Disease table of DIARRHEA, CHRONIC, WITH VILLOUS ATROPHY OMIM ID: 520100

Gene-disease associations table

GeneAssociated with DIARRHEA, CHRONIC, WITH VILLOUS ATROPHY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MT-CYBOMIMHGNC linkMT4550500, 500000, 520100, 535000
MT-ND4LOMIMHGNC linkMT2520100, 535000
MT-ND5OMIMHGNC linkMT6535000, 256000, 520100, 540000, 545000, 252010

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MT-CYBMT-ND4LNo-1NDUFA4
MT-CYBMT-ND5No-1NDUFA4
MT-ND4LMT-ND5Yesbinding43NDUFS8, NDUFV2, MT-ND1, MT-ND2, NDUFS5, NDUFA1, NDUFB1, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFA6, NDUFA9, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFV1, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, MT-ND4, NDUFB9, NDUFA2, NDUFS6, NDUFAF1, NDUFB3, NDUFB5, NDUFA4, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MT-ND4LMT-ND5YesRespiratory chain complex I (holoenzyme), mitochondrial42NDUFS8, NDUFV2, MT-ND1, NDUFB9, NDUFS5, NDUFA1, NDUFB1, NDUFA3, NDUFS1, NDUFA13, NDUFA7, NDUFS7, NDUFB4, NDUFS3, NDUFB7, NDUFA8, NDUFV1, NDUFA12, MT-ND3, NDUFA5, NDUFAB1, NDUFA11, MT-ND6, NDUFB11, NDUFB6, NDUFB8, NDUFA6, NDUFA10, NDUFS2, NDUFB10, NDUFC1, NDUFB2, NDUFS4, NDUFA4, MT-ND2, NDUFA2, NDUFS6, NDUFB3, NDUFB5, NDUFA9, NDUFV3, NDUFC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493MT-ND4L, MT-ND5, MT-CYB
Parkinson's diseasehsa050125.593MT-ND4L, MT-ND5, MT-CYB
Oxidative phosphorylationhsa001905.693MT-ND4L, MT-ND5, MT-CYB

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.002MT-ND4L, MT-ND5, MT-CYB
Energy metabolismNEW5.420.0MT-ND4L, MT-ND5, MT-CYB
Parkinson's disease (hsa05012) -5.590.0MT-ND4L, MT-ND5, MT-CYB
Oxidative phosphorylation (hsa00190) -5.690.0MT-ND4L, MT-ND5, MT-CYB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.123MT-ND4L, MT-ND5, MT-CYB
Respiratory electron transportR-HSA-6111056.443MT-ND4L, MT-ND5, MT-CYB
MetabolismR-HSA-14307282.343MT-ND4L, MT-ND5, MT-CYB
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.713MT-ND4L, MT-ND5, MT-CYB

NET-GE enrichment

Term New enriched termICP valueGenes
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0MT-ND4L, MT-ND5, MT-CYB
Respiratory electron transport (R-HSA-611105) -6.440.0MT-ND4L, MT-ND5, MT-CYB
Metabolism (R-HSA-1430728) -2.340.039MT-ND4L, MT-ND5, MT-CYB
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0MT-ND4L, MT-ND5, MT-CYB
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053MT-ND4L, MT-ND5, MT-CYB
oxidoreductase activity (GO:0016491) 3.123MT-ND4L, MT-ND5, MT-CYB
NADH dehydrogenase (ubiquinone) activity (GO:0008137) 5.932MT-ND4L, MT-ND5
oxidoreductase activity, acting on NAD(P)H (GO:0016651) 5.132MT-ND4L, MT-ND5
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) 5.662MT-ND4L, MT-ND5
NADH dehydrogenase activity (GO:0003954) 5.932MT-ND4L, MT-ND5
NADH dehydrogenase (quinone) activity (GO:0050136) 5.932MT-ND4L, MT-ND5

