Disease table of COLORECTAL CANCER OMIM ID: 114500

Gene-disease associations table

Gene	Associated with COLORECTAL CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MT-CO1	HUMSAVAR	HGNC link	MT	4	550500, 500008, 220110, 114500
BUB1B	OMIM	HGNC link	15q15.1	3	PS257300, 176430, 114500
MLH3	OMIM	HGNC link	14q24.3	3	114500, 608089, PS120435
BAX	OMIM	HGNC link	19q13.33	2	114500, 613065
PDGFRL	OMIM, HUMSAVAR	HGNC link	8p22	2	114550, 114500
CTNNB1	OMIM, HUMSAVAR	HGNC link	3p22.1	6	114550, 155255, 167000, PS156200, 114500, 132600
AKT1	OMIM	HGNC link	14q32.33	6	167000, 176920, 114480, 181500, 114500, PS158350
ODC1	OMIM	HGNC link	2p25.1	1	114500
AXIN2	OMIM	HGNC link	17q24.1	2	114500, 608615
RAD54B	OMIM	HGNC link	8q22.1	2	114500, 605027
PIK3CA	OMIM, HUMSAVAR	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
NRAS	OMIM	HGNC link	1p13.2	8	137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
DCC	OMIM	HGNC link	18q21.2	3	133239, PS157600, 114500
AURKA	OMIM	HGNC link	20q13.2	1	114500
DLC1	OMIM	HGNC link	8p22	1	114500
FLCN	OMIM	HGNC link	17p11.2	4	135150, 144700, 173600, 114500
TRIM28	ClinVar	HGNC link	19q13.43	1	114500
PLA2G2A	OMIM	HGNC link	1p36.13	1	114500
EP300	OMIM	HGNC link	22q13.2	2	114500, PS180849
FGFR3	OMIM	HGNC link	4p16.3	16	603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482
TP53	ClinVar, OMIM	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
CCND1	OMIM	HGNC link	11q13.3	3	193300, 254500, 114500
PTPN12	OMIM	HGNC link	7q11.23	1	114500
MCC	OMIM	HGNC link	5q22.2	1	114500
KAT5	ClinVar	HGNC link	11q13.1	1	114500
TLR2	OMIM	HGNC link	4q31.3	3	114500, 607948, 246300
BRAF	OMIM, HUMSAVAR	HGNC link	7q34	8	605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
TLR4	OMIM	HGNC link	9q33.1	2	114500, PS603075
APC	ClinVar, OMIM	HGNC link	5q22.2	6	114550, PS175100, 155255, 135290, 114500, 613659
PTPRJ	OMIM	HGNC link	11p11.2	1	114500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
5q22.2	2	MCC, APC
8p22	2	DLC1, PDGFRL

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
8p22	2	DLC1, PDGFRL
5q22	2	MCC, APC
19q13	2	BAX, TRIM28
11q13	2	CCND1, KAT5

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
19q1	2	BAX, TRIM28
17p1	2	FLCN, TP53
8p2	2	DLC1, PDGFRL
5q2	2	MCC, APC
11q1	2	CCND1, KAT5

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	2	NRAS, PLA2G2A
14q	2	MLH3, AKT1
5q	2	MCC, APC
19q	2	BAX, TRIM28
11q	2	CCND1, KAT5
7q	2	PTPN12, BRAF
8p	2	DLC1, PDGFRL
17p	2	FLCN, TP53

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	CCND1, PTPRJ, KAT5
14	2	MLH3, AKT1
17	3	FLCN, TP53, AXIN2
19	2	BAX, TRIM28
1	2	NRAS, PLA2G2A
3	2	CTNNB1, PIK3CA
5	2	MCC, APC
4	2	TLR2, FGFR3
7	2	PTPN12, BRAF
8	3	DLC1, RAD54B, PDGFRL

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
CTNNB1	YES	20	PTGS2, BIRC5, PPARD, CHGA, TCF7, CLDN2, CCND1, GLCE, CD44, GLI2, NRCAM, RB1, MMP14, JUN, SPP1, VIM, MYC, PLD1, MMP7, STARD7	1	CCND1
TRIM28	YES	2	E2F3, E2F4	0
EP300	YES	56	ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD51	1	CCND1
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	5	TP53, CCND1, BAX, AKT1, CTNNB1
KAT5	YES	4	ERCC1, IL2, HDC, GMPS	0
APC	YES	11	PTGS2, NOS2, KLF4, BIRC5, SPP1, DNMT1, AKT1, MYC, AMHR2, ODC1, SGK1	2	ODC1, AKT1
CDX2	NO	28	UGT2B15, GUCY2C, DSC2, IGFBP3, MUC17, TFF3, PTGS2, HEPH, ABCB1, SLC15A1, KLF4, ELMO3, SLC9A2, MEP1A, CDH17, UGT2B17, CDKN1A, VDR, MUC2, UGT1A8, AXIN2, LCT, FUT2, UGT1A10, REG4, ACAT2, APC, CFTR	2	APC, AXIN2
KLF4	NO	30	ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH5	3	CCND1, ODC1, TP53
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	4	CCND1, EP300, ODC1, TP53
BRCA1	NO	52	ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A	2	CCND1, EP300
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	5	FGFR3, CCND1, BAX, ODC1, TLR2
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	2	FGFR3, CCND1
SP4	NO	9	BIRC5, KDR, PDE6B, CCND1, ASS1, FGFR3, ERBB2, MAOB, YY1	2	FGFR3, CCND1
HIF1A	NO	80	RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A	3	CCND1, BAX, TLR2
MYCN	NO	44	MCM8, MCM7, HDAC2, TP53, BIRC5, IFNG, HLA-F, MCM3, LRRN3, BMI1, SKP2, MDM2, ABCB1, MCM2, DDB1, NES, CD44, HLA-C, HLA-G, CDKN1A, TP53INP1, HLA-B, NGFR, HLA-A, CIITA, MCM6, CTSD, ABCC1, LXN, DKK3, BAX, CDK6, HLA-E, NDRG1, TH, EFNB3, ID2, MCM5, MCM10, MYCL, TERT, NTRK1, MCM4, CDKN1B	2	BAX, TP53
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	3	CCND1, EP300, TP53
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	CCND1, TP53
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	3	CCND1, TP53, CTNNB1
FOS	NO	56	BATF3, BCL2L1, NPPA, FIGF, ACTA1, FGFBP1, DDIT3, CYP1A2, SMAD4, SLC10A2, MMP9, CCK, PGR, LRIG2, NQO1, FOS, EZR, MMP7, PTGS2, NGF, FAS, FMO4, SMAD7, STAR, CLU, SOX7, PLAU, SRR, NOS2, SPI1, PDHA1, MFI2, MMP1, TP53, OXTR, NPY, GSTP1, NTS, NFKB1, PCK2, CXCL8, CD40LG, CREM, PLAUR, IL1A, ERCC4, MMP3, NTF3, CASP9, CSTA, HSPH1, MYC, CCND1, SPRR3, NEFL, FOXA1	2	CCND1, TP53
NUPR1	NO	5	MSL1, BCL2L1, EP300, CDKN1A, TP53	2	EP300, TP53
PAX5	NO	20	XBP1, BAX, FCER2, LEF1, BLK, BCL2, MET, CCND1, RAG2, CDKN1A, TP53, PRDM1, RB1, CD79A, PRKCE, TIMP1, FHL2, MMP1, MYCN, CD19	3	CCND1, BAX, TP53
PPARG	NO	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	CCND1, TP53
ING4	NO	14	PTGS2, CDKN1A, CXCL8, BCL2, NGF, CCND1, BAX, SPP1, CASP3, TP53, SKP2, NTRK1, CDKN1B, ANGPT1	3	CCND1, BAX, TP53
ESR1	NO	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	3	CCND1, TP53, CTNNB1
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	2	CCND1, TP53
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	APC, TP53
ATM	NO	21	PVR, SP1, CDKN1A, BAX, MCL1, FOXM1, BCL2, FAS, TERF1, IGF1R, TNFRSF10B, SLC2A1, TP53, GADD45A, KLRK1, PMAIP1, DUSP1, CFLAR, VEGFA, HIPK2, MTF1	2	BAX, TP53
ABL1	NO	10	CDKN1A, CCND2, BCL2, BCL6, BAX, TP53, JUN, PIM1, FOXO3, CSF1	2	BAX, TP53
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	3	CCND1, TP53, AKT1
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	3	FGFR3, BAX, TP53
PML	NO	18	CDKN1A, IFNB1, FLT3, TNFSF10, EP300, UBA7, PML, BAX, TP53, HCK, CASP3, HBD, CCNT1, NR4A1, EGFR, EAF2, HIPK2, CCND1	4	CCND1, EP300, BAX, TP53
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	6	BAX, PLA2G2A, TP53, AKT1, CCND1, TLR2
LEF1	NO	32	AR, OCA2, PRL, NT5E, DLL1, CD1D, NCAM1, MMP7, CCL7, CEBPA, CCND1, CHGA, TCF3, CTNNB1, ALX4, BIRC5, RAG2, CLDN2, NRCAM, SPP1, MITF, IL13, SNAI2, EDA, IL4, DSG4, IL5, ELANE, ESR1, CTLA4, MYC, MYCBP	2	CCND1, CTNNB1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	6	BAX, PLA2G2A, TP53, AKT1, CCND1, TLR2
NELFCD	NO	3	CCND1, CDKN1A, CTNNB1	2	CCND1, CTNNB1
EZH2	NO	31	PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND1	3	APC, CCND1, TP53
AATF	NO	6	CDKN1A, BBC3, BAX, TP53, BAK1, MYC	2	BAX, TP53
ERCC2	NO	5	LAMTOR5, CDKN1A, BAX, TP53, BCL2	2	BAX, TP53
VHL	NO	18	CA9, STRA13, TCF4, TFRC, ANGPT2, CXCR4, CCND1, DAB2, KLF10, CDKN1C, CA12, TP53, NMU, HIF1A, SPARC, VEGFA, IGF1R, CDKN1B	2	CCND1, TP53
SOX6	NO	6	CDKN1A, CCND1, TP53, CDK4, CTNNB1, CCNA2	3	CCND1, TP53, CTNNB1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	BAX, TP53
NR3C1	NO	36	CALD1, PNRC1, TP53, RPS6KA3, BAX, SRF, SLC10A2, SCNN1A, BGLAP, TAT, RLN2, S100P, CYP19A1, MUC4, CCND1, NR1I2, ETS1, PPIG, BRCA1, ELK1, CSF1R, CDKN1A, UGT1A1, RLN1, SPP1, BAD, NFKB1, STAT1, COX1, NR3C1, CDK4, CDK6, CCND3, ATP1B1, ATF2, MAOA	3	CCND1, BAX, TP53
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	5	NRAS, CCND1, EP300, AKT1, CTNNB1
ING1	NO	7	CDKN1A, AFP, DGCR8, BAX, TP53, CASP3, PCNA	2	BAX, TP53
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	3	CCND1, AURKA, TP53
CREBBP	NO	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	2	EP300, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
BUB1B	YES	1	ZNF143	0
BAX	YES	25	ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A	1	TP53
CTNNB1	YES	8	AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT1	1	TP53
AKT1	YES	7	APC, STAT3, GLI1, AR, TP53, RELA, NFKB1	2	APC, TP53
ODC1	YES	11	WT1, SP1, ZNF148, KLF4, CREB1, MXD1, MLX, APC, MAX, MYC, MXD4	1	APC
AXIN2	YES	2	SOX4, CDX2	0
PIK3CA	YES	1	FOXO3	0
NRAS	YES	1	AR	0
DCC	YES	1	SOX9	0
AURKA	YES	4	MED1, OTX2, E2F1, E2F3	0
DLC1	YES	1	GATA3	0
PLA2G2A	YES	2	NFKB1, RELA	0
EP300	YES	7	CREBBP, AR, NUPR1, EGR1, PML, MYC, BRCA1	0
FGFR3	YES	5	SP1, SP3, SP4, STAT1, SHOX	0
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	1	TP53
CCND1	YES	62	POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX6	3	EP300, TP53, CTNNB1
KAT5	YES	1	CLOCK	0
TLR2	YES	4	SP1, NFKB1, HIF1A, RELA	0
TLR4	YES	4	ZNF160, SPI1, IRF3, IRF8	0
APC	YES	6	YY1, USF2, CEBPZ, EZH2, CDX2, USF1	0
PTGS2	NO	41	AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF1	3	APC, EP300, CTNNB1
DNMT1	NO	6	SP1, APC, STAT3, NPM1, TP53, EP300	3	APC, EP300, TP53
ABCB1	NO	30	NFYA, EAPP, TP53, TCF7L2, SP1, TCF4, NFKB1, NR1I2, E2F1, HIPK2, SIRT1, WT1, HSF1, HDAC1, NFYC, JUN, MBD1, RELA, EP300, ETS1, NFYB, UHRF1, EGR1, PITX2, YBX1, CEBPB, ZNRD1, HIF1A, CDX2, MYCN	2	EP300, TP53
RELA	NO	18	SP1, ETV3, TNFAIP3, HSF1, BCL3, NR1H4, AR, TP53, NR1I2, HOXA9, ATF2, NFKBIA, PGR, PARP1, HDAC9, EP300, APEX1, FHL2	2	EP300, TP53
BRCA1	NO	33	WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA1	2	EP300, TP53
TBXAS1	NO	3	EP300, ETS1, TP53	2	EP300, TP53
TRIM22	NO	4	IRF1, EP300, CREBBP, TP53	2	EP300, TP53
BGLAP	NO	11	NR3C1, VDR, ATF4, ATF6, SMAD4, GTF2F1, SMAD3, TP53, EP300, MSX2, RARG	2	EP300, TP53
MDM2	NO	23	TFAP4, TP53, NFATC2, JUND, DNMT3A, SP1, ELF4, ZBTB2, SKI, MLLT10, E2F1, FOSL2, ELL, MLLT3, ETS2, EP300, ETS1, FUS, TSG101, ESR1, NR4A1, TP73, MYCN	2	EP300, TP53
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	EP300, TP53
IGFBP3	NO	12	SP1, DLX5, HOXC6, VDR, HDAC1, FLI1, MECP2, TP53, CDX2, SP3, DNMT3A, EP300	2	EP300, TP53
VEGFA	NO	53	ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F3	2	EP300, TP53
PML	NO	7	STAT2, IRF9, TP53, ARID3A, EP300, PML, STAT1	2	EP300, TP53
NFKB1	NO	30	AR, BCL3, TNFAIP3, BTF3, TP53, NFKBIA, ZNF382, HDAC9, FOS, SP1, BCL6, EGR1, NFKB1, HOXA9, TAL1, NR1I2, SRSF1, LYL1, ETV3, HSF1, RELA, PARP1, PIR, EP300, FHL2, NR1H4, NR3C1, RBPJ, APEX1, ZFP36	2	EP300, TP53
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	4	APC, EP300, TP53, CTNNB1
TP73	NO	9	KAT2B, EGR1, YY1, TP53, JUN, E2F1, EP300, MYC, SIRT1	2	EP300, TP53
SPP1	NO	23	POU2F1, ETS2, TFCP2, TBX21, POU5F1, SP1, ETV4, CEBPA, FOXD3, ETS1, CTNNB1, HTATIP2, ESRRA, APC, LEF1, VDR, HDAC1, ERG, JUN, ING4, EP300, POU2F2, NR3C1	3	APC, EP300, CTNNB1
BIRC5	NO	25	ILF3, E2F4, TP53, TCF7L2, SP1, TCF4, NFKB1, KLF4, DNMT1, CTNNB1, FOXO3, APC, LEF1, HDAC1, RELA, EP300, E2F1, STAT3, SP4, EHMT2, RB1, SP3, TP73, KLF5, MYCN	4	APC, EP300, TP53, CTNNB1
RB1	NO	19	KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX5	2	TP53, CTNNB1
GLI2	NO	3	SMAD3, TP53, CTNNB1	2	TP53, CTNNB1
CCNB2	NO	2	EP300, TP53	2	EP300, TP53
E2F3	NO	6	KLF5, TP53, BRD7, RB1, TRIM28, HIF1A	2	TRIM28, TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BUB1B	CTNNB1	No	12	KAT2B, APC, TRIM33, HDAC1, XPO1, BTRC, NEK2, CDC27, PARP1, MIS12, PLK1, CCNA2
BUB1B	AKT1	No	4	KAT2B, HSPB1, TUBB, MDM2
BUB1B	AXIN2	No	2	APC, CDC20
BUB1B	RAD54B	No	3	MDM2, SUMO1, CDC23
BUB1B	PIK3CA	No	2	HDAC1, BUB1
BUB1B	AURKA	No	17	AURKB, NUF2, MDM2, PRKCSH, PTTG1, PLK3, PSMB5, NDC80, PLK1, TUBB, BTRC, XPO1, EEF2, PSMA6, SNW1, CDC20, TP73
BUB1B	FLCN	No	1	BTRC
BUB1B	TRIM28	No	7	MDM2, UBE2C, HDAC1, CCT2, ZWINT, PARP1, MIS12
BUB1B	EP300	No	14	KAT2B, ANAPC7, ANAPC2, MDM2, AURKB, HDAC1, CDC16, BTRC, EEF2, PARP1, TP73, CDC20, SNW1, CCNA2
BUB1B	TP53	No	26	KAT2B, MDM2, BTRC, TUBB, SNW1, AURKB, CCNA2, EEF2, SUMO1, PSMD6, RAE1, HSPB1, DAXX, HDAC1, CCT2, MAD2L1BP, BAG2, PARP1, UBR5, BRCA2, PTTG1, PLK3, PLK1, ZWINT, TP73, FZR1
BUB1B	CCND1	No	6	KAT2B, HDAC1, PSMA6, BTRC, XPO1, TP73
BUB1B	PTPN12	No	2	UGP2, GANAB
BUB1B	MCC	No	1	NEK2
BUB1B	KAT5	No	5	TP73, HDAC1, MAD2L1BP, MDM2, SUMO1
BUB1B	TLR2	No	1	CD14
BUB1B	APC	Yes	9	PPP2R5A, APC, BUB1B, MAD2L1, BUB3, BTRC, XPO1, BUB1, AP2B1
MLH3	CTNNB1	No	1	AR
MLH3	AKT1	No	1	AR
MLH3	DCC	No	1	AR
MLH3	TRIM28	No	1	MYC
MLH3	EP300	No	2	MYC, AR
MLH3	TP53	No	1	MYC
MLH3	CCND1	No	1	AR
MLH3	KAT5	No	2	MYC, AR
BAX	CTNNB1	No	4	CASP3, CRYAB, HDAC6, UHRF2
BAX	AKT1	No	8	BCL2L1, LRRK2, VCP, PSMC5, HSPA4, XIAP, BAD, SNCA
BAX	PIK3CA	No	1	PCBP1
BAX	DCC	No	2	CASP3, CASP9
BAX	AURKA	No	5	HSPD1, BCL2L11, HDAC6, NIN, TP53
BAX	FLCN	No	1	BAG3
BAX	TRIM28	No	3	YWHAQ, MEPCE, TP53
BAX	EP300	No	5	PKM, YY1, XRCC6, TP53, HDAC6
BAX	FGFR3	No	1	HSPA4
BAX	TP53	Yes	21	SERPINH1, BCL2L1, BAX, CASP8, VCP, PARK7, PCBP1, YY1, HSPA4, CRYAB, TP53, MCL1, UHRF2, BAK1, BCL2, ERCC6, NIN, PSMC3, BCL2L2, PSMC5, XRCC6
BAX	CCND1	No	2	CRYAB, UHRF2
BAX	MCC	No	2	VDAC1, VCP
BAX	KAT5	No	2	HDAC6, TP53
BAX	BRAF	No	3	BAD, YWHAQ, YWHAB
BAX	TLR4	No	1	HSPA4
BAX	APC	No	1	YWHAQ
CTNNB1	AKT1	Yes	43	KAT2B, DDX5, HSP90AB1, AR, SMAD4, EZH2, CREB1, EGFR, JADE1, TRAF4, CTBP1, CHUK, IQGAP1, GSK3B, UCHL1, SMAD7, USP4, SMAD3, APP, FOXO4, BRCA1, PYGO2, SIRT1, NOTCH1, GSK3A, SFN, MAPK9, MAPK8, SMAD2, SLC9A3R1, NR4A1, AKT1, EP300, FOXO3, FANCA, HSPA8, ILK, CREBBP, IKBKB, PTEN, YWHAZ, ESR1, PHB2
CTNNB1	AXIN2	Yes	8	APC, GSK3A, SMAD7, APC2, AXIN1, NR4A1, GSK3B, FBXW11
CTNNB1	RAD54B	No	1	FUS
CTNNB1	PIK3CA	No	10	DDX5, AKT1, HDAC1, NOTCH1, SMAD2, PIK3R1, SMAD3, ESR1, NTRK1, CBL
CTNNB1	NRAS	No	1	ELAVL1
CTNNB1	DCC	No	4	CASP3, SIAH1, AR, EZR
CTNNB1	AURKA	Yes	31	DDX5, LATS2, PARK2, XPO1, CTNND1, HSP90AB1, HNRNPA1, EZR, CHUK, CEP128, GSK3B, PML, HDAC6, DHX9, DDB1, HNRNPA2B1, MAPRE1, APP, BRCA1, IKBKB, TFAP2A, HSPA8, NFKB1, AMER1, RPLP2, SKP1, FUS, AURKA, BTRC, PLK1, USP9X
CTNNB1	DLC1	No	6	CUL1, CUL4A, CAV1, DDB1, AKT1, CUL3
CTNNB1	FLCN	No	3	BTRC, FBXW11, APP
CTNNB1	TRIM28	No	30	WHSC1, HUWE1, CUL1, OBSL1, EZH2, POU5F1, COPS5, LMNA, TADA2A, SIRT1, SMURF1, SFN, HDAC1, NR4A1, RUVBL2, PARP1, NOTCH1, CDK2, UBE2D1, EMD, CREBBP, AURKA, SNRPD1, CCDC8, ILK, HIF1A, SMARCA4, NTRK1, MIS12, CUL3
CTNNB1	PLA2G2A	No	2	UCHL1, USP4
CTNNB1	EP300	Yes	61	KAT2B, AR, AKT1, BCL6, HDAC6, DDX5, SMAD4, PARP1, TCF7L2, ATF2, CREB1, PIN1, ZBTB33, ASH2L, CCNA2, PTGS2, CITED1, CARM1, TCF4, NFKB1, KLF5, SMAD7, DDB1, RBBP5, SMAD3, CHUK, FOXO3, ESR1, YWHAZ, SP1, PRKCA, LEF1, EPAS1, HDAC1, MAPK8, SMAD2, CDH1, SATB1, NR4A1, TFAP2A, RUVBL2, LRRFIP1, BCL3, EP300, BRCA1, FHL2, NOTCH1, CDK2, UBE2D1, CREBBP, BTRC, CTBP1, PIK3R1, NUP98, SIRT1, TADA3, AHR, RXRA, PPARG, MCM2, HIF1A
CTNNB1	FGFR3	No	3	HSPA8, HSPA1B, HSP90AB1
CTNNB1	TP53	No	95	DDX5, TRRAP, PIN1, HTT, RBBP5, FOXO3, KMT2A, ELAVL1, NR4A1, ABL1, UBE2B, EP400, RPLP2, HSPA1B, SKP1, SERBP1, PLK1, ESR1, KAT2B, HNRNPA1, HERC5, HSP90AB1, ASH2L, PTGS2, MAPK8, CARM1, DDB1, CCNA2, LMNA, SMURF1, SFN, HERC2, MAPK9, AURKA, HNRNPM, KLF5, HIF1A, HNRNPK, BTRC, CUL4A, ZBTB33, CHUK, IQGAP1, BCL6, TCF4, UCHL1, TUBA1A, CREB1, HNRNPA2B1, AXIN1, SMAD3, BRCA1, FBXW11, OBSL1, HDAC1, SMAD2, IKBKB, TFAP2A, PTEN, EP300, SMARCA4, MOV10, CDK2, MEN1, CCDC8, SIRT1, TADA3, HNF4A, KAT2A, FOXB1, CRYAB, ZIC3, RB1CC1, DVL2, RYK, CTBP1, MUC1, CEP128, PML, SMAD7, COPS5, TADA2A, YWHAZ, SP1, CHD8, SMARCA5, TOP2A, PARP1, GSK3B, HSPA8, CREBBP, HUWE1, NLK, UHRF2, RANBP2
CTNNB1	CCND1	No	22	KAT2B, AR, CDK2, HERC5, CUL1, XPO1, BTRC, NXF1, SP1, EP300, MCM2, BRCA1, CRYAB, HDAC1, ATF2, ELAVL1, GSK3B, HSPA8, CDK6, SKP1, UHRF2, ESR1
CTNNB1	PTPN12	No	3	NTRK1, EGFR, APP
CTNNB1	MCC	No	6	ERBB2IP, CCNA1, STRN3, NEK2, EZR, APP
CTNNB1	KAT5	No	28	AR, BCL3, HINT1, TRRAP, ZBTB33, APP, RUVBL1, NFKB1, PML, HDAC6, MAPRE1, CREB1, HDAC7, LMNA, BRCA1, SIRT1, HDAC1, NOTCH1, ATF2, RUVBL2, EP300, EP400, CREBBP, CCDC8, JADE1, ESR1, PPARG, CUL3
CTNNB1	TLR2	No	2	CREBBP, EGFR
CTNNB1	BRAF	No	6	IQGAP1, HSPA8, AKT1, HSP90AB1, SFN, YWHAZ
CTNNB1	TLR4	No	2	SMAD3, HSPA8
CTNNB1	APC	Yes	32	LATS2, DLGAP1, STRN3, XPO1, SIAH1, BTRC, CTBP1, MUC1, ERBB2IP, NHSL1, CEP128, MAPRE1, AXIN1, COPS5, CTNNA1, NUP153, FBXW11, APC, SFN, APC2, JUP, AXIN2, TFAP2A, AP2M1, EPAS1, GSK3B, AMER1, CREBBP, DVL2, HNRNPM, NUP98, RANBP2
CTNNB1	PTPRJ	Yes	4	LGALS9, PTPRJ, CTNND1, EGFR
AKT1	AXIN2	No	5	NR4A1, GSK3A, GSK3B, SMAD7, CTNNB1
AKT1	RAD54B	No	1	MDM2
AKT1	PIK3CA	Yes	12	IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
AKT1	NRAS	No	2	DNAJB1, RAF1
AKT1	DCC	No	2	AR, APPL1
AKT1	AURKA	No	28	DDX5, MDM2, TUBB, HSP90AB1, HSPA5, IKBKG, THRSP, APP, NPM1, NCOR2, CHUK, CTNNB1, YBX1, PPP1CC, S100A14, HSPA9, PPP1CB, IKBKB, HSP90AA1, RQCD1, MTA3, GSK3B, BRCA1, HSPA8, CSNK2A1, CDC37, PPP1CA, EPSTI1
AKT1	DLC1	Yes	1	AKT1
AKT1	FLCN	No	1	APP
AKT1	TRIM28	No	22	MDM2, EZH2, VIM, NPM1, ARRB2, HDAC3, SKI, MAPKAPK2, DNMT1, PPP1CC, SIRT1, SIRT6, SETDB1, PPP1CB, NFE2L2, NR4A1, SMARCC1, NOTCH1, ILK, CREBBP, PPP1CA, SFN
AKT1	PLA2G2A	No	4	UCHL1, VIM, USP4, USP8
AKT1	EP300	Yes	53	KAT2B, AR, MDM2, ACTA1, GATA2, SNAI1, TNK2, SMAD4, FHL1, MAP3K5, CREB1, HSPA5, CTBP1, SKP2, COMMD1, MAPK8, MAPT, BRCA1, SMAD7, KAT6A, NPM1, NCOR2, HDAC3, SMAD3, CHUK, FOXO1, CLTC, MAPK14, YWHAZ, CDKN1A, CTNNB1, GAPDH, PRKDC, HIST2H2BE, RARA, RPS6KB1, NR4A1, SMAD2, AKT1, TCL1A, EP300, FOXO3, NOTCH1, CREBBP, PRKCB, ACTB, YBX1, DDX5, PPP2CA, SIRT1, ESR1, GATA1, IRF3
AKT1	FGFR3	No	5	HSPA4, HSPA8, CDC37, HSP90AA1, HSP90AB1
AKT1	TP53	No	74	KAT2B, BCL2L1, PIAS1, ZHX1, VCP, PSMC5, YWHAE, DDX5, SRC, CREB1, VIM, APOH, HSP90AB1, HSPA5, CTBP1, STUB1, IQGAP1, TNK2, MDM2, TUBB, MAPK8, YBX1, GSK3B, MDH1, BRCA1, SMAD7, STK4, SKI, DNAJB1, SMAD3, DAB2IP, TBC1D4, DNMT1, MAPK14, APPL1, ALYREF, YWHAZ, HSPA9, SFN, PIAS2, GAPDH, PRKDC, SMARCB1, MAPK9, CLTC, SMAD2, IKBKB, MUL1, NR4A1, HSP90AA1, PTEN, NPM1, PPP2R1A, PPP3CA, EP300, FOXO3, KAT6A, SMARCC1, CREBBP, PPP1CC, HSPA8, SNAI1, CSNK2A1, HSPA4, ACTB, MTOR, CDKN1A, PPP1CA, CHUK, HSPB1, SIRT1, ESR1, TPM4, UCHL1
AKT1	CCND1	No	14	KAT2B, CDKN1A, HSPA8, TSC2, EP300, AR, CDKN1C, HDAC3, PPP1CB, ESR1, BRCA1, GSK3B, PPP1CC, CDKN1B
AKT1	PTPN12	No	2	EGFR, APP
AKT1	MCC	No	4	PPP2R1A, CLTC, APP, VCP
AKT1	KAT5	No	23	AR, MDM2, APP, TRIB3, LDHA, ACTA1, CREB1, HDAC3, DNMT1, BRCA1, SIRT1, TNK2, GAPDH, PRKDC, HSP90AA1, ACTB, EP300, NOTCH1, CREBBP, GET4, YWHAG, ESR1, JADE1
AKT1	TLR2	No	4	CREBBP, IRAK1, EGFR, IRF3
AKT1	BRAF	Yes	17	CCDC88A, HSPA9, HSPA8, HSP90AB1, YWHAE, BRAF, CDC37, IQGAP1, HSP90AA1, RAF1, YWHAG, NEDD4, SFN, HSPA5, AKT1, BAD, YWHAZ
AKT1	TLR4	No	9	HSPA8, PRKCZ, TBK1, HSPA4, TRAF6, SMAD3, SRC, IRAK1, STUB1
AKT1	APC	No	14	AGR3, MARK2, SFN, CTBP1, CREBBP, IL24, CASC3, CTNNB1, SETDB1, HSPA5, GSK3B, CSNK2A1, TFF1, ST14
AKT1	PTPRJ	No	5	EPSTI1, PLCG1, EGFR, CASC3, CTNNB1
ODC1	RAD54B	No	1	GORASP2
ODC1	EP300	No	1	KAT5
ODC1	TP53	No	3	KAT5, TK1, CSNK2B
ODC1	KAT5	Yes	2	KAT5, ODC1
ODC1	APC	No	1	CSNK2B
AXIN2	AURKA	No	3	CDC20, GSK3B, CTNNB1
AXIN2	FLCN	No	1	FBXW11
AXIN2	TRIM28	No	1	NR4A1
AXIN2	EP300	No	4	NR4A1, SMAD7, CTNNB1, CDC20
AXIN2	TP53	No	5	NR4A1, AXIN1, GSK3B, SMAD7, FBXW11
AXIN2	CCND1	No	1	GSK3B
AXIN2	APC	Yes	6	APC, AXIN1, FBXW11, CTNNB1, GSK3B, RNF146
AXIN2	PTPRJ	No	1	CTNNB1
RAD54B	AURKA	No	4	FUS, UBE2I, PSMA1, MDM2
RAD54B	TRIM28	No	2	UBE2I, MDM2
RAD54B	EP300	No	5	UBE2I, PRKAA1, MDM2, MDM4, COPS6
RAD54B	TP53	No	9	SUMO1, CSNK1E, HECW2, MDM2, MDM4, PLCG2, UBE2I, WRN, RAD51
RAD54B	MCC	No	1	CSNK1E
RAD54B	KAT5	No	4	UBE2I, GMCL1, MDM2, SUMO1
RAD54B	APC	No	1	CSNK1E
PIK3CA	NRAS	No	1	RPS20
PIK3CA	DCC	No	1	APPL1
PIK3CA	AURKA	No	7	NEDD9, DDX5, BEX2, FTL, IRS4, PSMC3IP, THRSP
PIK3CA	DLC1	No	1	AKT1
PIK3CA	TRIM28	No	4	NTRK1, HDAC1, NOTCH1, STAT1
PIK3CA	EP300	No	12	NOTCH1, AKT1, HDAC1, DDX5, SMAD2, ATR, PIK3R1, SMAD3, ESR1, GRB2, WDR5, STAT1
PIK3CA	FGFR3	No	1	GRB2
PIK3CA	TP53	No	16	UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
PIK3CA	CCND1	No	3	HDAC1, UBTF, ESR1
PIK3CA	PTPN12	No	4	NEDD9, NTRK1, GRB2, GSN
PIK3CA	KAT5	No	4	NOTCH1, HDAC1, UBTF, ESR1
PIK3CA	BRAF	No	3	HRAS, YWHAH, AKT1
PIK3CA	TLR4	No	1	SMAD3
PIK3CA	APC	No	1	IL24
PIK3CA	PTPRJ	No	1	GRB2
NRAS	AURKA	No	1	EEF1A1
NRAS	EP300	No	1	EEF1A1
NRAS	TP53	No	4	EEF1A1, ELAVL1, DNAJB1, VAT1
NRAS	CCND1	No	1	ELAVL1
NRAS	KAT5	No	1	RGL2
NRAS	BRAF	No	1	RAF1
DCC	AURKA	No	6	RPS10, RPL23, BARD1, RPS4X, RPL38, EZR
DCC	EP300	No	2	AR, MAPK1
DCC	TP53	No	16	RPL10A, RPS6, RPL5, MAPK3, RPS24, BARD1, MAPK1, PTK2, RPS4X, RPL28, RPS13, RPS10, RPL13, APPL1, RPL23, EIF2S2
DCC	CCND1	No	2	AR, MAPK1
DCC	MCC	No	1	EZR
DCC	KAT5	No	3	AR, BARD1, SIAH2
DCC	BRAF	No	2	MAPK1, MAPK3
DCC	APC	No	2	SIAH1, PTK2
AURKA	DLC1	No	1	DDB1
AURKA	FLCN	No	2	BTRC, APP
AURKA	TRIM28	Yes	16	VHL, HIST3H3, MDM2, PPP1CB, AURKA, CDKN2A, UBE2N, UBE2L3, TRIM28, PPP1CA, TP53, LARP7, NPM1, CBX3, UBE2I, PPP1CC
AURKA	PLA2G2A	No	2	USP2, USP47
AURKA	EP300	No	34	DDX5, HIST3H3, MDM2, ILF3, TFAP2A, RPL27, NPM1, AURKB, SNW1, CHUK, GTF3C2, TP73, KLF4, REL, HDAC6, DDB1, NCOR2, CALCOCO1, CTNNB1, BRCA1, CDC20, ILF2, VHL, ASCC1, TP53, EEF2, NFKB1, EEF1A1, BTRC, YBX1, SIRT2, HNRNPU, HSPA5, UBE2I
AURKA	FGFR3	No	5	HSPA8, CDC37, SRPK2, HSP90AA1, HSP90AB1
AURKA	TP53	Yes	91	DDX5, FTH1, TP53, RPL27, RPS19, SIRT7, PPP1CC, OTUB1, UBE2N, TRIM28, RPL11, RPLP2, SKP1, PTTG1, RPS14, BTRC, PLK1, HNRNPA1, RPS4X, HSP90AB1, SNW1, SETD2, HSPA5, TUBG1, NIN, LRPPRC, DDB1, HSPA2, HSPA9, RPS16, RPLP0, HSP90AA1, IRS4, RPS27, PRRC2C, HDAC2, RPS3A, NFKBIA, GADD45A, EEF1A1, TP73, RPL30, HSPA1A, MFAP4, DGCR14, LYZ, TUBA1C, CDKN2A, CHUK, TUBB4B, EEF2, RPL23, HNRNPA2B1, PCMT1, CEP55, VHL, PPP1CA, IKBKB, RPS3, DCAF7, BRCA1, RPL12, PDCD6, CSNK2A1, RPS10, HNRNPU, MDM2, AURKA, TFAP2A, TAF9, AURKB, IGF2BP1, CEP128, PML, NPM1, CELA2B, NCL, IGF2BP3, BARD1, ITPKC, SRPK1, MRPL24, GSK3B, UBE2I, HSPA8, MRPS22, UBB, PLK3, YBX1, TUBB, TCEAL4
AURKA	CCND1	No	14	CDKN2A, HSPA8, SKP1, TP73, USP2, HDAC2, PPP1CB, BTRC, XPO1, CDH13, PSMA6, BRCA1, GSK3B, PPP1CC
AURKA	PTPN12	No	2	NEDD9, APP
AURKA	MCC	No	6	VHL, IARS, TARS, EZR, EPRS, APP
AURKA	KAT5	No	18	VHL, UBE2I, HIST3H3, MDM2, TP73, HDAC6, KLF4, BARD1, TP53, PML, MAPRE1, HSP90AA1, ANGPTL4, CDKN2A, RPL30, NFKB1, BRCA1, APP
AURKA	BRAF	No	7	HSPA1A, HSPA8, CDC37, HSPA9, HSP90AA1, HSP90AB1, HSPA5
AURKA	TLR4	No	1	HSPA8
AURKA	APC	No	17	AMER1, DKK3, LATS2, FBXO30, CEP128, GSK3B, CSNK2A1, NAT2, BTRC, TFAP2A, PDLIM2, XPO1, CTNNB1, MAPRE1, HSPA5, RPS27, MAPRE2
AURKA	PTPRJ	No	4	LYPD3, EPSTI1, CTNND1, CTNNB1
DLC1	TRIM28	No	3	CUL1, CUL2, CUL3
DLC1	EP300	No	2	DDB1, AKT1
DLC1	TP53	No	2	DDB1, CUL4A
DLC1	CCND1	No	1	CUL1
DLC1	KAT5	No	1	CUL3
DLC1	BRAF	No	1	AKT1
FLCN	TRIM28	No	1	TP53BP1
FLCN	EP300	No	3	BTRC, TP53BP1, GAG-POL
FLCN	TP53	No	4	BTRC, MAP1LC3B, FBXW11, TP53BP1
FLCN	CCND1	No	1	BTRC
FLCN	PTPN12	No	1	APP
FLCN	MCC	No	1	APP
FLCN	KAT5	No	1	APP
FLCN	APC	No	2	BTRC, FBXW11
TRIM28	PLA2G2A	No	1	VIM
TRIM28	EP300	No	39	HIST3H3, CDK2, MDM2, TP53, MYB, IRF7, BMI1, STAT6, HIST1H3A, NCOR1, KDM1A, NPM1, SERTAD1, HDAC3, ZNF350, E2F1, SIRT1, VHL, SENP3, HDAC1, NOTCH1, MAGED1, NR4A1, RUVBL2, PARP1, SUMO2, UBE2I, STAT1, STAT3, UBE2D1, NR3C1, IRF1, TP53BP1, CEBPB, UBC, MYC, HHV8GK18_GP81, CREBBP, HIF1A
TRIM28	TP53	Yes	73	ATM, WWOX, RNF2, CDK2, MDM2, AURKA, TOPORS, SMURF1, ERBB4, LYN, VIM, CCDC8, TRIM24, BMI1, STAT6, CDKN2A, NCOR1, KDM1A, MAGEA2, CCT5, CCT3, SFN, RPA1, CCT8, COPS5, RPA2, CCT7, DNMT1, HDAC5, CHD3, SIRT1, VHL, NDN, RRP1B, LMNA, SENP3, SIN3A, HDAC1, OBSL1, CCT2, ZNF420, SET, TRIM28, MTA2, NPM1, PARP1, CHEK2, H2AFX, TADA2A, BRCC3, SMARCC1, TP53BP1, PPP1CC, UHRF1, NR3C1, PPP4C, UBE2I, SKI, HUWE1, UBE2N, ENAH, ZWINT, PPP1CA, TP53, CUL7, SMARCA4, UBC, NR4A1, MYC, IRF7, HHV8GK18_GP81, CREBBP, HIF1A
TRIM28	CCND1	No	9	STAT3, CDK2, HDAC1, PPP1CB, CUL1, HDAC3, CDKN2A, PPP1CC, CUL7
TRIM28	PTPN12	No	1	NTRK1
TRIM28	MCC	No	2	VHL, CBX5
TRIM28	KAT5	No	29	ATM, HIST3H3, MDM2, TP53, MYB, HIST1H3A, BMI1, HDAC3, DNMT1, LMNA, E2F1, SIRT1, VHL, CCT7, HDAC1, NOTCH1, RUVBL2, H2AFX, UBE2I, CDKN2A, STAT3, UHRF1, NR3C1, TRIM23, CREBBP, CCDC8, MYC, HHV8GK18_GP81, CUL3
TRIM28	TLR2	No	1	CREBBP
TRIM28	BRAF	No	3	YWHAQ, ARAF, SFN
TRIM28	TLR4	No	2	SERTAD1, PPP4C
TRIM28	APC	No	10	RPA2, NUP214, CREBBP, HTRA2, CEP250, COPS5, SFN, UBC, SETDB1, YWHAQ
TRIM28	PTPRJ	No	1	FBXO6
PLA2G2A	EP300	No	1	BAG6
PLA2G2A	TP53	No	3	UCHL1, VIM, USP7
PLA2G2A	CCND1	No	1	USP2
PLA2G2A	PTPN12	No	1	BAG6
PLA2G2A	KAT5	No	2	SENP6, USP7
EP300	FGFR3	No	2	GTF3C1, GRB2
EP300	TP53	Yes	145	DDX5, PCNA, TDG, ETS2, RPL27, DDB1, PIN1, PPP1R13L, FOXO3, NCOA3, IRF7, RBBP5, PSMD10, MAPK14, SOX4, TNK2, NFATC1, NCOA1, TP53, RELA, CCNA2, PRDM2, FBXW8, TP63, YY1, ANXA2, ESR1, ZBTB16, TSG101, KAT2B, NFYA, BCL6, ZBTB33, MAP9, TWIST1, EWSR1, BMI1, ASH2L, KAT5, ERCC8, PTGS2, CLTC, PRMT1, ZNF148, EGR1, PRKCD, CRTC2, SETD1A, GPS2, KAT6A, NCOR1, NCOA2, PPARGC1A, SENP3, GAPDH, RPS26, ACTB, WDR82, ING4, ETS1, TAF1B, BRD7, SMAD1, TP73, HIF1A, GTF3C3, CXXC1, MDC1, BTRC, HSPA5, STAT6, CHUK, KDM1A, BANP, EEF2, RUNX2, TCF4, KLF5, CREB1, MTA1, SMAD3, MYBBP1A, APEX1, BRCA1, HIPK2, SIRT1, VHL, ACTA2, HDAC1, PRKDC, RB1, SMAD2, TFAP2A, SNW1, ZBTB8A, EP300, EEF1A1, TP53BP1, CDK2, WDR5, XRCC6, HNRNPU, TADA3, COPS2, MDM4, CDK1, MDM2, TBP, TP53BP2, HCVGP1, SNAI1, ZBTB17, VPR, NABP2, TAT, CTBP1, AURKB, ATR, SMAD7, NPM1, PPP2R5C, YWHAZ, SP1, CDKN1A, VDR, PLAGL1, MAPK8, ING2, UBC, PARP1, CARM1, MSH6, MYC, NFYB, NR3C1, CREBBP, MAPK1, YBX1, PPP1R13B, ING5, SP3, NR4A1, UBE2I, HHV8GK18_GP81, ING1
EP300	CCND1	Yes	27	KAT2B, AR, PCNA, CDK1, BTRC, SP1, CCND1, NCOA3, HDAC3, BRCA1, CDKN1A, THRA, HDAC1, ATF2, NCOA1, RELA, EP300, FBXW8, STAT3, NEUROD1, CDK2, MAPK1, MCM3, RB1, ESR1, TP73, MCM2
EP300	PTPN12	No	4	SMAD5, GRB2, DEK, BAG6
EP300	MCC	No	4	VHL, CLTC, KRT18, DYNC1I1
EP300	KAT5	Yes	62	NBN, ZBTB7B, HIST4H4, RELA, MDM2, HDAC6, TAT, KAT5, AR, TP53, HIST1H3A, MYB, HIST2H3C, HIST3H3, ZBTB33, PCNA, BMI1, HIST1H4A, TNK2, TP73, EP300, KLF4, ACTA1, CREB1, GAPDH, HDAC3, CBX8, BRCA1, MRE11A, SIRT1, SRCAP, VHL, GOLGA2, ESR1, ESR2, FOXP3, HDAC1, PRKDC, NOTCH1, ATF2, ACTB, RUVBL2, MYOD1, BCL3, ZBTB8A, NFKB1, UBE2I, CDK1, E2F1, MED23, STAT3, NR3C1, MORF4L1, HHV8GK18_GP81, CREBBP, ZBTB49, RB1, ZEB1, MAX, RAD50, MYC, PPARG
EP300	TLR2	No	2	CREBBP, IRF3
EP300	BRAF	No	7	TERF1, MAPK1, PAK2, AKT1, RPS6KB2, HSPA5, YWHAZ
EP300	TLR4	No	3	SERTAD1, UBQLN1, SMAD3
EP300	APC	No	15	GOLGA2, CTNNB1, CREBBP, SAV1, TFAP2A, UBC, BTRC, NUP98, MCM3AP, PCNA, EPAS1, ING5, HSPA5, CTBP1, PPP1R13B
EP300	PTPRJ	No	2	GRB2, CTNNB1
FGFR3	TP53	No	9	HNRNPL, HSPA8, HSPA1B, HSPA4, ATF3, RPL8, SOCS1, HSP90AA1, HSP90AB1
FGFR3	CCND1	No	1	HSPA8
FGFR3	PTPN12	No	1	GRB2
FGFR3	KAT5	No	2	ATF3, HSP90AA1
FGFR3	BRAF	No	4	CDC37, HSPA8, HSP90AA1, HSP90AB1
FGFR3	TLR4	No	2	HSPA4, HSPA8
FGFR3	PTPRJ	No	1	GRB2
TP53	CCND1	No	39	KAT2B, CDK1, PCNA, HERC5, MAPK1, CRYAB, TAF1, BTRC, RFC1, SLC25A5, CDKN2A, BRINP1, SP1, GSK3B, WDR77, NCOA3, RB1, THRB, BRCA1, CDKN1A, HDAC1, PRMT5, ELAVL1, RBX1, NCOA1, FBXO4, RANBP9, EP300, PPP1CC, FBXW8, HSPA8, CDK2, SKP1, HDAC2, UHRF2, ESR1, TP73, RELA, CUL7
TP53	PTPN12	No	1	GSN
TP53	MCC	No	8	VHL, CLTC, PSME3, CSNK1E, VCP, TPM3, CSNK1D, PPP2R1A
TP53	KAT5	Yes	63	ATM, SAT1, RELA, MDM2, H2AFX, SSX2IP, KAT5, ATF3, RRM2, TRRAP, CREB1, CDC42, RCHY1, TAT, TP73, PCNA, ZBTB33, HSP90AA1, HHV8GK18_GP81, TNK2, SUMO1, CCDC106, PDCD5, RPL30, BRD8, DLEU1, DNMT1, LMNA, BRCA1, ACTL6A, SIRT1, VHL, CCT7, GAPDH, PRKDC, HDAC1, BARD1, USP7, MAD2L1BP, TP53, NINL, MAP3K1, ZNF24, TRIM27, BMI1, ZBTB8A, EP300, UBE2I, CDK1, CDKN2A, EP400, UHRF1, NR3C1, HABP4, ARIH2, CREBBP, ACTB, CCDC8, RB1, ESR1, MYC, FAM173A, PML
TP53	TLR2	No	1	CREBBP
TP53	BRAF	No	14	HSPA9, HSPA8, HSP90AB1, PHKB, MAPK1, HRAS, IQGAP1, MAPK3, HSPA1A, HSP90AA1, YWHAE, SFN, HSPA5, YWHAZ
TP53	TLR4	No	6	HSPA8, PPP4C, HSPA4, SMAD3, SRC, STUB1
TP53	APC	No	37	CSNK1E, TFAP2A, BTRC, HSPA5, CTBP1, MUC1, CEP128, CSNK2B, PTK2, AXIN1, COPS5, RPA2, RPS27, SFN, FBXW11, ING5, HECTD1, ANXA7, RPGRIP1L, CSNK1A1, GIGYF2, TAF1, PCNA, RANBP9, GSK3B, CSNK2A1, CREBBP, MYO6, SENP1, LAMA4, TUBA4A, DVL2, HNRNPM, RANBP2, UBC, FLNA, PPP1R13B
CCND1	KAT5	No	15	STAT3, PCNA, TP73, HDAC1, AR, UBTF, ATF2, RB1, HDAC3, ESR1, CDKN2A, RELA, EP300, BRCA1, CDK1
CCND1	BRAF	No	2	HSPA8, MAPK1
CCND1	TLR4	No	1	HSPA8
CCND1	APC	No	6	TAF1, BTRC, XPO1, PCNA, RANBP9, GSK3B
CCND1	PTPRJ	No	2	KLK9, KLK7
PTPN12	MCC	No	1	APP
PTPN12	KAT5	No	1	APP
PTPN12	TLR2	No	1	EGFR
PTPN12	PTPRJ	No	2	GRB2, EGFR
MCC	KAT5	No	2	VHL, APP
MCC	APC	No	7	ERBB2IP, STRN4, STRN, CSNK1E, STRN3, SNRNP200, MYH10
KAT5	TLR2	No	1	CREBBP
KAT5	BRAF	No	3	YWHAG, PRKCE, HSP90AA1
KAT5	APC	No	4	CREBBP, GOLGA2, MAPRE1, PCNA
TLR2	TLR4	No	6	IRAK1, TIRAP, TLR1, TOLLIP, MYD88, LY96
TLR2	APC	No	1	CREBBP
TLR2	PTPRJ	No	1	EGFR
BRAF	TLR4	No	1	HSPA8
BRAF	APC	No	3	HSPA5, YWHAQ, SFN
TLR4	APC	No	1	HGS
APC	PTPRJ	No	5	CYP17A1, TRIM25, HOXC6, CASC3, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BUB1B	DLC1	No	1	FBXW7
CTNNB1	EP300	Yes	3	LRRFIP1, TCF7L2, CEBPA
CTNNB1	TP53	No	2	CREBBP, EP300
CTNNB1	APC	No	1	KCTD1
AURKA	EP300	No	1	TP53
AURKA	TP53	Yes	0
EP300	TP53	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MT-CO1	BAX	No	-	1	CYCS
MT-CO1	CTNNB1	No	-	1	MT-CO2
MT-CO1	AKT1	No	-	1	MT-CYB
BUB1B	MLH3	No	-	1	BRCA2
BUB1B	BAX	No	-	1	UBC
BUB1B	CTNNB1	No	-	13	KAT2B, BIRC5, PKP4, AJUBA, RPS27A, PLK1, CDC42, XPO1, INCENP, UBC, BRCA1, HDAC1, HDAC9
BUB1B	AKT1	No	-	13	KAT2B, BIRC5, UBB, UBE2D1, AURKA, RPS27A, BMI1, CDC42, CCNB1, UBC, BRCA1, PCGF2, HDAC9
BUB1B	ODC1	No	-	42	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
BUB1B	AXIN2	No	-	45	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, UBA52, PSMD4, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
BUB1B	PIK3CA	No	-	1	CDC42
BUB1B	DCC	No	-	1	CDC42
BUB1B	AURKA	Yes	binding	89	NDC80, INCENP, PSMC3, PSMC4, CLASP1, MAPRE2, NDEL1, PSMD1, PSME2, PSMB5, PSMD11, ANAPC5, UBE2C, PSMD5, BARD1, PSMB1, PSMD6, PSMD10, PSME3, UBE2D1, ANAPC2, PTTG1, PLK1, PSMD9, UBE2E1, ANAPC4, NEK2, UBB, PSMD3, KIF11, PSME1, MAPRE1, PSMD4, CENPA, PSMA7, BUB1, PSME4, PSMC5, PSMB2, CCNB1, UBC, PSMA3, CDC26, PSMC6, ANAPC10, PSMA8, PAFAH1B1, PSMA5, BRCA1, CDC20, BIRC5, PSMB10, PSMD12, PSMD7, CENPE, FZR1, PLK3, CDK1, PSMC1, PSMB3, PSMB11, CKAP5, CDC16, MAD2L1, ANAPC11, AURKB, KIF2C, PSMF1, RPS27A, PSMC2, PSMB4, CDC27, PSMA1, UBA52, CDC23, PSMB6, MAPRE3, PSMA6, BUB3, PSMD14, PSMD8, PSMD2, ANAPC1, ANAPC7, AJUBA, PSMD13, PSMB7, NDE1, PSMA4
BUB1B	DLC1	No	-	1	CDC42
BUB1B	FLCN	No	-	2	PKP4, SEC13
BUB1B	TRIM28	No	-	5	UBC, ZWINT, HDAC1, MIS12, SUMO1
BUB1B	EP300	No	-	8	KAT2B, UBE2D1, UBB, HDAC1, ANAPC5, UBC, HDAC9, BRCA1
BUB1B	TP53	No	-	31	KAT2B, STAG2, CDK1, XPO1, AURKB, HDAC9, RPS27A, SUMO1, UBB, BMI1, PSMD10, CLIP1, BRCA1, CDC20, UBA52, BIRC5, HDAC1, BARD1, RNF2, BUB1, PSME3, MAD1L1, BRCA2, UBE2D1, PTTG1, PLK3, AURKA, PLK1, CCNB1, UBC, CUL7
BUB1B	CCND1	No	-	58	KAT2B, PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, CDK1, XPO1, PSMA8, CDC42, PSMD14, PSMD1, PSMC3, PCGF2, HDAC9, PSMF1, RPS27A, PSMD3, SUMO1, PSMD2, UBB, CDC27, PSMD11, UBA52, PSME2, BRCA1, PSMA1, PSMD5, PSMD4, BIRC5, PSMD12, PSMB6, HDAC1, PSMB5, PSMA7, PSMA4, PSMA6, RBX1, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMC2, PSMD9, PSME4, PSMC5, PSMB2, PSMD13, CCNB1, PSMA5, UBC, PSMA3, PSMB7
BUB1B	KAT5	No	-	7	KAT2B, SUMO1, HDAC1, PLK1, MAPRE1, CCNB1, UBC
BUB1B	BRAF	No	-	1	UBC
BUB1B	TLR4	No	-	1	UBC
BUB1B	PTPRJ	No	-	1	UBC
MLH3	BAX	No	-	1	RPA1
MLH3	CTNNB1	No	-	1	CDK2
MLH3	RAD54B	No	-	7	WRN, MUS81, DMC1, BLM, RAD51C, RECQL, RAD51
MLH3	AURKA	No	-	1	CDK2
MLH3	TRIM28	No	-	0
MLH3	EP300	No	-	3	RPA1, CDK2, PCNA
MLH3	TP53	No	-	13	PMS2, BRCA2, CDK2, WRN, MLH1, RPA1, BLM, CDK4, PCNA, RPA3, MSH6, MSH2, RAD51
MLH3	CCND1	No	-	3	CDK4, CDK2, PCNA
MLH3	KAT5	No	-	0
BAX	CTNNB1	No	-	18	STAT3, AKT1, GJA1, MAPK8, EP300, CTBP1, CREBBP, NFKB1, BCL2L1, MMP2, RUNX3, JUN, BCL2, RELA, UBC, MYC, GSK3B, SIRT1
BAX	AKT1	Yes	binding, ptmod	33	BCL2L1, TIMP1, RUNX2, BCL2L2, TP53, XIAP, YAP1, BCL2L11, GJA1, NFKB1, PARK7, GSK3B, APAF1, CLU, SNCA, SIRT1, MCL1, JUN, PTEN, BAD, EP300, VDAC1, STAT3, BCL2, CREBBP, HSPA4, MMP2, RUNX3, IL6, RB1, UBC, MYC, RELA
BAX	ODC1	No	-	5	MAX, UBC, MYC, EP300, CREBBP
BAX	AXIN2	No	-	4	UBC, MYC, GSK3B, RUNX2
BAX	PIK3CA	No	-	13	SP1, BCL2L1, RELA, KITLG, SDC2, CAPN1, STAT3, TP53, AKT1, PTEN, MYC, GSK3B, NFKB1
BAX	AURKA	No	-	4	UBC, GSK3B, TP53, AKT1
BAX	DLC1	No	-	1	AKT1
BAX	TRIM28	No	-	5	UBC, MYC, SIRT1, STAT3, TP53
BAX	PLA2G2A	No	-	1	AKT1
BAX	EP300	Yes	activation, binding	22	AKT1, RUNX2, TP53, CTBP1, SP1, MAPK8, BCL2, RPA1, SIRT1, MAX, JUN, TAF1, RELA, NFKB1, STAT3, CREBBP, JMY, RUNX3, RB1, UBC, MYC, ING1
BAX	FGFR3	No	-	3	SH3GLB1, STAT3, KITLG
BAX	TP53	Yes	activation, binding	44	BCL2L1, AKT1, RUNX2, HSPA4, POU4F2, TAF1, TP53BP2, IL6, CTBP1, SP1, MAPK8, BCL2, NFKB1, PARK7, RB1, RPA1, CLU, SIRT1, MCL1, EP300, BID, SERPINB5, UBC, JUN, PTEN, PPP1R13B, GSK3B, APEX1, PMAIP1, CREBBP, STAT3, BBC3, XRCC6, BAK1, MMP2, RUNX3, BHLHE40, APAF1, GPX1, MAX, MYC, RELA, POU4F1, ING1
BAX	CCND1	No	-	24	PTEN, TP53, YAP1, CTBP1, SP1, MAPK8, BCL2, GSK3B, BHLHE40, TAF1, JUN, AKT1, RELA, EP300, PMAIP1, STAT3, CREBBP, NFKB1, GNB2L1, RUNX3, IL6, RB1, UBC, MYC
BAX	KAT5	No	-	11	STAT3, EP300, CREBBP, TP53, HSPD1, TAF1, MAX, MYC, NFKB1, UBC, SIRT1
BAX	TLR2	No	-	6	STAT3, MMP2, IL6, RELA, HSPD1, NFKB1
BAX	BRAF	No	-	3	UBC, MCL1, AKT1
BAX	TLR4	No	-	12	STAT3, AKT1, NFKB1, S100A8, HSPA4, MAPK8, UBC, IL6, TIMP1, HSPD1, RELA, GSK3B
BAX	PTPRJ	No	-	1	UBC
PDGFRL	AKT1	No	-	2	PHLPP2, PHLPP1
PDGFRL	FGFR3	No	-	2	PHLPP2, PHLPP1
CTNNB1	AKT1	Yes	activation, binding, catalysis	97	PTPN1, TJP1, CDC42, RAP1A, HDAC9, YWHAB, GJA1, HTT, YWHAH, ACTA1, FOXO3, GSK3A, BDNF, JUN, RELA, MYOD1, MMP9, MTOR, PIK3R1, YWHAG, TERT, FLT3, IRF3, KAT2B, AR, HNRNPA1, YWHAE, EZH2, EZR, PTGS2, FOS, RHOA, FOXO4, GLI1, IGF1, CBY1, CDH1, MMP2, CDKN1B, UBC, YWHAQ, HIF1A, ZYX, PPP2R5D, BCL2L1, SMAD4, BTRC, RAP1B, CHUK, IQGAP1, NFKB1, CCND1, AXIN1, ERBB3, FOXO1, SMAD3, BRCA1, SFN, FBXW11, PPP2R5A, BIRC5, HSPB3, NOTCH1, SMAD2, IKBKB, CDH2, VEGFA, EP300, MAPK14, NF2, RAC1, PRKCZ, IGF2, RUNX3, SIRT1, EFNA1, RAC3, PTPN11, FOXM1, HSPB2-C11ORF52, SNAI1, SNAI2, WNT3A, RPS27A, BCL2, SMAD7, PIK3CA, COPS5, YWHAZ, AKT2, SLC9A3R1, SRC, GSK3B, STAT3, ILK, CREBBP, MYC
CTNNB1	ODC1	No	-	4	UBC, MYC, EP300, CREBBP
CTNNB1	AXIN2	Yes	activation, binding	30	TCF7, SIAH1, TCF7L2, DVL2, CTNNBIP1, RPS27A, DACT1, CACYBP, SMAD7, CSNK1A1L, AXIN1, WNT3A, TBL1X, LRP6, GSK3A, LEF1, TBL1XR1, TCF7L1, APC2, CSNK1A1, DVL1, GSK3B, TNIK, MED12, DVL3, JUP, CDX1, CDX2, UBC, MYC
CTNNB1	PIK3CA	Yes	activation	59	MYC, BCL2L1, EGFR, MET, PRKCZ, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, RAP1A, RAP1B, VEGFA, CTNNA1, HGF, KDR, GSK3B, RHOA, ACTA1, PTK2, EPHA2, ERBB2, ERBB3, DLG1, SMAD2, SMAD3, YWHAZ, AKT2, IGF1, PRKCI, AR, PTPN1, NOTCH1, BDNF, SLC9A3R1, CDH1, AKT1, SRC, FYN, NFKB1, PRKCA, STAT3, GDNF, CDH2, RAC1, PTPN11, IGF1R, RELA, MTOR, PIK3R1, ERBB4, FLT3, EGF, GFRA1, EFNA1, FGFR1, CCND1, RAC3
CTNNB1	DCC	No	-	11	RAC1, EZR, RHOA, PTPN11, PTK2, SIAH1, CDC42, SRC, ROBO1, FYN, SLIT1
CTNNB1	AURKA	No	-	21	RPS27A, FOXM1, HIST3H3, AKT1, CPEB1, ILK, CDK2, AJUBA, BIRC5, YWHAE, CSNK1D, PLK1, UBC, TUBA1A, PPP2R5D, INCENP, CSNK1E, YWHAG, BRCA1, GSK3B, PRKACA
CTNNB1	DLC1	No	-	5	RAC3, RHOA, CDC42, AKT1, CDH1
CTNNB1	FLCN	No	-	2	CCND1, PKP4
CTNNB1	TRIM28	No	-	7	STAT3, HDAC1, SIRT1, UBC, FYN, MYC, CDKN1B
CTNNB1	PLA2G2A	No	-	2	PTGS2, AKT1
CTNNB1	EP300	Yes	activation	78	KAT2B, AR, RELA, FOXM1, CAMK4, IRF3, SMAD4, MYOD1, TGFBR1, MAPK14, TERT, HDAC9, FOS, KAT5, PTGS2, MAPK8, HNF1A, TCF7, PRKX, CTBP1, KLF4, SMAD7, SFN, TCF3, JUP, HDAC7, COPS5, MED12, NCOA2, PRKACG, CA9, FOXO4, FOXO3, HIPK2, TCF7L1, PRKACB, PRKACA, TCF4, FOXO1, LEF1, SMAD3, HDAC1, SOX9, NOTCH1, CDH1, UBC, MED1, TCF7L2, JUN, RAC3, MITF, SRC, CCND2, VEGFA, CEBPA, NFKB1, BRCA1, FHL2, STAT3, SMAD2, CDK2, PITX2, BCL2, PPARD, AKT1, CREBBP, HDAC2, ADIPOQ, CDX1, RUNX3, IL8, SIRT1, SMARCA4, SRY, MYC, CCND1, PML, HIF1A
CTNNB1	FGFR3	No	-	7	STAT3, HGF, FGF4, IGF1, EGF, VEGFA, EFNA1
CTNNB1	TP53	No	-	115	AKT1, MMP9, EGFR, HDAC9, FOXO3, MYO6, HTT, PTK2, RBBP5, TFF2, DKK1, MAPK12, CABLES1, CA9, ELAVL1, CSNK1A1, JUN, SPN, EP400, SKP1, BTRC, MTOR, YWHAG, SFN, MYOG, KAT2B, BCL2L1, CSNK1E, YWHAE, EZH2, PLK1, ASH2L, PTGS2, MAPK8, HGF, HIC1, ABL1, SMARCA4, PKD1, NUMB, MAPK9, CDH1, MITF, IGF1R, HDAC2, TERT, MMP2, PSENEN, UBC, HIF1A, NME1, AR, SMAD4, CSNK1D, VCAN, KAT5, FOS, CDK5R1, MAPK11, GSK3B, CCND1, CUL4A, AXIN1, SMAD3, FOXO1, BRCA1, HIPK2, SIRT1, BIRC5, HSPB3, HDAC1, PSEN1, NOTCH1, SMAD2, MED1, VEGFA, EP300, MAPK14, FHL2, CDK2, CSNK2A1, RUNX3, HNF4A, PTPN11, FOXM1, MET, HSPB2-C11ORF52, SNAI1, XPO1, SNAI2, CTBP1, MUC1, RPS27A, BCL2, PML, SMAD7, PIK3CA, EPHA2, ERBB2, COPS5, YWHAZ, RUVBL1, ID2, TOP2A, BDNF, NANOG, NFKB1, STAT3, CREBBP, RELA, IKBKB, DSC3, MYC, KLF4, ERBB4
CTNNB1	CCND1	Yes	activation	93	AKT1, CDC42, EGFR, HDAC9, MAPK14, ELAVL1, JUN, ABL1, KLK3, SKP1, MTOR, PIK3R1, TERT, CYR61, KAT2B, RAC1, HNRNPA1, TCF7, IL8, TCF7L2, ATOH1, MAPK8, CCNE1, KLF4, CDKN1B, HBP1, IGF1, CDH1, TGFBR2, HDAC2, CDX1, HNF4A, UBC, TLE4, FGFR1, SOX6, BMP4, PRL, CDC73, AR, SMAD4, HINT1, BTRC, FOS, CHUK, GSK3B, ERBB3, FOXO1, BRCA1, BIRC5, LEF1, HDAC1, NOTCH1, AES, CDH2, EP300, SMARCA4, FHL2, NF2, CDK2, CTNND1, IGF2, RUNX3, EZH2, RAC3, CUL1, XPO1, SNAI2, MAPK12, CTBP1, MUC1, RPS27A, HNF1A, BCL2, TLE1, PIK3CA, NR5A2, ERBB2, WNT3A, TCF7L1, CDX2, ID2, BDNF, SRC, CCND2, NFKB1, CDH4, STAT3, ILK, CREBBP, RELA, ADAM10, MYC
CTNNB1	PTPN12	No	-	4	SRC, CTNND1, FLT3, PTK2
CTNNB1	KAT5	Yes	activation, binding	34	KAT2B, AR, HIST3H3, RUVBL2, SOX9, NME1, HINT1, TRRAP, RUVBL1, CCND2, TCF4, EP300, KLF4, HDAC7, AXIN1, KLK3, GDNF, SIRT1, NOTCH1, LEF1, HDAC1, EP400, MED1, ABL1, NFKB1, STAT3, PITX2, CREBBP, PHF17, TCF7L2, PLK1, SMARCA4, UBC, MYC
CTNNB1	TLR2	No	-	15	HIF1A, STAT3, MMP9, RELA, RAC1, VCAN, MMP2, IKBKB, IL8, CHUK, EGFR, SRC, MAPK14, NFKB1, IRF3
CTNNB1	BRAF	No	-	15	YWHAB, IQGAP1, PRKCA, YWHAQ, YWHAH, YWHAE, MAP2K6, YWHAG, AKT1, RAP1A, UBC, PRKACA, RAP1B, SFN, YWHAZ
CTNNB1	TLR4	No	-	21	NOTCH1, STAT3, AKT1, NANOG, MAPK8, NFKB1, EGFR, IKBKB, RAC1, MTOR, UBC, MMP9, IL8, CHUK, RELA, SRC, CDX2, EZR, GSK3B, RHOA, IRF3
CTNNB1	PTPRJ	Yes	activation	12	FLT3, HGF, MET, RET, CTNND1, UBC, TJP1, CDH5, EGFR, KDR, SRC, CTNNA1
AKT1	ODC1	No	-	4	UBC, MYC, EP300, CREBBP
AKT1	AXIN2	No	-	13	GSK3A, CTNNB1, RUNX2, SMAD7, RPS27A, AXIN1, ESR1, PPP2CB, UBC, UBB, GSK3B, MYC, WNT3A
AKT1	RAD54B	No	-	1	S100A11
AKT1	PIK3CA	Yes	activation, binding	108	ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
AKT1	DCC	No	-	12	ELMO1, RAC1, APPL1, PLCG1, PTPN11, PAK1, CASP9, SRC, CDC42, EZR, DOCK1, RHOA
AKT1	AURKA	Yes	activation, binding	21	RALA, BIRC5, UBB, PPP2R5D, FOXM1, UBC, ARHGEF7, YWHAE, RPS27A, TP53, GADD45A, ILK, UBE2D1, MDM2, YWHAG, HSP90AA1, CCNB1, PPP2R1A, BRCA1, GSK3B, PAK1
AKT1	DLC1	Yes	binding	9	SERPINE1, RHOA, CDH1, INS, RPS6KB1, CDC42, RAC3, RHOC, RHOB
AKT1	FLCN	No	-	2	CCND1, RPS6KB1
AKT1	TRIM28	No	-	10	STAT3, MDM2, NCOR1, TP53, DNMT1, SIRT1, UBC, E2F1, MYC, CDKN1B
AKT1	PLA2G2A	Yes	binding, ptmod	2	PTGS2, PLA2G6
AKT1	EP300	Yes	activation, binding	95	MEF2D, TP53, CREB3L4, HDAC9, HSP90AA1, STAT5A, CTNNB1, SMAD5, FOXO3, BAX, CREB5, RPS6KB1, NR4A1, RELA, MYOD1, CREB3L2, TERT, ANGPTL4, IRF3, KAT2B, AR, NRIP1, RUNX2, CDKN1A, IGFBP3, UBB, SKP2, PTGS2, EGR1, FOS, HDAC3, FOXO4, RPS6KB2, NOTCH1, ESR1, GAPDH, RARA, MMP1, CDH1, FKBP4, GADD45A, MDM4, SERPINH1, UBC, MEF2C, HIF1A, PELP1, ATF4, SMAD4, CREB3L3, PARP1, SLC2A1, CREB1, CRTC2, NCOR1, NOS3, FOXM1, CCND1, TAL1, SMAD3, FOXO1, BRCA1, SFN, SIRT1, ARNT, CREB3, STAT3, ATF2, CREB3L1, VEGFA, MAPK14, EDN1, UBE2D1, RUNX3, RB1, RAC3, MDM2, RXRG, BCL2, SMAD7, NCOR2, COPS5, E2F1, CSF2, STAT5B, SMAD2, SRC, NFKB1, MEF2A, HSPA8, FABP4, CREBBP, JUN, MYC, LEP
AKT1	FGFR3	No	-	31	PGF, MDM2, SH2B1, FGF2, HSP90AB1, PDGFB, ANGPT2, HSP90AA1, ANGPT1, FGF1, SOS1, CBLB, SHC1, ANGPT4, IGF1, PHLPP1, HRAS, SOX2, PHLPP2, TRAF6, VEGFA, GRB2, BMP2, STAT3, FGF13, IRS1, INS, FGF9, EFNA1, FGF21, NEDD4
AKT1	TP53	Yes	binding, activation, expression	139	WWOX, RELA, CAV1, NPM1, HDAC9, VEGFA, FOXO3, HTT, CXCL12, STAT5A, COPS5, MAPK14, BAX, BDNF, JUN, NR4A1, FOXM1, MMP9, MTOR, MCL1, YWHAG, ESR1, KAT2B, BCL2L1, RUNX2, YWHAE, IGFBP3, SERPINE1, FGF2, STUB1, PTGS2, PIAS2, EGR1, PARK7, THBS1, RB1, CAT, CCNA2, SFN, TSC2, GAPDH, AR, CDH1, ANKRD2, HSP90AA1, LGALS3, AURKA, TERT, MMP2, GADD45A, S100B, MDM4, CCNB1, UBC, HIF1A, SP7, MMP1, SLC2A4, SMAD4, BTRC, CREB1, CFLAR, HSPA5, FOS, NCOR1, PHB, NOS3, PHF20, GDF15, NFKB1, CCND1, CD44, KRAS, BMI1, AXIN1, SMAD3, RAF1, BRCA1, SIRT1, WT1, BIRC5, FOXO1, HSPB3, HRAS, NOTCH1, SMAD2, NFE2L2, PTEN, PPP2R1A, ICAM1, EP300, SHH, UBE2D1, CHEK1, EZH2, RUNX3, APAF1, HMOX1, CDC25C, PTPN11, MDM2, HSPB2-C11ORF52, SNAI1, TOPBP1, SNAI2, WEE1, BAIAP2L1, UBB, RPS27A, BCL2, SMAD7, PPP2R4, PIK3CA, CLU, DNMT1, SKP2, TGFB1, PPP2R5C, YWHAZ, CDKN1A, SERPINH1, TRAF6, STAT5B, CTGF, PARP1, GSK3B, MYC, STAT3, HSPA8, POLI, CREBBP, HSPA4, IKBKB, YBX1, IL6, ATIC, LEP, MAP3K8, PDCD4
AKT1	CCND1	Yes	activation, binding	100	NRF1, PTEN, TP53, CDC42, HDAC9, PCGF2, STAT5A, CTNNB1, MAPK14, SLC3A2, F2R, BDNF, JUN, RELA, MTOR, INS, PIK3R1, ESR1, FHIT, KAT2B, RAC1, HNRNPA1, PDCD4, CSF2, EZH2, FGF2, LGALS3, FABP4, HDAC3, CHUK, HEXIM1, SRPK2, IGF1, TSC2, CDH1, TERT, GADD45A, RAC3, CCNB1, UBC, PELP1, ATF4, AR, SMAD4, BTRC, KRAS, YAP1, FOS, GCG, NFKB1, CD44, CREB1, ERBB3, FOXO1, BRCA1, WT1, BIRC5, RAF1, HRAS, NOTCH1, ATF2, CDH2, EP300, SHH, EDN1, NF2, MAP3K5, IGF2, RUNX3, ILK, RB1, CDKN1B, SNAI2, ARHGEF2, UBB, WNT3A, RPS27A, BCL2, PIK3CA, NCOR2, E2F1, CDKN1A, CYLD, STAT5B, SOX2, SRC, PAK1, GSK3B, STAT3, HSPA8, EGR1, GRN, IL3, CREBBP, YBX1, IL6, EIF4EBP1, MYC, LEP, FOXA1
AKT1	PTPN12	No	-	6	PDGFRB, CSK, FLT3, SRC, GRB2, SHC1
AKT1	KAT5	No	-	20	KAT2B, FKBP5, STAT3, CCNB1, MDM2, NOTCH1, EP300, CREBBP, CHEK1, AR, TP53, AXIN1, DNMT1, ATF2, CTNNB1, UBC, MYC, NFKB1, ESR1, SIRT1
AKT1	TLR2	No	-	23	RAC1, MMP9, SERPINE1, LGALS3, CHUK, HSP90B1, RETN, MAPK14, TLR4, CSF2, TRAF6, IKBKB, RELA, SRC, ICAM1, NFKB1, STAT3, HSPA8, MMP1, MMP2, IL6, HIF1A, IRF3
AKT1	BRAF	Yes	binding	24	HSP90AB1, YWHAE, PPP2CA, RRAS, RAP1A, RAP1B, YWHAB, IQGAP1, YWHAH, KRAS, RAF1, RPS6KB2, YWHAZ, RHEB, MCL1, HRAS, HSP90AA1, PPP2R2B, PPP2R1A, CDC37, YWHAG, SFN, UBC, YWHAQ
AKT1	TLR4	Yes	activation, binding, ptmod	34	RAC1, TIMP1, HSPA4, DECR1, MMP9, MTOR, EZR, CHUK, S1PR1, HSP90B1, GSK3B, RHOA, STAT5A, HMOX1, NOTCH1, TRAF6, IKBKB, NOX1, RELA, SRC, ICAM1, NFKB1, STAT3, HSPA8, BIRC2, STAT5B, NOX4, INS, IL6, EPOR, BMP2, UBC, BCL10, IRF3
AKT1	PTPRJ	No	-	9	FLT3, PDGFRB, LCK, UBC, TJP1, CTNNB1, SRC, GAB1, PDGFB
ODC1	AXIN2	No	-	43	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, MYC, PSMA3, PSMB7
ODC1	PIK3CA	No	-	1	MYC
ODC1	AURKA	No	-	44	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, OAZ1, PSMC3, PSMD1, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, AZI1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSMD9, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
ODC1	TRIM28	No	-	2	UBC, MYC
ODC1	EP300	Yes	activation, binding	4	MAX, UBC, MYC, CREBBP
ODC1	TP53	No	-	8	PSME3, CREBBP, UBC, MAX, NQO1, EP300, MYC, PSMD10
ODC1	CCND1	No	-	45	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, EP300, PSMD10, PSMD7, PSME3, PSMB5, PSME4, CREBBP, PSMC5, PSMB2, PSMD13, PSMA5, UBC, MYC, PSMA3, PSMB7
ODC1	KAT5	No	-	5	MAX, UBC, MYC, EP300, CREBBP
ODC1	BRAF	No	-	1	UBC
ODC1	TLR4	No	-	1	UBC
ODC1	PTPRJ	No	-	1	UBC
AXIN2	PIK3CA	No	-	4	MYC, GSK3B, ESR1, CTNNB1
AXIN2	DCC	No	-	1	SIAH1
AXIN2	AURKA	No	-	47	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMD3, PSMC2, GSK3B, PSMD2, PSMD11, UBA52, PSME2, PSMA1, PKD2, PSMD4, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
AXIN2	TRIM28	No	-	2	UBC, MYC
AXIN2	EP300	No	-	14	LEF1, RUNX2, TCF7, TCF7L1, SMAD7, TCF7L2, CDX1, JUP, ESR1, CTNNB1, UBC, UBB, MYC, MED12
AXIN2	TP53	No	-	13	RPS27A, PSME3, RUNX2, UBA52, SMAD7, CSNK1A1, AXIN1, ESR1, UBC, UBB, GSK3B, MYC, PSMD10
