Disease table of COLORECTAL CANCER OMIM ID: 114500

Gene-disease associations table

Gene	Associated with COLORECTAL CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
MT-CO1	HUMSAVAR	HGNC link	MT	4	550500, 500008, 220110, 114500
BUB1B	OMIM	HGNC link	15q15.1	3	PS257300, 176430, 114500
MLH3	OMIM	HGNC link	14q24.3	3	114500, 608089, PS120435
BAX	OMIM	HGNC link	19q13.33	2	114500, 613065
PDGFRL	OMIM, HUMSAVAR	HGNC link	8p22	2	114550, 114500
CTNNB1	OMIM, HUMSAVAR	HGNC link	3p22.1	6	114550, 155255, 167000, PS156200, 114500, 132600
AKT1	OMIM	HGNC link	14q32.33	6	167000, 176920, 114480, 181500, 114500, PS158350
ODC1	OMIM	HGNC link	2p25.1	1	114500
AXIN2	OMIM	HGNC link	17q24.1	2	114500, 608615
RAD54B	OMIM	HGNC link	8q22.1	2	114500, 605027
PIK3CA	OMIM, HUMSAVAR	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
NRAS	OMIM	HGNC link	1p13.2	8	137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
DCC	OMIM	HGNC link	18q21.2	3	133239, PS157600, 114500
AURKA	OMIM	HGNC link	20q13.2	1	114500
DLC1	OMIM	HGNC link	8p22	1	114500
FLCN	OMIM	HGNC link	17p11.2	4	135150, 144700, 173600, 114500
TRIM28	ClinVar	HGNC link	19q13.43	1	114500
PLA2G2A	OMIM	HGNC link	1p36.13	1	114500
EP300	OMIM	HGNC link	22q13.2	2	114500, PS180849
FGFR3	OMIM	HGNC link	4p16.3	16	603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482
TP53	ClinVar, OMIM	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
CCND1	OMIM	HGNC link	11q13.3	3	193300, 254500, 114500
PTPN12	OMIM	HGNC link	7q11.23	1	114500
MCC	OMIM	HGNC link	5q22.2	1	114500
KAT5	ClinVar	HGNC link	11q13.1	1	114500
TLR2	OMIM	HGNC link	4q31.3	3	114500, 607948, 246300
BRAF	OMIM, HUMSAVAR	HGNC link	7q34	8	605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
TLR4	OMIM	HGNC link	9q33.1	2	114500, PS603075
APC	ClinVar, OMIM	HGNC link	5q22.2	6	114550, PS175100, 155255, 135290, 114500, 613659
PTPRJ	OMIM	HGNC link	11p11.2	1	114500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
5q22.2	2	MCC, APC
8p22	2	DLC1, PDGFRL

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
8p22	2	DLC1, PDGFRL
5q22	2	MCC, APC
19q13	2	BAX, TRIM28
11q13	2	CCND1, KAT5

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
19q1	2	BAX, TRIM28
17p1	2	FLCN, TP53
8p2	2	DLC1, PDGFRL
5q2	2	MCC, APC
11q1	2	CCND1, KAT5

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	2	NRAS, PLA2G2A
14q	2	MLH3, AKT1
5q	2	MCC, APC
19q	2	BAX, TRIM28
11q	2	CCND1, KAT5
7q	2	PTPN12, BRAF
8p	2	DLC1, PDGFRL
17p	2	FLCN, TP53

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	CCND1, PTPRJ, KAT5
14	2	MLH3, AKT1
17	3	FLCN, TP53, AXIN2
19	2	BAX, TRIM28
1	2	NRAS, PLA2G2A
3	2	CTNNB1, PIK3CA
5	2	MCC, APC
4	2	TLR2, FGFR3
7	2	PTPN12, BRAF
8	3	DLC1, RAD54B, PDGFRL

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
CTNNB1	YES	20	PTGS2, BIRC5, PPARD, CHGA, TCF7, CLDN2, CCND1, GLCE, CD44, GLI2, NRCAM, RB1, MMP14, JUN, SPP1, VIM, MYC, PLD1, MMP7, STARD7	1	CCND1
TRIM28	YES	2	E2F3, E2F4	0
EP300	YES	56	ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD51	1	CCND1
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	5	TP53, CCND1, BAX, AKT1, CTNNB1
KAT5	YES	4	ERCC1, IL2, HDC, GMPS	0
APC	YES	11	PTGS2, NOS2, KLF4, BIRC5, SPP1, DNMT1, AKT1, MYC, AMHR2, ODC1, SGK1	2	ODC1, AKT1
CDX2	NO	28	UGT2B15, GUCY2C, DSC2, IGFBP3, MUC17, TFF3, PTGS2, HEPH, ABCB1, SLC15A1, KLF4, ELMO3, SLC9A2, MEP1A, CDH17, UGT2B17, CDKN1A, VDR, MUC2, UGT1A8, AXIN2, LCT, FUT2, UGT1A10, REG4, ACAT2, APC, CFTR	2	APC, AXIN2
KLF4	NO	30	ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH5	3	CCND1, ODC1, TP53
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	4	CCND1, EP300, ODC1, TP53
BRCA1	NO	52	ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A	2	CCND1, EP300
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	5	FGFR3, CCND1, BAX, ODC1, TLR2
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	2	FGFR3, CCND1
SP4	NO	9	BIRC5, KDR, PDE6B, CCND1, ASS1, FGFR3, ERBB2, MAOB, YY1	2	FGFR3, CCND1
HIF1A	NO	80	RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A	3	CCND1, BAX, TLR2
MYCN	NO	44	MCM8, MCM7, HDAC2, TP53, BIRC5, IFNG, HLA-F, MCM3, LRRN3, BMI1, SKP2, MDM2, ABCB1, MCM2, DDB1, NES, CD44, HLA-C, HLA-G, CDKN1A, TP53INP1, HLA-B, NGFR, HLA-A, CIITA, MCM6, CTSD, ABCC1, LXN, DKK3, BAX, CDK6, HLA-E, NDRG1, TH, EFNB3, ID2, MCM5, MCM10, MYCL, TERT, NTRK1, MCM4, CDKN1B	2	BAX, TP53
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	3	CCND1, EP300, TP53
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	CCND1, TP53
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	3	CCND1, TP53, CTNNB1
FOS	NO	56	BATF3, BCL2L1, NPPA, FIGF, ACTA1, FGFBP1, DDIT3, CYP1A2, SMAD4, SLC10A2, MMP9, CCK, PGR, LRIG2, NQO1, FOS, EZR, MMP7, PTGS2, NGF, FAS, FMO4, SMAD7, STAR, CLU, SOX7, PLAU, SRR, NOS2, SPI1, PDHA1, MFI2, MMP1, TP53, OXTR, NPY, GSTP1, NTS, NFKB1, PCK2, CXCL8, CD40LG, CREM, PLAUR, IL1A, ERCC4, MMP3, NTF3, CASP9, CSTA, HSPH1, MYC, CCND1, SPRR3, NEFL, FOXA1	2	CCND1, TP53
NUPR1	NO	5	MSL1, BCL2L1, EP300, CDKN1A, TP53	2	EP300, TP53
PAX5	NO	20	XBP1, BAX, FCER2, LEF1, BLK, BCL2, MET, CCND1, RAG2, CDKN1A, TP53, PRDM1, RB1, CD79A, PRKCE, TIMP1, FHL2, MMP1, MYCN, CD19	3	CCND1, BAX, TP53
PPARG	NO	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	CCND1, TP53
ING4	NO	14	PTGS2, CDKN1A, CXCL8, BCL2, NGF, CCND1, BAX, SPP1, CASP3, TP53, SKP2, NTRK1, CDKN1B, ANGPT1	3	CCND1, BAX, TP53
ESR1	NO	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	3	CCND1, TP53, CTNNB1
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	2	CCND1, TP53
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	APC, TP53
ATM	NO	21	PVR, SP1, CDKN1A, BAX, MCL1, FOXM1, BCL2, FAS, TERF1, IGF1R, TNFRSF10B, SLC2A1, TP53, GADD45A, KLRK1, PMAIP1, DUSP1, CFLAR, VEGFA, HIPK2, MTF1	2	BAX, TP53
ABL1	NO	10	CDKN1A, CCND2, BCL2, BCL6, BAX, TP53, JUN, PIM1, FOXO3, CSF1	2	BAX, TP53
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	3	CCND1, TP53, AKT1
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	3	FGFR3, BAX, TP53
PML	NO	18	CDKN1A, IFNB1, FLT3, TNFSF10, EP300, UBA7, PML, BAX, TP53, HCK, CASP3, HBD, CCNT1, NR4A1, EGFR, EAF2, HIPK2, CCND1	4	CCND1, EP300, BAX, TP53
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	6	BAX, PLA2G2A, TP53, AKT1, CCND1, TLR2
LEF1	NO	32	AR, OCA2, PRL, NT5E, DLL1, CD1D, NCAM1, MMP7, CCL7, CEBPA, CCND1, CHGA, TCF3, CTNNB1, ALX4, BIRC5, RAG2, CLDN2, NRCAM, SPP1, MITF, IL13, SNAI2, EDA, IL4, DSG4, IL5, ELANE, ESR1, CTLA4, MYC, MYCBP	2	CCND1, CTNNB1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	6	BAX, PLA2G2A, TP53, AKT1, CCND1, TLR2
NELFCD	NO	3	CCND1, CDKN1A, CTNNB1	2	CCND1, CTNNB1
EZH2	NO	31	PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND1	3	APC, CCND1, TP53
AATF	NO	6	CDKN1A, BBC3, BAX, TP53, BAK1, MYC	2	BAX, TP53
ERCC2	NO	5	LAMTOR5, CDKN1A, BAX, TP53, BCL2	2	BAX, TP53
VHL	NO	18	CA9, STRA13, TCF4, TFRC, ANGPT2, CXCR4, CCND1, DAB2, KLF10, CDKN1C, CA12, TP53, NMU, HIF1A, SPARC, VEGFA, IGF1R, CDKN1B	2	CCND1, TP53
SOX6	NO	6	CDKN1A, CCND1, TP53, CDK4, CTNNB1, CCNA2	3	CCND1, TP53, CTNNB1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	BAX, TP53
NR3C1	NO	36	CALD1, PNRC1, TP53, RPS6KA3, BAX, SRF, SLC10A2, SCNN1A, BGLAP, TAT, RLN2, S100P, CYP19A1, MUC4, CCND1, NR1I2, ETS1, PPIG, BRCA1, ELK1, CSF1R, CDKN1A, UGT1A1, RLN1, SPP1, BAD, NFKB1, STAT1, COX1, NR3C1, CDK4, CDK6, CCND3, ATP1B1, ATF2, MAOA	3	CCND1, BAX, TP53
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	5	NRAS, CCND1, EP300, AKT1, CTNNB1
ING1	NO	7	CDKN1A, AFP, DGCR8, BAX, TP53, CASP3, PCNA	2	BAX, TP53
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	3	CCND1, AURKA, TP53
CREBBP	NO	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	2	EP300, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
BUB1B	YES	1	ZNF143	0
BAX	YES	25	ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A	1	TP53
CTNNB1	YES	8	AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT1	1	TP53
AKT1	YES	7	APC, STAT3, GLI1, AR, TP53, RELA, NFKB1	2	APC, TP53
ODC1	YES	11	WT1, SP1, ZNF148, KLF4, CREB1, MXD1, MLX, APC, MAX, MYC, MXD4	1	APC
AXIN2	YES	2	SOX4, CDX2	0
PIK3CA	YES	1	FOXO3	0
NRAS	YES	1	AR	0
DCC	YES	1	SOX9	0
AURKA	YES	4	MED1, OTX2, E2F1, E2F3	0
DLC1	YES	1	GATA3	0
PLA2G2A	YES	2	NFKB1, RELA	0
EP300	YES	7	CREBBP, AR, NUPR1, EGR1, PML, MYC, BRCA1	0
FGFR3	YES	5	SP1, SP3, SP4, STAT1, SHOX	0
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	1	TP53
CCND1	YES	62	POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX6	3	EP300, TP53, CTNNB1
KAT5	YES	1	CLOCK	0
TLR2	YES	4	SP1, NFKB1, HIF1A, RELA	0
TLR4	YES	4	ZNF160, SPI1, IRF3, IRF8	0
APC	YES	6	YY1, USF2, CEBPZ, EZH2, CDX2, USF1	0
PTGS2	NO	41	AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF1	3	APC, EP300, CTNNB1
DNMT1	NO	6	SP1, APC, STAT3, NPM1, TP53, EP300	3	APC, EP300, TP53
ABCB1	NO	30	NFYA, EAPP, TP53, TCF7L2, SP1, TCF4, NFKB1, NR1I2, E2F1, HIPK2, SIRT1, WT1, HSF1, HDAC1, NFYC, JUN, MBD1, RELA, EP300, ETS1, NFYB, UHRF1, EGR1, PITX2, YBX1, CEBPB, ZNRD1, HIF1A, CDX2, MYCN	2	EP300, TP53
RELA	NO	18	SP1, ETV3, TNFAIP3, HSF1, BCL3, NR1H4, AR, TP53, NR1I2, HOXA9, ATF2, NFKBIA, PGR, PARP1, HDAC9, EP300, APEX1, FHL2	2	EP300, TP53
BRCA1	NO	33	WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA1	2	EP300, TP53
TBXAS1	NO	3	EP300, ETS1, TP53	2	EP300, TP53
TRIM22	NO	4	IRF1, EP300, CREBBP, TP53	2	EP300, TP53
BGLAP	NO	11	NR3C1, VDR, ATF4, ATF6, SMAD4, GTF2F1, SMAD3, TP53, EP300, MSX2, RARG	2	EP300, TP53
MDM2	NO	23	TFAP4, TP53, NFATC2, JUND, DNMT3A, SP1, ELF4, ZBTB2, SKI, MLLT10, E2F1, FOSL2, ELL, MLLT3, ETS2, EP300, ETS1, FUS, TSG101, ESR1, NR4A1, TP73, MYCN	2	EP300, TP53
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	EP300, TP53
IGFBP3	NO	12	SP1, DLX5, HOXC6, VDR, HDAC1, FLI1, MECP2, TP53, CDX2, SP3, DNMT3A, EP300	2	EP300, TP53
VEGFA	NO	53	ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F3	2	EP300, TP53
PML	NO	7	STAT2, IRF9, TP53, ARID3A, EP300, PML, STAT1	2	EP300, TP53
NFKB1	NO	30	AR, BCL3, TNFAIP3, BTF3, TP53, NFKBIA, ZNF382, HDAC9, FOS, SP1, BCL6, EGR1, NFKB1, HOXA9, TAL1, NR1I2, SRSF1, LYL1, ETV3, HSF1, RELA, PARP1, PIR, EP300, FHL2, NR1H4, NR3C1, RBPJ, APEX1, ZFP36	2	EP300, TP53
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	4	APC, EP300, TP53, CTNNB1
TP73	NO	9	KAT2B, EGR1, YY1, TP53, JUN, E2F1, EP300, MYC, SIRT1	2	EP300, TP53
SPP1	NO	23	POU2F1, ETS2, TFCP2, TBX21, POU5F1, SP1, ETV4, CEBPA, FOXD3, ETS1, CTNNB1, HTATIP2, ESRRA, APC, LEF1, VDR, HDAC1, ERG, JUN, ING4, EP300, POU2F2, NR3C1	3	APC, EP300, CTNNB1
BIRC5	NO	25	ILF3, E2F4, TP53, TCF7L2, SP1, TCF4, NFKB1, KLF4, DNMT1, CTNNB1, FOXO3, APC, LEF1, HDAC1, RELA, EP300, E2F1, STAT3, SP4, EHMT2, RB1, SP3, TP73, KLF5, MYCN	4	APC, EP300, TP53, CTNNB1
RB1	NO	19	KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX5	2	TP53, CTNNB1
GLI2	NO	3	SMAD3, TP53, CTNNB1	2	TP53, CTNNB1
CCNB2	NO	2	EP300, TP53	2	EP300, TP53
E2F3	NO	6	KLF5, TP53, BRD7, RB1, TRIM28, HIF1A	2	TRIM28, TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BUB1B	CTNNB1	No	12	KAT2B, APC, TRIM33, HDAC1, XPO1, BTRC, NEK2, CDC27, PARP1, MIS12, PLK1, CCNA2
BUB1B	AKT1	No	4	KAT2B, HSPB1, TUBB, MDM2
BUB1B	AXIN2	No	2	APC, CDC20
BUB1B	RAD54B	No	3	MDM2, SUMO1, CDC23
BUB1B	PIK3CA	No	2	HDAC1, BUB1
BUB1B	AURKA	No	17	AURKB, NUF2, MDM2, PRKCSH, PTTG1, PLK3, PSMB5, NDC80, PLK1, TUBB, BTRC, XPO1, EEF2, PSMA6, SNW1, CDC20, TP73
BUB1B	FLCN	No	1	BTRC
BUB1B	TRIM28	No	7	MDM2, UBE2C, HDAC1, CCT2, ZWINT, PARP1, MIS12
BUB1B	EP300	No	14	KAT2B, ANAPC7, ANAPC2, MDM2, AURKB, HDAC1, CDC16, BTRC, EEF2, PARP1, TP73, CDC20, SNW1, CCNA2
BUB1B	TP53	No	26	KAT2B, MDM2, BTRC, TUBB, SNW1, AURKB, CCNA2, EEF2, SUMO1, PSMD6, RAE1, HSPB1, DAXX, HDAC1, CCT2, MAD2L1BP, BAG2, PARP1, UBR5, BRCA2, PTTG1, PLK3, PLK1, ZWINT, TP73, FZR1
BUB1B	CCND1	No	6	KAT2B, HDAC1, PSMA6, BTRC, XPO1, TP73
BUB1B	PTPN12	No	2	UGP2, GANAB
BUB1B	MCC	No	1	NEK2
BUB1B	KAT5	No	5	TP73, HDAC1, MAD2L1BP, MDM2, SUMO1
BUB1B	TLR2	No	1	CD14
BUB1B	APC	Yes	9	PPP2R5A, APC, BUB1B, MAD2L1, BUB3, BTRC, XPO1, BUB1, AP2B1
MLH3	CTNNB1	No	1	AR
MLH3	AKT1	No	1	AR
MLH3	DCC	No	1	AR
MLH3	TRIM28	No	1	MYC
MLH3	EP300	No	2	MYC, AR
MLH3	TP53	No	1	MYC
MLH3	CCND1	No	1	AR
MLH3	KAT5	No	2	MYC, AR
BAX	CTNNB1	No	4	CASP3, CRYAB, HDAC6, UHRF2
BAX	AKT1	No	8	BCL2L1, LRRK2, VCP, PSMC5, HSPA4, XIAP, BAD, SNCA
BAX	PIK3CA	No	1	PCBP1
BAX	DCC	No	2	CASP3, CASP9
BAX	AURKA	No	5	HSPD1, BCL2L11, HDAC6, NIN, TP53
BAX	FLCN	No	1	BAG3
BAX	TRIM28	No	3	YWHAQ, MEPCE, TP53
BAX	EP300	No	5	PKM, YY1, XRCC6, TP53, HDAC6
BAX	FGFR3	No	1	HSPA4
BAX	TP53	Yes	21	SERPINH1, BCL2L1, BAX, CASP8, VCP, PARK7, PCBP1, YY1, HSPA4, CRYAB, TP53, MCL1, UHRF2, BAK1, BCL2, ERCC6, NIN, PSMC3, BCL2L2, PSMC5, XRCC6