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity (GO:0016491) -3.120.002MT-ND4L, MT-ND5, MT-CYB
NADH dehydrogenase (ubiquinone) activity (GO:0008137) -5.930.001MT-ND4L, MT-ND5
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) -5.660.001MT-ND4L, MT-ND5
oxidoreductase activity, acting on NAD(P)H (GO:0016651) -5.130.016MT-ND4L, MT-ND5
NADH dehydrogenase activity (GO:0003954) -5.930.001MT-ND4L, MT-ND5
NADH dehydrogenase (quinone) activity (GO:0050136) -5.930.001MT-ND4L, MT-ND5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism metabolic process (GO:0044710) 1.633MT-ND4L, MT-ND5, MT-CYB
cellular process (GO:0009987) 0.263MT-ND4L, MT-ND5, MT-CYB
cellular metabolic process (GO:0044237) 0.693MT-ND4L, MT-ND5, MT-CYB
electron transport chain (GO:0022900) 5.093MT-ND4L, MT-ND5, MT-CYB
single-organism cellular process (GO:0044763) 0.653MT-ND4L, MT-ND5, MT-CYB
oxidation-reduction process (GO:0055114) 2.913MT-ND4L, MT-ND5, MT-CYB
metabolic process (GO:0008152) 0.583MT-ND4L, MT-ND5, MT-CYB
respiratory electron transport chain (GO:0022904) 5.113MT-ND4L, MT-ND5, MT-CYB
generation of precursor metabolites and energy (GO:0006091) 4.073MT-ND4L, MT-ND5, MT-CYB
single-organism process (GO:0044699) 0.483MT-ND4L, MT-ND5, MT-CYB
response to endogenous stimulus (GO:0009719) 2.792MT-ND5, MT-CYB
response to oxygen-containing compound (GO:1901700) 2.572MT-ND5, MT-CYB
response to stimulus (GO:0050896) 1.222MT-ND5, MT-CYB
response to hypoxia (GO:0001666) 4.132MT-ND5, MT-CYB
response to abiotic stimulus (GO:0009628) 2.82MT-ND5, MT-CYB
response to decreased oxygen levels (GO:0036293) 4.092MT-ND5, MT-CYB
response to organonitrogen compound (GO:0010243) 3.22MT-ND5, MT-CYB
response to nitrogen compound (GO:1901698) 3.122MT-ND5, MT-CYB
mitochondrial electron transport, NADH to ubiquinone (GO:0006120) 5.842MT-ND4L, MT-ND5
response to stress (GO:0006950) 1.82MT-ND5, MT-CYB
response to chemical (GO:0042221) 1.982MT-ND5, MT-CYB
response to inorganic substance (GO:0010035) 3.562MT-ND5, MT-CYB
ATP synthesis coupled electron transport (GO:0042773) 7.652MT-ND4L, MT-ND5
response to organic substance (GO:0010033) 2.22MT-ND5, MT-CYB
response to oxygen levels (GO:0070482) 4.022MT-ND5, MT-CYB

