Disease table of NIGHT BLINDNESS, CONGENITAL STATIONARY OMIM ID: PS310500

Gene-disease associations table

GeneAssociated with NIGHT BLINDNESS, CONGENITAL STATIONARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PDE6BClinVar, OMIM, HUMSAVARHGNC link4p16.32PS310500, PS268000
NYXClinVar, OMIM, HUMSAVARHGNC linkXp11.41PS310500
LRIT3ClinVar, OMIM, HUMSAVARHGNC link4q251PS310500
SAGClinVar, OMIMHGNC link2q37.12PS310500, PS268000
CACNA1FClinVar, OMIM, HUMSAVARHGNC linkXp11.233PS310500, 300476, 300600
GRK1ClinVar, OMIM, HUMSAVARHGNC link13q341PS310500
GPR179ClinVar, OMIM, HUMSAVARHGNC link17q121PS310500
RHOClinVar, OMIM, HUMSAVARHGNC link3q22.13PS310500, 136880, PS268000
GNAT1ClinVar, OMIM, HUMSAVARHGNC link3p21.311PS310500
GRM6ClinVar, OMIM, HUMSAVARHGNC link5q35.31PS310500
SLC24A1OMIMHGNC link15q22.311PS310500
TRPM1ClinVar, OMIM, HUMSAVARHGNC link15q13.31PS310500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
Xp112NYX, CACNA1F
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
Xp12NYX, CACNA1F
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
15q2SLC24A1, TRPM1
Xp2NYX, CACNA1F
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
152SLC24A1, TRPM1
32GNAT1, RHO
42LRIT3, PDE6B
X2NYX, CACNA1F
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NRLNO4RHO, NR2E3, RBP3, PDE6B2RHO, PDE6B
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PDE6BYES3SP1, NRL, SP40
RHOYES5NRL, CRX, NR2E3, KLF15, SOX20
TRPM1YES1MITF0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SAGGRK1No1RHO
SAGRHOYes3SAG, ARRB2, RHO
GRK1RHOYes1RHO

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PDE6BRHONo-4GNAT3, GNAT2, GNGT1, GNAT1
PDE6BGNAT1Yesactivation, binding10CNGA1, CNGB1, RGS9, GNB5, GNGT1, PDE6A, GNAT3, PDE6G, RGS9BP, GNAT2
PDE6BGRM6No-1GNAT3
PDE6BSLC24A1No-1CNGA1
NYXTRPM1Yesbinding0
SAGGRK1Yesbinding1RHO
SAGRHOYesactivation, binding1GRK1
SAGGNAT1No-2RHO, OPRM1
SAGGRM6No-1OPRM1
GRK1RHOYesactivation, binding4ARRB2, ARRB1, SAG, RCVRN
GRK1GNAT1No-1RHO
GRK1GRM6No-15CXCR1, CXCR6, CCR9, CXCR3, CCR2, CCR6, CXCR2, CCR10, CCR4, CCR3, CCR5, CCR8, CXCR5, CCR7, CCR1
RHOGNAT1Yesactivation, binding7GNG2, GNGT1, OPN1SW, GNAT3, UBC, GNAT2, GNB1
RHOGRM6No-3GNAT3, GNB1, GNG2
GNAT1GRM6No-8GNG2, POMC, OPRM1, GNAI3, GNAT3, PDYN, GNAI1, GNB1
GNAT1SLC24A1No-1CNGA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Phototransductionhsa047447.915RHO, GRK1, SLC24A1, GNAT1, PDE6B

NET-GE enrichment

Term New enriched termICP valueGenes
Sensory systemNEW3.670.002RHO, GRK1, SLC24A1, GNAT1, PDE6B
Phototransduction (hsa04744) -7.910.0RHO, GRK1, SLC24A1, PDE6B, GNAT1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.787PDE6B, SAG, SLC24A1, GNAT1, RHO, GRK1, GRM6
The phototransduction cascadeR-HSA-25148568.036PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
Visual phototransductionR-HSA-21873386.446PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-25148598.085RHO, SAG, GRK1, PDE6B, GNAT1
Activation of the phototransduction cascadeR-HSA-24851799.525RHO, SAG, SLC24A1, PDE6B, GNAT1
G alpha (i) signalling eventsR-HSA-4185945.13RHO, GRM6, GNAT1
Signaling by GPCRR-HSA-3727902.683RHO, GRM6, GNAT1
GPCR downstream signalingR-HSA-3883963.073RHO, GRM6, GNAT1
GPCR ligand bindingR-HSA-5007924.192RHO, GRM6