BAX	CCND1	No	2	CRYAB, UHRF2
BAX	MCC	No	2	VDAC1, VCP
BAX	KAT5	No	2	HDAC6, TP53
BAX	BRAF	No	3	BAD, YWHAQ, YWHAB
BAX	TLR4	No	1	HSPA4
BAX	APC	No	1	YWHAQ
CTNNB1	AKT1	Yes	43	KAT2B, DDX5, HSP90AB1, AR, SMAD4, EZH2, CREB1, EGFR, JADE1, TRAF4, CTBP1, CHUK, IQGAP1, GSK3B, UCHL1, SMAD7, USP4, SMAD3, APP, FOXO4, BRCA1, PYGO2, SIRT1, NOTCH1, GSK3A, SFN, MAPK9, MAPK8, SMAD2, SLC9A3R1, NR4A1, AKT1, EP300, FOXO3, FANCA, HSPA8, ILK, CREBBP, IKBKB, PTEN, YWHAZ, ESR1, PHB2
CTNNB1	AXIN2	Yes	8	APC, GSK3A, SMAD7, APC2, AXIN1, NR4A1, GSK3B, FBXW11
CTNNB1	RAD54B	No	1	FUS
CTNNB1	PIK3CA	No	10	DDX5, AKT1, HDAC1, NOTCH1, SMAD2, PIK3R1, SMAD3, ESR1, NTRK1, CBL
CTNNB1	NRAS	No	1	ELAVL1
CTNNB1	DCC	No	4	CASP3, SIAH1, AR, EZR
CTNNB1	AURKA	Yes	31	DDX5, LATS2, PARK2, XPO1, CTNND1, HSP90AB1, HNRNPA1, EZR, CHUK, CEP128, GSK3B, PML, HDAC6, DHX9, DDB1, HNRNPA2B1, MAPRE1, APP, BRCA1, IKBKB, TFAP2A, HSPA8, NFKB1, AMER1, RPLP2, SKP1, FUS, AURKA, BTRC, PLK1, USP9X
CTNNB1	DLC1	No	6	CUL1, CUL4A, CAV1, DDB1, AKT1, CUL3
CTNNB1	FLCN	No	3	BTRC, FBXW11, APP
CTNNB1	TRIM28	No	30	WHSC1, HUWE1, CUL1, OBSL1, EZH2, POU5F1, COPS5, LMNA, TADA2A, SIRT1, SMURF1, SFN, HDAC1, NR4A1, RUVBL2, PARP1, NOTCH1, CDK2, UBE2D1, EMD, CREBBP, AURKA, SNRPD1, CCDC8, ILK, HIF1A, SMARCA4, NTRK1, MIS12, CUL3
CTNNB1	PLA2G2A	No	2	UCHL1, USP4
CTNNB1	EP300	Yes	61	KAT2B, AR, AKT1, BCL6, HDAC6, DDX5, SMAD4, PARP1, TCF7L2, ATF2, CREB1, PIN1, ZBTB33, ASH2L, CCNA2, PTGS2, CITED1, CARM1, TCF4, NFKB1, KLF5, SMAD7, DDB1, RBBP5, SMAD3, CHUK, FOXO3, ESR1, YWHAZ, SP1, PRKCA, LEF1, EPAS1, HDAC1, MAPK8, SMAD2, CDH1, SATB1, NR4A1, TFAP2A, RUVBL2, LRRFIP1, BCL3, EP300, BRCA1, FHL2, NOTCH1, CDK2, UBE2D1, CREBBP, BTRC, CTBP1, PIK3R1, NUP98, SIRT1, TADA3, AHR, RXRA, PPARG, MCM2, HIF1A
CTNNB1	FGFR3	No	3	HSPA8, HSPA1B, HSP90AB1
CTNNB1	TP53	No	95	DDX5, TRRAP, PIN1, HTT, RBBP5, FOXO3, KMT2A, ELAVL1, NR4A1, ABL1, UBE2B, EP400, RPLP2, HSPA1B, SKP1, SERBP1, PLK1, ESR1, KAT2B, HNRNPA1, HERC5, HSP90AB1, ASH2L, PTGS2, MAPK8, CARM1, DDB1, CCNA2, LMNA, SMURF1, SFN, HERC2, MAPK9, AURKA, HNRNPM, KLF5, HIF1A, HNRNPK, BTRC, CUL4A, ZBTB33, CHUK, IQGAP1, BCL6, TCF4, UCHL1, TUBA1A, CREB1, HNRNPA2B1, AXIN1, SMAD3, BRCA1, FBXW11, OBSL1, HDAC1, SMAD2, IKBKB, TFAP2A, PTEN, EP300, SMARCA4, MOV10, CDK2, MEN1, CCDC8, SIRT1, TADA3, HNF4A, KAT2A, FOXB1, CRYAB, ZIC3, RB1CC1, DVL2, RYK, CTBP1, MUC1, CEP128, PML, SMAD7, COPS5, TADA2A, YWHAZ, SP1, CHD8, SMARCA5, TOP2A, PARP1, GSK3B, HSPA8, CREBBP, HUWE1, NLK, UHRF2, RANBP2
CTNNB1	CCND1	No	22	KAT2B, AR, CDK2, HERC5, CUL1, XPO1, BTRC, NXF1, SP1, EP300, MCM2, BRCA1, CRYAB, HDAC1, ATF2, ELAVL1, GSK3B, HSPA8, CDK6, SKP1, UHRF2, ESR1
CTNNB1	PTPN12	No	3	NTRK1, EGFR, APP
CTNNB1	MCC	No	6	ERBB2IP, CCNA1, STRN3, NEK2, EZR, APP
CTNNB1	KAT5	No	28	AR, BCL3, HINT1, TRRAP, ZBTB33, APP, RUVBL1, NFKB1, PML, HDAC6, MAPRE1, CREB1, HDAC7, LMNA, BRCA1, SIRT1, HDAC1, NOTCH1, ATF2, RUVBL2, EP300, EP400, CREBBP, CCDC8, JADE1, ESR1, PPARG, CUL3
CTNNB1	TLR2	No	2	CREBBP, EGFR
CTNNB1	BRAF	No	6	IQGAP1, HSPA8, AKT1, HSP90AB1, SFN, YWHAZ
CTNNB1	TLR4	No	2	SMAD3, HSPA8
CTNNB1	APC	Yes	32	LATS2, DLGAP1, STRN3, XPO1, SIAH1, BTRC, CTBP1, MUC1, ERBB2IP, NHSL1, CEP128, MAPRE1, AXIN1, COPS5, CTNNA1, NUP153, FBXW11, APC, SFN, APC2, JUP, AXIN2, TFAP2A, AP2M1, EPAS1, GSK3B, AMER1, CREBBP, DVL2, HNRNPM, NUP98, RANBP2
CTNNB1	PTPRJ	Yes	4	LGALS9, PTPRJ, CTNND1, EGFR
AKT1	AXIN2	No	5	NR4A1, GSK3A, GSK3B, SMAD7, CTNNB1
AKT1	RAD54B	No	1	MDM2
AKT1	PIK3CA	Yes	12	IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
AKT1	NRAS	No	2	DNAJB1, RAF1
AKT1	DCC	No	2	AR, APPL1
AKT1	AURKA	No	28	DDX5, MDM2, TUBB, HSP90AB1, HSPA5, IKBKG, THRSP, APP, NPM1, NCOR2, CHUK, CTNNB1, YBX1, PPP1CC, S100A14, HSPA9, PPP1CB, IKBKB, HSP90AA1, RQCD1, MTA3, GSK3B, BRCA1, HSPA8, CSNK2A1, CDC37, PPP1CA, EPSTI1
AKT1	DLC1	Yes	1	AKT1
AKT1	FLCN	No	1	APP
AKT1	TRIM28	No	22	MDM2, EZH2, VIM, NPM1, ARRB2, HDAC3, SKI, MAPKAPK2, DNMT1, PPP1CC, SIRT1, SIRT6, SETDB1, PPP1CB, NFE2L2, NR4A1, SMARCC1, NOTCH1, ILK, CREBBP, PPP1CA, SFN
AKT1	PLA2G2A	No	4	UCHL1, VIM, USP4, USP8
AKT1	EP300	Yes	53	KAT2B, AR, MDM2, ACTA1, GATA2, SNAI1, TNK2, SMAD4, FHL1, MAP3K5, CREB1, HSPA5, CTBP1, SKP2, COMMD1, MAPK8, MAPT, BRCA1, SMAD7, KAT6A, NPM1, NCOR2, HDAC3, SMAD3, CHUK, FOXO1, CLTC, MAPK14, YWHAZ, CDKN1A, CTNNB1, GAPDH, PRKDC, HIST2H2BE, RARA, RPS6KB1, NR4A1, SMAD2, AKT1, TCL1A, EP300, FOXO3, NOTCH1, CREBBP, PRKCB, ACTB, YBX1, DDX5, PPP2CA, SIRT1, ESR1, GATA1, IRF3
AKT1	FGFR3	No	5	HSPA4, HSPA8, CDC37, HSP90AA1, HSP90AB1
AKT1	TP53	No	74	KAT2B, BCL2L1, PIAS1, ZHX1, VCP, PSMC5, YWHAE, DDX5, SRC, CREB1, VIM, APOH, HSP90AB1, HSPA5, CTBP1, STUB1, IQGAP1, TNK2, MDM2, TUBB, MAPK8, YBX1, GSK3B, MDH1, BRCA1, SMAD7, STK4, SKI, DNAJB1, SMAD3, DAB2IP, TBC1D4, DNMT1, MAPK14, APPL1, ALYREF, YWHAZ, HSPA9, SFN, PIAS2, GAPDH, PRKDC, SMARCB1, MAPK9, CLTC, SMAD2, IKBKB, MUL1, NR4A1, HSP90AA1, PTEN, NPM1, PPP2R1A, PPP3CA, EP300, FOXO3, KAT6A, SMARCC1, CREBBP, PPP1CC, HSPA8, SNAI1, CSNK2A1, HSPA4, ACTB, MTOR, CDKN1A, PPP1CA, CHUK, HSPB1, SIRT1, ESR1, TPM4, UCHL1
AKT1	CCND1	No	14	KAT2B, CDKN1A, HSPA8, TSC2, EP300, AR, CDKN1C, HDAC3, PPP1CB, ESR1, BRCA1, GSK3B, PPP1CC, CDKN1B
AKT1	PTPN12	No	2	EGFR, APP
AKT1	MCC	No	4	PPP2R1A, CLTC, APP, VCP
AKT1	KAT5	No	23	AR, MDM2, APP, TRIB3, LDHA, ACTA1, CREB1, HDAC3, DNMT1, BRCA1, SIRT1, TNK2, GAPDH, PRKDC, HSP90AA1, ACTB, EP300, NOTCH1, CREBBP, GET4, YWHAG, ESR1, JADE1
AKT1	TLR2	No	4	CREBBP, IRAK1, EGFR, IRF3
AKT1	BRAF	Yes	17	CCDC88A, HSPA9, HSPA8, HSP90AB1, YWHAE, BRAF, CDC37, IQGAP1, HSP90AA1, RAF1, YWHAG, NEDD4, SFN, HSPA5, AKT1, BAD, YWHAZ
AKT1	TLR4	No	9	HSPA8, PRKCZ, TBK1, HSPA4, TRAF6, SMAD3, SRC, IRAK1, STUB1
AKT1	APC	No	14	AGR3, MARK2, SFN, CTBP1, CREBBP, IL24, CASC3, CTNNB1, SETDB1, HSPA5, GSK3B, CSNK2A1, TFF1, ST14
AKT1	PTPRJ	No	5	EPSTI1, PLCG1, EGFR, CASC3, CTNNB1
ODC1	RAD54B	No	1	GORASP2
ODC1	EP300	No	1	KAT5
ODC1	TP53	No	3	KAT5, TK1, CSNK2B
ODC1	KAT5	Yes	2	KAT5, ODC1
ODC1	APC	No	1	CSNK2B
AXIN2	AURKA	No	3	CDC20, GSK3B, CTNNB1
AXIN2	FLCN	No	1	FBXW11
AXIN2	TRIM28	No	1	NR4A1
AXIN2	EP300	No	4	NR4A1, SMAD7, CTNNB1, CDC20
AXIN2	TP53	No	5	NR4A1, AXIN1, GSK3B, SMAD7, FBXW11
AXIN2	CCND1	No	1	GSK3B
AXIN2	APC	Yes	6	APC, AXIN1, FBXW11, CTNNB1, GSK3B, RNF146
AXIN2	PTPRJ	No	1	CTNNB1
RAD54B	AURKA	No	4	FUS, UBE2I, PSMA1, MDM2
RAD54B	TRIM28	No	2	UBE2I, MDM2
RAD54B	EP300	No	5	UBE2I, PRKAA1, MDM2, MDM4, COPS6
RAD54B	TP53	No	9	SUMO1, CSNK1E, HECW2, MDM2, MDM4, PLCG2, UBE2I, WRN, RAD51
RAD54B	MCC	No	1	CSNK1E
RAD54B	KAT5	No	4	UBE2I, GMCL1, MDM2, SUMO1
RAD54B	APC	No	1	CSNK1E
PIK3CA	NRAS	No	1	RPS20
PIK3CA	DCC	No	1	APPL1
PIK3CA	AURKA	No	7	NEDD9, DDX5, BEX2, FTL, IRS4, PSMC3IP, THRSP
PIK3CA	DLC1	No	1	AKT1
PIK3CA	TRIM28	No	4	NTRK1, HDAC1, NOTCH1, STAT1
PIK3CA	EP300	No	12	NOTCH1, AKT1, HDAC1, DDX5, SMAD2, ATR, PIK3R1, SMAD3, ESR1, GRB2, WDR5, STAT1
PIK3CA	FGFR3	No	1	GRB2
PIK3CA	TP53	No	16	UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
PIK3CA	CCND1	No	3	HDAC1, UBTF, ESR1
PIK3CA	PTPN12	No	4	NEDD9, NTRK1, GRB2, GSN
PIK3CA	KAT5	No	4	NOTCH1, HDAC1, UBTF, ESR1
PIK3CA	BRAF	No	3	HRAS, YWHAH, AKT1
PIK3CA	TLR4	No	1	SMAD3
PIK3CA	APC	No	1	IL24
PIK3CA	PTPRJ	No	1	GRB2
NRAS	AURKA	No	1	EEF1A1
NRAS	EP300	No	1	EEF1A1
NRAS	TP53	No	4	EEF1A1, ELAVL1, DNAJB1, VAT1
NRAS	CCND1	No	1	ELAVL1
NRAS	KAT5	No	1	RGL2
NRAS	BRAF	No	1	RAF1
DCC	AURKA	No	6	RPS10, RPL23, BARD1, RPS4X, RPL38, EZR
DCC	EP300	No	2	AR, MAPK1
DCC	TP53	No	16	RPL10A, RPS6, RPL5, MAPK3, RPS24, BARD1, MAPK1, PTK2, RPS4X, RPL28, RPS13, RPS10, RPL13, APPL1, RPL23, EIF2S2
DCC	CCND1	No	2	AR, MAPK1
DCC	MCC	No	1	EZR
DCC	KAT5	No	3	AR, BARD1, SIAH2
DCC	BRAF	No	2	MAPK1, MAPK3
DCC	APC	No	2	SIAH1, PTK2
AURKA	DLC1	No	1	DDB1
AURKA	FLCN	No	2	BTRC, APP
AURKA	TRIM28	Yes	16	VHL, HIST3H3, MDM2, PPP1CB, AURKA, CDKN2A, UBE2N, UBE2L3, TRIM28, PPP1CA, TP53, LARP7, NPM1, CBX3, UBE2I, PPP1CC
AURKA	PLA2G2A	No	2	USP2, USP47
AURKA	EP300	No	34	DDX5, HIST3H3, MDM2, ILF3, TFAP2A, RPL27, NPM1, AURKB, SNW1, CHUK, GTF3C2, TP73, KLF4, REL, HDAC6, DDB1, NCOR2, CALCOCO1, CTNNB1, BRCA1, CDC20, ILF2, VHL, ASCC1, TP53, EEF2, NFKB1, EEF1A1, BTRC, YBX1, SIRT2, HNRNPU, HSPA5, UBE2I
AURKA	FGFR3	No	5	HSPA8, CDC37, SRPK2, HSP90AA1, HSP90AB1
AURKA	TP53	Yes	91	DDX5, FTH1, TP53, RPL27, RPS19, SIRT7, PPP1CC, OTUB1, UBE2N, TRIM28, RPL11, RPLP2, SKP1, PTTG1, RPS14, BTRC, PLK1, HNRNPA1, RPS4X, HSP90AB1, SNW1, SETD2, HSPA5, TUBG1, NIN, LRPPRC, DDB1, HSPA2, HSPA9, RPS16, RPLP0, HSP90AA1, IRS4, RPS27, PRRC2C, HDAC2, RPS3A, NFKBIA, GADD45A, EEF1A1, TP73, RPL30, HSPA1A, MFAP4, DGCR14, LYZ, TUBA1C, CDKN2A, CHUK, TUBB4B, EEF2, RPL23, HNRNPA2B1, PCMT1, CEP55, VHL, PPP1CA, IKBKB, RPS3, DCAF7, BRCA1, RPL12, PDCD6, CSNK2A1, RPS10, HNRNPU, MDM2, AURKA, TFAP2A, TAF9, AURKB, IGF2BP1, CEP128, PML, NPM1, CELA2B, NCL, IGF2BP3, BARD1, ITPKC, SRPK1, MRPL24, GSK3B, UBE2I, HSPA8, MRPS22, UBB, PLK3, YBX1, TUBB, TCEAL4
AURKA	CCND1	No	14	CDKN2A, HSPA8, SKP1, TP73, USP2, HDAC2, PPP1CB, BTRC, XPO1, CDH13, PSMA6, BRCA1, GSK3B, PPP1CC
AURKA	PTPN12	No	2	NEDD9, APP
AURKA	MCC	No	6	VHL, IARS, TARS, EZR, EPRS, APP
AURKA	KAT5	No	18	VHL, UBE2I, HIST3H3, MDM2, TP73, HDAC6, KLF4, BARD1, TP53, PML, MAPRE1, HSP90AA1, ANGPTL4, CDKN2A, RPL30, NFKB1, BRCA1, APP
AURKA	BRAF	No	7	HSPA1A, HSPA8, CDC37, HSPA9, HSP90AA1, HSP90AB1, HSPA5
AURKA	TLR4	No	1	HSPA8
AURKA	APC	No	17	AMER1, DKK3, LATS2, FBXO30, CEP128, GSK3B, CSNK2A1, NAT2, BTRC, TFAP2A, PDLIM2, XPO1, CTNNB1, MAPRE1, HSPA5, RPS27, MAPRE2
AURKA	PTPRJ	No	4	LYPD3, EPSTI1, CTNND1, CTNNB1
DLC1	TRIM28	No	3	CUL1, CUL2, CUL3
DLC1	EP300	No	2	DDB1, AKT1
DLC1	TP53	No	2	DDB1, CUL4A
DLC1	CCND1	No	1	CUL1
DLC1	KAT5	No	1	CUL3
DLC1	BRAF	No	1	AKT1
FLCN	TRIM28	No	1	TP53BP1
FLCN	EP300	No	3	BTRC, TP53BP1, GAG-POL
FLCN	TP53	No	4	BTRC, MAP1LC3B, FBXW11, TP53BP1
FLCN	CCND1	No	1	BTRC
FLCN	PTPN12	No	1	APP
FLCN	MCC	No	1	APP
FLCN	KAT5	No	1	APP
FLCN	APC	No	2	BTRC, FBXW11
TRIM28	PLA2G2A	No	1	VIM
TRIM28	EP300	No	39	HIST3H3, CDK2, MDM2, TP53, MYB, IRF7, BMI1, STAT6, HIST1H3A, NCOR1, KDM1A, NPM1, SERTAD1, HDAC3, ZNF350, E2F1, SIRT1, VHL, SENP3, HDAC1, NOTCH1, MAGED1, NR4A1, RUVBL2, PARP1, SUMO2, UBE2I, STAT1, STAT3, UBE2D1, NR3C1, IRF1, TP53BP1, CEBPB, UBC, MYC, HHV8GK18_GP81, CREBBP, HIF1A
TRIM28	TP53	Yes	73	ATM, WWOX, RNF2, CDK2, MDM2, AURKA, TOPORS, SMURF1, ERBB4, LYN, VIM, CCDC8, TRIM24, BMI1, STAT6, CDKN2A, NCOR1, KDM1A, MAGEA2, CCT5, CCT3, SFN, RPA1, CCT8, COPS5, RPA2, CCT7, DNMT1, HDAC5, CHD3, SIRT1, VHL, NDN, RRP1B, LMNA, SENP3, SIN3A, HDAC1, OBSL1, CCT2, ZNF420, SET, TRIM28, MTA2, NPM1, PARP1, CHEK2, H2AFX, TADA2A, BRCC3, SMARCC1, TP53BP1, PPP1CC, UHRF1, NR3C1, PPP4C, UBE2I, SKI, HUWE1, UBE2N, ENAH, ZWINT, PPP1CA, TP53, CUL7, SMARCA4, UBC, NR4A1, MYC, IRF7, HHV8GK18_GP81, CREBBP, HIF1A
TRIM28	CCND1	No	9	STAT3, CDK2, HDAC1, PPP1CB, CUL1, HDAC3, CDKN2A, PPP1CC, CUL7
TRIM28	PTPN12	No	1	NTRK1
TRIM28	MCC	No	2	VHL, CBX5
TRIM28	KAT5	No	29	ATM, HIST3H3, MDM2, TP53, MYB, HIST1H3A, BMI1, HDAC3, DNMT1, LMNA, E2F1, SIRT1, VHL, CCT7, HDAC1, NOTCH1, RUVBL2, H2AFX, UBE2I, CDKN2A, STAT3, UHRF1, NR3C1, TRIM23, CREBBP, CCDC8, MYC, HHV8GK18_GP81, CUL3
TRIM28	TLR2	No	1	CREBBP
TRIM28	BRAF	No	3	YWHAQ, ARAF, SFN
TRIM28	TLR4	No	2	SERTAD1, PPP4C
TRIM28	APC	No	10	RPA2, NUP214, CREBBP, HTRA2, CEP250, COPS5, SFN, UBC, SETDB1, YWHAQ
TRIM28	PTPRJ	No	1	FBXO6
PLA2G2A	EP300	No	1	BAG6
PLA2G2A	TP53	No	3	UCHL1, VIM, USP7
PLA2G2A	CCND1	No	1	USP2
PLA2G2A	PTPN12	No	1	BAG6
PLA2G2A	KAT5	No	2	SENP6, USP7
EP300	FGFR3	No	2	GTF3C1, GRB2
EP300	TP53	Yes	145	DDX5, PCNA, TDG, ETS2, RPL27, DDB1, PIN1, PPP1R13L, FOXO3, NCOA3, IRF7, RBBP5, PSMD10, MAPK14, SOX4, TNK2, NFATC1, NCOA1, TP53, RELA, CCNA2, PRDM2, FBXW8, TP63, YY1, ANXA2, ESR1, ZBTB16, TSG101, KAT2B, NFYA, BCL6, ZBTB33, MAP9, TWIST1, EWSR1, BMI1, ASH2L, KAT5, ERCC8, PTGS2, CLTC, PRMT1, ZNF148, EGR1, PRKCD, CRTC2, SETD1A, GPS2, KAT6A, NCOR1, NCOA2, PPARGC1A, SENP3, GAPDH, RPS26, ACTB, WDR82, ING4, ETS1, TAF1B, BRD7, SMAD1, TP73, HIF1A, GTF3C3, CXXC1, MDC1, BTRC, HSPA5, STAT6, CHUK, KDM1A, BANP, EEF2, RUNX2, TCF4, KLF5, CREB1, MTA1, SMAD3, MYBBP1A, APEX1, BRCA1, HIPK2, SIRT1, VHL, ACTA2, HDAC1, PRKDC, RB1, SMAD2, TFAP2A, SNW1, ZBTB8A, EP300, EEF1A1, TP53BP1, CDK2, WDR5, XRCC6, HNRNPU, TADA3, COPS2, MDM4, CDK1, MDM2, TBP, TP53BP2, HCVGP1, SNAI1, ZBTB17, VPR, NABP2, TAT, CTBP1, AURKB, ATR, SMAD7, NPM1, PPP2R5C, YWHAZ, SP1, CDKN1A, VDR, PLAGL1, MAPK8, ING2, UBC, PARP1, CARM1, MSH6, MYC, NFYB, NR3C1, CREBBP, MAPK1, YBX1, PPP1R13B, ING5, SP3, NR4A1, UBE2I, HHV8GK18_GP81, ING1
EP300	CCND1	Yes	27	KAT2B, AR, PCNA, CDK1, BTRC, SP1, CCND1, NCOA3, HDAC3, BRCA1, CDKN1A, THRA, HDAC1, ATF2, NCOA1, RELA, EP300, FBXW8, STAT3, NEUROD1, CDK2, MAPK1, MCM3, RB1, ESR1, TP73, MCM2
