5.010.0MT-CO1, COX8A, MT-CO2, COX6B1
heme-copper terminal oxidase activity (GO:0015002) -6.340.0MT-CO2, COX8A, COX6B1
electron carrier activity (GO:0009055) -4.970.008MT-CO2, COX8A, COX6B1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2611MT-CO1, COX14, FASTKD2, PET100, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
single-organism cellular process (GO:0044763) 0.659MT-CO1, FASTKD2, APOPT1, SCO1, COX20, MT-CO2, COX8A, COX6B1, COX10
single-organism process (GO:0044699) 0.489MT-CO1, FASTKD2, APOPT1, SCO1, COX20, COX8A, COX6B1, MT-CO2, COX10
generation of precursor metabolites and energy (GO:0006091) 4.078MT-CO1, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
cellular metabolic process (GO:0044237) 0.698MT-CO1, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
metabolic process (GO:0008152) 0.588MT-CO1, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
cellular component organization or biogenesis (GO:0071840) 1.227PET100, COX14, FASTKD2, SCO1, COX20, COX8A, COX10
single-organism metabolic process (GO:0044710) 1.637MT-CO1, FASTKD2, MT-CO2, COX20, COX8A, COX6B1, COX10
cellular component organization (GO:0016043) 1.247PET100, COX14, FASTKD2, SCO1, COX20, COX8A, COX10
oxidation-reduction process (GO:0055114) 2.917MT-CO1, FASTKD2, MT-CO2, COX20, COX8A, COX6B1, COX10
cellular component assembly (GO:0022607) 2.146PET100, COX14, FASTKD2, SCO1, COX20, COX10
macromolecular complex subunit organization (GO:0043933) 2.146PET100, COX14, FASTKD2, SCO1, COX20, COX10
cation transport (GO:0006812) 3.116MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
ion transport (GO:0006811) 2.666MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
transport (GO:0006810) 1.516MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
macromolecular complex assembly (GO:0065003) 2.556PET100, COX14, FASTKD2, SCO1, COX20, COX10
cellular macromolecular complex assembly (GO:0034622) 3.186PET100, COX14, FASTKD2, SCO1, COX20, COX10
establishment of localization (GO:0051234) 1.486MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
localization (GO:0051179) 1.46MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
hydrogen transport (GO:0006818) 4.725COX6B1, MT-CO1, COX8A, MT-CO2, COX10
proton transport (GO:0015992) 4.735COX6B1, MT-CO1, COX8A, MT-CO2, COX10
protein complex subunit organization (GO:0071822) 2.65COX20, SCO1, PET100, COX14, COX10
transmembrane transport (GO:0055085) 2.725COX6B1, MT-CO1, COX8A, MT-CO2, COX10
hydrogen ion transmembrane transport (GO:1902600) 4.975MT-CO1, MT-CO2, COX8A, COX6B1, COX10
inorganic ion transmembrane transport (GO:0098660) 3.385COX6B1, MT-CO1, COX8A, MT-CO2, COX10
mitochondrial electron transport, cytochrome c to oxygen (GO:0006123) 6.735COX6B1, MT-CO1, COX8A, MT-CO2, COX10
cytochrome complex assembly (GO:0017004) 6.45COX20, PET100, COX14, COX10, SCO1
respiratory chain complex IV assembly (GO:0008535) 6.735COX20, PET100, COX14, COX10, SCO1
ion transmembrane transport (GO:0034220) 3.085COX6B1, MT-CO1, COX8A, MT-CO2, COX10
single-organism transport (GO:0044765) 2.185MT-CO1, MT-CO2, COX8A, COX6B1, COX10
electron transport chain (GO:0022900) 5.095MT-CO1, MT-CO2, COX8A, COX6B1, COX10