Transmembrane transport of small moleculesR-HSA-3825513.792TRPM1, SLC24A1

NET-GE enrichment

Term New enriched termICP valueGenes
Visual phototransduction (R-HSA-2187338) -6.440.0PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
G alpha (i) signalling events (R-HSA-418594) -5.10.039RHO, GRM6, GNAT1
Activation of the phototransduction cascade (R-HSA-2485179) -9.520.0RHO, SAG, SLC24A1, GNAT1, PDE6B
The phototransduction cascade (R-HSA-2514856) -8.030.0PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
Inactivation, recovery and regulation of the phototransduction cascade (R-HSA-2514859) -8.080.0RHO, SAG, GRK1, PDE6B, GNAT1
Signal Transduction (R-HSA-162582) -1.780.033PDE6B, SAG, SLC24A1, GNAT1, RHO, GRK1, GRM6
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188PDE6B, CACNA1F, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
cation binding (GO:0043169) 1.45RHO, CACNA1F, SLC24A1, PDE6B, GNAT1
metal ion binding (GO:0046872) 1.415RHO, CACNA1F, SLC24A1, PDE6B, GNAT1
signal transducer activity (GO:0004871) 2.285RHO, GPR179, GRK1, GRM6, GNAT1
protein binding (GO:0005515) 0.465RHO, SAG, SLC24A1, GRM6, GNAT1
ion binding (GO:0043167) 1.365RHO, CACNA1F, SLC24A1, PDE6B, GNAT1
G-protein coupled receptor activity (GO:0004930) 2.954GPR179, GRK1, RHO, GRM6
signaling receptor activity (GO:0038023) 2.494GPR179, GRK1, RHO, GRM6
molecular transducer activity (GO:0060089) 2.324GPR179, GRK1, RHO, GRM6
transmembrane signaling receptor activity (GO:0004888) 2.574GPR179, GRK1, RHO, GRM6
receptor activity (GO:0004872) 2.324GPR179, GRK1, RHO, GRM6
transmembrane receptor activity (GO:0099600) 2.534GPR179, GRK1, RHO, GRM6
substrate-specific transmembrane transporter activity (GO:0022891) 2.93TRPM1, CACNA1F, SLC24A1
calcium ion transmembrane transporter activity (GO:0015085) 4.893TRPM1, CACNA1F, SLC24A1
substrate-specific transporter activity (GO:0022892) 2.723TRPM1, CACNA1F, SLC24A1
cation channel activity (GO:0005261) 4.043TRPM1, CACNA1F, SLC24A1
calcium channel activity (GO:0005262) 5.033TRPM1, CACNA1F, SLC24A1
transporter activity (GO:0005215) 2.573TRPM1, CACNA1F, SLC24A1
ion channel activity (GO:0005216) 3.713TRPM1, CACNA1F, SLC24A1
cation transmembrane transporter activity (GO:0008324) 3.323TRPM1, CACNA1F, SLC24A1
divalent inorganic cation transmembrane transporter activity (GO:0072509) 4.623TRPM1, CACNA1F, SLC24A1
ion transmembrane transporter activity (GO:0015075) 3.043TRPM1, CACNA1F, SLC24A1
catalytic activity (GO:0003824) 1.053GRK1, PDE6B, GNAT1
transmembrane transporter activity (GO:0022857) 2.823TRPM1, CACNA1F, SLC24A1
channel activity (GO:0015267) 3.63TRPM1, CACNA1F, SLC24A1
small molecule binding (GO:0036094) 1.893GRK1, RHO, GNAT1
substrate-specific channel activity (GO:0022838) 3.673TRPM1, CACNA1F, SLC24A1
passive transmembrane transporter activity (GO:0022803) 3.63TRPM1, CACNA1F, SLC24A1
metal ion transmembrane transporter activity (GO:0046873) 3.713TRPM1, CACNA1F, SLC24A1
inorganic cation transmembrane transporter activity (GO:0022890) 3.493TRPM1, CACNA1F, SLC24A1
G-protein coupled photoreceptor activity (GO:0008020) 7.342GRK1, RHO
hydrolase activity (GO:0016787) 1.92PDE6B, GNAT1
photoreceptor activity (GO:0009881) 6.972GRK1, RHO
