Disease table of PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY OMIM ID: PS312170

Gene-disease associations table

Gene	Associated with PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
PDHX	ClinVar, OMIM	HGNC link	11p13	1	PS312170
PDHA1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp22.12	1	PS312170
LIAS	ClinVar, OMIM, HUMSAVAR	HGNC link	4p14	1	PS312170
PDP1	ClinVar, OMIM	HGNC link	8q22.1	1	PS312170
DLAT	ClinVar, OMIM	HGNC link	11q23.1	1	PS312170
PDHB	ClinVar, OMIM, HUMSAVAR	HGNC link	3p14.3	1	PS312170

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	PDHX, DLAT

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
PDHX	YES	1	PAX6	0
PDHA1	YES	3	SP1, JUN, FOS	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PDHX	PDHA1	Yes	8	DLD, DLAT, OGDH, HDAC6, STAT5B, STAT5A, PDHB, PDK1
PDHX	DLAT	Yes	11	DLD, NF2, PDHA1, OGDH, HDAC6, STAT5A, PDK2, STAT5B, CS, PDHB, PDK1
PDHX	PDHB	Yes	10	DLD, CDKN1A, PDHA1, OGDH, HDAC6, STAT5A, PDK2, STAT5B, PDK1, DLAT
PDHA1	DLAT	Yes	14	DLD, ADRB2, STAT5A, PDHB, OGDH, HDAC6, STAT5B, SIRT7, PPT1, PDHX, SDHB, NTRK1, ATP1B1, PDK1
PDHA1	PDHB	Yes	14	DLD, DLAT, STAT5A, ADRB2, PTBP1, HDAC6, OGDH, HUWE1, STAT5B, PDHX, PPT1, CUL3, NTRK1, PDK1
DLAT	PDHB	Yes	14	DLD, ADRB2, PDHA2, PDHA1, OGDH, HDAC6, STAT5A, PDHX, PPT1, STAT5B, PDK2, NTRK1, PDK3, PDK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
PDHX	PDHA1	Yes	binding	9	DLD, ACLY, PITRM1, PDK2, PDHB, BCKDHB, PDK3, PDK4, PDK1
PDHX	PDP1	No	-	1	PDHA1
PDHX	DLAT	No	-	19	DLD, ACLY, BCKDHB, PDHA2, TXNRD2, GSR, OGDH, PDHA1, BCKDHA, PDK2, SUCLA2, OGDHL, PDHB, SUCLG2, TXNRD3, DHTKD1, TXNRD1, PITRM1, PDK1
PDHX	PDHB	Yes	binding	13	DLD, TXNRD2, PDHA2, TXNRD3, GSR, PITRM1, PDHA1, TXNRD1, PDK2, BCKDHA, PDK3, PDK4, PDK1
PDHA1	PDP1	Yes	binding	0
PDHA1	DLAT	Yes	binding	7	DLD, ACLY, PITRM1, PDK2, PDHB, BCKDHB, PDK1
PDHA1	PDHB	Yes	binding	10	DLD, DBT, DLAT, PITRM1, PDK2, DLST, PDHX, PDK3, PDK4, PDK1
PDP1	DLAT	No	-	1	PDHA1
PDP1	PDHB	No	-	1	PDHA1
DLAT	PDHB	Yes	binding	11	DLD, TXNRD2, PDHA2, GSR, PITRM1, PDHA1, TXNRD1, PDK2, BCKDHA, TXNRD3, PDK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PDHX	PDHA1	Yes	3	OGDH, DLAT, PDHB
PDHX	DLAT	Yes	2	OGDH, PDHA1
PDHX	PDHB	Yes	2	OGDH, PDHA1
PDHA1	DLAT	Yes	2	OGDH, PDHX
PDHA1	PDHB	Yes	2	OGDH, PDHX
DLAT	PDHB	No	3	OGDH, PDHA1, PDHX

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
PDHA1	PDHB	Yes	2	PDHA1, PDHB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	5	PDHB, DLAT, PDHA1, LIAS, PDHX
Pyruvate metabolism	hsa00620	7.45	3	DLAT, PDHA1, PDHB
Carbon metabolism	hsa01200	6.03	3	DLAT, PDHA1, PDHB
Glycolysis / Gluconeogenesis	hsa00010	6.64	3	DLAT, PDHA1, PDHB
Citrate cycle (TCA cycle)	hsa00020	7.86	3	DLAT, PDHA1, PDHB
HIF-1 signaling pathway	hsa04066	5.9	2	PDHA1, PDHB
Central carbon metabolism in cancer	hsa05230	6.7	2	PDHA1, PDHB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Global and overview maps	NEW	2.47	0.003	DLAT, LIAS, PDHA1, PDHB, PDHX
Metabolism	NEW	2.06	0.013	DLAT, LIAS, PDHA1, PDHB, PDHX
Pyruvate metabolism (hsa00620)	-	7.45	0.0	DLAT, PDHA1, PDHB
