Disease table of SYSTEMIC LUPUS ERYTHEMATOSUS OMIM ID: 152700

Gene-disease associations table

GeneAssociated with SYSTEMIC LUPUS ERYTHEMATOSUS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PTPN22OMIM, HUMSAVARHGNC link1p13.23180300, 152700, 222100
CTLA4OMIMHGNC link2q33.25616100, PS212750, 140300, 601388, 152700
TREX1OMIM, HUMSAVARHGNC link3p21.314PS225750, 192315, PS610448, 152700
FCGR2BOMIMHGNC link1q23.32611162, 152700
FCGR2AOMIMHGNC link1q23.33611162, 152700, 219700
DNASE1OMIMHGNC link16p13.31152700

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 782FCGR2B, FCGR2A
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
1q23.32FCGR2B, FCGR2A
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
1q232FCGR2B, FCGR2A
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1q22FCGR2B, FCGR2A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2FCGR2B, FCGR2A
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
13FCGR2B, FCGR2A, PTPN22
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CTLA4YES3FOXP3, MSC, LEF10
FCGR2BYES2YY1, GATA40
DNASE1YES1RUNX30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTPN22CTLA4No1LCK
PTPN22FCGR2ANo1CBL
PTPN22DNASE1No1ACTA1
CTLA4FCGR2ANo1LYN
TREX1FCGR2ANo1UBQLN1
FCGR2BFCGR2AYes1PTPN11

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTPN22CTLA4Yesactivation, binding2LCK, FYN
PTPN22FCGR2BNo-1CSK
PTPN22FCGR2ANo-1FYN
CTLA4FCGR2BNo-1LYN
CTLA4FCGR2ANo-5SRC, LYN, YES1, FYN, PIK3R1
FCGR2BFCGR2ANo-2SYK, LYN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Osteoclast differentiationhsa043805.642FCGR2A, FCGR2B
Phagosomehsa041455.272FCGR2A, FCGR2B
Staphylococcus aureus infectionhsa051506.642FCGR2A, FCGR2B
Fc gamma R-mediated phagocytosishsa046666.212FCGR2A, FCGR2B
Tuberculosishsa051525.172FCGR2A, FCGR2B

NET-GE enrichment

Term New enriched termICP valueGenes
Fc gamma R-mediated phagocytosis (hsa04666) -6.210.03FCGR2A, FCGR2B
Leishmaniasis (hsa05140) NEW6.320.025FCGR2A, FCGR2B
Staphylococcus aureus infection (hsa05150) -6.640.016FCGR2A, FCGR2B
Immune systemNEW2.920.008CTLA4, TREX1, FCGR2A, FCGR2B
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.374CTLA4, TREX1, FCGR2A, FCGR2B
Innate Immune SystemR-HSA-1682493.172TREX1, FCGR2A
Adaptive Immune SystemR-HSA-12802183.192CTLA4, FCGR2B

NET-GE enrichment

Term New enriched termICP valueGenes
Immune System (R-HSA-168256) -2.370.022CTLA4, TREX1, FCGR2A, FCGR2B
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186DNASE1, TREX1, FCGR2A, PTPN22, FCGR2B, CTLA4
protein binding (GO:0005515) 0.466DNASE1, TREX1, FCGR2A, PTPN22, FCGR2B, CTLA4
protein complex binding (GO:0032403) 3.093TREX1, FCGR2A, FCGR2B
hydrolase activity (GO:0016787) 1.93PTPN22, TREX1, DNASE1
macromolecular complex binding (GO:0044877) 2.613TREX1, FCGR2A, FCGR2B
hydrolase activity, acting on ester bonds (GO:0016788) 3.13PTPN22, TREX1, DNASE1
catalytic activity (GO:0003824) 1.053PTPN22, TREX1, DNASE1
deoxyribonuclease activity (GO:0004536) 5.482DNASE1, TREX1
nuclease activity (GO:0004518) 4.332DNASE1, TREX1
IgG binding (GO:0019864) 7.342FCGR2A, FCGR2B
immunoglobulin binding (GO:0019865) 6.62FCGR2A, FCGR2B