AXIN2	CCND1	No	-	58	PSMC4, PSME1, PSMC1, PSMC6, TCF7, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD9, PSMC3, PSMD1, PSMF1, PSMD3, PSMB3, PSMC2, GSK3B, PSMD2, PSMD11, WNT1, UBA52, WNT3A, CTNNB1, PSMA1, WNT5A, PSMD4, ESR1, LEF1, PSMB6, PSMD5, PSMA7, RPS27A, PSMA6, TCF7L1, PSMB1, PSMB10, PSMD8, PSME2, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, TCF7L2, CDX1, PSMB2, PSMD13, CDX2, PSMA5, UBC, MYC, PSMA3, PSMB7, PSMA4
AXIN2	KAT5	No	-	7	ESR1, LEF1, TCF7L2, AXIN1, CTNNB1, UBC, MYC
AXIN2	TLR2	No	-	1	WNT5A
AXIN2	BRAF	No	-	1	UBC
AXIN2	TLR4	No	-	3	UBC, GSK3B, CDX2
AXIN2	PTPRJ	No	-	2	UBC, CTNNB1
RAD54B	TRIM28	No	-	1	UBE2I
RAD54B	EP300	No	-	1	FEN1
RAD54B	TP53	No	-	4	UBE2I, RAD51, BLM, WRN
RAD54B	KAT5	No	-	1	UBE2I
PIK3CA	DCC	No	-	16	RAC1, CDC42, NTN1, MAP2K2, PTPN11, PTK2, UNC5B, CASP9, YES1, RHOA, SRC, PLCG1, FYN, APPL1, MAP2K1, BCAR1
PIK3CA	AURKA	No	-	3	GSK3B, TP53, AKT1
PIK3CA	DLC1	No	-	12	INS, TNS1, AKT1, RHOA, CDH1, RPS6KA1, RPS6KB1, CDC42, TNS3, TENC1, RHOG, RAC3
PIK3CA	FLCN	No	-	2	CCND1, RPS6KB1
PIK3CA	TRIM28	No	-	6	STAT3, NR3C1, TP53, CCND3, FYN, MYC
PIK3CA	PLA2G2A	No	-	4	GNAQ, GNA11, IL1B, AKT1
PIK3CA	EP300	No	-	29	AR, PELP1, AKT1, TP53, THRB, PGR, SP1, CCND1, CREB1, SMAD3, CTNNB1, RPS6KB2, CSF2, IL1B, THRA, NOTCH1, SMAD2, RPS6KB1, CDH1, RELA, SRC, VEGFA, NFKB1, STAT3, NR3C1, SGK1, ESR1, MYC, RAC3
PIK3CA	FGFR3	No	-	25	FIGF, IRS1, PGF, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, SOS1, CBLB, SHC1, PDGFA, HGF, HRAS, GRB2, VEGFA, VEGFC, STAT3, CBL, CBLC, INS, IGF1, EGF, EFNA1
PIK3CA	TP53	Yes	activation, expression	42	BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
PIK3CA	CCND1	Yes	activation	46	RAC1, PELP1, RELA, FIGF, AR, TP53, CTNND1, CDC42, KRAS, EGFR, PGR, AKT1, CCND3, CRKL, SP1, IL4, GSK3B, MAP2K1, CREB1, ERBB2, ERBB3, CTNNB1, ESR1, CSF2, RAF1, HRAS, NOTCH1, BDNF, CDH1, CDH2, SRC, NFKB1, MYC, STAT3, IL3, AGAP2, MAP3K5, MTOR, INS, PIK3R1, PTEN, SGK1, IGF1, VEGFC, FGFR1, RAC3
PIK3CA	PTPN12	No	-	12	PXN, PDGFRB, GSN, CSK, JAK2, CTNND1, PTK2, FLT3, SRC, GRB2, SHC1, BCAR1
PIK3CA	KAT5	No	-	9	STAT3, AR, GDNF, ESR1, NOTCH1, TP53, CTNNB1, MYC, NFKB1
PIK3CA	TLR2	No	-	9	STAT3, RELA, IL4, RAC1, CSF2, PXN, EGFR, SRC, NFKB1
PIK3CA	BRAF	No	-	16	MAP2K2, KRAS, RAP1A, RPS6KA2, CRK, HRAS, RRAS, PRKCD, RAF1, AKT1, PRKCA, RPS6KB2, RAP1B, MRAS, YWHAZ, MAP2K1
PIK3CA	TLR4	No	-	21	NOTCH1, STAT3, EGFR, RAC1, NFKB1, RHOA, TREM2, S1PR1, JAK2, IL1B, INS, PLCG2, LYN, AKT1, RELA, IL4, SRC, SYK, GSK3B, MTOR, FCGR2A
PIK3CA	PTPRJ	No	-	14	CTNNB1, PDGFRB, MET, RET, FLT3, HGF, LCK, CTNND1, EGFR, KDR, SRC, PDGFB, GAB1, CTNNA1
DCC	AURKA	No	-	1	PAK1
DCC	DLC1	No	-	2	RHOA, CDC42
DCC	TRIM28	No	-	1	FYN
DCC	EP300	No	-	1	SRC
DCC	TP53	No	-	5	MYO10, NTN1, UNC5A, PTPN11, PTK2
DCC	CCND1	No	-	5	SRC, MAP2K1, CDC42, PAK1, RAC1
DCC	PTPN12	No	-	4	SRC, NCK1, BCAR1, PTK2
DCC	TLR2	No	-	2	SRC, RAC1
DCC	BRAF	No	-	2	MAP2K2, MAP2K1
DCC	TLR4	No	-	4	SRC, RHOA, EZR, RAC1
DCC	PTPRJ	No	-	1	SRC
AURKA	DLC1	No	-	1	AKT1
AURKA	TRIM28	No	-	3	UBC, TP53, MDM2
AURKA	PLA2G2A	No	-	1	AKT1
AURKA	EP300	No	-	14	PRKACA, FOXM1, GATA3, UBE2D1, CDK2, TP53, GADD45A, MDM2, HSP90AA1, AKT1, UBC, BRCA1, ANAPC5, UBB
AURKA	FGFR3	No	-	2	MDM2, HSP90AA1
AURKA	TP53	Yes	activation, binding	37	CDK1, CASP1, AKT1, FOXM1, YWHAE, BIRC5, CSNK1D, AURKB, UBB, RPS27A, CSNK1E, PLK4, PSMD10, BRCA1, CDC20, MAP9, MDM2, UBE2N, UBA52, BARD1, HSP90AA1, BUB1, PPP2R1A, GSK3B, HMMR, PSME3, CDK2, UBE2D1, PTTG1, PLK3, PLK1, GADD45A, YWHAG, CCNB1, UBC, KIF23, FBXW7
AURKA	CCND1	No	-	59	PSMC4, PSME1, CEP57, PSMB10, PSMB3, PSMA5, PSMB11, PSMB4, CDK1, TP53, PSMA8, PSMD14, PSMC1, PSMD1, PSMC3, PSMD9, PSMF1, CDK3, PSMB2, RPS27A, PSMC2, PSMC6, GSK3B, PSMD2, UBB, CDC27, PSMD11, PSME2, BRCA1, PSMA1, UBA52, PSMD4, BIRC5, PSMB6, PSMD5, PSMA7, PSMD3, PSMA6, PSMB1, AKT1, PSMD8, PAK1, PSMD6, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, CDK2, ILK, PSME4, PSMC5, GADD45A, PSMD13, CCNB1, UBC, PSMA3, PSMB7, PSMA4
AURKA	PTPN12	No	-	1	NEDD9
AURKA	KAT5	No	-	8	HIST3H3, MDM2, PLK1, MAPRE1, H3F3B, TP53, CCNB1, UBC
AURKA	TLR2	No	-	1	DCN
AURKA	BRAF	No	-	7	YWHAE, HSP90AA1, UBC, YWHAG, AKT1, PPP2R1A, PRKACA
AURKA	TLR4	No	-	5	UBC, GSK3B, UBE2N, AKT1, DCN
AURKA	PTPRJ	No	-	1	UBC
DLC1	FLCN	No	-	1	RPS6KB1
DLC1	PLA2G2A	No	-	1	AKT1
DLC1	EP300	No	-	4	RAC3, RPS6KB1, AKT1, CDH1
DLC1	FGFR3	No	-	1	INS
DLC1	TP53	No	-	3	AKT1, CDH1, SERPINE1
DLC1	CCND1	No	-	6	CDH1, INS, CDC42, AKT1, RHOBTB2, RAC3
DLC1	TLR2	No	-	1	SERPINE1
DLC1	BRAF	No	-	1	AKT1
DLC1	TLR4	No	-	3	INS, RHOA, AKT1
FLCN	EP300	No	-	2	CCND1, RPS6KB1
FLCN	TP53	No	-	1	CCND1
FLCN	CCND1	Yes	binding, activation, expression	0
TRIM28	EP300	No	-	15	MYC, STAT3, TFDP2, MDM2, NR3C1, IRF1, TP53, TFDP1, NCOR1, UBC, MYB, E2F1, SUMO2, HDAC1, SIRT1
TRIM28	FGFR3	No	-	2	STAT3, MDM2
TRIM28	TP53	Yes	activation, binding	22	ZNF274, MYB, TRIM24, DNMT3A, NCOR1, MDM2, SUMO1, DNMT1, TFDP1, SIRT1, HDAC1, SIN3A, H2AFX, SUMO2, MYC, STAT3, NR3C1, IRF1, TP53BP1, SETDB1, UBC, UBE2I
TRIM28	CCND1	No	-	13	MYC, STAT3, TFDP2, SUMO1, HDAC1, TP53, CCND3, MYB, TFDP1, UBC, E2F1, IRF1, CDKN1B
TRIM28	KAT5	No	-	13	MYC, STAT3, MYB, MDM2, SUMO1, HDAC1, TP53, DNMT1, UBC, RAD50, H2AFX, UBE2I, SIRT1
TRIM28	TLR2	No	-	1	STAT3
TRIM28	BRAF	No	-	1	UBC
TRIM28	TLR4	No	-	2	UBC, STAT3
TRIM28	PTPRJ	No	-	1	UBC
PLA2G2A	EP300	No	-	4	PTGS2, MAPK1, AKT1, IL1B
PLA2G2A	TP53	No	-	4	PTGS2, MAPK3, MAPK1, AKT1
PLA2G2A	CCND1	No	-	2	MAPK1, AKT1
PLA2G2A	BRAF	No	-	3	MAPK3, MAPK1, AKT1
PLA2G2A	TLR4	No	-	2	IL1B, AKT1
PLA2G2A	PTPRJ	No	-	2	MAPK1, MAPK3
EP300	FGFR3	No	-	4	STAT3, VEGFA, MDM2, HSP90AA1
EP300	TP53	Yes	activation	145	RELA, PCNA, ETS2, KLF2, HDAC9, RUNX1, PAX5, HSP90AA1, FOXO3, NCOA3, KAT6A, RPA1, STAT5A, MAPK14, BCL6, CDC25A, TFDP1, JUN, NR4A1, TAF1, AKT1, EPAS1, SUMO2, CREBBP, CA9, TP63, YY1, ESR1, MAX, ZBTB16, KAT2B, NFYA, RUNX2, TWIST1, IGFBP3, MYB, BDKRB2, EWSR1, UBB, SKP2, PTGS2, MAPK8, PRMT1, SENP3, EGR1, STAT6, KLF4, DDB1, DNAJB1, NOTCH1, PPARGC1A, SFN, ZNF148, GAPDH, CDH1, MMP1, MUC2, ING4, ETS1, IRF1, HDAC2, TERT, CCNE2, SIRT2, SERPINH1, UBC, SMARCA4, TP73, KLF5, HIF1A, MITF, SUMO3, AR, SMAD4, UBE2D1, FOSL1, KAT5, FOS, NCOR1, KDM1A, NOS3, FOXM1, ABCB1, CCND1, CREB1, MTA1, SMAD3, DDB2, FOXO1, BRCA1, HIPK2, SIRT1, VHL, HDAC1, NFYB, SMAD2, MED1, VEGFA, LEP, FHL2, NEUROD1, CDK2, IRF9, RBPJ, RUNX3, RB1, TADA3, CABIN1, MDM4, MDM2, TBP, BAX, NFATC2, CDK8, REL, CTBP1, GADD45A, BCL2, PML, SMAD7, COPS5, NCL, SP1, CDKN1A, VDR, BNIP3L, ING2, STAT5B, IVL, PARP1, CARM1, NFKB1, STAT3, HSPA8, NR3C1, DDX17, PPARG, SNAPC4, MAPK1, SGK1, ING5, SP3, MYC, MAF, ING1
EP300	CCND1	Yes	activation, binding	96	IRF2, PCNA, GATA4, MYBL2, TP53, PGR, HDAC9, NCOA3, STAT5A, EDN1, CTNNB1, MAPK14, ESR1, CDC25A, TFDP1, JUN, TAF1, AKT1, TFDP2, YY1, GLI3, SMARCA4, KAT2B, AR, TCF7, CDKN1A, IL8, TCF7L2, MYB, EWSR1, UBB, SP1, MAPK8, CARM1, EGR1, KLF4, HDAC3, TERT, ESR2, CDH1, ETS1, IRF1, HDAC2, CDX1, GADD45A, UBC, PELP1, ATF4, SMAD4, FOSL1, FOS, BCL6, KLF5, CREB1, FOXO1, BRCA1, H2AFZ, VHL, LEF1, HDAC1, NOTCH1, ATF2, LEP, FHL2, SMARCA2, NEUROD1, CDK2, RBPJ, RUNX3, RB1, MAML1, RAC3, NMI, ZBTB17, SNIP1, CTBP1, HNF1A, BCL2, NCOR2, E2F1, TCF7L1, CSF2, ING2, STAT5B, SRC, CCND2, NFKB1, STAT3, HSPA8, FABP4, CREBBP, MAPK1, E2F5, MYC, RELA, SGK1
EP300	PTPN12	No	-	1	SRC
EP300	KAT5	Yes	binding	41	KAT2B, KAT2A, MDM2, AR, TP53, TCF7L2, MYB, HIST1H3A, HIST1H4A, CCND2, SOX9, TCF4, KLF4, PTMA, HDAC7, CTNNB1, SRCAP, ESR1, SIRT1, VHL, NOTCH1, SMARCA4, LEF1, HDAC1, STAT3, ATF2, UBC, MED1, TAF1, BCL3, NFKB1, PAX6, SMARCA2, PITX2, YY1, H2AFZ, ING5, NCL, MAX, MYC, CREBBP
EP300	TLR2	No	-	13	STAT3, HSPA8, CD36, CSF2, IL8, MMP1, HSPA6, HIF1A, RELA, SRC, MAPK14, NFKB1, IRF3
EP300	BRAF	No	-	11	PRKACA, AKT1, CAMK2A, MAPK1, HSP90AA1, UBC, SFN, RPS6KB2, CAMK2D, CAMK2B, CAMK2G
EP300	TLR4	No	-	19	STAT3, STAT5A, HSPA8, AKT1, CD36, MAPK8, SPI1, NFKB1, NOTCH1, PCK1, IL1B, UBC, STAT5B, IL8, RELA, SRC, PPARA, EHHADH, IRF3
EP300	PTPRJ	No	-	5	VHL, UBC, SRC, MAPK1, CTNNB1
FGFR3	TP53	No	-	10	STAT3, MDM2, HGF, HRAS, PRMT5, TRAF6, HSP90AA1, ITCH, VEGFA, FGF2
FGFR3	CCND1	No	-	11	STAT3, FIGF, HRAS, FGF7, INS, IHH, IGF1, VEGFC, SOX2, FGF2, CRKL
FGFR3	PTPN12	No	-	2	GRB2, SHC1
FGFR3	KAT5	No	-	2	STAT3, MDM2
FGFR3	TLR2	No	-	2	STAT3, TRAF6
FGFR3	BRAF	No	-	4	CRK, HRAS, HSP90AA1, HSP90AB1
FGFR3	TLR4	No	-	5	INS, STAT3, FGF10, TRAF6, BMP2
FGFR3	PTPRJ	No	-	2	PDGFB, HGF
TP53	CCND1	Yes	activation	133	TXN, ATF3, AKT1, TAF1, PTK6, EGFR, HDAC9, PCNA, CDK5, NCOA3, CDK9, STAT5A, UBA52, PMAIP1, MAPK14, TOP1, CDC25A, TFDP1, BDNF, JUN, CDK4, ABL1, MTOR, FBXW8, PSME3, SKP1, YY1, STK11, BTRC, FLI1, RND3, ESR1, KAT2B, AR, PIN1, PDCD4, PAX2, MYB, CCL2, ISG15, EWSR1, UBB, SP1, MAPK8, CARM1, EGR1, KLF4, BRCA1, SMARCA4, TSC2, CDH1, PSMD10, ETS1, CCNK, IRF1, HDAC2, STAT5B, GADD45A, CCNB1, UBC, VRK1, E2F4, BCCIP, SMARCB1, SMAD4, FOSL1, KRAS, FOS, BANP, BCL6, SUMO1, NFKB1, KLF5, CD44, CREB1, RAF1, LEP, WT1, BIRC5, FOXO1, HDAC1, NOTCH1, PTEN, SHH, EP300, MAPK12, FHL2, NEUROD1, CDK2, EZH2, RBPJ, RUNX3, RB1, MNAT1, HNF4A, VHL, CDK1, CCNA1, XPO1, SNAI2, CCNH, LGALS3, CTBP1, FGF2, MUC1, RPS27A, BCL2, IL6, PIK3CA, ERBB2, DICER1, MAPK7, HRAS, COL18A1, CDKN1A, TERT, ING2, ID2, ELAVL1, GSK3B, JDP2, EPCAM, STAT3, HSPA8, BTG2, CREBBP, MAPK1, YBX1, BHLHE40, DYRK1A, MYC, RELA, SGK1
TP53	PTPN12	No	-	1	PTK2
TP53	KAT5	Yes	activation, binding	43	KAT2B, AR, MDM2, NME1, TAF1, ZNF668, MYB, CCDC8, ACTL6A, APP, RUVBL1, SUMO1, EP300, KLF4, RCHY1, PDCD5, CCNB1, AXIN1, DNMT1, EP400, ESR1, SIRT1, VHL, NOTCH1, SMARCA4, HDAC1, STAT3, UBC, MED1, ABL1, H2AFX, NFKB1, UBE2I, USP7, YY1, CHEK1, PIAS4, PLK1, NCL, ING5, MAX, MYC, CREBBP
TP53	TLR2	No	-	20	STAT3, MMP9, HSPA8, RELA, SERPINE1, HSPA9, LGALS3, IKBKB, HMGB1, VCAN, MMP2, MMP1, IL6, TRAF6, EGFR, MAPK14, SOCS1, NFKB1, ICAM1, HIF1A
TP53	BRAF	No	-	17	AKT1, MCL1, PRKCD, MAPK1, HRAS, MAPK3, HSP90AA1, UBC, YWHAE, RAF1, YWHAG, KRAS, SFN, PPP2R1A, PIN1, MAP3K1, YWHAZ
TP53	TLR4	No	-	31	EIF2AK2, NANOG, HSPA4, TICAM2, MMP9, EGFR, STAT5B, MAPK8, GSK3B, MAP3K1, STAT5A, MAP4K4, NOTCH1, HSPA9, UBE2N, STAT3, TRAF6, IKBKB, AKT1, ICAM1, NFKB1, DUSP1, HMGB1, HSPA8, ANXA2, LYN, MTOR, IL6, HMOX1, UBC, RELA
TP53	PTPRJ	No	-	7	VHL, HGF, MET, MAPK3, MAPK1, EGFR, UBC
CCND1	PTPN12	No	-	2	SRC, CTNND1
CCND1	KAT5	No	-	31	KAT2B, AR, TP53, HINT1, TCF7L2, MYB, CCND2, SUMO1, NFKB1, KLF4, KLK3, CTNNB1, ESR1, H2AFZ, VHL, NOTCH1, CCNB1, LEF1, HDAC1, STAT3, ATF2, TAF1, ABL1, EP300, SMARCA4, SMARCA2, YY1, ING3, UBC, MYC, CREBBP
CCND1	TLR2	No	-	18	VIP, STAT3, HSPA8, RELA, IL4, WNT5A, LGALS3, RAC1, IL8, CSF2, IL6, TSC22D3, EGFR, SRC, KNG1, NFKB1, MAPK14, CHUK
CCND1	BRAF	No	-	10	PIN1, HRAS, MAPK1, PAK4, RAF1, KRAS, AKT1, UBC, MAP2K3, MAP2K1
CCND1	TLR4	No	-	27	RAC1, AKT1, PRDX1, IL8, GRP, EGFR, KNG1, CHUK, CIRBP, MAPK8, IL4, NFKB1, IL6, STAT5A, NOTCH1, STAT5B, RELA, SRC, GSK3B, STAT3, HSPA8, CDK6, MTOR, INS, VIP, CDX2, UBC
CCND1	PTPRJ	No	-	7	VHL, EGFR, MAPK1, UBC, CTNND1, CTNNB1, SRC
PTPN12	TLR2	No	-	2	SRC, PXN
PTPN12	TLR4	No	-	2	SRC, JAK2
PTPN12	PTPRJ	No	-	4	SRC, CTNND1, FLT3, PDGFRB
KAT5	TLR2	No	-	3	HSPD1, STAT3, NFKB1
KAT5	BRAF	No	-	1	UBC
KAT5	TLR4	No	-	5	HSPD1, UBC, STAT3, NFKB1, NOTCH1
KAT5	PTPRJ	No	-	3	VHL, UBC, CTNNB1
TLR2	TLR4	Yes	activation	33	RAC1, EGFR, IL8, HSPD1, TOLLIP, DCN, KNG1, CHUK, HSP90B1, IL6, MAP3K7, CD14, SFTPA1, LY96, HSPA9, IRAK2, TICAM1, TIRAP, STAT3, TRAF6, IKBKB, TLR1, RELA, SRC, ICAM1, NFKB1, HMGB1, HSPA8, IL4, CD36, MMP9, VIP, IRF3
TLR2	PTPRJ	No	-	2	SRC, EGFR
BRAF	TLR4	No	-	3	UBC, MAP3K1, AKT1
BRAF	PTPRJ	No	-	3	UBC, MAPK1, MAPK3
TLR4	PTPRJ	No	-	3	SRC, UBC, EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
CTNNB1	EP300	Yes	TCF4-CTNNB1-EP300 complex;TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex	4	CREBBP, HDAC6, TCF4, SUMO1
CTNNB1	TP53	No	-	2	AXIN1, EP300
CTNNB1	APC	Yes	AXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex	2	AXIN1, GSK3B
NRAS	BRAF	No	-	1	RAF1
TRIM28	EP300	No	-	6	SMARCC1, HDAC1, RBL2, SMARCC2, SMARCA4, SMARCB1
EP300	TP53	Yes	p300-MDM2-p53 protein complex	2	TP53, MDM2
EP300	CCND1	No	-	1	PCNA
EP300	APC	No	-	1	CTNNB1
TP53	APC	No	-	1	AXIN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CTNNB1	APC	Yes	2	APC, CTNNB1
EP300	TP53	Yes	2	EP300, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	13	APC, BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, DCC, EP300, BRAF
HTLV-I infection	hsa05166	4.59	11	APC, BAX, AKT1, NRAS, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300
Colorectal cancer	hsa05210	6.52	10	APC, BAX, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, DCC, BRAF
Proteoglycans in cancer	hsa05205	5.02	9	AKT1, NRAS, CCND1, TP53, PIK3CA, CTNNB1, TLR4, BRAF, TLR2
Endometrial cancer	hsa05213	6.81	9	APC, AKT1, NRAS, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, BRAF
Hepatitis B	hsa05161	5.52	9	BAX, NRAS, CCND1, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
Prostate cancer	hsa05215	6.11	8	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300, BRAF
PI3K-Akt signaling pathway	hsa04151	4.21	8	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4, TLR2
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	7	APC, CTNNB1, NRAS, PIK3CA, FGFR3, AXIN2, AKT1
Thyroid hormone signaling pathway	hsa04919	5.82	7	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300
MicroRNAs in cancer	hsa05206	5.38	7	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, EP300
Melanoma	hsa05218	6.56	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Renal cell carcinoma	hsa05211	6.6	6	NRAS, BRAF, PIK3CA, AKT1, EP300, FLCN
Glioma	hsa05214	6.66	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Rap1 signaling pathway	hsa04015	4.97	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
Neurotrophin signaling pathway	hsa04722	5.78	6	BAX, NRAS, BRAF, PIK3CA, TP53, AKT1
Non-small cell lung cancer	hsa05223	6.88	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Viral carcinogenesis	hsa05203	5.08	6	BAX, NRAS, CCND1, PIK3CA, TP53, EP300
FoxO signaling pathway	hsa04068	5.63	6	NRAS, CCND1, PIK3CA, AKT1, EP300, BRAF
Chronic myeloid leukemia	hsa05220	6.48	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Wnt signaling pathway	hsa04310	5.49	6	APC, CCND1, TP53, AXIN2, CTNNB1, EP300
Measles	hsa05162	5.6	6	CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Bladder cancer	hsa05219	7.38	5	FGFR3, CCND1, NRAS, TP53, BRAF
Focal adhesion	hsa04510	4.92	5	CCND1, PIK3CA, CTNNB1, AKT1, BRAF
Pancreatic cancer	hsa05212	6.56	5	CCND1, AKT1, TP53, PIK3CA, BRAF
MAPK signaling pathway	hsa04010	4.63	5	FGFR3, BRAF, AKT1, NRAS, TP53
Thyroid cancer	hsa05216	7.48	5	CCND1, NRAS, CTNNB1, TP53, BRAF
Ras signaling pathway	hsa04014	4.9	5	FGFR3, PLA2G2A, NRAS, AKT1, PIK3CA
Central carbon metabolism in cancer	hsa05230	6.7	5	FGFR3, TP53, AKT1, NRAS, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	5	CCND1, PIK3CA, NRAS, AKT1, BRAF
Tuberculosis	hsa05152	5.17	5	BAX, EP300, AKT1, TLR2, TLR4
Hepatitis C	hsa05160	5.68	5	BRAF, NRAS, AKT1, TP53, PIK3CA
Regulation of actin cytoskeleton	hsa04810	4.9	5	APC, FGFR3, BRAF, NRAS, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	4	CCND1, NRAS, AKT1, PIK3CA
Small cell lung cancer	hsa05222	6.17	4	CCND1, TP53, AKT1, PIK3CA
Cell cycle	hsa04110	5.68	4	BUB1B, CCND1, EP300, TP53
Toll-like receptor signaling pathway	hsa04620	6.0	4	PIK3CA, AKT1, TLR2, TLR4
Basal cell carcinoma	hsa05217	6.79	4	APC, AXIN2, TP53, CTNNB1
cAMP signaling pathway	hsa04024	5.05	4	BRAF, EP300, PIK3CA, AKT1
Jak-STAT signaling pathway	hsa04630	5.44	4	CCND1, EP300, AKT1, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	4	AKT1, PIK3CA, TLR2, TLR4
HIF-1 signaling pathway	hsa04066	5.9	4	AKT1, EP300, TLR4, PIK3CA
Insulin signaling pathway	hsa04910	5.55	4	BRAF, NRAS, AKT1, PIK3CA
Hippo signaling pathway	hsa04390	5.37	4	APC, CCND1, AXIN2, CTNNB1
Epstein-Barr virus infection	hsa05169	4.97	4	AKT1, EP300, TP53, PIK3CA
Toxoplasmosis	hsa05145	5.71	4	PIK3CA, AKT1, TLR2, TLR4
Influenza A	hsa05164	5.21	4	AKT1, EP300, TLR4, PIK3CA
Apoptosis	hsa04210	6.23	4	BAX, TP53, AKT1, PIK3CA
Huntington's disease	hsa05016	5.17	4	MT-CO1, EP300, BAX, TP53
Chemokine signaling pathway	hsa04062	5.19	4	BRAF, AKT1, NRAS, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	4	MT-CO1, AKT1, BAX, PIK3CA
ErbB signaling pathway	hsa04012	6.15	4	BRAF, NRAS, AKT1, PIK3CA
Melanogenesis	hsa04916	5.97	3	EP300, NRAS, CTNNB1
T cell receptor signaling pathway	hsa04660	6.01	3	AKT1, NRAS, PIK3CA
Amoebiasis	hsa05146	5.82	3	PIK3CA, TLR2, TLR4
Fc epsilon RI signaling pathway	hsa04664	6.6	3	AKT1, NRAS, PIK3CA
VEGF signaling pathway	hsa04370	6.77	3	NRAS, AKT1, PIK3CA
Natural killer cell mediated cytotoxicity	hsa04650	5.53	3	BRAF, NRAS, PIK3CA
Metabolic pathways	hsa01100	2.49	3	ODC1, PLA2G2A, MT-CO1
p53 signaling pathway	hsa04115	6.56	3	CCND1, BAX, TP53
Tight junction	hsa04530	5.53	3	NRAS, AKT1, CTNNB1
Long-term potentiation	hsa04720	6.64	3	BRAF, EP300, NRAS
B cell receptor signaling pathway	hsa04662	6.52	3	AKT1, NRAS, PIK3CA
Adherens junction	hsa04520	6.26	3	PTPRJ, EP300, CTNNB1
Herpes simplex infection	hsa05168	5.08	3	EP300, TP53, TLR2
Oxytocin signaling pathway	hsa04921	5.4	3	CCND1, NRAS, PIK3CA
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	BRAF, AKT1, PIK3CA
Estrogen signaling pathway	hsa04915	6.11	3	NRAS, AKT1, PIK3CA
Cholinergic synapse	hsa04725	5.88	3	AKT1, NRAS, PIK3CA
AMPK signaling pathway	hsa04152	5.8	3	CCND1, AKT1, PIK3CA
mTOR signaling pathway	hsa04150	6.72	3	BRAF, AKT1, PIK3CA
Choline metabolism in cancer	hsa05231	6.09	3	NRAS, AKT1, PIK3CA
Pathogenic Escherichia coli infection	hsa05130	6.99	2	TLR4, CTNNB1
Platelet activation	hsa04611	5.66	2	PIK3CA, AKT1
Legionellosis	hsa05134	6.88	2	TLR4, TLR2
cGMP-PKG signaling pathway	hsa04022	5.32	2	AKT1, PIK3CA
Osteoclast differentiation	hsa04380	5.64	2	PIK3CA, AKT1
Leukocyte transendothelial migration	hsa04670	5.74	2	PIK3CA, CTNNB1
Phagosome	hsa04145	5.27	2	TLR4, TLR2
Serotonergic synapse	hsa04726	5.84	2	BRAF, NRAS
Leishmaniasis	hsa05140	6.32	2	TLR4, TLR2
Malaria	hsa05144	7.15	2	TLR4, TLR2
Vascular smooth muscle contraction	hsa04270	5.74	2	PLA2G2A, BRAF
Bacterial invasion of epithelial cells	hsa05100	6.34	2	PIK3CA, CTNNB1
Rheumatoid arthritis	hsa05323	6.05	2	TLR4, TLR2
Inflammatory bowel disease (IBD)	hsa05321	6.43	2	TLR4, TLR2
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	PIK3CA, AKT1
TNF signaling pathway	hsa04668	5.96	2	PIK3CA, AKT1
Long-term depression	hsa04730	6.74	2	BRAF, NRAS
Carbohydrate digestion and absorption	hsa04973	7.28	2	PIK3CA, AKT1
Alcoholism	hsa05034	5.59	2	BRAF, NRAS
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01	2	BAX, TP53
Axon guidance	hsa04360	5.63	2	DCC, NRAS
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	AKT1, PIK3CA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Epstein-Barr virus infection (hsa05169)	-	4.97	0.024	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
Influenza A (hsa05164)	-	5.21	0.001	BAX, AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
HTLV-I infection (hsa05166)	-	4.59	0.0	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, KAT5, EP300, TLR4
Hepatitis C (hsa05160)	-	5.68	0.017	CTNNB1, NRAS, BRAF, TP53, PTPRJ, PIK3CA, AKT1, TLR2
Hepatitis B (hsa05161)	-	5.52	0.0	BAX, NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
Measles (hsa05162)	-	5.6	0.002	BAX, CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Vascular smooth muscle contraction (hsa04270)	-	5.74	0.003	PLA2G2A, PIK3CA, TP53, AKT1, DCC, BRAF, DLC1
Insulin signaling pathway (hsa04910)	-	5.55	0.01	NRAS, BRAF, PIK3CA, TP53, AKT1, EP300, TLR2
Ras signaling pathway (hsa04014)	-	4.9	0.0	BAX, NRAS, PLA2G2A, AURKA, TP53, BRAF, FGFR3, PIK3CA, AKT1, CCND1, TLR2
Hippo signaling pathway (hsa04390)	-	5.37	0.0	APC, BAX, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, EP300, DLC1
Prolactin signaling pathway (hsa04917)	-	6.6	0.001	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.038	TP53, AKT1, PIK3CA, CTNNB1, BRAF
MAPK signaling pathway (hsa04010)	-	4.63	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, BRAF, TLR2
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.001	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300
AMPK signaling pathway (hsa04152)	-	5.8	0.014	CCND1, PIK3CA, TP53, AKT1, EP300, TLR4
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.006	AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
Human Diseases	NEW	1.54	0.003	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
Cellular Processes	NEW	2.22	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Environmental Information Processing	NEW	1.71	0.023	MT-CO1, AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.001	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.0	APC, AKT1, NRAS, CCND1, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1
cGMP-PKG signaling pathway (hsa04022)	-	5.32	0.024	BAX, PIK3CA, TP53, AKT1, KAT5, EP300, TLR4
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.03	NRAS, BRAF, PIK3CA, TP53, AKT1, EP300
Osteoclast differentiation (hsa04380)	-	5.64	0.006	CTNNB1, TP53, TLR2, AKT1, PIK3CA, EP300, TLR4
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.001	AKT1, TP53, TLR2, CTNNB1, PIK3CA, EP300, TLR4
Inflammatory bowel disease (IBD) (hsa05321)	-	6.43	0.014	KAT5, EP300, PIK3CA, TLR2, TLR4
Toxoplasmosis (hsa05145)	-	5.71	0.003	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, TLR2
Wnt signaling pathway (hsa04310)	-	5.49	0.002	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, EP300
Cancers: Overview	NEW	2.72	0.001	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, ODC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Cancers: Specific types	NEW	4.1	0.0	APC, BAX, TLR2, CTNNB1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, DCC, EP300, BRAF, FLCN
Endocrine and metabolic diseases	NEW	4.75	0.002	MT-CO1, AKT1, CCND1, BAX, TP53, PTPRJ, PIK3CA, CTNNB1, EP300, TLR2
Infectious diseases: Bacterial	NEW	3.76	0.012	APC, BAX, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, TLR2
Substance dependence	NEW	4.77	0.008	AKT1, NRAS, CCND1, BUB1B, PIK3CA, CTNNB1, DCC, KAT5, BRAF
Infectious diseases: Viral	NEW	3.29	0.001	APC, BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
Infectious diseases: Parasitic	NEW	4.46	0.002	BAX, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.006	CTNNB1, TP53, TLR2, AKT1, PIK3CA, TLR4
NOD-like receptor signaling pathway (hsa04621)	NEW	6.88	0.005	TP53, CTNNB1, AURKA, AKT1, TLR2
RIG-I-like receptor signaling pathway (hsa04622)	NEW	6.62	0.006	TP53, CCND1, AKT1, CTNNB1, TLR2
Axon guidance (hsa04360)	-	5.63	0.038	NRAS, CCND1, TP53, AKT1, DCC, EP300
Tuberculosis (hsa05152)	-	5.17	0.013	BAX, CTNNB1, TP53, PIK3CA, AKT1, TLR4, EP300, TLR2
Salmonella infection (hsa05132)	NEW	6.29	0.007	CTNNB1, TP53, TLR2, AKT1, PIK3CA, TLR4
Legionellosis (hsa05134)	-	6.88	0.0	CCND1, PIK3CA, TLR4, AKT1, EP300, TLR2
Jak-STAT signaling pathway (hsa04630)	-	5.44	0.034	CCND1, PIK3CA, AKT1, KAT5, EP300, TLR4
Nervous system	NEW	3.77	0.0	APC, BAX, TLR2, AKT1, NRAS, PLA2G2A, TP53, BRAF, FGFR3, PIK3CA, CTNNB1, KAT5, EP300, CCND1, TLR4
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.001	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, BRAF, TLR2
Circulatory system	NEW	4.63	0.0	MT-CO1, AKT1, NRAS, PLA2G2A, TP53, PIK3CA, CTNNB1, DCC, KAT5, EP300, BRAF, DLC1
Endocrine system	NEW	3.26	0.0	PLA2G2A, MT-CO1, CTNNB1, NRAS, DLC1, CCND1, BUB1B, BAX, TP53, ODC1, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
Immune system	NEW	2.92	0.0	APC, PLA2G2A, BAX, AKT1, NRAS, PTPN12, AURKA, BRAF, KAT5, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, CCND1, TLR2
Cellular community	NEW	3.57	0.0	APC, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, PTPRJ, KAT5, EP300, BRAF, TLR2
Development	NEW	4.58	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, EP300, TLR2
Signal transduction	NEW	2.06	0.001	MT-CO1, AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Signaling molecules and interaction	NEW	3.09	0.048	BAX, AKT1, DLC1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, TLR2
Inflammatory mediator regulation of TRP channels (hsa04750)	NEW	6.07	0.01	BAX, CTNNB1, PLA2G2A, TP53, PIK3CA, AKT1
Small cell lung cancer (hsa05222)	-	6.17	0.0	AKT1, CCND1, AURKA, PIK3CA, TP53, CTNNB1, TLR4
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	AKT1, NRAS, CCND1, PIK3CA, CTNNB1, EP300, BRAF, TLR4
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300, BRAF
Cell motility	NEW	4.9	0.0	APC, BAX, CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, TLR2
Cell growth and death	NEW	4.41	0.002	BAX, AKT1, AURKA, CCND1, BUB1B, PIK3CA, TP53, TRIM28, CTNNB1, KAT5, EP300, ODC1, TLR4
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.0	APC, BAX, CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, TLR2
Alcoholism (hsa05034)	-	5.59	0.001	AKT1, NRAS, BRAF, BUB1B, PIK3CA, CTNNB1, DCC, KAT5
Melanoma (hsa05218)	-	6.56	0.0	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Bladder cancer (hsa05219)	-	7.38	0.0	NRAS, CCND1, TP53, FGFR3, AKT1, BRAF
FoxO signaling pathway (hsa04068)	-	5.63	0.0	AKT1, NRAS, CCND1, PIK3CA, TP53, CTNNB1, KAT5, EP300, BRAF
Pancreatic cancer (hsa05212)	-	6.56	0.001	BAX, CCND1, AURKA, PIK3CA, TP53, AKT1, BRAF
Endometrial cancer (hsa05213)	-	6.81	0.0	APC, AKT1, NRAS, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, EP300, BRAF
Colorectal cancer (hsa05210)	-	6.52	0.0	APC, BAX, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, DCC, BRAF
Renal cell carcinoma (hsa05211)	-	6.6	0.0	NRAS, CCND1, PIK3CA, AKT1, EP300, BRAF, FLCN
Thyroid cancer (hsa05216)	-	7.48	0.0	NRAS, CCND1, TP53, CTNNB1, EP300, BRAF
Basal cell carcinoma (hsa05217)	-	6.79	0.011	APC, AXIN2, TP53, CTNNB1
Glioma (hsa05214)	-	6.66	0.0	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Prostate cancer (hsa05215)	-	6.11	0.0	CTNNB1, NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300, BRAF
Focal adhesion (hsa04510)	-	4.92	0.01	CTNNB1, CCND1, AURKA, PIK3CA, TP53, AKT1, KAT5, BRAF
NF-kappa B signaling pathway (hsa04064)	NEW	6.21	0.003	BAX, CCND1, TP53, TLR4, AKT1, TLR2
Chemokine signaling pathway (hsa04062)	-	5.19	0.03	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF, TLR4
Apoptosis (hsa04210)	-	6.23	0.002	BAX, AURKA, PIK3CA, TP53, AKT1, ODC1
VEGF signaling pathway (hsa04370)	-	6.77	0.002	AKT1, PLA2G2A, EP300, NRAS, PIK3CA
Proteoglycans in cancer (hsa05205)	-	5.02	0.0	AKT1, NRAS, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, BRAF, TLR2
MicroRNAs in cancer (hsa05206)	-	5.38	0.0	APC, BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, EP300
Pathways in cancer (hsa05200)	-	3.98	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Viral carcinogenesis (hsa05203)	-	5.08	0.012	BAX, AKT1, NRAS, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, EP300, TLR4
Transcriptional misregulation in cancer (hsa05202)	NEW	5.21	0.004	BAX, CTNNB1, CCND1, TRIM28, TP53, AKT1, KAT5, EP300, TLR4
T cell receptor signaling pathway (hsa04660)	-	6.01	0.007	AKT1, NRAS, CCND1, PIK3CA, CTNNB1, TLR4
Type II diabetes mellitus (hsa04930)	NEW	7.12	0.002	AKT1, TP53, EP300, PIK3CA, TLR2
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.004	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1
Rap1 signaling pathway (hsa04015)	-	4.97	0.018	AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, BRAF
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
ErbB signaling pathway (hsa04012)	-	6.15	0.0	NRAS, CCND1, PIK3CA, TP53, AKT1, EP300, BRAF

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	14	APC, AKT1, NRAS, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, KAT5, EP300, BRAF, DLC1
Immune System	R-HSA-168256	2.37	9	CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Innate Immune System	R-HSA-168249	3.17	9	CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Disease	R-HSA-1643685	3.33	9	APC, CTNNB1, NRAS, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Cell Cycle	R-HSA-1640170	3.89	7	BUB1B, CCND1, AURKA, TP53, KAT5, EP300, MLH3
Programmed Cell Death	R-HSA-5357801	5.65	7	APC, BAX, CTNNB1, TP53, AKT1, DCC, TLR4
Developmental Biology	R-HSA-1266738	3.48	7	CTNNB1, NRAS, BRAF, FGFR3, AKT1, DCC, EP300
Apoptosis	R-HSA-109581	5.68	7	APC, BAX, CTNNB1, TP53, AKT1, DCC, TLR4
Diseases of signal transduction	R-HSA-5663202	4.89	7	APC, AKT1, NRAS, PIK3CA, FGFR3, CTNNB1, EP300
Signaling by VEGF	R-HSA-194138	4.66	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
Signaling by Wnt	R-HSA-195721	4.79	6	APC, CTNNB1, AXIN2, AKT1, KAT5, EP300
Metabolism	R-HSA-1430728	2.34	6	MT-CO1, PLA2G2A, PIK3CA, AKT1, ODC1, EP300
TCF dependent signaling in response to WNT	R-HSA-201681	5.36	6	APC, CTNNB1, AXIN2, AKT1, KAT5, EP300
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
IGF1R signaling cascade	R-HSA-2428924	4.85	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Downstream signal transduction	R-HSA-186763	4.65	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by ERBB4	R-HSA-1236394	4.7	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by Insulin receptor	R-HSA-74752	4.73	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Insulin receptor signalling cascade	R-HSA-74751	4.85	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signalling by NGF	R-HSA-166520	4.23	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
IRS-mediated signalling	R-HSA-112399	4.87	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR4	R-HSA-5654743	4.69	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by FGFR3	R-HSA-5654741	4.69	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Signaling by FGFR	R-HSA-190236	4.67	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by SCF-KIT	R-HSA-1433557	4.73	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by PDGF	R-HSA-186797	4.53	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
DAP12 signaling	R-HSA-2424491	4.64	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by EGFR	R-HSA-177929	4.59	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by GPCR	R-HSA-372790	2.68	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR2	R-HSA-5654738	4.68	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR1	R-HSA-5654736	4.69	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
DAP12 interactions	R-HSA-2172127	4.56	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by ERBB2	R-HSA-1227986	4.66	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Hemostasis	R-HSA-109582	3.98	5	TP53, EP300, NRAS, AKT1, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	4	FGFR3, BRAF, NRAS, PIK3CA
formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.18	4	AXIN2, KAT5, EP300, CTNNB1
Signaling by Interleukins	R-HSA-449147	4.71	4	FGFR3, BRAF, NRAS, PIK3CA
Generic Transcription Pathway	R-HSA-212436	3.86	4	MT-CO1, TP53, AKT1, TRIM28
Gene Expression	R-HSA-74160	2.72	4	MT-CO1, TP53, AKT1, TRIM28
Interleukin receptor SHC signaling	R-HSA-912526	5.09	4	FGFR3, BRAF, NRAS, PIK3CA
Interleukin-2 signaling	R-HSA-451927	5.05	4	FGFR3, BRAF, NRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	4	FGFR3, NRAS, AKT1, PIK3CA
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	4	FGFR3, BRAF, NRAS, PIK3CA
Cell Cycle, Mitotic	R-HSA-69278	4.16	4	BUB1B, AURKA, CCND1, EP300
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	4	FGFR3, BRAF, NRAS, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	4	FGFR3, AKT1, NRAS, PIK3CA
Axon guidance	R-HSA-422475	3.93	4	DCC, FGFR3, BRAF, NRAS
Adaptive Immune System	R-HSA-1280218	3.19	4	FGFR3, AKT1, NRAS, PIK3CA
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	3	MT-CO1, AKT1, TP53
PI3K/AKT activation	R-HSA-198203	6.32	3	FGFR3, AKT1, PIK3CA
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	3	FGFR3, NRAS, PIK3CA
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	FGFR3, BRAF, NRAS
Signaling by Rho GTPases	R-HSA-194315	4.43	3	BUB1B, DLC1, CTNNB1
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	3	FGFR3, PIK3CA, AKT1
Signaling by NOTCH	R-HSA-157118	6.2	3	CCND1, EP300, TP53
Cell-Cell communication	R-HSA-1500931	5.87	3	DCC, PIK3CA, CTNNB1
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59	3	APC, AKT1, CTNNB1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	FGFR3, BRAF, NRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	FGFR3, BRAF, NRAS
MAPK family signaling cascades	R-HSA-5683057	4.89	3	FGFR3, BRAF, NRAS
PIP3 activates AKT signaling	R-HSA-1257604	6.37	3	FGFR3, PIK3CA, AKT1
PI3K Cascade	R-HSA-109704	6.68	3	FGFR3, PIK3CA, AKT1
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	3	FGFR3, PIK3CA, AKT1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	3	FGFR3, AKT1, PIK3CA
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	FGFR3, BRAF, NRAS
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	FGFR3, BRAF, NRAS
Cell Cycle Checkpoints	R-HSA-69620	5.64	3	KAT5, BUB1B, TP53
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	FGFR3, BRAF, NRAS
SOS-mediated signalling	R-HSA-112412	5.15	3	FGFR3, BRAF, NRAS
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	FGFR3, BRAF, NRAS
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	PLA2G2A, EP300, PIK3CA
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	3	MT-CO1, AKT1, TP53
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	3	FGFR3, PIK3CA, AKT1
Signaling by FGFR in disease	R-HSA-1226099	7.49	3	FGFR3, NRAS, PIK3CA
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	3	FGFR3, AKT1, PIK3CA
Signaling by Leptin	R-HSA-2586552	5.1	3	FGFR3, BRAF, NRAS
GAB1 signalosome	R-HSA-180292	6.31	3	FGFR3, AKT1, PIK3CA
Frs2-mediated activation	R-HSA-170968	5.12	3	FGFR3, BRAF, NRAS
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	FGFR3, BRAF, NRAS
Signalling to RAS	R-HSA-167044	5.08	3	FGFR3, BRAF, NRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	3	FGFR3, PIK3CA, AKT1
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.49	3	CCND1, EP300, TP53
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	FGFR3, BRAF, NRAS
Chromatin modifying enzymes	R-HSA-3247509	5.19	3	CCND1, EP300, KAT5
Prolonged ERK activation events	R-HSA-169893	5.11	3	FGFR3, BRAF, NRAS
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	FGFR3, BRAF, NRAS
Signalling to ERKs	R-HSA-187687	5.04	3	FGFR3, BRAF, NRAS
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.12	3	CCND1, EP300, TP53
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	3	FGFR3, PIK3CA, AKT1
ARMS-mediated activation	R-HSA-170984	5.12	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	3	FGFR3, PIK3CA, AKT1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	FGFR3, BRAF, NRAS
Chromatin organization	R-HSA-4839726	5.19	3	CCND1, EP300, KAT5
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	FGFR3, BRAF, NRAS
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73	3	BAX, TP53, AKT1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	FGFR3, BRAF, NRAS
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	PIK3CA, AKT1
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51	2	TLR4, TLR2
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11	2	TLR4, TLR2
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05	2	FGFR3, PIK3CA
MAP2K and MAPK activation	R-HSA-5674135	7.66	2	BRAF, NRAS
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	NRAS, PIK3CA
Apoptotic execution phase	R-HSA-75153	7.28	2	APC, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.03	2	APC, CTNNB1
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.34	2	TLR4, TLR2
Activated TLR4 signalling	R-HSA-166054	6.27	2	TLR4, TLR2
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.52	2	TLR4, TLR2
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	2	NRAS, PIK3CA
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88	2	EP300, TP53
binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	10.18	2	AXIN2, CTNNB1
RAF activation	R-HSA-5673000	8.34	2	BRAF, NRAS
HATs acetylate histones	R-HSA-3214847	6.23	2	KAT5, EP300
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.61	2	BUB1B, AURKA
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	2	NRAS, PIK3CA
S45 mutants of beta-catenin aren't phosphorylated	R-HSA-5358751	9.08	2	APC, CTNNB1
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	2	APC, CTNNB1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	PIK3CA, AKT1
Phospholipid metabolism	R-HSA-1483257	5.83	2	PLA2G2A, PIK3CA
Beta-catenin phosphorylation cascade	R-HSA-196299	8.89	2	APC, CTNNB1
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.64	2	APC, CTNNB1
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	2	NRAS, PIK3CA
CD28 co-stimulation	R-HSA-389356	7.98	2	AKT1, PIK3CA
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	PIK3CA, AKT1
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	2	NRAS, PIK3CA
G2/M Transition	R-HSA-69275	6.06	2	AURKA, EP300
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	EP300, NRAS
T41 mutants of beta-catenin aren't phosphorylated	R-HSA-5358752	9.08	2	APC, CTNNB1
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	TLR4, TLR2
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.81	2	FGFR3, NRAS
GPCR downstream signaling	R-HSA-388396	3.07	2	PIK3CA, AKT1
Caspase activation via extrinsic apoptotic signalig pathway	R-HSA-5357769	8.34	2	DCC, TLR4
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4	2	AKT1, PIK3CA
RHO GTPase Effectors	R-HSA-195258	4.94	2	BUB1B, CTNNB1
Regulation of mitotic cell cycle	R-HSA-453276	6.61	2	BUB1B, AURKA
Activation of BH3-only proteins	R-HSA-114452	8.34	2	TP53, AKT1
Mitotic G2-G2/M phases	R-HSA-453274	6.04	2	AURKA, EP300
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94	2	EP300, CTNNB1
Diseases of Immune System	R-HSA-5260271	8.34	2	TLR4, TLR2
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	2	NRAS, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	2	NRAS, PIK3CA
Toll-Like Receptors Cascades	R-HSA-168898	5.91	2	TLR4, TLR2
Negative regulation of MAPK pathway	R-HSA-5675221	7.66	2	BRAF, NRAS
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51	2	TLR4, TLR2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	10.66	2	EP300, CTNNB1
misspliced GSK3beta mutants stabilize beta-catenin	R-HSA-5339716	9.08	2	APC, CTNNB1
S33 mutants of beta-catenin aren't phosphorylated	R-HSA-5358747	9.08	2	APC, CTNNB1
S37 mutants of beta-catenin aren't phosphorylated	R-HSA-5358749	9.08	2	APC, CTNNB1
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.52	2	TLR4, TLR2
Signaling by WNT in cancer	R-HSA-4791275	7.89	2	APC, CTNNB1
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.12	2	FGFR3, BRAF
G-protein beta:gamma signalling	R-HSA-397795	7.31	2	AKT1, PIK3CA
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.59	2	EP300, NRAS
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	2	NRAS, PIK3CA
Tie2 Signaling	R-HSA-210993	8.81	2	NRAS, PIK3CA
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	TLR4, TLR2
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	R-HSA-4839743	9.08	2	APC, CTNNB1
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28	2	AKT1, CTNNB1
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	2	NRAS, PIK3CA
Cellular responses to stress	R-HSA-2262752	4.56	2	EP300, TP53
Costimulation by the CD28 family	R-HSA-388841	6.56	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
TRIF-mediated TLR3/TLR4 signaling (R-HSA-937061)	NEW	6.47	0.029	TP53, CCND1, TLR2, AKT1, TLR4
Signaling by PDGF (R-HSA-186797)	-	4.53	0.0	APC, BAX, NRAS, CCND1, PIK3CA, FGFR3, ODC1, TP53, AKT1, DCC, KAT5, EP300, BRAF, TLR4
Oxidative Stress Induced Senescence (R-HSA-2559580)	NEW	6.51	0.028	CCND1, EP300, TP53, AKT1, KAT5
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.012	FGFR3, NRAS, PIK3CA
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.0	APC, PTPN12, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, KAT5, AKT1, BRAF, TLR4
Toll Like Receptor 2 (TLR2) Cascade (R-HSA-181438)	-	6.51	0.04	TP53, CCND1, TLR2, AKT1, TLR4
Immune System (R-HSA-168256)	-	2.37	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Signaling by Rho GTPases (R-HSA-194315)	-	4.43	0.0	APC, AKT1, AURKA, CCND1, BUB1B, PIK3CA, TP53, TRIM28, CTNNB1, DCC, KAT5, EP300, DLC1
Signaling by the B Cell Receptor (BCR) (R-HSA-983705)	-	4.62	0.0	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, EP300, TLR4
Cell-Cell communication (R-HSA-1500931)	-	5.87	0.039	AKT1, PIK3CA, TP53, CTNNB1, DCC, TLR4
FGFR1 mutant receptor activation (R-HSA-1839124)	NEW	8.12	0.007	FGFR3, AKT1, CTNNB1, PIK3CA
Programmed Cell Death (R-HSA-5357801)	-	5.65	0.0	APC, BAX, CTNNB1, CCND1, DLC1, TP53, TLR4, PTPN12, DCC, AKT1, TLR2
Extracellular matrix organization (R-HSA-1474244)	NEW	4.91	0.009	CTNNB1, PTPN12, CCND1, AURKA, TP53, PIK3CA, AKT1, KAT5, BRAF
Downstream signal transduction (R-HSA-186763)	-	4.65	0.0	APC, BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, ODC1, EP300, BRAF, TLR4
deactivation of the beta-catenin transactivating complex (R-HSA-3769402)	-	7.59	0.001	APC, TP53, EP300, AKT1, CTNNB1
Cell Cycle (R-HSA-1640170)	-	3.89	0.001	APC, DLC1, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, AKT1, KAT5, EP300, MLH3
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.003	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Adaptive Immune System (R-HSA-1280218)	-	3.19	0.002	BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
Developmental Biology (R-HSA-1266738)	-	3.48	0.011	CTNNB1, NRAS, EP300, CCND1, AURKA, TP53, FGFR3, PTPRJ, PIK3CA, PTPN12, DCC, KAT5, AKT1, BRAF, TLR4
Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582)	NEW	6.77	0.005	CCND1, EP300, TP53, AKT1, KAT5
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.001	NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, DCC, BRAF, TLR4
Signalling by NGF (R-HSA-166520)	-	4.23	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, ODC1, EP300, BRAF, TLR4
Apoptotic cleavage of cellular proteins (R-HSA-111465)	-	7.73	0.008	APC, AKT1, CTNNB1, PTPN12
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.006	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, BRAF, TLR4
Toll Like Receptor 3 (TLR3) Cascade (R-HSA-168164)	NEW	6.47	0.029	TP53, CCND1, AKT1, TLR2, TLR4
Peptide hormone metabolism (R-HSA-2980736)	NEW	6.61	0.001	APC, BAX, AKT1, CCND1, TP53, CTNNB1, EP300
Toll-Like Receptors Cascades (R-HSA-168898)	-	5.91	0.035	CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.0	APC, AKT1, NRAS, PTPN12, CCND1, DLC1, TP53, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, BRAF, TLR2
Cell Cycle, Mitotic (R-HSA-69278)	-	4.16	0.001	APC, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, AKT1, KAT5, EP300, DLC1
Disease (R-HSA-1643685)	-	3.33	0.001	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, ODC1, TLR2
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.0	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, EP300, TLR4
Neuronal System (R-HSA-112316)	NEW	4.82	0.005	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1, DCC, BRAF
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.031	FGFR3, NRAS, AKT1, PIK3CA
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
TCF dependent signaling in response to WNT (R-HSA-201681)	-	5.36	0.006	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300, TLR4
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.002	APC, CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF
Toll Like Receptor TLR6:TLR2 Cascade (R-HSA-168188)	-	6.56	0.031	TP53, CCND1, AKT1, TLR2, TLR4
Signaling by FGFR (R-HSA-190236)	-	4.67	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.0	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, EP300
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.034	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.018	CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Innate Immune System (R-HSA-168249)	-	3.17	0.0	APC, BAX, CTNNB1, NRAS, EP300, CCND1, DLC1, TP53, FGFR3, ODC1, TLR4, PTPN12, PIK3CA, DCC, KAT5, AKT1, BRAF, TLR2
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.002	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.0	FGFR3, AKT1, NRAS, PIK3CA, CTNNB1
M Phase (R-HSA-68886)	NEW	4.87	0.048	APC, BUB1B, AURKA, TP53, PTPRJ, AKT1, KAT5
Signalling to RAS (R-HSA-167044)	-	5.08	0.002	CTNNB1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, BRAF
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (R-HSA-3134973)	-	10.66	0.03	EP300, CTNNB1
DAP12 signaling (R-HSA-2424491)	-	4.64	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.02	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MyD88-independent TLR3/TLR4 cascade (R-HSA-166166)	NEW	6.47	0.029	TP53, CCND1, TLR2, AKT1, TLR4
Signaling by EGFR (R-HSA-177929)	-	4.59	0.001	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, ODC1, EP300, BRAF, TLR4
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.014	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Apoptotic execution phase (R-HSA-75153)	-	7.28	0.026	APC, AKT1, PTPN12, CTNNB1
RHO GTPase Effectors (R-HSA-195258)	-	4.94	0.007	CTNNB1, AURKA, TP53, BUB1B, PIK3CA, TRIM28, AKT1, KAT5, EP300
Signaling by Wnt (R-HSA-195721)	-	4.79	0.024	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300, TLR4
formation of the beta-catenin:TCF transactivating complex (R-HSA-201722)	-	7.18	0.027	AXIN2, KAT5, EP300, CTNNB1
Signaling by GPCR (R-HSA-372790)	-	2.68	0.015	APC, BAX, AKT1, NRAS, CCND1, TP53, FGFR3, ODC1, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signalling to ERKs (R-HSA-187687)	-	5.04	0.0	APC, CTNNB1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, BRAF
Pre-NOTCH Transcription and Translation (R-HSA-1912408)	-	8.12	0.028	CCND1, EP300, TP53
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.013	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Signaling by VEGF (R-HSA-194138)	-	4.66	0.003	APC, CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF
DAP12 interactions (R-HSA-2172127)	-	4.56	0.001	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MyD88:Mal cascade initiated on plasma membrane (R-HSA-166058)	-	6.56	0.031	CCND1, TLR2, TP53, AKT1, TLR4
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179)	-	6.51	0.04	CCND1, TLR2, TP53, AKT1, TLR4
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.047	FGFR3, NRAS, PIK3CA
Hemostasis (R-HSA-109582)	-	3.98	0.001	APC, MT-CO1, AKT1, NRAS, AURKA, CCND1, BUB1B, TP53, PIK3CA, CTNNB1, KAT5, EP300, ODC1, TLR4
Apoptosis (R-HSA-109581)	-	5.68	0.0	APC, BAX, CTNNB1, CCND1, DLC1, TP53, TLR4, PTPN12, DCC, AKT1, TLR2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	29	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, MCC, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
protein binding (GO:0005515)	0.46	27	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, MCC, AXIN2, TRIM28, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
catalytic activity (GO:0003824)	1.05	18	PLA2G2A, MT-CO1, PTPN12, AURKA, PDGFRL, BUB1B, TRIM28, BRAF, FGFR3, ODC1, RAD54B, PTPRJ, PIK3CA, AKT1, KAT5, EP300, CCND1, MLH3
organic cyclic compound binding (GO:0097159)	1.05	14	MT-CO1, AKT1, NRAS, AURKA, TP53, BUB1B, TRIM28, FGFR3, RAD54B, PIK3CA, CTNNB1, EP300, BRAF, MLH3
heterocyclic compound binding (GO:1901363)	1.06	14	MT-CO1, AKT1, NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, TRIM28, PIK3CA, CTNNB1, EP300, MLH3
carbohydrate derivative binding (GO:0097367)	2.03	12	TLR2, NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, TLR4, MLH3
transferase activity (GO:0016740)	1.95	11	AURKA, PDGFRL, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, KAT5, EP300, CCND1
enzyme binding (GO:0019899)	2.27	11	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, TRIM28, AKT1, PTPRJ, EP300, BRAF
small molecule binding (GO:0036094)	1.89	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
nucleotide binding (GO:0000166)	1.96	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
protein kinase binding (GO:0019901)	3.44	10	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, PTPRJ, EP300, BRAF
kinase binding (GO:0019900)	3.32	10	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, PTPRJ, EP300, BRAF
macromolecular complex binding (GO:0044877)	2.61	10	APC, BAX, NRAS, CCND1, TRIM28, TP53, FLCN, CTNNB1, EP300, MLH3
ribonucleotide binding (GO:0032553)	2.19	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine nucleoside binding (GO:0001883)	2.22	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
ribonucleoside binding (GO:0032549)	2.22	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
purine ribonucleotide binding (GO:0032555)	2.2	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine nucleotide binding (GO:0017076)	2.19	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine ribonucleoside binding (GO:0032550)	2.22	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
nucleoside phosphate binding (GO:1901265)	1.96	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
nucleoside binding (GO:0001882)	2.21	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
adenyl nucleotide binding (GO:0030554)	2.4	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
kinase activity (GO:0016301)	2.93	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
adenyl ribonucleotide binding (GO:0032559)	2.41	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
protein kinase activity (GO:0004672)	3.27	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
ATP binding (GO:0005524)	2.43	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
molecular function regulator (GO:0098772)	2.51	8	APC, CCND1, PIK3CA, FGFR3, AXIN2, DLC1, AKT1, FLCN
ion binding (GO:0043167)	1.36	8	MT-CO1, PLA2G2A, TRIM28, TP53, AKT1, KAT5, EP300, BRAF
protein complex binding (GO:0032403)	3.09	7	APC, BAX, NRAS, CCND1, CTNNB1, EP300, FLCN
cation binding (GO:0043169)	1.4	7	MT-CO1, PLA2G2A, TP53, TRIM28, KAT5, EP300, BRAF
metal ion binding (GO:0046872)	1.41	7	MT-CO1, PLA2G2A, TP53, TRIM28, KAT5, EP300, BRAF
signal transducer activity (GO:0004871)	2.28	7	PDGFRL, FGFR3, TLR2, CTNNB1, DCC, BRAF, TLR4
enzyme regulator activity (GO:0030234)	2.85	6	APC, CCND1, PIK3CA, AXIN2, AKT1, DLC1
lipid binding (GO:0008289)	3.26	6	BAX, PLA2G2A, TLR2, AKT1, TLR4, DLC1
molecular transducer activity (GO:0060089)	2.32	6	PDGFRL, MCC, FGFR3, TLR4, DCC, TLR2
receptor activity (GO:0004872)	2.32	6	PDGFRL, MCC, FGFR3, TLR4, DCC, TLR2
nucleic acid binding (GO:0003676)	1.44	6	TP53, RAD54B, TRIM28, CTNNB1, EP300, MLH3
DNA binding (GO:0003677)	1.92	6	TP53, RAD54B, TRIM28, CTNNB1, EP300, MLH3
receptor binding (GO:0005102)	2.43	6	TP53, PTPRJ, CTNNB1, KAT5, EP300, TLR2
hydrolase activity (GO:0016787)	1.9	5	RAD54B, PLA2G2A, PTPRJ, MLH3, PTPN12
signaling receptor activity (GO:0038023)	2.49	5	DCC, FGFR3, PDGFRL, TLR4, TLR2
transcription factor binding (GO:0008134)	3.46	5	CCND1, EP300, TP53, CTNNB1, KAT5
transcription cofactor activity (GO:0003712)	3.44	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
protein serine/threonine kinase activity (GO:0004674)	3.64	5	BUB1B, BRAF, AURKA, PIK3CA, AKT1
transmembrane signaling receptor activity (GO:0004888)	2.57	5	FGFR3, DCC, PDGFRL, TLR4, TLR2
identical protein binding (GO:0042802)	2.63	5	ODC1, BAX, TP53, AKT1, BRAF
protein domain specific binding (GO:0019904)	3.32	5	PTPN12, BAX, AXIN2, DLC1, TRIM28
transcription factor activity, transcription factor binding (GO:0000989)	3.36	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
transcription factor activity, protein binding (GO:0000988)	3.35	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
protein dimerization activity (GO:0046983)	2.72	5	ODC1, BAX, TP53, TLR2, BRAF
chromatin binding (GO:0003682)	3.64	5	MLH3, TP53, EP300, TRIM28, CTNNB1
transmembrane receptor activity (GO:0099600)	2.53	5	DCC, FGFR3, PDGFRL, TLR2, TLR4
sequence-specific DNA binding (GO:0043565)	2.79	4	TP53, EP300, MLH3, TRIM28
ubiquitin protein ligase binding (GO:0031625)	4.17	4	AURKA, AXIN2, TRIM28, TP53
ubiquitin-like protein ligase binding (GO:0044389)	4.15	4	AXIN2, AURKA, TRIM28, TP53
transition metal ion binding (GO:0046914)	2.48	4	MT-CO1, EP300, TP53, TRIM28
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	4	TRIM28, EP300, TP53, CTNNB1
transcription coactivator activity (GO:0003713)	4.04	4	KAT5, EP300, TRIM28, CTNNB1
beta-catenin binding (GO:0008013)	5.3	4	APC, PTPRJ, EP300, AXIN2
nucleic acid binding transcription factor activity (GO:0001071)	2.65	4	TP53, EP300, TRIM28, CTNNB1
double-stranded DNA binding (GO:0003690)	3.09	4	TP53, EP300, MLH3, CTNNB1
protein heterodimerization activity (GO:0046982)	3.64	4	BRAF, BAX, TP53, TLR2
RNA polymerase II transcription factor binding (GO:0001085)	5.08	3	EP300, TP53, CTNNB1
transcription regulatory region DNA binding (GO:0044212)	3.03	3	EP300, TP53, CTNNB1
steroid hormone receptor binding (GO:0035258)	5.32	3	KAT5, EP300, CTNNB1
kinase regulator activity (GO:0019207)	4.5	3	APC, CCND1, PIK3CA
protein kinase regulator activity (GO:0019887)	4.6	3	APC, CCND1, PIK3CA
nuclear hormone receptor binding (GO:0035257)	4.7	3	KAT5, EP300, CTNNB1
regulatory region nucleic acid binding (GO:0001067)	3.03	3	EP300, TP53, CTNNB1
androgen receptor binding (GO:0050681)	6.07	3	KAT5, EP300, CTNNB1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PLA2G2A, PTPRJ, PTPN12
SMAD binding (GO:0046332)	5.45	3	AXIN2, EP300, CTNNB1
protein phosphatase binding (GO:0019903)	4.93	3	TP53, AKT1, CTNNB1
phosphatase binding (GO:0019902)	4.63	3	TP53, AKT1, CTNNB1
zinc ion binding (GO:0008270)	2.66	3	EP300, TP53, TRIM28
regulatory region DNA binding (GO:0000975)	3.03	3	EP300, TP53, CTNNB1
hormone receptor binding (GO:0051427)	4.57	3	KAT5, EP300, CTNNB1
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	3	EP300, MLH3, TP53
enzyme activator activity (GO:0008047)	3.56	3	AXIN2, DLC1, PIK3CA
protein C-terminus binding (GO:0008022)	4.5	2	EP300, CTNNB1
transcription corepressor activity (GO:0003714)	4.33	2	CCND1, TRIM28
phosphatase activity (GO:0016791)	4.11	2	PTPRJ, PTPN12
peptide N-acetyltransferase activity (GO:0034212)	5.55	2	KAT5, EP300
activating transcription factor binding (GO:0033613)	5.68	2	EP300, CTNNB1
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	FGFR3, FLCN
peptide-lysine-N-acetyltransferase activity (GO:0061733)	5.68	2	KAT5, EP300
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	EP300, TP53
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	PTPRJ, PTPN12
pattern recognition receptor activity (GO:0038187)	6.91	2	TLR4, TLR2
cadherin binding (GO:0045296)	6.41	2	APC, CTNNB1
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	FGFR3, PIK3CA
repressing transcription factor binding (GO:0070491)	5.71	2	KAT5, CTNNB1
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	2	FGFR3, PIK3CA
N-acetyltransferase activity (GO:0008080)	5.27	2	KAT5, EP300
phospholipid binding (GO:0005543)	3.91	2	PLA2G2A, AKT1
histone acetyltransferase activity (GO:0004402)	5.7	2	KAT5, EP300
transmembrane transporter activity (GO:0022857)	2.82	2	MT-CO1, BAX
chaperone binding (GO:0051087)	5.34	2	BAX, TP53
transporter activity (GO:0005215)	2.57	2	MT-CO1, BAX
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	2	FGFR3, PIK3CA
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	FGFR3, PDGFRL
transferase activity, transferring acyl groups (GO:0016746)	4.2	2	KAT5, EP300
protein tyrosine kinase activity (GO:0004713)	4.54	2	FGFR3, PDGFRL
N-acyltransferase activity (GO:0016410)	5.08	2	KAT5, EP300
I-SMAD binding (GO:0070411)	7.34	2	AXIN2, CTNNB1
protein serine/threonine/tyrosine kinase activity (GO:0004712)	6.07	2	AURKA, AKT1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	EP300, TP53
calcium ion binding (GO:0005509)	3.17	2	PLA2G2A, BRAF
mitogen-activated protein kinase binding (GO:0051019)	6.56	2	PTPRJ, EP300
signaling pattern recognition receptor activity (GO:0008329)	6.91	2	TLR4, TLR2
gamma-catenin binding (GO:0045295)	7.17	2	APC, PTPRJ
1-phosphatidylinositol-3-kinase activity (GO:0016303)	5.98	2	FGFR3, PIK3CA
GTPase activator activity (GO:0005096)	4.11	2	AXIN2, DLC1
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747)	4.37	2	KAT5, EP300
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	RAD54B, MLH3
GTPase regulator activity (GO:0030695)	4.01	2	AXIN2, DLC1
RNA polymerase II activating transcription factor binding (GO:0001102)	6.13	2	EP300, CTNNB1
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	EP300, TP53
cell adhesion molecule binding (GO:0050839)	4.5	2	APC, CTNNB1
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	2	AXIN2, DLC1
lipopolysaccharide binding (GO:0001530)	6.69	2	TLR4, TLR2
protein phosphatase 2A binding (GO:0051721)	6.41	2	TP53, AKT1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	RAD54B, MLH3
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	FGFR3, PDGFRL
phosphatidylinositol kinase activity (GO:0052742)	5.81	2	FGFR3, PIK3CA
protein tyrosine phosphatase activity (GO:0004725)	5.09	2	PTPRJ, PTPN12
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	RAD54B, MLH3
phosphoprotein phosphatase activity (GO:0004721)	4.55	2	PTPRJ, PTPN12
pyrophosphatase activity (GO:0016462)	3.04	2	RAD54B, MLH3
acetyltransferase activity (GO:0016407)	5.1	2	KAT5, EP300
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	EP300, TP53
RNA binding (GO:0003723)	2.36	2	EP300, TRIM28
core promoter binding (GO:0001047)	4.71	2	EP300, TP53
lipopolysaccharide receptor activity (GO:0001875)	8.13	2	TLR4, TLR2
protein homodimerization activity (GO:0042803)	3.16	2	ODC1, BAX
p53 binding (GO:0002039)	5.53	2	EP300, TP53
damaged DNA binding (GO:0003684)	5.58	2	EP300, TP53
ATPase activity (GO:0016887)	3.65	2	RAD54B, MLH3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
androgen receptor binding (GO:0050681)	-	6.07	0.002	KAT5, EP300, AKT1, CTNNB1
molecular transducer activity (GO:0060089)	-	2.32	0.0	CTNNB1, NRAS, PTPN12, PDGFRL, DLC1, TRIM28, BRAF, FGFR3, TP53, PTPRJ, PIK3CA, AKT1, TLR4, DCC, ODC1, CCND1, EP300, KAT5, TLR2
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076)	NEW	4.84	0.007	BAX, AKT1, TP53, CTNNB1, KAT5, EP300
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	NEW	4.31	0.006	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, TLR4
zinc ion binding (GO:0008270)	-	2.66	0.0	APC, BAX, AURKA, AKT1, PTPN12, MLH3, CCND1, BUB1B, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
hormone receptor binding (GO:0051427)	-	4.57	0.028	CTNNB1, TP53, AKT1, KAT5, EP300, TLR4
transcription corepressor activity (GO:0003714)	-	4.33	0.0	BAX, CTNNB1, CCND1, AURKA, TRIM28, TP53, AKT1, KAT5, EP300
transcription coactivator activity (GO:0003713)	-	4.04	0.025	AKT1, CCND1, AURKA, TRIM28, TP53, CTNNB1, DCC, KAT5, EP300
transcription cofactor activity (GO:0003712)	-	3.44	0.0	BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, AXIN2, TP53, CTNNB1, DCC, KAT5, EP300, ODC1, TLR4
heparin binding (GO:0008201)	NEW	4.68	0.007	AKT1, CCND1, TP53, CTNNB1, DCC, KAT5, FLCN
transferase activity (GO:0016740)	-	1.95	0.0	MT-CO1, PTPN12, BUB1B, PDGFRL, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, AXIN2, AKT1, EP300, DLC1, AURKA, FGFR3, ODC1, BRAF, MLH3
protein serine/threonine/tyrosine kinase activity (GO:0004712)	-	6.07	0.01	CCND1, AURKA, TP53, AKT1
cytokine receptor activity (GO:0004896)	NEW	5.24	0.02	PTPRJ, AKT1, EP300, PIK3CA, TLR2
I-SMAD binding (GO:0070411)	-	7.34	0.035	AXIN2, CTNNB1
GTPase activator activity (GO:0005096)	-	4.11	0.004	APC, CTNNB1, DLC1, PIK3CA, AXIN2, TP53, AKT1, TLR4
SMAD binding (GO:0046332)	-	5.45	0.002	AXIN2, TP53, EP300, AKT1, CTNNB1
kinase binding (GO:0019900)	-	3.32	0.0	APC, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, BRAF, AXIN2, TP53, CTNNB1, DCC, PTPRJ, KAT5, EP300, ODC1, TLR4
protein domain specific binding (GO:0019904)	-	3.32	0.0	APC, BAX, PIK3CA, CTNNB1, DLC1, EP300, CCND1, AURKA, TP53, AXIN2, TRIM28, PTPN12, TLR4, DCC, PTPRJ, AKT1, TLR2
purine nucleotide binding (GO:0017076)	-	2.19	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.001	AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
carbohydrate derivative binding (GO:0097367)	-	2.03	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1, MLH3
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.001	AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
receptor signaling protein serine/threonine kinase activity (GO:0004702)	NEW	5.23	0.002	TP53, TLR2, AKT1, CTNNB1, BRAF
GTP binding (GO:0005525)	NEW	3.78	0.002	NRAS, CCND1, AURKA, PIK3CA, TRIM28, AKT1, DCC, EP300, BRAF, TLR2
cytokine receptor binding (GO:0005126)	NEW	4.14	0.006	BAX, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300, TLR4
RNA polymerase II regulatory region DNA binding (GO:0001012)	NEW	3.36	0.043	CTNNB1, CCND1, BUB1B, TP53, AKT1, KAT5, EP300, TLR4
core promoter proximal region DNA binding (GO:0001159)	NEW	3.82	0.015	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, TLR4
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.006	TP53, CCND1, EP300, CTNNB1, AKT1
signaling receptor activity (GO:0038023)	-	2.49	0.0	AKT1, NRAS, PTPN12, PDGFRL, TRIM28, FGFR3, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, CCND1, EP300, KAT5, TLR2
growth factor activity (GO:0008083)	NEW	4.66	0.007	AKT1, CCND1, TP53, FGFR3, CTNNB1, KAT5, EP300
transition metal ion binding (GO:0046914)	-	2.48	0.0	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, DCC, TLR4, BAX, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, CCND1, MLH3
cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028)	NEW	6.02	0.0	TP53, AURKA, AKT1, CTNNB1, BAX
transcription factor binding transcription factor activity (GO:0000989)	-	3.36	0.0	BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, AXIN2, TP53, CTNNB1, DCC, KAT5, EP300, ODC1, TLR4
protein binding transcription factor activity (GO:0000988)	-	3.35	0.0	BAX, AKT1, DLC1, CCND1, AURKA, TP53, AXIN2, TRIM28, CTNNB1, DCC, KAT5, EP300, ODC1, TLR4
core promoter proximal region sequence-specific DNA binding (GO:0000987)	NEW	3.83	0.015	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, TLR4
passive transmembrane transporter activity (GO:0022803)	NEW	3.6	0.002	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1, EP300, BRAF, DLC1
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982)	NEW	3.94	0.049	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, TLR4
ATP binding (GO:0005524)	-	2.43	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980)	NEW	5.58	0.001	AKT1, CCND1, EP300, TP53, CTNNB1
sulfur compound binding (GO:1901681)	NEW	4.32	0.007	BAX, AKT1, CCND1, TP53, CTNNB1, DCC, KAT5, FLCN
steroid hormone receptor binding (GO:0035258)	-	5.32	0.003	TP53, EP300, AKT1, CTNNB1, KAT5
protein kinase regulator activity (GO:0019887)	-	4.6	0.015	APC, CCND1, PIK3CA, TP53, AKT1, ODC1
nucleotide binding (GO:0000166)	-	1.96	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
microtubule binding (GO:0008017)	NEW	4.42	0.0	APC, CTNNB1, AURKA, CCND1, BUB1B, TP53, AKT1, KAT5, TLR4
kinase activity (GO:0016301)	-	2.93	0.003	BAX, AURKA, AKT1, PTPN12, MLH3, CCND1, BUB1B, TP53, BRAF, FGFR3, TRIM28, PIK3CA, CTNNB1, DLC1, DCC, KAT5, EP300, PDGFRL, TLR2
hydrolase activity, acting on ester bonds (GO:0016788)	-	3.1	0.0	BAX, TLR2, AKT1, PTPN12, AURKA, CCND1, PLA2G2A, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DLC1, KAT5, EP300, ODC1, MLH3
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.0	AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
beta-catenin binding (GO:0008013)	-	5.3	0.001	APC, CTNNB1, AXIN2, AKT1, PTPRJ, EP300
ubiquitin-protein transferase activity (GO:0004842)	NEW	3.73	0.002	BAX, CCND1, TRIM28, TP53, AKT1, EP300, BRAF, TLR4
cytoskeletal protein binding (GO:0008092)	NEW	3.02	0.015	APC, CTNNB1, EP300, AURKA, CCND1, BUB1B, TP53, DLC1, PTPN12, DCC, KAT5, AKT1, TLR4
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.0	AKT1, PTPN12, AURKA, CCND1, BUB1B, TP53, BRAF, FGFR3, TRIM28, PIK3CA, CTNNB1, DLC1, DCC, KAT5, EP300, PDGFRL, TLR2
transferase activity, transferring phosphorus-containing groups (GO:0016772)	-	2.77	0.013	BAX, AURKA, CTNNB1, DLC1, EP300, CCND1, BUB1B, TP53, BRAF, FGFR3, TRIM28, TLR2, PTPN12, PIK3CA, DCC, KAT5, AKT1, PDGFRL, MLH3
protein tyrosine phosphatase activity (GO:0004725)	-	5.09	0.0	AKT1, PTPN12, TP53, PTPRJ, CTNNB1, EP300, TLR4
phosphoprotein phosphatase activity (GO:0004721)	-	4.55	0.0	AKT1, PTPN12, AURKA, TP53, PTPRJ, CTNNB1, EP300, TLR4
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.0	CTNNB1, CCND1, AURKA, TP53, TLR2, AKT1, DCC, KAT5, FLCN
pyrophosphatase activity (GO:0016462)	-	3.04	0.001	AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
channel activity (GO:0015267)	NEW	3.6	0.002	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1, EP300, BRAF, DLC1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.015	AKT1, CCND1, BUB1B, TP53, CTNNB1, DCC, KAT5, EP300, TLR4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	NEW	3.37	0.041	CTNNB1, CCND1, BUB1B, TP53, AKT1, KAT5, EP300, TLR4
purine ribonucleotide binding (GO:0032555)	-	2.2	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
lipopolysaccharide receptor activity (GO:0001875)	-	8.13	0.006	TLR4, TLR2
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	NEW	3.88	0.012	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, TLR4
protein heterodimerization activity (GO:0046982)	-	3.64	0.01	BAX, AKT1, CCND1, TRIM28, TP53, TLR4, CTNNB1, KAT5, EP300, BRAF, TLR2
purine ribonucleoside binding (GO:0032550)	-	2.22	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
ribonucleotide binding (GO:0032553)	-	2.19	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
phosphatase activity (GO:0016791)	-	4.11	0.001	AKT1, PTPN12, DLC1, TP53, PTPRJ, TLR4, CTNNB1, EP300, MLH3
activating transcription factor binding (GO:0033613)	-	5.68	0.024	CCND1, EP300, TP53, CTNNB1
enzyme binding (GO:0019899)	-	2.27	0.0	APC, BAX, AURKA, PIK3CA, PTPN12, DLC1, EP300, CCND1, BUB1B, TP53, ODC1, AXIN2, TRIM28, CTNNB1, TLR4, DCC, PTPRJ, KAT5, AKT1, BRAF, TLR2
phosphoric ester hydrolase activity (GO:0042578)	-	3.82	0.0	BAX, CTNNB1, EP300, DLC1, TP53, PTPRJ, TLR4, PTPN12, KAT5, AKT1, ODC1, MLH3
chromatin DNA binding (GO:0031490)	NEW	5.37	0.001	CCND1, EP300, TP53, CTNNB1, KAT5
G-protein coupled receptor binding (GO:0001664)	NEW	4.18	0.001	BAX, AKT1, CCND1, PIK3CA, TP53, CTNNB1, KAT5, EP300, TLR4
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.0	APC, BAX, AKT1, CCND1, AURKA, PIK3CA, TP53, CTNNB1, DCC, KAT5, EP300, ODC1, TLR4
guanyl nucleotide binding (GO:0019001)	NEW	3.73	0.005	NRAS, CCND1, AURKA, PIK3CA, TRIM28, TP53, AKT1, DCC, BRAF, TLR2
anion binding (GO:0043168)	NEW	4.17	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
sequence-specific DNA binding (GO:0043565)	-	2.79	0.0	APC, AKT1, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, TLR4, DCC, KAT5, EP300, TRIM28, MLH3
structure-specific DNA binding (GO:0043566)	NEW	4.98	0.001	APC, AKT1, CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, MLH3
ribonucleoside binding (GO:0032549)	-	2.22	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
guanyl ribonucleotide binding (GO:0032561)	NEW	3.73	0.005	NRAS, CCND1, AURKA, PIK3CA, TRIM28, TP53, AKT1, DCC, BRAF, TLR2
calcium ion binding (GO:0005509)	-	3.17	0.0	APC, AKT1, PTPN12, PLA2G2A, AURKA, TP53, BRAF, FGFR3, PTPRJ, PIK3CA, CTNNB1, DLC1, DCC, KAT5, CCND1, TLR4
protein complex binding (GO:0032403)	-	3.09	0.0	APC, TLR2, AKT1, NRAS, PTPN12, AURKA, CCND1, BUB1B, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DLC1, KAT5, EP300, BRAF, FLCN
double-stranded DNA binding (GO:0003690)	-	3.09	0.0	APC, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300, MLH3
protein homodimerization activity (GO:0042803)	-	3.16	0.02	BAX, AKT1, CCND1, TRIM28, ODC1, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
lipid binding (GO:0008289)	-	3.26	0.019	BAX, TLR2, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, KAT5, EP300, PLA2G2A, TLR4
histone acetyltransferase binding (GO:0035035)	NEW	6.41	0.015	KAT5, EP300, TP53
enhancer binding (GO:0035326)	NEW	5.21	0.017	TP53, CCND1, EP300, CTNNB1, AKT1
RNA polymerase II activating transcription factor binding (GO:0001102)	-	6.13	0.007	CCND1, EP300, TP53, CTNNB1
cysteine-type endopeptidase inhibitor activity (GO:0004869)	NEW	5.71	0.042	AURKA, EP300, TP53, AKT1
nucleoside-triphosphatase regulator activity (GO:0060589)	-	3.92	0.049	APC, CTNNB1, DLC1, PIK3CA, AXIN2, TP53, AKT1, TLR4
iron ion binding (GO:0005506)	NEW	4.65	0.0	MT-CO1, AKT1, BRAF, TP53, CTNNB1, KAT5, EP300, PLA2G2A
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.0	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, TRIM28, AKT1, ODC1
adenyl nucleotide binding (GO:0030554)	-	2.4	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
gamma-catenin binding (GO:0045295)	-	7.17	0.042	APC, PTPRJ, CTNNB1
calmodulin binding (GO:0005516)	NEW	4.55	0.036	AKT1, CCND1, PIK3CA, TP53, CTNNB1, BRAF
protein binding (GO:0005515)	-	0.46	0.0	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, MCC, AXIN2, TRIM28, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
receptor binding (GO:0005102)	-	2.43	0.001	BAX, AKT1, NRAS, PTPN12, CCND1, AURKA, TP53, FGFR3, TLR4, AXIN2, TLR2, CTNNB1, PIK3CA, DCC, PTPRJ, KAT5, EP300, FLCN
chromatin binding (GO:0003682)	-	3.64	0.007	AKT1, AURKA, CCND1, BUB1B, TP53, CTNNB1, DCC, KAT5, EP300, MLH3
receptor activity (GO:0004872)	-	2.32	0.0	AKT1, NRAS, PTPN12, EP300, PDGFRL, DLC1, TRIM28, FGFR3, ODC1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, MCC, CCND1, TLR2
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.0	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, TRIM28, AKT1, ODC1
kinase regulator activity (GO:0019207)	-	4.5	0.039	APC, CCND1, PIK3CA, TP53, AKT1, ODC1
SH3 domain binding (GO:0017124)	NEW	4.98	0.011	BAX, PTPN12, TP53, AKT1, DCC, EP300
enzyme activator activity (GO:0008047)	-	3.56	0.0	APC, AKT1, CCND1, DLC1, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, ODC1, BRAF, TLR2
signal transducer activity (GO:0004871)	-	2.28	0.0	AKT1, NRAS, PTPN12, PDGFRL, DLC1, TRIM28, BRAF, FGFR3, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, CCND1, EP300, KAT5, TLR2
purine nucleoside binding (GO:0001883)	-	2.22	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
nucleoside binding (GO:0001882)	-	2.21	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
mitogen-activated protein kinase kinase binding (GO:0031434)	NEW	6.97	0.005	BRAF, TP53, AKT1
receptor signaling protein activity (GO:0005057)	NEW	4.76	0.001	CTNNB1, BRAF, TP53, FGFR3, PIK3CA, AKT1, TLR2
protein serine/threonine kinase activity (GO:0004674)	-	3.64	0.0	AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, PIK3CA, CTNNB1, DCC, KAT5, EP300, BRAF, TLR2
organic cation transmembrane transporter activity (GO:0015101)	NEW	7.34	0.048	CCND1, ODC1, TP53
nucleoside phosphate binding (GO:1901265)	-	1.96	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
protein kinase activity (GO:0004672)	-	3.27	0.0	CTNNB1, EP300, AURKA, CCND1, BUB1B, TP53, BRAF, FGFR3, TRIM28, PIK3CA, PTPN12, DLC1, DCC, KAT5, AKT1, PDGFRL, TLR2
repressing transcription factor binding (GO:0070491)	-	5.71	0.001	CCND1, EP300, TP53, CTNNB1, KAT5
tubulin binding (GO:0015631)	NEW	4.1	0.0	APC, CTNNB1, AURKA, CCND1, BUB1B, TP53, DLC1, AKT1, KAT5, EP300, TLR4
peptidase regulator activity (GO:0061134)	NEW	4.37	0.004	APC, BAX, CCND1, AURKA, TP53, AKT1, BRAF, TLR2
LBD domain binding (GO:0050693)	NEW	8.35	0.038	EP300, TP53
protein kinase binding (GO:0019901)	-	3.44	0.0	APC, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, ODC1, AXIN2, TP53, CTNNB1, DCC, PTPRJ, KAT5, EP300, BRAF, TLR4
growth factor receptor binding (GO:0070851)	NEW	4.87	0.005	AURKA, PIK3CA, FGFR3, PTPRJ, AKT1, TLR4
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705)	NEW	5.23	0.05	TP53, CCND1, EP300, CTNNB1, AKT1
transmembrane signaling receptor activity (GO:0004888)	-	2.57	0.003	CTNNB1, EP300, CCND1, TP53, FGFR3, ODC1, PTPRJ, TLR4, PTPN12, PIK3CA, DCC, KAT5, AKT1, PDGFRL, TLR2
GTPase regulator activity (GO:0030695)	-	4.01	0.024	APC, CTNNB1, DLC1, PIK3CA, AXIN2, TP53, AKT1, TLR4
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	-	3.98	0.005	CTNNB1, CCND1, BUB1B, TP53, AKT1, KAT5, EP300, TLR4

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	28	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
biological regulation (GO:0065007)	0.39	26	BUB1B, PDGFRL, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
regulation of biological process (GO:0050789)	0.45	26	BUB1B, PDGFRL, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
single-organism process (GO:0044699)	0.48	26	MT-CO1, AKT1, BUB1B, TP53, RAD54B, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
regulation of cellular process (GO:0050794)	0.5	26	BUB1B, PDGFRL, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
organic substance metabolic process (GO:0071704)	0.63	25	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
cellular metabolic process (GO:0044237)	0.69	25	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
metabolic process (GO:0008152)	0.58	25	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
primary metabolic process (GO:0044238)	0.69	25	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
single-organism cellular process (GO:0044763)	0.65	24	MT-CO1, BUB1B, TP53, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
positive regulation of biological process (GO:0048518)	1.2	23	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
signal transduction (GO:0007165)	1.28	23	PDGFRL, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, CCND1
regulation of primary metabolic process (GO:0080090)	1.08	22	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of metabolic process (GO:0019222)	1.02	22	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of macromolecule metabolic process (GO:0060255)	1.08	22	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of cellular metabolic process (GO:0031323)	1.07	22	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of response to stimulus (GO:0048583)	1.54	22	TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, CCND1
positive regulation of cellular process (GO:0048522)	1.3	22	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, FLCN, BAX, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of biological process (GO:0048519)	1.33	21	APC, FGFR3, BAX, AKT1, EP300, AURKA, CCND1, BUB1B, TRIM28, DLC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, MCC, BRAF, FLCN
cellular macromolecule metabolic process (GO:0044260)	0.93	21	APC, AURKA, TLR2, PTPN12, NRAS, EP300, CCND1, BUB1B, TP53, FGFR3, RAD54B, AXIN2, TRIM28, CTNNB1, TLR4, PTPRJ, KAT5, AKT1, BRAF, MLH3, PIK3CA
macromolecule metabolic process (GO:0043170)	0.83	21	APC, TP53, PIK3CA, CTNNB1, NRAS, EP300, AURKA, CCND1, BUB1B, TRIM28, FGFR3, RAD54B, AXIN2, TLR2, PTPN12, TLR4, PTPRJ, KAT5, AKT1, BRAF, MLH3
developmental process (GO:0032502)	1.36	20	APC, MT-CO1, CTNNB1, DLC1, EP300, CCND1, AURKA, BAX, TRIM28, FGFR3, TP53, AXIN2, TLR4, PTPN12, PIK3CA, DCC, ODC1, AKT1, BRAF, FLCN
multicellular organismal process (GO:0032501)	1.45	20	APC, BAX, TLR2, AKT1, AURKA, CCND1, TRIM28, TP53, BRAF, FGFR3, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, EP300, PLA2G2A, FLCN
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	20	APC, BAX, TLR2, CTNNB1, DLC1, AURKA, PLA2G2A, BUB1B, TRIM28, BRAF, FGFR3, TP53, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, FLCN
regulation of signal transduction (GO:0009966)	1.84	20	APC, BAX, TLR2, CTNNB1, DLC1, EP300, PLA2G2A, AURKA, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, KAT5, MCC, CCND1, FLCN
response to stimulus (GO:0050896)	1.22	20	APC, MT-CO1, TLR2, AKT1, CCND1, AURKA, BAX, TP53, BRAF, TLR4, RAD54B, AXIN2, TRIM28, CTNNB1, PIK3CA, ODC1, KAT5, EP300, PLA2G2A, MLH3
regulation of protein metabolic process (GO:0051246)	1.93	20	APC, BAX, CTNNB1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, ODC1, PTPRJ, TP53, AKT1, TLR4, AXIN2, KAT5, EP300, PLA2G2A, FLCN
single-organism developmental process (GO:0044767)	1.49	20	APC, MT-CO1, AURKA, PIK3CA, CTNNB1, EP300, CCND1, DLC1, BAX, TP53, FGFR3, AXIN2, TRIM28, PTPN12, TLR4, DCC, ODC1, AKT1, BRAF, FLCN
regulation of signaling (GO:0023051)	1.72	20	APC, PLA2G2A, BAX, TLR2, CTNNB1, DLC1, EP300, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, KAT5, MCC, BRAF, FLCN
regulation of cell communication (GO:0010646)	1.73	20	APC, BAX, TLR2, CTNNB1, DLC1, EP300, PLA2G2A, AURKA, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, KAT5, MCC, CCND1, FLCN
negative regulation of cellular process (GO:0048523)	1.41	20	APC, BAX, AURKA, AKT1, DLC1, EP300, CCND1, BUB1B, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, DCC, PTPRJ, KAT5, MCC, BRAF, FLCN
positive regulation of metabolic process (GO:0009893)	1.74	20	APC, BAX, TLR2, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, BRAF, FGFR3, TP53, AXIN2, TLR4, CTNNB1, PIK3CA, KAT5, EP300, PLA2G2A, FLCN
regulation of cellular protein metabolic process (GO:0032268)	1.99	19	APC, BAX, AKT1, DLC1, AURKA, PLA2G2A, BUB1B, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, CCND1, FLCN
single-multicellular organism process (GO:0044707)	1.78	19	APC, FGFR3, BAX, CTNNB1, CCND1, AURKA, TRIM28, BRAF, TP53, TLR4, RAD54B, AXIN2, TLR2, AKT1, PIK3CA, DCC, EP300, PLA2G2A, FLCN
positive regulation of cellular metabolic process (GO:0031325)	1.81	19	BAX, TLR2, CTNNB1, DLC1, AURKA, PLA2G2A, BUB1B, TRIM28, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, FLCN
anatomical structure development (GO:0048856)	1.58	19	APC, MT-CO1, CTNNB1, DLC1, EP300, CCND1, TRIM28, BAX, TP53, FGFR3, AXIN2, TLR4, PTPN12, PIK3CA, DCC, ODC1, AKT1, BRAF, FLCN
cellular component organization (GO:0016043)	1.24	19	APC, BAX, AURKA, AKT1, DLC1, MLH3, PLA2G2A, BUB1B, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, DCC, KAT5, EP300, BRAF, FLCN
cellular component organization or biogenesis (GO:0071840)	1.22	19	APC, BAX, AURKA, CTNNB1, DLC1, MLH3, PLA2G2A, BUB1B, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, AKT1, DCC, KAT5, EP300, BRAF, FLCN
protein metabolic process (GO:0019538)	1.45	18	APC, AKT1, NRAS, PTPN12, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, PTPRJ, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, BRAF, TLR2
regulation of molecular function (GO:0065009)	1.78	18	APC, BAX, TLR2, CTNNB1, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, EP300, BRAF, FLCN
positive regulation of protein metabolic process (GO:0051247)	2.43	18	APC, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, PLA2G2A, FLCN
regulation of protein modification process (GO:0031399)	2.32	18	APC, BAX, AKT1, DLC1, CCND1, BUB1B, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, PLA2G2A, FLCN
cellular response to stimulus (GO:0051716)	1.97	17	APC, BAX, AURKA, AKT1, MLH3, CCND1, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	17	BAX, AKT1, DLC1, AURKA, PLA2G2A, BUB1B, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, CCND1, FLCN
positive regulation of response to stimulus (GO:0048584)	2.18	16	BAX, TLR2, AKT1, NRAS, PLA2G2A, TP53, FGFR3, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, PTPRJ, EP300, BRAF, FLCN
cellular protein metabolic process (GO:0044267)	1.63	16	AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, TP53, PTPRJ, TLR4, PTPN12, PIK3CA, KAT5, EP300, BRAF, TLR2
positive regulation of protein modification process (GO:0031401)	2.7	16	PLA2G2A, BAX, AKT1, DLC1, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, FLCN
regulation of phosphate metabolic process (GO:0019220)	2.35	16	APC, BAX, CTNNB1, CCND1, DLC1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, EP300, PLA2G2A, FLCN
regulation of catalytic activity (GO:0050790)	1.97	16	APC, BAX, AKT1, DLC1, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, FLCN
cellular protein modification process (GO:0006464)	1.79	16	AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, TP53, PTPRJ, TLR4, PTPN12, PIK3CA, KAT5, EP300, BRAF, TLR2
regulation of cellular component organization (GO:0051128)	2.01	16	APC, BAX, AKT1, DLC1, AURKA, BRAF, BUB1B, TP53, AXIN2, TLR4, CTNNB1, DCC, PTPRJ, EP300, TRIM28, FLCN
regulation of phosphorus metabolic process (GO:0051174)	2.35	16	APC, BAX, CTNNB1, CCND1, DLC1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, EP300, PLA2G2A, FLCN
macromolecule modification (GO:0043412)	1.73	16	PTPN12, NRAS, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, PTPRJ, TRIM28, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
protein modification process (GO:0036211)	1.79	16	AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, TP53, PTPRJ, TLR4, PTPN12, PIK3CA, KAT5, EP300, BRAF, TLR2
cell surface receptor signaling pathway (GO:0007166)	2.09	16	APC, BAX, AKT1, NRAS, PDGFRL, MCC, FGFR3, AXIN2, TLR4, CTNNB1, PIK3CA, DCC, PTPRJ, EP300, CCND1, TLR2
response to chemical (GO:0042221)	1.98	16	APC, MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
regulation of intracellular signal transduction (GO:1902531)	2.31	16	BAX, TLR2, CTNNB1, AURKA, PLA2G2A, DLC1, TP53, FGFR3, PTPRJ, PIK3CA, AKT1, TLR4, KAT5, EP300, BRAF, FLCN
localization (GO:0051179)	1.4	16	MT-CO1, TLR2, CTNNB1, NRAS, AURKA, CCND1, BUB1B, BAX, TP53, AXIN2, PIK3CA, AKT1, TLR4, MCC, BRAF, MLH3
regulation of phosphorylation (GO:0042325)	2.5	15	APC, BAX, CTNNB1, CCND1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, PTPRJ, EP300, PLA2G2A, FLCN
regulation of cell proliferation (GO:0042127)	2.41	15	APC, BAX, AKT1, CCND1, DLC1, MCC, FGFR3, AXIN2, TP53, CTNNB1, TLR4, PTPRJ, ODC1, BRAF, FLCN
regulation of protein phosphorylation (GO:0001932)	2.57	15	APC, BAX, AKT1, CCND1, PLA2G2A, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, FLCN
response to stress (GO:0006950)	1.8	15	APC, MT-CO1, MLH3, CCND1, AURKA, BAX, TP53, RAD54B, TRIM28, AKT1, TLR4, KAT5, EP300, PLA2G2A, TLR2
phosphate-containing compound metabolic process (GO:0006796)	2.16	15	MT-CO1, PTPN12, NRAS, AURKA, CCND1, BUB1B, TRIM28, BRAF, FGFR3, PTPRJ, PIK3CA, AKT1, TLR4, PLA2G2A, TLR2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	15	APC, BAX, AKT1, CCND1, TRIM28, TLR4, TP53, AXIN2, FLCN, CTNNB1, PIK3CA, KAT5, EP300, ODC1, TLR2
regulation of multicellular organismal process (GO:0051239)	1.87	15	BAX, TLR2, AKT1, CCND1, AURKA, MCC, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
phosphorus metabolic process (GO:0006793)	2.15	15	MT-CO1, TLR2, AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, BRAF, FGFR3, PTPRJ, PIK3CA, PTPN12, PLA2G2A, TLR4
regulation of localization (GO:0032879)	1.94	15	APC, BAX, TLR2, AKT1, DLC1, BRAF, TRIM28, TP53, AXIN2, MCC, CTNNB1, TLR4, PTPRJ, EP300, FLCN
positive regulation of phosphate metabolic process (GO:0045937)	2.78	14	BAX, AKT1, PLA2G2A, DLC1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, EP300, CCND1, FLCN
regulation of developmental process (GO:0050793)	2.1	14	BAX, AKT1, AURKA, CCND1, DLC1, PIK3CA, FGFR3, AXIN2, TLR4, CTNNB1, DCC, EP300, BRAF, FLCN
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	14	BAX, CTNNB1, CCND1, DLC1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, EP300, PLA2G2A, FLCN
nitrogen compound metabolic process (GO:0006807)	1.13	14	MT-CO1, CTNNB1, CCND1, BAX, TRIM28, ODC1, RAD54B, AXIN2, TP53, AKT1, KAT5, EP300, PLA2G2A, MLH3
positive regulation of molecular function (GO:0044093)	2.23	14	BAX, TLR2, AKT1, DLC1, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TLR4, CTNNB1, EP300, BRAF, FLCN
regulation of biological quality (GO:0065008)	1.68	14	BAX, AKT1, AURKA, CCND1, DLC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, FLCN
positive regulation of phosphorylation (GO:0042327)	2.9	13	BAX, AKT1, CCND1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, EP300, PLA2G2A, FLCN
cellular component assembly (GO:0022607)	2.14	13	APC, BAX, DLC1, BRAF, AURKA, TRIM28, TP53, AXIN2, FLCN, CTNNB1, KAT5, EP300, MLH3
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	13	APC, BAX, AKT1, CCND1, BUB1B, TP53, PTPRJ, TRIM28, CTNNB1, TLR4, KAT5, EP300, FLCN
regulation of organelle organization (GO:0033043)	2.72	13	APC, BAX, AKT1, DLC1, AURKA, BRAF, BUB1B, TP53, AXIN2, TRIM28, CTNNB1, EP300, FLCN
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	13	BAX, TLR2, CTNNB1, CCND1, TRIM28, TP53, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, FLCN
cellular developmental process (GO:0048869)	1.82	13	APC, BAX, AKT1, CCND1, TRIM28, FGFR3, AXIN2, TP53, CTNNB1, DCC, EP300, BRAF, TLR4
negative regulation of cellular metabolic process (GO:0031324)	2.01	13	APC, BAX, AKT1, CCND1, BUB1B, TP53, PTPRJ, TRIM28, CTNNB1, TLR4, KAT5, EP300, FLCN
response to organic substance (GO:0010033)	2.2	13	APC, BAX, AKT1, CCND1, AURKA, PIK3CA, AXIN2, TLR4, CTNNB1, KAT5, EP300, BRAF, TLR2
positive regulation of protein phosphorylation (GO:0001934)	2.95	13	BAX, CTNNB1, CCND1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, EP300, PLA2G2A, FLCN
cellular response to chemical stimulus (GO:0070887)	2.57	13	APC, BAX, AKT1, CCND1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
negative regulation of metabolic process (GO:0009892)	1.93	13	APC, BAX, AKT1, CCND1, BUB1B, TP53, PTPRJ, TRIM28, CTNNB1, TLR4, KAT5, EP300, FLCN
intracellular signal transduction (GO:0035556)	2.39	13	BAX, NRAS, TP53, AURKA, TRIM28, FGFR3, PIK3CA, AKT1, TLR4, KAT5, EP300, BRAF, FLCN
regulation of cell death (GO:0010941)	2.43	13	APC, BAX, AKT1, AURKA, BRAF, DLC1, TP53, AXIN2, PIK3CA, CTNNB1, DCC, EP300, FLCN
regulation of gene expression (GO:0010468)	1.37	13	TLR2, AKT1, CCND1, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, BRAF, FLCN
response to oxygen-containing compound (GO:1901700)	2.57	12	APC, BAX, AKT1, CCND1, AURKA, PIK3CA, TLR4, CTNNB1, KAT5, EP300, BRAF, TLR2
positive regulation of cellular component organization (GO:0051130)	2.68	12	APC, BAX, CTNNB1, BRAF, AURKA, TP53, AXIN2, TRIM28, AKT1, PTPRJ, EP300, TLR4
positive regulation of signal transduction (GO:0009967)	2.5	12	BAX, CTNNB1, PLA2G2A, TP53, FGFR3, AXIN2, TLR2, AKT1, TLR4, PTPRJ, BRAF, FLCN
cellular nitrogen compound metabolic process (GO:0034641)	1.22	12	MT-CO1, AKT1, CCND1, TRIM28, RAD54B, AXIN2, TP53, CTNNB1, KAT5, EP300, ODC1, MLH3
regulation of transferase activity (GO:0051338)	2.88	12	APC, BAX, AKT1, CCND1, BUB1B, PIK3CA, FGFR3, PTPRJ, TP53, CTNNB1, BRAF, TLR4
positive regulation of signaling (GO:0023056)	2.41	12	BAX, TLR2, AKT1, PLA2G2A, TP53, FGFR3, AXIN2, TLR4, CTNNB1, PTPRJ, BRAF, FLCN
negative regulation of signaling (GO:0023057)	2.65	12	APC, BAX, AKT1, CCND1, DLC1, MCC, AXIN2, TLR4, CTNNB1, PTPRJ, BRAF, FLCN