EP300	PTPN12	No	4	SMAD5, GRB2, DEK, BAG6
EP300	MCC	No	4	VHL, CLTC, KRT18, DYNC1I1
EP300	KAT5	Yes	62	NBN, ZBTB7B, HIST4H4, RELA, MDM2, HDAC6, TAT, KAT5, AR, TP53, HIST1H3A, MYB, HIST2H3C, HIST3H3, ZBTB33, PCNA, BMI1, HIST1H4A, TNK2, TP73, EP300, KLF4, ACTA1, CREB1, GAPDH, HDAC3, CBX8, BRCA1, MRE11A, SIRT1, SRCAP, VHL, GOLGA2, ESR1, ESR2, FOXP3, HDAC1, PRKDC, NOTCH1, ATF2, ACTB, RUVBL2, MYOD1, BCL3, ZBTB8A, NFKB1, UBE2I, CDK1, E2F1, MED23, STAT3, NR3C1, MORF4L1, HHV8GK18_GP81, CREBBP, ZBTB49, RB1, ZEB1, MAX, RAD50, MYC, PPARG
EP300	TLR2	No	2	CREBBP, IRF3
EP300	BRAF	No	7	TERF1, MAPK1, PAK2, AKT1, RPS6KB2, HSPA5, YWHAZ
EP300	TLR4	No	3	SERTAD1, UBQLN1, SMAD3
EP300	APC	No	15	GOLGA2, CTNNB1, CREBBP, SAV1, TFAP2A, UBC, BTRC, NUP98, MCM3AP, PCNA, EPAS1, ING5, HSPA5, CTBP1, PPP1R13B
EP300	PTPRJ	No	2	GRB2, CTNNB1
FGFR3	TP53	No	9	HNRNPL, HSPA8, HSPA1B, HSPA4, ATF3, RPL8, SOCS1, HSP90AA1, HSP90AB1
FGFR3	CCND1	No	1	HSPA8
FGFR3	PTPN12	No	1	GRB2
FGFR3	KAT5	No	2	ATF3, HSP90AA1
FGFR3	BRAF	No	4	CDC37, HSPA8, HSP90AA1, HSP90AB1
FGFR3	TLR4	No	2	HSPA4, HSPA8
FGFR3	PTPRJ	No	1	GRB2
TP53	CCND1	No	39	KAT2B, CDK1, PCNA, HERC5, MAPK1, CRYAB, TAF1, BTRC, RFC1, SLC25A5, CDKN2A, BRINP1, SP1, GSK3B, WDR77, NCOA3, RB1, THRB, BRCA1, CDKN1A, HDAC1, PRMT5, ELAVL1, RBX1, NCOA1, FBXO4, RANBP9, EP300, PPP1CC, FBXW8, HSPA8, CDK2, SKP1, HDAC2, UHRF2, ESR1, TP73, RELA, CUL7
TP53	PTPN12	No	1	GSN
TP53	MCC	No	8	VHL, CLTC, PSME3, CSNK1E, VCP, TPM3, CSNK1D, PPP2R1A
TP53	KAT5	Yes	63	ATM, SAT1, RELA, MDM2, H2AFX, SSX2IP, KAT5, ATF3, RRM2, TRRAP, CREB1, CDC42, RCHY1, TAT, TP73, PCNA, ZBTB33, HSP90AA1, HHV8GK18_GP81, TNK2, SUMO1, CCDC106, PDCD5, RPL30, BRD8, DLEU1, DNMT1, LMNA, BRCA1, ACTL6A, SIRT1, VHL, CCT7, GAPDH, PRKDC, HDAC1, BARD1, USP7, MAD2L1BP, TP53, NINL, MAP3K1, ZNF24, TRIM27, BMI1, ZBTB8A, EP300, UBE2I, CDK1, CDKN2A, EP400, UHRF1, NR3C1, HABP4, ARIH2, CREBBP, ACTB, CCDC8, RB1, ESR1, MYC, FAM173A, PML
TP53	TLR2	No	1	CREBBP
TP53	BRAF	No	14	HSPA9, HSPA8, HSP90AB1, PHKB, MAPK1, HRAS, IQGAP1, MAPK3, HSPA1A, HSP90AA1, YWHAE, SFN, HSPA5, YWHAZ
TP53	TLR4	No	6	HSPA8, PPP4C, HSPA4, SMAD3, SRC, STUB1
TP53	APC	No	37	CSNK1E, TFAP2A, BTRC, HSPA5, CTBP1, MUC1, CEP128, CSNK2B, PTK2, AXIN1, COPS5, RPA2, RPS27, SFN, FBXW11, ING5, HECTD1, ANXA7, RPGRIP1L, CSNK1A1, GIGYF2, TAF1, PCNA, RANBP9, GSK3B, CSNK2A1, CREBBP, MYO6, SENP1, LAMA4, TUBA4A, DVL2, HNRNPM, RANBP2, UBC, FLNA, PPP1R13B
CCND1	KAT5	No	15	STAT3, PCNA, TP73, HDAC1, AR, UBTF, ATF2, RB1, HDAC3, ESR1, CDKN2A, RELA, EP300, BRCA1, CDK1
CCND1	BRAF	No	2	HSPA8, MAPK1
CCND1	TLR4	No	1	HSPA8
CCND1	APC	No	6	TAF1, BTRC, XPO1, PCNA, RANBP9, GSK3B
CCND1	PTPRJ	No	2	KLK9, KLK7
PTPN12	MCC	No	1	APP
PTPN12	KAT5	No	1	APP
PTPN12	TLR2	No	1	EGFR
PTPN12	PTPRJ	No	2	GRB2, EGFR
MCC	KAT5	No	2	VHL, APP
MCC	APC	No	7	ERBB2IP, STRN4, STRN, CSNK1E, STRN3, SNRNP200, MYH10
KAT5	TLR2	No	1	CREBBP
KAT5	BRAF	No	3	YWHAG, PRKCE, HSP90AA1
KAT5	APC	No	4	CREBBP, GOLGA2, MAPRE1, PCNA
TLR2	TLR4	No	6	IRAK1, TIRAP, TLR1, TOLLIP, MYD88, LY96
TLR2	APC	No	1	CREBBP
TLR2	PTPRJ	No	1	EGFR
BRAF	TLR4	No	1	HSPA8
BRAF	APC	No	3	HSPA5, YWHAQ, SFN
TLR4	APC	No	1	HGS
APC	PTPRJ	No	5	CYP17A1, TRIM25, HOXC6, CASC3, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BUB1B	DLC1	No	1	FBXW7
CTNNB1	EP300	Yes	3	LRRFIP1, TCF7L2, CEBPA
CTNNB1	TP53	No	2	CREBBP, EP300
CTNNB1	APC	No	1	KCTD1
AURKA	EP300	No	1	TP53
AURKA	TP53	Yes	0
EP300	TP53	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MT-CO1	BAX	No	-	1	CYCS
MT-CO1	CTNNB1	No	-	1	MT-CO2
MT-CO1	AKT1	No	-	1	MT-CYB
BUB1B	MLH3	No	-	1	BRCA2
BUB1B	BAX	No	-	1	UBC
BUB1B	CTNNB1	No	-	13	KAT2B, BIRC5, PKP4, AJUBA, RPS27A, PLK1, CDC42, XPO1, INCENP, UBC, BRCA1, HDAC1, HDAC9
BUB1B	AKT1	No	-	13	KAT2B, BIRC5, UBB, UBE2D1, AURKA, RPS27A, BMI1, CDC42, CCNB1, UBC, BRCA1, PCGF2, HDAC9
BUB1B	ODC1	No	-	42	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
BUB1B	AXIN2	No	-	45	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, UBA52, PSMD4, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
BUB1B	PIK3CA	No	-	1	CDC42
BUB1B	DCC	No	-	1	CDC42
BUB1B	AURKA	Yes	binding	89	NDC80, INCENP, PSMC3, PSMC4, CLASP1, MAPRE2, NDEL1, PSMD1, PSME2, PSMB5, PSMD11, ANAPC5, UBE2C, PSMD5, BARD1, PSMB1, PSMD6, PSMD10, PSME3, UBE2D1, ANAPC2, PTTG1, PLK1, PSMD9, UBE2E1, ANAPC4, NEK2, UBB, PSMD3, KIF11, PSME1, MAPRE1, PSMD4, CENPA, PSMA7, BUB1, PSME4, PSMC5, PSMB2, CCNB1, UBC, PSMA3, CDC26, PSMC6, ANAPC10, PSMA8, PAFAH1B1, PSMA5, BRCA1, CDC20, BIRC5, PSMB10, PSMD12, PSMD7, CENPE, FZR1, PLK3, CDK1, PSMC1, PSMB3, PSMB11, CKAP5, CDC16, MAD2L1, ANAPC11, AURKB, KIF2C, PSMF1, RPS27A, PSMC2, PSMB4, CDC27, PSMA1, UBA52, CDC23, PSMB6, MAPRE3, PSMA6, BUB3, PSMD14, PSMD8, PSMD2, ANAPC1, ANAPC7, AJUBA, PSMD13, PSMB7, NDE1, PSMA4
BUB1B	DLC1	No	-	1	CDC42
BUB1B	FLCN	No	-	2	PKP4, SEC13
BUB1B	TRIM28	No	-	5	UBC, ZWINT, HDAC1, MIS12, SUMO1
BUB1B	EP300	No	-	8	KAT2B, UBE2D1, UBB, HDAC1, ANAPC5, UBC, HDAC9, BRCA1
BUB1B	TP53	No	-	31	KAT2B, STAG2, CDK1, XPO1, AURKB, HDAC9, RPS27A, SUMO1, UBB, BMI1, PSMD10, CLIP1, BRCA1, CDC20, UBA52, BIRC5, HDAC1, BARD1, RNF2, BUB1, PSME3, MAD1L1, BRCA2, UBE2D1, PTTG1, PLK3, AURKA, PLK1, CCNB1, UBC, CUL7
BUB1B	CCND1	No	-	58	KAT2B, PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, CDK1, XPO1, PSMA8, CDC42, PSMD14, PSMD1, PSMC3, PCGF2, HDAC9, PSMF1, RPS27A, PSMD3, SUMO1, PSMD2, UBB, CDC27, PSMD11, UBA52, PSME2, BRCA1, PSMA1, PSMD5, PSMD4, BIRC5, PSMD12, PSMB6, HDAC1, PSMB5, PSMA7, PSMA4, PSMA6, RBX1, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMC2, PSMD9, PSME4, PSMC5, PSMB2, PSMD13, CCNB1, PSMA5, UBC, PSMA3, PSMB7
BUB1B	KAT5	No	-	7	KAT2B, SUMO1, HDAC1, PLK1, MAPRE1, CCNB1, UBC
BUB1B	BRAF	No	-	1	UBC
BUB1B	TLR4	No	-	1	UBC
BUB1B	PTPRJ	No	-	1	UBC
MLH3	BAX	No	-	1	RPA1
MLH3	CTNNB1	No	-	1	CDK2
MLH3	RAD54B	No	-	7	WRN, MUS81, DMC1, BLM, RAD51C, RECQL, RAD51
MLH3	AURKA	No	-	1	CDK2
MLH3	TRIM28	No	-	0
MLH3	EP300	No	-	3	RPA1, CDK2, PCNA
MLH3	TP53	No	-	13	PMS2, BRCA2, CDK2, WRN, MLH1, RPA1, BLM, CDK4, PCNA, RPA3, MSH6, MSH2, RAD51
MLH3	CCND1	No	-	3	CDK4, CDK2, PCNA
MLH3	KAT5	No	-	0
BAX	CTNNB1	No	-	18	STAT3, AKT1, GJA1, MAPK8, EP300, CTBP1, CREBBP, NFKB1, BCL2L1, MMP2, RUNX3, JUN, BCL2, RELA, UBC, MYC, GSK3B, SIRT1
BAX	AKT1	Yes	binding, ptmod	33	BCL2L1, TIMP1, RUNX2, BCL2L2, TP53, XIAP, YAP1, BCL2L11, GJA1, NFKB1, PARK7, GSK3B, APAF1, CLU, SNCA, SIRT1, MCL1, JUN, PTEN, BAD, EP300, VDAC1, STAT3, BCL2, CREBBP, HSPA4, MMP2, RUNX3, IL6, RB1, UBC, MYC, RELA
BAX	ODC1	No	-	5	MAX, UBC, MYC, EP300, CREBBP
BAX	AXIN2	No	-	4	UBC, MYC, GSK3B, RUNX2
BAX	PIK3CA	No	-	13	SP1, BCL2L1, RELA, KITLG, SDC2, CAPN1, STAT3, TP53, AKT1, PTEN, MYC, GSK3B, NFKB1
BAX	AURKA	No	-	4	UBC, GSK3B, TP53, AKT1
BAX	DLC1	No	-	1	AKT1
BAX	TRIM28	No	-	5	UBC, MYC, SIRT1, STAT3, TP53
BAX	PLA2G2A	No	-	1	AKT1
BAX	EP300	Yes	activation, binding	22	AKT1, RUNX2, TP53, CTBP1, SP1, MAPK8, BCL2, RPA1, SIRT1, MAX, JUN, TAF1, RELA, NFKB1, STAT3, CREBBP, JMY, RUNX3, RB1, UBC, MYC, ING1
BAX	FGFR3	No	-	3	SH3GLB1, STAT3, KITLG
BAX	TP53	Yes	activation, binding	44	BCL2L1, AKT1, RUNX2, HSPA4, POU4F2, TAF1, TP53BP2, IL6, CTBP1, SP1, MAPK8, BCL2, NFKB1, PARK7, RB1, RPA1, CLU, SIRT1, MCL1, EP300, BID, SERPINB5, UBC, JUN, PTEN, PPP1R13B, GSK3B, APEX1, PMAIP1, CREBBP, STAT3, BBC3, XRCC6, BAK1, MMP2, RUNX3, BHLHE40, APAF1, GPX1, MAX, MYC, RELA, POU4F1, ING1
BAX	CCND1	No	-	24	PTEN, TP53, YAP1, CTBP1, SP1, MAPK8, BCL2, GSK3B, BHLHE40, TAF1, JUN, AKT1, RELA, EP300, PMAIP1, STAT3, CREBBP, NFKB1, GNB2L1, RUNX3, IL6, RB1, UBC, MYC
BAX	KAT5	No	-	11	STAT3, EP300, CREBBP, TP53, HSPD1, TAF1, MAX, MYC, NFKB1, UBC, SIRT1
BAX	TLR2	No	-	6	STAT3, MMP2, IL6, RELA, HSPD1, NFKB1
BAX	BRAF	No	-	3	UBC, MCL1, AKT1
BAX	TLR4	No	-	12	STAT3, AKT1, NFKB1, S100A8, HSPA4, MAPK8, UBC, IL6, TIMP1, HSPD1, RELA, GSK3B
BAX	PTPRJ	No	-	1	UBC
PDGFRL	AKT1	No	-	2	PHLPP2, PHLPP1
PDGFRL	FGFR3	No	-	2	PHLPP2, PHLPP1
CTNNB1	AKT1	Yes	activation, binding, catalysis	97	PTPN1, TJP1, CDC42, RAP1A, HDAC9, YWHAB, GJA1, HTT, YWHAH, ACTA1, FOXO3, GSK3A, BDNF, JUN, RELA, MYOD1, MMP9, MTOR, PIK3R1, YWHAG, TERT, FLT3, IRF3, KAT2B, AR, HNRNPA1, YWHAE, EZH2, EZR, PTGS2, FOS, RHOA, FOXO4, GLI1, IGF1, CBY1, CDH1, MMP2, CDKN1B, UBC, YWHAQ, HIF1A, ZYX, PPP2R5D, BCL2L1, SMAD4, BTRC, RAP1B, CHUK, IQGAP1, NFKB1, CCND1, AXIN1, ERBB3, FOXO1, SMAD3, BRCA1, SFN, FBXW11, PPP2R5A, BIRC5, HSPB3, NOTCH1, SMAD2, IKBKB, CDH2, VEGFA, EP300, MAPK14, NF2, RAC1, PRKCZ, IGF2, RUNX3, SIRT1, EFNA1, RAC3, PTPN11, FOXM1, HSPB2-C11ORF52, SNAI1, SNAI2, WNT3A, RPS27A, BCL2, SMAD7, PIK3CA, COPS5, YWHAZ, AKT2, SLC9A3R1, SRC, GSK3B, STAT3, ILK, CREBBP, MYC
CTNNB1	ODC1	No	-	4	UBC, MYC, EP300, CREBBP
CTNNB1	AXIN2	Yes	activation, binding	30	TCF7, SIAH1, TCF7L2, DVL2, CTNNBIP1, RPS27A, DACT1, CACYBP, SMAD7, CSNK1A1L, AXIN1, WNT3A, TBL1X, LRP6, GSK3A, LEF1, TBL1XR1, TCF7L1, APC2, CSNK1A1, DVL1, GSK3B, TNIK, MED12, DVL3, JUP, CDX1, CDX2, UBC, MYC
CTNNB1	PIK3CA	Yes	activation	59	MYC, BCL2L1, EGFR, MET, PRKCZ, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, RAP1A, RAP1B, VEGFA, CTNNA1, HGF, KDR, GSK3B, RHOA, ACTA1, PTK2, EPHA2, ERBB2, ERBB3, DLG1, SMAD2, SMAD3, YWHAZ, AKT2, IGF1, PRKCI, AR, PTPN1, NOTCH1, BDNF, SLC9A3R1, CDH1, AKT1, SRC, FYN, NFKB1, PRKCA, STAT3, GDNF, CDH2, RAC1, PTPN11, IGF1R, RELA, MTOR, PIK3R1, ERBB4, FLT3, EGF, GFRA1, EFNA1, FGFR1, CCND1, RAC3
CTNNB1	DCC	No	-	11	RAC1, EZR, RHOA, PTPN11, PTK2, SIAH1, CDC42, SRC, ROBO1, FYN, SLIT1
CTNNB1	AURKA	No	-	21	RPS27A, FOXM1, HIST3H3, AKT1, CPEB1, ILK, CDK2, AJUBA, BIRC5, YWHAE, CSNK1D, PLK1, UBC, TUBA1A, PPP2R5D, INCENP, CSNK1E, YWHAG, BRCA1, GSK3B, PRKACA
CTNNB1	DLC1	No	-	5	RAC3, RHOA, CDC42, AKT1, CDH1
CTNNB1	FLCN	No	-	2	CCND1, PKP4
CTNNB1	TRIM28	No	-	7	STAT3, HDAC1, SIRT1, UBC, FYN, MYC, CDKN1B
CTNNB1	PLA2G2A	No	-	2	PTGS2, AKT1
CTNNB1	EP300	Yes	activation	78	KAT2B, AR, RELA, FOXM1, CAMK4, IRF3, SMAD4, MYOD1, TGFBR1, MAPK14, TERT, HDAC9, FOS, KAT5, PTGS2, MAPK8, HNF1A, TCF7, PRKX, CTBP1, KLF4, SMAD7, SFN, TCF3, JUP, HDAC7, COPS5, MED12, NCOA2, PRKACG, CA9, FOXO4, FOXO3, HIPK2, TCF7L1, PRKACB, PRKACA, TCF4, FOXO1, LEF1, SMAD3, HDAC1, SOX9, NOTCH1, CDH1, UBC, MED1, TCF7L2, JUN, RAC3, MITF, SRC, CCND2, VEGFA, CEBPA, NFKB1, BRCA1, FHL2, STAT3, SMAD2, CDK2, PITX2, BCL2, PPARD, AKT1, CREBBP, HDAC2, ADIPOQ, CDX1, RUNX3, IL8, SIRT1, SMARCA4, SRY, MYC, CCND1, PML, HIF1A
CTNNB1	FGFR3	No	-	7	STAT3, HGF, FGF4, IGF1, EGF, VEGFA, EFNA1
CTNNB1	TP53	No	-	115	AKT1, MMP9, EGFR, HDAC9, FOXO3, MYO6, HTT, PTK2, RBBP5, TFF2, DKK1, MAPK12, CABLES1, CA9, ELAVL1, CSNK1A1, JUN, SPN, EP400, SKP1, BTRC, MTOR, YWHAG, SFN, MYOG, KAT2B, BCL2L1, CSNK1E, YWHAE, EZH2, PLK1, ASH2L, PTGS2, MAPK8, HGF, HIC1, ABL1, SMARCA4, PKD1, NUMB, MAPK9, CDH1, MITF, IGF1R, HDAC2, TERT, MMP2, PSENEN, UBC, HIF1A, NME1, AR, SMAD4, CSNK1D, VCAN, KAT5, FOS, CDK5R1, MAPK11, GSK3B, CCND1, CUL4A, AXIN1, SMAD3, FOXO1, BRCA1, HIPK2, SIRT1, BIRC5, HSPB3, HDAC1, PSEN1, NOTCH1, SMAD2, MED1, VEGFA, EP300, MAPK14, FHL2, CDK2, CSNK2A1, RUNX3, HNF4A, PTPN11, FOXM1, MET, HSPB2-C11ORF52, SNAI1, XPO1, SNAI2, CTBP1, MUC1, RPS27A, BCL2, PML, SMAD7, PIK3CA, EPHA2, ERBB2, COPS5, YWHAZ, RUVBL1, ID2, TOP2A, BDNF, NANOG, NFKB1, STAT3, CREBBP, RELA, IKBKB, DSC3, MYC, KLF4, ERBB4
CTNNB1	CCND1	Yes	activation	93	AKT1, CDC42, EGFR, HDAC9, MAPK14, ELAVL1, JUN, ABL1, KLK3, SKP1, MTOR, PIK3R1, TERT, CYR61, KAT2B, RAC1, HNRNPA1, TCF7, IL8, TCF7L2, ATOH1, MAPK8, CCNE1, KLF4, CDKN1B, HBP1, IGF1, CDH1, TGFBR2, HDAC2, CDX1, HNF4A, UBC, TLE4, FGFR1, SOX6, BMP4, PRL, CDC73, AR, SMAD4, HINT1, BTRC, FOS, CHUK, GSK3B, ERBB3, FOXO1, BRCA1, BIRC5, LEF1, HDAC1, NOTCH1, AES, CDH2, EP300, SMARCA4, FHL2, NF2, CDK2, CTNND1, IGF2, RUNX3, EZH2, RAC3, CUL1, XPO1, SNAI2, MAPK12, CTBP1, MUC1, RPS27A, HNF1A, BCL2, TLE1, PIK3CA, NR5A2, ERBB2, WNT3A, TCF7L1, CDX2, ID2, BDNF, SRC, CCND2, NFKB1, CDH4, STAT3, ILK, CREBBP, RELA, ADAM10, MYC
CTNNB1	PTPN12	No	-	4	SRC, CTNND1, FLT3, PTK2
CTNNB1	KAT5	Yes	activation, binding	34	KAT2B, AR, HIST3H3, RUVBL2, SOX9, NME1, HINT1, TRRAP, RUVBL1, CCND2, TCF4, EP300, KLF4, HDAC7, AXIN1, KLK3, GDNF, SIRT1, NOTCH1, LEF1, HDAC1, EP400, MED1, ABL1, NFKB1, STAT3, PITX2, CREBBP, PHF17, TCF7L2, PLK1, SMARCA4, UBC, MYC
CTNNB1	TLR2	No	-	15	HIF1A, STAT3, MMP9, RELA, RAC1, VCAN, MMP2, IKBKB, IL8, CHUK, EGFR, SRC, MAPK14, NFKB1, IRF3
CTNNB1	BRAF	No	-	15	YWHAB, IQGAP1, PRKCA, YWHAQ, YWHAH, YWHAE, MAP2K6, YWHAG, AKT1, RAP1A, UBC, PRKACA, RAP1B, SFN, YWHAZ
CTNNB1	TLR4	No	-	21	NOTCH1, STAT3, AKT1, NANOG, MAPK8, NFKB1, EGFR, IKBKB, RAC1, MTOR, UBC, MMP9, IL8, CHUK, RELA, SRC, CDX2, EZR, GSK3B, RHOA, IRF3
CTNNB1	PTPRJ	Yes	activation	12	FLT3, HGF, MET, RET, CTNND1, UBC, TJP1, CDH5, EGFR, KDR, SRC, CTNNA1