Carbohydrate metabolism	NEW	4.36	0.018	DLAT, PDHA1, PDHB
Carbon metabolism (hsa01200)	-	6.03	0.001	DLAT, PDHA1, PDHB
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.015	PDHA1, PDHB
HIF-1 signaling pathway (hsa04066)	-	5.9	0.046	PDHA1, PDHB
Glycolysis / Gluconeogenesis (hsa00010)	-	6.64	0.001	DLAT, PDHA1, PDHB
Metabolic pathways (hsa01100)	-	2.49	0.044	DLAT, LIAS, PDHA1, PDHB, PDHX
Citrate cycle (TCA cycle) (hsa00020)	-	7.86	0.0	DLAT, PDHA1, PDHB

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Regulation of pyruvate dehydrogenase (PDH) complex	R-HSA-204174	9.18	5	DLAT, PDP1, PDHA1, PDHB, PDHX
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	5	DLAT, PDP1, PDHA1, PDHB, PDHX
Pyruvate metabolism	R-HSA-70268	8.52	5	DLAT, PDP1, PDHA1, PDHB, PDHX
Pyruvate metabolism and Citric Acid (TCA) cycle	R-HSA-71406	7.56	5	DLAT, PDP1, PDHA1, PDHB, PDHX
Metabolism	R-HSA-1430728	2.34	5	DLAT, PDP1, PDHA1, PDHB, PDHX
Signal Transduction	R-HSA-162582	1.78	4	DLAT, PDHA1, PDHB, PDHX
Signaling by Retinoic Acid	R-HSA-5362517	7.62	4	DLAT, PDHA1, PDHB, PDHX

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406)	-	7.56	0.0	PDHB, PDP1, PDHA1, DLAT, PDHX
Regulation of pyruvate dehydrogenase (PDH) complex (R-HSA-204174)	-	9.18	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517)	-	5.71	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
Pyruvate metabolism (R-HSA-70268)	-	8.52	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
Metabolism (R-HSA-1430728)	-	2.34	0.002	DLAT, PDP1, PDHA1, PDHB, PDHX
Signaling by Retinoic Acid (R-HSA-5362517)	-	7.62	0.0	DLAT, PDHA1, PDHB, PDHX

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
catalytic activity (GO:0003824)	1.05	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
binding (GO:0005488)	0.18	5	DLAT, PDP1, LIAS, PDHB, PDHX
pyruvate dehydrogenase activity (GO:0004738)	7.95	4	DLAT, PDHA1, PDHB, PDHX
pyruvate dehydrogenase (NAD+) activity (GO:0034604)	7.95	4	DLAT, PDHA1, PDHB, PDHX
pyruvate dehydrogenase [NAD(P)+] activity (GO:0034603)	7.95	4	DLAT, PDHA1, PDHB, PDHX
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)	6.13	4	DLAT, PDHA1, PDHB, PDHX
oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)	5.87	4	DLAT, PDHA1, PDHB, PDHX
protein binding (GO:0005515)	0.46	4	DLAT, PDP1, PDHB, PDHX
oxidoreductase activity (GO:0016491)	3.12	4	DLAT, PDHA1, PDHB, PDHX
transferase activity (GO:0016740)	1.95	3	DLAT, LIAS, PDHX
cation binding (GO:0043169)	1.4	2	PDP1, LIAS
pyruvate dehydrogenase (acetyl-transferring) activity (GO:0004739)	8.64	2	PDHA1, PDHB
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624)	7.44	2	PDHA1, PDHB
ion binding (GO:0043167)	1.36	2	PDP1, LIAS
transferase activity, transferring acyl groups (GO:0016746)	4.2	2	DLAT, PDHX
metal ion binding (GO:0046872)	1.41	2	PDP1, LIAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
pyruvate dehydrogenase activity (GO:0004738)	-	7.95	0.0	PDHA1, PDHB
pyruvate dehydrogenase (acetyl-transferring) activity (GO:0004739)	-	8.64	0.0	PDHA1, PDHB
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624)	-	7.44	0.0	PDHA1, PDHB
oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)	-	5.87	0.026	PDHA1, PDHB
transferase activity, transferring acyl groups (GO:0016746)	-	4.2	0.043	DLAT, PDHB, PDHX

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
organic substance metabolic process (GO:0071704)	0.63	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
cellular process (GO:0009987)	0.26	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
cellular metabolic process (GO:0044237)	0.69	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
metabolic process (GO:0008152)	0.58	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
primary metabolic process (GO:0044238)	0.69	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
regulation of primary metabolic process (GO:0080090)	1.08	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of metabolic process (GO:0019222)	1.02	5	DLAT, PDP1, PDHA1, PDHB, PDHX
coenzyme metabolic process (GO:0006732)	4.14	5	DLAT, LIAS, PDHA1, PDHB, PDHX
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of cellular metabolic process (GO:0031323)	1.07	5	DLAT, PDP1, PDHA1, PDHB, PDHX
carboxylic acid metabolic process (GO:0019752)	3.12	5	DLAT, LIAS, PDHA1, PDHB, PDHX
regulation of cellular ketone metabolic process (GO:0010565)	4.67	5	DLAT, PDP1, PDHA1, PDHB, PDHX
cellular biosynthetic process (GO:0044249)	1.37	5	DLAT, LIAS, PDHA1, PDHB, PDHX
coenzyme biosynthetic process (GO:0009108)	4.89	5	DLAT, LIAS, PDHA1, PDHB, PDHX
small molecule metabolic process (GO:0044281)	2.38	5	DLAT, LIAS, PDHA1, PDHB, PDHX
regulation of biological process (GO:0050789)	0.45	5	DLAT, PDP1, PDHA1, PDHB, PDHX
single-organism process (GO:0044699)	0.48	5	DLAT, LIAS, PDHA1, PDHB, PDHX
regulation of sulfur metabolic process (GO:0042762)	6.73	5	DLAT, PDP1, PDHA1, PDHB, PDHX
organic substance biosynthetic process (GO:1901576)	1.34	5	DLAT, LIAS, PDHA1, PDHB, PDHX
single-organism metabolic process (GO:0044710)	1.63	5	DLAT, LIAS, PDHA1, PDHB, PDHX
single-organism biosynthetic process (GO:0044711)	2.8	5	PDHB, DLAT, PDHA1, LIAS, PDHX
cofactor biosynthetic process (GO:0051188)	4.62	5	PDHB, DLAT, PDHA1, LIAS, PDHX
biological regulation (GO:0065007)	0.39	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of fatty acid metabolic process (GO:0019217)	5.25	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of lipid metabolic process (GO:0019216)	4.08	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of biosynthetic process (GO:0009889)	1.37	5	DLAT, PDP1, PDHA1, PDHB, PDHX
monocarboxylic acid metabolic process (GO:0032787)	3.57	5	DLAT, LIAS, PDHA1, PDHB, PDHX
biosynthetic process (GO:0009058)	1.32	5	DLAT, LIAS, PDHA1, PDHB, PDHX
cofactor metabolic process (GO:0051186)	3.91	5	DLAT, LIAS, PDHA1, PDHB, PDHX
single-organism cellular process (GO:0044763)	0.65	5	DLAT, LIAS, PDHA1, PDHB, PDHX
regulation of acyl-CoA biosynthetic process (GO:0050812)	7.16	5	DLAT, PDP1, PDHA1, PDHB, PDHX
oxoacid metabolic process (GO:0043436)	3.12	5	DLAT, LIAS, PDHA1, PDHB, PDHX
glyoxylate metabolic process (GO:0046487)	6.4	5	PDHB, DLAT, PDHA1, LIAS, PDHX