regulation of cell differentiation (GO:0045595)	2.42	12	APC, CTNNB1, CCND1, AURKA, BRAF, AXIN2, TLR4, AKT1, DCC, EP300, PLA2G2A, FLCN
negative regulation of cell communication (GO:0010648)	2.66	12	APC, BAX, AKT1, CCND1, DLC1, MCC, AXIN2, TLR4, CTNNB1, PTPRJ, BRAF, FLCN
phosphorylation (GO:0016310)	2.63	12	MT-CO1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, PIK3CA, AKT1, TLR4, BRAF, TLR2
positive regulation of cell communication (GO:0010647)	2.41	12	BAX, CTNNB1, BRAF, TP53, FGFR3, AXIN2, TLR2, AKT1, TLR4, PTPRJ, PLA2G2A, FLCN
positive regulation of catalytic activity (GO:0043085)	2.4	12	BAX, AKT1, DLC1, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TLR4, CTNNB1, BRAF, FLCN
regulation of cellular localization (GO:0060341)	3.03	11	BAX, AKT1, BRAF, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, EP300, FLCN
macromolecular complex subunit organization (GO:0043933)	2.14	11	APC, BAX, PLA2G2A, AURKA, TRIM28, AXIN2, TP53, CTNNB1, KAT5, EP300, BRAF
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	11	AKT1, CCND1, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
negative regulation of response to stimulus (GO:0048585)	2.52	11	APC, BAX, AKT1, CCND1, DLC1, MCC, AXIN2, TLR4, CTNNB1, PTPRJ, FLCN
regulation of apoptotic process (GO:0042981)	2.5	11	APC, BAX, AKT1, DLC1, BRAF, AURKA, TP53, PIK3CA, CTNNB1, EP300, FLCN
organic substance biosynthetic process (GO:1901576)	1.34	11	AKT1, CCND1, TRIM28, FGFR3, ODC1, TP53, PIK3CA, CTNNB1, KAT5, EP300, PLA2G2A
negative regulation of signal transduction (GO:0009968)	2.75	11	APC, BAX, AKT1, CCND1, DLC1, MCC, AXIN2, TLR4, CTNNB1, PTPRJ, FLCN
regulation of cell cycle process (GO:0010564)	3.5	11	APC, BAX, AKT1, AURKA, CCND1, BUB1B, TP53, AXIN2, CTNNB1, EP300, FLCN
regulation of programmed cell death (GO:0043067)	2.49	11	APC, BAX, AKT1, DLC1, BRAF, AURKA, TP53, PIK3CA, CTNNB1, EP300, FLCN
regulation of cellular biosynthetic process (GO:0031326)	1.38	11	CTNNB1, CCND1, TRIM28, TP53, AXIN2, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
protein phosphorylation (GO:0006468)	2.89	11	NRAS, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TRIM28, AKT1, TLR4, BRAF, TLR2
regulation of biosynthetic process (GO:0009889)	1.37	11	AKT1, CCND1, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	11	AKT1, CCND1, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
cellular response to DNA damage stimulus (GO:0006974)	3.17	11	APC, BAX, CCND1, AURKA, TP53, RAD54B, TRIM28, AKT1, KAT5, EP300, MLH3
biosynthetic process (GO:0009058)	1.32	11	AKT1, PLA2G2A, TRIM28, FGFR3, ODC1, TP53, PIK3CA, CTNNB1, KAT5, EP300, CCND1
regulation of RNA biosynthetic process (GO:2001141)	1.55	11	CTNNB1, CCND1, TRIM28, TP53, AXIN2, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
establishment of localization (GO:0051234)	1.48	11	MT-CO1, TLR2, AKT1, NRAS, CCND1, BAX, MCC, PIK3CA, CTNNB1, BRAF, TLR4
response to abiotic stimulus (GO:0009628)	2.8	11	MT-CO1, AKT1, CCND1, BAX, TP53, RAD54B, CTNNB1, KAT5, EP300, BRAF, TLR4
regulation of cell cycle (GO:0051726)	2.93	11	APC, BAX, AKT1, AURKA, CCND1, BUB1B, TP53, AXIN2, CTNNB1, EP300, FLCN
regulation of RNA metabolic process (GO:0051252)	1.52	11	AKT1, CCND1, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
immune system process (GO:0002376)	2.29	11	BAX, AKT1, NRAS, BRAF, TRIM28, PTPRJ, PIK3CA, CTNNB1, TLR4, EP300, TLR2
regulation of transcription, DNA-templated (GO:0006355)	1.56	11	CTNNB1, CCND1, TRIM28, TP53, AXIN2, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	11	AKT1, CCND1, TRIM28, TP53, AXIN2, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
cellular response to stress (GO:0033554)	2.51	11	APC, BAX, CCND1, AURKA, TP53, RAD54B, TRIM28, AKT1, KAT5, EP300, MLH3
organelle organization (GO:0006996)	2.02	10	BAX, DLC1, AURKA, BUB1B, PIK3CA, RAD54B, AXIN2, TP53, AKT1, MLH3
nucleobase-containing compound metabolic process (GO:0006139)	1.35	10	MT-CO1, CCND1, TRIM28, RAD54B, AXIN2, TP53, CTNNB1, KAT5, EP300, MLH3
regulation of immune system process (GO:0002682)	2.5	10	BAX, AKT1, NRAS, PIK3CA, PTPRJ, TLR2, CTNNB1, TLR4, EP300, FLCN
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	10	BAX, CTNNB1, TRIM28, TP53, TLR2, AKT1, TLR4, KAT5, EP300, FLCN
cellular biosynthetic process (GO:0044249)	1.37	10	AKT1, CCND1, TRIM28, PIK3CA, FGFR3, TP53, CTNNB1, KAT5, EP300, ODC1
regulation of transport (GO:0051049)	2.24	10	BAX, CTNNB1, BRAF, TRIM28, TP53, AXIN2, TLR4, AKT1, EP300, TLR2
regulation of response to stress (GO:0080134)	2.53	10	BAX, NRAS, PLA2G2A, TRIM28, AXIN2, TLR4, AKT1, EP300, BRAF, TLR2
positive regulation of gene expression (GO:0010628)	2.35	10	CTNNB1, BRAF, TRIM28, TP53, TLR2, AKT1, TLR4, KAT5, EP300, FLCN
cellular aromatic compound metabolic process (GO:0006725)	1.3	10	MT-CO1, CCND1, TP53, RAD54B, AXIN2, TRIM28, CTNNB1, KAT5, EP300, MLH3
programmed cell death (GO:0012501)	3.1	10	BAX, DLC1, BUB1B, TP53, FGFR3, TLR4, AKT1, DCC, EP300, TLR2
cellular response to organic substance (GO:0071310)	2.78	10	APC, BAX, AKT1, CCND1, PIK3CA, AXIN2, CTNNB1, KAT5, EP300, TLR4
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	10	AKT1, CCND1, TRIM28, TP53, FLCN, CTNNB1, TLR4, KAT5, EP300, TLR2
regulation of multicellular organismal development (GO:2000026)	2.31	10	BAX, AKT1, CCND1, AXIN2, TLR4, CTNNB1, DCC, EP300, BRAF, FLCN
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	10	BAX, AKT1, TP53, TRIM28, FLCN, CTNNB1, TLR4, KAT5, EP300, TLR2
positive regulation of intracellular signal transduction (GO:1902533)	2.95	10	BAX, BRAF, TP53, FGFR3, PTPRJ, TLR2, CTNNB1, TLR4, PLA2G2A, FLCN
cell death (GO:0008219)	3.05	10	BAX, DLC1, BUB1B, TP53, FGFR3, TLR4, AKT1, DCC, EP300, TLR2
animal organ development (GO:0048513)	2.53	10	APC, BAX, CTNNB1, CCND1, PIK3CA, AKT1, ODC1, EP300, BRAF, FLCN
positive regulation of multicellular organismal process (GO:0051240)	2.49	10	BAX, CTNNB1, CCND1, AURKA, AXIN2, TLR4, AKT1, EP300, BRAF, TLR2
organic cyclic compound metabolic process (GO:1901360)	1.26	10	MT-CO1, CCND1, TP53, RAD54B, AXIN2, TRIM28, CTNNB1, KAT5, EP300, MLH3
heterocycle metabolic process (GO:0046483)	1.31	10	MT-CO1, CCND1, TRIM28, RAD54B, AXIN2, TP53, CTNNB1, KAT5, EP300, MLH3
protein localization (GO:0008104)	2.36	9	AKT1, AURKA, BUB1B, TP53, AXIN2, TLR2, CTNNB1, TLR4, MLH3
positive regulation of biosynthetic process (GO:0009891)	2.29	9	CTNNB1, TP53, TRIM28, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
cell differentiation (GO:0030154)	2.14	9	BAX, CTNNB1, CCND1, TP53, FGFR3, AXIN2, AKT1, EP300, BRAF
nucleic acid metabolic process (GO:0090304)	1.46	9	CCND1, TRIM28, RAD54B, AXIN2, TP53, CTNNB1, KAT5, EP300, MLH3
cell cycle process (GO:0022402)	2.75	9	APC, BAX, AURKA, CCND1, BUB1B, TP53, RAD54B, EP300, MLH3
positive regulation of cell death (GO:0010942)	3.32	9	APC, BAX, CTNNB1, TP53, AXIN2, DLC1, AKT1, EP300, FLCN
anatomical structure morphogenesis (GO:0009653)	2.53	9	BAX, BRAF, TRIM28, FGFR3, AXIN2, CTNNB1, DCC, EP300, DLC1
response to organic cyclic compound (GO:0014070)	3.07	9	BAX, CTNNB1, CCND1, AURKA, AXIN2, AKT1, KAT5, EP300, BRAF
regulation of protein localization (GO:0032880)	2.88	9	CTNNB1, TP53, TRIM28, AXIN2, TLR2, AKT1, TLR4, EP300, FLCN
single-organism metabolic process (GO:0044710)	1.63	9	MT-CO1, NRAS, PLA2G2A, BAX, PIK3CA, FGFR3, AKT1, ODC1, BRAF
positive regulation of transferase activity (GO:0051347)	3.31	9	BAX, CTNNB1, CCND1, BUB1B, PIK3CA, FGFR3, AKT1, BRAF, TLR4
protein complex subunit organization (GO:0071822)	2.6	9	APC, BAX, BRAF, TP53, AXIN2, TRIM28, CTNNB1, KAT5, EP300
regulation of growth (GO:0040008)	3.26	9	TP53, FGFR3, PTPRJ, PIK3CA, AKT1, DCC, KAT5, EP300, FLCN
regulation of kinase activity (GO:0043549)	3.07	9	APC, BAX, CCND1, PIK3CA, FGFR3, PTPRJ, AKT1, BRAF, TLR4
macromolecular complex assembly (GO:0065003)	2.55	9	APC, BAX, BRAF, TP53, AXIN2, TRIM28, CTNNB1, KAT5, EP300
transport (GO:0006810)	1.51	9	MT-CO1, AKT1, CCND1, BAX, PIK3CA, TLR4, CTNNB1, BRAF, TLR2
macromolecule localization (GO:0033036)	2.34	9	AKT1, AURKA, BUB1B, TP53, AXIN2, TLR2, CTNNB1, TLR4, MLH3
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	9	CTNNB1, TP53, TRIM28, TLR2, AKT1, TLR4, KAT5, EP300, FLCN
negative regulation of cell proliferation (GO:0008285)	3.26	9	APC, BAX, DLC1, MCC, AXIN2, TP53, CTNNB1, PTPRJ, FLCN
protein complex assembly (GO:0006461)	2.78	9	APC, BAX, BRAF, TP53, AXIN2, TRIM28, CTNNB1, KAT5, EP300
cell proliferation (GO:0008283)	3.23	9	BAX, AKT1, CCND1, BUB1B, TP53, FGFR3, AXIN2, CTNNB1, TLR4
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	9	CTNNB1, TRIM28, TP53, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
apoptotic process (GO:0006915)	3.14	9	BAX, BUB1B, TP53, FGFR3, DLC1, AKT1, DCC, EP300, TLR2
regulation of mitotic cell cycle (GO:0007346)	3.71	9	APC, BAX, CTNNB1, AURKA, CCND1, BUB1B, TP53, AKT1, EP300
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	9	CTNNB1, TP53, TRIM28, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
negative regulation of protein metabolic process (GO:0051248)	2.82	9	APC, BAX, CTNNB1, BUB1B, PTPRJ, TLR4, AKT1, EP300, FLCN
single-organism localization (GO:1902578)	2.09	9	MT-CO1, CTNNB1, CCND1, BAX, PIK3CA, TLR2, AKT1, BRAF, TLR4
regulation of cellular protein localization (GO:1903827)	3.43	9	TLR2, CTNNB1, TP53, AXIN2, TRIM28, AKT1, TLR4, EP300, FLCN
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	9	APC, BAX, CTNNB1, BUB1B, PTPRJ, TLR4, AKT1, EP300, FLCN
positive regulation of RNA metabolic process (GO:0051254)	2.51	9	CTNNB1, TP53, TRIM28, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	9	CTNNB1, TP53, TRIM28, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
regulation of cellular component biogenesis (GO:0044087)	3.08	9	APC, BAX, BRAF, TP53, PTPRJ, DLC1, CTNNB1, EP300, TLR4
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	9	CTNNB1, TP53, TRIM28, TLR2, AKT1, TLR4, KAT5, EP300, FLCN
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	9	CTNNB1, TP53, TRIM28, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
regulation of chromosome organization (GO:0033044)	4.11	8	APC, BUB1B, TRIM28, AXIN2, TP53, CTNNB1, EP300, FLCN
response to radiation (GO:0009314)	3.69	8	BAX, CCND1, TP53, RAD54B, AKT1, KAT5, EP300, BRAF
negative regulation of gene expression (GO:0010629)	2.48	8	CTNNB1, CCND1, TRIM28, TP53, AKT1, KAT5, EP300, FLCN
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	8	APC, BAX, BUB1B, CCND1, AURKA, TP53, AKT1, EP300
regulation of MAPK cascade (GO:0043408)	3.22	8	CTNNB1, PLA2G2A, FGFR3, PTPRJ, TLR4, AKT1, BRAF, FLCN
organic substance catabolic process (GO:1901575)	2.45	8	APC, CTNNB1, AURKA, PLA2G2A, BUB1B, TP53, AKT1, KAT5
negative regulation of cell cycle (GO:0045786)	3.67	8	APC, BAX, BUB1B, CCND1, AURKA, TP53, CTNNB1, EP300
positive regulation of immune system process (GO:0002684)	2.96	8	BAX, NRAS, PIK3CA, PTPRJ, TLR4, AKT1, EP300, TLR2
negative regulation of apoptotic process (GO:0043066)	3.04	8	BAX, AKT1, BRAF, AURKA, PIK3CA, TP53, CTNNB1, EP300
negative regulation of molecular function (GO:0044092)	2.74	8	APC, BAX, BUB1B, AURKA, TP53, PTPRJ, AKT1, EP300
negative regulation of programmed cell death (GO:0043069)	3.02	8	BAX, AKT1, BRAF, AURKA, PIK3CA, TP53, CTNNB1, EP300
negative regulation of mitotic cell cycle (GO:0045930)	4.45	8	APC, BAX, BUB1B, CCND1, AURKA, TP53, CTNNB1, EP300
negative regulation of cell death (GO:0060548)	2.95	8	BAX, AKT1, BRAF, AURKA, PIK3CA, TP53, CTNNB1, EP300
regulation of protein kinase activity (GO:0045859)	3.15	8	APC, BAX, CCND1, PIK3CA, PTPRJ, AKT1, BRAF, TLR4
establishment of protein localization (GO:0045184)	2.53	8	BAX, CTNNB1, NRAS, BRAF, MCC, TLR4, AKT1, TLR2
regulation of cell cycle phase transition (GO:1901987)	4.15	8	APC, BAX, BUB1B, CCND1, AURKA, TP53, AKT1, EP300
single-organism transport (GO:0044765)	2.18	8	MT-CO1, CTNNB1, CCND1, PIK3CA, TLR4, AKT1, BRAF, TLR2
catabolic process (GO:0009056)	2.38	8	APC, CTNNB1, AURKA, PLA2G2A, BUB1B, TP53, AKT1, KAT5
multi-organism process (GO:0051704)	2.65	8	BAX, PLA2G2A, TP53, TLR2, KAT5, EP300, ODC1, TLR4
regulation of hydrolase activity (GO:0051336)	2.53	8	BAX, TP53, FGFR3, AXIN2, DLC1, AKT1, EP300, FLCN
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	8	AKT1, CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300, ODC1
response to external stimulus (GO:0009605)	2.55	8	CTNNB1, PLA2G2A, TP53, TLR4, AKT1, ODC1, CCND1, TLR2
reproductive process (GO:0022414)	2.55	8	BAX, AKT1, CCND1, AURKA, TRIM28, RAD54B, CTNNB1, MLH3
negative regulation of protein modification process (GO:0031400)	3.4	8	APC, BAX, CTNNB1, BUB1B, PTPRJ, TLR4, AKT1, FLCN
response to drug (GO:0042493)	3.71	8	APC, BAX, CCND1, TP53, RAD54B, CTNNB1, EP300, BRAF
positive regulation of cellular component biogenesis (GO:0044089)	3.71	8	APC, BAX, BRAF, TP53, PTPRJ, CTNNB1, EP300, TLR4
negative regulation of biosynthetic process (GO:0009890)	2.47	7	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300, FLCN
positive regulation of kinase activity (GO:0033674)	3.54	7	BAX, CCND1, PIK3CA, FGFR3, AKT1, BRAF, TLR4
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
regulation of cell adhesion (GO:0030155)	3.27	7	AKT1, BRAF, PIK3CA, PTPRJ, FLCN, CTNNB1, DLC1
regulation of establishment of protein localization (GO:0070201)	3.02	7	TP53, AXIN2, TRIM28, AKT1, TLR4, EP300, TLR2
mitotic cell cycle process (GO:1903047)	3.12	7	APC, BAX, BUB1B, CCND1, AURKA, TP53, EP300
negative regulation of cell cycle process (GO:0010948)	4.37	7	APC, BAX, BUB1B, CCND1, AURKA, TP53, EP300
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	7	APC, BAX, BUB1B, CCND1, AURKA, TP53, EP300
positive regulation of cell differentiation (GO:0045597)	3.01	7	CTNNB1, PLA2G2A, AURKA, AXIN2, AKT1, EP300, BRAF
cellular macromolecule biosynthetic process (GO:0034645)	1.66	7	AKT1, CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
peptidyl-amino acid modification (GO:0018193)	2.98	7	AURKA, TP53, FGFR3, TRIM28, AKT1, KAT5, EP300
multicellular organism development (GO:0007275)	2.54	7	CTNNB1, TRIM28, AXIN2, TP53, AKT1, DCC, FLCN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
response to endogenous stimulus (GO:0009719)	2.79	7	APC, BAX, CTNNB1, CCND1, AKT1, EP300, BRAF
immune response-activating signal transduction (GO:0002757)	3.8	7	BAX, NRAS, PIK3CA, PTPRJ, TLR4, EP300, TLR2
immune response-regulating signaling pathway (GO:0002764)	3.72	7	BAX, NRAS, PIK3CA, PTPRJ, TLR4, EP300, TLR2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
response to lipid (GO:0033993)	3.11	7	BAX, CCND1, AURKA, CTNNB1, KAT5, EP300, TLR4
negative regulation of multicellular organismal process (GO:0051241)	2.84	7	MCC, AXIN2, TLR4, CTNNB1, DCC, KAT5, FLCN
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	7	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300, FLCN
regulation of cell development (GO:0060284)	3.01	7	CTNNB1, BRAF, AURKA, AXIN2, AKT1, DCC, EP300
positive regulation of apoptotic process (GO:0043065)	3.38	7	APC, BAX, AKT1, TP53, DLC1, CTNNB1, FLCN
negative regulation of cellular component organization (GO:0051129)	3.35	7	APC, CTNNB1, BUB1B, DLC1, AKT1, DCC, FLCN
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	7	BAX, BRAF, AXIN2, CTNNB1, DCC, EP300, DLC1
positive regulation of programmed cell death (GO:0043068)	3.38	7	APC, BAX, AKT1, TP53, DLC1, CTNNB1, FLCN
organ morphogenesis (GO:0009887)	3.55	7	BAX, BRAF, FGFR3, AXIN2, CTNNB1, EP300, DLC1
regulation of cell migration (GO:0030334)	3.23	7	APC, BRAF, MCC, PTPRJ, DLC1, AKT1, FLCN
regulation of DNA metabolic process (GO:0051052)	3.87	7	BAX, CTNNB1, TP53, PIK3CA, AXIN2, TRIM28, AKT1
positive regulation of transport (GO:0051050)	2.9	7	BAX, TP53, TRIM28, AKT1, TLR4, EP300, TLR2
regulation of immune response (GO:0050776)	2.98	7	BAX, NRAS, PIK3CA, PTPRJ, TLR4, EP300, TLR2
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
cell activation (GO:0001775)	3.47	7	BAX, CTNNB1, BRAF, PIK3CA, AKT1, EP300, TLR4
regulation of cellular component movement (GO:0051270)	3.08	7	APC, BRAF, MCC, PTPRJ, DLC1, AKT1, FLCN
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
protein catabolic process (GO:0030163)	3.93	7	APC, CTNNB1, BUB1B, AURKA, TP53, AKT1, KAT5
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
regulation of neuron death (GO:1901214)	4.19	7	BAX, AKT1, BRAF, PIK3CA, TP53, CTNNB1, DCC
macromolecule catabolic process (GO:0009057)	3.0	7	APC, CTNNB1, BUB1B, AURKA, TP53, AKT1, KAT5
negative regulation of cell cycle phase transition (GO:1901988)	4.74	7	APC, BAX, BUB1B, CCND1, AURKA, TP53, EP300
locomotion (GO:0040011)	2.91	7	APC, BAX, NRAS, PIK3CA, PTPRJ, CTNNB1, DCC
regulation of protein localization to nucleus (GO:1900180)	4.34	7	TLR2, TRIM28, AXIN2, FLCN, AKT1, EP300, TLR4
regulation of locomotion (GO:0040012)	3.12	7	APC, BRAF, MCC, PTPRJ, DLC1, AKT1, FLCN
positive regulation of developmental process (GO:0051094)	2.77	7	BAX, CCND1, AURKA, AXIN2, CTNNB1, EP300, BRAF
negative regulation of RNA metabolic process (GO:0051253)	2.66	7	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300, FLCN
regulation of cellular response to stress (GO:0080135)	3.4	7	BAX, BRAF, TRIM28, AXIN2, AKT1, EP300, TLR4
positive regulation of organelle organization (GO:0010638)	3.38	7	BAX, BRAF, AURKA, TRIM28, TP53, CTNNB1, EP300
positive regulation of immune response (GO:0050778)	3.4	7	BAX, NRAS, PIK3CA, PTPRJ, TLR4, EP300, TLR2
macromolecule biosynthetic process (GO:0009059)	1.61	7	AKT1, CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300
cellular response to oxygen-containing compound (GO:1901701)	3.22	7	CTNNB1, PIK3CA, TLR4, AKT1, KAT5, EP300, TLR2
regulation of cell motility (GO:2000145)	3.16	7	APC, BRAF, MCC, PTPRJ, DLC1, AKT1, FLCN
activation of immune response (GO:0002253)	3.67	7	BAX, NRAS, PIK3CA, PTPRJ, TLR4, EP300, TLR2
DNA metabolic process (GO:0006259)	3.09	7	TP53, RAD54B, AXIN2, TRIM28, KAT5, EP300, MLH3
system development (GO:0048731)	2.92	7	BAX, CTNNB1, PIK3CA, FGFR3, AKT1, DCC, EP300
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	7	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, FLCN
regulation of cell morphogenesis (GO:0022604)	3.4	6	BRAF, AXIN2, CTNNB1, DCC, EP300, DLC1
regulation of intracellular protein transport (GO:0033157)	3.8	6	TRIM28, AXIN2, TP53, TLR4, EP300, TLR2
regulation of catabolic process (GO:0009894)	3.52	6	APC, BAX, BUB1B, AURKA, AKT1, ODC1
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	6	APC, BAX, PTPRJ, TLR4, AKT1, FLCN
RNA biosynthetic process (GO:0032774)	1.84	6	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
cellular macromolecule catabolic process (GO:0044265)	3.19	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
regulation of intracellular transport (GO:0032386)	3.58	6	TP53, AXIN2, TRIM28, TLR4, EP300, TLR2
apoptotic signaling pathway (GO:0097190)	4.12	6	BAX, TP53, FGFR3, DCC, EP300, TLR4
movement of cell or subcellular component (GO:0006928)	2.61	6	APC, BAX, NRAS, PIK3CA, CTNNB1, DCC
homeostatic process (GO:0042592)	2.61	6	BAX, CTNNB1, PIK3CA, AKT1, EP300, TLR4
response to light stimulus (GO:0009416)	4.08	6	BAX, CCND1, TP53, AKT1, EP300, BRAF
cell migration (GO:0016477)	3.12	6	APC, BAX, NRAS, PIK3CA, CTNNB1, DCC
cellular localization (GO:0051641)	2.32	6	CTNNB1, BUB1B, AURKA, TP53, AXIN2, AKT1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	6	NRAS, PDGFRL, PIK3CA, FGFR3, PTPRJ, AKT1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	6	NRAS, PDGFRL, PIK3CA, FGFR3, PTPRJ, AKT1
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
positive regulation of establishment of protein localization (GO:1904951)	3.49	6	TP53, TRIM28, AKT1, TLR4, EP300, TLR2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	6	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
negative regulation of catalytic activity (GO:0043086)	3.0	6	APC, BUB1B, TP53, PTPRJ, AKT1, EP300
nucleic acid-templated transcription (GO:0097659)	1.91	6	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
regulation of protein transport (GO:0051223)	3.12	6	TRIM28, AXIN2, TP53, TLR4, EP300, TLR2
positive regulation of cell cycle (GO:0045787)	3.94	6	BAX, CCND1, AURKA, TP53, AKT1, EP300
positive regulation of hydrolase activity (GO:0051345)	2.91	6	BAX, FGFR3, AXIN2, FLCN, AKT1, DLC1
chromatin organization (GO:0006325)	3.28	6	AURKA, TRIM28, TP53, CTNNB1, KAT5, EP300
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	4.16	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
negative regulation of phosphate metabolic process (GO:0045936)	3.45	6	APC, BAX, PTPRJ, TLR4, AKT1, FLCN
regulation of cytoskeleton organization (GO:0051493)	3.72	6	APC, BRAF, AURKA, CTNNB1, EP300, DLC1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	6	APC, CTNNB1, CCND1, MCC, AXIN2, AKT1
positive regulation of cellular protein localization (GO:1903829)	3.85	6	TRIM28, TP53, AKT1, TLR4, EP300, TLR2
proteolysis (GO:0006508)	2.73	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
cellular response to abiotic stimulus (GO:0071214)	4.15	6	BAX, CTNNB1, TP53, AKT1, EP300, TLR4
heterocycle biosynthetic process (GO:0018130)	1.7	6	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300
positive regulation of cell proliferation (GO:0008284)	3.01	6	CTNNB1, CCND1, FGFR3, AKT1, ODC1, TLR4
RNA metabolic process (GO:0016070)	1.59	6	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300
single organism reproductive process (GO:0044702)	2.73	6	BAX, AKT1, CCND1, AURKA, TRIM28, CTNNB1
DNA repair (GO:0006281)	3.59	6	TRIM28, RAD54B, TP53, KAT5, EP300, MLH3
modification-dependent protein catabolic process (GO:0019941)	3.71	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
tissue development (GO:0009888)	3.27	6	PTPN12, PIK3CA, FGFR3, AXIN2, CTNNB1, EP300
regulation of cell growth (GO:0001558)	3.75	6	TP53, PTPRJ, AKT1, DCC, EP300, FLCN
regulation of proteolysis (GO:0030162)	3.2	6	BAX, BUB1B, AURKA, AKT1, EP300, DLC1
response to metal ion (GO:0010038)	3.91	6	MT-CO1, CCND1, BAX, CTNNB1, EP300, BRAF
aromatic compound biosynthetic process (GO:0019438)	1.7	6	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	6	CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
response to inorganic substance (GO:0010035)	3.56	6	MT-CO1, CCND1, BAX, CTNNB1, EP300, BRAF
cellular catabolic process (GO:0044248)	2.62	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
system process (GO:0003008)	2.3	6	BRAF, PIK3CA, PTPRJ, AKT1, EP300, TLR4
negative regulation of developmental process (GO:0051093)	3.17	6	CCND1, FGFR3, TLR4, CTNNB1, DCC, FLCN
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
negative regulation of phosphorylation (GO:0042326)	3.7	6	APC, BAX, PTPRJ, TLR4, AKT1, FLCN
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	6	BAX, CCND1, AURKA, TP53, AKT1, EP300
cell motility (GO:0048870)	3.02	6	APC, BAX, NRAS, PIK3CA, CTNNB1, DCC
response to hormone (GO:0009725)	3.33	6	BAX, CTNNB1, CCND1, AKT1, EP300, BRAF
response to organonitrogen compound (GO:0010243)	3.2	6	BAX, CTNNB1, CCND1, AKT1, EP300, BRAF
proteasomal protein catabolic process (GO:0010498)	4.12	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	6	APC, CCND1, PTPRJ, AKT1, BRAF, TLR4
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	6	BAX, CCND1, AURKA, TP53, AKT1, EP300
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	6	APC, BUB1B, AURKA, TP53, CTNNB1, KAT5
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	6	TP53, AXIN2, TRIM28, TLR4, EP300, TLR2
transcription, DNA-templated (GO:0006351)	1.91	6	CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300
positive regulation of proteolysis (GO:0045862)	3.86	6	BAX, BUB1B, AURKA, AKT1, EP300, DLC1
negative regulation of protein phosphorylation (GO:0001933)	3.79	6	APC, BAX, PTPRJ, TLR4, AKT1, FLCN
positive regulation of protein kinase activity (GO:0045860)	3.61	6	BAX, CCND1, PIK3CA, AKT1, BRAF, TLR4
response to nitrogen compound (GO:1901698)	3.12	6	BAX, CTNNB1, CCND1, AKT1, EP300, BRAF
regulation of chromatin organization (GO:1902275)	4.69	5	EP300, TP53, TRIM28, FLCN, CTNNB1
positive regulation of catabolic process (GO:0009896)	3.94	5	APC, BUB1B, BAX, AURKA, AKT1
regulation of Wnt signaling pathway (GO:0030111)	3.98	5	APC, CCND1, AXIN2, TLR2, MCC
positive regulation of intracellular transport (GO:0032388)	4.08	5	TRIM28, EP300, TP53, TLR2, TLR4
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	5	PTPRJ, BAX, EP300, NRAS, PIK3CA
positive regulation of defense response (GO:0031349)	3.83	5	PLA2G2A, EP300, NRAS, TLR2, TLR4
leukocyte activation (GO:0045321)	3.76	5	BAX, EP300, BRAF, CTNNB1, TLR4
regulation of protein catabolic process (GO:0042176)	3.83	5	APC, AURKA, ODC1, BUB1B, AKT1
regulation of neuron apoptotic process (GO:0043523)	4.47	5	TP53, BAX, PIK3CA, CTNNB1, BRAF
regulation of protein targeting (GO:1903533)	4.0	5	AXIN2, EP300, TRIM28, TLR2, TLR4
regulation of protein import into nucleus (GO:0042306)	4.54	5	AXIN2, EP300, TRIM28, TLR2, TLR4
negative regulation of growth (GO:0045926)	4.24	5	DCC, FGFR3, PTPRJ, TP53, FLCN
positive regulation of protein transport (GO:0051222)	3.61	5	TRIM28, EP300, TP53, TLR2, TLR4
signal transduction by p53 class mediator (GO:0072331)	4.88	5	AURKA, BAX, EP300, KAT5, TP53
regulation of cell projection organization (GO:0031344)	3.38	5	DCC, APC, BRAF, EP300, AKT1
cell cycle (GO:0007049)	3.14	5	BUB1B, AURKA, CCND1, EP300, TP53
positive regulation of cell cycle process (GO:0090068)	4.25	5	AURKA, CCND1, EP300, BAX, TP53
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	5	AURKA, CCND1, EP300, BAX, TP53
positive regulation of cell adhesion (GO:0045785)	3.79	5	AKT1, BRAF, PTPRJ, PIK3CA, FLCN
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	5	PTPRJ, BAX, EP300, NRAS, PIK3CA
negative regulation of transferase activity (GO:0051348)	3.87	5	APC, PTPRJ, BUB1B, AKT1, TP53
protein modification by small protein conjugation or removal (GO:0070647)	2.95	5	BUB1B, TP53, AURKA, AKT1, TRIM28
positive regulation of nucleocytoplasmic transport (GO:0046824)	4.93	5	TRIM28, EP300, TP53, TLR2, TLR4
regulation of cytokine production (GO:0001817)	3.4	5	KAT5, EP300, CTNNB1, TLR2, TLR4
interspecies interaction between organisms (GO:0044419)	3.08	5	ODC1, KAT5, EP300, BAX, TP53
protein modification by small protein conjugation (GO:0032446)	3.1	5	BUB1B, TP53, AURKA, TRIM28, AKT1
lymphocyte activation (GO:0046649)	3.96	5	BAX, EP300, BRAF, CTNNB1, TLR4
regulation of nervous system development (GO:0051960)	3.1	5	DCC, BRAF, EP300, AKT1, CTNNB1
regulation of defense response (GO:0031347)	3.11	5	PLA2G2A, EP300, NRAS, TLR2, TLR4
positive regulation of cell development (GO:0010720)	3.57	5	EP300, BRAF, AURKA, AXIN2, CTNNB1
organic substance transport (GO:0071702)	2.15	5	BRAF, CTNNB1, AKT1, TLR2, TLR4
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	5	AURKA, KAT5, EP300, TP53, AKT1
regulation of cell cycle arrest (GO:0071156)	5.05	5	AURKA, CCND1, EP300, BAX, TP53
negative regulation of cell migration (GO:0030336)	4.41	5	DLC1, BRAF, PTPRJ, MCC, FLCN
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	5	AURKA, BAX, EP300, KAT5, TP53
regulation of neurogenesis (GO:0050767)	3.21	5	DCC, BRAF, EP300, AKT1, CTNNB1
cellular macromolecule localization (GO:0070727)	3.1	5	BUB1B, AURKA, AXIN2, TP53, CTNNB1
cellular protein localization (GO:0034613)	3.11	5	BUB1B, AURKA, AXIN2, TP53, CTNNB1
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	5	DCC, AXIN2, BRAF, EP300, CTNNB1
negative regulation of locomotion (GO:0040013)	4.22	5	BRAF, FLCN, PTPRJ, DLC1, MCC
multi-organism cellular process (GO:0044764)	3.14	5	ODC1, EP300, BAX, TP53, KAT5
positive regulation of intracellular protein transport (GO:0090316)	4.19	5	TRIM28, EP300, TP53, TLR2, TLR4
positive regulation of MAPK cascade (GO:0043410)	3.57	5	FGFR3, PLA2G2A, TLR4, CTNNB1, BRAF
negative regulation of cell differentiation (GO:0045596)	3.33	5	DCC, CCND1, AXIN2, TLR4, CTNNB1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	5	TLR4, EP300, AKT1, CTNNB1, TLR2
pattern specification process (GO:0007389)	3.79	5	APC, AXIN2, EP300, AURKA, CTNNB1
response to ionizing radiation (GO:0010212)	4.74	5	RAD54B, CCND1, KAT5, BAX, TP53
negative regulation of intracellular signal transduction (GO:1902532)	3.63	5	FLCN, PTPRJ, DLC1, AKT1, TLR4
regulation of epithelial cell proliferation (GO:0050678)	4.06	5	CCND1, MCC, AKT1, CTNNB1, BAX
negative regulation of neuron death (GO:1901215)	4.57	5	AKT1, BRAF, BAX, PIK3CA, CTNNB1
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	5	CTNNB1, EP300, AKT1, TLR2, TLR4
signal transduction in response to DNA damage (GO:0042770)	5.15	5	AURKA, KAT5, EP300, BAX, TP53
protein oligomerization (GO:0051259)	3.71	5	TP53, BAX, TRIM28, CTNNB1, BRAF
defense response (GO:0006952)	2.78	5	PLA2G2A, AKT1, TRIM28, TLR2, TLR4
negative regulation of cellular component movement (GO:0051271)	4.22	5	PTPRJ, BRAF, MCC, DLC1, FLCN
positive regulation of protein localization to nucleus (GO:1900182)	4.87	5	TRIM28, EP300, AKT1, TLR2, TLR4
organonitrogen compound metabolic process (GO:1901564)	2.32	5	MT-CO1, PLA2G2A, BAX, ODC1, AKT1
nervous system development (GO:0007399)	3.53	5	DCC, BAX, EP300, AKT1, CTNNB1
developmental process involved in reproduction (GO:0003006)	3.36	5	AKT1, CCND1, BAX, TRIM28, CTNNB1
cellular response to organic cyclic compound (GO:0071407)	3.93	5	AXIN2, KAT5, EP300, AKT1, CTNNB1
Wnt signaling pathway (GO:0016055)	3.88	5	APC, CCND1, AXIN2, MCC, CTNNB1
negative regulation of organelle organization (GO:0010639)	4.07	5	APC, AKT1, BUB1B, DLC1, FLCN
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	5	AURKA, CCND1, EP300, BAX, TP53
single-organism organelle organization (GO:1902589)	2.68	5	TP53, BAX, AURKA, DLC1, PIK3CA
response to UV (GO:0009411)	4.88	5	CCND1, EP300, TP53, AKT1, BAX
response to biotic stimulus (GO:0009607)	3.09	5	ODC1, PLA2G2A, TP53, TLR2, TLR4
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	5	DLC1, AXIN2, EP300, PIK3CA, CTNNB1
viral process (GO:0016032)	3.15	5	ODC1, EP300, BAX, TP53, KAT5
negative regulation of cell motility (GO:2000146)	4.36	5	PTPRJ, BRAF, MCC, DLC1, FLCN
regulation of protein import (GO:1904589)	4.52	5	AXIN2, EP300, TRIM28, TLR2, TLR4
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	5	ODC1, EP300, BAX, TP53, KAT5
gland development (GO:0048732)	4.15	5	CCND1, EP300, CTNNB1, PIK3CA, BRAF
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	5	FGFR3, PLA2G2A, TLR4, FLCN, BRAF
cell development (GO:0048468)	3.28	5	BAX, EP300, AKT1, CTNNB1, TLR4
regulation of secretion (GO:0051046)	3.2	4	BRAF, EP300, TLR4, TLR2
regulation of sister chromatid segregation (GO:0033045)	5.63	4	APC, BUB1B, AXIN2, CTNNB1
small molecule metabolic process (GO:0044281)	2.38	4	MT-CO1, AKT1, ODC1, PIK3CA
regulation of histone modification (GO:0031056)	4.85	4	TP53, EP300, FLCN, CTNNB1
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	5.59	4	AURKA, BAX, EP300, TP53
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	5.59	4	AURKA, BAX, EP300, TP53
intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	5.59	4	AURKA, BAX, EP300, TP53
mitochondrion organization (GO:0007005)	3.69	4	BAX, TP53, AKT1, PIK3CA
single-organism biosynthetic process (GO:0044711)	2.8	4	FGFR3, ODC1, PIK3CA, AKT1
response to external biotic stimulus (GO:0043207)	3.13	4	PLA2G2A, ODC1, TLR2, TLR4
signal transduction involved in DNA damage checkpoint (GO:0072422)	5.55	4	AURKA, BAX, EP300, TP53
regulation of apoptotic signaling pathway (GO:2001233)	3.83	4	TP53, BAX, AKT1, CTNNB1
response to growth factor (GO:0070848)	4.14	4	APC, EP300, AKT1, CTNNB1
regulation of neuron differentiation (GO:0045664)	3.39	4	DCC, BRAF, EP300, AKT1
positive regulation of protein import (GO:1904591)	5.08	4	EP300, TRIM28, TLR2, TLR4
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	4	BAX, EP300, DLC1, AKT1
(GO:1905269)	5.25	4	TRIM28, EP300, TP53, CTNNB1
positive regulation of DNA metabolic process (GO:0051054)	4.49	4	BAX, TRIM28, AKT1, CTNNB1
regulation of neuron projection development (GO:0010975)	3.69	4	DCC, BRAF, EP300, AKT1
aging (GO:0007568)	4.16	4	MT-CO1, BAX, TP53, AKT1
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	5.59	4	AURKA, BAX, EP300, TP53
response to other organism (GO:0051707)	3.48	4	PLA2G2A, ODC1, TLR2, TLR4
peptidyl-lysine modification (GO:0018205)	3.98	4	KAT5, EP300, TRIM28, TP53
chemical homeostasis (GO:0048878)	2.97	4	BAX, EP300, PIK3CA, AKT1
protein ubiquitination (GO:0016567)	3.28	4	BUB1B, AURKA, TRIM28, AKT1
organophosphate metabolic process (GO:0019637)	3.04	4	FGFR3, PLA2G2A, MT-CO1, PIK3CA
negative regulation of Wnt signaling pathway (GO:0030178)	4.44	4	APC, CCND1, AXIN2, MCC
signal transduction involved in DNA integrity checkpoint (GO:0072401)	5.55	4	AURKA, BAX, EP300, TP53
positive regulation of GTPase activity (GO:0043547)	3.28	4	FGFR3, AXIN2, DLC1, FLCN
lipid metabolic process (GO:0006629)	2.68	4	FGFR3, PLA2G2A, BAX, PIK3CA
positive regulation of type I interferon production (GO:0032481)	5.48	4	EP300, CTNNB1, TLR2, TLR4
positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	4.65	4	AXIN2, BRAF, EP300, CTNNB1
positive regulation of protein import into nucleus (GO:0042307)	5.11	4	EP300, TRIM28, TLR2, TLR4
regulation of protein complex assembly (GO:0043254)	3.83	4	BAX, TP53, CTNNB1, TLR4
innate immune response-activating signal transduction (GO:0002758)	4.45	4	EP300, NRAS, TLR2, TLR4
activation of innate immune response (GO:0002218)	4.41	4	EP300, NRAS, TLR2, TLR4
response to alcohol (GO:0097305)	4.58	4	APC, CCND1, EP300, CTNNB1
regulation of developmental growth (GO:0048638)	4.04	4	FGFR3, DCC, EP300, PIK3CA
positive regulation of response to external stimulus (GO:0032103)	4.17	4	PLA2G2A, BRAF, TLR2, TLR4
negative regulation of cell growth (GO:0030308)	4.58	4	DCC, PTPRJ, TP53, FLCN
regulation of response to external stimulus (GO:0032101)	3.06	4	PLA2G2A, BRAF, TLR2, TLR4
regulation of secretion by cell (GO:1903530)	3.28	4	BRAF, EP300, TLR4, TLR2
regulation of GTPase activity (GO:0043087)	3.21	4	FGFR3, AXIN2, DLC1, FLCN
protein autophosphorylation (GO:0046777)	4.46	4	FGFR3, AURKA, TRIM28, AKT1
negative regulation of MAPK cascade (GO:0043409)	4.74	4	AKT1, PTPRJ, TLR4, FLCN
regulation of lymphocyte activation (GO:0051249)	3.73	4	AKT1, PIK3CA, CTNNB1, TLR4
signal transduction involved in cell cycle checkpoint (GO:0072395)	5.54	4	AURKA, BAX, EP300, TP53
regulation of cell activation (GO:0050865)	3.53	4	AKT1, PIK3CA, CTNNB1, TLR4
biological adhesion (GO:0022610)	2.81	4	APC, BRAF, BAX, CTNNB1
cellular response to endogenous stimulus (GO:0071495)	3.33	4	APC, EP300, AKT1, CTNNB1
positive regulation of protein catabolic process (GO:0045732)	4.18	4	APC, BUB1B, AURKA, AKT1
cellular response to external stimulus (GO:0071496)	4.2	4	TP53, AKT1, CTNNB1, TLR4
positive regulation of cellular catabolic process (GO:0031331)	4.15	4	BUB1B, BAX, AURKA, AKT1
positive regulation of protein complex assembly (GO:0031334)	4.44	4	BAX, TP53, CTNNB1, TLR4
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)	5.6	4	AURKA, BAX, EP300, TP53
cell-cell junction organization (GO:0045216)	4.66	4	APC, DLC1, FLCN, CTNNB1
cellular lipid metabolic process (GO:0044255)	2.92	4	FGFR3, PLA2G2A, BAX, PIK3CA
cell junction assembly (GO:0034329)	4.86	4	APC, FLCN, DLC1, CTNNB1
regulation of chromosome segregation (GO:0051983)	5.38	4	APC, BUB1B, AXIN2, CTNNB1
cellular response to growth factor stimulus (GO:0071363)	4.27	4	APC, EP300, AKT1, CTNNB1
regulation of binding (GO:0051098)	4.08	4	AURKA, BAX, EP300, CTNNB1
regulation of type I interferon production (GO:0032479)	5.03	4	EP300, CTNNB1, TLR2, TLR4
regulation of mitochondrion organization (GO:0010821)	4.34	4	BAX, FLCN, TP53, AKT1
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	4	FGFR3, PLA2G2A, BRAF, TLR4
positive regulation of cytokine production (GO:0001819)	3.82	4	EP300, TLR2, CTNNB1, TLR4
regulation of cellular catabolic process (GO:0031329)	3.83	4	BUB1B, BAX, AURKA, AKT1
cell projection organization (GO:0030030)	3.14	4	APC, DCC, AURKA, AKT1
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	4	BRAF, BAX, AKT1, PIK3CA
cell junction organization (GO:0034330)	4.51	4	APC, FLCN, DLC1, CTNNB1
liver development (GO:0001889)	4.98	4	CCND1, EP300, PIK3CA, CTNNB1
response to estradiol (GO:0032355)	4.73	4	CCND1, AURKA, KAT5, CTNNB1
regulation of leukocyte activation (GO:0002694)	3.6	4	PIK3CA, AKT1, CTNNB1, TLR4
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	4	BAX, EP300, DLC1, AKT1
cellular component morphogenesis (GO:0032989)	3.5	4	DCC, BAX, TRIM28, CTNNB1
positive regulation of cell cycle arrest (GO:0071158)	5.29	4	AURKA, BAX, EP300, TP53
beta-catenin-TCF complex assembly (GO:1904837)	6.33	4	AXIN2, KAT5, EP300, CTNNB1
establishment of protein localization to organelle (GO:0072594)	3.92	4	BAX, NRAS, AKT1, CTNNB1
positive regulation of innate immune response (GO:0045089)	4.22	4	EP300, NRAS, TLR2, TLR4
regulation of innate immune response (GO:0045088)	3.86	4	EP300, NRAS, TLR2, TLR4
regulation of peptidase activity (GO:0052547)	3.75	4	BAX, EP300, DLC1, AKT1
regulation of endopeptidase activity (GO:0052548)	3.8	4	BAX, EP300, DLC1, AKT1
cell adhesion (GO:0007155)	2.82	4	APC, BRAF, BAX, CTNNB1
chromosome organization (GO:0051276)	3.79	4	BUB1B, RAD54B, AXIN2, MLH3
cell cycle checkpoint (GO:0000075)	4.79	4	APC, CCND1, BUB1B, TP53
signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	5.59	4	AURKA, BAX, EP300, TP53
positive regulation of chromosome organization (GO:2001252)	4.76	4	TRIM28, EP300, TP53, CTNNB1
response to ketone (GO:1901654)	4.53	4	CCND1, EP300, BAX, AKT1
protein transport (GO:0015031)	2.62	4	TLR2, AKT1, CTNNB1, TLR4
mitotic cell cycle checkpoint (GO:0007093)	5.31	4	APC, CCND1, BUB1B, TP53
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	3	BAX, AKT1, CTNNB1
developmental growth (GO:0048589)	4.05	3	FGFR3, AURKA, PTPN12
anatomical structure homeostasis (GO:0060249)	4.25	3	BAX, TLR4, CTNNB1
cellular chemical homeostasis (GO:0055082)	3.4	3	BAX, EP300, PIK3CA
activation of protein kinase activity (GO:0032147)	4.08	3	BRAF, TLR4, PIK3CA
behavior (GO:0007610)	3.47	3	BRAF, EP300, TP53
regulation of homeostatic process (GO:0032844)	3.65	3	BAX, FLCN, CTNNB1
membrane organization (GO:0061024)	3.04	3	BAX, TP53, AKT1
negative regulation of neuron apoptotic process (GO:0043524)	4.82	3	BRAF, BAX, PIK3CA
positive regulation of neuron apoptotic process (GO:0043525)	5.88	3	BAX, TP53, CTNNB1
positive regulation of histone modification (GO:0031058)	5.32	3	EP300, TP53, CTNNB1
glycerolipid metabolic process (GO:0046486)	3.91	3	FGFR3, PLA2G2A, PIK3CA
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	FGFR3, BRAF, NRAS
positive regulation of cell projection organization (GO:0031346)	3.99	3	APC, BRAF, EP300
positive regulation of inflammatory response (GO:0050729)	4.98	3	PLA2G2A, TLR4, TLR2
posttranscriptional regulation of gene expression (GO:0010608)	3.64	3	AXIN2, EP300, AKT1
response to bacterium (GO:0009617)	4.18	3	PLA2G2A, TLR4, TLR2
MAPK cascade (GO:0000165)	3.91	3	FGFR3, BRAF, NRAS
regulation of inflammatory response (GO:0050727)	4.03	3	PLA2G2A, TLR4, TLR2
response to mechanical stimulus (GO:0009612)	4.41	3	AKT1, CTNNB1, TLR4
rhythmic process (GO:0048511)	4.02	3	BAX, EP300, TP53
regulation of transcription factor import into nucleus (GO:0042990)	5.16	3	TRIM28, TLR2, TLR4
regulation of mitotic nuclear division (GO:0007088)	4.83	3	APC, BUB1B, AURKA
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	3	CTNNB1, TLR2, TLR4
negative regulation of immune system process (GO:0002683)	3.85	3	PTPRJ, TLR4, CTNNB1
cellular homeostasis (GO:0019725)	3.23	3	BAX, EP300, PIK3CA
negative regulation of transport (GO:0051051)	3.6	3	BRAF, AXIN2, AKT1
response to corticosteroid (GO:0031960)	4.56	3	CCND1, EP300, BAX
small GTPase mediated signal transduction (GO:0007264)	3.85	3	TP53, NRAS, TRIM28
response to calcium ion (GO:0051592)	4.98	3	CCND1, EP300, BRAF
phosphatidylinositol metabolic process (GO:0046488)	4.46	3	FGFR3, PLA2G2A, PIK3CA
regionalization (GO:0003002)	4.24	3	AXIN2, EP300, CTNNB1
response to peptide hormone (GO:0043434)	4.06	3	BRAF, AKT1, CTNNB1
regulation of hemopoiesis (GO:1903706)	4.0	3	FLCN, CTNNB1, TLR4
positive regulation of transcription factor import into nucleus (GO:0042993)	5.78	3	TRIM28, TLR2, TLR4
oxidation-reduction process (GO:0055114)	2.91	3	BAX, MT-CO1, AKT1
regulation of axonogenesis (GO:0050770)	4.59	3	DCC, BRAF, EP300
lymphocyte aggregation (GO:0071593)	4.44	3	BRAF, BAX, CTNNB1
lipopolysaccharide-mediated signaling pathway (GO:0031663)	6.26	3	AKT1, TLR2, TLR4
response to nutrient levels (GO:0031667)	3.77	3	CCND1, TP53, AKT1
regulation of nuclear division (GO:0051783)	4.67	3	APC, BUB1B, AURKA
regulation of microtubule cytoskeleton organization (GO:0070507)	4.98	3	APC, AURKA, CTNNB1
regulation of canonical Wnt signaling pathway (GO:0060828)	4.26	3	APC, AXIN2, MCC
covalent chromatin modification (GO:0016569)	3.89	3	AURKA, KAT5, EP300
negative regulation of kinase activity (GO:0033673)	4.22	3	APC, PTPRJ, AKT1
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	3	BUB1B, AURKA, AKT1
cellular response to mechanical stimulus (GO:0071260)	5.33	3	AKT1, CTNNB1, TLR4
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	3	TP53, AKT1, TLR4
neuron migration (GO:0001764)	5.0	3	DCC, BAX, CTNNB1
defense response to bacterium (GO:0042742)	4.31	3	PLA2G2A, TLR4, TLR2
axis specification (GO:0009798)	5.42	3	AURKA, AXIN2, CTNNB1
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	3	CCND1, TLR4, AKT1
single-organism membrane organization (GO:0044802)	3.19	3	BAX, TP53, AKT1
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	5.76	3	BAX, EP300, TP53
regulation of protein secretion (GO:0050708)	3.77	3	EP300, TLR4, TLR2
negative regulation of hydrolase activity (GO:0051346)	3.74	3	EP300, TP53, AKT1
regulation of cell-substrate adhesion (GO:0010810)	4.56	3	BRAF, PTPRJ, DLC1
positive regulation of execution phase of apoptosis (GO:1900119)	7.24	3	BAX, DLC1, TP53
histone modification (GO:0016570)	3.91	3	AURKA, KAT5, EP300
cellular response to biotic stimulus (GO:0071216)	4.76	3	TP53, TLR2, TLR4
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	3	FGFR3, AKT1, PIK3CA
regulation of execution phase of apoptosis (GO:1900117)	6.55	3	BAX, TP53, DLC1
single organism cell adhesion (GO:0098602)	3.63	3	BRAF, BAX, CTNNB1
regulation of release of cytochrome c from mitochondria (GO:0090199)	5.94	3	BAX, TP53, AKT1
response to cytokine (GO:0034097)	3.84	3	EP300, AKT1, CTNNB1
cell-cell adhesion (GO:0098609)	3.34	3	BRAF, BAX, CTNNB1
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	3	TP53, AKT1, TLR4
canonical Wnt signaling pathway (GO:0060070)	5.26	3	APC, CCND1, CTNNB1
regulation of multi-organism process (GO:0043900)	3.6	3	AURKA, EP300, TRIM28
cellular response to radiation (GO:0071478)	4.81	3	BAX, EP300, TP53
regulation of protein binding (GO:0043393)	4.6	3	AURKA, BAX, EP300
regulation of protein acetylation (GO:1901983)	5.59	3	KAT5, EP300, FLCN
inflammatory response (GO:0006954)	3.64	3	AKT1, TLR2, TLR4
regulation of actin cytoskeleton organization (GO:0032956)	4.09	3	BRAF, EP300, DLC1
positive regulation of neuron death (GO:1901216)	5.52	3	BAX, TP53, CTNNB1
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	3	FGFR3, PIK3CA, AKT1