AKT1	ODC1	No	-	4	UBC, MYC, EP300, CREBBP
AKT1	AXIN2	No	-	13	GSK3A, CTNNB1, RUNX2, SMAD7, RPS27A, AXIN1, ESR1, PPP2CB, UBC, UBB, GSK3B, MYC, WNT3A
AKT1	RAD54B	No	-	1	S100A11
AKT1	PIK3CA	Yes	activation, binding	108	ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
AKT1	DCC	No	-	12	ELMO1, RAC1, APPL1, PLCG1, PTPN11, PAK1, CASP9, SRC, CDC42, EZR, DOCK1, RHOA
AKT1	AURKA	Yes	activation, binding	21	RALA, BIRC5, UBB, PPP2R5D, FOXM1, UBC, ARHGEF7, YWHAE, RPS27A, TP53, GADD45A, ILK, UBE2D1, MDM2, YWHAG, HSP90AA1, CCNB1, PPP2R1A, BRCA1, GSK3B, PAK1
AKT1	DLC1	Yes	binding	9	SERPINE1, RHOA, CDH1, INS, RPS6KB1, CDC42, RAC3, RHOC, RHOB
AKT1	FLCN	No	-	2	CCND1, RPS6KB1
AKT1	TRIM28	No	-	10	STAT3, MDM2, NCOR1, TP53, DNMT1, SIRT1, UBC, E2F1, MYC, CDKN1B
AKT1	PLA2G2A	Yes	binding, ptmod	2	PTGS2, PLA2G6
AKT1	EP300	Yes	activation, binding	95	MEF2D, TP53, CREB3L4, HDAC9, HSP90AA1, STAT5A, CTNNB1, SMAD5, FOXO3, BAX, CREB5, RPS6KB1, NR4A1, RELA, MYOD1, CREB3L2, TERT, ANGPTL4, IRF3, KAT2B, AR, NRIP1, RUNX2, CDKN1A, IGFBP3, UBB, SKP2, PTGS2, EGR1, FOS, HDAC3, FOXO4, RPS6KB2, NOTCH1, ESR1, GAPDH, RARA, MMP1, CDH1, FKBP4, GADD45A, MDM4, SERPINH1, UBC, MEF2C, HIF1A, PELP1, ATF4, SMAD4, CREB3L3, PARP1, SLC2A1, CREB1, CRTC2, NCOR1, NOS3, FOXM1, CCND1, TAL1, SMAD3, FOXO1, BRCA1, SFN, SIRT1, ARNT, CREB3, STAT3, ATF2, CREB3L1, VEGFA, MAPK14, EDN1, UBE2D1, RUNX3, RB1, RAC3, MDM2, RXRG, BCL2, SMAD7, NCOR2, COPS5, E2F1, CSF2, STAT5B, SMAD2, SRC, NFKB1, MEF2A, HSPA8, FABP4, CREBBP, JUN, MYC, LEP
AKT1	FGFR3	No	-	31	PGF, MDM2, SH2B1, FGF2, HSP90AB1, PDGFB, ANGPT2, HSP90AA1, ANGPT1, FGF1, SOS1, CBLB, SHC1, ANGPT4, IGF1, PHLPP1, HRAS, SOX2, PHLPP2, TRAF6, VEGFA, GRB2, BMP2, STAT3, FGF13, IRS1, INS, FGF9, EFNA1, FGF21, NEDD4
AKT1	TP53	Yes	binding, activation, expression	139	WWOX, RELA, CAV1, NPM1, HDAC9, VEGFA, FOXO3, HTT, CXCL12, STAT5A, COPS5, MAPK14, BAX, BDNF, JUN, NR4A1, FOXM1, MMP9, MTOR, MCL1, YWHAG, ESR1, KAT2B, BCL2L1, RUNX2, YWHAE, IGFBP3, SERPINE1, FGF2, STUB1, PTGS2, PIAS2, EGR1, PARK7, THBS1, RB1, CAT, CCNA2, SFN, TSC2, GAPDH, AR, CDH1, ANKRD2, HSP90AA1, LGALS3, AURKA, TERT, MMP2, GADD45A, S100B, MDM4, CCNB1, UBC, HIF1A, SP7, MMP1, SLC2A4, SMAD4, BTRC, CREB1, CFLAR, HSPA5, FOS, NCOR1, PHB, NOS3, PHF20, GDF15, NFKB1, CCND1, CD44, KRAS, BMI1, AXIN1, SMAD3, RAF1, BRCA1, SIRT1, WT1, BIRC5, FOXO1, HSPB3, HRAS, NOTCH1, SMAD2, NFE2L2, PTEN, PPP2R1A, ICAM1, EP300, SHH, UBE2D1, CHEK1, EZH2, RUNX3, APAF1, HMOX1, CDC25C, PTPN11, MDM2, HSPB2-C11ORF52, SNAI1, TOPBP1, SNAI2, WEE1, BAIAP2L1, UBB, RPS27A, BCL2, SMAD7, PPP2R4, PIK3CA, CLU, DNMT1, SKP2, TGFB1, PPP2R5C, YWHAZ, CDKN1A, SERPINH1, TRAF6, STAT5B, CTGF, PARP1, GSK3B, MYC, STAT3, HSPA8, POLI, CREBBP, HSPA4, IKBKB, YBX1, IL6, ATIC, LEP, MAP3K8, PDCD4
AKT1	CCND1	Yes	activation, binding	100	NRF1, PTEN, TP53, CDC42, HDAC9, PCGF2, STAT5A, CTNNB1, MAPK14, SLC3A2, F2R, BDNF, JUN, RELA, MTOR, INS, PIK3R1, ESR1, FHIT, KAT2B, RAC1, HNRNPA1, PDCD4, CSF2, EZH2, FGF2, LGALS3, FABP4, HDAC3, CHUK, HEXIM1, SRPK2, IGF1, TSC2, CDH1, TERT, GADD45A, RAC3, CCNB1, UBC, PELP1, ATF4, AR, SMAD4, BTRC, KRAS, YAP1, FOS, GCG, NFKB1, CD44, CREB1, ERBB3, FOXO1, BRCA1, WT1, BIRC5, RAF1, HRAS, NOTCH1, ATF2, CDH2, EP300, SHH, EDN1, NF2, MAP3K5, IGF2, RUNX3, ILK, RB1, CDKN1B, SNAI2, ARHGEF2, UBB, WNT3A, RPS27A, BCL2, PIK3CA, NCOR2, E2F1, CDKN1A, CYLD, STAT5B, SOX2, SRC, PAK1, GSK3B, STAT3, HSPA8, EGR1, GRN, IL3, CREBBP, YBX1, IL6, EIF4EBP1, MYC, LEP, FOXA1
AKT1	PTPN12	No	-	6	PDGFRB, CSK, FLT3, SRC, GRB2, SHC1
AKT1	KAT5	No	-	20	KAT2B, FKBP5, STAT3, CCNB1, MDM2, NOTCH1, EP300, CREBBP, CHEK1, AR, TP53, AXIN1, DNMT1, ATF2, CTNNB1, UBC, MYC, NFKB1, ESR1, SIRT1
AKT1	TLR2	No	-	23	RAC1, MMP9, SERPINE1, LGALS3, CHUK, HSP90B1, RETN, MAPK14, TLR4, CSF2, TRAF6, IKBKB, RELA, SRC, ICAM1, NFKB1, STAT3, HSPA8, MMP1, MMP2, IL6, HIF1A, IRF3
AKT1	BRAF	Yes	binding	24	HSP90AB1, YWHAE, PPP2CA, RRAS, RAP1A, RAP1B, YWHAB, IQGAP1, YWHAH, KRAS, RAF1, RPS6KB2, YWHAZ, RHEB, MCL1, HRAS, HSP90AA1, PPP2R2B, PPP2R1A, CDC37, YWHAG, SFN, UBC, YWHAQ
AKT1	TLR4	Yes	activation, binding, ptmod	34	RAC1, TIMP1, HSPA4, DECR1, MMP9, MTOR, EZR, CHUK, S1PR1, HSP90B1, GSK3B, RHOA, STAT5A, HMOX1, NOTCH1, TRAF6, IKBKB, NOX1, RELA, SRC, ICAM1, NFKB1, STAT3, HSPA8, BIRC2, STAT5B, NOX4, INS, IL6, EPOR, BMP2, UBC, BCL10, IRF3
AKT1	PTPRJ	No	-	9	FLT3, PDGFRB, LCK, UBC, TJP1, CTNNB1, SRC, GAB1, PDGFB
ODC1	AXIN2	No	-	43	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, MYC, PSMA3, PSMB7
ODC1	PIK3CA	No	-	1	MYC
ODC1	AURKA	No	-	44	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, OAZ1, PSMC3, PSMD1, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, AZI1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, PSMD9, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
ODC1	TRIM28	No	-	2	UBC, MYC
ODC1	EP300	Yes	activation, binding	4	MAX, UBC, MYC, CREBBP
ODC1	TP53	No	-	8	PSME3, CREBBP, UBC, MAX, NQO1, EP300, MYC, PSMD10
ODC1	CCND1	No	-	45	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, EP300, PSMD10, PSMD7, PSME3, PSMB5, PSME4, CREBBP, PSMC5, PSMB2, PSMD13, PSMA5, UBC, MYC, PSMA3, PSMB7
ODC1	KAT5	No	-	5	MAX, UBC, MYC, EP300, CREBBP
ODC1	BRAF	No	-	1	UBC
ODC1	TLR4	No	-	1	UBC
ODC1	PTPRJ	No	-	1	UBC
AXIN2	PIK3CA	No	-	4	MYC, GSK3B, ESR1, CTNNB1
AXIN2	DCC	No	-	1	SIAH1
AXIN2	AURKA	No	-	47	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMD3, PSMC2, GSK3B, PSMD2, PSMD11, UBA52, PSME2, PSMA1, PKD2, PSMD4, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, PSMB2, PSMD13, PSMA5, UBC, PSMA3, PSMB7
AXIN2	TRIM28	No	-	2	UBC, MYC
AXIN2	EP300	No	-	14	LEF1, RUNX2, TCF7, TCF7L1, SMAD7, TCF7L2, CDX1, JUP, ESR1, CTNNB1, UBC, UBB, MYC, MED12
AXIN2	TP53	No	-	13	RPS27A, PSME3, RUNX2, UBA52, SMAD7, CSNK1A1, AXIN1, ESR1, UBC, UBB, GSK3B, MYC, PSMD10
AXIN2	CCND1	No	-	58	PSMC4, PSME1, PSMC1, PSMC6, TCF7, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD9, PSMC3, PSMD1, PSMF1, PSMD3, PSMB3, PSMC2, GSK3B, PSMD2, PSMD11, WNT1, UBA52, WNT3A, CTNNB1, PSMA1, WNT5A, PSMD4, ESR1, LEF1, PSMB6, PSMD5, PSMA7, RPS27A, PSMA6, TCF7L1, PSMB1, PSMB10, PSMD8, PSME2, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, TCF7L2, CDX1, PSMB2, PSMD13, CDX2, PSMA5, UBC, MYC, PSMA3, PSMB7, PSMA4
AXIN2	KAT5	No	-	7	ESR1, LEF1, TCF7L2, AXIN1, CTNNB1, UBC, MYC
AXIN2	TLR2	No	-	1	WNT5A
AXIN2	BRAF	No	-	1	UBC
AXIN2	TLR4	No	-	3	UBC, GSK3B, CDX2
AXIN2	PTPRJ	No	-	2	UBC, CTNNB1
RAD54B	TRIM28	No	-	1	UBE2I
RAD54B	EP300	No	-	1	FEN1
RAD54B	TP53	No	-	4	UBE2I, RAD51, BLM, WRN
RAD54B	KAT5	No	-	1	UBE2I
PIK3CA	DCC	No	-	16	RAC1, CDC42, NTN1, MAP2K2, PTPN11, PTK2, UNC5B, CASP9, YES1, RHOA, SRC, PLCG1, FYN, APPL1, MAP2K1, BCAR1
PIK3CA	AURKA	No	-	3	GSK3B, TP53, AKT1
PIK3CA	DLC1	No	-	12	INS, TNS1, AKT1, RHOA, CDH1, RPS6KA1, RPS6KB1, CDC42, TNS3, TENC1, RHOG, RAC3
PIK3CA	FLCN	No	-	2	CCND1, RPS6KB1
PIK3CA	TRIM28	No	-	6	STAT3, NR3C1, TP53, CCND3, FYN, MYC
PIK3CA	PLA2G2A	No	-	4	GNAQ, GNA11, IL1B, AKT1
PIK3CA	EP300	No	-	29	AR, PELP1, AKT1, TP53, THRB, PGR, SP1, CCND1, CREB1, SMAD3, CTNNB1, RPS6KB2, CSF2, IL1B, THRA, NOTCH1, SMAD2, RPS6KB1, CDH1, RELA, SRC, VEGFA, NFKB1, STAT3, NR3C1, SGK1, ESR1, MYC, RAC3
PIK3CA	FGFR3	No	-	25	FIGF, IRS1, PGF, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, SOS1, CBLB, SHC1, PDGFA, HGF, HRAS, GRB2, VEGFA, VEGFC, STAT3, CBL, CBLC, INS, IGF1, EGF, EFNA1
PIK3CA	TP53	Yes	activation, expression	42	BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
PIK3CA	CCND1	Yes	activation	46	RAC1, PELP1, RELA, FIGF, AR, TP53, CTNND1, CDC42, KRAS, EGFR, PGR, AKT1, CCND3, CRKL, SP1, IL4, GSK3B, MAP2K1, CREB1, ERBB2, ERBB3, CTNNB1, ESR1, CSF2, RAF1, HRAS, NOTCH1, BDNF, CDH1, CDH2, SRC, NFKB1, MYC, STAT3, IL3, AGAP2, MAP3K5, MTOR, INS, PIK3R1, PTEN, SGK1, IGF1, VEGFC, FGFR1, RAC3
PIK3CA	PTPN12	No	-	12	PXN, PDGFRB, GSN, CSK, JAK2, CTNND1, PTK2, FLT3, SRC, GRB2, SHC1, BCAR1
PIK3CA	KAT5	No	-	9	STAT3, AR, GDNF, ESR1, NOTCH1, TP53, CTNNB1, MYC, NFKB1
PIK3CA	TLR2	No	-	9	STAT3, RELA, IL4, RAC1, CSF2, PXN, EGFR, SRC, NFKB1
PIK3CA	BRAF	No	-	16	MAP2K2, KRAS, RAP1A, RPS6KA2, CRK, HRAS, RRAS, PRKCD, RAF1, AKT1, PRKCA, RPS6KB2, RAP1B, MRAS, YWHAZ, MAP2K1
PIK3CA	TLR4	No	-	21	NOTCH1, STAT3, EGFR, RAC1, NFKB1, RHOA, TREM2, S1PR1, JAK2, IL1B, INS, PLCG2, LYN, AKT1, RELA, IL4, SRC, SYK, GSK3B, MTOR, FCGR2A
PIK3CA	PTPRJ	No	-	14	CTNNB1, PDGFRB, MET, RET, FLT3, HGF, LCK, CTNND1, EGFR, KDR, SRC, PDGFB, GAB1, CTNNA1
DCC	AURKA	No	-	1	PAK1
DCC	DLC1	No	-	2	RHOA, CDC42
DCC	TRIM28	No	-	1	FYN
DCC	EP300	No	-	1	SRC
DCC	TP53	No	-	5	MYO10, NTN1, UNC5A, PTPN11, PTK2
DCC	CCND1	No	-	5	SRC, MAP2K1, CDC42, PAK1, RAC1
DCC	PTPN12	No	-	4	SRC, NCK1, BCAR1, PTK2
DCC	TLR2	No	-	2	SRC, RAC1
DCC	BRAF	No	-	2	MAP2K2, MAP2K1
DCC	TLR4	No	-	4	SRC, RHOA, EZR, RAC1
DCC	PTPRJ	No	-	1	SRC
AURKA	DLC1	No	-	1	AKT1
AURKA	TRIM28	No	-	3	UBC, TP53, MDM2
AURKA	PLA2G2A	No	-	1	AKT1
AURKA	EP300	No	-	14	PRKACA, FOXM1, GATA3, UBE2D1, CDK2, TP53, GADD45A, MDM2, HSP90AA1, AKT1, UBC, BRCA1, ANAPC5, UBB
AURKA	FGFR3	No	-	2	MDM2, HSP90AA1
AURKA	TP53	Yes	activation, binding	37	CDK1, CASP1, AKT1, FOXM1, YWHAE, BIRC5, CSNK1D, AURKB, UBB, RPS27A, CSNK1E, PLK4, PSMD10, BRCA1, CDC20, MAP9, MDM2, UBE2N, UBA52, BARD1, HSP90AA1, BUB1, PPP2R1A, GSK3B, HMMR, PSME3, CDK2, UBE2D1, PTTG1, PLK3, PLK1, GADD45A, YWHAG, CCNB1, UBC, KIF23, FBXW7
AURKA	CCND1	No	-	59	PSMC4, PSME1, CEP57, PSMB10, PSMB3, PSMA5, PSMB11, PSMB4, CDK1, TP53, PSMA8, PSMD14, PSMC1, PSMD1, PSMC3, PSMD9, PSMF1, CDK3, PSMB2, RPS27A, PSMC2, PSMC6, GSK3B, PSMD2, UBB, CDC27, PSMD11, PSME2, BRCA1, PSMA1, UBA52, PSMD4, BIRC5, PSMB6, PSMD5, PSMA7, PSMD3, PSMA6, PSMB1, AKT1, PSMD8, PAK1, PSMD6, PSMD10, PSMD12, PSMD7, PSME3, PSMB5, CDK2, ILK, PSME4, PSMC5, GADD45A, PSMD13, CCNB1, UBC, PSMA3, PSMB7, PSMA4
AURKA	PTPN12	No	-	1	NEDD9
AURKA	KAT5	No	-	8	HIST3H3, MDM2, PLK1, MAPRE1, H3F3B, TP53, CCNB1, UBC
AURKA	TLR2	No	-	1	DCN
AURKA	BRAF	No	-	7	YWHAE, HSP90AA1, UBC, YWHAG, AKT1, PPP2R1A, PRKACA
AURKA	TLR4	No	-	5	UBC, GSK3B, UBE2N, AKT1, DCN
AURKA	PTPRJ	No	-	1	UBC
DLC1	FLCN	No	-	1	RPS6KB1
DLC1	PLA2G2A	No	-	1	AKT1
DLC1	EP300	No	-	4	RAC3, RPS6KB1, AKT1, CDH1
DLC1	FGFR3	No	-	1	INS
DLC1	TP53	No	-	3	AKT1, CDH1, SERPINE1
DLC1	CCND1	No	-	6	CDH1, INS, CDC42, AKT1, RHOBTB2, RAC3
DLC1	TLR2	No	-	1	SERPINE1
DLC1	BRAF	No	-	1	AKT1
DLC1	TLR4	No	-	3	INS, RHOA, AKT1
FLCN	EP300	No	-	2	CCND1, RPS6KB1
FLCN	TP53	No	-	1	CCND1
FLCN	CCND1	Yes	binding, activation, expression	0
TRIM28	EP300	No	-	15	MYC, STAT3, TFDP2, MDM2, NR3C1, IRF1, TP53, TFDP1, NCOR1, UBC, MYB, E2F1, SUMO2, HDAC1, SIRT1
TRIM28	FGFR3	No	-	2	STAT3, MDM2
TRIM28	TP53	Yes	activation, binding	22	ZNF274, MYB, TRIM24, DNMT3A, NCOR1, MDM2, SUMO1, DNMT1, TFDP1, SIRT1, HDAC1, SIN3A, H2AFX, SUMO2, MYC, STAT3, NR3C1, IRF1, TP53BP1, SETDB1, UBC, UBE2I
TRIM28	CCND1	No	-	13	MYC, STAT3, TFDP2, SUMO1, HDAC1, TP53, CCND3, MYB, TFDP1, UBC, E2F1, IRF1, CDKN1B
TRIM28	KAT5	No	-	13	MYC, STAT3, MYB, MDM2, SUMO1, HDAC1, TP53, DNMT1, UBC, RAD50, H2AFX, UBE2I, SIRT1
TRIM28	TLR2	No	-	1	STAT3
TRIM28	BRAF	No	-	1	UBC
TRIM28	TLR4	No	-	2	UBC, STAT3
TRIM28	PTPRJ	No	-	1	UBC
PLA2G2A	EP300	No	-	4	PTGS2, MAPK1, AKT1, IL1B
PLA2G2A	TP53	No	-	4	PTGS2, MAPK3, MAPK1, AKT1
PLA2G2A	CCND1	No	-	2	MAPK1, AKT1
PLA2G2A	BRAF	No	-	3	MAPK3, MAPK1, AKT1
PLA2G2A	TLR4	No	-	2	IL1B, AKT1
PLA2G2A	PTPRJ	No	-	2	MAPK1, MAPK3
EP300	FGFR3	No	-	4	STAT3, VEGFA, MDM2, HSP90AA1
EP300	TP53	Yes	activation	145	RELA, PCNA, ETS2, KLF2, HDAC9, RUNX1, PAX5, HSP90AA1, FOXO3, NCOA3, KAT6A, RPA1, STAT5A, MAPK14, BCL6, CDC25A, TFDP1, JUN, NR4A1, TAF1, AKT1, EPAS1, SUMO2, CREBBP, CA9, TP63, YY1, ESR1, MAX, ZBTB16, KAT2B, NFYA, RUNX2, TWIST1, IGFBP3, MYB, BDKRB2, EWSR1, UBB, SKP2, PTGS2, MAPK8, PRMT1, SENP3, EGR1, STAT6, KLF4, DDB1, DNAJB1, NOTCH1, PPARGC1A, SFN, ZNF148, GAPDH, CDH1, MMP1, MUC2, ING4, ETS1, IRF1, HDAC2, TERT, CCNE2, SIRT2, SERPINH1, UBC, SMARCA4, TP73, KLF5, HIF1A, MITF, SUMO3, AR, SMAD4, UBE2D1, FOSL1, KAT5, FOS, NCOR1, KDM1A, NOS3, FOXM1, ABCB1, CCND1, CREB1, MTA1, SMAD3, DDB2, FOXO1, BRCA1, HIPK2, SIRT1, VHL, HDAC1, NFYB, SMAD2, MED1, VEGFA, LEP, FHL2, NEUROD1, CDK2, IRF9, RBPJ, RUNX3, RB1, TADA3, CABIN1, MDM4, MDM2, TBP, BAX, NFATC2, CDK8, REL, CTBP1, GADD45A, BCL2, PML, SMAD7, COPS5, NCL, SP1, CDKN1A, VDR, BNIP3L, ING2, STAT5B, IVL, PARP1, CARM1, NFKB1, STAT3, HSPA8, NR3C1, DDX17, PPARG, SNAPC4, MAPK1, SGK1, ING5, SP3, MYC, MAF, ING1