biological regulation (GO:0065007) 0.395TACO1, APOPT1, COX8A, MT-CO2, SCO1
inorganic cation transmembrane transport (GO:0098662) 3.555MT-CO1, MT-CO2, COX8A, COX6B1, COX10
respiratory electron transport chain (GO:0022904) 5.115COX6B1, MT-CO1, COX8A, MT-CO2, COX10
single-organism localization (GO:1902578) 2.095MT-CO1, MT-CO2, COX8A, COX6B1, COX10
cation transmembrane transport (GO:0098655) 3.435COX6B1, MT-CO1, COX8A, MT-CO2, COX10
cellular protein complex assembly (GO:0043623) 3.95COX20, PET100, COX14, COX10, SCO1
monovalent inorganic cation transport (GO:0015672) 3.745COX6B1, MT-CO1, COX8A, MT-CO2, COX10
protein complex assembly (GO:0006461) 2.785COX20, SCO1, PET100, COX14, COX10
cellular component biogenesis (GO:0044085) 4.464COX20, FASTKD2, PET100, COX14
cellular respiration (GO:0045333) 5.94COX20, FASTKD2, MT-CO1, COX10
energy derivation by oxidation of organic compounds (GO:0015980) 4.934COX20, FASTKD2, MT-CO1, COX10
mitochondrial respiratory chain complex assembly (GO:0033108) 5.313COX20, PET100, COX14
mitochondrial respiratory chain complex IV assembly (GO:0033617) 7.333COX20, PET100, COX14
protein complex biogenesis (GO:0070271) 5.373COX20, PET100, COX14
regulation of cellular process (GO:0050794) 0.53APOPT1, TACO1, COX8A
organic substance metabolic process (GO:0071704) 0.633MT-CO1, FASTKD2, COX10
aerobic respiration (GO:0009060) 6.43COX20, MT-CO1, COX10
mitochondrial respiratory chain complex IV biogenesis (GO:0097034) 7.333COX20, PET100, COX14
regulation of biological process (GO:0050789) 0.453APOPT1, TACO1, COX8A
regulation of primary metabolic process (GO:0080090) 1.082APOPT1, TACO1
regulation of metabolic process (GO:0019222) 1.022APOPT1, TACO1
phosphorylation (GO:0016310) 2.632MT-CO1, FASTKD2
regulation of response to stimulus (GO:0048583) 1.542APOPT1, COX8A
cellular nitrogen compound metabolic process (GO:0034641) 1.222MT-CO1, COX10
nitrogen compound metabolic process (GO:0006807) 1.132MT-CO1, COX10
mitochondrion organization (GO:0007005) 3.692COX8A, COX10
regulation of protein metabolic process (GO:0051246) 1.932APOPT1, TACO1
organic cyclic compound metabolic process (GO:1901360) 1.262MT-CO1, COX10
regulation of biological quality (GO:0065008) 1.682MT-CO2, SCO1
developmental process (GO:0032502) 1.362MT-CO1, COX6B1
response to abiotic stimulus (GO:0009628) 2.82MT-CO1, MT-CO2
regulation of macromolecule metabolic process (GO:0060255) 1.082APOPT1, TACO1
regulation of cellular metabolic process (GO:0031323) 1.072APOPT1, TACO1
cellular aromatic compound metabolic process (GO:0006725) 1.32MT-CO1, COX10
single-organism developmental process (GO:0044767) 1.492MT-CO1, COX6B1
response to stress (GO:0006950) 1.82MT-CO1, MT-CO2
heterocycle metabolic process (GO:0046483) 1.312MT-CO1, COX10
organelle organization (GO:0006996) 2.022COX8A, COX10
primary metabolic process (GO:0044238) 0.692MT-CO1, FASTKD2
regulation of cellular protein metabolic process (GO:0032268) 1.992APOPT1, TACO1
organonitrogen compound metabolic process (GO:1901564) 2.322MT-CO1, COX10
response to stimulus (GO:0050896) 1.222MT-CO1, MT-CO2
anatomical structure development (GO:0048856) 1.582MT-CO1, COX6B1
