| Gene | Associated with MYOGLOBINURIA, RECURRENT in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
|---|---|---|---|---|---|
| MT-CYB | OMIM | HGNC link | MT | 4 | 550500, 500000, 520100, 535000 |
| MT-CO1 | OMIM | HGNC link | MT | 4 | 550500, 500008, 220110, 114500 |
| MT-CO3 | OMIM | HGNC link | MT | 4 | 540000, 550500, 535000, 256000 |
Download the disease annotation in CSV format
| Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
|---|---|---|---|---|---|
| MT-CYB | MT-CO1 | Yes | activation, binding | 23 | CYCS, UQCRQ, CYC1, UQCRB, BCS1L, COX6C, COX5A, COX4I2, UQCRH, PMPCB, MT-CO3, COX6A2, COX7C, MT-CO2, UQCRC2, UQCRC1, COX5B, UQCR10, NDUFA4, COX6A1, COX6B1, COX4I1, UQCRFS1 |
| MT-CYB | MT-CO3 | Yes | activation, binding | 22 | MT-CO1, CYCS, UQCRQ, CYC1, COX6A1, BCS1L, COX6C, COX5A, COX4I2, UQCRC1, UQCRB, COX6A2, COX7C, MT-CO2, UQCRC2, UQCRH, COX5B, UQCR10, NDUFA4, COX4I1, COX6B1, UQCRFS1 |
| MT-CO1 | MT-CO3 | Yes | binding | 28 | UQCRC2, UQCRQ, CYC1, COX6A1, BCS1L, COX6C, COX5A, MT-ATP6, COX4I2, COX6A1P2, COX7A2L, UQCRH, UQCRB, COX6B2, COA6, COX6A2, COX7C, MT-CO2, CYCS, UQCRC1, COX5B, UQCR10, MT-CYB, NDUFA4, COX8A, UQCRFS1, COX4I1, COX6B1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
| Gene1 | Gene2 | Direct interaction | More information |
|---|---|---|---|
| MT-CO1 | MT-CO3 | yes, complex | Subunits MT-CO 1-3 form the functional core of the enzyme complex; component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex. [Uniprot] |
| MT-CO1 | MT-CYB | yes, maybe indirect | Subunits MT-CO 1-3 form the functional core of the enzyme complex; component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex. [Uniprot] |
| MT-CO3 | MT-CYB | yes, maybe indirect | Subunits MT-CO 1-3 form the functional core of the enzyme complex; component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex. [Uniprot] |
| KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
|---|---|---|---|---|
| Oxidative phosphorylation | hsa00190 | 5.69 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Cardiac muscle contraction | hsa04260 | 6.34 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Metabolic pathways | hsa01100 | 2.49 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Parkinson's disease | hsa05012 | 5.59 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Huntington's disease | hsa05016 | 5.17 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Alzheimer's disease | hsa05010 | 5.34 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| Neurodegenerative diseases | NEW | 4.27 | 0.002 | MT-CO1, MT-CO3, MT-CYB |
| Endocrine and metabolic diseases | NEW | 4.75 | 0.001 | MT-CO1, MT-CO3, MT-CYB |
| Oxidative phosphorylation (hsa00190) | - | 5.69 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| Alzheimer's disease (hsa05010) | - | 5.34 | 0.001 | MT-CO1, MT-CO3, MT-CYB |
| Energy metabolism | NEW | 5.42 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| Circulatory system | NEW | 4.63 | 0.001 | MT-CO1, MT-CO3, MT-CYB |
| Non-alcoholic fatty liver disease (NAFLD) (hsa04932) | - | 5.51 | 0.001 | MT-CO1, MT-CO3, MT-CYB |
| Huntington's disease (hsa05016) | - | 5.17 | 0.001 | MT-CO1, MT-CO3, MT-CYB |
| Cardiac muscle contraction (hsa04260) | - | 6.34 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| Parkinson's disease (hsa05012) | - | 5.59 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
|---|---|---|---|---|
| Metabolism | R-HSA-1430728 | 2.34 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Respiratory electron transport | R-HSA-611105 | 6.44 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | R-HSA-163200 | 6.12 | 3 | MT-CO1, MT-CO3, MT-CYB |
| The citric acid (TCA) cycle and respiratory electron transport | R-HSA-1428517 | 5.71 | 3 | MT-CO1, MT-CO3, MT-CYB |
| Generic Transcription Pathway | R-HSA-212436 | 3.86 | 2 | MT-CO1, MT-CO3 |
| Transcriptional Regulation by TP53 | R-HSA-3700989 | 6.73 | 2 | MT-CO1, MT-CO3 |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | 6.73 | 2 | MT-CO1, MT-CO3 |
| Gene Expression | R-HSA-74160 | 2.72 | 2 | MT-CO1, MT-CO3 |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| inorganic cation transmembrane transporter activity (GO:0022890) | - | 3.49 | 0.014 | MT-CO1, MT-CO3, MT-CYB |
| heme binding (GO:0020037) | NEW | 4.86 | 0.048 | MT-CO1, MT-CYB |
| cation transmembrane transporter activity (GO:0008324) | - | 3.32 | 0.028 | MT-CO1, MT-CO3, MT-CYB |
| monovalent inorganic cation transmembrane transporter activity (GO:0015077) | - | 3.87 | 0.004 | MT-CO1, MT-CO3, MT-CYB |
| hydrogen ion transmembrane transporter activity (GO:0015078) | - | 5.01 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| electron carrier activity (GO:0009055) | - | 4.97 | 0.003 | MT-CO3, MT-CYB |
| Term | New enriched term | IC | P value | Genes |
|---|---|---|---|---|
| mitochondrial membrane part (GO:0044455) | - | 4.54 | 0.007 | MT-CO1, MT-CO3, MT-CYB |
| respiratory chain complex IV (GO:0045277) | - | 7.09 | 0.0 | MT-CO1, MT-CO3 |
| organelle inner membrane (GO:0019866) | - | 3.56 | 0.002 | MT-CO1, MT-CO3, MT-CYB |
| cytochrome complex (GO:0070069) | - | 6.51 | 0.0 | MT-CO1, MT-CO3, MT-CYB |
| mitochondrial membrane (GO:0031966) | - | 3.31 | 0.007 | MT-CO1, MT-CO3, MT-CYB |
| mitochondrial part (GO:0044429) | - | 2.92 | 0.003 | MT-CO1, MT-CO3, MT-CYB |
| mitochondrial inner membrane (GO:0005743) | - | 3.65 | 0.0 | MT-CO1, MT-CO3, MT-CYB |