leukocyte differentiation (GO:0002521)	4.13	3	BRAF, EP300, CTNNB1
secretion (GO:0046903)	3.38	3	CCND1, TLR4, TLR2
regulation of cyclin-dependent protein kinase activity (GO:1904029)	5.21	3	APC, CCND1, AKT1
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	3	MT-CO1, BAX, AKT1
protein kinase B signaling (GO:0043491)	6.2	3	EP300, AKT1, PIK3CA
cellular response to nitrogen compound (GO:1901699)	3.79	3	EP300, AKT1, CTNNB1
positive regulation of nervous system development (GO:0051962)	3.64	3	BRAF, EP300, CTNNB1
positive regulation of leukocyte activation (GO:0002696)	4.0	3	AKT1, TLR4, PIK3CA
T cell aggregation (GO:0070489)	4.45	3	BRAF, BAX, CTNNB1
cellular response to light stimulus (GO:0071482)	5.22	3	BAX, EP300, TP53
regulation of fibroblast proliferation (GO:0048145)	5.32	3	BAX, TP53, CTNNB1
immune response (GO:0006955)	2.86	3	TRIM28, TLR2, TLR4
response to mineralocorticoid (GO:0051385)	6.23	3	CCND1, EP300, BAX
kidney development (GO:0001822)	4.79	3	ODC1, BAX, CTNNB1
embryo development (GO:0009790)	4.2	3	TRIM28, FLCN, CTNNB1
regulation of MAP kinase activity (GO:0043405)	3.95	3	BRAF, PTPRJ, TLR4
embryo development ending in birth or egg hatching (GO:0009792)	4.35	3	TRIM28, FLCN, CTNNB1
ERBB signaling pathway (GO:0038127)	5.36	3	NRAS, AKT1, PIK3CA
cellular response to UV (GO:0034644)	5.52	3	BAX, EP300, TP53
regulation of microtubule-based process (GO:0032886)	4.79	3	APC, AURKA, CTNNB1
ERBB2 signaling pathway (GO:0038128)	6.09	3	AKT1, NRAS, PIK3CA
response to hypoxia (GO:0001666)	4.13	3	EP300, TP53, AKT1
in utero embryonic development (GO:0001701)	4.4	3	TRIM28, FLCN, CTNNB1
establishment of localization in cell (GO:0051649)	2.47	3	BAX, AKT1, CTNNB1
nuclear division (GO:0000280)	3.85	3	BUB1B, AURKA, MLH3
positive regulation of neurogenesis (GO:0050769)	3.77	3	BRAF, EP300, CTNNB1
inositol lipid-mediated signaling (GO:0048017)	4.91	3	FGFR3, AKT1, PIK3CA
chordate embryonic development (GO:0043009)	4.38	3	TRIM28, FLCN, CTNNB1
response to transition metal nanoparticle (GO:1990267)	4.7	3	CCND1, BAX, MT-CO1
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	4.74	3	BAX, TP53, AKT1
phospholipid metabolic process (GO:0006644)	3.88	3	FGFR3, PLA2G2A, PIK3CA
reproductive structure development (GO:0048608)	4.08	3	BAX, AKT1, CTNNB1
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	3	BUB1B, AURKA, AKT1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	3	TLR2, CTNNB1, TLR4
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	3	BUB1B, AURKA, AKT1
regulation of actin filament-based process (GO:0032970)	3.97	3	BRAF, EP300, DLC1
cellular response to lipid (GO:0071396)	3.96	3	KAT5, EP300, TLR4
B cell activation (GO:0042113)	4.84	3	BAX, EP300, TLR4
cellular response to hormone stimulus (GO:0032870)	3.99	3	EP300, AKT1, CTNNB1
defense response to other organism (GO:0098542)	3.75	3	PLA2G2A, TLR4, TLR2
T cell activation (GO:0042110)	4.45	3	BRAF, BAX, CTNNB1
tissue homeostasis (GO:0001894)	4.78	3	BAX, TLR4, CTNNB1
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	3	BAX, EP300, TP53
response to oxidative stress (GO:0006979)	3.9	3	MT-CO1, EP300, AKT1
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	3	CCND1, CTNNB1, AKT1
glucose homeostasis (GO:0042593)	4.6	3	EP300, PIK3CA, AKT1
positive regulation of lymphocyte activation (GO:0051251)	4.07	3	AKT1, TLR4, PIK3CA
carbohydrate derivative metabolic process (GO:1901135)	3.07	3	MT-CO1, BAX, AKT1
lymphocyte differentiation (GO:0030098)	4.49	3	BRAF, EP300, CTNNB1
response to decreased oxygen levels (GO:0036293)	4.09	3	EP300, TP53, AKT1
protein localization to organelle (GO:0033365)	3.57	3	BUB1B, AURKA, CTNNB1
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	3	AKT1, PIK3CA, CTNNB1
response to steroid hormone (GO:0048545)	4.24	3	CCND1, EP300, BAX
response to endoplasmic reticulum stress (GO:0034976)	4.46	3	CCND1, BAX, TP53
cellular response to nerve growth factor stimulus (GO:1990090)	6.23	3	APC, EP300, AKT1
response to glucocorticoid (GO:0051384)	4.63	3	CCND1, EP300, BAX
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	3	BRAF, AKT1, PIK3CA
glycerophospholipid metabolic process (GO:0006650)	4.13	3	FGFR3, PLA2G2A, PIK3CA
positive regulation of cell activation (GO:0050867)	3.97	3	TLR4, AKT1, PIK3CA
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	3	BAX, EP300, TP53
extrinsic apoptotic signaling pathway (GO:0097191)	5.16	3	DCC, FGFR3, BAX
regulation of T cell activation (GO:0050863)	4.05	3	AKT1, CTNNB1, PIK3CA
meiotic cell cycle process (GO:1903046)	4.71	3	RAD54B, AURKA, MLH3
cell cycle phase transition (GO:0044770)	4.24	3	BUB1B, CCND1, AURKA
regulation of cell-cell adhesion (GO:0022407)	3.79	3	AKT1, CTNNB1, PIK3CA
mitotic cell cycle phase transition (GO:0044772)	4.27	3	BUB1B, CCND1, AURKA
cellular response to drug (GO:0035690)	5.48	3	BRAF, EP300, TP53
generation of precursor metabolites and energy (GO:0006091)	4.07	3	MT-CO1, BAX, AKT1
cell division (GO:0051301)	3.68	3	BUB1B, CCND1, AURKA
growth (GO:0040007)	3.8	3	FGFR3, AURKA, PTPN12
cellular response to organonitrogen compound (GO:0071417)	3.87	3	EP300, AKT1, CTNNB1
carbohydrate homeostasis (GO:0033500)	4.6	3	EP300, AKT1, PIK3CA
regulation of ion transport (GO:0043269)	3.4	3	BAX, AKT1, CTNNB1
hematopoietic or lymphoid organ development (GO:0048534)	4.49	3	BRAF, FLCN, CTNNB1
regulation of autophagy (GO:0010506)	4.21	3	EP300, AKT1, FLCN
negative regulation of canonical Wnt signaling pathway (GO:0090090)	4.63	3	APC, AXIN2, MCC
antigen receptor-mediated signaling pathway (GO:0050851)	4.43	3	BAX, PTPRJ, PIK3CA
negative regulation of protein kinase activity (GO:0006469)	4.29	3	APC, PTPRJ, AKT1
regulation of cellular protein catabolic process (GO:1903362)	4.23	3	BUB1B, AURKA, AKT1
response to nerve growth factor (GO:1990089)	6.15	3	APC, EP300, AKT1
innate immune response (GO:0045087)	3.55	3	TRIM28, TLR2, TLR4
regulation of metal ion transport (GO:0010959)	3.94	3	BAX, AKT1, CTNNB1
single organismal cell-cell adhesion (GO:0016337)	3.69	3	BRAF, BAX, CTNNB1
cellular component disassembly (GO:0022411)	3.52	3	APC, PIK3CA, CTNNB1
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	3	BAX, AKT1, CTNNB1
response to estrogen (GO:0043627)	5.25	3	CCND1, EP300, CTNNB1
cell communication (GO:0007154)	3.04	3	FGFR3, TP53, CTNNB1
Ras protein signal transduction (GO:0007265)	4.76	3	TP53, TRIM28, NRAS
leukocyte aggregation (GO:0070486)	4.41	3	BRAF, BAX, CTNNB1
leukocyte cell-cell adhesion (GO:0007159)	4.26	3	BRAF, BAX, CTNNB1
response to oxygen levels (GO:0070482)	4.02	3	EP300, TP53, AKT1
germ cell development (GO:0007281)	4.75	3	BAX, AKT1, CTNNB1
odontogenesis (GO:0042476)	5.19	3	BAX, AXIN2, CTNNB1
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	5.26	3	APC, CCND1, AKT1
response to peptide (GO:1901652)	3.94	3	BRAF, AKT1, CTNNB1
organelle fission (GO:0048285)	3.79	3	BUB1B, AURKA, MLH3
response to extracellular stimulus (GO:0009991)	3.71	3	CCND1, TP53, AKT1
skeletal system development (GO:0001501)	4.49	2	FGFR3, CTNNB1
ossification (GO:0001503)	4.86	2	FGFR3, AXIN2
double-strand break repair (GO:0006302)	4.73	2	KAT5, RAD54B
lipid modification (GO:0030258)	4.37	2	FGFR3, PIK3CA
positive regulation of cytoskeleton organization (GO:0051495)	4.58	2	BRAF, EP300
negative regulation of cytoskeleton organization (GO:0051494)	5.01	2	APC, DLC1
regulation of stress fiber assembly (GO:0051492)	5.49	2	BRAF, DLC1
regulation of epithelial cell differentiation (GO:0030856)	4.96	2	CCND1, CTNNB1
negative regulation of epithelial cell differentiation (GO:0030857)	6.09	2	CCND1, CTNNB1
epithelial cell differentiation (GO:0030855)	3.98	2	AKT1, CTNNB1
regulation of DNA repair (GO:0006282)	5.4	2	AXIN2, TRIM28
cellular response to hypoxia (GO:0071456)	5.11	2	TP53, AKT1
protein heterooligomerization (GO:0051291)	5.22	2	BRAF, CTNNB1
nucleotide-excision repair (GO:0006289)	5.05	2	EP300, TP53
defense response to Gram-positive bacterium (GO:0050830)	5.54	2	PLA2G2A, TLR2
somitogenesis (GO:0001756)	5.9	2	AXIN2, EP300
regulation of epithelial cell migration (GO:0010632)	4.62	2	MCC, AKT1
response to monosaccharide (GO:0034284)	4.77	2	EP300, PIK3CA
positive regulation of cell-substrate adhesion (GO:0010811)	5.11	2	BRAF, PTPRJ
negative regulation of nuclear division (GO:0051784)	5.94	2	APC, BUB1B
muscle cell differentiation (GO:0042692)	5.09	2	AKT1, CTNNB1
digestive tract development (GO:0048565)	5.49	2	EP300, CTNNB1
embryonic organ development (GO:0048568)	4.86	2	AKT1, CTNNB1
positive regulation of Wnt signaling pathway (GO:0030177)	4.7	2	AXIN2, TLR2
regulation of adherens junction organization (GO:1903391)	5.8	2	PTPRJ, DLC1
lymphocyte proliferation (GO:0046651)	5.35	2	BAX, TLR4
negative regulation of protein serine/threonine kinase activity (GO:0071901)	4.92	2	APC, PTPRJ
regulation of mitotic metaphase/anaphase transition (GO:0030071)	5.92	2	APC, BUB1B
negative regulation of protein binding (GO:0032091)	5.36	2	BAX, AURKA
cell morphogenesis involved in differentiation (GO:0000904)	4.67	2	TRIM28, CTNNB1
cell morphogenesis (GO:0000902)	4.35	2	TRIM28, CTNNB1
anterior/posterior axis specification (GO:0009948)	6.17	2	AURKA, CTNNB1
hexose transport (GO:0008645)	5.76	2	BRAF, AKT1
intracellular protein transport (GO:0006886)	3.2	2	AKT1, CTNNB1
carbohydrate transport (GO:0008643)	5.16	2	BRAF, AKT1
phosphatidylinositol phosphorylation (GO:0046854)	5.19	2	FGFR3, PIK3CA
regulation of telomerase activity (GO:0051972)	5.97	2	TP53, CTNNB1
circadian rhythm (GO:0007623)	4.79	2	EP300, TP53
protein secretion (GO:0009306)	4.97	2	TLR4, TLR2
regulation of DNA biosynthetic process (GO:2000278)	5.17	2	TP53, CTNNB1
positive regulation of nuclease activity (GO:0032075)	7.02	2	BAX, AKT1
cell cycle arrest (GO:0007050)	4.69	2	APC, TP53
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	PIK3CA, AKT1
regulation of glycoprotein biosynthetic process (GO:0010559)	6.09	2	EP300, CTNNB1
regulation of genetic imprinting (GO:2000653)	8.34	2	TRIM28, PIK3CA
negative regulation of chromosome organization (GO:2001251)	5.17	2	APC, BUB1B
cellular response to metal ion (GO:0071248)	4.81	2	BRAF, CTNNB1
negative regulation of fibroblast proliferation (GO:0048147)	6.4	2	BAX, TP53
regulation of Ras protein signal transduction (GO:0046578)	4.49	2	DLC1, FLCN
cellular response to inorganic substance (GO:0071241)	4.67	2	BRAF, CTNNB1
response to purine-containing compound (GO:0014074)	4.67	2	BRAF, EP300
protein complex disassembly (GO:0043241)	4.58	2	APC, CTNNB1
negative regulation of cellular protein localization (GO:1903828)	4.82	2	AXIN2, FLCN
meiotic nuclear division (GO:0007126)	5.37	2	AURKA, MLH3
regulation of mRNA stability (GO:0043488)	4.81	2	AXIN2, AKT1
regulation of RNA stability (GO:0043487)	4.78	2	AXIN2, AKT1
positive regulation of nitric oxide metabolic process (GO:1904407)	5.99	2	TLR4, AKT1
toll-like receptor signaling pathway (GO:0002224)	5.26	2	TLR4, TLR2
innate immune response activating cell surface receptor signaling pathway (GO:0002220)	5.07	2	EP300, NRAS
pattern recognition receptor signaling pathway (GO:0002221)	5.02	2	TLR4, TLR2
regulation of interleukin-8 production (GO:0032677)	5.62	2	TLR4, TLR2
insulin receptor signaling pathway (GO:0008286)	5.33	2	PIK3CA, AKT1
regulation of body fluid levels (GO:0050878)	3.76	2	CCND1, TLR4
neurological system process (GO:0050877)	2.64	2	BRAF, EP300
positive regulation of T cell activation (GO:0050870)	4.39	2	AKT1, PIK3CA
negative regulation of chromosome segregation (GO:0051985)	6.47	2	APC, BUB1B
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	7.09	2	KAT5, TP53
dorsal/ventral axis specification (GO:0009950)	7.02	2	AXIN2, CTNNB1
glycerophospholipid biosynthetic process (GO:0046474)	4.62	2	FGFR3, PIK3CA
peptidyl-serine phosphorylation (GO:0018105)	4.82	2	AURKA, AKT1
positive regulation of growth (GO:0045927)	4.25	2	EP300, AKT1
extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)	6.23	2	DCC, BAX
leukocyte migration (GO:0050900)	4.19	2	NRAS, PIK3CA
cell cycle phase (GO:0022403)	4.39	2	CCND1, BUB1B
negative regulation of mitochondrion organization (GO:0010823)	6.07	2	FLCN, AKT1
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	BAX, TP53
fat cell differentiation (GO:0045444)	5.02	2	CCND1, EP300
segmentation (GO:0035282)	5.8	2	AXIN2, EP300
regulation of cell division (GO:0051302)	4.88	2	AURKA, FLCN
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	AKT1, PIK3CA
negative regulation of cysteine-type endopeptidase activity (GO:2000117)	5.25	2	EP300, AKT1
leukocyte proliferation (GO:0070661)	5.25	2	BAX, TLR4
regulation of leukocyte proliferation (GO:0070663)	4.4	2	TLR4, CTNNB1
response to copper ion (GO:0046688)	6.29	2	MT-CO1, BAX
positive regulation of gene expression, epigenetic (GO:0045815)	5.76	2	EP300, CTNNB1
response to organophosphorus (GO:0046683)	4.79	2	BRAF, EP300
embryonic morphogenesis (GO:0048598)	3.72	2	TRIM28, CTNNB1
regulation of lipid metabolic process (GO:0019216)	4.08	2	FGFR3, AKT1
regulation of protein deacetylation (GO:0090311)	6.23	2	EP300, TP53
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	EP300, AKT1
positive regulation of endopeptidase activity (GO:0010950)	4.78	2	BAX, DLC1
positive regulation of peptidase activity (GO:0010952)	4.7	2	BAX, DLC1
positive regulation of cellular component movement (GO:0051272)	3.71	2	APC, AKT1
positive regulation of locomotion (GO:0040017)	3.71	2	APC, AKT1
regulation of cell size (GO:0008361)	5.42	2	EP300, AKT1
epithelial to mesenchymal transition (GO:0001837)	5.76	2	TRIM28, CTNNB1
negative regulation of leukocyte differentiation (GO:1902106)	5.3	2	TLR4, CTNNB1
regulation of leukocyte differentiation (GO:1902105)	4.26	2	TLR4, CTNNB1
regulation of organ morphogenesis (GO:2000027)	4.22	2	BAX, CTNNB1
regulation of peptidyl-lysine acetylation (GO:2000756)	5.67	2	EP300, FLCN
negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	6.64	2	APC, BUB1B
regulation of translation (GO:0006417)	3.96	2	EP300, AKT1
regulation of protein oligomerization (GO:0032459)	6.17	2	BAX, TP53
positive regulation of interleukin-8 production (GO:0032757)	5.92	2	TLR4, TLR2
positive regulation of interleukin-6 production (GO:0032755)	5.51	2	TLR4, TLR2
detection of biotic stimulus (GO:0009595)	6.55	2	TLR4, TLR2
detection of chemical stimulus (GO:0009593)	3.49	2	TLR4, TLR2
positive regulation of reproductive process (GO:2000243)	5.8	2	AURKA, CTNNB1
positive regulation of lymphocyte apoptotic process (GO:0070230)	6.64	2	BAX, TP53
regulation of reproductive process (GO:2000241)	4.88	2	AURKA, CTNNB1
learning or memory (GO:0007611)	4.33	2	BRAF, EP300
circulatory system process (GO:0003013)	4.38	2	PTPRJ, AKT1
response to corticosterone (GO:0051412)	6.55	2	CCND1, BAX
vascular process in circulatory system (GO:0003018)	4.65	2	PTPRJ, AKT1
mitochondrial membrane organization (GO:0007006)	5.2	2	BAX, TP53
neuron projection guidance (GO:0097485)	4.43	2	DCC, NRAS
regulation of osteoblast differentiation (GO:0045667)	4.99	2	AXIN2, CTNNB1
positive regulation of neuron differentiation (GO:0045666)	3.98	2	BRAF, EP300
cellular response to hexose stimulus (GO:0071331)	5.65	2	EP300, PIK3CA
cellular response to glucose stimulus (GO:0071333)	5.69	2	EP300, PIK3CA
chondrocyte differentiation (GO:0002062)	5.88	2	FGFR3, AXIN2
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	FGFR3, PIK3CA
T cell costimulation (GO:0031295)	5.35	2	AKT1, PIK3CA
lymphocyte costimulation (GO:0031294)	5.33	2	AKT1, PIK3CA
regulation of small GTPase mediated signal transduction (GO:0051056)	4.08	2	DLC1, FLCN
detection of external biotic stimulus (GO:0098581)	6.68	2	TLR4, TLR2
negative regulation of DNA metabolic process (GO:0051053)	4.98	2	TRIM28, TP53
T cell differentiation (GO:0030217)	5.11	2	BRAF, CTNNB1
negative regulation of small GTPase mediated signal transduction (GO:0051058)	6.04	2	DLC1, FLCN
regulation of response to DNA damage stimulus (GO:2001020)	4.74	2	AXIN2, TRIM28
negative regulation of hemopoiesis (GO:1903707)	4.96	2	TLR4, CTNNB1
stem cell population maintenance (GO:0019827)	4.83	2	BRAF, CTNNB1
peptidyl-serine modification (GO:0018209)	4.72	2	AURKA, AKT1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	2	FGFR3, TP53
G1 DNA damage checkpoint (GO:0044783)	7.24	2	CCND1, TP53
chromatin modification (GO:0016568)	4.06	2	KAT5, TRIM28
negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	6.68	2	APC, BUB1B
positive regulation of cell migration (GO:0030335)	3.77	2	APC, AKT1
platelet-derived growth factor receptor signaling pathway (GO:0048008)	6.15	2	PDGFRL, PTPRJ
regulation of JNK cascade (GO:0046328)	4.65	2	TLR4, AKT1
bone mineralization (GO:0030282)	6.09	2	FGFR3, AXIN2
regulation of myeloid leukocyte differentiation (GO:0002761)	5.02	2	TLR4, CTNNB1
negative regulation of myeloid leukocyte differentiation (GO:0002762)	5.9	2	TLR4, CTNNB1
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	5.26	2	BAX, DLC1
transcription from RNA polymerase II promoter (GO:0006366)	3.38	2	EP300, TP53
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	PDGFRL, AKT1
positive regulation of tumor necrosis factor production (GO:0032760)	5.7	2	TLR4, TLR2
regulation of viral process (GO:0050792)	3.89	2	EP300, TRIM28
hexose metabolic process (GO:0019318)	4.64	2	PIK3CA, AKT1
organophosphate biosynthetic process (GO:0090407)	3.67	2	FGFR3, PIK3CA
anterior/posterior pattern specification (GO:0009952)	4.71	2	AXIN2, EP300
positive regulation of epithelial to mesenchymal transition (GO:0010718)	6.23	2	AXIN2, CTNNB1
regulation of epithelial to mesenchymal transition (GO:0010717)	5.55	2	AXIN2, CTNNB1
cognition (GO:0050890)	4.2	2	BRAF, EP300
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154)	5.29	2	EP300, AKT1
negative regulation of nervous system development (GO:0051961)	4.15	2	DCC, CTNNB1
positive regulation of cell motility (GO:2000147)	3.74	2	APC, AKT1
regulation of nuclease activity (GO:0032069)	6.59	2	BAX, AKT1
negative regulation of sister chromatid segregation (GO:0033046)	6.51	2	APC, BUB1B
regulation of mitotic sister chromatid segregation (GO:0033047)	5.78	2	APC, BUB1B
vasculature development (GO:0001944)	6.04	2	PIK3CA, CTNNB1
negative regulation of mitotic sister chromatid segregation (GO:0033048)	6.59	2	APC, BUB1B
regulation of mammary gland epithelial cell proliferation (GO:0033599)	6.84	2	CCND1, BAX
cell-cell junction assembly (GO:0007043)	5.42	2	APC, FLCN
steroid hormone mediated signaling pathway (GO:0043401)	4.9	2	KAT5, CTNNB1
peptidyl-tyrosine dephosphorylation (GO:0035335)	5.1	2	PTPRJ, PTPN12
regulation of cellular response to growth factor stimulus (GO:0090287)	4.29	2	FLCN, CTNNB1
cellular response to peptide hormone stimulus (GO:0071375)	4.63	2	AKT1, CTNNB1
regulation of system process (GO:0044057)	3.53	2	EP300, AKT1
positive regulation of glycoprotein biosynthetic process (GO:0010560)	6.84	2	EP300, CTNNB1
regeneration (GO:0031099)	4.7	2	CCND1, PTPN12
regulation of cellular ketone metabolic process (GO:0010565)	4.67	2	ODC1, AKT1
negative regulation of neurogenesis (GO:0050768)	4.22	2	DCC, CTNNB1
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	PIK3CA, AKT1
regulation of fibroblast migration (GO:0010762)	6.4	2	BRAF, AKT1
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	5.76	2	BAX, TP53
regulation of response to wounding (GO:1903034)	4.74	2	BRAF, TLR4
positive regulation of response to wounding (GO:1903036)	5.76	2	BRAF, TLR4
multicellular organismal reproductive process (GO:0048609)	3.35	2	BAX, AKT1
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	4.44	2	TLR4, AKT1
regulation of toll-like receptor signaling pathway (GO:0034121)	5.88	2	TLR4, TLR2
positive regulation of ion transport (GO:0043270)	4.36	2	BAX, AKT1
reciprocal meiotic recombination (GO:0007131)	6.33	2	RAD54B, MLH3
response to molecule of bacterial origin (GO:0002237)	3.99	2	TLR4, TLR2
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901030)	6.12	2	BAX, TP53
regulation of membrane permeability (GO:0090559)	5.48	2	BAX, TP53
negative regulation of ERK1 and ERK2 cascade (GO:0070373)	5.74	2	TLR4, FLCN
lung development (GO:0030324)	5.13	2	EP300, CTNNB1
adherens junction assembly (GO:0034333)	6.2	2	DLC1, CTNNB1
adherens junction organization (GO:0034332)	5.48	2	DLC1, CTNNB1
regulation of muscle cell differentiation (GO:0051147)	4.68	2	EP300, CTNNB1
positive regulation of muscle cell differentiation (GO:0051149)	5.26	2	EP300, CTNNB1
protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	4.83	2	BUB1B, AURKA
positive regulation of mitotic cell cycle (GO:0045931)	4.98	2	CCND1, AURKA
spindle checkpoint (GO:0031577)	6.47	2	APC, BUB1B
regulation of proteasomal protein catabolic process (GO:0061136)	4.78	2	AURKA, AKT1
response to ethanol (GO:0045471)	4.83	2	CCND1, EP300
regulation of cartilage development (GO:0061035)	5.6	2	AXIN2, CTNNB1
cell-cell signaling (GO:0007267)	3.35	2	FGFR3, CTNNB1
determination of adult lifespan (GO:0008340)	7.09	2	RAD54B, TP53
tube development (GO:0035295)	4.41	2	EP300, CTNNB1
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	EP300, AKT1
lipid biosynthetic process (GO:0008610)	3.49	2	FGFR3, PIK3CA
response to hexose (GO:0009746)	4.82	2	EP300, PIK3CA
heart development (GO:0007507)	4.24	2	EP300, CTNNB1
carbohydrate metabolic process (GO:0005975)	3.26	2	PIK3CA, AKT1
positive regulation of NF-kappaB import into nucleus (GO:0042346)	6.43	2	TLR4, TLR2
regulation of NF-kappaB import into nucleus (GO:0042345)	5.86	2	TLR4, TLR2
regulation of leukocyte apoptotic process (GO:2000106)	5.33	2	BAX, TP53
response to glucose (GO:0009749)	4.86	2	EP300, PIK3CA
positive regulation of apoptotic signaling pathway (GO:2001235)	4.58	2	BAX, TP53
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	BAX, AKT1
positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)	5.47	2	AURKA, AKT1
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	5.05	2	AURKA, AKT1
protein dephosphorylation (GO:0006470)	4.47	2	PTPRJ, PTPN12
protein acetylation (GO:0006473)	4.86	2	KAT5, EP300
internal protein amino acid acetylation (GO:0006475)	4.99	2	KAT5, EP300
positive regulation of homeostatic process (GO:0032846)	4.38	2	BAX, CTNNB1
regulation of mitotic sister chromatid separation (GO:0010965)	5.9	2	APC, BUB1B
regulation of cell-substrate junction assembly (GO:0090109)	5.84	2	PTPRJ, DLC1
regulation of gene expression, epigenetic (GO:0040029)	4.58	2	EP300, CTNNB1
regulation of chondrocyte differentiation (GO:0032330)	5.92	2	AXIN2, CTNNB1
positive regulation of interferon-beta production (GO:0032728)	6.29	2	TLR4, TLR2
negative regulation of cell development (GO:0010721)	4.02	2	DCC, CTNNB1
positive regulation of chemokine production (GO:0032722)	5.82	2	TLR4, TLR2
regulation of lymphocyte apoptotic process (GO:0070228)	5.7	2	BAX, TP53
regulation of interleukin-12 production (GO:0032655)	5.78	2	TLR4, TLR2
histone acetylation (GO:0016573)	5.09	2	KAT5, EP300
regulation of cell junction assembly (GO:1901888)	5.49	2	PTPRJ, DLC1
lymphocyte apoptotic process (GO:0070227)	6.84	2	BAX, AKT1
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	2	NRAS, PIK3CA
establishment of protein localization to mitochondrion (GO:0072655)	5.63	2	BAX, AKT1
regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	5.9	2	APC, BUB1B
single organism signaling (GO:0044700)	3.25	2	FGFR3, CTNNB1
vesicle-mediated transport (GO:0016192)	2.72	2	PIK3CA, CTNNB1
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	ODC1, AKT1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	2	FGFR3, TP53
cellular response to carbohydrate stimulus (GO:0071322)	5.52	2	EP300, PIK3CA
cellular response to monosaccharide stimulus (GO:0071326)	5.65	2	EP300, PIK3CA
regulation of cellular component size (GO:0032535)	4.21	2	EP300, AKT1
regulation of DNA binding (GO:0051101)	5.21	2	EP300, CTNNB1
negative regulation of binding (GO:0051100)	4.85	2	BAX, AURKA
negative regulation of mitotic sister chromatid separation (GO:2000816)	6.68	2	APC, BUB1B
developmental maturation (GO:0021700)	4.7	2	FGFR3, CTNNB1
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	7.09	2	TLR4, TLR2
protein acylation (GO:0043543)	4.65	2	KAT5, EP300
DNA integrity checkpoint (GO:0031570)	5.25	2	CCND1, TP53
mitotic G1 DNA damage checkpoint (GO:0031571)	7.33	2	CCND1, TP53
regulation of anatomical structure size (GO:0090066)	3.78	2	EP300, AKT1
positive regulation of cyclin-dependent protein kinase activity (GO:1904031)	6.15	2	CCND1, AKT1
cellular response to molecule of bacterial origin (GO:0071219)	4.88	2	TLR4, TLR2
negative regulation of developmental growth (GO:0048640)	5.25	2	DCC, FGFR3
internal peptidyl-lysine acetylation (GO:0018393)	5.05	2	KAT5, EP300
beta-catenin destruction complex disassembly (GO:1904886)	6.64	2	APC, CTNNB1
peptidyl-lysine acetylation (GO:0018394)	5.03	2	KAT5, EP300
ion transport (GO:0006811)	2.66	2	MT-CO1, BAX
positive regulation of multi-organism process (GO:0043902)	4.68	2	AURKA, EP300
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	2	EP300, TRIM28
cellular respiration (GO:0045333)	5.9	2	MT-CO1, BAX
cellular glucose homeostasis (GO:0001678)	5.48	2	EP300, PIK3CA
regulation of ossification (GO:0030278)	4.53	2	AXIN2, CTNNB1
negative regulation of protein localization to nucleus (GO:1900181)	5.49	2	AXIN2, FLCN
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	6.2	2	TLR4, TLR2
regulation of mitochondrial membrane permeability (GO:0046902)	5.55	2	BAX, TP53
detection of stimulus (GO:0051606)	3.22	2	TLR4, TLR2
intracellular transport (GO:0046907)	2.67	2	AKT1, CTNNB1
cellular response to decreased oxygen levels (GO:0036294)	5.05	2	TP53, AKT1
leukocyte apoptotic process (GO:0071887)	6.59	2	BAX, AKT1
pancreas development (GO:0031016)	6.47	2	APC, CTNNB1
positive regulation of release of cytochrome c from mitochondria (GO:0090200)	6.4	2	BAX, TP53
negative regulation of Rho protein signal transduction (GO:0035024)	7.09	2	DLC1, FLCN
positive regulation of nitric oxide biosynthetic process (GO:0045429)	5.99	2	TLR4, AKT1
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	2	TLR4, AKT1
response to antibiotic (GO:0046677)	5.86	2	EP300, TP53
regulation of Rho protein signal transduction (GO:0035023)	5.02	2	DLC1, FLCN
I-kappaB phosphorylation (GO:0007252)	7.24	2	TLR4, TLR2
cell fate specification (GO:0001708)	5.57	2	APC, CTNNB1
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)	5.6	2	EP300, TP53
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	2	BUB1B, CTNNB1
lipid phosphorylation (GO:0046834)	5.13	2	FGFR3, PIK3CA
signal transduction in absence of ligand (GO:0038034)	6.23	2	DCC, BAX
response to UV-A (GO:0070141)	7.94	2	CCND1, AKT1
regulation of stress-activated MAPK cascade (GO:0032872)	4.45	2	TLR4, AKT1
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	4.96	2	BAX, DLC1
positive regulation of axonogenesis (GO:0050772)	5.49	2	BRAF, EP300
regulation of lymphocyte proliferation (GO:0050670)	4.46	2	TLR4, CTNNB1
regulation of cell-matrix adhesion (GO:0001952)	5.21	2	PTPRJ, DLC1
epithelial cell proliferation (GO:0050673)	5.21	2	CCND1, BAX
cytokine production (GO:0001816)	5.42	2	TLR4, TLR2
negative regulation of cell morphogenesis involved in differentiation (GO:0010771)	4.96	2	DCC, CTNNB1
glucose metabolic process (GO:0006006)	4.94	2	PIK3CA, AKT1
negative regulation of cytokine production (GO:0001818)	4.4	2	KAT5, TLR4
positive regulation of glycoprotein metabolic process (GO:1903020)	6.73	2	EP300, CTNNB1
cellular response to lipoteichoic acid (GO:0071223)	7.53	2	TLR4, TLR2
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	4.88	2	BAX, DLC1
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	5.33	2	PTPRJ, AKT1
glycerolipid biosynthetic process (GO:0045017)	4.53	2	FGFR3, PIK3CA
macromolecular complex disassembly (GO:0032984)	4.53	2	APC, CTNNB1
regulation of generation of precursor metabolites and energy (GO:0043467)	5.24	2	PIK3CA, AKT1
response to gamma radiation (GO:0010332)	5.78	2	BAX, TP53
glucose transport (GO:0015758)	5.8	2	BRAF, AKT1
tissue morphogenesis (GO:0048729)	3.87	2	TRIM28, CTNNB1
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028)	5.94	2	BAX, TP53
T cell receptor signaling pathway (GO:0050852)	4.71	2	PTPRJ, PIK3CA
glial cell apoptotic process (GO:0034349)	7.65	2	BAX, TP53
ion transmembrane transport (GO:0034220)	3.08	2	MT-CO1, BAX
biological phase (GO:0044848)	4.37	2	CCND1, BUB1B
negative regulation of Ras protein signal transduction (GO:0046580)	6.07	2	DLC1, FLCN
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	5.84	2	FGFR3, PIK3CA
organelle localization (GO:0051640)	3.94	2	AURKA, CTNNB1
DNA recombination (GO:0006310)	4.39	2	RAD54B, MLH3
DNA damage checkpoint (GO:0000077)	5.37	2	CCND1, TP53
establishment of protein localization to membrane (GO:0090150)	4.14	2	BRAF, BAX
phospholipid biosynthetic process (GO:0008654)	4.39	2	FGFR3, PIK3CA
cellular response to ketone (GO:1901655)	5.44	2	EP300, AKT1
forebrain development (GO:0030900)	5.48	2	DLC1, CTNNB1
cellular response to peptide (GO:1901653)	4.52	2	AKT1, CTNNB1
mitotic spindle assembly checkpoint (GO:0007094)	6.78	2	APC, BUB1B
response to carbohydrate (GO:0009743)	4.62	2	EP300, PIK3CA
limb morphogenesis (GO:0035108)	5.05	2	BAX, CTNNB1
regulation of histone acetylation (GO:0035065)	5.74	2	EP300, FLCN
appendage morphogenesis (GO:0035107)	5.05	2	BAX, CTNNB1
negative regulation of protein kinase B signaling (GO:0051898)	6.12	2	PTPRJ, FLCN
regulation of focal adhesion assembly (GO:0051893)	5.84	2	PTPRJ, DLC1
regulation of ion transmembrane transport (GO:0034765)	3.77	2	BAX, AKT1
regulation of extent of cell growth (GO:0061387)	5.09	2	DCC, EP300
regulation of protein kinase B signaling (GO:0051896)	4.92	2	PTPRJ, FLCN
regulation of transmembrane transport (GO:0034762)	3.74	2	BAX, AKT1
hormone-mediated signaling pathway (GO:0009755)	4.66	2	KAT5, CTNNB1
regulation of actin filament bundle assembly (GO:0032231)	5.37	2	BRAF, DLC1
positive regulation of reactive oxygen species biosynthetic process (GO:1903428)	5.86	2	TLR4, AKT1
positive regulation of lipid metabolic process (GO:0045834)	4.88	2	FGFR3, AKT1
negative regulation of mitotic nuclear division (GO:0045839)	6.26	2	APC, BUB1B
single-organism behavior (GO:0044708)	3.79	2	BRAF, EP300
regulation of glycoprotein metabolic process (GO:1903018)	5.97	2	EP300, CTNNB1
response to cAMP (GO:0051591)	5.08	2	BRAF, EP300
positive regulation of neuron projection development (GO:0010976)	4.26	2	BRAF, EP300
intracellular steroid hormone receptor signaling pathway (GO:0030518)	5.47	2	KAT5, CTNNB1
regulation of calcium ion import (GO:0090279)	5.08	2	BAX, CTNNB1
platelet activation (GO:0030168)	4.96	2	AKT1, PIK3CA
positive regulation of interleukin-12 production (GO:0032735)	6.23	2	TLR4, TLR2
regulation of chemokine production (GO:0032642)	5.54	2	TLR4, TLR2
negative regulation of kidney development (GO:0090185)	6.9	2	FLCN, CTNNB1
regulation of interferon-beta production (GO:0032648)	5.92	2	TLR4, TLR2
mononuclear cell proliferation (GO:0032943)	5.32	2	BAX, TLR4
secretion by cell (GO:0032940)	3.59	2	TLR4, TLR2
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	5.67	2	TLR4, TLR2
regulation of mononuclear cell proliferation (GO:0032944)	4.45	2	TLR4, CTNNB1
regulation of ERBB signaling pathway (GO:1901184)	5.3	2	PTPRJ, AKT1
detection of molecule of bacterial origin (GO:0032490)	7.33	2	TLR4, TLR2
regulation of sister chromatid cohesion (GO:0007063)	6.9	2	AXIN2, CTNNB1
mitotic G1/S transition checkpoint (GO:0044819)	7.24	2	CCND1, TP53
regulation of cytokine secretion (GO:0050707)	4.74	2	TLR4, TLR2
cellular response to oxygen levels (GO:0071453)	4.97	2	TP53, AKT1
genitalia development (GO:0048806)	6.2	2	BAX, CTNNB1
positive regulation of proteasomal protein catabolic process (GO:1901800)	5.29	2	AURKA, AKT1
mitotic spindle checkpoint (GO:0071174)	6.68	2	APC, BUB1B
spindle assembly checkpoint (GO:0071173)	6.73	2	APC, BUB1B
maintenance of cell number (GO:0098727)	4.82	2	BRAF, CTNNB1
positive regulation of protein acetylation (GO:1901985)	6.15	2	KAT5, EP300
regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	6.78	2	TLR4, TLR2
Fc-epsilon receptor signaling pathway (GO:0038095)	4.84	2	NRAS, PIK3CA
Fc receptor signaling pathway (GO:0038093)	4.45	2	NRAS, PIK3CA
regulation of protein stability (GO:0031647)	4.33	2	AURKA, EP300
regulation of myelination (GO:0031641)	6.23	2	AKT1, CTNNB1
negative regulation of myeloid cell differentiation (GO:0045638)	5.42	2	TLR4, CTNNB1
positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)	6.2	2	CCND1, AKT1
regulation of myeloid cell differentiation (GO:0045637)	4.56	2	TLR4, CTNNB1
dephosphorylation (GO:0016311)	4.06	2	PTPRJ, PTPN12
positive regulation of cell growth (GO:0030307)	4.73	2	EP300, AKT1
tube formation (GO:0035148)	4.98	2	DLC1, CTNNB1
signaling (GO:0023052)	3.25	2	FGFR3, CTNNB1
axon guidance (GO:0007411)	4.44	2	DCC, NRAS
response to X-ray (GO:0010165)	6.33	2	CCND1, TP53
regulation of viral life cycle (GO:1903900)	4.6	2	EP300, TRIM28
regulation of centromeric sister chromatid cohesion (GO:0070602)	8.63	2	AXIN2, CTNNB1
negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	4.8	2	BUB1B, CTNNB1
regulation of DNA-templated transcription in response to stress (GO:0043620)	5.52	2	EP300, TP53
anaphase-promoting complex-dependent catabolic process (GO:0031145)	5.38	2	BUB1B, AURKA
regulation of kidney development (GO:0090183)	5.72	2	FLCN, CTNNB1
odontogenesis of dentin-containing tooth (GO:0042475)	5.52	2	BAX, CTNNB1
protein sumoylation (GO:0016925)	4.98	2	TP53, TRIM28
transmembrane transport (GO:0055085)	2.72	2	MT-CO1, BAX
positive regulation of leukocyte apoptotic process (GO:2000108)	6.33	2	BAX, TP53
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	TLR4, TLR2
apoptotic mitochondrial changes (GO:0008637)	5.7	2	BAX, AKT1
monosaccharide metabolic process (GO:0005996)	4.57	2	AKT1, PIK3CA
regulation of interleukin-6 production (GO:0032675)	5.08	2	TLR4, TLR2
myeloid cell differentiation (GO:0030099)	4.63	2	EP300, CTNNB1
hemopoiesis (GO:0030097)	5.07	2	FLCN, CTNNB1
negative regulation of proteolysis (GO:0045861)	3.98	2	EP300, AKT1
stimulatory C-type lectin receptor signaling pathway (GO:0002223)	5.09	2	EP300, NRAS
regulation of calcium ion transport (GO:0051924)	4.38	2	BAX, CTNNB1
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	5.1	2	TLR4, TLR2
mitotic DNA damage checkpoint (GO:0044773)	6.2	2	CCND1, TP53
mitotic DNA integrity checkpoint (GO:0044774)	6.04	2	CCND1, TP53
mitotic nuclear division (GO:0007067)	4.05	2	BUB1B, AURKA
cytokine secretion (GO:0050663)	6.07	2	TLR4, TLR2
morphogenesis of an epithelium (GO:0002009)	4.08	2	TRIM28, CTNNB1
intracellular receptor signaling pathway (GO:0030522)	4.6	2	KAT5, CTNNB1
androgen receptor signaling pathway (GO:0030521)	6.02	2	KAT5, CTNNB1
negative regulation of peptidase activity (GO:0010466)	4.22	2	EP300, AKT1
thymus development (GO:0048538)	5.88	2	BRAF, CTNNB1
regulation of cytokinesis (GO:0032465)	5.6	2	AURKA, FLCN
positive regulation of protein oligomerization (GO:0032461)	6.64	2	BAX, TP53
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	2	TLR4, AKT1
T cell apoptotic process (GO:0070231)	7.02	2	BAX, AKT1
regulation of osteoclast differentiation (GO:0045670)	5.59	2	TLR4, CTNNB1
negative regulation of osteoclast differentiation (GO:0045671)	6.51	2	TLR4, CTNNB1
B cell proliferation (GO:0042100)	6.12	2	BAX, TLR4
biomineral tissue development (GO:0031214)	5.41	2	FGFR3, AXIN2
DNA damage response, signal transduction resulting in transcription (GO:0042772)	7.02	2	KAT5, TP53
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)	6.33	2	EP300, TP53
cytoskeleton organization (GO:0007010)	3.22	2	AURKA, DLC1
cell part morphogenesis (GO:0032990)	3.99	2	DCC, BAX
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)	5.86	2	BAX, AKT1
response to lipoteichoic acid (GO:0070391)	7.53	2	TLR4, TLR2
regulation of tumor necrosis factor production (GO:0032680)	5.13	2	TLR4, TLR2
regulation of cell cycle G2/M phase transition (GO:1902749)	5.63	2	CCND1, TP53
monosaccharide transport (GO:0015749)	5.76	2	BRAF, AKT1
immune effector process (GO:0002252)	3.58	2	TLR4, PIK3CA
reciprocal DNA recombination (GO:0035825)	6.33	2	RAD54B, MLH3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of intracellular protein transport (GO:0033157)	-	3.8	0.0	AKT1, CCND1, AURKA, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, ODC1, TLR2
regulation of cytokine secretion (GO:0050707)	-	4.74	0.013	CCND1, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
hemostasis (GO:0007599)	NEW	4.5	0.001	APC, AKT1, NRAS, CCND1, AURKA, PIK3CA, ODC1, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.0	BAX, AKT1, NRAS, AURKA, CCND1, DLC1, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
regulation of secretion (GO:0051046)	-	3.2	0.0	BAX, TLR2, AKT1, PTPN12, AURKA, PLA2G2A, BUB1B, TP53, BRAF, ODC1, PIK3CA, CTNNB1, DLC1, DCC, KAT5, EP300, CCND1, TLR4
positive regulation of secretion (GO:0051047)	NEW	3.85	0.0	BAX, PTPN12, PLA2G2A, DLC1, TP53, PIK3CA, AKT1, TLR4, ODC1, EP300, CCND1, TLR2
mammary gland branching involved in thelarche (GO:0060744)	NEW	8.12	0.004	CCND1, TP53, AKT1
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.001	BAX, AKT1, NRAS, CCND1, AURKA, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
skeletal system development (GO:0001501)	-	4.49	0.0	AKT1, CCND1, BUB1B, TP53, FGFR3, PIK3CA, CTNNB1, KAT5, EP300, TLR2
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.005	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
ossification (GO:0001503)	-	4.86	0.001	CTNNB1, CCND1, AURKA, TP53, FGFR3, AXIN2, AKT1, KAT5
T cell activation (GO:0042110)	-	4.45	0.0	APC, BAX, CTNNB1, CCND1, TP53, AKT1, ODC1, EP300, BRAF, TLR2
ribonucleoside monophosphate metabolic process (GO:0009161)	NEW	4.62	0.027	MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, TLR4, CTNNB1, MLH3
regulation of stem cell differentiation (GO:2000736)	NEW	6.26	0.028	CTNNB1, CCND1, TP53, AXIN2, AKT1, EP300
cytokine-mediated signaling pathway (GO:0019221)	NEW	3.6	0.002	AKT1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
cellular response to stimulus (GO:0051716)	-	1.97	0.0	PDGFRL, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, FGFR3, TLR4, CCND1, MLH3
developmental growth (GO:0048589)	-	4.05	0.0	BAX, CTNNB1, PTPN12, AURKA, TP53, FGFR3, AKT1, KAT5, EP300, TLR4
response to external biotic stimulus (GO:0043207)	-	3.13	0.0	PLA2G2A, BAX, AKT1, DLC1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, ODC1, TLR2
regulation of organ formation (GO:0003156)	NEW	6.26	0.016	CCND1, EP300, AKT1, CTNNB1
response to hypoxia (GO:0001666)	-	4.13	0.0	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, PTPN12, KAT5, AKT1, ODC1, TLR2
positive regulation of cytoskeleton organization (GO:0051495)	-	4.58	0.005	APC, CTNNB1, CCND1, AURKA, AKT1, EP300, BRAF, TLR4
regulation of apoptotic signaling pathway (GO:2001233)	-	3.83	0.047	BAX, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, KAT5, EP300, TLR4
MAPK cascade (GO:0000165)	-	3.91	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, BRAF, TLR2
regulation of stress fiber assembly (GO:0051492)	-	5.49	0.003	CTNNB1, CCND1, AKT1, DCC, BRAF, DLC1
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
regulation of epithelial cell differentiation (GO:0030856)	-	4.96	0.0	APC, CTNNB1, PLA2G2A, TP53, BRAF, AKT1, KAT5, EP300, CCND1
labyrinthine layer development (GO:0060711)	NEW	7.53	0.019	AXIN2, EP300, TP53
positive regulation of epithelial cell differentiation (GO:0030858)	NEW	5.76	0.001	APC, CTNNB1, CCND1, TP53, AKT1, BRAF
regulation of mitosis (GO:0007088)	-	4.83	0.0	APC, BUB1B, CCND1, AURKA, TP53, FGFR3, AKT1, KAT5, EP300
regulation of intracellular transport (GO:0032386)	-	3.58	0.005	BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, ODC1, TLR2
blood coagulation (GO:0007596)	NEW	4.52	0.0	APC, AKT1, NRAS, CCND1, AURKA, PIK3CA, BRAF, TP53, CTNNB1, KAT5, EP300, ODC1, TLR4
regulation of DNA repair (GO:0006282)	-	5.4	0.0	APC, TP53, AXIN2, TRIM28, AKT1, EP300
DNA repair (GO:0006281)	-	3.59	0.026	BAX, CCND1, TRIM28, RAD54B, TP53, AKT1, KAT5, EP300, MLH3
negative regulation of cell death (GO:0060548)	-	2.95	0.0	BAX, TLR2, CTNNB1, NRAS, EP300, PLA2G2A, AURKA, TP53, BRAF, FGFR3, TRIM28, PTPN12, PIK3CA, DCC, KAT5, AKT1, CCND1, TLR4
regulation of protein kinase activity (GO:0045859)	-	3.15	0.025	APC, BAX, AKT1, NRAS, PTPN12, CCND1, AURKA, TP53, BRAF, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, ODC1, TLR2
germ cell development (GO:0007281)	-	4.75	0.016	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, TLR4
regulation of cell size (GO:0008361)	-	5.42	0.032	CCND1, TP53, AKT1, TLR4
cellular response to growth factor stimulus (GO:0071363)	-	4.27	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, TP53, BRAF, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, KAT5, TLR2
neuron projection guidance (GO:0097485)	-	4.43	0.001	AKT1, NRAS, PLA2G2A, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, DCC, KAT5, EP300, CCND1
regulation of phosphorylation (GO:0042325)	-	2.5	0.0	APC, BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, BRAF, FLCN
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of phosphorylation (GO:0042326)	-	3.7	0.02	APC, BAX, AKT1, NRAS, CCND1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
response to biotic stimulus (GO:0009607)	-	3.09	0.0	PLA2G2A, BAX, AKT1, DLC1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, ODC1, TLR2
epithelial cell migration (GO:0010631)	NEW	5.42	0.0	BAX, CCND1, PIK3CA, TP53, AKT1, EP300, TLR4
regulation of epithelial cell migration (GO:0010632)	-	4.62	0.001	CTNNB1, CCND1, MCC, RAD54B, TP53, AKT1, EP300, TLR4
response to monosaccharide (GO:0034284)	-	4.77	0.012	BAX, AKT1, CCND1, TP53, CTNNB1, EP300, TLR4
response to stress (GO:0006950)	-	1.8	0.0	APC, BAX, AKT1, NRAS, MLH3, PLA2G2A, TP53, FGFR3, TLR4, RAD54B, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, CCND1, TLR2
positive regulation of organelle organization (GO:0010638)	-	3.38	0.022	APC, BAX, CTNNB1, CCND1, AURKA, TP53, AKT1, KAT5, EP300, BRAF, TLR4
negative regulation of organelle organization (GO:0010639)	-	4.07	0.0	APC, BAX, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, AKT1, DCC, KAT5, EP300, FLCN
regulation of DNA replication (GO:0006275)	NEW	5.02	0.005	CCND1, PIK3CA, PTPRJ, TP53, AKT1, KAT5, TLR4
regulation of nuclear division (GO:0051783)	-	4.67	0.0	APC, BUB1B, CCND1, AURKA, TP53, FGFR3, AKT1, KAT5, EP300
positive regulation of cell division (GO:0051781)	NEW	5.35	0.001	APC, CTNNB1, CCND1, TP53, FGFR3, AKT1, EP300
epithelial cell differentiation involved in prostate gland development (GO:0060742)	NEW	7.53	0.009	CCND1, EP300, CTNNB1
negative regulation of nuclear division (GO:0051784)	-	5.94	0.0	APC, BUB1B, CCND1, AURKA, TP53, FGFR3, AKT1, KAT5
muscle cell differentiation (GO:0042692)	-	5.09	0.0	AKT1, NRAS, CCND1, TP53, CTNNB1, DCC, KAT5, EP300, TLR4
negative regulation of RNA metabolic process (GO:0051253)	-	2.66	0.002	APC, BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, FLCN
positive regulation of catabolic process (GO:0009896)	-	3.94	0.0	APC, BAX, CTNNB1, CCND1, AURKA, PIK3CA, TP53, TRIM28, AKT1, ODC1, EP300, TLR4