EP300	CCND1	Yes	activation, binding	96	IRF2, PCNA, GATA4, MYBL2, TP53, PGR, HDAC9, NCOA3, STAT5A, EDN1, CTNNB1, MAPK14, ESR1, CDC25A, TFDP1, JUN, TAF1, AKT1, TFDP2, YY1, GLI3, SMARCA4, KAT2B, AR, TCF7, CDKN1A, IL8, TCF7L2, MYB, EWSR1, UBB, SP1, MAPK8, CARM1, EGR1, KLF4, HDAC3, TERT, ESR2, CDH1, ETS1, IRF1, HDAC2, CDX1, GADD45A, UBC, PELP1, ATF4, SMAD4, FOSL1, FOS, BCL6, KLF5, CREB1, FOXO1, BRCA1, H2AFZ, VHL, LEF1, HDAC1, NOTCH1, ATF2, LEP, FHL2, SMARCA2, NEUROD1, CDK2, RBPJ, RUNX3, RB1, MAML1, RAC3, NMI, ZBTB17, SNIP1, CTBP1, HNF1A, BCL2, NCOR2, E2F1, TCF7L1, CSF2, ING2, STAT5B, SRC, CCND2, NFKB1, STAT3, HSPA8, FABP4, CREBBP, MAPK1, E2F5, MYC, RELA, SGK1
EP300	PTPN12	No	-	1	SRC
EP300	KAT5	Yes	binding	41	KAT2B, KAT2A, MDM2, AR, TP53, TCF7L2, MYB, HIST1H3A, HIST1H4A, CCND2, SOX9, TCF4, KLF4, PTMA, HDAC7, CTNNB1, SRCAP, ESR1, SIRT1, VHL, NOTCH1, SMARCA4, LEF1, HDAC1, STAT3, ATF2, UBC, MED1, TAF1, BCL3, NFKB1, PAX6, SMARCA2, PITX2, YY1, H2AFZ, ING5, NCL, MAX, MYC, CREBBP
EP300	TLR2	No	-	13	STAT3, HSPA8, CD36, CSF2, IL8, MMP1, HSPA6, HIF1A, RELA, SRC, MAPK14, NFKB1, IRF3
EP300	BRAF	No	-	11	PRKACA, AKT1, CAMK2A, MAPK1, HSP90AA1, UBC, SFN, RPS6KB2, CAMK2D, CAMK2B, CAMK2G
EP300	TLR4	No	-	19	STAT3, STAT5A, HSPA8, AKT1, CD36, MAPK8, SPI1, NFKB1, NOTCH1, PCK1, IL1B, UBC, STAT5B, IL8, RELA, SRC, PPARA, EHHADH, IRF3
EP300	PTPRJ	No	-	5	VHL, UBC, SRC, MAPK1, CTNNB1
FGFR3	TP53	No	-	10	STAT3, MDM2, HGF, HRAS, PRMT5, TRAF6, HSP90AA1, ITCH, VEGFA, FGF2
FGFR3	CCND1	No	-	11	STAT3, FIGF, HRAS, FGF7, INS, IHH, IGF1, VEGFC, SOX2, FGF2, CRKL
FGFR3	PTPN12	No	-	2	GRB2, SHC1
FGFR3	KAT5	No	-	2	STAT3, MDM2
FGFR3	TLR2	No	-	2	STAT3, TRAF6
FGFR3	BRAF	No	-	4	CRK, HRAS, HSP90AA1, HSP90AB1
FGFR3	TLR4	No	-	5	INS, STAT3, FGF10, TRAF6, BMP2
FGFR3	PTPRJ	No	-	2	PDGFB, HGF
TP53	CCND1	Yes	activation	133	TXN, ATF3, AKT1, TAF1, PTK6, EGFR, HDAC9, PCNA, CDK5, NCOA3, CDK9, STAT5A, UBA52, PMAIP1, MAPK14, TOP1, CDC25A, TFDP1, BDNF, JUN, CDK4, ABL1, MTOR, FBXW8, PSME3, SKP1, YY1, STK11, BTRC, FLI1, RND3, ESR1, KAT2B, AR, PIN1, PDCD4, PAX2, MYB, CCL2, ISG15, EWSR1, UBB, SP1, MAPK8, CARM1, EGR1, KLF4, BRCA1, SMARCA4, TSC2, CDH1, PSMD10, ETS1, CCNK, IRF1, HDAC2, STAT5B, GADD45A, CCNB1, UBC, VRK1, E2F4, BCCIP, SMARCB1, SMAD4, FOSL1, KRAS, FOS, BANP, BCL6, SUMO1, NFKB1, KLF5, CD44, CREB1, RAF1, LEP, WT1, BIRC5, FOXO1, HDAC1, NOTCH1, PTEN, SHH, EP300, MAPK12, FHL2, NEUROD1, CDK2, EZH2, RBPJ, RUNX3, RB1, MNAT1, HNF4A, VHL, CDK1, CCNA1, XPO1, SNAI2, CCNH, LGALS3, CTBP1, FGF2, MUC1, RPS27A, BCL2, IL6, PIK3CA, ERBB2, DICER1, MAPK7, HRAS, COL18A1, CDKN1A, TERT, ING2, ID2, ELAVL1, GSK3B, JDP2, EPCAM, STAT3, HSPA8, BTG2, CREBBP, MAPK1, YBX1, BHLHE40, DYRK1A, MYC, RELA, SGK1
TP53	PTPN12	No	-	1	PTK2
TP53	KAT5	Yes	activation, binding	43	KAT2B, AR, MDM2, NME1, TAF1, ZNF668, MYB, CCDC8, ACTL6A, APP, RUVBL1, SUMO1, EP300, KLF4, RCHY1, PDCD5, CCNB1, AXIN1, DNMT1, EP400, ESR1, SIRT1, VHL, NOTCH1, SMARCA4, HDAC1, STAT3, UBC, MED1, ABL1, H2AFX, NFKB1, UBE2I, USP7, YY1, CHEK1, PIAS4, PLK1, NCL, ING5, MAX, MYC, CREBBP
TP53	TLR2	No	-	20	STAT3, MMP9, HSPA8, RELA, SERPINE1, HSPA9, LGALS3, IKBKB, HMGB1, VCAN, MMP2, MMP1, IL6, TRAF6, EGFR, MAPK14, SOCS1, NFKB1, ICAM1, HIF1A
TP53	BRAF	No	-	17	AKT1, MCL1, PRKCD, MAPK1, HRAS, MAPK3, HSP90AA1, UBC, YWHAE, RAF1, YWHAG, KRAS, SFN, PPP2R1A, PIN1, MAP3K1, YWHAZ
TP53	TLR4	No	-	31	EIF2AK2, NANOG, HSPA4, TICAM2, MMP9, EGFR, STAT5B, MAPK8, GSK3B, MAP3K1, STAT5A, MAP4K4, NOTCH1, HSPA9, UBE2N, STAT3, TRAF6, IKBKB, AKT1, ICAM1, NFKB1, DUSP1, HMGB1, HSPA8, ANXA2, LYN, MTOR, IL6, HMOX1, UBC, RELA
TP53	PTPRJ	No	-	7	VHL, HGF, MET, MAPK3, MAPK1, EGFR, UBC
CCND1	PTPN12	No	-	2	SRC, CTNND1
CCND1	KAT5	No	-	31	KAT2B, AR, TP53, HINT1, TCF7L2, MYB, CCND2, SUMO1, NFKB1, KLF4, KLK3, CTNNB1, ESR1, H2AFZ, VHL, NOTCH1, CCNB1, LEF1, HDAC1, STAT3, ATF2, TAF1, ABL1, EP300, SMARCA4, SMARCA2, YY1, ING3, UBC, MYC, CREBBP
CCND1	TLR2	No	-	18	VIP, STAT3, HSPA8, RELA, IL4, WNT5A, LGALS3, RAC1, IL8, CSF2, IL6, TSC22D3, EGFR, SRC, KNG1, NFKB1, MAPK14, CHUK
CCND1	BRAF	No	-	10	PIN1, HRAS, MAPK1, PAK4, RAF1, KRAS, AKT1, UBC, MAP2K3, MAP2K1
CCND1	TLR4	No	-	27	RAC1, AKT1, PRDX1, IL8, GRP, EGFR, KNG1, CHUK, CIRBP, MAPK8, IL4, NFKB1, IL6, STAT5A, NOTCH1, STAT5B, RELA, SRC, GSK3B, STAT3, HSPA8, CDK6, MTOR, INS, VIP, CDX2, UBC
CCND1	PTPRJ	No	-	7	VHL, EGFR, MAPK1, UBC, CTNND1, CTNNB1, SRC
PTPN12	TLR2	No	-	2	SRC, PXN
PTPN12	TLR4	No	-	2	SRC, JAK2
PTPN12	PTPRJ	No	-	4	SRC, CTNND1, FLT3, PDGFRB
KAT5	TLR2	No	-	3	HSPD1, STAT3, NFKB1
KAT5	BRAF	No	-	1	UBC
KAT5	TLR4	No	-	5	HSPD1, UBC, STAT3, NFKB1, NOTCH1
KAT5	PTPRJ	No	-	3	VHL, UBC, CTNNB1
TLR2	TLR4	Yes	activation	33	RAC1, EGFR, IL8, HSPD1, TOLLIP, DCN, KNG1, CHUK, HSP90B1, IL6, MAP3K7, CD14, SFTPA1, LY96, HSPA9, IRAK2, TICAM1, TIRAP, STAT3, TRAF6, IKBKB, TLR1, RELA, SRC, ICAM1, NFKB1, HMGB1, HSPA8, IL4, CD36, MMP9, VIP, IRF3
TLR2	PTPRJ	No	-	2	SRC, EGFR
BRAF	TLR4	No	-	3	UBC, MAP3K1, AKT1
BRAF	PTPRJ	No	-	3	UBC, MAPK1, MAPK3
TLR4	PTPRJ	No	-	3	SRC, UBC, EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
CTNNB1	EP300	Yes	TCF4-CTNNB1-EP300 complex;TCF4-CTNNB1-SUMO1-EP300-HADAC6 complex	4	CREBBP, HDAC6, TCF4, SUMO1
CTNNB1	TP53	No	-	2	AXIN1, EP300
CTNNB1	APC	Yes	AXIN-APC-betaCatenin-GSK3B complex;APC-Axin-1-beta-catenin complex	2	AXIN1, GSK3B
NRAS	BRAF	No	-	1	RAF1
TRIM28	EP300	No	-	6	SMARCC1, HDAC1, RBL2, SMARCC2, SMARCA4, SMARCB1
EP300	TP53	Yes	p300-MDM2-p53 protein complex	2	TP53, MDM2
EP300	CCND1	No	-	1	PCNA
EP300	APC	No	-	1	CTNNB1
TP53	APC	No	-	1	AXIN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CTNNB1	APC	Yes	2	APC, CTNNB1
EP300	TP53	Yes	2	EP300, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	13	APC, BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, DCC, EP300, BRAF
HTLV-I infection	hsa05166	4.59	11	APC, BAX, AKT1, NRAS, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, KAT5, EP300
Colorectal cancer	hsa05210	6.52	10	APC, BAX, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, DCC, BRAF
Proteoglycans in cancer	hsa05205	5.02	9	AKT1, NRAS, CCND1, TP53, PIK3CA, CTNNB1, TLR4, BRAF, TLR2
Endometrial cancer	hsa05213	6.81	9	APC, AKT1, NRAS, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, BRAF
Hepatitis B	hsa05161	5.52	9	BAX, NRAS, CCND1, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
Prostate cancer	hsa05215	6.11	8	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300, BRAF
PI3K-Akt signaling pathway	hsa04151	4.21	8	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, TLR4, TLR2
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	7	APC, CTNNB1, NRAS, PIK3CA, FGFR3, AXIN2, AKT1
Thyroid hormone signaling pathway	hsa04919	5.82	7	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300
MicroRNAs in cancer	hsa05206	5.38	7	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, EP300
Melanoma	hsa05218	6.56	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Renal cell carcinoma	hsa05211	6.6	6	NRAS, BRAF, PIK3CA, AKT1, EP300, FLCN
Glioma	hsa05214	6.66	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Rap1 signaling pathway	hsa04015	4.97	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
Neurotrophin signaling pathway	hsa04722	5.78	6	BAX, NRAS, BRAF, PIK3CA, TP53, AKT1
Non-small cell lung cancer	hsa05223	6.88	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Viral carcinogenesis	hsa05203	5.08	6	BAX, NRAS, CCND1, PIK3CA, TP53, EP300
FoxO signaling pathway	hsa04068	5.63	6	NRAS, CCND1, PIK3CA, AKT1, EP300, BRAF
Chronic myeloid leukemia	hsa05220	6.48	6	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Wnt signaling pathway	hsa04310	5.49	6	APC, CCND1, TP53, AXIN2, CTNNB1, EP300
Measles	hsa05162	5.6	6	CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Bladder cancer	hsa05219	7.38	5	FGFR3, CCND1, NRAS, TP53, BRAF
Focal adhesion	hsa04510	4.92	5	CCND1, PIK3CA, CTNNB1, AKT1, BRAF
Pancreatic cancer	hsa05212	6.56	5	CCND1, AKT1, TP53, PIK3CA, BRAF
MAPK signaling pathway	hsa04010	4.63	5	FGFR3, BRAF, AKT1, NRAS, TP53
Thyroid cancer	hsa05216	7.48	5	CCND1, NRAS, CTNNB1, TP53, BRAF
Ras signaling pathway	hsa04014	4.9	5	FGFR3, PLA2G2A, NRAS, AKT1, PIK3CA
Central carbon metabolism in cancer	hsa05230	6.7	5	FGFR3, TP53, AKT1, NRAS, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	5	CCND1, PIK3CA, NRAS, AKT1, BRAF
Tuberculosis	hsa05152	5.17	5	BAX, EP300, AKT1, TLR2, TLR4
Hepatitis C	hsa05160	5.68	5	BRAF, NRAS, AKT1, TP53, PIK3CA
Regulation of actin cytoskeleton	hsa04810	4.9	5	APC, FGFR3, BRAF, NRAS, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	4	CCND1, NRAS, AKT1, PIK3CA
Small cell lung cancer	hsa05222	6.17	4	CCND1, TP53, AKT1, PIK3CA
Cell cycle	hsa04110	5.68	4	BUB1B, CCND1, EP300, TP53
Toll-like receptor signaling pathway	hsa04620	6.0	4	PIK3CA, AKT1, TLR2, TLR4
Basal cell carcinoma	hsa05217	6.79	4	APC, AXIN2, TP53, CTNNB1
cAMP signaling pathway	hsa04024	5.05	4	BRAF, EP300, PIK3CA, AKT1
Jak-STAT signaling pathway	hsa04630	5.44	4	CCND1, EP300, AKT1, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	4	AKT1, PIK3CA, TLR2, TLR4
HIF-1 signaling pathway	hsa04066	5.9	4	AKT1, EP300, TLR4, PIK3CA
Insulin signaling pathway	hsa04910	5.55	4	BRAF, NRAS, AKT1, PIK3CA
Hippo signaling pathway	hsa04390	5.37	4	APC, CCND1, AXIN2, CTNNB1
Epstein-Barr virus infection	hsa05169	4.97	4	AKT1, EP300, TP53, PIK3CA
Toxoplasmosis	hsa05145	5.71	4	PIK3CA, AKT1, TLR2, TLR4
Influenza A	hsa05164	5.21	4	AKT1, EP300, TLR4, PIK3CA
Apoptosis	hsa04210	6.23	4	BAX, TP53, AKT1, PIK3CA
Huntington's disease	hsa05016	5.17	4	MT-CO1, EP300, BAX, TP53
Chemokine signaling pathway	hsa04062	5.19	4	BRAF, AKT1, NRAS, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	4	MT-CO1, AKT1, BAX, PIK3CA
ErbB signaling pathway	hsa04012	6.15	4	BRAF, NRAS, AKT1, PIK3CA
Melanogenesis	hsa04916	5.97	3	EP300, NRAS, CTNNB1
T cell receptor signaling pathway	hsa04660	6.01	3	AKT1, NRAS, PIK3CA
Amoebiasis	hsa05146	5.82	3	PIK3CA, TLR2, TLR4
Fc epsilon RI signaling pathway	hsa04664	6.6	3	AKT1, NRAS, PIK3CA
VEGF signaling pathway	hsa04370	6.77	3	NRAS, AKT1, PIK3CA
Natural killer cell mediated cytotoxicity	hsa04650	5.53	3	BRAF, NRAS, PIK3CA
Metabolic pathways	hsa01100	2.49	3	ODC1, PLA2G2A, MT-CO1
p53 signaling pathway	hsa04115	6.56	3	CCND1, BAX, TP53
Tight junction	hsa04530	5.53	3	NRAS, AKT1, CTNNB1
Long-term potentiation	hsa04720	6.64	3	BRAF, EP300, NRAS
B cell receptor signaling pathway	hsa04662	6.52	3	AKT1, NRAS, PIK3CA
Adherens junction	hsa04520	6.26	3	PTPRJ, EP300, CTNNB1
Herpes simplex infection	hsa05168	5.08	3	EP300, TP53, TLR2
Oxytocin signaling pathway	hsa04921	5.4	3	CCND1, NRAS, PIK3CA
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	BRAF, AKT1, PIK3CA
Estrogen signaling pathway	hsa04915	6.11	3	NRAS, AKT1, PIK3CA
Cholinergic synapse	hsa04725	5.88	3	AKT1, NRAS, PIK3CA
AMPK signaling pathway	hsa04152	5.8	3	CCND1, AKT1, PIK3CA
mTOR signaling pathway	hsa04150	6.72	3	BRAF, AKT1, PIK3CA
Choline metabolism in cancer	hsa05231	6.09	3	NRAS, AKT1, PIK3CA
Pathogenic Escherichia coli infection	hsa05130	6.99	2	TLR4, CTNNB1
Platelet activation	hsa04611	5.66	2	PIK3CA, AKT1
Legionellosis	hsa05134	6.88	2	TLR4, TLR2
cGMP-PKG signaling pathway	hsa04022	5.32	2	AKT1, PIK3CA
Osteoclast differentiation	hsa04380	5.64	2	PIK3CA, AKT1
Leukocyte transendothelial migration	hsa04670	5.74	2	PIK3CA, CTNNB1
Phagosome	hsa04145	5.27	2	TLR4, TLR2
Serotonergic synapse	hsa04726	5.84	2	BRAF, NRAS
Leishmaniasis	hsa05140	6.32	2	TLR4, TLR2
Malaria	hsa05144	7.15	2	TLR4, TLR2
Vascular smooth muscle contraction	hsa04270	5.74	2	PLA2G2A, BRAF
Bacterial invasion of epithelial cells	hsa05100	6.34	2	PIK3CA, CTNNB1
Rheumatoid arthritis	hsa05323	6.05	2	TLR4, TLR2
Inflammatory bowel disease (IBD)	hsa05321	6.43	2	TLR4, TLR2
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	PIK3CA, AKT1
TNF signaling pathway	hsa04668	5.96	2	PIK3CA, AKT1
Long-term depression	hsa04730	6.74	2	BRAF, NRAS
Carbohydrate digestion and absorption	hsa04973	7.28	2	PIK3CA, AKT1
Alcoholism	hsa05034	5.59	2	BRAF, NRAS
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01	2	BAX, TP53
Axon guidance	hsa04360	5.63	2	DCC, NRAS
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	AKT1, PIK3CA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Epstein-Barr virus infection (hsa05169)	-	4.97	0.024	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
Influenza A (hsa05164)	-	5.21	0.001	BAX, AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, TLR2
HTLV-I infection (hsa05166)	-	4.59	0.0	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, PIK3CA, AXIN2, TP53, CTNNB1, KAT5, EP300, TLR4
Hepatitis C (hsa05160)	-	5.68	0.017	CTNNB1, NRAS, BRAF, TP53, PTPRJ, PIK3CA, AKT1, TLR2
Hepatitis B (hsa05161)	-	5.52	0.0	BAX, NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, TLR4, EP300, TLR2