NET-GE enrichment

Term New enriched termICP valueGenes
mitochondrial electron transport, NADH to ubiquinone (GO:0006120) -5.840.001MT-ND4L, MT-ND5
electron transport chain (GO:0022900) -5.090.0MT-ND4L, MT-ND5, MT-CYB
respiratory electron transport chain (GO:0022904) -5.110.0MT-ND4L, MT-ND5, MT-CYB
generation of precursor metabolites and energy (GO:0006091) -4.070.021MT-ND4L, MT-ND5, MT-CYB
oxidation-reduction process (GO:0055114) -2.910.006MT-ND4L, MT-ND5, MT-CYB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
oxidoreductase complex (GO:1990204) 5.193MT-ND4L, MT-ND5, MT-CYB
intracellular organelle (GO:0043229) 0.513MT-ND4L, MT-ND5, MT-CYB
membrane-bounded organelle (GO:0043227) 0.473MT-ND4L, MT-ND5, MT-CYB
organelle (GO:0043226) 0.43MT-ND4L, MT-ND5, MT-CYB
intrinsic component of membrane (GO:0031224) 1.133MT-ND4L, MT-ND5, MT-CYB
organelle membrane (GO:0031090) 1.973MT-ND4L, MT-ND5, MT-CYB
integral component of membrane (GO:0016021) 1.143MT-ND4L, MT-ND5, MT-CYB
membrane (GO:0016020) 0.683MT-ND4L, MT-ND5, MT-CYB
respiratory chain complex (GO:0098803) 5.473MT-ND4L, MT-ND5, MT-CYB
mitochondrion (GO:0005739) 2.423MT-ND4L, MT-ND5, MT-CYB
inner mitochondrial membrane protein complex (GO:0098800) 5.013MT-ND4L, MT-ND5, MT-CYB
mitochondrial membrane part (GO:0044455) 4.543MT-ND4L, MT-ND5, MT-CYB
catalytic complex (GO:1902494) 2.93MT-ND4L, MT-ND5, MT-CYB
mitochondrial membrane (GO:0031966) 3.313MT-ND4L, MT-ND5, MT-CYB
protein complex (GO:0043234) 1.513MT-ND4L, MT-ND5, MT-CYB
macromolecular complex (GO:0032991) 1.353MT-ND4L, MT-ND5, MT-CYB
intracellular membrane-bounded organelle (GO:0043231) 0.63MT-ND4L, MT-ND5, MT-CYB
cell part (GO:0044464) 0.113MT-ND4L, MT-ND5, MT-CYB
intracellular organelle part (GO:0044446) 0.813MT-ND4L, MT-ND5, MT-CYB
membrane protein complex (GO:0098796) 2.843MT-ND4L, MT-ND5, MT-CYB
cytoplasmic part (GO:0044444) 0.823MT-ND4L, MT-ND5, MT-CYB
mitochondrial part (GO:0044429) 2.923MT-ND4L, MT-ND5, MT-CYB
intracellular part (GO:0044424) 0.283MT-ND4L, MT-ND5, MT-CYB
membrane part (GO:0044425) 0.953MT-ND4L, MT-ND5, MT-CYB
respiratory chain (GO:0070469) 5.513MT-ND4L, MT-ND5, MT-CYB
organelle part (GO:0044422) 0.793MT-ND4L, MT-ND5, MT-CYB
mitochondrial protein complex (GO:0098798) 4.783MT-ND4L, MT-ND5, MT-CYB
mitochondrial inner membrane (GO:0005743) 3.652MT-ND5, MT-CYB
NADH dehydrogenase complex (GO:0030964) 5.912MT-ND4L, MT-ND5
respiratory chain complex I (GO:0045271) 5.912MT-ND4L, MT-ND5
organelle inner membrane (GO:0019866) 3.562MT-ND5, MT-CYB
mitochondrial respiratory chain complex I (GO:0005747) 5.912MT-ND4L, MT-ND5

NET-GE enrichment

Term New enriched termICP valueGenes
respiratory chain complex I (GO:0045271) -5.910.001MT-ND4L, MT-ND5
catalytic complex (GO:1902494) -2.90.002MT-ND4L, MT-ND5, MT-CYB
NADH dehydrogenase complex (GO:0030964) -5.910.001MT-ND4L, MT-ND5
organelle inner membrane (GO:0019866) -3.560.0MT-ND4L, MT-ND5, MT-CYB
mitochondrial membrane (GO:0031966) -3.310.001MT-ND4L, MT-ND5, MT-CYB
mitochondrial membrane part (GO:0044455) -4.540.0MT-ND4L, MT-ND5, MT-CYB
mitochondrial respiratory chain complex I (GO:0005747) -5.910.001MT-ND4L, MT-ND5
mitochondrial inner membrane (GO:0005743) -3.650.0MT-ND4L, MT-ND5, MT-CYB
oxidoreductase complex (GO:1990204) -5.190.0MT-ND4L, MT-ND5, MT-CYB
mitochondrial part (GO:0044429) -2.920.034MT-ND4L, MT-ND5, MT-CYB