regulation of cellular process (GO:0050794)	0.5	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of coenzyme metabolic process (GO:0051196)	5.8	5	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of cofactor metabolic process (GO:0051193)	5.8	5	PDHB, PDP1, PDHA1, DLAT, PDHX
organic acid metabolic process (GO:0006082)	3.01	5	PDHB, DLAT, PDHA1, LIAS, PDHX
regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	7.24	5	PDHB, PDP1, PDHA1, DLAT, PDHX
acetyl-CoA metabolic process (GO:0006084)	6.47	4	DLAT, PDHA1, PDHB, PDHX
acetyl-CoA biosynthetic process (GO:0006085)	7.24	4	DLAT, PDHA1, PDHB, PDHX
thioester metabolic process (GO:0035383)	5.31	4	DLAT, PDHA1, PDHB, PDHX
acyl-CoA metabolic process (GO:0006637)	5.31	4	DLAT, PDHA1, PDHB, PDHX
thioester biosynthetic process (GO:0035384)	5.74	4	DLAT, PDHA1, PDHB, PDHX
sulfur compound biosynthetic process (GO:0044272)	4.5	4	DLAT, PDHA1, PDHB, PDHX
acetyl-CoA biosynthetic process from pyruvate (GO:0006086)	7.65	4	DLAT, PDHA1, PDHB, PDHX
phosphate-containing compound metabolic process (GO:0006796)	2.16	4	PDP1, PDHA1, PDHB, PDHX
sulfur compound metabolic process (GO:0006790)	3.87	4	DLAT, PDHA1, PDHB, PDHX
acyl-CoA biosynthetic process (GO:0071616)	5.74	4	DLAT, PDHA1, PDHB, PDHX
phosphorus metabolic process (GO:0006793)	2.15	4	PDP1, PDHA1, PDHB, PDHX
pyruvate metabolic process (GO:0006090)	5.51	4	DLAT, PDHA1, PDHB, PDHX
oxidoreduction coenzyme metabolic process (GO:0006733)	5.03	3	PDHA1, PDHB, PDHX
mitochondrial acetyl-CoA biosynthetic process from pyruvate (GO:0061732)	7.94	3	PDHA1, PDHB, PDHX
tricarboxylic acid cycle (GO:0006099)	6.33	3	DLAT, PDHA1, PDHB
nitrogen compound metabolic process (GO:0006807)	1.13	3	PDHA1, PDHB, PDHX
nicotinamide nucleotide metabolic process (GO:0046496)	5.14	3	PDHA1, PDHB, PDHX
pyridine-containing compound metabolic process (GO:0072524)	5.07	3	PDHA1, PDHB, PDHX
organic cyclic compound metabolic process (GO:1901360)	1.26	3	PDHA1, PDHB, PDHX
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	PDHA1, PDHB, PDHX
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	PDHA1, PDHB, PDHX
hexose metabolic process (GO:0019318)	4.64	3	DLAT, PDHA1, PDHB
nucleotide metabolic process (GO:0009117)	3.73	3	PDHA1, PDHB, PDHX
single-organism carbohydrate metabolic process (GO:0044723)	3.42	3	DLAT, PDHA1, PDHB
carbohydrate metabolic process (GO:0005975)	3.26	3	DLAT, PDHA1, PDHB
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	3	PDHA1, PDHB, PDHX
heterocycle metabolic process (GO:0046483)	1.31	3	PDHA1, PDHB, PDHX
organonitrogen compound metabolic process (GO:1901564)	2.32	3	PDHA1, PDHB, PDHX
monosaccharide metabolic process (GO:0005996)	4.57	3	DLAT, PDHA1, PDHB
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	PDHA1, PDHB, PDHX
organophosphate metabolic process (GO:0019637)	3.04	3	PDHA1, PDHB, PDHX
glucose metabolic process (GO:0006006)	4.94	3	DLAT, PDHA1, PDHB
nucleoside phosphate metabolic process (GO:0006753)	3.71	3	PDHA1, PDHB, PDHX
pyridine nucleotide metabolic process (GO:0019362)	5.14	3	PDHA1, PDHB, PDHX