Measles (hsa05162)	-	5.6	0.002	BAX, CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Vascular smooth muscle contraction (hsa04270)	-	5.74	0.003	PLA2G2A, PIK3CA, TP53, AKT1, DCC, BRAF, DLC1
Insulin signaling pathway (hsa04910)	-	5.55	0.01	NRAS, BRAF, PIK3CA, TP53, AKT1, EP300, TLR2
Ras signaling pathway (hsa04014)	-	4.9	0.0	BAX, NRAS, PLA2G2A, AURKA, TP53, BRAF, FGFR3, PIK3CA, AKT1, CCND1, TLR2
Hippo signaling pathway (hsa04390)	-	5.37	0.0	APC, BAX, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, EP300, DLC1
Prolactin signaling pathway (hsa04917)	-	6.6	0.001	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.038	TP53, AKT1, PIK3CA, CTNNB1, BRAF
MAPK signaling pathway (hsa04010)	-	4.63	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, BRAF, TLR2
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.001	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, EP300
AMPK signaling pathway (hsa04152)	-	5.8	0.014	CCND1, PIK3CA, TP53, AKT1, EP300, TLR4
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.006	AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
Human Diseases	NEW	1.54	0.003	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, TLR4, ODC1, BRAF
Cellular Processes	NEW	2.22	0.0	AKT1, BUB1B, TP53, RAD54B, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Environmental Information Processing	NEW	1.71	0.023	MT-CO1, AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.001	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.0	APC, AKT1, NRAS, CCND1, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1
cGMP-PKG signaling pathway (hsa04022)	-	5.32	0.024	BAX, PIK3CA, TP53, AKT1, KAT5, EP300, TLR4
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.03	NRAS, BRAF, PIK3CA, TP53, AKT1, EP300
Osteoclast differentiation (hsa04380)	-	5.64	0.006	CTNNB1, TP53, TLR2, AKT1, PIK3CA, EP300, TLR4
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.001	AKT1, TP53, TLR2, CTNNB1, PIK3CA, EP300, TLR4
Inflammatory bowel disease (IBD) (hsa05321)	-	6.43	0.014	KAT5, EP300, PIK3CA, TLR2, TLR4
Toxoplasmosis (hsa05145)	-	5.71	0.003	AKT1, CCND1, TP53, PIK3CA, CTNNB1, TLR4, TLR2
Wnt signaling pathway (hsa04310)	-	5.49	0.002	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, EP300
Cancers: Overview	NEW	2.72	0.001	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, TRIM28, FGFR3, ODC1, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Cancers: Specific types	NEW	4.1	0.0	APC, BAX, TLR2, CTNNB1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, AKT1, TLR4, DCC, EP300, BRAF, FLCN
Endocrine and metabolic diseases	NEW	4.75	0.002	MT-CO1, AKT1, CCND1, BAX, TP53, PTPRJ, PIK3CA, CTNNB1, EP300, TLR2
Infectious diseases: Bacterial	NEW	3.76	0.012	APC, BAX, AKT1, CCND1, DLC1, TP53, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, TLR2
Substance dependence	NEW	4.77	0.008	AKT1, NRAS, CCND1, BUB1B, PIK3CA, CTNNB1, DCC, KAT5, BRAF
Infectious diseases: Viral	NEW	3.29	0.001	APC, BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, TP53, AXIN2, PIK3CA, CTNNB1, TLR4, KAT5, EP300, BRAF, TLR2
Infectious diseases: Parasitic	NEW	4.46	0.002	BAX, AKT1, CCND1, AURKA, TP53, PIK3CA, CTNNB1, TLR4, KAT5, EP300, TLR2
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.006	CTNNB1, TP53, TLR2, AKT1, PIK3CA, TLR4
NOD-like receptor signaling pathway (hsa04621)	NEW	6.88	0.005	TP53, CTNNB1, AURKA, AKT1, TLR2
RIG-I-like receptor signaling pathway (hsa04622)	NEW	6.62	0.006	TP53, CCND1, AKT1, CTNNB1, TLR2
Axon guidance (hsa04360)	-	5.63	0.038	NRAS, CCND1, TP53, AKT1, DCC, EP300
Tuberculosis (hsa05152)	-	5.17	0.013	BAX, CTNNB1, TP53, PIK3CA, AKT1, TLR4, EP300, TLR2
Salmonella infection (hsa05132)	NEW	6.29	0.007	CTNNB1, TP53, TLR2, AKT1, PIK3CA, TLR4
Legionellosis (hsa05134)	-	6.88	0.0	CCND1, PIK3CA, TLR4, AKT1, EP300, TLR2
Jak-STAT signaling pathway (hsa04630)	-	5.44	0.034	CCND1, PIK3CA, AKT1, KAT5, EP300, TLR4
Nervous system	NEW	3.77	0.0	APC, BAX, TLR2, AKT1, NRAS, PLA2G2A, TP53, BRAF, FGFR3, PIK3CA, CTNNB1, KAT5, EP300, CCND1, TLR4
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.001	BAX, AKT1, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, BRAF, TLR2
Circulatory system	NEW	4.63	0.0	MT-CO1, AKT1, NRAS, PLA2G2A, TP53, PIK3CA, CTNNB1, DCC, KAT5, EP300, BRAF, DLC1
Endocrine system	NEW	3.26	0.0	PLA2G2A, MT-CO1, CTNNB1, NRAS, DLC1, CCND1, BUB1B, BAX, TP53, ODC1, AXIN2, PIK3CA, AKT1, TLR4, KAT5, EP300, BRAF, TLR2
Immune system	NEW	2.92	0.0	APC, PLA2G2A, BAX, AKT1, NRAS, PTPN12, AURKA, BRAF, KAT5, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, ODC1, EP300, CCND1, TLR2
Cellular community	NEW	3.57	0.0	APC, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, PTPRJ, KAT5, EP300, BRAF, TLR2
Development	NEW	4.58	0.0	AKT1, NRAS, CCND1, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, EP300, TLR2
Signal transduction	NEW	2.06	0.001	MT-CO1, AKT1, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, PLA2G2A, AXIN2, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Signaling molecules and interaction	NEW	3.09	0.048	BAX, AKT1, DLC1, CCND1, AURKA, TP53, PTPRJ, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, TLR2
Inflammatory mediator regulation of TRP channels (hsa04750)	NEW	6.07	0.01	BAX, CTNNB1, PLA2G2A, TP53, PIK3CA, AKT1
Small cell lung cancer (hsa05222)	-	6.17	0.0	AKT1, CCND1, AURKA, PIK3CA, TP53, CTNNB1, TLR4
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	AKT1, NRAS, CCND1, PIK3CA, CTNNB1, EP300, BRAF, TLR4
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300, BRAF
Cell motility	NEW	4.9	0.0	APC, BAX, CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, TLR2
Cell growth and death	NEW	4.41	0.002	BAX, AKT1, AURKA, CCND1, BUB1B, PIK3CA, TP53, TRIM28, CTNNB1, KAT5, EP300, ODC1, TLR4
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.0	APC, BAX, CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, TLR2
Alcoholism (hsa05034)	-	5.59	0.001	AKT1, NRAS, BRAF, BUB1B, PIK3CA, CTNNB1, DCC, KAT5
Melanoma (hsa05218)	-	6.56	0.0	NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Bladder cancer (hsa05219)	-	7.38	0.0	NRAS, CCND1, TP53, FGFR3, AKT1, BRAF
FoxO signaling pathway (hsa04068)	-	5.63	0.0	AKT1, NRAS, CCND1, PIK3CA, TP53, CTNNB1, KAT5, EP300, BRAF
Pancreatic cancer (hsa05212)	-	6.56	0.001	BAX, CCND1, AURKA, PIK3CA, TP53, AKT1, BRAF
Endometrial cancer (hsa05213)	-	6.81	0.0	APC, AKT1, NRAS, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, EP300, BRAF
Colorectal cancer (hsa05210)	-	6.52	0.0	APC, BAX, AKT1, CCND1, PIK3CA, AXIN2, TP53, CTNNB1, DCC, BRAF
Renal cell carcinoma (hsa05211)	-	6.6	0.0	NRAS, CCND1, PIK3CA, AKT1, EP300, BRAF, FLCN
Thyroid cancer (hsa05216)	-	7.48	0.0	NRAS, CCND1, TP53, CTNNB1, EP300, BRAF
Basal cell carcinoma (hsa05217)	-	6.79	0.011	APC, AXIN2, TP53, CTNNB1
Glioma (hsa05214)	-	6.66	0.0	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
Prostate cancer (hsa05215)	-	6.11	0.0	CTNNB1, NRAS, CCND1, AURKA, PIK3CA, TP53, AKT1, EP300, BRAF
Focal adhesion (hsa04510)	-	4.92	0.01	CTNNB1, CCND1, AURKA, PIK3CA, TP53, AKT1, KAT5, BRAF
NF-kappa B signaling pathway (hsa04064)	NEW	6.21	0.003	BAX, CCND1, TP53, TLR4, AKT1, TLR2
Chemokine signaling pathway (hsa04062)	-	5.19	0.03	NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF, TLR4
Apoptosis (hsa04210)	-	6.23	0.002	BAX, AURKA, PIK3CA, TP53, AKT1, ODC1
VEGF signaling pathway (hsa04370)	-	6.77	0.002	AKT1, PLA2G2A, EP300, NRAS, PIK3CA
Proteoglycans in cancer (hsa05205)	-	5.02	0.0	AKT1, NRAS, CCND1, TP53, PIK3CA, CTNNB1, TLR4, EP300, BRAF, TLR2
MicroRNAs in cancer (hsa05206)	-	5.38	0.0	APC, BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, EP300
Pathways in cancer (hsa05200)	-	3.98	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, TP53, FGFR3, AXIN2, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Viral carcinogenesis (hsa05203)	-	5.08	0.012	BAX, AKT1, NRAS, CCND1, BUB1B, PIK3CA, TP53, CTNNB1, EP300, TLR4
Transcriptional misregulation in cancer (hsa05202)	NEW	5.21	0.004	BAX, CTNNB1, CCND1, TRIM28, TP53, AKT1, KAT5, EP300, TLR4
T cell receptor signaling pathway (hsa04660)	-	6.01	0.007	AKT1, NRAS, CCND1, PIK3CA, CTNNB1, TLR4
Type II diabetes mellitus (hsa04930)	NEW	7.12	0.002	AKT1, TP53, EP300, PIK3CA, TLR2
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.004	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1
Rap1 signaling pathway (hsa04015)	-	4.97	0.018	AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, BRAF
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	CTNNB1, NRAS, CCND1, PIK3CA, TP53, AKT1, BRAF
ErbB signaling pathway (hsa04012)	-	6.15	0.0	NRAS, CCND1, PIK3CA, TP53, AKT1, EP300, BRAF

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	14	APC, AKT1, NRAS, CCND1, BUB1B, PIK3CA, FGFR3, AXIN2, TP53, CTNNB1, KAT5, EP300, BRAF, DLC1
Immune System	R-HSA-168256	2.37	9	CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Innate Immune System	R-HSA-168249	3.17	9	CTNNB1, NRAS, BRAF, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Disease	R-HSA-1643685	3.33	9	APC, CTNNB1, NRAS, PIK3CA, FGFR3, TLR4, AKT1, EP300, TLR2
Cell Cycle	R-HSA-1640170	3.89	7	BUB1B, CCND1, AURKA, TP53, KAT5, EP300, MLH3
Programmed Cell Death	R-HSA-5357801	5.65	7	APC, BAX, CTNNB1, TP53, AKT1, DCC, TLR4
Developmental Biology	R-HSA-1266738	3.48	7	CTNNB1, NRAS, BRAF, FGFR3, AKT1, DCC, EP300
Apoptosis	R-HSA-109581	5.68	7	APC, BAX, CTNNB1, TP53, AKT1, DCC, TLR4
Diseases of signal transduction	R-HSA-5663202	4.89	7	APC, AKT1, NRAS, PIK3CA, FGFR3, CTNNB1, EP300
Signaling by VEGF	R-HSA-194138	4.66	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	6	AKT1, NRAS, BRAF, PIK3CA, FGFR3, CTNNB1
Signaling by Wnt	R-HSA-195721	4.79	6	APC, CTNNB1, AXIN2, AKT1, KAT5, EP300
Metabolism	R-HSA-1430728	2.34	6	MT-CO1, PLA2G2A, PIK3CA, AKT1, ODC1, EP300
TCF dependent signaling in response to WNT	R-HSA-201681	5.36	6	APC, CTNNB1, AXIN2, AKT1, KAT5, EP300
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
IGF1R signaling cascade	R-HSA-2428924	4.85	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Downstream signal transduction	R-HSA-186763	4.65	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by ERBB4	R-HSA-1236394	4.7	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by Insulin receptor	R-HSA-74752	4.73	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Insulin receptor signalling cascade	R-HSA-74751	4.85	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signalling by NGF	R-HSA-166520	4.23	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
IRS-mediated signalling	R-HSA-112399	4.87	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR4	R-HSA-5654743	4.69	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by FGFR3	R-HSA-5654741	4.69	5	FGFR3, BRAF, NRAS, PIK3CA, AKT1
Signaling by FGFR	R-HSA-190236	4.67	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by SCF-KIT	R-HSA-1433557	4.73	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by PDGF	R-HSA-186797	4.53	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
DAP12 signaling	R-HSA-2424491	4.64	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	5	FGFR3, BRAF, AKT1, NRAS, PIK3CA
Signaling by EGFR	R-HSA-177929	4.59	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by GPCR	R-HSA-372790	2.68	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR2	R-HSA-5654738	4.68	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by FGFR1	R-HSA-5654736	4.69	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
DAP12 interactions	R-HSA-2172127	4.56	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Signaling by ERBB2	R-HSA-1227986	4.66	5	FGFR3, BRAF, NRAS, AKT1, PIK3CA
Hemostasis	R-HSA-109582	3.98	5	TP53, EP300, NRAS, AKT1, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	4	FGFR3, BRAF, NRAS, PIK3CA
formation of the beta-catenin:TCF transactivating complex	R-HSA-201722	7.18	4	AXIN2, KAT5, EP300, CTNNB1
Signaling by Interleukins	R-HSA-449147	4.71	4	FGFR3, BRAF, NRAS, PIK3CA
Generic Transcription Pathway	R-HSA-212436	3.86	4	MT-CO1, TP53, AKT1, TRIM28
Gene Expression	R-HSA-74160	2.72	4	MT-CO1, TP53, AKT1, TRIM28
Interleukin receptor SHC signaling	R-HSA-912526	5.09	4	FGFR3, BRAF, NRAS, PIK3CA
Interleukin-2 signaling	R-HSA-451927	5.05	4	FGFR3, BRAF, NRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	4	FGFR3, NRAS, AKT1, PIK3CA
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	4	FGFR3, BRAF, NRAS, PIK3CA
Cell Cycle, Mitotic	R-HSA-69278	4.16	4	BUB1B, AURKA, CCND1, EP300
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	4	FGFR3, BRAF, NRAS, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	4	FGFR3, AKT1, NRAS, PIK3CA