carbohydrate derivative binding (GO:0097367) 2.032GRK1, GNAT1
organic cyclic compound binding (GO:0097159) 1.052GRK1, GNAT1
enzyme regulator activity (GO:0030234) 2.852NYX, SAG
nucleotide binding (GO:0000166) 1.962GRK1, GNAT1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222GRK1, GNAT1
purine ribonucleoside binding (GO:0032550) 2.222GRK1, GNAT1
ribonucleotide binding (GO:0032553) 2.192GRK1, GNAT1
purine nucleoside binding (GO:0001883) 2.222GRK1, GNAT1
ribonucleoside binding (GO:0032549) 2.222GRK1, GNAT1
purine ribonucleotide binding (GO:0032555) 2.22GRK1, GNAT1
purine nucleotide binding (GO:0017076) 2.192GRK1, GNAT1
enzyme inhibitor activity (GO:0004857) 3.782NYX, SAG
molecular function regulator (GO:0098772) 2.512NYX, SAG
heterocyclic compound binding (GO:1901363) 1.062GRK1, GNAT1
nucleoside phosphate binding (GO:1901265) 1.962GRK1, GNAT1
nucleoside binding (GO:0001882) 2.212GRK1, GNAT1

NET-GE enrichment

Term New enriched termICP valueGenes
calcium ion transmembrane transporter activity (GO:0015085) -4.890.037TRPM1, CACNA1F, SLC24A1
phosphatase inhibitor activity (GO:0019212) NEW6.020.002SAG, GRK1, RHO
protein phosphatase regulator activity (GO:0019888) NEW5.410.006SAG, GRK1, RHO
phosphatase regulator activity (GO:0019208) NEW5.260.011SAG, GRK1, RHO
divalent inorganic cation transmembrane transporter activity (GO:0072509) -4.620.013TRPM1, CACNA1F, SLC24A1
protein phosphatase inhibitor activity (GO:0004864) NEW6.070.002SAG, GRK1, RHO
opsin binding (GO:0002046) NEW8.350.001SAG, RHO
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
multicellular organismal process (GO:0032501) 1.4512GPR179, SAG, PDE6B, TRPM1, CACNA1F, SLC24A1, NYX, LRIT3, GRM6, RHO, GRK1, GNAT1
neurological system process (GO:0050877) 2.6412GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, LRIT3, GRM6, RHO, CACNA1F, GNAT1
visual perception (GO:0007601) 4.4112GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, LRIT3, GRM6, RHO, CACNA1F, GNAT1
sensory perception (GO:0007600) 2.9312GPR179, SAG, PDE6B, TRPM1, CACNA1F, SLC24A1, NYX, LRIT3, GRM6, RHO, GRK1, GNAT1
sensory perception of light stimulus (GO:0050953) 4.412GPR179, SAG, PDE6B, TRPM1, CACNA1F, SLC24A1, NYX, LRIT3, GRM6, RHO, GRK1, GNAT1
biological regulation (GO:0065007) 0.3912GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, LRIT3, GRM6, RHO, CACNA1F, GNAT1
system process (GO:0003008) 2.312GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, LRIT3, GRM6, RHO, CACNA1F, GNAT1
response to stimulus (GO:0050896) 1.2211GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, GRM6, RHO, CACNA1F, GNAT1
regulation of biological process (GO:0050789) 0.4511GPR179, RHO, PDE6B, TRPM1, GRK1, NYX, LRIT3, GRM6, CACNA1F, SAG, GNAT1
regulation of cellular process (GO:0050794) 0.511GPR179, SAG, PDE6B, TRPM1, CACNA1F, NYX, LRIT3, GRM6, RHO, GRK1, GNAT1
response to abiotic stimulus (GO:0009628) 2.89GRK1, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
response to radiation (GO:0009314) 3.699PDE6B, CACNA1F, SAG, SLC24A1, TRPM1, GRM6, RHO, GRK1, GNAT1
cellular process (GO:0009987) 0.269GPR179, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
response to light stimulus (GO:0009416) 4.089PDE6B, CACNA1F, SAG, SLC24A1, TRPM1, GRM6, RHO, GRK1, GNAT1
