Disease table of TREMOR, HEREDITARY ESSENTIAL OMIM ID: PS190300

Gene-disease associations table

Gene	Associated with TREMOR, HEREDITARY ESSENTIAL in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TENM4	ClinVar, OMIM	HGNC link	11q14.1	1	PS190300
DRD3	OMIM	HGNC link	3q13.31	2	PS190300, 181500
FUS	ClinVar, OMIM, HUMSAVAR	HGNC link	16p11.2	2	PS190300, PS105400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
FUS	YES	3	DDIT3, CXCL8, MDM2	0

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
FUS	YES	1	TBP	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TENM4	FUS	No	1	CAND1
DRD3	FUS	No	1	GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)

REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	3	FUS, DRD3, TENM4
protein binding (GO:0005515)	0.46	3	FUS, DRD3, TENM4
organic cyclic compound binding (GO:0097159)	1.05	2	FUS, DRD3
receptor binding (GO:0005102)	2.43	2	FUS, DRD3
identical protein binding (GO:0042802)	2.63	2	FUS, TENM4

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	3	FUS, DRD3, TENM4
regulation of cellular process (GO:0050794)	0.5	3	FUS, DRD3, TENM4
organic substance metabolic process (GO:0071704)	0.63	3	FUS, DRD3, TENM4
biological regulation (GO:0065007)	0.39	3	FUS, DRD3, TENM4
metabolic process (GO:0008152)	0.58	3	FUS, DRD3, TENM4
macromolecule metabolic process (GO:0043170)	0.83	3	FUS, DRD3, TENM4
regulation of biological process (GO:0050789)	0.45	3	FUS, DRD3, TENM4
regulation of primary metabolic process (GO:0080090)	1.08	2	FUS, DRD3
regulation of metabolic process (GO:0019222)	1.02	2	FUS, DRD3
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	FUS, DRD3
regulation of cellular metabolic process (GO:0031323)	1.07	2	FUS, DRD3
nitrogen compound metabolic process (GO:0006807)	1.13	2	FUS, DRD3
signal transduction (GO:0007165)	1.28	2	DRD3, TENM4
single-organism process (GO:0044699)	0.48	2	DRD3, TENM4
regulation of oligodendrocyte differentiation (GO:0048713)	6.36	2	DRD3, TENM4
regulation of neurogenesis (GO:0050767)	3.21	2	DRD3, TENM4
regulation of system process (GO:0044057)	3.53	2	DRD3, TENM4
regulation of gliogenesis (GO:0014013)	5.21	2	DRD3, TENM4
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	DRD3, TENM4
regulation of cell development (GO:0060284)	3.01	2	DRD3, TENM4
regulation of developmental process (GO:0050793)	2.1	2	DRD3, TENM4
regulation of glial cell differentiation (GO:0045685)	5.63	2	DRD3, TENM4
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	FUS, DRD3
organic cyclic compound metabolic process (GO:1901360)	1.26	2	FUS, DRD3
positive regulation of biological process (GO:0048518)	1.2	2	DRD3, TENM4
multicellular organismal process (GO:0032501)	1.45	2	DRD3, TENM4
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	FUS, DRD3
cellular aromatic compound metabolic process (GO:0006725)	1.3	2	FUS, DRD3
regulation of biosynthetic process (GO:0009889)	1.37	2	FUS, DRD3
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	FUS, DRD3
regulation of cell differentiation (GO:0045595)	2.42	2	DRD3, TENM4
single-organism cellular process (GO:0044763)	0.65	2	DRD3, TENM4
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	FUS, DRD3
regulation of multicellular organismal process (GO:0051239)	1.87	2	DRD3, TENM4
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	FUS, DRD3
response to chemical (GO:0042221)	1.98	2	FUS, DRD3
primary metabolic process (GO:0044238)	0.69	2	FUS, TENM4
cellular macromolecule metabolic process (GO:0044260)	0.93	2	FUS, DRD3
single-multicellular organism process (GO:0044707)	1.78	2	DRD3, TENM4
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	FUS, DRD3
response to stimulus (GO:0050896)	1.22	2	FUS, DRD3
regulation of RNA metabolic process (GO:0051252)	1.52	2	FUS, DRD3
cellular metabolic process (GO:0044237)	0.69	2	FUS, DRD3
regulation of nervous system development (GO:0051960)	3.1	2	DRD3, TENM4
regulation of multicellular organismal development (GO:2000026)	2.31	2	DRD3, TENM4
positive regulation of cellular process (GO:0048522)	1.3	2	DRD3, TENM4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of oligodendrocyte differentiation (GO:0048713)	-	6.36	0.002	DRD3, TENM4
regulation of glial cell differentiation (GO:0045685)	-	5.63	0.009	DRD3, TENM4
regulation of gliogenesis (GO:0014013)	-	5.21	0.016	DRD3, TENM4

GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	FUS, DRD3, TENM4
cell part (GO:0044464)	0.11	3	FUS, DRD3, TENM4
intracellular organelle (GO:0043229)	0.51	3	FUS, DRD3, TENM4
intracellular part (GO:0044424)	0.28	3	FUS, DRD3, TENM4
cell projection (GO:0042995)	2.47	3	FUS, DRD3, TENM4
membrane-bounded organelle (GO:0043227)	0.47	3	FUS, DRD3, TENM4
organelle (GO:0043226)	0.4	3	FUS, DRD3, TENM4
cytoplasm (GO:0005737)	1.01	2	FUS, TENM4
integral component of plasma membrane (GO:0005887)	2.57	2	DRD3, TENM4
plasma membrane part (GO:0044459)	1.95	2	DRD3, TENM4
integral component of membrane (GO:0016021)	1.14	2	DRD3, TENM4
membrane (GO:0016020)	0.68	2	DRD3, TENM4
neuron part (GO:0097458)	2.64	2	FUS, TENM4
cytoplasmic part (GO:0044444)	0.82	2	FUS, DRD3
neuron projection (GO:0043005)	3.12	2	FUS, TENM4
membrane part (GO:0044425)	0.95	2	DRD3, TENM4
intrinsic component of plasma membrane (GO:0031226)	2.53	2	DRD3, TENM4
nucleus (GO:0005634)	1.07	2	FUS, TENM4
intrinsic component of membrane (GO:0031224)	1.13	2	DRD3, TENM4