cellular protein metabolic process (GO:0044267)	1.63	2	PDP1, LIAS
cellular macromolecule metabolic process (GO:0044260)	0.93	2	PDP1, LIAS
protein metabolic process (GO:0019538)	1.45	2	PDP1, LIAS
cellular protein modification process (GO:0006464)	1.79	2	PDP1, LIAS
macromolecule metabolic process (GO:0043170)	0.83	2	PDP1, LIAS
macromolecule modification (GO:0043412)	1.73	2	PDP1, LIAS
protein modification process (GO:0036211)	1.79	2	PDP1, LIAS
oxidation-reduction process (GO:0055114)	2.91	2	PDHA1, PDHB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
acyl-CoA metabolic process (GO:0006637)	-	5.31	0.018	PDHA1, PDHB
coenzyme metabolic process (GO:0006732)	-	4.14	0.003	PDHA1, LIAS, PDHB
carboxylic acid metabolic process (GO:0019752)	-	3.12	0.0	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
regulation of cellular ketone metabolic process (GO:0010565)	-	4.67	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
tricarboxylic acid cycle (GO:0006099)	-	6.33	0.0	DLAT, PDHA1, PDHB
coenzyme biosynthetic process (GO:0009108)	-	4.89	0.0	PDHA1, LIAS, PDHB
small molecule metabolic process (GO:0044281)	-	2.38	0.001	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
pyruvate metabolic process (GO:0006090)	-	5.51	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of sulfur metabolic process (GO:0042762)	-	6.73	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
single-organism metabolic process (GO:0044710)	-	1.63	0.037	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
cofactor metabolic process (GO:0051186)	-	3.91	0.007	PDHA1, LIAS, PDHB
cofactor biosynthetic process (GO:0051188)	-	4.62	0.024	PDHA1, LIAS, PDHB
acetyl-CoA metabolic process (GO:0006084)	-	6.47	0.01	PDHA1, PDHB
thioester metabolic process (GO:0035383)	-	5.31	0.018	PDHA1, PDHB
thioester biosynthetic process (GO:0035384)	-	5.74	0.013	PDHA1, PDHB
regulation of fatty acid metabolic process (GO:0019217)	-	5.25	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of lipid metabolic process (GO:0019216)	-	4.08	0.0	PDHB, PDP1, PDHA1, DLAT, PDHX
hexose metabolic process (GO:0019318)	-	4.64	0.003	DLAT, PDHA1, PDHB, PDHX
monocarboxylic acid metabolic process (GO:0032787)	-	3.57	0.0	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
regulation of phosphorus metabolic process (GO:0051174)	NEW	2.35	0.007	DLAT, PDP1, PDHA1, PDHB, PDHX
regulation of acyl-CoA biosynthetic process (GO:0050812)	-	7.16	0.0	PDHB, PDP1, PDHA1, DLAT, PDHX
oxoacid metabolic process (GO:0043436)	-	3.12	0.003	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
regulation of coenzyme metabolic process (GO:0051196)	-	5.8	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
acetyl-CoA biosynthetic process (GO:0006085)	-	7.24	0.0	PDHA1, PDHB
acetyl-CoA biosynthetic process from pyruvate (GO:0006086)	-	7.65	0.0	PDHA1, PDHB
regulation of cofactor metabolic process (GO:0051193)	-	5.8	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
organic acid metabolic process (GO:0006082)	-	3.01	0.003	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