signal transduction (GO:0007165) 1.289GPR179, PDE6B, TRPM1, GRK1, NYX, GRM6, RHO, SAG, GNAT1
regulation of signaling (GO:0023051) 1.729RHO, PDE6B, GRK1, NYX, LRIT3, GRM6, CACNA1F, SAG, GNAT1
regulation of cell communication (GO:0010646) 1.739RHO, PDE6B, GRK1, NYX, LRIT3, GRM6, CACNA1F, SAG, GNAT1
regulation of signal transduction (GO:0009966) 1.848RHO, PDE6B, GRK1, NYX, LRIT3, CACNA1F, SAG, GNAT1
G-protein coupled receptor signaling pathway (GO:0007186) 2.648GPR179, PDE6B, TRPM1, GRK1, GRM6, RHO, SAG, GNAT1
regulation of response to stimulus (GO:0048583) 1.548RHO, PDE6B, GRK1, NYX, LRIT3, CACNA1F, SAG, GNAT1
single-organism process (GO:0044699) 0.488GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, GRM6, RHO, GNAT1
detection of external stimulus (GO:0009581) 4.987PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
detection of abiotic stimulus (GO:0009582) 4.967PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
detection of light stimulus (GO:0009583) 5.677PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
detection of stimulus (GO:0051606) 3.227PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
response to external stimulus (GO:0009605) 2.557PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
single-organism cellular process (GO:0044763) 0.657GPR179, PDE6B, TRPM1, SLC24A1, GRM6, RHO, GNAT1
cellular response to radiation (GO:0071478) 4.816PDE6B, TRPM1, SAG, RHO, GRK1, GNAT1
cellular response to stimulus (GO:0051716) 1.976PDE6B, TRPM1, SAG, RHO, GRK1, GNAT1
cellular response to abiotic stimulus (GO:0071214) 4.156PDE6B, TRPM1, SAG, RHO, GRK1, GNAT1
cellular response to light stimulus (GO:0071482) 5.226PDE6B, TRPM1, SAG, RHO, GRK1, GNAT1
developmental process (GO:0032502) 1.365TRPM1, RHO, GRM6, GNAT1, PDE6B
detection of visible light (GO:0009584) 6.235CACNA1F, RHO, GRM6, GNAT1, PDE6B
regulation of rhodopsin mediated signaling pathway (GO:0022400) 6.475RHO, SAG, GRK1, PDE6B, GNAT1
regulation of response to external stimulus (GO:0032101) 3.065RHO, SAG, GRK1, PDE6B, GNAT1
rhodopsin mediated signaling pathway (GO:0016056) 7.245RHO, SAG, GRK1, GNAT1, PDE6B
anatomical structure development (GO:0048856) 1.585TRPM1, RHO, GRM6, GNAT1, PDE6B
phototransduction (GO:0007602) 5.995RHO, SAG, GRK1, GNAT1, PDE6B
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) 4.975RHO, SAG, GRK1, GNAT1, PDE6B
cell surface receptor signaling pathway (GO:0007166) 2.095TRPM1, NYX, SAG, GRM6, PDE6B
regulation of biological quality (GO:0065008) 1.685TRPM1, GRK1, SLC24A1, CACNA1F, PDE6B
homeostatic process (GO:0042592) 2.614TRPM1, CACNA1F, SLC24A1, PDE6B
retina development in camera-type eye (GO:0060041) 5.514RHO, GRM6, PDE6B, GNAT1
localization (GO:0051179) 1.44TRPM1, GPR179, SLC24A1, CACNA1F
detection of light stimulus involved in sensory perception (GO:0050962) 6.843CACNA1F, GRM6, GNAT1
cellular cation homeostasis (GO:0030003) 3.63TRPM1, SLC24A1, PDE6B
negative regulation of molecular function (GO:0044092) 2.743NYX, SAG, GNAT1
ion homeostasis (GO:0050801) 3.423TRPM1, SLC24A1, PDE6B
detection of stimulus involved in sensory perception (GO:0050906) 3.463CACNA1F, GRM6, GNAT1
calcium ion homeostasis (GO:0055074) 3.973TRPM1, SLC24A1, PDE6B