NET-GE enrichment

Term New enriched termICP valueGenes
deoxyribonuclease activity (GO:0004536) -5.480.009DNASE1, TREX1
IgG binding (GO:0019864) -7.340.002FCGR2A, FCGR2B
immunoglobulin binding (GO:0019865) -6.60.001FCGR2A, FCGR2B
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.265CTLA4, PTPN22, TREX1, DNASE1, FCGR2B
biological regulation (GO:0065007) 0.395CTLA4, PTPN22, TREX1, FCGR2A, FCGR2B
regulation of biological process (GO:0050789) 0.455CTLA4, PTPN22, TREX1, FCGR2A, FCGR2B
regulation of immune response (GO:0050776) 2.984CTLA4, PTPN22, FCGR2A, FCGR2B
response to stimulus (GO:0050896) 1.224CTLA4, PTPN22, TREX1, FCGR2B
regulation of response to stimulus (GO:0048583) 1.544CTLA4, PTPN22, FCGR2A, FCGR2B
regulation of cellular process (GO:0050794) 0.54CTLA4, PTPN22, FCGR2A, FCGR2B
immune system process (GO:0002376) 2.294CTLA4, PTPN22, FCGR2A, FCGR2B
regulation of immune system process (GO:0002682) 2.54CTLA4, PTPN22, FCGR2A, FCGR2B
signal transduction (GO:0007165) 1.284CTLA4, PTPN22, FCGR2A, FCGR2B
primary metabolic process (GO:0044238) 0.693PTPN22, TREX1, DNASE1
cellular response to stimulus (GO:0051716) 1.973CTLA4, PTPN22, TREX1
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.063CTLA4, PTPN22, FCGR2A
immune response-regulating signaling pathway (GO:0002764) 3.723CTLA4, PTPN22, FCGR2A
cellular macromolecule metabolic process (GO:0044260) 0.933PTPN22, TREX1, DNASE1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.963CTLA4, PTPN22, FCGR2A
positive regulation of response to stimulus (GO:0048584) 2.183CTLA4, PTPN22, FCGR2A
positive regulation of immune response (GO:0050778) 3.43CTLA4, PTPN22, FCGR2A
cellular metabolic process (GO:0044237) 0.693PTPN22, TREX1, DNASE1
macromolecule metabolic process (GO:0043170) 0.833PTPN22, TREX1, DNASE1
regulation of multicellular organismal process (GO:0051239) 1.873CTLA4, PTPN22, TREX1
organic substance metabolic process (GO:0071704) 0.633PTPN22, TREX1, DNASE1
positive regulation of immune system process (GO:0002684) 2.963CTLA4, PTPN22, FCGR2A
immune response-activating signal transduction (GO:0002757) 3.83CTLA4, PTPN22, FCGR2A
cell surface receptor signaling pathway (GO:0007166) 2.093CTLA4, PTPN22, FCGR2A
positive regulation of biological process (GO:0048518) 1.23CTLA4, PTPN22, FCGR2A
activation of immune response (GO:0002253) 3.673CTLA4, PTPN22, FCGR2A
metabolic process (GO:0008152) 0.583PTPN22, TREX1, DNASE1
regulation of mononuclear cell proliferation (GO:0032944) 4.452CTLA4, PTPN22
negative regulation of T cell activation (GO:0050868) 5.262CTLA4, PTPN22
regulation of cell activation (GO:0050865) 3.532CTLA4, PTPN22
positive regulation of cell activation (GO:0050867) 3.972CTLA4, PTPN22
negative regulation of cell activation (GO:0050866) 4.672CTLA4, PTPN22
regulation of T cell activation (GO:0050863) 4.052CTLA4, PTPN22
nucleic acid metabolic process (GO:0090304) 1.462DNASE1, TREX1
regulation of cell-cell adhesion (GO:0022407) 3.792CTLA4, PTPN22
negative regulation of cell adhesion (GO:0007162) 4.332CTLA4, PTPN22
nitrogen compound metabolic process (GO:0006807) 1.132DNASE1, TREX1
negative regulation of cell-cell adhesion (GO:0022408) 4.842CTLA4, PTPN22
single-organism process (GO:0044699) 0.482PTPN22, DNASE1
positive regulation of cell-cell adhesion (GO:0022409) 4.232CTLA4, PTPN22
nucleobase-containing compound metabolic process (GO:0006139) 1.352DNASE1, TREX1
regulation of lymphocyte activation (GO:0051249) 3.732CTLA4, PTPN22
positive regulation of cell adhesion (GO:0045785) 3.792CTLA4, PTPN22
organic cyclic compound metabolic process (GO:1901360) 1.262DNASE1, TREX1
negative regulation of multicellular organismal process (GO:0051241) 2.842CTLA4, PTPN22
regulation of cytokine production (GO:0001817) 3.42PTPN22, TREX1
negative regulation of leukocyte cell-cell adhesion (GO:1903038) 5.192CTLA4, PTPN22
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.352CTLA4, PTPN22
regulation of leukocyte proliferation (GO:0070663) 4.42CTLA4, PTPN22
negative regulation of immune system process (GO:0002683) 3.852CTLA4, PTPN22
negative regulation of biological process (GO:0048519) 1.332CTLA4, PTPN22
regulation of cell adhesion (GO:0030155) 3.272CTLA4, PTPN22
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.012CTLA4, PTPN22
regulation of cell proliferation (GO:0042127) 2.412CTLA4, PTPN22
antigen receptor-mediated signaling pathway (GO:0050851) 4.432CTLA4, PTPN22
cellular aromatic compound metabolic process (GO:0006725) 1.32DNASE1, TREX1
positive regulation of T cell activation (GO:0050870) 4.392CTLA4, PTPN22
cellular response to DNA damage stimulus (GO:0006974) 3.172CTLA4, TREX1
response to stress (GO:0006950) 1.82CTLA4, TREX1
single-organism cellular process (GO:0044763) 0.652PTPN22, DNASE1
immune response (GO:0006955) 2.862CTLA4, FCGR2B
heterocycle metabolic process (GO:0046483) 1.312DNASE1, TREX1
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.122DNASE1, TREX1
positive regulation of lymphocyte activation (GO:0051251) 4.072CTLA4, PTPN22
negative regulation of lymphocyte activation (GO:0051250) 4.952CTLA4, PTPN22
regulation of lymphocyte proliferation (GO:0050670) 4.462CTLA4, PTPN22
cellular nitrogen compound metabolic process (GO:0034641) 1.222DNASE1, TREX1
negative regulation of leukocyte activation (GO:0002695) 4.792CTLA4, PTPN22
regulation of leukocyte activation (GO:0002694) 3.62CTLA4, PTPN22
positive regulation of leukocyte activation (GO:0002696) 4.02CTLA4, PTPN22
cellular response to stress (GO:0033554) 2.512CTLA4, TREX1
regulation of type I interferon production (GO:0032479) 5.032PTPN22, TREX1
DNA metabolic process (GO:0006259) 3.092DNASE1, TREX1
negative regulation of cellular process (GO:0048523) 1.412CTLA4, PTPN22
positive regulation of cellular process (GO:0048522) 1.32CTLA4, PTPN22