phosphate-containing compound metabolic process (GO:0006796) 2.162MT-CO1, FASTKD2
phosphorus metabolic process (GO:0006793) 2.152MT-CO1, FASTKD2

NET-GE enrichment

Term New enriched termICP valueGenes
hydrogen ion transmembrane transport (GO:1902600) -4.970.0MT-CO1, MT-CO2, COX8A, COX6B1, COX10
cytochrome complex assembly (GO:0017004) -6.40.0SCO1, MT-CO1, COX14, MT-CO2, COX10
aerobic respiration (GO:0009060) -6.40.012MT-CO1, COX10
generation of precursor metabolites and energy (GO:0006091) -4.070.0MT-CO1, COX14, FASTKD2, MT-CO2, SCO1, COX8A, COX6B1, COX10
proton transport (GO:0015992) -4.730.0MT-CO1, MT-CO2, COX8A, COX6B1, COX10
electron transport chain (GO:0022900) -5.090.0COX6B1, MT-CO1, COX8A, MT-CO2, COX10
inorganic cation transmembrane transport (GO:0098662) -3.550.001MT-CO1, MT-CO2, COX8A, COX6B1, COX10
inorganic ion transmembrane transport (GO:0098660) -3.380.001MT-CO1, MT-CO2, COX8A, COX6B1, COX10
monovalent inorganic cation transport (GO:0015672) -3.740.0COX6B1, MT-CO1, COX8A, MT-CO2, COX10
hydrogen transport (GO:0006818) -4.720.0COX6B1, MT-CO1, COX8A, MT-CO2, COX10
cation transport (GO:0006812) -3.110.006MT-CO1, COX14, MT-CO2, SCO1, COX8A, COX10, COX6B1
ion transport (GO:0006811) -2.660.004MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
respiratory electron transport chain (GO:0022904) -5.110.0MT-CO1, MT-CO2, COX8A, COX6B1, COX10
ion transmembrane transport (GO:0034220) -3.080.006COX6B1, MT-CO1, COX8A, MT-CO2, COX10
cellular respiration (GO:0045333) -5.90.002MT-CO1, FASTKD2, COX10
cellular protein complex assembly (GO:0043623) -3.90.01SCO1, MT-CO1, COX14, MT-CO2, COX10
transmembrane transport (GO:0055085) -2.720.048MT-CO1, MT-CO2, COX8A, COX6B1, COX10
oxidation-reduction process (GO:0055114) -2.910.001MT-CO1, FASTKD2, MT-CO2, COX8A, COX10, COX6B1
energy derivation by oxidation of organic compounds (GO:0015980) -4.930.048FASTKD2, MT-CO1, MT-CO2, COX10
mitochondrial electron transport, cytochrome c to oxygen (GO:0006123) -6.730.0MT-CO1, MT-CO2, COX10
respiratory chain complex IV assembly (GO:0008535) -6.730.0SCO1, MT-CO1, COX14, MT-CO2, COX10
cation transmembrane transport (GO:0098655) -3.430.001MT-CO1, MT-CO2, COX8A, COX6B1, COX10
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.612MT-CO1, COX14, FASTKD2, TACO1, PET100, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
cell part (GO:0044464) 0.1112MT-CO1, COX14, FASTKD2, TACO1, APOPT1, SCO1, COX20, COX8A, PET100, COX6B1, MT-CO2, COX10
cytoplasmic part (GO:0044444) 0.8212MT-CO1, COX14, FASTKD2, TACO1, PET100, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
mitochondrion (GO:0005739) 2.4212MT-CO1, COX14, FASTKD2, TACO1, PET100, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
intracellular organelle (GO:0043229) 0.5112PET100, COX14, FASTKD2, TACO1, MT-CO1, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
intracellular part (GO:0044424) 0.2812MT-CO1, COX14, FASTKD2, TACO1, PET100, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
membrane-bounded organelle (GO:0043227) 0.4712PET100, COX14, FASTKD2, TACO1, MT-CO1, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