inorganic ion homeostasis (GO:0098771) 3.433TRPM1, SLC24A1, PDE6B
detection of light stimulus involved in visual perception (GO:0050908) 6.843CACNA1F, GRM6, GNAT1
negative regulation of catalytic activity (GO:0043086) 3.03NYX, SAG, GNAT1
cellular calcium ion homeostasis (GO:0006874) 4.013TRPM1, SLC24A1, PDE6B
divalent inorganic cation homeostasis (GO:0072507) 3.93TRPM1, SLC24A1, PDE6B
cellular divalent inorganic cation homeostasis (GO:0072503) 3.963TRPM1, SLC24A1, PDE6B
organic substance metabolic process (GO:0071704) 0.633GRK1, RHO, PDE6B
inorganic cation transmembrane transport (GO:0098662) 3.553TRPM1, CACNA1F, SLC24A1
inorganic ion transmembrane transport (GO:0098660) 3.383TRPM1, CACNA1F, SLC24A1
regulation of molecular function (GO:0065009) 1.783NYX, SAG, GNAT1
cellular homeostasis (GO:0019725) 3.233TRPM1, SLC24A1, PDE6B
regulation of catalytic activity (GO:0050790) 1.973NYX, SAG, GNAT1
cellular metal ion homeostasis (GO:0006875) 3.753TRPM1, SLC24A1, PDE6B
cation transport (GO:0006812) 3.113TRPM1, CACNA1F, SLC24A1
ion transport (GO:0006811) 2.663TRPM1, CACNA1F, SLC24A1
transport (GO:0006810) 1.513TRPM1, CACNA1F, SLC24A1
calcium ion transport (GO:0006816) 4.333TRPM1, CACNA1F, SLC24A1
phototransduction, visible light (GO:0007603) 7.533RHO, PDE6B, GNAT1
ion transmembrane transport (GO:0034220) 3.083TRPM1, CACNA1F, SLC24A1
metal ion transport (GO:0030001) 3.363TRPM1, CACNA1F, SLC24A1
cellular ion homeostasis (GO:0006873) 3.573TRPM1, SLC24A1, PDE6B
metabolic process (GO:0008152) 0.583GRK1, RHO, PDE6B
metal ion homeostasis (GO:0055065) 3.613TRPM1, SLC24A1, PDE6B
cation homeostasis (GO:0055080) 3.463TRPM1, SLC24A1, PDE6B
divalent metal ion transport (GO:0070838) 4.153TRPM1, CACNA1F, SLC24A1
cellular chemical homeostasis (GO:0055082) 3.43TRPM1, SLC24A1, PDE6B
establishment of localization (GO:0051234) 1.483TRPM1, CACNA1F, SLC24A1
transmembrane transport (GO:0055085) 2.723TRPM1, CACNA1F, SLC24A1
primary metabolic process (GO:0044238) 0.693GRK1, RHO, PDE6B
divalent inorganic cation transport (GO:0072511) 4.133TRPM1, CACNA1F, SLC24A1
calcium ion transmembrane transport (GO:0070588) 4.673TRPM1, CACNA1F, SLC24A1
cellular metabolic process (GO:0044237) 0.693GRK1, RHO, PDE6B
chemical homeostasis (GO:0048878) 2.973TRPM1, SLC24A1, PDE6B
phosphate-containing compound metabolic process (GO:0006796) 2.163GRK1, RHO, PDE6B
phosphorus metabolic process (GO:0006793) 2.153GRK1, RHO, PDE6B
cation transmembrane transport (GO:0098655) 3.433TRPM1, CACNA1F, SLC24A1
regulation of membrane potential (GO:0042391) 3.892CACNA1F, GRK1
regulation of transport (GO:0051049) 2.242CACNA1F, GRM6
cell development (GO:0048468) 3.282TRPM1, GNAT1
signaling (GO:0023052) 3.252CACNA1F, GRM6
cellular component organization or biogenesis (GO:0071840) 1.222TRPM1, GPR179
eye photoreceptor cell development (GO:0042462) 6.232TRPM1, GNAT1
cellular protein metabolic process (GO:0044267) 1.632GRK1, RHO
single-organism metabolic process (GO:0044710) 1.632RHO, PDE6B
photoreceptor cell development (GO:0042461) 6.172TRPM1, GNAT1
cellular macromolecule metabolic process (GO:0044260) 0.932GRK1, RHO
cellular developmental process (GO:0048869) 1.822TRPM1, GNAT1