NET-GE enrichment

Term New enriched termICP valueGenes
immune system process (GO:0002376) -2.290.012CTLA4, PTPN22, TREX1, FCGR2A, FCGR2B
regulation of immune response (GO:0050776) -2.980.017CTLA4, PTPN22, FCGR2A, FCGR2B
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.022CTLA4, PTPN22, FCGR2A
negative regulation of T cell activation (GO:0050868) -5.260.047CTLA4, PTPN22
immune response (GO:0006955) -2.860.044CTLA4, TREX1, FCGR2A, FCGR2B
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116DNASE1, TREX1, FCGR2A, PTPN22, FCGR2B, CTLA4
membrane part (GO:0044425) 0.955CTLA4, PTPN22, TREX1, FCGR2A, FCGR2B
membrane-bounded organelle (GO:0043227) 0.475CTLA4, PTPN22, TREX1, DNASE1, FCGR2A
organelle (GO:0043226) 0.45CTLA4, PTPN22, TREX1, DNASE1, FCGR2A
intracellular membrane-bounded organelle (GO:0043231) 0.64CTLA4, PTPN22, TREX1, DNASE1
integral component of membrane (GO:0016021) 1.144CTLA4, TREX1, FCGR2A, FCGR2B
membrane (GO:0016020) 0.684CTLA4, TREX1, FCGR2A, FCGR2B
intracellular organelle (GO:0043229) 0.514CTLA4, PTPN22, TREX1, DNASE1
intracellular part (GO:0044424) 0.284CTLA4, PTPN22, TREX1, DNASE1
intrinsic component of membrane (GO:0031224) 1.134CTLA4, TREX1, FCGR2A, FCGR2B
cytoplasmic part (GO:0044444) 0.823CTLA4, PTPN22, TREX1
nucleus (GO:0005634) 1.073PTPN22, TREX1, DNASE1
plasma membrane (GO:0005886) 1.393CTLA4, FCGR2A, FCGR2B
vesicle (GO:0031982) 1.643CTLA4, DNASE1, FCGR2A
membrane-bounded vesicle (GO:0031988) 1.713CTLA4, DNASE1, FCGR2A
cytoplasm (GO:0005737) 1.012PTPN22, TREX1
extracellular organelle (GO:0043230) 1.892DNASE1, FCGR2A
extracellular exosome (GO:0070062) 1.892DNASE1, FCGR2A
nuclear envelope (GO:0005635) 4.722DNASE1, TREX1
organelle envelope (GO:0031967) 4.632DNASE1, TREX1
envelope (GO:0031975) 4.622DNASE1, TREX1
intracellular organelle part (GO:0044446) 0.812DNASE1, TREX1
nuclear part (GO:0044428) 1.552DNASE1, TREX1
side of membrane (GO:0098552) 4.222CTLA4, PTPN22
perinuclear region of cytoplasm (GO:0048471) 3.352CTLA4, PTPN22
extracellular vesicle (GO:1903561) 1.892DNASE1, FCGR2A
plasma membrane part (GO:0044459) 1.952CTLA4, PTPN22
extracellular region part (GO:0044421) 1.572DNASE1, FCGR2A
organelle part (GO:0044422) 0.792DNASE1, TREX1

NET-GE enrichment

Term New enriched termICP valueGenes
nuclear envelope (GO:0005635) -4.720.032DNASE1, TREX1
organelle envelope (GO:0031967) -4.630.038DNASE1, TREX1
envelope (GO:0031975) -4.620.038DNASE1, TREX1