positive regulation of cellular component organization (GO:0051130)	-	2.68	0.0	APC, BAX, AKT1, NRAS, PTPN12, CCND1, AURKA, TP53, BRAF, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, AXIN2, KAT5, EP300, DLC1, TLR2
regulation of catabolic process (GO:0009894)	-	3.52	0.0	APC, BAX, TLR2, AKT1, DLC1, CCND1, AURKA, TP53, BRAF, PIK3CA, PTPRJ, TRIM28, PTPN12, TLR4, DCC, AXIN2, KAT5, CTNNB1, EP300, ODC1, FLCN
negative regulation of catabolic process (GO:0009895)	NEW	4.81	0.014	AKT1, CCND1, PIK3CA, TP53, CTNNB1, ODC1, EP300
cell differentiation in hindbrain (GO:0021533)	NEW	6.64	0.042	BAX, EP300, TP53, AKT1
positive regulation of metabolic process (GO:0009893)	-	1.74	0.0	APC, BAX, TLR2, AKT1, NRAS, DLC1, CCND1, AURKA, PIK3CA, FGFR3, TP53, AXIN2, TRIM28, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
positive regulation of canonical Wnt signaling pathway (GO:0090263)	NEW	4.95	0.002	CCND1, TP53, FGFR3, AKT1, EP300, TLR4
regulation of production of molecular mediator of immune response (GO:0002700)	NEW	5.1	0.014	CCND1, TP53, TLR4, AKT1, EP300, TLR2
response to reactive oxygen species (GO:0000302)	NEW	4.5	0.025	BAX, AKT1, CCND1, TP53, RAD54B, CTNNB1, TLR2
negative regulation of catenin import into nucleus (GO:0035414)	NEW	7.43	0.022	AXIN2, AKT1, CTNNB1
positive regulation of Wnt signaling pathway (GO:0030177)	-	4.7	0.0	AKT1, CCND1, TP53, FGFR3, AXIN2, TLR4, CTNNB1, ODC1, EP300, KAT5, TLR2
regulation of catenin import into nucleus (GO:0035412)	NEW	6.47	0.0	TP53, AXIN2, AKT1, CTNNB1, PIK3CA
lymphocyte proliferation (GO:0046651)	-	5.35	0.005	BAX, CTNNB1, TP53, AKT1, EP300, TLR4
positive regulation of protein serine/threonine kinase activity (GO:0071902)	-	4.06	0.0	BAX, CTNNB1, CCND1, AURKA, TP53, TLR4, PTPN12, PIK3CA, KAT5, AKT1, TLR2
positive regulation of protein transport (GO:0051222)	-	3.61	0.0	PTPN12, DLC1, CCND1, AURKA, PIK3CA, TP53, TRIM28, AKT1, TLR4, KAT5, ODC1, TLR2
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.0	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, FGFR3, PTPRJ, TLR4, PTPN12, PIK3CA, DCC, ODC1, AKT1, KAT5, TLR2
signal transduction by p53 class mediator (GO:0072331)	-	4.88	0.001	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300
negative regulation of Wnt signaling pathway (GO:0030178)	-	4.44	0.001	APC, AKT1, CCND1, MCC, AXIN2, TP53, CTNNB1, KAT5
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	-	5.76	0.0	BAX, AKT1, CCND1, TP53, CTNNB1, EP300
negative regulation of protein binding (GO:0032091)	-	5.36	0.001	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1
positive regulation of protein binding (GO:0032092)	NEW	5.42	0.02	CCND1, EP300, TRIM28, AKT1, TLR2
cell morphogenesis involved in differentiation (GO:0000904)	-	4.67	0.005	AKT1, PTPN12, CCND1, TP53, FGFR3, TRIM28, CTNNB1, EP300
positive regulation of transferase activity (GO:0051347)	-	3.31	0.0	BAX, AKT1, NRAS, PTPN12, CCND1, AURKA, TRIM28, BRAF, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, ODC1, TLR2
cell morphogenesis (GO:0000902)	-	4.35	0.006	AKT1, PTPN12, CCND1, TRIM28, TP53, FGFR3, PIK3CA, CTNNB1, EP300
positive regulation of hydrolase activity (GO:0051345)	-	2.91	0.0	APC, PLA2G2A, BAX, TLR2, CTNNB1, DLC1, CCND1, AURKA, TRIM28, BRAF, FGFR3, TP53, AXIN2, PIK3CA, AKT1, TLR4, DCC, KAT5, EP300, ODC1, FLCN
negative regulation of transferase activity (GO:0051348)	-	3.87	0.002	APC, AURKA, CCND1, BUB1B, PIK3CA, PTPRJ, TP53, AKT1, KAT5, EP300
positive regulation of MAPK cascade (GO:0043410)	-	3.57	0.0	BAX, AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, BRAF, TLR2
positive regulation of leukocyte migration (GO:0002687)	NEW	5.05	0.01	CCND1, TP53, TLR2, AKT1, TLR4, DLC1
positive regulation of immune system process (GO:0002684)	-	2.96	0.0	APC, BAX, CTNNB1, EP300, CCND1, DLC1, TP53, FGFR3, RAD54B, TLR4, PTPN12, PIK3CA, DCC, KAT5, AKT1, TLR2
regulation of leukocyte migration (GO:0002685)	NEW	4.72	0.008	CTNNB1, CCND1, DLC1, TP53, TLR4, AKT1, TLR2
regulation of T cell migration (GO:2000404)	NEW	6.55	0.019	TP53, CCND1, DLC1, AKT1
negative regulation of immune system process (GO:0002683)	-	3.85	0.0	BAX, AKT1, CCND1, DLC1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, TLR2
regulation of anatomical structure morphogenesis (GO:0022603)	-	2.79	0.0	APC, BAX, AKT1, PTPN12, AURKA, PLA2G2A, DLC1, TP53, BRAF, ODC1, AXIN2, PIK3CA, CTNNB1, DCC, PTPRJ, KAT5, EP300, CCND1, TLR4
regulation of execution phase of apoptosis (GO:1900117)	-	6.55	0.0	DLC1, KAT5, BAX, TP53, AKT1
regulation of muscle tissue development (GO:1901861)	NEW	5.07	0.013	CTNNB1, NRAS, CCND1, TP53, AKT1, KAT5, EP300
locomotory behavior (GO:0007626)	NEW	4.53	0.007	BAX, AKT1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300, DLC1
regulation of establishment of protein localization (GO:0070201)	-	3.02	0.0	BAX, AKT1, PTPN12, CCND1, AURKA, TRIM28, ODC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, DLC1, TLR2
positive regulation of reactive oxygen species metabolic process (GO:2000379)	-	5.29	0.042	KAT5, TP53, AKT1, TLR4
T cell differentiation in thymus (GO:0033077)	NEW	6.33	0.048	APC, EP300, TP53, CTNNB1
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.004	BAX, CTNNB1, PTPN12, PLA2G2A, TP53, FGFR3, RAD54B, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
regulation of insulin secretion (GO:0050796)	NEW	4.57	0.009	BAX, AKT1, CCND1, TP53, CTNNB1, ODC1, EP300, TLR4
cell cycle arrest (GO:0007050)	-	4.69	0.009	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, EP300
spindle organization (GO:0007051)	NEW	5.33	0.019	APC, AURKA, EP300, TP53, AKT1
macromolecule modification (GO:0043412)	-	1.73	0.047	AKT1, AURKA, CCND1, BUB1B, TRIM28, FGFR3, PTPRJ, TLR4, PTPN12, PIK3CA, KAT5, EP300, BRAF, TLR2
macromolecule methylation (GO:0043414)	NEW	4.42	0.036	AKT1, CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
epithelial cell fate commitment (GO:0072148)	NEW	7.65	0.039	FGFR3, CCND1, EP300
regulation of actin cytoskeleton organization (GO:0032956)	-	4.09	0.002	CTNNB1, CCND1, AURKA, TP53, DLC1, AKT1, DCC, EP300, BRAF, TLR4
chromosome segregation (GO:0007059)	NEW	5.06	0.035	APC, BUB1B, AURKA, TP53, AKT1
leukocyte differentiation (GO:0002521)	-	4.13	0.0	APC, AKT1, CCND1, AURKA, TP53, BRAF, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, ODC1, TLR4
positive regulation of protein secretion (GO:0050714)	NEW	4.39	0.019	PTPN12, CCND1, DLC1, TLR4, AKT1, EP300, TLR2
cellular response to cytokine stimulus (GO:0071345)	NEW	4.33	0.0	BAX, AKT1, DLC1, CCND1, AURKA, TP53, TRIM28, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, BRAF, TLR2
cellular response to interleukin-1 (GO:0071347)	NEW	5.42	0.0	CCND1, PIK3CA, TP53, AKT1, EP300, TLR2
digestive tract morphogenesis (GO:0048546)	NEW	6.78	0.005	FGFR3, CCND1, CTNNB1, AKT1
regulation of signal transduction (GO:0009966)	-	1.84	0.0	APC, BAX, TLR2, CTNNB1, NRAS, CCND1, DLC1, MCC, FGFR3, AXIN2, TP53, AKT1, TLR4, DCC, PTPRJ, EP300, BRAF, FLCN
neuron projection morphogenesis (GO:0048812)	NEW	4.34	0.021	APC, AKT1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.001	BAX, AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
regulation of dendrite morphogenesis (GO:0048814)	NEW	5.41	0.032	CCND1, EP300, PTPN12, AKT1, PIK3CA
positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	NEW	7.43	0.05	TP53, TLR2, TLR4
nucleoside phosphate metabolic process (GO:0006753)	NEW	3.71	0.0	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, KAT5, EP300, BRAF, MLH3
regulation of ceramide biosynthetic process (GO:2000303)	NEW	7.09	0.002	CCND1, TP53, AKT1
cellular response to alcohol (GO:0097306)	NEW	6.07	0.002	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300
regulation of developmental growth (GO:0048638)	-	4.04	0.001	AKT1, CCND1, AURKA, TP53, FGFR3, CTNNB1, DCC, KAT5, EP300
cellular response to metal ion (GO:0071248)	-	4.81	0.0	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, BRAF, TLR2
negative regulation of fibroblast proliferation (GO:0048147)	-	6.4	0.018	CCND1, BAX, TP53, AKT1
regulation of cytoskeleton organization (GO:0051493)	-	3.72	0.001	APC, AKT1, CCND1, AURKA, TP53, DLC1, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
regulation of fibroblast proliferation (GO:0048145)	-	5.32	0.0	BAX, AKT1, CCND1, TP53, PTPRJ, CTNNB1, EP300
cellular response to inorganic substance (GO:0071241)	-	4.67	0.0	CTNNB1, CCND1, TP53, PIK3CA, AKT1, TLR4, BRAF, TLR2
negative regulation of muscle organ development (GO:0048635)	NEW	6.17	0.007	CCND1, EP300, NRAS, AKT1
regulation of B cell proliferation (GO:0030888)	NEW	5.69	0.001	NRAS, CCND1, TLR4, AKT1, EP300, TLR2
negative regulation of cellular component organization (GO:0051129)	-	3.35	0.001	APC, BAX, TLR2, AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, FLCN
regulation of cellular component organization (GO:0051128)	-	2.01	0.0	APC, BAX, AKT1, AURKA, BRAF, BUB1B, TP53, FGFR3, AXIN2, DLC1, CTNNB1, DCC, PTPRJ, FLCN
somatic stem cell maintenance (GO:0035019)	NEW	5.52	0.0	APC, AKT1, PLA2G2A, TP53, BRAF, FGFR3, AXIN2, CTNNB1, KAT5, EP300, CCND1
regulation of protein catabolic process (GO:0042176)	-	3.83	0.0	APC, BAX, AKT1, PTPN12, CCND1, AURKA, PIK3CA, TP53, TRIM28, CTNNB1, DCC, ODC1, TLR4
response to UV (GO:0009411)	-	4.88	0.009	BAX, AKT1, CCND1, TP53, CTNNB1, EP300
negative regulation of mitotic cell cycle phase transition (GO:1901991)	-	4.82	0.0	APC, AKT1, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300
ERBB signaling pathway (GO:0038127)	-	5.36	0.0	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, ODC1, EP300, TLR4
glial cell differentiation (GO:0010001)	NEW	5.48	0.035	PTPRJ, TP53, EP300, AKT1, CTNNB1
response to organic cyclic compound (GO:0014070)	-	3.07	0.0	BAX, CTNNB1, NRAS, DLC1, PLA2G2A, BUB1B, TRIM28, TP53, BRAF, FGFR3, ODC1, AXIN2, PIK3CA, AKT1, TLR4, DCC, PTPRJ, KAT5, EP300, CCND1, TLR2
regulation of sphingolipid biosynthetic process (GO:0090153)	NEW	7.09	0.002	CCND1, TP53, AKT1
regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	NEW	6.64	0.007	TP53, CCND1, AKT1, CTNNB1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	-	3.12	0.01	APC, BAX, AKT1, DLC1, CCND1, AURKA, TP53, FGFR3, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, FLCN
nuclear division (GO:0000280)	-	3.85	0.0	DLC1, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, AKT1, KAT5, EP300, MLH3
regulation of cell development (GO:0060284)	-	3.01	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
regulation of nucleotide catabolic process (GO:0030811)	NEW	8.34	0.0	APC, AKT1, AURKA, CCND1, DLC1, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, PTPRJ, BRAF, FLCN
microtubule cytoskeleton organization involved in mitosis (GO:1902850)	NEW	6.17	0.05	AURKA, EP300, TP53
neurotrophin TRK receptor signaling pathway (GO:0048011)	NEW	6.96	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, ODC1, EP300, BRAF, TLR4
regulation of interleukin-6 production (GO:0032675)	-	5.08	0.019	CCND1, TP53, TLR4, AKT1, EP300, TLR2
cellular response to organic cyclic compound (GO:0071407)	-	3.93	0.0	TLR2, AKT1, NRAS, CCND1, TP53, AXIN2, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, PLA2G2A, TLR4
positive regulation of cell proliferation (GO:0008284)	-	3.01	0.0	TP53, RAD54B, KAT5, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
negative regulation of cell proliferation (GO:0008285)	-	3.26	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, PLA2G2A, MCC, AXIN2, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of body fluid levels (GO:0050878)	-	3.76	0.008	APC, AKT1, NRAS, CCND1, AURKA, TP53, ODC1, PIK3CA, CTNNB1, KAT5, EP300, PLA2G2A, TLR4
cell proliferation (GO:0008283)	-	3.23	0.001	BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, DCC, PTPRJ, KAT5, EP300, TLR4
neurological system process (GO:0050877)	-	2.64	0.002	BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, BRAF, TP53, PTPRJ, TRIM28, CTNNB1, DCC, KAT5, EP300, ODC1, TLR4
regulation of microtubule-based process (GO:0032886)	-	4.79	0.002	APC, CTNNB1, AURKA, TP53, AKT1, KAT5, EP300
positive regulation of T cell activation (GO:0050870)	-	4.39	0.019	BAX, PTPN12, CCND1, PIK3CA, TP53, AKT1, KAT5, DLC1
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.002	APC, BAX, AKT1, DLC1, MLH3, CCND1, AURKA, TP53, RAD54B, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, FLCN
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)	NEW	5.78	0.001	TP53, EP300, AKT1, CTNNB1, KAT5
regulation of hormone secretion (GO:0046883)	NEW	4.18	0.008	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300, ODC1, TLR4
defense response to other organism (GO:0098542)	-	3.75	0.0	BAX, CTNNB1, CCND1, DLC1, TP53, PIK3CA, AKT1, TLR4, KAT5, EP300, PLA2G2A, TLR2
regulation of cellular carbohydrate metabolic process (GO:0010675)	NEW	4.81	0.043	BAX, NRAS, CCND1, TRIM28, TP53, AKT1, KAT5
cell-cell junction organization (GO:0045216)	-	4.66	0.022	APC, AKT1, TP53, DLC1, CTNNB1, EP300, FLCN
cellular lipid metabolic process (GO:0044255)	-	2.92	0.039	BAX, CTNNB1, DLC1, PLA2G2A, AURKA, TP53, ODC1, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
palate development (GO:0060021)	NEW	5.38	0.01	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300
response to oxidative stress (GO:0006979)	-	3.9	0.006	BAX, CTNNB1, EP300, CCND1, TP53, RAD54B, TLR4, PTPN12, AKT1, TLR2
regulation of chromosome segregation (GO:0051983)	-	5.38	0.04	APC, AXIN2, PTPRJ, CTNNB1
regulation of cell-cell adhesion (GO:0022407)	-	3.79	0.0	CTNNB1, EP300, PLA2G2A, TP53, BRAF, PIK3CA, PTPN12, AKT1, CCND1
cell cycle process (GO:0022402)	-	2.75	0.0	APC, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, ODC1, MLH3
peptidyl-serine phosphorylation (GO:0018105)	-	4.82	0.004	CTNNB1, CCND1, AURKA, TP53, AKT1, DLC1
cellular response to nitrogen compound (GO:1901699)	-	3.79	0.0	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, ODC1, TLR2
negative regulation of growth (GO:0045926)	-	4.24	0.0	BAX, TLR2, AKT1, CCND1, AURKA, TP53, FGFR3, PTPRJ, TRIM28, CTNNB1, TLR4, DCC, KAT5, EP300, FLCN
positive regulation of growth (GO:0045927)	-	4.25	0.006	AURKA, PLA2G2A, BUB1B, TP53, AKT1, KAT5, EP300, CCND1, TLR4
regulation of cellular localization (GO:0060341)	-	3.03	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, TLR4, ODC1, CCND1
cell projection organization (GO:0030030)	-	3.14	0.001	APC, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, DCC, ODC1, EP300, KAT5, TLR4
regulation of metabolic process (GO:0019222)	-	1.02	0.006	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
apoptotic signaling pathway (GO:0097190)	-	4.12	0.001	BAX, AKT1, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, EP300, FLCN
extrinsic apoptotic signaling pathway (GO:0097191)	-	5.16	0.001	BAX, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4
actin cytoskeleton organization (GO:0030036)	NEW	4.1	0.011	CTNNB1, NRAS, BRAF, DLC1, PIK3CA, TP53, AKT1, EP300, TLR4
intrinsic apoptotic signaling pathway (GO:0097193)	-	4.69	0.0	BAX, AKT1, CCND1, TP53, PIK3CA, CTNNB1, EP300, FLCN
glucose homeostasis (GO:0042593)	-	4.6	0.003	BAX, CTNNB1, NRAS, CCND1, TP53, PTPRJ, AKT1, EP300
leukocyte migration (GO:0050900)	-	4.19	0.002	CTNNB1, NRAS, CCND1, TP53, TLR4, PTPN12, PIK3CA, AKT1, TLR2
cell junction organization (GO:0034330)	-	4.51	0.049	APC, AKT1, TP53, DLC1, CTNNB1, EP300, FLCN
regulation of mitochondrion organization (GO:0010821)	-	4.34	0.033	BAX, CCND1, TP53, AKT1, KAT5, FLCN
negative regulation of mitochondrion organization (GO:0010823)	-	6.07	0.012	CCND1, FLCN, TP53, AKT1
lens morphogenesis in camera-type eye (GO:0002089)	NEW	7.16	0.002	FGFR3, CCND1, AURKA, CTNNB1
lens development in camera-type eye (GO:0002088)	NEW	6.09	0.001	TP53, CCND1, EP300, CTNNB1, AKT1
fat cell differentiation (GO:0045444)	-	5.02	0.003	BAX, AKT1, CCND1, TP53, CTNNB1, EP300, TLR4
cell death (GO:0008219)	-	3.05	0.002	APC, BAX, TLR2, CTNNB1, EP300, AURKA, CCND1, BUB1B, DLC1, TP53, FGFR3, PIK3CA, PTPRJ, TRIM28, PTPN12, TLR4, DCC, ODC1, AKT1, KAT5, MLH3
multicellular organismal development (GO:0007275)	-	2.54	0.025	APC, AKT1, CCND1, TP53, FGFR3, ODC1, TRIM28, CTNNB1, KAT5, EP300, BRAF, TLR4
cell division (GO:0051301)	-	3.68	0.006	CTNNB1, BUB1B, CCND1, AURKA, TP53, AKT1, EP300
response to estradiol (GO:0032355)	-	4.73	0.0	BAX, CTNNB1, CCND1, TP53, FGFR3, AKT1, KAT5, EP300, TLR4
regulation of immune system process (GO:0002682)	-	2.5	0.009	APC, BAX, AKT1, NRAS, PIK3CA, FGFR3, PTPRJ, FLCN, CTNNB1, TLR4, TLR2
regulation of cysteine-type endopeptidase activity (GO:2000116)	-	4.37	0.001	BAX, CTNNB1, DLC1, CCND1, AURKA, TP53, TLR4, AKT1, FLCN
response to lipid (GO:0033993)	-	3.11	0.0	BAX, TLR2, AKT1, PLA2G2A, AURKA, TP53, BRAF, PTPRJ, TRIM28, CTNNB1, PIK3CA, DCC, ODC1, CCND1, EP300, KAT5, TLR4
response to toxic substance (GO:0009636)	NEW	4.88	0.0	BAX, AKT1, CCND1, TP53, ODC1, PTPRJ, CTNNB1, KAT5, EP300, BRAF, TLR2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	-	2.6	0.0	APC, BAX, AKT1, NRAS, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, BRAF, FLCN
regulation of cell division (GO:0051302)	-	4.88	0.0	APC, AKT1, AURKA, CCND1, BUB1B, TP53, FGFR3, CTNNB1, KAT5, EP300, FLCN
positive regulation of apoptotic process (GO:0043065)	-	3.38	0.0	APC, BAX, PIK3CA, CTNNB1, EP300, CCND1, AURKA, TP53, FGFR3, TRIM28, PTPN12, TLR4, DCC, KAT5, AKT1, PLA2G2A, FLCN
regulation of leukocyte proliferation (GO:0070663)	-	4.4	0.001	AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
regulation of nervous system development (GO:0051960)	-	3.1	0.0	APC, AKT1, PTPN12, CCND1, AURKA, TRIM28, BRAF, FGFR3, ODC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, DLC1, TLR2
negative regulation of leukocyte proliferation (GO:0070664)	NEW	5.52	0.027	CCND1, EP300, DLC1, TP53, TLR4
extracellular structure organization (GO:0043062)	NEW	4.0	0.002	BAX, PTPN12, CCND1, AURKA, TP53, PIK3CA, CTNNB1, KAT5, AKT1, BRAF, TLR4
regulation of cell motility (GO:2000145)	-	3.16	0.0	AKT1, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, PLA2G2A, MCC, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.0	BAX, TLR2, AKT1, NRAS, PTPN12, PLA2G2A, AURKA, TP53, BRAF, FGFR3, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, CCND1, TLR4
positive regulation of programmed cell death (GO:0043068)	-	3.38	0.0	APC, BAX, PIK3CA, CTNNB1, EP300, CCND1, AURKA, TP53, FGFR3, TRIM28, PTPN12, TLR4, DCC, KAT5, AKT1, PLA2G2A, FLCN
negative regulation of canonical Wnt signaling pathway (GO:0090090)	-	4.63	0.001	APC, CTNNB1, CCND1, MCC, AXIN2, TP53, AKT1
response to retinoic acid (GO:0032526)	NEW	5.02	0.022	CTNNB1, CCND1, TP53, AKT1, KAT5, EP300, TLR2
negative regulation of protein kinase activity (GO:0006469)	-	4.29	0.02	APC, CCND1, PIK3CA, PTPRJ, TP53, AKT1, KAT5, EP300
mitotic cell cycle (GO:0000278)	NEW	5.92	0.0	APC, AURKA, CCND1, BUB1B, TP53, TRIM28, AKT1, KAT5, EP300, ODC1, DLC1
regulation of lipid metabolic process (GO:0019216)	-	4.08	0.0	AKT1, CCND1, TRIM28, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
innate immune response (GO:0045087)	-	3.55	0.006	APC, CTNNB1, NRAS, DLC1, EP300, CCND1, AURKA, TRIM28, FGFR3, TP53, PIK3CA, PTPN12, TLR4, DCC, ODC1, AKT1, TLR2
protein complex assembly (GO:0006461)	-	2.78	0.0	APC, MT-CO1, AKT1, PTPN12, AURKA, CCND1, BUB1B, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, DLC1, KAT5, EP300, BRAF, TLR4
negative regulation of intracellular protein transport (GO:0090317)	NEW	5.23	0.005	CTNNB1, TP53, AXIN2, AKT1, EP300, TLR4
positive regulation of intracellular protein transport (GO:0090316)	-	4.19	0.0	CCND1, AURKA, TRIM28, TP53, TLR4, AKT1, KAT5, ODC1, TLR2
cellular protein modification process (GO:0006464)	-	1.79	0.024	PTPN12, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, PTPRJ, TRIM28, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
single-organism developmental process (GO:0044767)	-	1.49	0.0	AKT1, TP53, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
multi-organism cellular process (GO:0044764)	-	3.14	0.001	BAX, AKT1, CCND1, DLC1, TRIM28, TP53, RAD54B, PTPRJ, PIK3CA, CTNNB1, KAT5, EP300, BRAF, TLR4
single-organism cellular process (GO:0044763)	-	0.65	0.021	MT-CO1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
positive regulation of peptidase activity (GO:0010952)	-	4.7	0.008	BAX, CCND1, TP53, DLC1, AKT1, BRAF, TLR4
response to oxygen-containing compound (GO:1901700)	-	2.57	0.018	AKT1, NRAS, CCND1, PIK3CA, FGFR3, TLR4, CTNNB1, KAT5, BRAF, TLR2
positive regulation of cellular component movement (GO:0051272)	-	3.71	0.0	APC, PLA2G2A, BAX, AKT1, PTPN12, CCND1, DLC1, TP53, TLR4, RAD54B, TRIM28, CTNNB1, PIK3CA, EP300, BRAF, TLR2
negative regulation of locomotion (GO:0040013)	-	4.22	0.0	AKT1, CCND1, DLC1, MCC, PTPRJ, TP53, CTNNB1, KAT5, EP300, BRAF, FLCN
regulation of cellular component movement (GO:0051270)	-	3.08	0.0	AKT1, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, PLA2G2A, MCC, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
positive regulation of endothelial cell migration (GO:0010595)	NEW	5.52	0.008	TP53, CCND1, EP300, AKT1, CTNNB1
positive regulation of locomotion (GO:0040017)	-	3.71	0.0	APC, BAX, PIK3CA, AKT1, PLA2G2A, DLC1, TP53, BRAF, RAD54B, TRIM28, PTPN12, TLR4, DCC, CTNNB1, EP300, CCND1, TLR2
anatomical structure development (GO:0048856)	-	1.58	0.009	APC, BAX, AKT1, PTPN12, CCND1, DLC1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, PTPRJ, ODC1, EP300, FLCN
positive regulation of JNK cascade (GO:0046330)	NEW	4.98	0.042	KAT5, AKT1, TP53, PIK3CA, TLR4
ribose phosphate metabolic process (GO:0019693)	NEW	4.06	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, MLH3
negative regulation of leukocyte differentiation (GO:1902106)	-	5.3	0.012	CTNNB1, CCND1, TP53, AKT1, EP300, TLR4
phosphate-containing compound metabolic process (GO:0006796)	-	2.16	0.0	MT-CO1, TLR2, PTPN12, NRAS, AURKA, CCND1, BUB1B, TRIM28, BRAF, FGFR3, RAD54B, PTPRJ, PIK3CA, AKT1, TLR4, PLA2G2A, MLH3
regulation of multicellular organismal development (GO:2000026)	-	2.31	0.0	APC, BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, TLR2, CTNNB1, TLR4, DCC, FLCN
regulation of peptidyl-lysine acetylation (GO:2000756)	-	5.67	0.0	CCND1, TP53, TLR4, AKT1, EP300, FLCN
phosphorus metabolic process (GO:0006793)	-	2.15	0.0	MT-CO1, TLR2, PTPN12, NRAS, AURKA, CCND1, BUB1B, TRIM28, BRAF, FGFR3, RAD54B, PTPRJ, PIK3CA, AKT1, TLR4, PLA2G2A, MLH3
negative regulation of viral process (GO:0048525)	NEW	5.07	0.002	CCND1, TP53, TRIM28, AKT1, EP300, TLR4
regulation of nucleotide metabolic process (GO:0006140)	NEW	4.38	0.0	APC, TLR2, AKT1, AURKA, CCND1, DLC1, TP53, PIK3CA, AXIN2, TRIM28, CTNNB1, TLR4, DCC, PTPRJ, KAT5, BRAF, FLCN
positive regulation of interleukin-8 production (GO:0032757)	-	5.92	0.007	AKT1, PIK3CA, TLR2, TLR4
negative regulation of cellular process (GO:0048523)	-	1.41	0.0	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, CCND1
positive regulation of cellular process (GO:0048522)	-	1.3	0.0	TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of chromosome organization (GO:0033044)	-	4.11	0.0	AKT1, CCND1, AURKA, TP53, AXIN2, TLR4, CTNNB1, PTPRJ, KAT5, EP300, FLCN
protein localization (GO:0008104)	-	2.36	0.001	AKT1, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, TLR4, PTPRJ, KAT5, EP300, MLH3
regulation of T cell differentiation in thymus (GO:0033081)	NEW	6.47	0.017	FGFR3, CCND1, AKT1, CTNNB1
regulation of reproductive process (GO:2000241)	-	4.88	0.001	APC, CTNNB1, CCND1, AURKA, TP53, AKT1, EP300
activation of protein kinase activity (GO:0032147)	-	4.08	0.0	CTNNB1, NRAS, CCND1, AURKA, TP53, ODC1, TLR4, PTPN12, PIK3CA, KAT5, AKT1, BRAF, TLR2
behavior (GO:0007610)	-	3.47	0.001	BAX, AKT1, NRAS, DLC1, CCND1, BUB1B, PIK3CA, ODC1, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
learning or memory (GO:0007611)	-	4.33	0.0	BAX, AKT1, NRAS, CCND1, TP53, ODC1, CTNNB1, KAT5, EP300, BRAF, TLR4
positive regulation of defense response (GO:0031349)	-	3.83	0.0	PTPN12, PLA2G2A, TP53, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
muscle system process (GO:0003012)	NEW	4.18	0.011	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, DCC, EP300, TLR2
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.001	BAX, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, PIK3CA, PTPN12, KAT5, EP300, BRAF
negative regulation of neuron apoptotic process (GO:0043524)	-	4.82	0.0	BAX, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, BRAF
positive regulation of neuron apoptotic process (GO:0043525)	-	5.88	0.0	BAX, CCND1, TP53, FGFR3, AKT1, EP300
cell surface receptor signaling pathway (GO:0007166)	-	2.09	0.0	APC, BAX, AKT1, NRAS, EP300, PDGFRL, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, MCC, CCND1, TLR2
enzyme linked receptor protein signaling pathway (GO:0007167)	-	3.24	0.0	APC, BAX, AKT1, NRAS, PTPN12, AURKA, CCND1, DLC1, TP53, BRAF, FGFR3, PDGFRL, PTPRJ, PIK3CA, CTNNB1, DCC, ODC1, EP300, KAT5, TLR4
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	-	3.54	0.0	APC, BAX, AKT1, NRAS, DLC1, CCND1, AURKA, PIK3CA, BRAF, FGFR3, ODC1, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, PDGFRL, TLR4
myeloid leukocyte differentiation (GO:0002573)	NEW	5.23	0.005	CTNNB1, AURKA, TP53, AKT1, EP300, TLR4
regulation of cell projection organization (GO:0031344)	-	3.38	0.0	APC, BAX, AKT1, AURKA, CCND1, DLC1, TP53, AXIN2, PIK3CA, PTPN12, DCC, KAT5, EP300, BRAF, TLR4
regulation of defense response (GO:0031347)	-	3.11	0.0	APC, BAX, PTPN12, PLA2G2A, TP53, BRAF, FGFR3, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
positive regulation of cell projection organization (GO:0031346)	-	3.99	0.0	APC, BAX, AKT1, DLC1, CCND1, BUB1B, TP53, PIK3CA, PTPN12, DCC, EP300, BRAF, TLR4
leukocyte proliferation (GO:0070661)	-	5.25	0.009	BAX, CTNNB1, TP53, AKT1, EP300, TLR4
positive regulation of inflammatory response (GO:0050729)	-	4.98	0.01	PTPN12, CCND1, TLR4, AKT1, PLA2G2A, TLR2
negative regulation of cell cycle (GO:0045786)	-	3.67	0.0	APC, AKT1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, EP300
rhythmic process (GO:0048511)	-	4.02	0.019	APC, BAX, AKT1, CCND1, TP53, CTNNB1, KAT5, EP300, MLH3
positive regulation of cell adhesion (GO:0045785)	-	3.79	0.0	APC, AURKA, CTNNB1, EP300, CCND1, PLA2G2A, TP53, PTPRJ, TLR4, PTPN12, PIK3CA, KAT5, AKT1, BRAF, FLCN
MyD88-independent toll-like receptor signaling pathway (GO:0002756)	NEW	6.33	0.008	TP53, CCND1, AKT1, TLR2, TLR4
negative regulation of kinase activity (GO:0033673)	-	4.22	0.003	APC, CCND1, AURKA, PIK3CA, PTPRJ, TP53, AKT1, KAT5, EP300
cell activation involved in immune response (GO:0002263)	NEW	4.86	0.005	AKT1, TP53, TLR4, CTNNB1, KAT5, EP300, TLR2
response to epidermal growth factor (GO:0070849)	NEW	6.29	0.031	BRAF, EP300, TP53, AKT1
response to growth factor (GO:0070848)	-	4.14	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, ODC1, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
regulation of neuron differentiation (GO:0045664)	-	3.39	0.0	APC, AKT1, PTPN12, AURKA, CCND1, DLC1, PIK3CA, AXIN2, TP53, CTNNB1, DCC, PTPRJ, EP300, BRAF, TLR4
regulation of osteoblast differentiation (GO:0045667)	-	4.99	0.0	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.0	BAX, AKT1, NRAS, PTPN12, CCND1, AURKA, TRIM28, BRAF, FGFR3, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, PLA2G2A, TLR2
positive regulation of molecular function (GO:0044093)	-	2.23	0.008	BAX, NRAS, CCND1, DLC1, PIK3CA, FGFR3, AXIN2, TLR4, AKT1, EP300, BRAF, TLR2
negative regulation of molecular function (GO:0044092)	-	2.74	0.0	APC, PLA2G2A, BAX, TLR2, AKT1, AURKA, CCND1, BUB1B, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, ODC1, FLCN
macromolecule localization (GO:0033036)	-	2.34	0.001	AKT1, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, TLR4, PTPRJ, KAT5, EP300, MLH3
negative regulation of osteoblast differentiation (GO:0045668)	NEW	6.02	0.0	CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300
epithelial cell development (GO:0002064)	NEW	4.92	0.004	BAX, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300
columnar/cuboidal epithelial cell differentiation (GO:0002065)	NEW	5.84	0.024	TP53, CCND1, EP300, AKT1, CTNNB1
regulation of small GTPase mediated signal transduction (GO:0051056)	-	4.08	0.0	AKT1, NRAS, DLC1, CCND1, TRIM28, TP53, PIK3CA, CTNNB1, DCC, FLCN
positive regulation of DNA metabolic process (GO:0051054)	-	4.49	0.0	BAX, CCND1, TRIM28, TP53, AKT1, KAT5, EP300, TLR4
purine ribonucleoside monophosphate metabolic process (GO:0009167)	NEW	4.7	0.017	MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, TLR4, CTNNB1, MLH3
chemotaxis (GO:0006935)	NEW	4.04	0.0	BAX, CTNNB1, CCND1, TP53, FGFR3, PTPRJ, TLR4, PTPN12, PIK3CA, AKT1, TLR2
negative regulation of transport (GO:0051051)	-	3.6	0.0	CTNNB1, PLA2G2A, TP53, BRAF, ODC1, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
T cell differentiation (GO:0030217)	-	5.11	0.005	APC, CTNNB1, CCND1, TP53, AKT1, EP300, BRAF
ATP metabolic process (GO:0046034)	NEW	4.98	0.01	MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, TLR4, CTNNB1, MLH3
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123)	NEW	8.63	0.007	CCND1, TLR2, TP53, AKT1, TLR4
negative regulation of small GTPase mediated signal transduction (GO:0051058)	-	6.04	0.0	TP53, FLCN, AKT1, PIK3CA, DCC, DLC1
monocarboxylic acid metabolic process (GO:0032787)	NEW	3.57	0.025	BAX, CTNNB1, PLA2G2A, TP53, ODC1, TLR2, AKT1, KAT5, EP300, BRAF, TLR4
single organism reproductive process (GO:0044702)	-	2.73	0.001	BAX, TLR2, AKT1, CCND1, AURKA, TRIM28, BRAF, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, ODC1, EP300, KAT5, MLH3
response to metal ion (GO:0010038)	-	3.91	0.002	MT-CO1, AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, BRAF, TLR2
regulation of response to DNA damage stimulus (GO:2001020)	-	4.74	0.0	APC, CTNNB1, CCND1, TRIM28, AXIN2, TP53, AKT1, KAT5, EP300, TLR4
regulation of synaptic transmission (GO:0050804)	NEW	4.09	0.0	BAX, NRAS, DLC1, CCND1, BUB1B, PIK3CA, TP53, AKT1, KAT5, BRAF, TLR4
response to other organism (GO:0051707)	-	3.48	0.0	BAX, TLR2, AKT1, CCND1, DLC1, TP53, ODC1, PIK3CA, CTNNB1, KAT5, EP300, PLA2G2A, TLR4
response to organic substance (GO:0010033)	-	2.2	0.001	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
regulation of transcription factor import into nucleus (GO:0042990)	-	5.16	0.0	AURKA, TRIM28, TLR4, AKT1, KAT5, ODC1, TLR2
organonitrogen compound catabolic process (GO:1901565)	NEW	3.91	0.001	BAX, TLR2, AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, EP300, BRAF, MLH3
stem cell maintenance (GO:0019827)	-	4.83	0.0	APC, AKT1, NRAS, CCND1, TP53, BRAF, FGFR3, AXIN2, CTNNB1, KAT5, EP300, PLA2G2A
peptidyl-serine modification (GO:0018209)	-	4.72	0.0	CTNNB1, CCND1, AURKA, TP53, DLC1, AKT1, TLR4
negative regulation of signaling (GO:0023057)	-	2.65	0.0	APC, BAX, TLR2, AKT1, NRAS, AURKA, CCND1, DLC1, TP53, FGFR3, TLR4, AXIN2, MCC, CTNNB1, PIK3CA, DCC, PTPRJ, KAT5, EP300, BRAF, FLCN
mitotic spindle organization (GO:0007052)	NEW	6.29	0.0	BUB1B, AURKA, EP300, TP53, AKT1
response to nutrient levels (GO:0031667)	-	3.77	0.018	BAX, TLR2, AKT1, CCND1, TP53, TLR4, CTNNB1, KAT5, EP300, FLCN
protein ubiquitination (GO:0016567)	-	3.28	0.004	BAX, CTNNB1, CCND1, AURKA, TRIM28, RAD54B, TP53, AKT1, EP300, BRAF, TLR4
regulation of proteasomal protein catabolic process (GO:0061136)	-	4.78	0.0	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, EP300
cellular response to carbohydrate stimulus (GO:0071322)	-	5.52	0.021	AKT1, CCND1, EP300, TP53, TLR2
chromatin modification (GO:0016568)	-	4.06	0.044	APC, CTNNB1, AURKA, CCND1, BUB1B, TP53, AKT1, KAT5, EP300, TLR4
negative regulation of striated muscle tissue development (GO:0045843)	NEW	6.23	0.004	CCND1, EP300, NRAS, AKT1
myeloid leukocyte activation (GO:0002274)	NEW	5.15	0.019	PIK3CA, TLR4, AKT1, ODC1, EP300, TLR2
regulation of purine nucleotide catabolic process (GO:0033121)	NEW	8.34	0.0	APC, AKT1, DLC1, CCND1, AURKA, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, BRAF, FLCN
leukocyte activation (GO:0045321)	-	3.76	0.0	APC, BAX, AKT1, CCND1, DLC1, TP53, TLR4, TRIM28, CTNNB1, PIK3CA, ODC1, KAT5, EP300, BRAF, TLR2
negative regulation of gene expression (GO:0010629)	-	2.48	0.001	APC, BAX, AKT1, DLC1, CCND1, AURKA, TP53, FGFR3, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, BRAF, FLCN
positive regulation of gene expression (GO:0010628)	-	2.35	0.046	CTNNB1, BRAF, TRIM28, TP53, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
neuron migration (GO:0001764)	-	5.0	0.0	BAX, AKT1, CCND1, AURKA, PIK3CA, TP53, CTNNB1, DCC, EP300
nucleoside monophosphate metabolic process (GO:0009123)	NEW	4.54	0.032	MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, TLR4, CTNNB1, MLH3
developmental programmed cell death (GO:0010623)	NEW	7.33	0.0	BAX, AKT1, CCND1, TP53, CTNNB1, EP300
regulation of JNK cascade (GO:0046328)	-	4.65	0.0	AKT1, CCND1, AURKA, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, TLR2
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.001	BAX, AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
positive regulation of cell communication (GO:0010647)	-	2.41	0.002	BAX, TLR2, NRAS, BRAF, TP53, FGFR3, PTPRJ, TLR4, CTNNB1, DCC, FLCN
embryonic epithelial tube formation (GO:0001838)	NEW	6.4	0.008	TP53, EP300, AKT1, CTNNB1
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.001	APC, BAX, NRAS, BRAF, TRIM28, FGFR3, AXIN2, TP53, CTNNB1, DCC, EP300, DLC1
immune response-regulating signaling pathway (GO:0002764)	-	3.72	0.0	BAX, AKT1, NRAS, CCND1, DLC1, TP53, FGFR3, TLR4, PTPN12, PIK3CA, DCC, EP300, TLR2
regulation of GTPase activity (GO:0043087)	-	3.21	0.0	APC, AKT1, DLC1, CCND1, AURKA, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, PTPRJ, BRAF, FLCN
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	-	5.26	0.002	BAX, CCND1, TP53, TLR4, AKT1, DLC1
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4, ODC1, EP300, BRAF, TLR2
cell cycle (GO:0007049)	-	3.14	0.0	APC, DLC1, AURKA, CCND1, BUB1B, TRIM28, PTPRJ, TP53, AKT1, ODC1, EP300, KAT5, TLR4
transcription initiation from RNA polymerase II promoter (GO:0006367)	NEW	4.7	0.015	AKT1, CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300
regulation of phosphorus metabolic process (GO:0051174)	-	2.35	0.0	APC, BAX, AKT1, NRAS, CCND1, DLC1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, BRAF, FLCN
regulation of protein localization (GO:0032880)	-	2.88	0.0	APC, BAX, TLR2, PTPN12, NRAS, DLC1, EP300, CCND1, AURKA, TP53, PIK3CA, AXIN2, TRIM28, CTNNB1, TLR4, DCC, PTPRJ, KAT5, AKT1, ODC1, FLCN
G-protein coupled receptor signaling pathway (GO:0007186)	-	2.64	0.013	BAX, AKT1, NRAS, CCND1, TP53, BRAF, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, PDGFRL, TLR2
response to tumor necrosis factor (GO:0034612)	NEW	4.93	0.0	CCND1, PIK3CA, TP53, TRIM28, AKT1, KAT5, EP300, BRAF
cellular protein localization (GO:0034613)	-	3.11	0.003	AKT1, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, PTPRJ, EP300, TLR4
organ morphogenesis (GO:0009887)	-	3.55	0.001	BAX, AKT1, CCND1, TP53, FGFR3, AXIN2, DLC1, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
apoptotic process (GO:0006915)	-	3.14	0.0	APC, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, PTPRJ, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, DLC1, TLR2
response to radiation (GO:0009314)	-	3.69	0.012	BAX, NRAS, CCND1, TP53, AKT1, KAT5, BRAF
regulation of developmental process (GO:0050793)	-	2.1	0.0	APC, PLA2G2A, BAX, TLR2, AKT1, NRAS, DLC1, CCND1, AURKA, TP53, FGFR3, AXIN2, TLR4, CTNNB1, DCC, BRAF, FLCN
regulation of viral process (GO:0050792)	-	3.89	0.011	CTNNB1, CCND1, TRIM28, TP53, AKT1, EP300, TLR4
regulation of catalytic activity (GO:0050790)	-	1.97	0.004	APC, BAX, NRAS, DLC1, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, AKT1, PTPRJ, BRAF, TLR4
tissue development (GO:0009888)	-	3.27	0.004	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, FGFR3, AXIN2, TLR4, PTPN12, DCC, KAT5, AKT1, FLCN
cellular response to radiation (GO:0071478)	-	4.81	0.0	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, EP300, BRAF
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	APC, BAX, TLR2, AKT1, NRAS, CCND1, AURKA, MCC, FGFR3, PIK3CA, AXIN2, TP53, CTNNB1, TLR4, DCC, KAT5, EP300, FLCN
regulation of cellular response to growth factor stimulus (GO:0090287)	-	4.29	0.0	AKT1, NRAS, CCND1, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, FLCN
positive regulation of neuron death (GO:1901216)	-	5.52	0.0	BAX, CCND1, TP53, FGFR3, AKT1, EP300
regulation of neuron death (GO:1901214)	-	4.19	0.0	BAX, NRAS, BRAF, PIK3CA, FGFR3, TP53, CTNNB1
negative regulation of neuron death (GO:1901215)	-	4.57	0.0	BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, BRAF, TLR4
epithelial tube formation (GO:0072175)	NEW	6.36	0.008	TP53, EP300, AKT1, CTNNB1
lipid homeostasis (GO:0055088)	NEW	5.0	0.001	BAX, CTNNB1, PLA2G2A, TP53, AKT1, EP300, CCND1
regulation of metal ion transport (GO:0010959)	-	3.94	0.012	BAX, AKT1, CCND1, PIK3CA, TP53, CTNNB1, KAT5, BRAF, TLR4
endocytosis (GO:0006897)	NEW	3.69	0.002	BAX, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
anterior/posterior pattern specification (GO:0009952)	-	4.71	0.006	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300
response to hydrogen peroxide (GO:0042542)	NEW	5.02	0.018	BAX, CTNNB1, CCND1, TP53, RAD54B, AKT1
regulation of epithelial to mesenchymal transition (GO:0010717)	-	5.55	0.001	CTNNB1, CCND1, TP53, AXIN2, AKT1, EP300
response to stimulus (GO:0050896)	-	1.22	0.0	PDGFRL, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, FGFR3, TLR4, ODC1, BRAF, MLH3
cognition (GO:0050890)	-	4.2	0.0	BAX, AKT1, NRAS, CCND1, TP53, ODC1, CTNNB1, KAT5, EP300, BRAF, TLR4
regulation of transferase activity (GO:0051338)	-	2.88	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
negative regulation of leukocyte activation (GO:0002695)	NEW	4.79	0.001	CCND1, DLC1, TP53, FGFR3, TLR4, CTNNB1, EP300, TLR2
regulation of leukocyte activation (GO:0002694)	-	3.6	0.0	BAX, CTNNB1, PTPN12, PLA2G2A, DLC1, TP53, FGFR3, PIK3CA, AKT1, TLR4, DCC, KAT5, EP300, CCND1, TLR2
positive regulation of nucleocytoplasmic transport (GO:0046824)	-	4.93	0.038	AURKA, TRIM28, TLR4, AKT1, KAT5, TLR2
positive regulation of leukocyte activation (GO:0002696)	-	4.0	0.0	AKT1, CCND1, DLC1, TP53, TLR4, PTPN12, PIK3CA, DCC, KAT5, EP300, TLR2
regulation of nucleocytoplasmic transport (GO:0046822)	-	4.33	0.0	AKT1, CCND1, AURKA, TP53, ODC1, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TRIM28, TLR2
negative regulation of nucleocytoplasmic transport (GO:0046823)	NEW	5.47	0.025	AXIN2, TP53, EP300, AKT1, CTNNB1
positive regulation of cell motility (GO:2000147)	-	3.74	0.0	APC, BAX, AKT1, PTPN12, CCND1, DLC1, TP53, BRAF, TLR4, RAD54B, TRIM28, CTNNB1, PIK3CA, EP300, PLA2G2A, TLR2
negative regulation of cell motility (GO:2000146)	-	4.36	0.014	AKT1, CCND1, DLC1, MCC, PTPRJ, TP53, CTNNB1, KAT5, EP300, BRAF, FLCN
regulation of protein maturation (GO:1903317)	NEW	5.33	0.001	APC, BAX, CTNNB1, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300
positive regulation of immune effector process (GO:0002699)	NEW	4.69	0.034	CCND1, TP53, TLR4, AKT1, KAT5, EP300, TLR2
negative regulation of cellular protein metabolic process (GO:0032269)	-	2.88	0.0	APC, BAX, AKT1, CCND1, BUB1B, PIK3CA, ODC1, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	-	3.96	0.009	BAX, NRAS, PIK3CA, FGFR3, TP53, AKT1, TLR4, DCC, EP300, TLR2
nucleoside metabolic process (GO:0009116)	NEW	4.12	0.001	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	NEW	6.2	0.01	CCND1, BAX, TP53, AKT1
transformed cell apoptotic process (GO:0006927)	NEW	7.94	0.004	BAX, TP53, AKT1
fatty acid metabolic process (GO:0006631)	NEW	4.03	0.025	BAX, CTNNB1, PLA2G2A, TP53, AKT1, KAT5, EP300, ODC1, TLR2
negative regulation of phosphorus metabolic process (GO:0010563)	-	3.45	0.048	APC, BAX, AKT1, NRAS, CCND1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
negative regulation of response to external stimulus (GO:0032102)	NEW	4.18	0.0	BAX, AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
positive regulation of response to external stimulus (GO:0032103)	-	4.17	0.0	AKT1, PLA2G2A, DLC1, TP53, RAD54B, TLR4, PTPN12, DCC, EP300, CCND1, TLR2
regulation of organelle organization (GO:0033043)	-	2.72	0.0	APC, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, ODC1, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, BRAF, FLCN
regulation of protein metabolic process (GO:0051246)	-	1.93	0.0	APC, BAX, TLR2, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, ODC1, EP300, BRAF, FLCN
positive regulation of MAP kinase activity (GO:0043406)	NEW	4.39	0.0	BAX, AKT1, PTPN12, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, TLR2
regulation of MAP kinase activity (GO:0043405)	-	3.95	0.0	BAX, CTNNB1, CCND1, AURKA, TP53, PTPRJ, TLR4, PTPN12, PIK3CA, AKT1, TLR2
morphogenesis of a branching epithelium (GO:0061138)	NEW	4.77	0.006	APC, AKT1, NRAS, CCND1, TP53, CTNNB1, DCC, EP300
cellular response to chemical stimulus (GO:0070887)	-	2.57	0.001	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
peptidyl-tyrosine dephosphorylation (GO:0035335)	-	5.1	0.001	AKT1, PTPN12, TP53, PTPRJ, CTNNB1, EP300, TLR4
mitochondrion organization (GO:0007005)	-	3.69	0.004	MT-CO1, CCND1, BAX, TP53, AKT1, KAT5, EP300, ODC1
heart looping (GO:0001947)	NEW	5.65	0.034	TP53, CCND1, EP300, AKT1, CTNNB1
ribonucleotide metabolic process (GO:0009259)	NEW	4.11	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TP53, RAD54B, TRIM28, TLR4, CTNNB1, PIK3CA, DCC, KAT5, EP300, BRAF, MLH3
negative regulation of MAPK cascade (GO:0043409)	-	4.74	0.0	APC, BRAF, TP53, PTPRJ, PIK3CA, AKT1, TLR4, CCND1, FLCN
regulation of MAPK cascade (GO:0043408)	-	3.22	0.0	APC, BAX, TLR2, AKT1, NRAS, PTPN12, CCND1, AURKA, TP53, BRAF, FGFR3, ODC1, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, AXIN2, KAT5, DLC1, FLCN
regulation of neurogenesis (GO:0050767)	-	3.21	0.0	APC, FGFR3, AKT1, PTPN12, CCND1, AURKA, TRIM28, BRAF, DLC1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, AXIN2, KAT5, EP300, ODC1, TLR2
negative regulation of protein metabolic process (GO:0051248)	-	2.82	0.0	APC, BAX, AKT1, CCND1, BUB1B, PIK3CA, BRAF, AXIN2, TP53, CTNNB1, DCC, PTPRJ, ODC1, EP300, KAT5, TLR4
regulation of lymphocyte activation (GO:0051249)	-	3.73	0.001	AKT1, PTPN12, CCND1, DLC1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
response to ionizing radiation (GO:0010212)	-	4.74	0.002	BAX, CCND1, TP53, TRIM28, AKT1, KAT5, EP300
cellular response to peptide hormone stimulus (GO:0071375)	-	4.63	0.011	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, EP300, TLR4
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of multicellular organismal process (GO:0051241)	-	2.84	0.0	TLR2, CTNNB1, CCND1, AURKA, TP53, AXIN2, PIK3CA, AKT1, TLR4, DCC, KAT5, EP300, ODC1, FLCN
regulation of cell cycle process (GO:0010564)	-	3.5	0.0	APC, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, PTPRJ, KAT5, EP300, ODC1, FLCN
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of neurogenesis (GO:0050768)	-	4.22	0.001	AKT1, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, EP300
positive regulation of neurogenesis (GO:0050769)	-	3.77	0.012	AKT1, CCND1, TP53, PTPRJ, PTPN12, CTNNB1, EP300, TLR2