G-protein coupled glutamate receptor signaling pathway (GO:0007216) 7.092TRPM1, GRM6
cellular component organization (GO:0016043) 1.242TRPM1, GPR179
glutamate receptor signaling pathway (GO:0007215) 5.992TRPM1, GRM6
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.782GRM6, GNAT1
regulation of ion transport (GO:0043269) 3.42CACNA1F, GRM6
phosphorylation (GO:0016310) 2.632GRK1, RHO
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62GRM6, GNAT1
neuron development (GO:0048666) 4.82TRPM1, GNAT1
protein phosphorylation (GO:0006468) 2.892GRK1, RHO
cellular protein modification process (GO:0006464) 1.792GRK1, RHO
single-organism developmental process (GO:0044767) 1.492TRPM1, GNAT1
macromolecule modification (GO:0043412) 1.732GRK1, RHO
protein modification process (GO:0036211) 1.792GRK1, RHO
regulation of localization (GO:0032879) 1.942CACNA1F, GRM6
response to light intensity (GO:0009642) 7.532SLC24A1, GNAT1
single-organism localization (GO:1902578) 2.092TRPM1, GPR179
single organism signaling (GO:0044700) 3.252CACNA1F, GRM6
single-multicellular organism process (GO:0044707) 1.782CACNA1F, RHO
protein metabolic process (GO:0019538) 1.452GRK1, RHO
macromolecule metabolic process (GO:0043170) 0.832GRK1, RHO
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412TRPM1, PDE6B

NET-GE enrichment

Term New enriched termICP valueGenes
detection of light stimulus involved in sensory perception (GO:0050962) -6.840.001CACNA1F, GRM6, GNAT1
cellular response to light stimulus (GO:0071482) -5.220.0PDE6B, TRPM1, SAG, SLC24A1, RHO, GRK1, GNAT1
regulation of rhodopsin mediated signaling pathway (GO:0022400) -6.470.0RHO, SAG, GRK1, PDE6B, GNAT1
regulation of response to external stimulus (GO:0032101) -3.060.006RHO, SAG, GRK1, PDE6B, GNAT1
response to radiation (GO:0009314) -3.690.0GRK1, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) -4.970.001RHO, SAG, GRK1, GNAT1, PDE6B
multicellular organismal process (GO:0032501) -1.450.0GPR179, SAG, PDE6B, TRPM1, CACNA1F, SLC24A1, NYX, RHO, GRK1, GNAT1
response to light stimulus (GO:0009416) -4.080.0GRK1, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
retina development in camera-type eye (GO:0060041) -5.510.0CACNA1F, RHO, GRM6, PDE6B, GNAT1
cell surface receptor signaling pathway (GO:0007166) -2.090.004GPR179, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
detection of light stimulus involved in visual perception (GO:0050908) -6.840.001CACNA1F, GRM6, GNAT1
eye photoreceptor cell development (GO:0042462) -6.230.014TRPM1, RHO, GNAT1
tissue development (GO:0009888) NEW3.270.009CACNA1F, RHO, GRM6, PDE6B, GNAT1
cellular response to radiation (GO:0071478) -4.810.0PDE6B, TRPM1, SAG, SLC24A1, RHO, GRK1, GNAT1
G-protein coupled glutamate receptor signaling pathway (GO:0007216) -7.090.042TRPM1, GRM6
cellular response to abiotic stimulus (GO:0071214) -4.150.0PDE6B, TRPM1, SAG, SLC24A1, RHO, GRK1, GNAT1
G-protein coupled receptor signaling pathway (GO:0007186) -2.640.0GPR179, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
detection of external stimulus (GO:0009581) -4.980.0PDE6B, CACNA1F, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
detection of abiotic stimulus (GO:0009582) -4.960.0PDE6B, CACNA1F, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