organelle (GO:0043226) 0.412PET100, COX14, FASTKD2, TACO1, MT-CO1, SCO1, COX20, MT-CO2, COX8A, COX6B1, APOPT1, COX10
intracellular organelle part (GO:0044446) 0.819MT-CO1, COX14, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
membrane (GO:0016020) 0.689MT-CO1, COX14, PET100, SCO1, COX20, COX8A, COX6B1, MT-CO2, COX10
mitochondrial part (GO:0044429) 2.929MT-CO1, COX14, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
organelle part (GO:0044422) 0.799MT-CO1, COX14, FASTKD2, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
organelle membrane (GO:0031090) 1.978MT-CO1, COX14, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
mitochondrial membrane (GO:0031966) 3.318MT-CO1, COX14, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
membrane part (GO:0044425) 0.957MT-CO1, COX14, PET100, COX20, COX8A, MT-CO2, COX10
integral component of membrane (GO:0016021) 1.147MT-CO1, COX14, PET100, COX20, COX8A, MT-CO2, COX10
intrinsic component of membrane (GO:0031224) 1.137MT-CO1, COX14, PET100, COX20, COX8A, MT-CO2, COX10
mitochondrial inner membrane (GO:0005743) 3.656MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
organelle inner membrane (GO:0019866) 3.566MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
macromolecular complex (GO:0032991) 1.355FASTKD2, MT-CO1, COX8A, MT-CO2, COX10
protein complex (GO:0043234) 1.514MT-CO1, COX8A, MT-CO2, COX10
cytochrome complex (GO:0070069) 6.514MT-CO1, COX8A, MT-CO2, COX10
membrane protein complex (GO:0098796) 2.843MT-CO1, COX8A, MT-CO2
respiratory chain complex (GO:0098803) 5.473MT-CO1, COX8A, MT-CO2
respiratory chain complex IV (GO:0045277) 7.093MT-CO1, COX8A, MT-CO2
mitochondrial respiratory chain complex IV (GO:0005751) 7.42MT-CO1, COX8A
intracellular non-membrane-bounded organelle (GO:0043232) 1.762FASTKD2, SCO1
inner mitochondrial membrane protein complex (GO:0098800) 5.012MT-CO1, COX8A
mitochondrial membrane part (GO:0044455) 4.542MT-CO1, COX8A
non-membrane-bounded organelle (GO:0043228) 1.762FASTKD2, SCO1
respiratory chain (GO:0070469) 5.512MT-CO1, MT-CO2
mitochondrial protein complex (GO:0098798) 4.782MT-CO1, COX8A

NET-GE enrichment

Term New enriched termICP valueGenes
respiratory chain complex IV (GO:0045277) -7.090.001MT-CO1, MT-CO2
organelle envelope lumen (GO:0031970) NEW5.410.008MT-CO2, SCO1, COX6B1
organelle inner membrane (GO:0019866) -3.560.0MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
cytochrome complex (GO:0070069) -6.510.002MT-CO1, MT-CO2
mitochondrial membrane (GO:0031966) -3.310.0MT-CO1, COX14, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
mitochondrial inner membrane (GO:0005743) -3.650.0MT-CO1, MT-CO2, SCO1, COX8A, COX10, COX6B1
cytoplasmic part (GO:0044444) -0.820.001MT-CO1, COX14, FASTKD2, TACO1, APOPT1, SCO1, COX20, COX8A, PET100, COX6B1, MT-CO2, COX10
mitochondrion (GO:0005739) -2.420.0MT-CO1, COX14, FASTKD2, TACO1, APOPT1, SCO1, COX20, MT-CO2, PET100, COX6B1, COX10
mitochondrial part (GO:0044429) -2.920.0MT-CO1, COX14, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10
organelle membrane (GO:0031090) -1.970.001MT-CO1, COX14, MT-CO2, SCO1, COX20, COX8A, COX6B1, COX10