regulation of cell morphogenesis involved in differentiation (GO:0010769)	-	3.91	0.0	CTNNB1, EP300, CCND1, BUB1B, TP53, AXIN2, PIK3CA, PTPN12, DCC, KAT5, AKT1, BRAF, DLC1
positive regulation of protein ubiquitination (GO:0031398)	NEW	4.55	0.0	CCND1, AURKA, TRIM28, FGFR3, TP53, AKT1, DCC, EP300
regulation of protein modification process (GO:0031399)	-	2.32	0.0	APC, BAX, AKT1, NRAS, DLC1, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, FLCN
regulation of protein ubiquitination (GO:0031396)	NEW	4.22	0.0	AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TRIM28, TP53, AKT1, DCC, EP300
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	-	5.76	0.005	BAX, KAT5, TP53, AKT1, TLR4
regulation of response to wounding (GO:1903034)	-	4.74	0.0	APC, BAX, PTPN12, CCND1, AURKA, TP53, PIK3CA, AKT1, TLR4, KAT5, EP300, PLA2G2A, TLR2
central nervous system neuron differentiation (GO:0021953)	NEW	5.17	0.004	BAX, CTNNB1, TP53, AXIN2, AKT1, DCC, EP300
central nervous system projection neuron axonogenesis (GO:0021952)	NEW	6.73	0.011	DCC, TP53, AKT1, CTNNB1
locomotion (GO:0040011)	-	2.91	0.0	APC, BAX, TLR2, PTPN12, NRAS, DLC1, EP300, CCND1, AURKA, TP53, FGFR3, RAD54B, PTPRJ, TRIM28, CTNNB1, TLR4, DCC, KAT5, AKT1, MLH3, PIK3CA
reproductive structure development (GO:0048608)	-	4.08	0.008	BAX, AKT1, CCND1, TRIM28, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, EP300
multicellular organismal reproductive process (GO:0048609)	-	3.35	0.0	BAX, AKT1, CCND1, AURKA, TRIM28, FGFR3, TLR4, TP53, TLR2, CTNNB1, PIK3CA, KAT5, EP300, ODC1, MLH3
cellular response to oxygen-containing compound (GO:1901701)	-	3.22	0.028	BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, ODC1, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	-	4.44	0.0	AKT1, CCND1, AURKA, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, TLR2
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TP53, RAD54B, TRIM28, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
cellular response to hydrogen peroxide (GO:0070301)	NEW	5.65	0.027	RAD54B, TP53, BAX, AKT1, CTNNB1
cellular response to lipid (GO:0071396)	-	3.96	0.0	TLR2, AKT1, PLA2G2A, AURKA, TP53, BRAF, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, CCND1, TLR4
negative regulation of cellular component movement (GO:0051271)	-	4.22	0.0	AKT1, CCND1, DLC1, MCC, PTPRJ, TP53, CTNNB1, KAT5, EP300, BRAF, FLCN
reactive oxygen species metabolic process (GO:0072593)	NEW	5.14	0.009	BAX, CTNNB1, PLA2G2A, TP53, AKT1, TLR4
negative regulation of cell activation (GO:0050866)	NEW	4.67	0.002	CCND1, DLC1, TP53, FGFR3, TLR4, CTNNB1, EP300, TLR2
positive regulation of ion transport (GO:0043270)	-	4.36	0.005	BAX, CTNNB1, CCND1, PLA2G2A, TP53, AKT1, BRAF, TLR2
regulation of locomotion (GO:0040012)	-	3.12	0.0	AKT1, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, PLA2G2A, MCC, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
viral process (GO:0016032)	-	3.15	0.001	BAX, AKT1, CCND1, DLC1, TRIM28, TP53, RAD54B, PTPRJ, PIK3CA, CTNNB1, KAT5, EP300, BRAF, TLR4
negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	NEW	7.43	0.026	AKT1, TP53, PIK3CA
organelle assembly (GO:0070925)	NEW	3.75	0.038	CTNNB1, AURKA, CCND1, BUB1B, TP53, AKT1, KAT5, EP300, DLC1
biological adhesion (GO:0022610)	-	2.81	0.001	APC, TLR2, CTNNB1, PTPN12, CCND1, AURKA, TP53, FGFR3, PIK3CA, AKT1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
long-term synaptic potentiation (GO:0060291)	NEW	6.07	0.044	BRAF, TP53, AKT1, TLR4
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.007	PIK3CA, AKT1, NRAS, CCND1, AURKA, TRIM28, TP53, RAD54B, TLR2, CTNNB1, TLR4, DCC, BRAF, MLH3
response to drug (GO:0042493)	-	3.71	0.0	BAX, AKT1, DLC1, CCND1, BUB1B, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, EP300, BRAF, TLR2
regulation of sarcomere organization (GO:0060297)	NEW	7.65	0.026	CCND1, EP300, AKT1
response to molecule of bacterial origin (GO:0002237)	-	3.99	0.001	BAX, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
positive regulation of response to wounding (GO:1903036)	-	5.76	0.046	PTPN12, PLA2G2A, TLR4, AKT1, CCND1, TLR2
protein localization to organelle (GO:0033365)	-	3.57	0.008	BUB1B, CCND1, AURKA, TP53, PTPRJ, AKT1, EP300
system development (GO:0048731)	-	2.92	0.0	APC, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, DCC, ODC1, KAT5, EP300, BRAF, TLR2
gland development (GO:0048732)	-	4.15	0.034	APC, AKT1, NRAS, CCND1, TP53, FGFR3, CTNNB1, EP300, BRAF
negative regulation of ERK1 and ERK2 cascade (GO:0070373)	-	5.74	0.002	BRAF, AKT1, TP53, FLCN, TLR4
regulation of ERK1 and ERK2 cascade (GO:0070372)	-	4.23	0.0	CCND1, TP53, FGFR3, PIK3CA, AKT1, TLR4, DCC, BRAF, FLCN
response to glucocorticoid (GO:0051384)	-	4.63	0.005	CTNNB1, CCND1, TP53, AKT1, DCC, EP300, BRAF, TLR4
single organismal cell-cell adhesion (GO:0016337)	-	3.69	0.0	PTPN12, EP300, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, DCC, KAT5, AKT1, TLR4
regulation of cell activation (GO:0050865)	-	3.53	0.0	BAX, AKT1, PLA2G2A, DLC1, TP53, FGFR3, TLR4, PTPN12, PIK3CA, DCC, KAT5, CTNNB1, EP300, CCND1, TLR2
regulation of B cell activation (GO:0050864)	NEW	4.92	0.032	CTNNB1, CCND1, TLR4, AKT1, EP300, TLR2
positive regulation of cell activation (GO:0050867)	-	3.97	0.001	PTPN12, CCND1, DLC1, PIK3CA, TP53, AKT1, TLR4, DCC, KAT5, EP300, TLR2
negative regulation of peptidyl-serine phosphorylation (GO:0033137)	NEW	6.59	0.002	CCND1, AKT1, BAX, CTNNB1
regulation of T cell activation (GO:0050863)	-	4.05	0.0	CTNNB1, PTPN12, CCND1, DLC1, PIK3CA, FGFR3, TP53, AKT1, KAT5, EP300, TLR4
striated muscle tissue development (GO:0014706)	NEW	5.23	0.034	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300
cell migration (GO:0016477)	-	3.12	0.0	APC, BAX, TLR2, AKT1, NRAS, PTPN12, AURKA, CCND1, DLC1, TP53, PIK3CA, TRIM28, CTNNB1, TLR4, DCC, KAT5, EP300, MLH3
positive regulation of muscle cell differentiation (GO:0051149)	-	5.26	0.019	DCC, CCND1, AKT1, TP53, CTNNB1
angiogenesis (GO:0001525)	NEW	4.15	0.003	BAX, AKT1, PTPN12, CCND1, PIK3CA, TP53, CTNNB1, KAT5, EP300, TLR4
intracellular signal transduction (GO:0035556)	-	2.39	0.005	BAX, NRAS, BRAF, DLC1, TP53, FGFR3, PIK3CA, AKT1, TLR4, KAT5, EP300, FLCN
activation of cysteine-type endopeptidase activity (GO:0097202)	NEW	7.24	0.003	BAX, CCND1, TP53, TLR4, AKT1, DLC1
regulation of protein transport (GO:0051223)	-	3.12	0.0	CTNNB1, DLC1, EP300, CCND1, AURKA, TP53, ODC1, AXIN2, TLR4, PTPN12, PIK3CA, KAT5, AKT1, TRIM28, TLR2
developmental maturation (GO:0021700)	-	4.7	0.002	CTNNB1, CCND1, PIK3CA, FGFR3, TP53, TRIM28, AKT1, KAT5, EP300
regulation of leukocyte differentiation (GO:1902105)	-	4.26	0.001	APC, CTNNB1, EP300, CCND1, TP53, TLR4, PTPN12, KAT5, AKT1, TLR2
spindle assembly (GO:0051225)	NEW	5.57	0.049	AURKA, EP300, TP53, AKT1
cellular response to estradiol stimulus (GO:0071392)	NEW	6.29	0.006	CCND1, EP300, KAT5, AKT1
regulation of endothelial cell proliferation (GO:0001936)	NEW	5.14	0.037	CTNNB1, CCND1, TP53, FGFR3, AKT1, EP300
regulation of angiogenesis (GO:0045765)	NEW	4.36	0.042	AKT1, PLA2G2A, TP53, PIK3CA, CTNNB1, KAT5, EP300, CCND1
lung epithelium development (GO:0060428)	NEW	7.33	0.039	FGFR3, CCND1, TP53
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	-	2.55	0.001	APC, BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, BRAF, FLCN
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of phosphate metabolic process (GO:0045936)	-	3.45	0.048	APC, BAX, AKT1, NRAS, CCND1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
regulation of endopeptidase activity (GO:0052548)	-	3.8	0.0	APC, BAX, TLR2, AKT1, DLC1, PLA2G2A, AURKA, TP53, TLR4, CTNNB1, KAT5, CCND1, FLCN
positive regulation of cell-substrate adhesion (GO:0010811)	-	5.11	0.022	CCND1, PTPRJ, AKT1, KAT5, BRAF, TLR4
response to ethanol (GO:0045471)	-	4.83	0.005	CTNNB1, CCND1, TP53, PIK3CA, AKT1, TLR4, TLR2
regulation of cartilage development (GO:0061035)	-	5.6	0.024	AXIN2, CCND1, EP300, AKT1, CTNNB1
cellular component disassembly (GO:0022411)	-	3.52	0.001	APC, BAX, PTPN12, EP300, CCND1, AURKA, TP53, CTNNB1, KAT5, AKT1, DLC1
genitalia morphogenesis (GO:0035112)	NEW	7.43	0.03	EP300, TP53, CTNNB1
synaptic transmission (GO:0007268)	NEW	3.98	0.001	MT-CO1, AKT1, CCND1, BUB1B, BAX, TP53, PIK3CA, CTNNB1, KAT5, EP300, BRAF, DLC1
response to estrogen (GO:0043627)	-	5.25	0.01	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300, TLR4
response to chemical (GO:0042221)	-	1.98	0.021	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, BRAF, TLR2
Ras protein signal transduction (GO:0007265)	-	4.76	0.001	CTNNB1, NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, BRAF
small GTPase mediated signal transduction (GO:0007264)	-	3.85	0.0	APC, AKT1, NRAS, AURKA, CCND1, DLC1, TP53, TRIM28, CTNNB1, PIK3CA, DCC, BRAF, TLR2
response to oxygen levels (GO:0070482)	-	4.02	0.0	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, TLR4, PTPN12, KAT5, AKT1, ODC1, TLR2
organelle organization (GO:0006996)	-	2.02	0.006	APC, BAX, AKT1, NRAS, AURKA, BUB1B, TP53, AXIN2, DLC1, CTNNB1, KAT5, EP300, MLH3
response to abiotic stimulus (GO:0009628)	-	2.8	0.0	APC, BAX, AKT1, NRAS, PTPN12, AURKA, CCND1, BUB1B, TP53, BRAF, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, DLC1, KAT5, EP300, ODC1, TLR2
positive regulation of leukocyte apoptotic process (GO:2000108)	-	6.33	0.019	CCND1, BAX, TP53, PIK3CA
regulation of peptide secretion (GO:0002791)	NEW	4.38	0.023	BAX, AKT1, CCND1, TP53, CTNNB1, ODC1, EP300, TLR4
regulation of leukocyte apoptotic process (GO:2000106)	-	5.33	0.007	BAX, CCND1, AURKA, PIK3CA, TP53, AKT1
response to glucose (GO:0009749)	-	4.86	0.007	BAX, AKT1, CCND1, TP53, CTNNB1, EP300, TLR4
DNA metabolic process (GO:0006259)	-	3.09	0.001	APC, BAX, AKT1, CCND1, AURKA, TRIM28, TP53, RAD54B, AXIN2, PIK3CA, CTNNB1, KAT5, EP300, MLH3
symbiosis, encompassing mutualism through parasitism (GO:0044403)	-	3.15	0.001	BAX, AKT1, DLC1, CCND1, TRIM28, TP53, RAD54B, PTPRJ, PIK3CA, CTNNB1, KAT5, EP300, BRAF, TLR4
mitotic cell cycle checkpoint (GO:0007093)	-	5.31	0.005	APC, CCND1, BUB1B, PIK3CA, TP53, AKT1
regulation of inflammatory response (GO:0050727)	-	4.03	0.0	APC, BAX, AKT1, PLA2G2A, TP53, TLR4, PTPN12, PIK3CA, KAT5, EP300, CCND1, TLR2
regulation of peptide transport (GO:0090087)	NEW	4.37	0.024	BAX, AKT1, CCND1, TP53, CTNNB1, ODC1, EP300, TLR4
positive regulation of apoptotic signaling pathway (GO:2001235)	-	4.58	0.013	BAX, CCND1, TP53, AKT1, KAT5, EP300, TLR4
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	NEW	5.13	0.037	BAX, CCND1, TP53, AXIN2, AKT1, KAT5
regulation of phosphate metabolic process (GO:0019220)	-	2.35	0.0	APC, BAX, AKT1, NRAS, CCND1, DLC1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, BRAF, FLCN
regulation of myotube differentiation (GO:0010830)	NEW	5.69	0.013	TP53, CCND1, EP300, AKT1, CTNNB1
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	-	5.05	0.001	CTNNB1, CCND1, AURKA, TP53, AKT1, EP300
anatomical structure homeostasis (GO:0060249)	-	4.25	0.001	APC, BAX, CTNNB1, CCND1, TP53, FGFR3, AKT1, KAT5, EP300, TLR4
protein dephosphorylation (GO:0006470)	-	4.47	0.0	AKT1, PTPN12, CCND1, AURKA, TP53, PTPRJ, CTNNB1, EP300, TLR4
negative regulation of response to stimulus (GO:0048585)	-	2.52	0.0	APC, BAX, AKT1, CCND1, DLC1, MCC, FGFR3, AXIN2, TP53, CTNNB1, TLR4, PTPRJ, FLCN
positive regulation of response to stimulus (GO:0048584)	-	2.18	0.0	BAX, TLR2, NRAS, BRAF, TRIM28, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, PLA2G2A, FLCN
cell development (GO:0048468)	-	3.28	0.005	BAX, AKT1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
regulation of homeostatic process (GO:0032844)	-	3.65	0.002	BAX, CTNNB1, EP300, PLA2G2A, TP53, TLR4, PTPN12, KAT5, AKT1, CCND1, FLCN
regulation of Wnt signaling pathway (GO:0030111)	-	3.98	0.0	APC, PIK3CA, AKT1, NRAS, CCND1, MCC, FGFR3, AXIN2, TP53, CTNNB1, TLR4, KAT5, EP300, ODC1, TLR2
regulation of histone modification (GO:0031056)	-	4.85	0.0	CTNNB1, CCND1, TP53, TLR4, AKT1, KAT5, EP300, FLCN
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.003	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
tissue homeostasis (GO:0001894)	-	4.78	0.0	BAX, CTNNB1, CCND1, TP53, FGFR3, AKT1, KAT5, EP300, TLR4
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.005	APC, BAX, AKT1, NRAS, DLC1, AURKA, PLA2G2A, BUB1B, TRIM28, FGFR3, TP53, AXIN2, FLCN, CTNNB1, DCC, KAT5, EP300, BRAF, MLH3
regulation of primary metabolic process (GO:0080090)	-	1.08	0.001	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of signal transduction (GO:0009968)	-	2.75	0.0	APC, BAX, TLR2, CTNNB1, NRAS, DLC1, EP300, CCND1, AURKA, TP53, FGFR3, PTPRJ, PIK3CA, AKT1, TLR4, DCC, AXIN2, KAT5, MCC, BRAF, FLCN
regulation of tumor necrosis factor biosynthetic process (GO:0042534)	NEW	6.84	0.007	TP53, AKT1, TLR2, TLR4
positive regulation of signal transduction (GO:0009967)	-	2.5	0.001	AKT1, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of metabolic process (GO:0009892)	-	1.93	0.0	APC, BAX, AKT1, CCND1, BUB1B, TP53, FGFR3, PTPRJ, TRIM28, CTNNB1, TLR4, KAT5, EP300, FLCN
kidney development (GO:0001822)	-	4.79	0.002	APC, BAX, CCND1, AURKA, TP53, AKT1, ODC1, EP300
regulation of chondrocyte differentiation (GO:0032330)	-	5.92	0.005	AXIN2, CCND1, EP300, AKT1, CTNNB1
organ development (GO:0048513)	-	2.53	0.017	APC, BAX, AKT1, CCND1, TP53, PTPRJ, CTNNB1, ODC1, EP300, FLCN
placenta development (GO:0001890)	NEW	5.99	0.049	CCND1, EP300, TP53, AKT1
positive regulation of cell development (GO:0010720)	-	3.57	0.0	CTNNB1, EP300, CCND1, AURKA, TP53, AXIN2, PTPN12, PTPRJ, AKT1, BRAF, TLR2
negative regulation of cell development (GO:0010721)	-	4.02	0.001	AKT1, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, KAT5, EP300
positive regulation of biological process (GO:0048518)	-	1.2	0.0	TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
negative regulation of biological process (GO:0048519)	-	1.33	0.0	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, CCND1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	-	4.27	0.0	CTNNB1, DLC1, TP53, AURKA, TRIM28, PIK3CA, AKT1, TLR4, KAT5, EP300, ODC1, TLR2
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	-	4.54	0.0	AKT1, DLC1, CCND1, AURKA, TP53, TLR4, CTNNB1, EP300, TLR2
regulation of cell proliferation (GO:0042127)	-	2.41	0.0	APC, BAX, TLR2, AKT1, NRAS, DLC1, CCND1, PLA2G2A, TP53, FGFR3, AXIN2, MCC, CTNNB1, TLR4, PTPRJ, ODC1, BRAF, FLCN
neurotrophin signaling pathway (GO:0038179)	NEW	6.55	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, ODC1, EP300, BRAF, TLR4
regulation of cell junction assembly (GO:1901888)	-	5.49	0.005	TP53, CCND1, PTPRJ, DLC1, AKT1
sensory perception of sound (GO:0007605)	NEW	4.82	0.032	BAX, AKT1, TP53, TRIM28, CTNNB1, KAT5, EP300
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.0	BAX, PIK3CA, AKT1, NRAS, AURKA, CCND1, DLC1, TRIM28, TP53, RAD54B, TLR2, CTNNB1, TLR4, DCC, EP300, BRAF, MLH3
visual perception (GO:0007601)	NEW	4.41	0.001	AKT1, CCND1, AURKA, TP53, PTPRJ, CTNNB1, DCC, KAT5, EP300, BRAF
sensory perception (GO:0007600)	NEW	2.93	0.018	BAX, AKT1, CCND1, AURKA, TP53, PTPRJ, TRIM28, CTNNB1, DCC, KAT5, EP300, BRAF
alpha-beta T cell differentiation (GO:0046632)	NEW	6.15	0.006	TP53, EP300, AKT1, CTNNB1, BRAF
heart morphogenesis (GO:0003007)	NEW	5.84	0.005	DLC1, TP53, EP300, AKT1, CTNNB1
developmental process involved in reproduction (GO:0003006)	-	3.36	0.001	BAX, AKT1, CCND1, AURKA, PIK3CA, FGFR3, TP53, AXIN2, TRIM28, CTNNB1, TLR4, PTPRJ, KAT5, EP300, MLH3
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	-	3.83	0.0	TLR2, CTNNB1, EP300, CCND1, TP53, BRAF, AXIN2, PIK3CA, PTPN12, KAT5, AKT1, PLA2G2A, TLR4
epidermal growth factor receptor signaling pathway (GO:0007173)	-	5.72	0.0	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, ODC1, EP300, TLR4
regionalization (GO:0003002)	-	4.24	0.038	APC, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, KAT5, EP300
regulation of skeletal muscle tissue development (GO:0048641)	NEW	5.78	0.032	AKT1, TP53, EP300, NRAS, CTNNB1
response to peptide hormone (GO:0043434)	-	4.06	0.049	APC, AKT1, NRAS, CCND1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, BRAF, TLR2
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	NEW	4.82	0.0	CTNNB1, PLA2G2A, TP53, AXIN2, TLR2, AKT1, EP300, CCND1, TLR4
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.003	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
single organism signaling (GO:0044700)	-	3.25	0.0	MT-CO1, AKT1, DLC1, CCND1, BUB1B, BAX, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, KAT5, EP300, ODC1, TLR4
multi-organism reproductive process (GO:0044703)	NEW	4.82	0.008	CTNNB1, CCND1, PIK3CA, TP53, AKT1, KAT5, EP300, TLR4
cellular response to abiotic stimulus (GO:0071214)	-	4.15	0.0	BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
protein modification by small protein conjugation (GO:0032446)	-	3.1	0.001	BAX, AKT1, CCND1, AURKA, TP53, RAD54B, TRIM28, CTNNB1, KAT5, EP300, BRAF, TLR4
single-multicellular organism process (GO:0044707)	-	1.78	0.01	APC, BAX, AKT1, NRAS, PLA2G2A, AURKA, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, PTPRJ, EP300, CCND1, TLR4
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	-	4.62	0.037	CCND1, PIK3CA, FGFR3, TP53, AKT1, KAT5, TLR4
single-organism behavior (GO:0044708)	-	3.79	0.002	BAX, AKT1, NRAS, CCND1, BUB1B, TP53, ODC1, CTNNB1, KAT5, EP300, BRAF, TLR4
response to organonitrogen compound (GO:0010243)	-	3.2	0.002	APC, BAX, AKT1, NRAS, DLC1, CCND1, BUB1B, TP53, FGFR3, ODC1, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Wnt signaling pathway (GO:0016055)	-	3.88	0.007	APC, CTNNB1, CCND1, MCC, AXIN2, TP53, AKT1, EP300, TLR4
response to interleukin-1 (GO:0070555)	NEW	5.07	0.007	CCND1, BUB1B, PIK3CA, TP53, AKT1, TLR2
immune system process (GO:0002376)	-	2.29	0.006	APC, BAX, AKT1, NRAS, BRAF, TP53, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, EP300, TLR2
circulatory system process (GO:0003013)	-	4.38	0.018	BAX, AKT1, CCND1, TP53, PTPRJ, CTNNB1, TLR4
cellular response to stress (GO:0033554)	-	2.51	0.031	APC, BAX, CCND1, TP53, RAD54B, TRIM28, AKT1, KAT5, EP300, MLH3
regulation of microtubule cytoskeleton organization (GO:0070507)	-	4.98	0.011	APC, CTNNB1, AURKA, TP53, AKT1, KAT5
regulation of canonical Wnt signaling pathway (GO:0060828)	-	4.26	0.0	APC, AKT1, CCND1, MCC, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, KAT5, EP300, TLR4
signal transduction (GO:0007165)	-	1.28	0.001	APC, BAX, TLR2, CTNNB1, NRAS, PDGFRL, DLC1, TP53, BRAF, FGFR3, PIK3CA, AXIN2, MCC, AKT1, TLR4, DCC, PTPRJ, KAT5, EP300, CCND1, FLCN
regulation of cell morphogenesis (GO:0022604)	-	3.4	0.0	APC, AKT1, PTPN12, CCND1, BUB1B, PIK3CA, ODC1, AXIN2, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, DLC1
cellular component disassembly involved in execution phase of apoptosis (GO:0006921)	NEW	6.47	0.003	APC, KAT5, AKT1, CTNNB1, PTPN12
positive regulation of kinase activity (GO:0033674)	-	3.54	0.02	APC, BAX, CTNNB1, NRAS, EP300, CCND1, AURKA, TP53, FGFR3, ODC1, TLR4, PTPN12, PIK3CA, KAT5, AKT1, BRAF, TLR2
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.0	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
cellular response to mechanical stimulus (GO:0071260)	-	5.33	0.0	AKT1, PIK3CA, TP53, CTNNB1, KAT5, EP300, TLR4
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.002	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
regulation of DNA binding (GO:0051101)	-	5.21	0.003	APC, CTNNB1, TP53, AKT1, KAT5, EP300
negative regulation of binding (GO:0051100)	-	4.85	0.0	BAX, AKT1, CCND1, AURKA, TP53, PTPRJ, CTNNB1, EP300
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.002	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
single organism cell adhesion (GO:0098602)	-	3.63	0.0	AKT1, PTPN12, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, KAT5, EP300, TLR4
positive regulation of DNA binding (GO:0043388)	NEW	6.02	0.031	EP300, TP53, AKT1, TLR4
regulation of apoptotic process (GO:0042981)	-	2.5	0.0	APC, BAX, AKT1, NRAS, AURKA, BRAF, DLC1, TP53, FGFR3, PIK3CA, CTNNB1, DCC, FLCN
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	-	7.09	0.0	TP53, AKT1, TLR2, TLR4
response to cytokine (GO:0034097)	-	3.84	0.0	BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
endothelial cell migration (GO:0043542)	NEW	5.69	0.017	CCND1, EP300, TP53, PIK3CA, BAX
positive regulation of GTPase activity (GO:0043547)	-	3.28	0.003	APC, AKT1, CCND1, DLC1, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, BRAF, FLCN
regulation of gliogenesis (GO:0014013)	NEW	5.21	0.0	CTNNB1, CCND1, FGFR3, AKT1, ODC1, EP300, TLR2
regulation of kinase activity (GO:0043549)	-	3.07	0.0	APC, BAX, PIK3CA, CTNNB1, NRAS, EP300, CCND1, AURKA, TP53, BRAF, FGFR3, PTPRJ, TRIM28, PTPN12, TLR4, DCC, ODC1, AKT1, KAT5, TLR2
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, BRAF, TLR2
cellular response to molecule of bacterial origin (GO:0071219)	-	4.88	0.0	CCND1, AURKA, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
positive regulation of intracellular transport (GO:0032388)	-	4.08	0.0	BAX, CCND1, AURKA, TP53, TRIM28, TLR4, AKT1, KAT5, ODC1, TLR2
cellular response to biotic stimulus (GO:0071216)	-	4.76	0.0	CCND1, AURKA, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
positive regulation of translation (GO:0045727)	NEW	5.14	0.025	CCND1, EP300, TP53, AKT1, TLR4
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	DLC1, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, TRIM28, TLR2
regulation of lymphocyte differentiation (GO:0045619)	NEW	4.84	0.0	CTNNB1, NRAS, EP300, CCND1, TP53, PTPN12, KAT5, AKT1, TLR2
tube closure (GO:0060606)	NEW	5.36	0.007	CCND1, TP53, TLR4, AKT1, EP300, DLC1
sensory perception of mechanical stimulus (GO:0050954)	NEW	4.79	0.043	BAX, AKT1, TP53, TRIM28, CTNNB1, KAT5, EP300
sensory perception of light stimulus (GO:0050953)	NEW	4.4	0.001	AKT1, CCND1, AURKA, TP53, PTPRJ, CTNNB1, DCC, KAT5, EP300, BRAF
heterocycle catabolic process (GO:0046700)	NEW	3.82	0.0	BAX, PIK3CA, AKT1, NRAS, AURKA, CCND1, DLC1, TRIM28, TP53, RAD54B, TLR2, CTNNB1, TLR4, DCC, EP300, BRAF, MLH3
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	-	3.82	0.0	BAX, CTNNB1, CCND1, TRIM28, TP53, TLR4, AKT1, EP300, TLR2
cell activation (GO:0001775)	-	3.47	0.0	APC, BAX, AKT1, CCND1, DLC1, TRIM28, ODC1, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
negative regulation of multi-organism process (GO:0043901)	NEW	4.7	0.003	CCND1, TP53, TRIM28, AKT1, TLR4, EP300, TLR2
inflammatory response (GO:0006954)	-	3.64	0.0	APC, PTPN12, DLC1, CCND1, AURKA, TP53, FGFR3, RAD54B, PIK3CA, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
negative regulation of intracellular signal transduction (GO:1902532)	-	3.63	0.028	APC, BAX, AKT1, DLC1, CCND1, AURKA, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, BRAF, FLCN
regulation of protein import into nucleus (GO:0042306)	-	4.54	0.0	AKT1, CCND1, AURKA, TP53, ODC1, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, TRIM28, TLR2
regulation of ossification (GO:0030278)	-	4.53	0.014	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300
regulation of intracellular signal transduction (GO:1902531)	-	2.31	0.0	APC, BAX, AKT1, NRAS, BRAF, DLC1, TP53, FGFR3, PTPRJ, TLR2, CTNNB1, TLR4, DCC, FLCN
regulation of protein localization to nucleus (GO:1900180)	-	4.34	0.011	AKT1, CCND1, AURKA, TP53, TLR4, AXIN2, FLCN, CTNNB1, PIK3CA, ODC1, KAT5, TRIM28, TLR2
secretion (GO:0046903)	-	3.38	0.037	BAX, AKT1, DLC1, PLA2G2A, BUB1B, TP53, PIK3CA, CTNNB1, KAT5, EP300, CCND1, TLR4
regulation of protein processing (GO:0070613)	NEW	5.35	0.001	APC, BAX, CTNNB1, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300
cellular nitrogen compound catabolic process (GO:0044270)	NEW	3.8	0.0	BAX, TLR2, AKT1, NRAS, DLC1, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, EP300, BRAF, MLH3
protein maturation (GO:0051604)	NEW	4.48	0.0	BAX, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
programmed cell death (GO:0012501)	-	3.1	0.0	APC, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, PTPRJ, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, DLC1, TLR2
response to decreased oxygen levels (GO:0036293)	-	4.09	0.0	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, PTPN12, KAT5, AKT1, ODC1, TLR2
negative regulation of protein modification process (GO:0031400)	-	3.4	0.0	APC, BAX, AKT1, CCND1, BUB1B, PIK3CA, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
positive regulation of protein modification process (GO:0031401)	-	2.7	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of multi-organism process (GO:0043900)	-	3.6	0.008	BAX, CTNNB1, CCND1, AURKA, TRIM28, TP53, TLR4, AKT1, EP300, TLR2
cellular response to decreased oxygen levels (GO:0036294)	-	5.05	0.001	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300
coagulation (GO:0050817)	NEW	4.51	0.0	APC, AKT1, NRAS, CCND1, AURKA, PIK3CA, ODC1, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
DNA-templated transcription, initiation (GO:0006352)	NEW	4.49	0.006	AKT1, CCND1, TP53, TRIM28, CTNNB1, DCC, KAT5, EP300
posttranscriptional regulation of gene expression (GO:0010608)	-	3.64	0.017	AKT1, CCND1, AURKA, PIK3CA, AXIN2, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
endocrine pancreas development (GO:0031018)	NEW	6.36	0.002	CCND1, EP300, TP53, AKT1, BAX
regulation of cell adhesion (GO:0030155)	-	3.27	0.0	APC, AKT1, PTPN12, AURKA, CCND1, DLC1, TP53, BRAF, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, PLA2G2A, FLCN
cellular component assembly involved in morphogenesis (GO:0010927)	NEW	4.29	0.028	CTNNB1, BUB1B, AURKA, TP53, AKT1, ODC1, EP300, TLR2
negative regulation of Rho protein signal transduction (GO:0035024)	-	7.09	0.026	FLCN, DLC1, AKT1
positive regulation of protein import into nucleus (GO:0042307)	-	5.11	0.012	AURKA, TRIM28, TLR4, AKT1, KAT5, TLR2
positive regulation of nitric oxide biosynthetic process (GO:0045429)	-	5.99	0.04	AKT1, TLR2, TLR4
retina development in camera-type eye (GO:0060041)	NEW	5.51	0.002	APC, BAX, TP53, AKT1, KAT5, EP300
epithelial cell morphogenesis (GO:0003382)	NEW	6.04	0.006	TP53, CCND1, EP300, AKT1, CTNNB1
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.0	BAX, PIK3CA, PTPN12, NRAS, DLC1, EP300, CCND1, AURKA, TP53, FGFR3, RAD54B, AXIN2, TLR2, CTNNB1, TLR4, DCC, PTPRJ, KAT5, AKT1, BRAF, FLCN
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	-	5.26	0.006	BAX, CCND1, PIK3CA, AKT1, BRAF, FLCN
response to mechanical stimulus (GO:0009612)	-	4.41	0.014	CTNNB1, CCND1, PIK3CA, TP53, AKT1, KAT5, EP300, TLR4
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.014	NRAS, BRAF, PIK3CA, FGFR3, TP53, AKT1, ODC1, TLR4
protein autophosphorylation (GO:0046777)	-	4.46	0.0	AKT1, PTPN12, CCND1, AURKA, TRIM28, FGFR3, TP53, CTNNB1, DLC1
response to endogenous stimulus (GO:0009719)	-	2.79	0.001	AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, DCC, KAT5, EP300, BRAF, TLR2
I-kappaB phosphorylation (GO:0007252)	-	7.24	0.026	AKT1, TLR2, TLR4
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.001	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)	-	5.6	0.001	APC, CCND1, EP300, TP53, AKT1
regulation of protein modification by small protein conjugation or removal (GO:1903320)	-	4.14	0.0	AKT1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, TRIM28, CTNNB1, DCC, EP300
negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	-	4.8	0.048	BUB1B, TP53, EP300, PIK3CA, CTNNB1
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	NEW	4.48	0.0	AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TRIM28, TP53, AKT1, DCC, EP300
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
regulation of peptidyl-serine phosphorylation (GO:0033135)	-	4.98	0.0	BAX, CTNNB1, CCND1, PIK3CA, TLR4, AKT1, BRAF, FLCN
proteolysis (GO:0006508)	-	2.73	0.007	APC, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, KAT5, EP300, BRAF, TLR4
apoptotic process involved in morphogenesis (GO:0060561)	NEW	6.96	0.0	BAX, AKT1, CCND1, TP53, CTNNB1, EP300
developmental growth involved in morphogenesis (GO:0060560)	NEW	5.15	0.016	CTNNB1, AURKA, TP53, FGFR3, AKT1, TLR4
negative regulation of neural precursor cell proliferation (GO:2000178)	NEW	6.64	0.006	CCND1, EP300, TP53, AKT1
regulation of exocytosis (GO:0017157)	NEW	4.59	0.0	AKT1, CCND1, PIK3CA, TP53, CTNNB1, DCC, KAT5, BRAF
cellular response to endogenous stimulus (GO:0071495)	-	3.33	0.014	BAX, AKT1, NRAS, CCND1, TRIM28, TP53, FGFR3, ODC1, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
cellular response to external stimulus (GO:0071496)	-	4.2	0.004	BAX, AKT1, CCND1, PIK3CA, TP53, CTNNB1, KAT5, EP300, TLR4
regulation of JAK-STAT cascade (GO:0046425)	NEW	4.78	0.004	CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	-	6.2	0.016	TP53, CCND1, AKT1, TLR2, TLR4
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	-	4.32	0.001	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, DCC
regulation of actin filament-based process (GO:0032970)	-	3.97	0.003	CTNNB1, CCND1, AURKA, TP53, DLC1, AKT1, DCC, EP300, BRAF, TLR4
positive regulation of protein complex assembly (GO:0031334)	-	4.44	0.001	APC, BAX, CTNNB1, AURKA, TP53, AKT1, EP300, TLR4
regulation of endothelial cell apoptotic process (GO:2000351)	NEW	5.99	0.002	CCND1, KAT5, TP53, AKT1, BRAF
regulation of vesicle-mediated transport (GO:0060627)	NEW	3.63	0.0	APC, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
regulation of stress-activated MAPK cascade (GO:0032872)	-	4.45	0.0	AKT1, CCND1, AURKA, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, TLR2
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	-	4.43	0.001	BAX, CTNNB1, DLC1, CCND1, AURKA, TP53, TLR4, AKT1, FLCN
cellular response to hormone stimulus (GO:0032870)	-	3.99	0.006	AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, TRIM28, CTNNB1, DCC, KAT5, EP300, TLR4
immune response-activating signal transduction (GO:0002757)	-	3.8	0.008	BAX, AKT1, CCND1, DLC1, TP53, TLR4, PTPN12, PIK3CA, DCC, TLR2
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	-	4.96	0.019	BAX, CCND1, TP53, TLR4, AKT1, DLC1
protein processing (GO:0016485)	NEW	4.62	0.0	BAX, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
regulation of localization (GO:0032879)	-	1.94	0.001	APC, BAX, TLR2, AKT1, BRAF, DLC1, MCC, TP53, AXIN2, TRIM28, CTNNB1, TLR4, PTPRJ, FLCN
defense response to virus (GO:0051607)	NEW	4.63	0.007	BAX, CCND1, PIK3CA, TP53, AKT1, EP300, TLR4
protein oligomerization (GO:0051259)	-	3.71	0.008	BAX, AKT1, BRAF, PIK3CA, TP53, RAD54B, TRIM28, CTNNB1, KAT5, EP300, DLC1
regulation of immune response (GO:0050776)	-	2.98	0.0	APC, BAX, AKT1, NRAS, PLA2G2A, DLC1, TP53, FGFR3, PTPRJ, TLR4, PTPN12, PIK3CA, DCC, KAT5, CTNNB1, EP300, CCND1, TLR2
regulation of epithelial cell proliferation (GO:0050678)	-	4.06	0.0	APC, BAX, AKT1, PLA2G2A, AURKA, TP53, FGFR3, RAD54B, AXIN2, MCC, CTNNB1, EP300, CCND1, TLR2
positive regulation of epithelial cell proliferation (GO:0050679)	-	4.67	0.0	AKT1, CCND1, AURKA, TP53, FGFR3, RAD54B, AXIN2, CTNNB1, EP300, TLR2
regulation of dendrite development (GO:0050773)	NEW	4.93	0.004	PTPN12, CCND1, PIK3CA, TP53, AKT1, DCC, EP300
positive regulation of lymphocyte activation (GO:0051251)	-	4.07	0.002	PTPN12, CCND1, DLC1, PIK3CA, TP53, AKT1, TLR4, KAT5, EP300, TLR2
negative regulation of lymphocyte activation (GO:0051250)	NEW	4.95	0.0	CCND1, DLC1, TP53, FGFR3, TLR4, CTNNB1, EP300, TLR2
response to fatty acid (GO:0070542)	NEW	5.88	0.012	CCND1, KAT5, AKT1, TLR2, BAX
regulation of lymphocyte proliferation (GO:0050670)	-	4.46	0.001	AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
positive regulation of immune response (GO:0050778)	-	3.4	0.005	APC, BAX, AKT1, CCND1, DLC1, TP53, TLR4, PTPN12, PIK3CA, DCC, EP300, TLR2
epithelial cell proliferation (GO:0050673)	-	5.21	0.001	BAX, CCND1, TP53, FGFR3, AKT1, EP300, TLR4
negative regulation of intracellular transport (GO:0032387)	NEW	5.02	0.021	CTNNB1, TP53, AXIN2, AKT1, EP300, TLR4
regulation of cytokine production (GO:0001817)	-	3.4	0.02	CTNNB1, EP300, CCND1, DLC1, TP53, RAD54B, TLR4, PTPN12, PIK3CA, KAT5, AKT1, TLR2
regulation of type I interferon production (GO:0032479)	-	5.03	0.01	CTNNB1, CCND1, TLR4, AKT1, EP300, TLR2
negative regulation of cell morphogenesis involved in differentiation (GO:0010771)	-	4.96	0.0	AKT1, CCND1, TP53, CTNNB1, KAT5, EP300
positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	-	4.65	0.029	AXIN2, BRAF, EP300, AKT1, CTNNB1
regulation of response to stress (GO:0080134)	-	2.53	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
response to steroid hormone (GO:0048545)	-	4.24	0.0	BAX, AKT1, CCND1, TRIM28, ODC1, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
positive regulation of cytokine production (GO:0001819)	-	3.82	0.0	CTNNB1, EP300, CCND1, TP53, RAD54B, TLR4, PTPN12, PIK3CA, KAT5, AKT1, TLR2
regulation of chromatin organization (GO:1902275)	-	4.69	0.0	CTNNB1, CCND1, AURKA, TP53, TLR4, AKT1, KAT5, EP300, FLCN
cellular homeostasis (GO:0019725)	-	3.23	0.0	APC, BAX, AKT1, DLC1, CCND1, AURKA, TP53, TLR4, TLR2, CTNNB1, PIK3CA, KAT5, EP300, BRAF, MLH3
regulation of cellular response to stress (GO:0080135)	-	3.4	0.0	APC, BAX, PIK3CA, PTPN12, EP300, AURKA, CCND1, BUB1B, TP53, AXIN2, TRIM28, CTNNB1, TLR4, KAT5, AKT1, TLR2
cellular response to lipopolysaccharide (GO:0071222)	NEW	4.94	0.0	CCND1, AURKA, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
toll-like receptor 3 signaling pathway (GO:0034138)	NEW	7.65	0.01	CCND1, TLR2, TP53, AKT1, TLR4
regulation of striated muscle tissue development (GO:0016202)	NEW	5.09	0.013	CTNNB1, NRAS, CCND1, TP53, AKT1, KAT5, EP300
toll-like receptor 2 signaling pathway (GO:0034134)	NEW	7.94	0.009	TP53, CCND1, AKT1, TLR2, TLR4
cellular response to steroid hormone stimulus (GO:0071383)	NEW	5.51	0.05	CCND1, TP53, TRIM28, AKT1, KAT5, EP300
B cell activation (GO:0042113)	-	4.84	0.001	BAX, AKT1, CCND1, TRIM28, TP53, CTNNB1, EP300, TLR4
branching morphogenesis of an epithelial tube (GO:0048754)	NEW	4.93	0.002	APC, AKT1, NRAS, CCND1, TP53, CTNNB1, DCC, EP300
cellular response to acid chemical (GO:0071229)	NEW	4.67	0.007	CTNNB1, CCND1, BUB1B, TP53, AKT1, KAT5, BRAF, DLC1
cellular response to insulin stimulus (GO:0032869)	NEW	5.29	0.01	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, EP300
regulation of JUN kinase activity (GO:0043506)	NEW	5.33	0.007	CTNNB1, CCND1, AURKA, PIK3CA, AKT1, TLR2
GTP metabolic process (GO:0046039)	NEW	6.59	0.043	NRAS, CCND1, AURKA, PIK3CA, TRIM28, AKT1, DCC, BRAF
cerebral cortex development (GO:0021987)	NEW	5.57	0.0	BAX, CTNNB1, CCND1, AURKA, AKT1, EP300
regulation of ion transport (GO:0043269)	-	3.4	0.0	BAX, CTNNB1, DLC1, PLA2G2A, BUB1B, TP53, BRAF, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.0	APC, BAX, AKT1, CCND1, TP53, AXIN2, TRIM28, CTNNB1, PIK3CA, PTPRJ, KAT5, EP300, TLR4
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.001	BAX, AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
defense response to Gram-positive bacterium (GO:0050830)	-	5.54	0.001	PLA2G2A, TP53, TLR2, AKT1, TLR4, DLC1
positive regulation of transport (GO:0051050)	-	2.9	0.0	APC, BAX, PTPN12, DLC1, TLR4, PLA2G2A, AURKA, TP53, BRAF, FGFR3, ODC1, AXIN2, TRIM28, AKT1, PIK3CA, DCC, KAT5, EP300, CCND1, TLR2
zymogen activation (GO:0031638)	NEW	6.33	0.001	BAX, CCND1, DLC1, TP53, TLR4, AKT1, TLR2
cellular component morphogenesis (GO:0032989)	-	3.5	0.0	APC, BAX, CTNNB1, EP300, CCND1, AURKA, TP53, FGFR3, TRIM28, PTPN12, PIK3CA, DCC, ODC1, AKT1, KAT5, TLR4
regulation of response to external stimulus (GO:0032101)	-	3.06	0.0	APC, BAX, AKT1, PTPN12, AURKA, PLA2G2A, BUB1B, TP53, BRAF, DLC1, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, CCND1, TLR2
regulation of interleukin-8 production (GO:0032677)	-	5.62	0.002	PIK3CA, RAD54B, TP53, AKT1, TLR4, TLR2
cellular response to organic substance (GO:0071310)	-	2.78	0.002	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, BRAF, TLR2
regulation of transcription from RNA polymerase II promoter (GO:0006357)	-	2.24	0.03	AKT1, CCND1, TRIM28, TP53, FGFR3, TLR2, CTNNB1, TLR4, KAT5, EP300, FLCN
tissue morphogenesis (GO:0048729)	-	3.87	0.001	APC, CTNNB1, NRAS, EP300, CCND1, TRIM28, FGFR3, TP53, PTPN12, DCC, KAT5, AKT1
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.001	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
negative regulation of cell migration (GO:0030336)	-	4.41	0.012	AKT1, CCND1, DLC1, MCC, PTPRJ, TP53, CTNNB1, KAT5, EP300, BRAF, FLCN
positive regulation of cell migration (GO:0030335)	-	3.77	0.0	APC, BAX, CTNNB1, PTPN12, PLA2G2A, DLC1, TP53, BRAF, TLR4, RAD54B, TRIM28, AKT1, PIK3CA, EP300, CCND1, TLR2
regulation of cell migration (GO:0030334)	-	3.23	0.0	AKT1, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, PLA2G2A, MCC, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
positive regulation of JAK-STAT cascade (GO:0046427)	NEW	5.44	0.01	FGFR3, CCND1, AKT1, TP53, PIK3CA
response to nutrient (GO:0007584)	NEW	4.49	0.012	BAX, CCND1, TP53, TLR4, AKT1, KAT5, EP300, TLR2
respiratory gaseous exchange (GO:0007585)	NEW	5.86	0.029	TP53, EP300, AKT1, CTNNB1, TLR4
negative regulation of RNA biosynthetic process (GO:1902679)	-	2.7	0.002	APC, BAX, AKT1, AURKA, CCND1, DLC1, TP53, FGFR3, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, BRAF, FLCN
nucleotide metabolic process (GO:0009117)	NEW	3.73	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, MLH3
negative regulation of Ras protein signal transduction (GO:0046580)	-	6.07	0.0	TP53, FLCN, AKT1, PIK3CA, DCC, DLC1
regulation of cytokine production involved in immune response (GO:0002718)	NEW	5.69	0.015	TP53, CCND1, AKT1, TLR2, TLR4
cellular response to oxidative stress (GO:0034599)	NEW	4.7	0.001	BAX, CTNNB1, PTPN12, TP53, RAD54B, AKT1, EP300, TLR4
regulation of nucleoside metabolic process (GO:0009118)	NEW	5.82	0.0	APC, AKT1, DLC1, CCND1, AURKA, TP53, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, PTPRJ, KAT5, BRAF, FLCN
macromolecule catabolic process (GO:0009057)	-	3.0	0.001	BAX, AKT1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
cellular localization (GO:0051641)	-	2.32	0.016	AKT1, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, PTPRJ, EP300, TLR4
DNA recombination (GO:0006310)	-	4.39	0.023	AKT1, CCND1, TP53, RAD54B, CTNNB1, EP300, MLH3
DNA damage checkpoint (GO:0000077)	-	5.37	0.044	AKT1, CCND1, EP300, TP53, PIK3CA
cell cycle checkpoint (GO:0000075)	-	4.79	0.009	APC, BUB1B, CCND1, AURKA, PIK3CA, TP53, AKT1
regulation of cell cycle (GO:0051726)	-	2.93	0.0	APC, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, KAT5, EP300, ODC1, FLCN
response to alcohol (GO:0097305)	-	4.58	0.001	BAX, AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, TLR2
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	-	5.26	0.0	APC, CCND1, AURKA, TP53, FGFR3, AKT1, EP300
glycosyl compound metabolic process (GO:1901657)	NEW	4.04	0.002	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
single-organism organelle organization (GO:1902589)	-	2.68	0.001	APC, BAX, NRAS, AURKA, BUB1B, TP53, AXIN2, DLC1, CTNNB1, KAT5, EP300, MLH3
response to peptide (GO:1901652)	-	3.94	0.0	APC, AKT1, NRAS, CCND1, TP53, FGFR3, ODC1, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
cellular response to peptide (GO:1901653)	-	4.52	0.0	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4, DCC, KAT5, EP300, TLR2
response to carbohydrate (GO:0009743)	-	4.62	0.003	BAX, CTNNB1, CCND1, TP53, TLR4, AKT1, EP300, TLR2
regulation of growth (GO:0040008)	-	3.26	0.0	PLA2G2A, BAX, TLR2, CTNNB1, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, DCC, PTPRJ, KAT5, EP300, TRIM28, FLCN
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.005	AKT1, NRAS, AURKA, CCND1, TRIM28, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
positive regulation of neuron projection development (GO:0010976)	-	4.26	0.024	CCND1, PIK3CA, TP53, AKT1, DCC, BRAF
regulation of histone acetylation (GO:0035065)	-	5.74	0.0	CCND1, TP53, TLR4, AKT1, EP300, FLCN
negative regulation of epithelial cell proliferation (GO:0050680)	NEW	4.98	0.0	APC, CTNNB1, PLA2G2A, MCC, FGFR3, TP53, AKT1, EP300, CCND1
alpha-beta T cell activation (GO:0046631)	NEW	5.92	0.014	TP53, EP300, AKT1, CTNNB1, BRAF
male gonad development (GO:0008584)	NEW	5.08	0.016	AKT1, CCND1, PIK3CA, TP53, CTNNB1, EP300
protein phosphorylation (GO:0006468)	-	2.89	0.001	DLC1, TLR2, AKT1, PTPN12, AURKA, CCND1, BUB1B, TRIM28, FGFR3, ODC1, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
positive regulation of chemotaxis (GO:0050921)	NEW	4.94	0.05	CCND1, TP53, TLR2, AKT1, TLR4, DLC1
neuron differentiation (GO:0030182)	NEW	4.17	0.0	BAX, AKT1, CCND1, TP53, FGFR3, AXIN2, CTNNB1, DCC, PTPRJ, KAT5, EP300
nucleobase-containing compound catabolic process (GO:0034655)	NEW	3.9	0.0	BAX, PIK3CA, AKT1, NRAS, DLC1, CCND1, AURKA, TRIM28, TP53, RAD54B, TLR2, CTNNB1, TLR4, DCC, EP300, BRAF, MLH3
regulation of protein kinase B signaling (GO:0051896)	-	4.92	0.0	BAX, PTPN12, AURKA, PIK3CA, AXIN2, AKT1, PTPRJ, FLCN
regulation of transmembrane transport (GO:0034762)	-	3.74	0.006	BAX, CTNNB1, CCND1, DLC1, TP53, TLR4, AKT1, ODC1, BRAF, TLR2
hormone-mediated signaling pathway (GO:0009755)	-	4.66	0.009	AKT1, CCND1, TRIM28, CTNNB1, KAT5, EP300
regulation of actin filament bundle assembly (GO:0032231)	-	5.37	0.006	CTNNB1, CCND1, AKT1, DCC, BRAF, DLC1
response to inorganic substance (GO:0010035)	-	3.56	0.0	MT-CO1, CTNNB1, DLC1, CCND1, BUB1B, BAX, TP53, RAD54B, PIK3CA, AKT1, TLR4, EP300, BRAF, TLR2
negative regulation of macromolecule metabolic process (GO:0010605)	-	2.01	0.001	APC, BAX, AKT1, CCND1, BUB1B, TP53, FGFR3, PTPRJ, TRIM28, CTNNB1, KAT5, EP300, FLCN
positive regulation of macromolecule metabolic process (GO:0010604)	-	1.81	0.0	APC, BAX, TLR2, AKT1, NRAS, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, FLCN
taxis (GO:0042330)	NEW	4.03	0.0	BAX, AKT1, PTPN12, CCND1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, TLR2
cellular macromolecule localization (GO:0070727)	-	3.1	0.003	AKT1, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, PTPRJ, EP300, TLR4
response to virus (GO:0009615)	NEW	4.21	0.007	BAX, CCND1, DLC1, PIK3CA, TP53, AKT1, ODC1, EP300, TLR4
response to bacterium (GO:0009617)	-	4.18	0.0	TLR2, CTNNB1, PLA2G2A, DLC1, TP53, PIK3CA, AKT1, KAT5, EP300, TLR4
protein modification by small protein conjugation or removal (GO:0070647)	-	2.95	0.001	APC, BAX, AKT1, CCND1, AURKA, TP53, RAD54B, TRIM28, CTNNB1, KAT5, EP300, BRAF, TLR4
response to wounding (GO:0009611)	NEW	4.39	0.001	BAX, AKT1, CCND1, TP53, FGFR3, CTNNB1, EP300, BRAF, TLR4
peptidyl-amino acid modification (GO:0018193)	-	2.98	0.0	AKT1, AURKA, CCND1, DLC1, PIK3CA, FGFR3, PTPRJ, TP53, CTNNB1, DCC, AXIN2, KAT5, EP300, ODC1, TLR4
positive regulation of transcription factor import into nucleus (GO:0042993)	-	5.78	0.004	KAT5, TRIM28, AKT1, TLR2, TLR4
interspecies interaction between organisms (GO:0044419)	-	3.08	0.0	BAX, AKT1, DLC1, CCND1, TRIM28, TP53, RAD54B, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
positive regulation of lipid metabolic process (GO:0045834)	-	4.88	0.029	CCND1, TP53, FGFR3, AKT1, EP300, TLR4
TRIF-dependent toll-like receptor signaling pathway (GO:0035666)	NEW	6.43	0.007	TP53, CCND1, AKT1, TLR2, TLR4