detection of light stimulus (GO:0009583) -5.670.0GRK1, PDE6B, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
detection of visible light (GO:0009584) -6.230.0GRK1, PDE6B, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
neurological system process (GO:0050877) -2.640.0GPR179, SAG, PDE6B, TRPM1, CACNA1F, SLC24A1, NYX, RHO, GRK1, GNAT1
visual perception (GO:0007601) -4.410.0GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, RHO, CACNA1F, GNAT1
sensory perception (GO:0007600) -2.930.0GPR179, RHO, PDE6B, TRPM1, GRK1, SLC24A1, NYX, CACNA1F, SAG, GNAT1
sensory perception of light stimulus (GO:0050953) -4.40.0GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, RHO, CACNA1F, GNAT1
phototransduction (GO:0007602) -5.990.0PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
photoreceptor cell development (GO:0042461) -6.170.017TRPM1, RHO, GNAT1
phototransduction, visible light (GO:0007603) -7.530.0PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
response to light intensity (GO:0009642) -7.530.005SLC24A1, GNAT1
system process (GO:0003008) -2.30.0GPR179, RHO, PDE6B, TRPM1, GRK1, SLC24A1, NYX, CACNA1F, SAG, GNAT1
response to abiotic stimulus (GO:0009628) -2.80.005GRK1, PDE6B, TRPM1, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
detection of stimulus (GO:0051606) -3.220.0PDE6B, CACNA1F, SAG, SLC24A1, GRM6, RHO, GRK1, GNAT1
single-multicellular organism process (GO:0044707) -1.780.0GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, RHO, CACNA1F, GNAT1
response to external stimulus (GO:0009605) -2.550.0GRK1, PDE6B, SAG, SLC24A1, GRM6, RHO, CACNA1F, GNAT1
rhodopsin mediated signaling pathway (GO:0016056) -7.240.0PDE6B, SAG, SLC24A1, RHO, GRK1, GNAT1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1112GPR179, GRK1, PDE6B, TRPM1, SAG, SLC24A1, NYX, LRIT3, GRM6, RHO, CACNA1F, GNAT1
membrane part (GO:0044425) 0.9510GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, LRIT3, GRM6, RHO, GRK1, GNAT1
membrane (GO:0016020) 0.6810GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, LRIT3, GRM6, RHO, GRK1, GNAT1
integral component of membrane (GO:0016021) 1.148GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, LRIT3, RHO, GRM6
plasma membrane part (GO:0044459) 1.958PDE6B, TRPM1, CACNA1F, SLC24A1, GRM6, RHO, GRK1, GNAT1
intrinsic component of membrane (GO:0031224) 1.138GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, LRIT3, RHO, GRM6
plasma membrane (GO:0005886) 1.398GPR179, PDE6B, TRPM1, CACNA1F, SLC24A1, GRM6, RHO, GNAT1
intracellular part (GO:0044424) 0.287SAG, NYX, LRIT3, GRM6, RHO, GRK1, GNAT1
neuron part (GO:0097458) 2.647GPR179, PDE6B, GRK1, GRM6, RHO, SAG, GNAT1
organelle (GO:0043226) 0.46PDE6B, SAG, LRIT3, GRM6, RHO, GNAT1
organelle part (GO:0044422) 0.796PDE6B, GRK1, LRIT3, GRM6, RHO, GNAT1
plasma membrane region (GO:0098590) 2.975RHO, GRM6, GRK1, GNAT1, PDE6B
organelle membrane (GO:0031090) 1.975RHO, GRM6, GRK1, PDE6B, GNAT1
bounding membrane of organelle (GO:0098588) 2.395RHO, GRM6, GRK1, PDE6B, GNAT1
cell projection part (GO:0044463) 2.975RHO, GPR179, GRK1, GNAT1, PDE6B
cytoplasmic part (GO:0044444) 0.825RHO, SAG, LRIT3, GRM6, GNAT1
cell projection (GO:0042995) 2.475RHO, GRM6, SAG, PDE6B, GNAT1