sulfur compound biosynthetic process (GO:0044272)	-	4.5	0.001	PDHA1, LIAS, PDHB
monosaccharide metabolic process (GO:0005996)	-	4.57	0.004	DLAT, PDHA1, PDHB, PDHX
response to glucose (GO:0009749)	NEW	4.86	0.044	PDHA1, PDHB, PDHX
sulfur compound metabolic process (GO:0006790)	-	3.87	0.011	PDHA1, LIAS, PDHB
acyl-CoA biosynthetic process (GO:0071616)	-	5.74	0.013	PDHA1, PDHB
regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	-	7.24	0.0	PDHB, PDP1, PDHA1, DLAT, PDHX
glucose metabolic process (GO:0006006)	-	4.94	0.001	DLAT, PDHA1, PDHB, PDHX

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
organelle lumen (GO:0043233)	3.05	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
cell part (GO:0044464)	0.11	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
cytoplasmic part (GO:0044444)	0.82	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
mitochondrion (GO:0005739)	2.42	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
intracellular organelle part (GO:0044446)	0.81	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
intracellular organelle lumen (GO:0070013)	3.05	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
intracellular organelle (GO:0043229)	0.51	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
membrane-enclosed lumen (GO:0031974)	3.05	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
mitochondrial matrix (GO:0005759)	4.03	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
intracellular part (GO:0044424)	0.28	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
membrane-bounded organelle (GO:0043227)	0.47	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
organelle (GO:0043226)	0.4	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
organelle part (GO:0044422)	0.79	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
mitochondrial part (GO:0044429)	2.92	6	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
protein complex (GO:0043234)	1.51	4	DLAT, PDHA1, PDHB, PDHX
pyruvate dehydrogenase complex (GO:0045254)	7.72	4	DLAT, PDHA1, PDHB, PDHX
macromolecular complex (GO:0032991)	1.35	4	DLAT, PDHA1, PDHB, PDHX
catalytic complex (GO:1902494)	2.9	4	DLAT, PDHA1, PDHB, PDHX
oxidoreductase complex (GO:1990204)	5.19	4	DLAT, PDHA1, PDHB, PDHX
myelin sheath (GO:0043209)	4.76	2	DLAT, PDHA1
nucleus (GO:0005634)	1.07	2	PDHA1, PDHB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
pyruvate dehydrogenase complex (GO:0045254)	-	7.72	0.0	DLAT, PDHA1, PDHB
mitochondrial part (GO:0044429)	-	2.92	0.0	PDHB, PDP1, PDHA1, DLAT, PDHX
organelle lumen (GO:0043233)	-	3.05	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
mitochondrion (GO:0005739)	-	2.42	0.0	DLAT, PDHA1, PDP1, PDHX, LIAS, PDHB
oxidoreductase complex (GO:1990204)	-	5.19	0.0	DLAT, PDHA1, PDHB, PDHX
intracellular organelle lumen (GO:0070013)	-	3.05	0.002	DLAT, PDP1, PDHA1, PDHB, PDHX
membrane-enclosed lumen (GO:0031974)	-	3.05	0.004	DLAT, PDP1, PDHA1, PDHB, PDHX
mitochondrial matrix (GO:0005759)	-	4.03	0.0	DLAT, PDP1, PDHA1, PDHB, PDHX
catalytic complex (GO:1902494)	-	2.9	0.036	DLAT, PDHA1, PDHB