negative regulation of mitosis (GO:0045839)	-	6.26	0.0	APC, BUB1B, CCND1, AURKA, FGFR3, AKT1
positive regulation of NF-kappaB import into nucleus (GO:0042346)	-	6.43	0.019	TRIM28, AKT1, TLR2, TLR4
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.002	AKT1, NRAS, CCND1, AURKA, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.0	MT-CO1, AKT1, NRAS, AURKA, CCND1, TRIM28, BAX, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.002	AKT1, NRAS, AURKA, CCND1, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
thymus development (GO:0048538)	-	5.88	0.0	APC, CTNNB1, CCND1, TP53, FGFR3, AKT1, EP300
regulation of macromolecule metabolic process (GO:0060255)	-	1.08	0.0	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
response to corticosteroid (GO:0031960)	-	4.56	0.009	CTNNB1, CCND1, TP53, AKT1, DCC, EP300, BRAF, TLR4
regulation of Ras protein signal transduction (GO:0046578)	-	4.49	0.004	NRAS, DLC1, TP53, PIK3CA, AKT1, DCC, FLCN
regulation of muscle organ development (GO:0048634)	NEW	5.07	0.016	CTNNB1, NRAS, CCND1, TP53, AKT1, KAT5, EP300
regulation of peptide hormone secretion (GO:0090276)	NEW	4.41	0.021	BAX, AKT1, CCND1, TP53, CTNNB1, ODC1, EP300, TLR4
lymphocyte activation (GO:0046649)	-	3.96	0.0	APC, BAX, AKT1, CCND1, TP53, ODC1, TRIM28, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
regulation of proteolysis (GO:0030162)	-	3.2	0.0	APC, PLA2G2A, BAX, PIK3CA, CTNNB1, DLC1, EP300, CCND1, AURKA, TP53, PTPRJ, TLR2, PTPN12, TLR4, DCC, KAT5, AKT1, BRAF, FLCN
protein catabolic process (GO:0030163)	-	3.93	0.0	BAX, AURKA, CCND1, BUB1B, TP53, TRIM28, AKT1, KAT5, EP300, BRAF
regulation of neuron projection development (GO:0010975)	-	3.69	0.004	PTPN12, CCND1, AURKA, PIK3CA, AXIN2, TP53, AKT1, DCC, EP300, BRAF, DLC1
negative regulation of protein serine/threonine kinase activity (GO:0071901)	-	4.92	0.037	APC, CCND1, PIK3CA, PTPRJ, TP53, AKT1
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.001	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
cytokinesis (GO:0000910)	NEW	5.22	0.0	APC, BUB1B, AURKA, TP53, AKT1, EP300, DLC1
negative regulation of apoptotic signaling pathway (GO:2001234)	-	4.42	0.013	BAX, AKT1, CCND1, TP53, AXIN2, CTNNB1, KAT5, TLR4
cell motility (GO:0048870)	-	3.02	0.0	APC, BAX, TLR2, CTNNB1, NRAS, DLC1, EP300, CCND1, AURKA, TP53, PIK3CA, TRIM28, PTPN12, TLR4, DCC, KAT5, AKT1, MLH3
positive regulation of type I interferon production (GO:0032481)	-	5.48	0.018	TLR4, EP300, AKT1, CTNNB1, TLR2
chemical homeostasis (GO:0048878)	-	2.97	0.009	BAX, AKT1, PLA2G2A, AURKA, TP53, BRAF, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, CCND1, TLR2
purine nucleotide metabolic process (GO:0006163)	NEW	4.09	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, MLH3
extracellular matrix organization (GO:0030198)	NEW	4.01	0.002	BAX, AKT1, PTPN12, CCND1, AURKA, PIK3CA, TP53, CTNNB1, KAT5, BRAF, TLR4
axis specification (GO:0009798)	-	5.42	0.015	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, EP300
positive regulation of interleukin-12 production (GO:0032735)	-	6.23	0.02	EP300, AKT1, TLR2, TLR4
response to light stimulus (GO:0009416)	-	4.08	0.025	BAX, AKT1, NRAS, CCND1, AURKA, TP53, CTNNB1, KAT5, EP300, BRAF
cardiac septum morphogenesis (GO:0060411)	NEW	5.9	0.011	AKT1, CCND1, EP300, TP53, CTNNB1
regulation of mitotic cell cycle phase transition (GO:1901990)	-	4.23	0.0	APC, AKT1, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300, DLC1
negative regulation of protein transport (GO:0051224)	NEW	4.44	0.021	CTNNB1, TP53, AXIN2, AKT1, KAT5, EP300, TLR4
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124)	NEW	8.34	0.007	CCND1, AKT1, TP53, TLR2, TLR4
regulation of chemokine production (GO:0032642)	-	5.54	0.019	TP53, CCND1, TLR2, AKT1, TLR4
regulation of kidney development (GO:0090183)	-	5.72	0.025	TP53, FLCN, EP300, AKT1, CTNNB1
mononuclear cell proliferation (GO:0032943)	-	5.32	0.006	BAX, CTNNB1, TP53, AKT1, EP300, TLR4
microtubule cytoskeleton organization (GO:0000226)	NEW	4.13	0.002	APC, CTNNB1, AURKA, CCND1, BUB1B, TP53, AKT1, KAT5, EP300
defense response to bacterium (GO:0042742)	-	4.31	0.0	TLR2, CTNNB1, PLA2G2A, DLC1, PIK3CA, TP53, AKT1, KAT5, EP300, TLR4
regulation of mononuclear cell proliferation (GO:0032944)	-	4.45	0.001	CTNNB1, CCND1, DLC1, TP53, PIK3CA, AKT1, TLR4, EP300, TLR2
actin filament-based process (GO:0030029)	NEW	3.94	0.003	CTNNB1, NRAS, PTPN12, BRAF, DLC1, PIK3CA, TP53, AKT1, EP300, TLR4
mitotic nuclear division (GO:0007067)	-	4.05	0.015	BUB1B, CCND1, AURKA, TP53, PTPRJ, AKT1, EP300, DLC1
regulation of sister chromatid cohesion (GO:0007063)	-	6.9	0.0	APC, AXIN2, PTPRJ, CTNNB1
positive regulation of cytokine biosynthetic process (GO:0042108)	NEW	5.65	0.036	CCND1, TLR2, TP53, AKT1, TLR4
regulation of mitotic cell cycle (GO:0007346)	-	3.71	0.0	APC, AKT1, AURKA, CCND1, BUB1B, TP53, FGFR3, PTPRJ, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, DLC1
regulation of protein secretion (GO:0050708)	-	3.77	0.002	PTPN12, CCND1, DLC1, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
regulation of cellular protein catabolic process (GO:1903362)	-	4.23	0.035	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1
negative regulation of muscle tissue development (GO:1901862)	NEW	6.17	0.004	CCND1, EP300, NRAS, AKT1
cellular response to tumor necrosis factor (GO:0071356)	NEW	5.19	0.0	CCND1, PIK3CA, TP53, TRIM28, AKT1, KAT5, EP300, BRAF
regulation of peptidase activity (GO:0052547)	-	3.75	0.0	APC, BAX, CTNNB1, DLC1, PLA2G2A, AURKA, TP53, BRAF, TLR2, AKT1, TLR4, KAT5, CCND1, FLCN
gonad development (GO:0008406)	NEW	4.92	0.01	AKT1, CCND1, TRIM28, TP53, PIK3CA, CTNNB1, EP300
cellular component organization (GO:0016043)	-	1.24	0.004	APC, BAX, AKT1, NRAS, DLC1, AURKA, PLA2G2A, BUB1B, TRIM28, FGFR3, TP53, AXIN2, MLH3, CTNNB1, DCC, KAT5, EP300, BRAF, FLCN
macromolecular complex assembly (GO:0065003)	-	2.55	0.001	APC, MT-CO1, AKT1, PTPN12, AURKA, CCND1, BUB1B, BAX, TP53, RAD54B, TRIM28, CTNNB1, PIK3CA, DLC1, KAT5, EP300, BRAF, TLR4
regulation of cell-substrate adhesion (GO:0010810)	-	4.56	0.0	AKT1, CCND1, AURKA, TP53, PTPRJ, DLC1, CTNNB1, KAT5, BRAF, TLR4
cellular response to oxygen levels (GO:0071453)	-	4.97	0.002	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300
leukocyte activation involved in immune response (GO:0002366)	NEW	4.88	0.005	CTNNB1, TP53, TLR4, AKT1, KAT5, EP300, TLR2
regulation of platelet activation (GO:0010543)	NEW	6.26	0.034	PLA2G2A, TP53, AKT1, TLR4
cellular response to hypoxia (GO:0071456)	-	5.11	0.001	BAX, CTNNB1, CCND1, TP53, AKT1, KAT5, EP300
skeletal muscle cell differentiation (GO:0035914)	NEW	5.74	0.0	APC, CTNNB1, CCND1, TP53, AKT1, EP300
regulation of molecular function (GO:0065009)	-	1.78	0.0	APC, BAX, NRAS, DLC1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, AKT1, TLR4, PTPRJ, EP300, BRAF, TLR2
regulation of biological quality (GO:0065008)	-	1.68	0.001	APC, BAX, AKT1, NRAS, DLC1, CCND1, AURKA, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, TLR2
sprouting angiogenesis (GO:0002040)	NEW	6.51	0.005	CCND1, AKT1, TP53, CTNNB1
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.003	AKT1, NRAS, CCND1, AURKA, TRIM28, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.003	AKT1, NRAS, CCND1, AURKA, TP53, RAD54B, TRIM28, PIK3CA, CTNNB1, TLR4, DCC, BRAF, MLH3
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.0	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, MLH3
regulation of cell cycle phase transition (GO:1901987)	-	4.15	0.0	APC, AKT1, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300, DLC1
protein modification process (GO:0036211)	-	1.79	0.024	PTPN12, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, PTPRJ, TRIM28, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
regulation of protein binding (GO:0043393)	-	4.6	0.0	BAX, CTNNB1, CCND1, AURKA, TRIM28, TP53, AKT1, EP300, TLR2
regulation of protein acetylation (GO:1901983)	-	5.59	0.0	CCND1, TP53, TLR4, AKT1, EP300, FLCN
toll-like receptor 4 signaling pathway (GO:0034142)	NEW	6.84	0.041	TP53, CCND1, AKT1, TLR2, TLR4
regulation of protein complex assembly (GO:0043254)	-	3.83	0.0	APC, BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, DCC, KAT5, EP300, TLR4
regulation of macrophage activation (GO:0043030)	NEW	6.43	0.023	CCND1, EP300, PLA2G2A, KAT5
negative regulation of cell cycle phase transition (GO:1901988)	-	4.74	0.0	APC, AKT1, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300
regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	NEW	6.02	0.018	FGFR3, AKT1, TP53, PIK3CA
regulation of lipid kinase activity (GO:0043550)	NEW	5.84	0.001	FGFR3, CCND1, AKT1, TP53, PIK3CA
cell fate commitment (GO:0045165)	NEW	4.72	0.021	CTNNB1, CCND1, TP53, FGFR3, AKT1, EP300, TLR4
Fc receptor signaling pathway (GO:0038093)	-	4.45	0.033	NRAS, PIK3CA, FGFR3, TP53, AKT1, DCC, EP300, TLR4
response to nitrogen compound (GO:1901698)	-	3.12	0.0	APC, BAX, AKT1, NRAS, DLC1, CCND1, BUB1B, TP53, FGFR3, ODC1, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
regulation of protein stability (GO:0031647)	-	4.33	0.009	CTNNB1, CCND1, AURKA, TP53, AKT1, EP300, BRAF
regulation of myelination (GO:0031641)	-	6.23	0.01	CCND1, EP300, NRAS, CTNNB1
positive regulation of protein catabolic process (GO:0045732)	-	4.18	0.0	APC, CCND1, AURKA, PIK3CA, TP53, TRIM28, AKT1, ODC1, TLR4
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4, ODC1, EP300, BRAF, TLR2
positive regulation of DNA repair (GO:0045739)	NEW	6.09	0.008	KAT5, EP300, TP53, TRIM28
regulation of cell cycle checkpoint (GO:1901976)	NEW	6.36	0.007	BUB1B, AURKA, EP300, AKT1
negative regulation of cell growth (GO:0030308)	-	4.58	0.0	AKT1, CCND1, TRIM28, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, FLCN
dephosphorylation (GO:0016311)	-	4.06	0.0	AKT1, PTPN12, CCND1, AURKA, TP53, PTPRJ, TLR4, CTNNB1, DLC1, EP300, MLH3
phosphorylation (GO:0016310)	-	2.63	0.0	MT-CO1, AKT1, BUB1B, TP53, KAT5, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1, MLH3
tube formation (GO:0035148)	-	4.98	0.005	CTNNB1, CCND1, TP53, DLC1, AKT1, EP300, TLR4
positive regulation of signaling (GO:0023056)	-	2.41	0.002	BAX, TLR2, NRAS, BRAF, TP53, FGFR3, PTPRJ, TLR4, CTNNB1, DCC, FLCN
cell-cell signaling (GO:0007267)	-	3.35	0.0	MT-CO1, AKT1, DLC1, CCND1, BUB1B, BAX, TP53, FGFR3, ODC1, AXIN2, PIK3CA, CTNNB1, KAT5, EP300, BRAF, TLR4
signaling (GO:0023052)	-	3.25	0.0	MT-CO1, AKT1, DLC1, CCND1, BUB1B, BAX, TP53, FGFR3, ODC1, AXIN2, PIK3CA, CTNNB1, KAT5, EP300, BRAF, TLR4
negative regulation of cell communication (GO:0010648)	-	2.66	0.0	APC, BAX, TLR2, AKT1, NRAS, AURKA, CCND1, DLC1, MCC, FGFR3, PIK3CA, AXIN2, TP53, CTNNB1, TLR4, DCC, PTPRJ, KAT5, EP300, BRAF, FLCN
regulation of signaling (GO:0023051)	-	1.72	0.0	APC, BAX, TLR2, AKT1, NRAS, CCND1, DLC1, MCC, FGFR3, AXIN2, TP53, CTNNB1, TLR4, DCC, PTPRJ, EP300, BRAF, FLCN
axon guidance (GO:0007411)	-	4.44	0.001	AKT1, NRAS, PLA2G2A, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, DCC, KAT5, EP300, CCND1
ameboidal cell migration (GO:0001667)	NEW	4.71	0.003	BAX, CTNNB1, CCND1, PIK3CA, TP53, AKT1, EP300, TLR4
regulation of cell communication (GO:0010646)	-	1.73	0.0	APC, BAX, TLR2, CTNNB1, NRAS, CCND1, DLC1, MCC, FGFR3, AXIN2, TP53, AKT1, TLR4, DCC, PTPRJ, EP300, BRAF, FLCN
purine nucleoside monophosphate metabolic process (GO:0009126)	NEW	4.69	0.017	MT-CO1, AKT1, CCND1, AURKA, BAX, TP53, RAD54B, TLR4, CTNNB1, MLH3
negative regulation of catalytic activity (GO:0043086)	-	3.0	0.0	APC, BAX, AKT1, AURKA, CCND1, BUB1B, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, ODC1, EP300, KAT5, FLCN
regulation of centromeric sister chromatid cohesion (GO:0070602)	-	8.63	0.017	AXIN2, CTNNB1
regulation of cell-matrix adhesion (GO:0001952)	-	5.21	0.0	CTNNB1, CCND1, TP53, PTPRJ, TLR4, AKT1, DLC1
regulation of DNA-templated transcription in response to stress (GO:0043620)	-	5.52	0.002	APC, CCND1, EP300, TP53, AKT1
regulation of programmed cell death (GO:0043067)	-	2.49	0.0	APC, BAX, AKT1, NRAS, AURKA, BRAF, DLC1, TP53, FGFR3, PIK3CA, CTNNB1, DCC, FLCN
response to hexose (GO:0009746)	-	4.82	0.01	BAX, AKT1, CCND1, TP53, CTNNB1, EP300, TLR4
heart development (GO:0007507)	-	4.24	0.012	CTNNB1, CCND1, BUB1B, TP53, PTPRJ, AKT1, KAT5, EP300
multicellular organismal process (GO:0032501)	-	1.45	0.014	APC, BAX, AKT1, NRAS, CCND1, AURKA, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, PTPRJ, EP300, PLA2G2A, TLR4
regulation of response to stimulus (GO:0048583)	-	1.54	0.0	APC, PLA2G2A, BAX, TLR2, CTNNB1, NRAS, CCND1, DLC1, MCC, FGFR3, TLR4, TP53, AXIN2, TRIM28, AKT1, PIK3CA, DCC, PTPRJ, EP300, BRAF, FLCN
positive regulation of cell differentiation (GO:0045597)	-	3.01	0.009	APC, CTNNB1, PTPN12, PLA2G2A, AURKA, TP53, BRAF, FGFR3, TLR4, AXIN2, TRIM28, AKT1, PIK3CA, DCC, PTPRJ, KAT5, EP300, CCND1, TLR2
negative regulation of cell differentiation (GO:0045596)	-	3.33	0.0	APC, AKT1, NRAS, PTPN12, PLA2G2A, TP53, BRAF, FGFR3, AXIN2, PIK3CA, CTNNB1, DCC, KAT5, EP300, CCND1, TLR4
regulation of cell differentiation (GO:0045595)	-	2.42	0.0	APC, BAX, CTNNB1, NRAS, CCND1, AURKA, TP53, BRAF, FGFR3, AXIN2, TLR2, AKT1, TLR4, DCC, PLA2G2A, FLCN
microtubule-based process (GO:0007017)	NEW	3.54	0.004	APC, AKT1, AURKA, CCND1, BUB1B, TP53, DLC1, CTNNB1, KAT5, EP300, TLR2
negative regulation of transcription, DNA-templated (GO:0045892)	-	2.75	0.001	APC, BAX, AKT1, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, FLCN
response to acid chemical (GO:0001101)	NEW	4.05	0.0	BAX, AKT1, DLC1, CCND1, BUB1B, TP53, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	-	4.88	0.035	BAX, CCND1, TP53, TLR4, AKT1, DLC1
cytoskeleton organization (GO:0007010)	-	3.22	0.0	APC, BAX, AKT1, NRAS, PTPN12, AURKA, CCND1, BUB1B, TP53, RAD54B, PIK3CA, CTNNB1, DLC1, KAT5, EP300, BRAF, TLR4
cellular chemical homeostasis (GO:0055082)	-	3.4	0.002	BAX, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
nucleobase-containing small molecule metabolic process (GO:0055086)	NEW	3.59	0.001	MT-CO1, AKT1, NRAS, CCND1, AURKA, BAX, TRIM28, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, KAT5, EP300, BRAF, MLH3
regulation of fat cell differentiation (GO:0045598)	NEW	5.04	0.001	CTNNB1, CCND1, TLR4, AKT1, KAT5, EP300, TLR2
negative regulation of developmental process (GO:0051093)	-	3.17	0.001	APC, CTNNB1, NRAS, EP300, CCND1, TP53, BRAF, FGFR3, AXIN2, PIK3CA, PTPN12, DCC, KAT5, AKT1, PLA2G2A, TLR4
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	-	4.85	0.035	CCND1, TP53, TLR4, AKT1, KAT5, TLR2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	-	4.29	0.003	CTNNB1, EP300, CCND1, TP53, TLR4, PTPN12, KAT5, AKT1, TLR2
regulation of cellular protein metabolic process (GO:0032268)	-	1.99	0.0	APC, BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, PTPRJ, EP300, BRAF, FLCN
aging (GO:0007568)	-	4.16	0.005	BAX, AKT1, PLA2G2A, TP53, CTNNB1, KAT5, EP300, CCND1, TLR4
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	-	5.44	0.012	AKT1, BAX, EP300, TP53, FLCN
positive regulation of developmental process (GO:0051094)	-	2.77	0.0	APC, BAX, AKT1, CCND1, AURKA, TRIM28, BRAF, FGFR3, TP53, AXIN2, TLR4, PTPN12, PIK3CA, DCC, PTPRJ, KAT5, CTNNB1, EP300, PLA2G2A, TLR2
response to hormone (GO:0009725)	-	3.33	0.001	APC, BAX, AKT1, NRAS, CCND1, TP53, BRAF, FGFR3, TLR4, PTPRJ, TRIM28, CTNNB1, PIK3CA, DCC, ODC1, EP300, KAT5, TLR2
positive regulation of binding (GO:0051099)	NEW	4.88	0.0	CCND1, AURKA, TRIM28, TP53, TLR4, AKT1, EP300, TLR2
regulation of binding (GO:0051098)	-	4.08	0.0	APC, BAX, AKT1, CCND1, AURKA, TRIM28, TP53, PTPRJ, TLR4, CTNNB1, KAT5, EP300, TLR2
morphogenesis of a branching structure (GO:0001763)	NEW	4.71	0.014	APC, AKT1, NRAS, CCND1, TP53, CTNNB1, DCC, EP300
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	-	2.81	0.0	APC, AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, TLR4, AXIN2, TLR2, CTNNB1, PIK3CA, DCC, KAT5, EP300, TRIM28, FLCN
lymphocyte differentiation (GO:0030098)	-	4.49	0.001	APC, CTNNB1, CCND1, TP53, TRIM28, AKT1, KAT5, EP300, BRAF
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.0	APC, BAX, CTNNB1, NRAS, EP300, CCND1, AURKA, TP53, BRAF, TLR4, PTPN12, PIK3CA, KAT5, AKT1, ODC1, TLR2
activation of MAPK activity (GO:0000187)	NEW	4.79	0.0	CTNNB1, CCND1, AURKA, TP53, TLR4, PTPN12, PIK3CA, AKT1, TLR2
developmental process (GO:0032502)	-	1.36	0.0	AKT1, TP53, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
response to extracellular stimulus (GO:0009991)	-	3.71	0.035	BAX, CTNNB1, CCND1, TP53, FLCN, AKT1, TLR4, KAT5, EP300, TLR2
regulation of cellular catabolic process (GO:0031329)	-	3.83	0.0	APC, BAX, AURKA, PIK3CA, CTNNB1, EP300, CCND1, DLC1, TP53, AXIN2, TRIM28, PTPN12, TLR4, DCC, PTPRJ, KAT5, AKT1, BRAF, FLCN
positive regulation of cellular metabolic process (GO:0031325)	-	1.81	0.0	BAX, TLR2, CTNNB1, NRAS, DLC1, CCND1, AURKA, TRIM28, FGFR3, TP53, AXIN2, PIK3CA, AKT1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
negative regulation of cellular metabolic process (GO:0031324)	-	2.01	0.0	APC, BAX, AKT1, CCND1, BUB1B, TP53, FGFR3, PTPRJ, TRIM28, CTNNB1, TLR4, KAT5, EP300, FLCN
regulation of cellular metabolic process (GO:0031323)	-	1.07	0.001	BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, AKT1, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
mitotic cell cycle process (GO:1903047)	-	3.12	0.0	APC, AKT1, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, ODC1, DLC1
negative regulation of cell cycle process (GO:0010948)	-	4.37	0.0	APC, AKT1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, TRIM28, CTNNB1, KAT5, EP300
spindle assembly involved in mitosis (GO:0090307)	NEW	6.17	0.03	AURKA, EP300, TP53
positive regulation of cell death (GO:0010942)	-	3.32	0.0	APC, BAX, AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, TLR4, AXIN2, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, PLA2G2A, FLCN
response to insulin (GO:0032868)	NEW	4.72	0.001	NRAS, CCND1, PIK3CA, FGFR3, PTPRJ, TP53, AKT1, DCC, EP300, TLR2
regulation of cell death (GO:0010941)	-	2.43	0.0	APC, BAX, AKT1, NRAS, DLC1, BRAF, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, DCC, FLCN
response to lipopolysaccharide (GO:0032496)	NEW	4.03	0.001	BAX, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
regulation of glial cell differentiation (GO:0045685)	NEW	5.63	0.034	FGFR3, CCND1, AKT1, CTNNB1, TLR2
morphogenesis of an epithelium (GO:0002009)	-	4.08	0.0	APC, CTNNB1, NRAS, EP300, CCND1, TRIM28, FGFR3, TP53, PTPN12, DCC, KAT5, AKT1
cellular response to light stimulus (GO:0071482)	-	5.22	0.0	BAX, AKT1, CCND1, AURKA, TP53, CTNNB1, BRAF
intracellular receptor signaling pathway (GO:0030522)	-	4.6	0.004	CTNNB1, CCND1, TP53, TRIM28, AKT1, KAT5, EP300, TLR2
growth (GO:0040007)	-	3.8	0.0	BAX, CTNNB1, DLC1, EP300, CCND1, AURKA, TP53, FGFR3, TLR4, PTPN12, KAT5, AKT1, MLH3
regulation of cellular component biogenesis (GO:0044087)	-	3.08	0.0	APC, BAX, AKT1, DLC1, CCND1, AURKA, PIK3CA, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
cellular response to organonitrogen compound (GO:0071417)	-	3.87	0.0	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, KAT5, TLR2
carbohydrate homeostasis (GO:0033500)	-	4.6	0.003	BAX, CTNNB1, NRAS, CCND1, TP53, PTPRJ, AKT1, EP300
bone mineralization (GO:0030282)	-	6.09	0.0	CTNNB1, CCND1, TP53, FGFR3, AXIN2, AKT1
negative regulation of cytokine production (GO:0001818)	-	4.4	0.008	CCND1, PIK3CA, TP53, AKT1, TLR4, KAT5, EP300, TLR2
mesenchymal cell proliferation (GO:0010463)	NEW	7.16	0.016	FGFR3, AKT1, CTNNB1
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.003	AKT1, NRAS, CCND1, AURKA, TRIM28, TP53, RAD54B, TLR4, CTNNB1, PIK3CA, DCC, BRAF, MLH3
hematopoietic or lymphoid organ development (GO:0048534)	-	4.49	0.0	APC, AKT1, CCND1, TRIM28, FGFR3, TP53, PIK3CA, CTNNB1, EP300, FLCN
neuron development (GO:0048666)	NEW	4.8	0.004	CTNNB1, CCND1, AURKA, PIK3CA, TP53, AKT1, KAT5, EP300
regulation of tissue remodeling (GO:0034103)	NEW	5.55	0.002	BAX, CTNNB1, PTPN12, CCND1, TP53, AKT1
lung alveolus development (GO:0048286)	NEW	6.15	0.011	CCND1, AKT1, TP53, CTNNB1, TLR4
regulation of smooth muscle cell proliferation (GO:0048660)	NEW	5.1	0.008	CTNNB1, CCND1, TP53, TLR4, AKT1, TLR2
positive regulation of smooth muscle cell proliferation (GO:0048661)	NEW	5.6	0.007	CCND1, AKT1, TP53, TLR2, TLR4
positive regulation of cell growth (GO:0030307)	-	4.73	0.027	PLA2G2A, BUB1B, TP53, AKT1, KAT5, CCND1, TLR4
B cell proliferation (GO:0042100)	-	6.12	0.036	BAX, EP300, TLR4, CTNNB1
cellular macromolecule catabolic process (GO:0044265)	-	3.19	0.016	AKT1, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, PIK3CA, CTNNB1, KAT5, EP300, BRAF
biomineral tissue development (GO:0031214)	-	5.41	0.0	CTNNB1, CCND1, AURKA, TP53, FGFR3, AXIN2, AKT1, TLR4
cell adhesion (GO:0007155)	-	2.82	0.001	APC, PIK3CA, AKT1, CCND1, AURKA, TP53, FGFR3, TLR2, PTPN12, TLR4, DCC, KAT5, CTNNB1, EP300, BRAF, FLCN
cell communication (GO:0007154)	-	3.04	0.0	MT-CO1, AKT1, DLC1, CCND1, BUB1B, BAX, TP53, FGFR3, ODC1, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, FLCN
regulation of purine nucleotide metabolic process (GO:1900542)	NEW	4.41	0.0	APC, TLR2, AKT1, AURKA, CCND1, DLC1, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, PTPRJ, KAT5, BRAF, FLCN
odontogenesis of dentin-containing tooth (GO:0042475)	-	5.52	0.006	BAX, CTNNB1, TP53, AKT1, EP300, TLR4
cell part morphogenesis (GO:0032990)	-	3.99	0.003	APC, BAX, AKT1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, KAT5
nervous system development (GO:0007399)	-	3.53	0.0	APC, AKT1, CCND1, AURKA, TP53, FGFR3, TRIM28, CTNNB1, PIK3CA, DCC, KAT5, EP300, BRAF
odontogenesis (GO:0042476)	-	5.19	0.002	BAX, CTNNB1, TP53, AXIN2, AKT1, EP300, TLR4
modification of morphology or physiology of other organism (GO:0035821)	NEW	5.12	0.01	BAX, TP53, TLR4, AKT1, EP300, TLR2
positive regulation of endothelial cell proliferation (GO:0001938)	NEW	5.51	0.004	CTNNB1, CCND1, TP53, FGFR3, AKT1, EP300
regulation of cell growth (GO:0001558)	-	3.75	0.0	AKT1, AURKA, PLA2G2A, BUB1B, TRIM28, TP53, AXIN2, TLR4, CTNNB1, DCC, PTPRJ, KAT5, EP300, CCND1, FLCN
organelle fission (GO:0048285)	-	3.79	0.0	MT-CO1, AKT1, DLC1, AURKA, CCND1, BUB1B, BAX, TP53, PTPRJ, TRIM28, CTNNB1, KAT5, EP300, MLH3
activation of immune response (GO:0002253)	-	3.67	0.003	APC, BAX, AKT1, CCND1, DLC1, TP53, TLR4, PTPN12, PIK3CA, DCC, TLR2
immune effector process (GO:0002252)	-	3.58	0.002	APC, BAX, CTNNB1, PLA2G2A, TP53, PIK3CA, AKT1, TLR4, KAT5, EP300, CCND1, TLR2
negative regulation of protein phosphorylation (GO:0001933)	-	3.79	0.0	APC, BAX, AKT1, CCND1, PIK3CA, PTPRJ, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.0	AKT1, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
apoptotic process involved in development (GO:1902742)	NEW	6.68	0.0	BAX, AKT1, CCND1, TP53, CTNNB1, EP300

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	29	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, MCC, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
intracellular part (GO:0044424)	0.28	28	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, MCC, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
organelle (GO:0043226)	0.4	25	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PTPRJ, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, BRAF, MLH3
intracellular organelle (GO:0043229)	0.51	24	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, BRAF, MLH3
membrane-bounded organelle (GO:0043227)	0.47	24	MT-CO1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PTPRJ, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
cytoplasmic part (GO:0044444)	0.82	23	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, AXIN2, PTPN12, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
intracellular membrane-bounded organelle (GO:0043231)	0.6	23	MT-CO1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, DLC1, CTNNB1, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, AKT1, EP300, TLR2, AURKA, FGFR3, CCND1, MLH3
intracellular organelle part (GO:0044446)	0.81	21	APC, PLA2G2A, MT-CO1, TLR2, CTNNB1, NRAS, PTPN12, AURKA, CCND1, BUB1B, BAX, TP53, AXIN2, TRIM28, AKT1, TLR4, DLC1, KAT5, MCC, EP300, MLH3
membrane (GO:0016020)	0.68	21	APC, PLA2G2A, MT-CO1, TLR2, AKT1, NRAS, CCND1, DLC1, BAX, TP53, FGFR3, PIK3CA, AXIN2, MCC, PTPN12, TLR4, DCC, PTPRJ, CTNNB1, BRAF, FLCN
organelle part (GO:0044422)	0.79	21	APC, BAX, TLR2, CTNNB1, NRAS, EP300, AURKA, PLA2G2A, BUB1B, MT-CO1, TRIM28, TP53, AXIN2, MCC, PTPN12, TLR4, DLC1, KAT5, AKT1, CCND1, MLH3
cytoplasm (GO:0005737)	1.01	20	APC, BAX, TLR2, AKT1, DLC1, AURKA, CCND1, BUB1B, TP53, FGFR3, ODC1, AXIN2, MCC, PTPN12, TLR4, KAT5, CTNNB1, EP300, BRAF, FLCN
nucleus (GO:0005634)	1.07	19	APC, FGFR3, BAX, AKT1, EP300, AURKA, CCND1, BUB1B, TRIM28, TP53, RAD54B, AXIN2, MLH3, CTNNB1, DLC1, KAT5, MCC, BRAF, FLCN
protein complex (GO:0043234)	1.51	18	APC, BAX, AURKA, AKT1, PTPN12, MLH3, CCND1, BUB1B, MT-CO1, TRIM28, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
macromolecular complex (GO:0032991)	1.35	18	APC, MT-CO1, TLR2, AKT1, AURKA, CCND1, BUB1B, BAX, TP53, PIK3CA, AXIN2, TRIM28, PTPN12, TLR4, KAT5, CTNNB1, EP300, MLH3
cytosol (GO:0005829)	1.68	15	APC, BAX, CTNNB1, AURKA, CCND1, BUB1B, TP53, AXIN2, PIK3CA, PTPN12, DCC, ODC1, AKT1, BRAF, DLC1
plasma membrane (GO:0005886)	1.39	15	APC, PIK3CA, AKT1, NRAS, BRAF, MCC, FGFR3, AXIN2, TLR2, PTPN12, TLR4, DCC, PTPRJ, CTNNB1, FLCN
nuclear part (GO:0044428)	1.55	14	APC, BAX, AKT1, AURKA, CCND1, BUB1B, MCC, TRIM28, TP53, CTNNB1, AXIN2, KAT5, EP300, MLH3
membrane part (GO:0044425)	0.95	13	APC, MT-CO1, PLA2G2A, DLC1, BAX, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, TLR2
nucleoplasm (GO:0005654)	1.89	11	APC, AKT1, AURKA, CCND1, TRIM28, MCC, AXIN2, TP53, CTNNB1, KAT5, EP300
non-membrane-bounded organelle (GO:0043228)	1.76	11	APC, CTNNB1, AURKA, BUB1B, TP53, AXIN2, DLC1, PTPN12, KAT5, AKT1, MLH3
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	11	APC, CTNNB1, AURKA, BUB1B, TP53, AXIN2, DLC1, PTPN12, KAT5, AKT1, MLH3
cell projection (GO:0042995)	2.47	10	APC, PTPN12, BRAF, AURKA, MCC, PTPRJ, PIK3CA, CTNNB1, DCC, FLCN
chromosomal part (GO:0044427)	3.18	9	APC, BUB1B, AURKA, TP53, TRIM28, CTNNB1, KAT5, EP300, MLH3
vesicle (GO:0031982)	1.64	9	BAX, AKT1, NRAS, PLA2G2A, FGFR3, AXIN2, CTNNB1, PTPRJ, TLR2
cell junction (GO:0030054)	2.75	9	APC, CTNNB1, PTPN12, CCND1, FGFR3, PTPRJ, DLC1, AKT1, FLCN
integral component of membrane (GO:0016021)	1.14	8	MT-CO1, BAX, TP53, FGFR3, PTPRJ, TLR4, DCC, TLR2
cytoskeletal part (GO:0044430)	2.49	8	APC, CTNNB1, PTPN12, BUB1B, AURKA, AXIN2, AKT1, DLC1
perinuclear region of cytoplasm (GO:0048471)	3.35	8	BAX, BUB1B, PLA2G2A, AURKA, CTNNB1, KAT5, ODC1, TLR4
intrinsic component of membrane (GO:0031224)	1.13	8	MT-CO1, BAX, TP53, FGFR3, PTPRJ, TLR4, DCC, TLR2
cytoskeleton (GO:0005856)	2.55	7	APC, CTNNB1, AURKA, BUB1B, AXIN2, AKT1, DLC1
nuclear chromosome part (GO:0044454)	3.67	7	BUB1B, AURKA, TRIM28, TP53, CTNNB1, KAT5, MLH3
membrane protein complex (GO:0098796)	2.84	7	APC, MT-CO1, BAX, PIK3CA, TLR4, CTNNB1, TLR2
plasma membrane part (GO:0044459)	1.95	7	APC, FGFR3, PTPRJ, TLR2, CTNNB1, TLR4, DLC1
membrane-bounded vesicle (GO:0031988)	1.71	7	BAX, NRAS, PLA2G2A, FGFR3, AXIN2, CTNNB1, PTPRJ
neuron part (GO:0097458)	2.64	6	APC, BRAF, AURKA, AXIN2, CTNNB1, DCC
cell projection part (GO:0044463)	2.97	6	APC, CTNNB1, AURKA, PTPRJ, AKT1, DLC1
organelle membrane (GO:0031090)	1.97	6	APC, MT-CO1, NRAS, BAX, TLR4, TLR2
cell-cell junction (GO:0005911)	3.85	6	APC, CTNNB1, CCND1, PTPRJ, AKT1, FLCN
microtubule organizing center (GO:0005815)	3.42	6	APC, CTNNB1, AURKA, BUB1B, AXIN2, AKT1
extracellular organelle (GO:0043230)	1.89	5	PLA2G2A, PTPRJ, NRAS, CTNNB1, BAX
catalytic complex (GO:1902494)	2.9	5	BUB1B, CCND1, EP300, KAT5, PIK3CA
anchoring junction (GO:0070161)	3.61	5	FGFR3, APC, DLC1, PTPN12, CTNNB1
transferase complex (GO:1990234)	3.32	5	BUB1B, CCND1, EP300, KAT5, PIK3CA
mitochondrion (GO:0005739)	2.42	5	MT-CO1, BRAF, BAX, TP53, AKT1
intracellular (GO:0005622)	2.37	5	CCND1, TRIM28, NRAS, PIK3CA, BAX
adherens junction (GO:0005912)	3.66	5	FGFR3, APC, DLC1, PTPN12, CTNNB1
transcription factor complex (GO:0005667)	4.1	5	TRIM28, KAT5, EP300, TP53, CTNNB1
extracellular vesicle (GO:1903561)	1.89	5	PLA2G2A, PTPRJ, NRAS, CTNNB1, BAX
extracellular region part (GO:0044421)	1.57	5	PLA2G2A, PTPRJ, NRAS, CTNNB1, BAX
extracellular exosome (GO:0070062)	1.89	5	PLA2G2A, PTPRJ, NRAS, CTNNB1, BAX
plasma membrane region (GO:0098590)	2.97	4	APC, PTPRJ, DLC1, CTNNB1
endoplasmic reticulum (GO:0005783)	2.56	4	FGFR3, PLA2G2A, BAX, TP53
Golgi apparatus (GO:0005794)	2.7	4	FGFR3, AXIN2, NRAS, TLR2
lamellipodium (GO:0030027)	4.73	4	APC, MCC, PIK3CA, CTNNB1
cytoplasmic vesicle (GO:0031410)	2.87	4	FGFR3, PLA2G2A, AXIN2, TLR2
bounding membrane of organelle (GO:0098588)	2.39	4	BAX, NRAS, TLR2, TLR4
cell projection membrane (GO:0031253)	4.11	4	APC, PTPRJ, DLC1, CTNNB1
chromatin (GO:0000785)	3.99	4	TP53, EP300, TRIM28, CTNNB1
intracellular vesicle (GO:0097708)	2.86	4	FGFR3, PLA2G2A, AXIN2, TLR2
neuron projection (GO:0043005)	3.12	4	APC, DCC, BRAF, CTNNB1
centrosome (GO:0005813)	3.75	4	APC, AURKA, AXIN2, CTNNB1
integral component of plasma membrane (GO:0005887)	2.57	4	FGFR3, PTPRJ, TLR4, TLR2
cell-substrate adherens junction (GO:0005924)	3.83	4	FGFR3, DLC1, PTPN12, CTNNB1
focal adhesion (GO:0005925)	3.83	4	FGFR3, DLC1, PTPN12, CTNNB1
intrinsic component of plasma membrane (GO:0031226)	2.53	4	FGFR3, PTPRJ, TLR4, TLR2
cell surface (GO:0009986)	3.44	4	FGFR3, PTPRJ, TLR4, TLR2
cell-substrate junction (GO:0030055)	3.82	4	FGFR3, DLC1, PTPN12, CTNNB1
RNA polymerase II transcription factor complex (GO:0090575)	5.18	3	TP53, TRIM28, CTNNB1
microtubule cytoskeleton (GO:0015630)	4.78	3	AURKA, AXIN2, AKT1
supramolecular fiber (GO:0099512)	3.31	3	APC, AURKA, AXIN2
polymeric cytoskeletal fiber (GO:0099513)	3.31	3	APC, AURKA, AXIN2
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	FGFR3, PLA2G2A, AXIN2
leading edge membrane (GO:0031256)	4.9	3	APC, PTPRJ, DLC1
occluding junction (GO:0070160)	5.07	3	APC, CCND1, CTNNB1
cytoplasmic region (GO:0099568)	4.51	3	APC, AXIN2, CTNNB1
nuclear chromatin (GO:0000790)	4.42	3	TRIM28, TP53, CTNNB1
bicellular tight junction (GO:0005923)	5.09	3	APC, CCND1, CTNNB1
plasma membrane protein complex (GO:0098797)	3.55	3	APC, CTNNB1, TLR2
nuclear transcription factor complex (GO:0044798)	4.95	3	TRIM28, TP53, CTNNB1
beta-catenin destruction complex (GO:0030877)	7.09	3	APC, AXIN2, CTNNB1
nucleoplasm part (GO:0044451)	3.22	3	KAT5, EP300, TP53
mitochondrial part (GO:0044429)	2.92	3	MT-CO1, BAX, TP53
extracellular region (GO:0005576)	2.18	3	FGFR3, PLA2G2A, PDGFRL
whole membrane (GO:0098805)	2.85	3	BAX, TLR4, TLR2
microtubule (GO:0005874)	3.81	3	APC, AURKA, AXIN2
ruffle membrane (GO:0032587)	5.42	3	APC, PTPRJ, DLC1
cell cortex (GO:0005938)	4.78	3	APC, AXIN2, CTNNB1
protein acetyltransferase complex (GO:0031248)	5.21	2	KAT5, EP300
endoplasmic reticulum membrane (GO:0005789)	2.95	2	PLA2G2A, BAX
synapse (GO:0045202)	3.58	2	APC, CTNNB1
cilium (GO:0005929)	3.89	2	AURKA, FLCN
catenin complex (GO:0016342)	7.61	2	APC, CTNNB1
spindle (GO:0005819)	4.52	2	AURKA, AKT1
nuclear euchromatin (GO:0005719)	6.54	2	TRIM28, CTNNB1
histone acetyltransferase complex (GO:0000123)	5.32	2	KAT5, EP300
nucleolus (GO:0005730)	3.06	2	KAT5, TP53
Wnt signalosome (GO:1990909)	7.4	2	APC, CTNNB1
spindle pole (GO:0000922)	5.08	2	AURKA, CTNNB1
endoplasmic reticulum part (GO:0044432)	2.73	2	PLA2G2A, BAX
synapse part (GO:0044456)	3.42	2	AXIN2, AKT1
kinetochore (GO:0000776)	5.05	2	APC, BUB1B
chromosome (GO:0005694)	3.78	2	BUB1B, MLH3
acetyltransferase complex (GO:1902493)	5.21	2	KAT5, EP300
lateral plasma membrane (GO:0016328)	5.89	2	APC, CTNNB1
transferase complex, transferring phosphorus-containing groups (GO:0061695)	4.61	2	CCND1, PIK3CA
cell-cell contact zone (GO:0044291)	5.69	2	FLCN, CTNNB1
membrane region (GO:0098589)	3.95	2	DLC1, TLR2
cell body (GO:0044297)	3.74	2	APC, BRAF
mitochondrial membrane (GO:0031966)	3.31	2	MT-CO1, BAX
cytoplasmic microtubule (GO:0005881)	5.74	2	APC, AXIN2
euchromatin (GO:0000791)	6.31	2	TRIM28, CTNNB1
cell-cell adherens junction (GO:0005913)	5.81	2	APC, CTNNB1
spindle midzone (GO:0051233)	6.51	2	BUB1B, AURKA
chromosome, centromeric region (GO:0000775)	4.85	2	BUB1B, AURKA
chromosomal region (GO:0098687)	4.19	2	BUB1B, AURKA
receptor complex (GO:0043235)	4.01	2	TLR4, TLR2
protein-DNA complex (GO:0032993)	5.03	2	EP300, CTNNB1
membrane raft (GO:0045121)	4.18	2	DLC1, TLR2
midbody (GO:0030496)	4.95	2	AURKA, FLCN
germ cell nucleus (GO:0043073)	6.76	2	AURKA, MLH3
axon part (GO:0033267)	4.4	2	APC, AURKA
membrane microdomain (GO:0098857)	4.17	2	DLC1, TLR2
mitochondrial protein complex (GO:0098798)	4.78	2	MT-CO1, BAX

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
membrane-enclosed lumen (GO:0031974)	NEW	3.05	0.005	APC, BAX, AKT1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
cell junction (GO:0030054)	-	2.75	0.0	APC, BAX, AKT1, PTPN12, CCND1, AURKA, PIK3CA, BRAF, FGFR3, PTPRJ, TP53, CTNNB1, TLR4, DCC, KAT5, EP300, DLC1, MLH3
cell-substrate junction (GO:0030055)	-	3.82	0.0	AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, DLC1, CTNNB1, DCC, BRAF, TLR4
vesicle (GO:0031982)	-	1.64	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
vacuole (GO:0005773)	NEW	2.92	0.013	BAX, PTPN12, PIK3CA, FGFR3, TP53, AKT1, TLR4, TLR2
membrane (GO:0016020)	-	0.68	0.013	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, MCC, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
spindle pole (GO:0000922)	-	5.08	0.009	APC, TP53, AURKA, AKT1, CTNNB1
beta-catenin destruction complex (GO:0030877)	-	7.09	0.0	APC, AXIN2, CTNNB1
Golgi lumen (GO:0005796)	NEW	5.28	0.015	TP53, CCND1, AKT1, CTNNB1, TLR2
catalytic complex (GO:1902494)	-	2.9	0.013	BAX, AKT1, CCND1, BUB1B, PIK3CA, TP53, TRIM28, CTNNB1, KAT5, EP300, BRAF, TLR4
cell body (GO:0044297)	-	3.74	0.0	BAX, AKT1, DLC1, CCND1, BUB1B, TP53, ODC1, TLR4, CTNNB1, KAT5, EP300, BRAF, TLR2
axonal growth cone (GO:0044295)	NEW	6.81	0.008	APC, AKT1, CTNNB1
mitochondrial membrane (GO:0031966)	-	3.31	0.018	MT-CO1, CTNNB1, CCND1, BAX, TP53, TLR4, AKT1, ODC1, TLR2
nuclear chromatin (GO:0000790)	-	4.42	0.0	AKT1, CCND1, TP53, TRIM28, CTNNB1, KAT5, EP300, TLR4
dendrite (GO:0030425)	NEW	3.92	0.05	APC, AKT1, TP53, TRIM28, CTNNB1, KAT5, ODC1, TLR4
transferase complex (GO:1990234)	-	3.32	0.011	BAX, AKT1, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300, BRAF
cell projection (GO:0042995)	-	2.47	0.0	APC, FGFR3, TP53, AKT1, PTPN12, EP300, CCND1, AURKA, TRIM28, BRAF, DLC1, RAD54B, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, ODC1, MCC, KAT5, TLR2
protein complex (GO:0043234)	-	1.51	0.001	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, BRAF, MLH3
organelle lumen (GO:0043233)	NEW	3.05	0.002	APC, BAX, AKT1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
cytosol (GO:0005829)	-	1.68	0.0	APC, BAX, AKT1, PTPN12, AURKA, CCND1, BUB1B, PIK3CA, BRAF, TP53, CTNNB1, DCC, KAT5, ODC1, DLC1
nuclear part (GO:0044428)	-	1.55	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, TLR4, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
chromosomal part (GO:0044427)	-	3.18	0.0	APC, AKT1, AURKA, CCND1, BUB1B, TRIM28, TP53, PTPRJ, TLR4, CTNNB1, KAT5, EP300, ODC1, MLH3
external side of plasma membrane (GO:0009897)	NEW	4.46	0.0	AKT1, CCND1, DLC1, TP53, PTPRJ, TLR4, CTNNB1, EP300, TLR2
chromatin (GO:0000785)	-	3.99	0.0	AKT1, CCND1, AURKA, TRIM28, PTPRJ, TP53, CTNNB1, KAT5, EP300, TLR4
nuclear chromosome (GO:0000228)	NEW	5.55	0.0	BUB1B, EP300, KAT5, AXIN2, TP53
focal adhesion (GO:0005925)	-	3.83	0.0	AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, DLC1, CTNNB1, DCC, BRAF, TLR4
nuclear speck (GO:0016607)	NEW	4.52	0.032	CTNNB1, CCND1, TP53, AKT1, EP300, TLR4
nuclear body (GO:0016604)	NEW	3.94	0.031	AKT1, CCND1, TRIM28, TP53, CTNNB1, KAT5, EP300, TLR4
blood microparticle (GO:0072562)	NEW	4.88	0.002	APC, AKT1, CCND1, TP53, CTNNB1, KAT5, ODC1
cytoplasmic vesicle part (GO:0044433)	NEW	3.41	0.004	BAX, AKT1, PTPN12, CCND1, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
Golgi apparatus part (GO:0044431)	NEW	3.0	0.008	APC, BAX, AKT1, NRAS, CCND1, DLC1, TRIM28, TP53, PIK3CA, CTNNB1, TLR4, ODC1, TLR2
cytoskeletal part (GO:0044430)	-	2.49	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, DLC1, CTNNB1, DCC, FLCN, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, CCND1
secretory granule (GO:0030141)	NEW	4.34	0.0	AKT1, PLA2G2A, TP53, PTPRJ, TLR4, PTPN12, ODC1, CCND1, TLR2
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.03	APC, CTNNB1, EP300, AURKA, CCND1, BUB1B, TP53, FGFR3, TRIM28, PTPN12, DLC1, KAT5, AKT1, ODC1, TLR4
nuclear matrix (GO:0016363)	NEW	5.22	0.0	CTNNB1, CCND1, BUB1B, TP53, TRIM28, AKT1, EP300
neuronal cell body (GO:0043025)	NEW	3.9	0.0	BAX, AKT1, DLC1, CCND1, BUB1B, TP53, TLR4, CTNNB1, KAT5, EP300, TLR2
leading edge membrane (GO:0031256)	-	4.9	0.001	APC, CTNNB1, AURKA, TP53, PTPRJ, AKT1, TLR4
anchoring junction (GO:0070161)	-	3.61	0.0	AKT1, PTPN12, CCND1, TP53, FGFR3, DLC1, CTNNB1, DCC, EP300, BRAF, TLR4
vesicle membrane (GO:0012506)	NEW	3.63	0.002	CTNNB1, EP300, CCND1, TP53, PTPRJ, TLR4, PTPN12, DCC, KAT5, AKT1, TLR2
spindle midzone (GO:0051233)	-	6.51	0.01	BUB1B, EP300, TP53
perikaryon (GO:0043204)	NEW	5.13	0.013	APC, ODC1, EP300, TLR4, AKT1
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.0	APC, PLA2G2A, BAX, PIK3CA, AKT1, CCND1, AURKA, TP53, FGFR3, PTPRJ, TLR2, PTPN12, TLR4, AXIN2, KAT5, CTNNB1, ODC1, FLCN
axon part (GO:0033267)	-	4.4	0.0	APC, CTNNB1, BUB1B, CCND1, AURKA, TP53, AKT1, EP300, TLR4
contractile fiber part (GO:0044449)	NEW	4.53	0.007	AKT1, CCND1, TP53, CTNNB1, DCC, KAT5, TLR2
lytic vacuole (GO:0000323)	NEW	3.89	0.048	BAX, PTPN12, PIK3CA, FGFR3, TLR4, AKT1, TLR2
extracellular matrix (GO:0031012)	NEW	3.81	0.0	AKT1, CCND1, AURKA, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, KAT5, ODC1, TLR2
microtubule (GO:0005874)	-	3.81	0.003	APC, CTNNB1, BUB1B, AURKA, TP53, AXIN2, AKT1, EP300, DLC1
apical part of cell (GO:0045177)	NEW	5.34	0.027	AURKA, TP53, EP300, AKT1, CTNNB1
organelle membrane (GO:0031090)	-	1.97	0.0	MT-CO1, AKT1, BUB1B, TP53, KAT5, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1, MLH3
nucleolus (GO:0005730)	-	3.06	0.013	CTNNB1, AURKA, CCND1, BUB1B, TP53, FGFR3, PIK3CA, PTPN12, DCC, KAT5, AKT1, TLR4
cytoplasmic vesicle (GO:0031410)	-	2.87	0.0	APC, BAX, TLR2, CTNNB1, PLA2G2A, AURKA, TP53, FGFR3, ODC1, RAD54B, AXIN2, PIK3CA, PTPN12, TLR4, PTPRJ, KAT5, AKT1, CCND1, FLCN
mitochondrion (GO:0005739)	-	2.42	0.001	MT-CO1, TLR2, AKT1, CCND1, AURKA, BAX, TP53, BRAF, TLR4, TRIM28, CTNNB1, PIK3CA, ODC1, KAT5, EP300, PLA2G2A, MLH3
nuclear chromosome part (GO:0044454)	-	3.67	0.0	AKT1, AURKA, CCND1, BUB1B, TRIM28, TP53, PTPRJ, TLR4, CTNNB1, KAT5, EP300, MLH3
synapse part (GO:0044456)	-	3.42	0.017	BAX, AKT1, CCND1, AURKA, TRIM28, AXIN2, TP53, CTNNB1, DCC, PTPRJ
neuron projection (GO:0043005)	-	3.12	0.0	APC, AKT1, CCND1, TP53, BRAF, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, DCC, ODC1, KAT5, TLR2
plasma membrane part (GO:0044459)	-	1.95	0.0	MT-CO1, AKT1, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1
cell surface (GO:0009986)	-	3.44	0.0	BAX, AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
cytoplasmic vesicle membrane (GO:0030659)	NEW	3.67	0.012	CTNNB1, EP300, CCND1, TP53, PTPRJ, TLR4, PTPN12, KAT5, AKT1, TLR2
adherens junction (GO:0005912)	-	3.66	0.003	AKT1, PTPN12, CCND1, TP53, FGFR3, DLC1, CTNNB1, DCC, BRAF, TLR4
cell-cell junction (GO:0005911)	-	3.85	0.01	APC, CTNNB1, CCND1, TP53, PTPRJ, AKT1, DCC, EP300, DLC1
cell projection part (GO:0044463)	-	2.97	0.005	APC, AKT1, DLC1, AURKA, CCND1, BUB1B, PIK3CA, PTPRJ, TP53, CTNNB1, DCC, ODC1, EP300, TLR4
actin cytoskeleton (GO:0015629)	NEW	4.39	0.001	AKT1, PTPN12, TRIM28, PTPRJ, CTNNB1, DCC, KAT5, EP300
endocytic vesicle (GO:0030139)	NEW	5.04	0.003	BAX, AKT1, PIK3CA, TP53, PTPN12, TLR4
cell periphery (GO:0071944)	NEW	5.78	0.031	CCND1, TP53, CTNNB1
side of membrane (GO:0098552)	NEW	4.22	0.0	AKT1, CCND1, DLC1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, EP300, TLR2
transport vesicle (GO:0030133)	NEW	4.3	0.025	APC, ODC1, TP53, CTNNB1, TLR4
cell-substrate adherens junction (GO:0005924)	-	3.83	0.0	AKT1, PTPN12, CCND1, AURKA, TP53, FGFR3, DLC1, CTNNB1, DCC, BRAF, TLR4
ruffle (GO:0001726)	NEW	5.28	0.012	DCC, CCND1, AURKA, TP53, AKT1
mitotic spindle (GO:0072686)	NEW	6.09	0.0	APC, AURKA, EP300, TP53, CTNNB1
extracellular space (GO:0005615)	NEW	2.63	0.0	APC, FGFR3, BAX, AKT1, PTPN12, AURKA, PLA2G2A, KAT5, TP53, BRAF, DLC1, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, CCND1, TLR2
centrosome (GO:0005813)	-	3.75	0.002	APC, CTNNB1, AURKA, BUB1B, TP53, AXIN2, AKT1, KAT5, EP300, ODC1
microtubule organizing center (GO:0005815)	-	3.42	0.0	APC, AKT1, DLC1, AURKA, BUB1B, TRIM28, AXIN2, TP53, CTNNB1, KAT5, EP300, ODC1, FLCN
neuron part (GO:0097458)	-	2.64	0.0	APC, FGFR3, BAX, AKT1, DLC1, AURKA, CCND1, BUB1B, TRIM28, BRAF, TP53, RAD54B, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, KAT5, TLR2
chromosome (GO:0005694)	-	3.78	0.001	CCND1, BUB1B, TP53, AXIN2, CTNNB1, KAT5, EP300
cytoskeleton (GO:0005856)	-	2.55	0.0	APC, CTNNB1, DLC1, EP300, CCND1, AURKA, TRIM28, TP53, PTPRJ, TLR4, PTPN12, DCC, KAT5, AKT1, MLH3
microtubule cytoskeleton (GO:0015630)	-	4.78	0.0	APC, CCND1, AURKA, TP53, PTPRJ, AKT1, EP300
transcriptional repressor complex (GO:0017053)	NEW	5.37	0.03	CCND1, EP300, TRIM28, TP53
lamellipodium (GO:0030027)	-	4.73	0.011	APC, AKT1, CCND1, MCC, PIK3CA, CTNNB1, DCC
cytoplasmic microtubule (GO:0005881)	-	5.74	0.0	APC, AXIN2, EP300, AURKA, TP53
spindle (GO:0005819)	-	4.52	0.0	APC, CTNNB1, AURKA, CCND1, BUB1B, TP53, AXIN2, AKT1, EP300, BRAF, DLC1
integral component of plasma membrane (GO:0005887)	-	2.57	0.0	APC, BAX, TLR2, CTNNB1, NRAS, PTPN12, CCND1, DLC1, TP53, FGFR3, PTPRJ, PIK3CA, AKT1, TLR4, DCC, ODC1, EP300, KAT5, FLCN
plasma membrane (GO:0005886)	-	1.39	0.0	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, MCC, AXIN2, TRIM28, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF
condensed chromosome kinetochore (GO:0000777)	NEW	5.31	0.017	APC, BUB1B, EP300, TP53
microvillus membrane (GO:0031528)	NEW	6.76	0.042	TP53, AKT1, CTNNB1
macromolecular complex (GO:0032991)	-	1.35	0.007	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, TLR4, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, BRAF, MLH3
pronucleus (GO:0045120)	NEW	7.03	0.007	AURKA, TP53, AKT1
membrane raft (GO:0045121)	-	4.18	0.002	BAX, DLC1, PIK3CA, TP53, AKT1, TLR4, DCC, TLR2
lysosome (GO:0005764)	NEW	3.89	0.048	BAX, AKT1, PIK3CA, FGFR3, TLR4, PTPN12, TLR2
intracellular organelle lumen (GO:0070013)	NEW	3.05	0.03	BAX, AKT1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, TLR2
extracellular region (GO:0005576)	-	2.18	0.0	APC, BAX, AKT1, PTPN12, AURKA, PDGFRL, KAT5, TP53, BRAF, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, CCND1, EP300, PLA2G2A, TLR2
proteinaceous extracellular matrix (GO:0005578)	NEW	4.01	0.0	AKT1, CCND1, AURKA, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, DCC, KAT5, TLR2