photoreceptor disc membrane (GO:0097381) 6.914RHO, GRK1, GNAT1, PDE6B
primary cilium (GO:0072372) 4.644RHO, SAG, PDE6B, GNAT1
ciliary membrane (GO:0060170) 5.434RHO, GRK1, GNAT1, PDE6B
ciliary part (GO:0044441) 4.054RHO, GRK1, PDE6B, GNAT1
cell projection membrane (GO:0031253) 4.114RHO, GRK1, GNAT1, PDE6B
nonmotile primary cilium (GO:0031513) 5.144RHO, SAG, GNAT1, PDE6B
integral component of plasma membrane (GO:0005887) 2.574TRPM1, SLC24A1, RHO, GRM6
cilium (GO:0005929) 3.894RHO, SAG, PDE6B, GNAT1
intrinsic component of plasma membrane (GO:0031226) 2.534TRPM1, SLC24A1, RHO, GRM6
photoreceptor outer segment (GO:0001750) 5.784RHO, SAG, GNAT1, PDE6B
cytoplasm (GO:0005737) 1.013NYX, GRK1, GNAT1
intracellular membrane-bounded organelle (GO:0043231) 0.63LRIT3, RHO, GRM6
endoplasmic reticulum membrane (GO:0005789) 2.953LRIT3, RHO, GRM6
intracellular organelle part (GO:0044446) 0.813LRIT3, RHO, GRM6
endoplasmic reticulum part (GO:0044432) 2.733LRIT3, RHO, GRM6
intracellular organelle (GO:0043229) 0.513LRIT3, RHO, GRM6
photoreceptor inner segment (GO:0001917) 6.253SAG, RHO, GNAT1
membrane-bounded organelle (GO:0043227) 0.473LRIT3, RHO, GRM6
protein complex (GO:0043234) 1.512CACNA1F, GNAT1
Golgi apparatus (GO:0005794) 2.72RHO, GRM6
macromolecular complex (GO:0032991) 1.352CACNA1F, GNAT1
endoplasmic reticulum (GO:0005783) 2.562LRIT3, GRM6
photoreceptor outer segment membrane (GO:0042622) 7.092RHO, GNAT1
cell tip (GO:0051286) 8.012TRPM1, GRM6
cytosol (GO:0005829) 1.682SAG, GNAT1
site of polarized growth (GO:0030427) 4.852TRPM1, GRM6
intracellular (GO:0005622) 2.372TRPM1, NYX
plasma membrane protein complex (GO:0098797) 3.552CACNA1F, GNAT1
membrane protein complex (GO:0098796) 2.842CACNA1F, GNAT1
Golgi apparatus part (GO:0044431) 3.02RHO, GRM6
new growing cell tip (GO:0035841) 9.112TRPM1, GRM6
growing cell tip (GO:0035838) 8.72TRPM1, GRM6
Golgi membrane (GO:0000139) 3.282RHO, GRM6

NET-GE enrichment

Term New enriched termICP valueGenes
photoreceptor disc membrane (GO:0097381) -6.910.0RHO, GRK1, GNAT1, PDE6B
plasma membrane region (GO:0098590) -2.970.007RHO, GRK1, PDE6B, GNAT1
membrane region (GO:0098589) NEW3.950.006PDE6B, GRK1, LRIT3, GRM6, RHO, GNAT1
photoreceptor outer segment membrane (GO:0042622) -7.090.003RHO, GNAT1
cell pole (GO:0060187) NEW9.110.006TRPM1, GRM6
cell tip (GO:0051286) -8.010.001TRPM1, GRM6
ciliary membrane (GO:0060170) -5.430.0RHO, GRK1, PDE6B, GNAT1
new growing cell tip (GO:0035841) -9.110.0TRPM1, GRM6
cell projection membrane (GO:0031253) -4.110.001RHO, GRK1, PDE6B, GNAT1
nonmotile primary cilium (GO:0031513) -5.140.0RHO, SAG, CACNA1F, GNAT1
neuron part (GO:0097458) -2.640.0PDE6B, CACNA1F, SAG, GRM6, RHO, GRK1, GNAT1
primary cilium (GO:0072372) -4.640.004CACNA1F, SAG, RHO, GNAT1
photoreceptor inner segment (GO:0001917) -6.250.0SAG, RHO, GNAT1
ciliary part (GO:0044441) -4.050.001RHO, GRK1, PDE6B, GNAT1
cilium (GO:0005929) -3.890.001CACNA1F, RHO, SAG, PDE6B, GNAT1
cell projection (GO:0042995) -2.470.028CACNA1F, RHO, SAG, GRM6, GNAT1
plasma membrane part (GO:0044459) -1.950.001PDE6B, TRPM1, CACNA1F, SLC24A1, GRM6, RHO, GRK1, GNAT1
photoreceptor outer segment (GO:0001750) -5.780.0CACNA1F, SAG, RHO, GNAT1
growing cell tip (GO:0035838) -8.70.0TRPM1, GRM6