Axon guidance	R-HSA-422475	3.93	4	DCC, FGFR3, BRAF, NRAS
Adaptive Immune System	R-HSA-1280218	3.19	4	FGFR3, AKT1, NRAS, PIK3CA
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	3	MT-CO1, AKT1, TP53
PI3K/AKT activation	R-HSA-198203	6.32	3	FGFR3, AKT1, PIK3CA
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	3	FGFR3, NRAS, PIK3CA
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	FGFR3, BRAF, NRAS
Signaling by Rho GTPases	R-HSA-194315	4.43	3	BUB1B, DLC1, CTNNB1
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	3	FGFR3, PIK3CA, AKT1
Signaling by NOTCH	R-HSA-157118	6.2	3	CCND1, EP300, TP53
Cell-Cell communication	R-HSA-1500931	5.87	3	DCC, PIK3CA, CTNNB1
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59	3	APC, AKT1, CTNNB1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	FGFR3, BRAF, NRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	FGFR3, BRAF, NRAS
MAPK family signaling cascades	R-HSA-5683057	4.89	3	FGFR3, BRAF, NRAS
PIP3 activates AKT signaling	R-HSA-1257604	6.37	3	FGFR3, PIK3CA, AKT1
PI3K Cascade	R-HSA-109704	6.68	3	FGFR3, PIK3CA, AKT1
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	3	FGFR3, PIK3CA, AKT1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	3	FGFR3, AKT1, PIK3CA
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	FGFR3, BRAF, NRAS
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	FGFR3, BRAF, NRAS
Cell Cycle Checkpoints	R-HSA-69620	5.64	3	KAT5, BUB1B, TP53
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	FGFR3, BRAF, NRAS
SOS-mediated signalling	R-HSA-112412	5.15	3	FGFR3, BRAF, NRAS
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	FGFR3, BRAF, NRAS
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	PLA2G2A, EP300, PIK3CA
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	3	MT-CO1, AKT1, TP53
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	3	FGFR3, PIK3CA, AKT1
Signaling by FGFR in disease	R-HSA-1226099	7.49	3	FGFR3, NRAS, PIK3CA
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	3	FGFR3, AKT1, PIK3CA
Signaling by Leptin	R-HSA-2586552	5.1	3	FGFR3, BRAF, NRAS
GAB1 signalosome	R-HSA-180292	6.31	3	FGFR3, AKT1, PIK3CA
Frs2-mediated activation	R-HSA-170968	5.12	3	FGFR3, BRAF, NRAS
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	FGFR3, BRAF, NRAS
Signalling to RAS	R-HSA-167044	5.08	3	FGFR3, BRAF, NRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	3	FGFR3, PIK3CA, AKT1
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.49	3	CCND1, EP300, TP53
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	FGFR3, BRAF, NRAS
Chromatin modifying enzymes	R-HSA-3247509	5.19	3	CCND1, EP300, KAT5
Prolonged ERK activation events	R-HSA-169893	5.11	3	FGFR3, BRAF, NRAS
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	FGFR3, BRAF, NRAS
Signalling to ERKs	R-HSA-187687	5.04	3	FGFR3, BRAF, NRAS
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.12	3	CCND1, EP300, TP53
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	3	FGFR3, PIK3CA, AKT1
ARMS-mediated activation	R-HSA-170984	5.12	3	FGFR3, BRAF, NRAS
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	3	FGFR3, PIK3CA, AKT1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	FGFR3, BRAF, NRAS
Chromatin organization	R-HSA-4839726	5.19	3	CCND1, EP300, KAT5
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	FGFR3, BRAF, NRAS
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73	3	BAX, TP53, AKT1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	FGFR3, BRAF, NRAS
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	PIK3CA, AKT1
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51	2	TLR4, TLR2
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11	2	TLR4, TLR2
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05	2	FGFR3, PIK3CA
MAP2K and MAPK activation	R-HSA-5674135	7.66	2	BRAF, NRAS
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	NRAS, PIK3CA
Apoptotic execution phase	R-HSA-75153	7.28	2	APC, CTNNB1
disassembly of the destruction complex and recruitment of AXIN to the membrane	R-HSA-4641262	8.03	2	APC, CTNNB1
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.34	2	TLR4, TLR2
Activated TLR4 signalling	R-HSA-166054	6.27	2	TLR4, TLR2
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.52	2	TLR4, TLR2
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	2	NRAS, PIK3CA
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88	2	EP300, TP53
binding of TCF/LEF:CTNNB1 to target gene promoters	R-HSA-4411364	10.18	2	AXIN2, CTNNB1
RAF activation	R-HSA-5673000	8.34	2	BRAF, NRAS
HATs acetylate histones	R-HSA-3214847	6.23	2	KAT5, EP300
APC/C-mediated degradation of cell cycle proteins	R-HSA-174143	6.61	2	BUB1B, AURKA
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	2	NRAS, PIK3CA
S45 mutants of beta-catenin aren't phosphorylated	R-HSA-5358751	9.08	2	APC, CTNNB1
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	2	APC, CTNNB1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	PIK3CA, AKT1
Phospholipid metabolism	R-HSA-1483257	5.83	2	PLA2G2A, PIK3CA
Beta-catenin phosphorylation cascade	R-HSA-196299	8.89	2	APC, CTNNB1
Degradation of beta-catenin by the destruction complex	R-HSA-195253	6.64	2	APC, CTNNB1
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	2	NRAS, PIK3CA
CD28 co-stimulation	R-HSA-389356	7.98	2	AKT1, PIK3CA
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	PIK3CA, AKT1
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	2	NRAS, PIK3CA
G2/M Transition	R-HSA-69275	6.06	2	AURKA, EP300
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	EP300, NRAS
T41 mutants of beta-catenin aren't phosphorylated	R-HSA-5358752	9.08	2	APC, CTNNB1
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	TLR4, TLR2
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.81	2	FGFR3, NRAS
GPCR downstream signaling	R-HSA-388396	3.07	2	PIK3CA, AKT1
Caspase activation via extrinsic apoptotic signalig pathway	R-HSA-5357769	8.34	2	DCC, TLR4
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4	2	AKT1, PIK3CA
RHO GTPase Effectors	R-HSA-195258	4.94	2	BUB1B, CTNNB1
Regulation of mitotic cell cycle	R-HSA-453276	6.61	2	BUB1B, AURKA
Activation of BH3-only proteins	R-HSA-114452	8.34	2	TP53, AKT1
Mitotic G2-G2/M phases	R-HSA-453274	6.04	2	AURKA, EP300
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94	2	EP300, CTNNB1
Diseases of Immune System	R-HSA-5260271	8.34	2	TLR4, TLR2
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	2	NRAS, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	2	NRAS, PIK3CA
Toll-Like Receptors Cascades	R-HSA-168898	5.91	2	TLR4, TLR2
Negative regulation of MAPK pathway	R-HSA-5675221	7.66	2	BRAF, NRAS
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51	2	TLR4, TLR2
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	R-HSA-3134973	10.66	2	EP300, CTNNB1
misspliced GSK3beta mutants stabilize beta-catenin	R-HSA-5339716	9.08	2	APC, CTNNB1
S33 mutants of beta-catenin aren't phosphorylated	R-HSA-5358747	9.08	2	APC, CTNNB1
S37 mutants of beta-catenin aren't phosphorylated	R-HSA-5358749	9.08	2	APC, CTNNB1
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.52	2	TLR4, TLR2
Signaling by WNT in cancer	R-HSA-4791275	7.89	2	APC, CTNNB1
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.12	2	FGFR3, BRAF
G-protein beta:gamma signalling	R-HSA-397795	7.31	2	AKT1, PIK3CA
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.59	2	EP300, NRAS
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	2	NRAS, PIK3CA
Tie2 Signaling	R-HSA-210993	8.81	2	NRAS, PIK3CA
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	TLR4, TLR2
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	R-HSA-4839743	9.08	2	APC, CTNNB1
VEGFR2 mediated vascular permeability	R-HSA-5218920	8.28	2	AKT1, CTNNB1
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	2	NRAS, PIK3CA
Cellular responses to stress	R-HSA-2262752	4.56	2	EP300, TP53
Costimulation by the CD28 family	R-HSA-388841	6.56	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
TRIF-mediated TLR3/TLR4 signaling (R-HSA-937061)	NEW	6.47	0.029	TP53, CCND1, TLR2, AKT1, TLR4
Signaling by PDGF (R-HSA-186797)	-	4.53	0.0	APC, BAX, NRAS, CCND1, PIK3CA, FGFR3, ODC1, TP53, AKT1, DCC, KAT5, EP300, BRAF, TLR4
Oxidative Stress Induced Senescence (R-HSA-2559580)	NEW	6.51	0.028	CCND1, EP300, TP53, AKT1, KAT5
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.012	FGFR3, NRAS, PIK3CA
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.0	APC, PTPN12, NRAS, CCND1, TP53, FGFR3, PIK3CA, CTNNB1, KAT5, AKT1, BRAF, TLR4
Toll Like Receptor 2 (TLR2) Cascade (R-HSA-181438)	-	6.51	0.04	TP53, CCND1, TLR2, AKT1, TLR4
Immune System (R-HSA-168256)	-	2.37	0.0	AKT1, BUB1B, TP53, KAT5, APC, BRAF, PIK3CA, PTPRJ, DLC1, CTNNB1, DCC, TLR4, BAX, NRAS, TRIM28, PTPN12, EP300, TLR2, AURKA, FGFR3, ODC1, CCND1
Signaling by Rho GTPases (R-HSA-194315)	-	4.43	0.0	APC, AKT1, AURKA, CCND1, BUB1B, PIK3CA, TP53, TRIM28, CTNNB1, DCC, KAT5, EP300, DLC1
Signaling by the B Cell Receptor (BCR) (R-HSA-983705)	-	4.62	0.0	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, EP300, TLR4
Cell-Cell communication (R-HSA-1500931)	-	5.87	0.039	AKT1, PIK3CA, TP53, CTNNB1, DCC, TLR4
FGFR1 mutant receptor activation (R-HSA-1839124)	NEW	8.12	0.007	FGFR3, AKT1, CTNNB1, PIK3CA
Programmed Cell Death (R-HSA-5357801)	-	5.65	0.0	APC, BAX, CTNNB1, CCND1, DLC1, TP53, TLR4, PTPN12, DCC, AKT1, TLR2
Extracellular matrix organization (R-HSA-1474244)	NEW	4.91	0.009	CTNNB1, PTPN12, CCND1, AURKA, TP53, PIK3CA, AKT1, KAT5, BRAF
Downstream signal transduction (R-HSA-186763)	-	4.65	0.0	APC, BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, DCC, ODC1, EP300, BRAF, TLR4
deactivation of the beta-catenin transactivating complex (R-HSA-3769402)	-	7.59	0.001	APC, TP53, EP300, AKT1, CTNNB1
Cell Cycle (R-HSA-1640170)	-	3.89	0.001	APC, DLC1, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, AKT1, KAT5, EP300, MLH3
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.003	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Adaptive Immune System (R-HSA-1280218)	-	3.19	0.002	BAX, AKT1, NRAS, DLC1, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, DCC, KAT5, EP300, BRAF, TLR4
Developmental Biology (R-HSA-1266738)	-	3.48	0.011	CTNNB1, NRAS, EP300, CCND1, AURKA, TP53, FGFR3, PTPRJ, PIK3CA, PTPN12, DCC, KAT5, AKT1, BRAF, TLR4
Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582)	NEW	6.77	0.005	CCND1, EP300, TP53, AKT1, KAT5
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.001	NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, DCC, BRAF, TLR4
Signalling by NGF (R-HSA-166520)	-	4.23	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, DCC, ODC1, EP300, BRAF, TLR4
Apoptotic cleavage of cellular proteins (R-HSA-111465)	-	7.73	0.008	APC, AKT1, CTNNB1, PTPN12
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.006	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, DCC, BRAF, TLR4
Toll Like Receptor 3 (TLR3) Cascade (R-HSA-168164)	NEW	6.47	0.029	TP53, CCND1, AKT1, TLR2, TLR4
Peptide hormone metabolism (R-HSA-2980736)	NEW	6.61	0.001	APC, BAX, AKT1, CCND1, TP53, CTNNB1, EP300
Toll-Like Receptors Cascades (R-HSA-168898)	-	5.91	0.035	CCND1, PIK3CA, TP53, AKT1, TLR4, TLR2
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.0	APC, AKT1, NRAS, PTPN12, CCND1, DLC1, TP53, FGFR3, TLR4, TRIM28, CTNNB1, PIK3CA, KAT5, EP300, BRAF, TLR2
Cell Cycle, Mitotic (R-HSA-69278)	-	4.16	0.001	APC, AURKA, CCND1, BUB1B, TP53, PTPRJ, TRIM28, AKT1, KAT5, EP300, DLC1
Disease (R-HSA-1643685)	-	3.33	0.001	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, TP53, FGFR3, PTPRJ, PIK3CA, CTNNB1, TLR4, KAT5, EP300, ODC1, TLR2
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.0	BAX, AKT1, NRAS, CCND1, PIK3CA, FGFR3, TP53, CTNNB1, EP300, TLR4
Neuronal System (R-HSA-112316)	NEW	4.82	0.005	MT-CO1, AKT1, CCND1, BAX, TP53, PIK3CA, CTNNB1, DCC, BRAF
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.031	FGFR3, NRAS, AKT1, PIK3CA
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
TCF dependent signaling in response to WNT (R-HSA-201681)	-	5.36	0.006	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300, TLR4
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.002	APC, CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF
Toll Like Receptor TLR6:TLR2 Cascade (R-HSA-168188)	-	6.56	0.031	TP53, CCND1, AKT1, TLR2, TLR4
Signaling by FGFR (R-HSA-190236)	-	4.67	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.0	APC, BAX, AKT1, NRAS, AURKA, CCND1, BUB1B, PIK3CA, FGFR3, TP53, CTNNB1, EP300
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.034	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.018	CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Innate Immune System (R-HSA-168249)	-	3.17	0.0	APC, BAX, CTNNB1, NRAS, EP300, CCND1, DLC1, TP53, FGFR3, ODC1, TLR4, PTPN12, PIK3CA, DCC, KAT5, AKT1, BRAF, TLR2
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.002	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF, TLR4
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.0	FGFR3, AKT1, NRAS, PIK3CA, CTNNB1
M Phase (R-HSA-68886)	NEW	4.87	0.048	APC, BUB1B, AURKA, TP53, PTPRJ, AKT1, KAT5
Signalling to RAS (R-HSA-167044)	-	5.08	0.002	CTNNB1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, BRAF
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (R-HSA-3134973)	-	10.66	0.03	EP300, CTNNB1
DAP12 signaling (R-HSA-2424491)	-	4.64	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.02	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MyD88-independent TLR3/TLR4 cascade (R-HSA-166166)	NEW	6.47	0.029	TP53, CCND1, TLR2, AKT1, TLR4
Signaling by EGFR (R-HSA-177929)	-	4.59	0.001	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.0	APC, BAX, AKT1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, CTNNB1, ODC1, EP300, BRAF, TLR4
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.014	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Apoptotic execution phase (R-HSA-75153)	-	7.28	0.026	APC, AKT1, PTPN12, CTNNB1
RHO GTPase Effectors (R-HSA-195258)	-	4.94	0.007	CTNNB1, AURKA, TP53, BUB1B, PIK3CA, TRIM28, AKT1, KAT5, EP300
Signaling by Wnt (R-HSA-195721)	-	4.79	0.024	APC, CTNNB1, CCND1, TP53, AXIN2, AKT1, KAT5, EP300, TLR4
formation of the beta-catenin:TCF transactivating complex (R-HSA-201722)	-	7.18	0.027	AXIN2, KAT5, EP300, CTNNB1
Signaling by GPCR (R-HSA-372790)	-	2.68	0.015	APC, BAX, AKT1, NRAS, CCND1, TP53, FGFR3, ODC1, PIK3CA, CTNNB1, TLR4, DCC, KAT5, EP300, BRAF, TLR2
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signalling to ERKs (R-HSA-187687)	-	5.04	0.0	APC, CTNNB1, NRAS, CCND1, AURKA, PIK3CA, FGFR3, TP53, AKT1, BRAF
Pre-NOTCH Transcription and Translation (R-HSA-1912408)	-	8.12	0.028	CCND1, EP300, TP53
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.013	APC, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, BRAF
Signaling by VEGF (R-HSA-194138)	-	4.66	0.003	APC, CTNNB1, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, EP300, BRAF
DAP12 interactions (R-HSA-2172127)	-	4.56	0.001	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
MyD88:Mal cascade initiated on plasma membrane (R-HSA-166058)	-	6.56	0.031	CCND1, TLR2, TP53, AKT1, TLR4
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.0	BAX, NRAS, CCND1, PIK3CA, FGFR3, TP53, AKT1, ODC1, EP300, BRAF, TLR4
Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179)	-	6.51	0.04	CCND1, TLR2, TP53, AKT1, TLR4
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.047	FGFR3, NRAS, PIK3CA
Hemostasis (R-HSA-109582)	-	3.98	0.001	APC, MT-CO1, AKT1, NRAS, AURKA, CCND1, BUB1B, TP53, PIK3CA, CTNNB1, KAT5, EP300, ODC1, TLR4
Apoptosis (R-HSA-109581)	-	5.68	0.0	APC, BAX, CTNNB1, CCND1, DLC1, TP53, TLR4, PTPN12, DCC, AKT1, TLR2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	29	MT-CO1, AKT1, BUB1B, TP53, RAD54B, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, PLA2G2A, TRIM28, AXIN2, MCC, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
protein binding (GO:0005515)	0.46	27	MT-CO1, AKT1, BUB1B, TP53, KAT5, APC, CCND1, PIK3CA, PTPRJ, TLR2, CTNNB1, DCC, FLCN, BAX, NRAS, MCC, AXIN2, TRIM28, PTPN12, EP300, DLC1, AURKA, FGFR3, TLR4, ODC1, BRAF, MLH3
catalytic activity (GO:0003824)	1.05	18	PLA2G2A, MT-CO1, PTPN12, AURKA, PDGFRL, BUB1B, TRIM28, BRAF, FGFR3, ODC1, RAD54B, PTPRJ, PIK3CA, AKT1, KAT5, EP300, CCND1, MLH3
organic cyclic compound binding (GO:0097159)	1.05	14	MT-CO1, AKT1, NRAS, AURKA, TP53, BUB1B, TRIM28, FGFR3, RAD54B, PIK3CA, CTNNB1, EP300, BRAF, MLH3
heterocyclic compound binding (GO:1901363)	1.06	14	MT-CO1, AKT1, NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, TRIM28, PIK3CA, CTNNB1, EP300, MLH3
carbohydrate derivative binding (GO:0097367)	2.03	12	TLR2, NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, TLR4, MLH3
transferase activity (GO:0016740)	1.95	11	AURKA, PDGFRL, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, KAT5, EP300, CCND1
enzyme binding (GO:0019899)	2.27	11	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, TRIM28, AKT1, PTPRJ, EP300, BRAF
small molecule binding (GO:0036094)	1.89	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
nucleotide binding (GO:0000166)	1.96	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
protein kinase binding (GO:0019901)	3.44	10	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, PTPRJ, EP300, BRAF
kinase binding (GO:0019900)	3.32	10	APC, CTNNB1, CCND1, AURKA, TP53, AXIN2, AKT1, PTPRJ, EP300, BRAF
macromolecular complex binding (GO:0044877)	2.61	10	APC, BAX, NRAS, CCND1, TRIM28, TP53, FLCN, CTNNB1, EP300, MLH3
ribonucleotide binding (GO:0032553)	2.19	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine nucleoside binding (GO:0001883)	2.22	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
ribonucleoside binding (GO:0032549)	2.22	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
purine ribonucleotide binding (GO:0032555)	2.2	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine nucleotide binding (GO:0017076)	2.19	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
purine ribonucleoside binding (GO:0032550)	2.22	10	NRAS, AURKA, BRAF, BUB1B, TP53, FGFR3, RAD54B, PIK3CA, AKT1, MLH3
nucleoside phosphate binding (GO:1901265)	1.96	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
nucleoside binding (GO:0001882)	2.21	10	NRAS, AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
adenyl nucleotide binding (GO:0030554)	2.4	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
kinase activity (GO:0016301)	2.93	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
adenyl ribonucleotide binding (GO:0032559)	2.41	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
protein kinase activity (GO:0004672)	3.27	9	AURKA, CCND1, BUB1B, PIK3CA, BRAF, FGFR3, TRIM28, AKT1, PDGFRL
ATP binding (GO:0005524)	2.43	9	AURKA, BRAF, BUB1B, PIK3CA, FGFR3, RAD54B, TP53, AKT1, MLH3
molecular function regulator (GO:0098772)	2.51	8	APC, CCND1, PIK3CA, FGFR3, AXIN2, DLC1, AKT1, FLCN
ion binding (GO:0043167)	1.36	8	MT-CO1, PLA2G2A, TRIM28, TP53, AKT1, KAT5, EP300, BRAF
protein complex binding (GO:0032403)	3.09	7	APC, BAX, NRAS, CCND1, CTNNB1, EP300, FLCN
cation binding (GO:0043169)	1.4	7	MT-CO1, PLA2G2A, TP53, TRIM28, KAT5, EP300, BRAF
metal ion binding (GO:0046872)	1.41	7	MT-CO1, PLA2G2A, TP53, TRIM28, KAT5, EP300, BRAF
signal transducer activity (GO:0004871)	2.28	7	PDGFRL, FGFR3, TLR2, CTNNB1, DCC, BRAF, TLR4
enzyme regulator activity (GO:0030234)	2.85	6	APC, CCND1, PIK3CA, AXIN2, AKT1, DLC1
lipid binding (GO:0008289)	3.26	6	BAX, PLA2G2A, TLR2, AKT1, TLR4, DLC1
molecular transducer activity (GO:0060089)	2.32	6	PDGFRL, MCC, FGFR3, TLR4, DCC, TLR2
receptor activity (GO:0004872)	2.32	6	PDGFRL, MCC, FGFR3, TLR4, DCC, TLR2
nucleic acid binding (GO:0003676)	1.44	6	TP53, RAD54B, TRIM28, CTNNB1, EP300, MLH3
DNA binding (GO:0003677)	1.92	6	TP53, RAD54B, TRIM28, CTNNB1, EP300, MLH3
receptor binding (GO:0005102)	2.43	6	TP53, PTPRJ, CTNNB1, KAT5, EP300, TLR2
hydrolase activity (GO:0016787)	1.9	5	RAD54B, PLA2G2A, PTPRJ, MLH3, PTPN12
signaling receptor activity (GO:0038023)	2.49	5	DCC, FGFR3, PDGFRL, TLR4, TLR2
transcription factor binding (GO:0008134)	3.46	5	CCND1, EP300, TP53, CTNNB1, KAT5
transcription cofactor activity (GO:0003712)	3.44	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
protein serine/threonine kinase activity (GO:0004674)	3.64	5	BUB1B, BRAF, AURKA, PIK3CA, AKT1
transmembrane signaling receptor activity (GO:0004888)	2.57	5	FGFR3, DCC, PDGFRL, TLR4, TLR2
identical protein binding (GO:0042802)	2.63	5	ODC1, BAX, TP53, AKT1, BRAF
protein domain specific binding (GO:0019904)	3.32	5	PTPN12, BAX, AXIN2, DLC1, TRIM28
transcription factor activity, transcription factor binding (GO:0000989)	3.36	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
transcription factor activity, protein binding (GO:0000988)	3.35	5	CCND1, EP300, TRIM28, CTNNB1, KAT5
protein dimerization activity (GO:0046983)	2.72	5	ODC1, BAX, TP53, TLR2, BRAF
chromatin binding (GO:0003682)	3.64	5	MLH3, TP53, EP300, TRIM28, CTNNB1
transmembrane receptor activity (GO:0099600)	2.53	5	DCC, FGFR3, PDGFRL, TLR2, TLR4
sequence-specific DNA binding (GO:0043565)	2.79	4	TP53, EP300, MLH3, TRIM28
ubiquitin protein ligase binding (GO:0031625)	4.17	4	AURKA, AXIN2, TRIM28, TP53
ubiquitin-like protein ligase binding (GO:0044389)	4.15	4	AXIN2, AURKA, TRIM28, TP53
transition metal ion binding (GO:0046914)	2.48	4	MT-CO1, EP300, TP53, TRIM28
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	4	TRIM28, EP300, TP53, CTNNB1
transcription coactivator activity (GO:0003713)	4.04	4	KAT5, EP300, TRIM28, CTNNB1
beta-catenin binding (GO:0008013)	5.3	4	APC, PTPRJ, EP300, AXIN2
nucleic acid binding transcription factor activity (GO:0001071)	2.65	4	TP53, EP300, TRIM28, CTNNB1
double-stranded DNA binding (GO:0003690)	3.09	4	TP53, EP300, MLH3, CTNNB1
protein heterodimerization activity (GO:0046982)	3.64	4	BRAF, BAX, TP53, TLR2
RNA polymerase II transcription factor binding (GO:0001085)	5.08	3	EP300, TP53, CTNNB1
transcription regulatory region DNA binding (GO:0044212)	3.03	3	EP300, TP53, CTNNB1
steroid hormone receptor binding (GO:0035258)	5.32	3	KAT5, EP300, CTNNB1
kinase regulator activity (GO:0019207)	4.5	3	APC, CCND1, PIK3CA
protein kinase regulator activity (GO:0019887)	4.6	3	APC, CCND1, PIK3CA
nuclear hormone receptor binding (GO:0035257)	4.7	3	KAT5, EP300, CTNNB1
regulatory region nucleic acid binding (GO:0001067)	3.03	3	EP300, TP53, CTNNB1
androgen receptor binding (GO:0050681)	6.07	3	KAT5, EP300, CTNNB1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PLA2G2A, PTPRJ, PTPN12
SMAD binding (GO:0046332)	5.45	3	AXIN2, EP300, CTNNB1
protein phosphatase binding (GO:0019903)	4.93	3	TP53, AKT1, CTNNB1
phosphatase binding (GO:0019902)	4.63	3	TP53, AKT1, CTNNB1
zinc ion binding (GO:0008270)	2.66	3	EP300, TP53, TRIM28
regulatory region DNA binding (GO:0000975)	3.03	3	EP300, TP53, CTNNB1
hormone receptor binding (GO:0051427)	4.57	3	KAT5, EP300, CTNNB1
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	3	EP300, MLH3, TP53
enzyme activator activity (GO:0008047)	3.56	3	AXIN2, DLC1, PIK3CA
protein C-terminus binding (GO:0008022)	4.5	2	EP300, CTNNB1
transcription corepressor activity (GO:0003714)	4.33	2	CCND1, TRIM28
phosphatase activity (GO:0016791)	4.11	2	PTPRJ, PTPN12
peptide N-acetyltransferase activity (GO:0034212)	5.55	2	KAT5, EP300
activating transcription factor binding (GO:0033613)	5.68	2	EP300, CTNNB1
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	FGFR3, FLCN
peptide-lysine-N-acetyltransferase activity (GO:0061733)	5.68	2	KAT5, EP300
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	EP300, TP53
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	PTPRJ, PTPN12
pattern recognition receptor activity (GO:0038187)	6.91	2	TLR4, TLR2
cadherin binding (GO:0045296)	6.41	2	APC, CTNNB1
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	FGFR3, PIK3CA
repressing transcription factor binding (GO:0070491)	5.71	2	KAT5, CTNNB1
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	2	FGFR3, PIK3CA
N-acetyltransferase activity (GO:0008080)	5.27	2	KAT5, EP300
phospholipid binding (GO:0005543)	3.91	2	PLA2G2A, AKT1
histone acetyltransferase activity (GO:0004402)	5.7	2	KAT5, EP300
transmembrane transporter activity (GO:0022857)	2.82	2	MT-CO1, BAX
chaperone binding (GO:0051087)	5.34	2	BAX, TP53
transporter activity (GO:0005215)	2.57	2	MT-CO1, BAX
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	2	FGFR3, PIK3CA
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	FGFR3, PDGFRL
transferase activity, transferring acyl groups (GO:0016746)	4.2	2	KAT5, EP300
protein tyrosine kinase activity (GO:0004713)	4.54	2	FGFR3, PDGFRL
N-acyltransferase activity (GO:0016410)	5.08	2	KAT5, EP300
I-SMAD binding (GO:0070411)	7.34	2	AXIN2, CTNNB1
protein serine/threonine/tyrosine kinase activity (GO:0004712)	6.07	2	AURKA, AKT1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	EP300, TP53
calcium ion binding (GO:0005509)	3.17	2	PLA2G2A, BRAF